association	dataset	threshold value	standardized value
GSE143662_3_v_1_dcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
long qt syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.75005
hydrastinine-2283	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
r8 part of the paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.11468
COPS9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8171
JARID2-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4287	TargetScan Predicted Conserved microRNA Targets	1.0	0.031759
DMS53	DepMap CRISPR Gene Dependency	1.0	23.3188
EZH2-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_12934_KD_DHODH_SRP340404	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.80556
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.882458
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.097763
muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.184128
Copula pyramidis, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02202
CCDC184	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3152
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3EV-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LSM14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95933
thyroid gland	HPA Tissue Protein Expression Profiles	1.0	0.756656
ARMCX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51071
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE87412,GSE92423_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Psoriasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.283
GSE111660_4_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Vermal regions	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55384
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
bladder wall	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.191444
sensory cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.442962
PLOD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53387
cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.673328
MEF2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
X	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02219
hsa-miR-493	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Paramedian lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24121
MEF2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21937
FAM104A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47915
GSE96991,GSE97117_5_v_2_il11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cellular component organization or biogenesis	GO Biological Process Annotations 2015	1.0	null
orbital frontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17489
HCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92884
THEM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63103
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HS939-T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.139072
mantle zone of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2696
LEPROT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51776
Inflammation	CTD Gene-Disease Associations	1.0	1.08868
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.206766
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.42232
hsa-miR-124	TargetScan Predicted Conserved microRNA Targets	1.0	0.103424
TAF1	ENCODE Transcription Factor Targets	1.0	null
Developmental and epileptic encephalopathy 32	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.831
LPIN1_OE_GDS2291_587_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
DBNDD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.31585
hsa-miR-3191	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
medullary collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.535042
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5080-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIEZO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40453
MBOAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36822
GSE138001_2_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ion transport domain	InterPro Predicted Protein Domain Annotations	1.0	null
GSE242199_6_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PHF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56336
hsa-miR-4645-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
ventrolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04999
vestibular labyrinth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.171304
ALOX12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85915
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
E2F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55058
r4 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57679
RBM15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19595
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.58012
IGROV1	DepMap CRISPR Gene Dependency	1.0	2.73487
Ventromedial hypothalamic nucleus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50921
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040588
PARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40971
GSE222758_0_v_4_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180951_6_v_3_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43U-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.930407
RPAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97547
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.764054
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
Calyx	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.186
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
LIN7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.621
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01213
Adrenocortical carcinoma_ACC_TCGA-OR-A5J2-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPL22L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77984
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEFF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5636
BACH1	ENCODE Transcription Factor Targets	1.0	null
autoimmunity	GeneRIF Biological Term Annotations	1.0	null
mRNA_SUZ12_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
substantianigra	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.05085
Intrinsic component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE195559_8_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TP53BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36172
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.834082
testis	HPA Tissue Protein Expression Profiles	1.0	0.756656
GSE210101,GSE210114_8_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LETMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93015
Perturb_16317_KD_POU2F2_SRP336261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.24149
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
molecular layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23086
shell of P-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01951
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RCHACV	CCLE Cell Line Gene Expression Profiles	1.0	3.40797
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
KLF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02344
ZXDB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3922
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.95678
Potassium channel, voltage dependent, Kv1.6	InterPro Predicted Protein Domain Annotations	1.0	null
loperamide-5632	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superficial stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63711
SPI1	ENCODE Transcription Factor Targets	1.0	null
GSE169571_3_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cerebellum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27401
NUDT14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33686
superficial stratum of PO1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.46189
superficial stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09898
bephenium hydroxynaphthoate-4668	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ChIP_SUZ12_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Axon hillock	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.386
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
UNC13B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74371
Leading edge membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.62
r7 part of the dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39179
GSE198165,GSE198166_7_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GZ-05A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34329
juxtaparanode region of axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.38405
GSE138863_2_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
monoatomic cation transmembrane transport	GO Biological Process Annotations 2025	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
DIRAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30832
EEF1E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30046
LPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36642
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-1.95453
frontal pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28041
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.10889
hippocampal pyramidal layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.338914
TANGO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00308
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33048
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.964272
GSE137137_1_v_0_rcor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.707162
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.906
isthmus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1962
Cell body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.69
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18655
MAP2K1_druginhibition_172_GSE39984	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.66915
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41752
ChIP_H3K27me3_20682450_humanESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.442418
RNF103	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03498
FAM53B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98029
PLEC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29124
lateral tuberal nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17661
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72824
voltage-gated potassium channel complex	GO Cellular Component Annotations 2025	1.0	null
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TUBB2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36538
GSE152441,GSE152442_1_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pacemaker cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.226
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.88514
GSE150349_0_v_1_msx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8497
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.849823
KCNA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93312
SUZ12	ENCODE Transcription Factor Targets	1.0	null
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.5223
NFIC_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Axon initial segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.069
hsa-miR-4251	TargetScan Predicted Conserved microRNA Targets	1.0	0.092495
leflunomide-2539	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KIAA2026	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89814
synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.186397
GSE96991,GSE97117_5_v_1_il11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SKLMS1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.65036
NRM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86407
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06751
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07682
OCILY19	DepMap CRISPR Gene Dependency	1.0	3.03311
DACT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15857
MAZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34179
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
GSE210580_3_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157555,GSE157556_0_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2790-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Distal axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.753
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE143662_0_v_1_dcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
voltage-gated potassium channel activity	GO Molecular Function Annotations 2023	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
MAPK1IP1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81758
brain_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.78917
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04046
membrane	GO Cellular Component Annotations 2015	1.0	null
HLX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98542
cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45189
Cortical amygdalar area, posterior part, lateral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07842
detrusor	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.232317
ACP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85563
CTSC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61897
GPR37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40885
r5 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03286
SUZ12-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BLOC1S6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00519
TMEM268	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37874
renal medulla cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.499223
Lobule II	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25758
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
DICER1_Deficiency_GDS3685_518_mouse_Hepatocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5712-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058122
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.25613
SOX9-25088423-EMBRYONIC-GONADS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Semicircular canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.818
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE96777,GSE96778_1_v_0_zbtb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
WT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2081
SUZ12-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
UBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25092
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
main axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.0413
Skeletal Muscle Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.13458
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D5-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1723
KMS28BM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51645
GSE154074_2_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
YIF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98854
ChIP_K27me3_17603471_mouseMEF	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
hsa-miR-10b	TargetScan Predicted Conserved microRNA Targets	1.0	0.078844
ETV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34983
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.83948
MYLK_knockdown_48_GSE14525	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	3.29945
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TFDP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59695
H3K4me1_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
collecting duct cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.451813
APOBEC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28111
perimammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27354
hsa-miR-3192	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
Perturb_1160_KD_CELSR2_SRP149837	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.02137
Electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
Stiff-Person syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
midbrain reticular formation	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.943212
dorsomedial nucleus, terminal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01042
artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.382508
superficial stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52132
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7091-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-12q13_11_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
IGFBP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04802
r7 part of rostral ventromedial reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67552
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34318
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.0407
voltage-gated potassium channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
bed nucleus of stria terminalis, lateral amygdaloid division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10936
Sympathetic ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.045
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16866
HMOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4093
RUNX1	ChEA Transcription Factor Targets	1.0	null
motoneuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.45567
mantle zone of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10026
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06079
neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.286877
Brain Lower Grade Glioma_LGG_TCGA-FN-7833-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.802
TAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49558
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.15231
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HELZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55233
brain	HPA Tissue Gene Expression Profiles	1.0	2.22849
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Node of Ranvier	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.772
renal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.278251
18801183-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
how	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04457
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6022-01A-21R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6459557-pbio.3000201.s012.xlsx-Sheet1-FOXD1_FOXD1	Rummagene Transcription Factor Associations 2026	1.0	null
ATP5F1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88918
EZH2	ChEA Transcription Factor Targets	1.0	null
PLEKHG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57965
CHAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63885
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VH-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
peripheral nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.635167
H3K9me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25985
MEGF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74536
GSE138863_3_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25245
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JD-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.45307
spinalcordupper	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.939766
Venom gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.817
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.07118
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061585
Developmental and epileptic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.076
EFO21	Achilles Cell Line Gene Essentiality Profiles	1.0	1.40629
hsa-miR-330-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
GSE183251_1_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7X1-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PBX1-22567123-OVCAR3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
caffeic acid-3053	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MDA-MB-436	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PTCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91041
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.55951
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.005
SLC2A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9788
NH12	DepMap CRISPR Gene Dependency	1.0	2.12012
GSE223008_4_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Main axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.278
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
YIPF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95901
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
DCUN1D4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71794
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18117
ACBD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71977
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1205	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13505
retinal ganglion cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.30464
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_POU5F1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053433
r7 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18625
hypoalgesia	MPO Gene-Phenotype Associations	1.0	null
Uterus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.24
Perturb_7466_KD_ARIEL_SRP136083	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-18.6383
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.949495
MAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62474
Perturb_16632_Mut_Tardbp_SRP133158	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.71913
HDLM2	CCLE Cell Line Gene CNV Profiles	1.0	1.73093
macromolecular complex subunit organization	GO Biological Process Annotations 2015	1.0	null
GSE185944_5_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF516	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27076
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6089
Sarcoma_SARC_TCGA-SI-A71Q-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
synaptic transmission	GO Biological Process Annotations 2015	1.0	null
SGPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22587
ion channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.45852
ACSM2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81546
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
abnormal lipid homeostasis	MPO Gene-Phenotype Associations	1.0	null
cerebellar cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.78215
GSE153836_14_v_5_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
inflorescence	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.592043
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48735
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A410-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.995
RS411	CCLE Cell Line Gene Expression Profiles	1.0	1.81168
IALM	CCLE Cell Line Gene CNV Profiles	1.0	2.20944
Kidney Chromophobe_KICH_TCGA-KL-8336-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18877
CL-40	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12561
abdomen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.104016
Axon collateral	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.806
ventrolateral periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0174
HEATR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03876
PRRC2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43409
H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04603
thiocolchicoside-2875	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JAZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90463
ventral tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74434
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02919
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LCLC-97TM1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12443
benign mesothelioma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.315003
left atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.342971
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
substantia nigra, pars compacta, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.948328
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2112
mRNA_MEF2C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
ANKRD24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75204
RNF2-27304074-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Type 1 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.127
GSE240645_3_v_2_u90926_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RASL11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86942
KAT6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94019
Perturb_12933_KD_CDK9_SRP340404	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.23546
GSE142684_4_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
ZR751	CCLE Cell Line Gene CNV Profiles	1.0	1.59034
prostate cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085551
GSE193588_3_v_2_pax3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6835-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
potassium channel activity	GO Molecular Function Annotations 2015	1.0	null
Sarcoma_SARC_TCGA-DX-A3UA-01A-12R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
HCC33	CCLE Cell Line Gene CNV Profiles	1.0	1.99854
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE221633_3_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pyramus (VIII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.01006
MTA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48679
Proboscis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.59
IRAK2_knockout_39_GSE10765	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.28263
Brain Lower Grade Glioma_LGG_TCGA-HT-7873-01B-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84727
inner SZ in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0187
immunodeficiency	GWASdb SNP-Phenotype Associations	1.0	0.479232
synapse part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.064458
FHIP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29821
hippocampus (hippocampal formation)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.947997
mantle zone of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14729
FEM1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62015
GSE195559_2_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
postsynaptic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.183631
intercalated cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.261284
hsa-miR-4804-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
precentral gyrus, right, superior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09843
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.48543
RBBP5	ENCODE Transcription Factor Targets	1.0	null
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.5193
PMC12318984-Table1.xlsx-S7-Table_S7_Instrumental_variables_IVs_identified_from_eQTL_dataset_for_druggable_GIKs_used_in_Mendelian_randomization_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
LPCAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81917
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040681
ADHD and autism ASD pathways	WikiPathways Pathways 2024	1.0	null
trans-synaptic protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.868
ACSM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75336
Medium spiny neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.042
ventrolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.90631
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-A4DF-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.892455
ZNF346	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40442
ABRAXAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12141
TMEM126A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91048
hsa-let-7g	TargetScan Predicted Conserved microRNA Targets	1.0	0.003282
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.60291
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IH-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SKM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33881
Dravet syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3162-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.002088
Parasympathetic ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.902
GSE70935_2_v_4_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Magnocellular reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43619
r9 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06427
TMEM115	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61758
Dorsomedial nucleus of the hypothalamus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48957
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.657054
SH2B3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6517
ChIP_RNF2_22325148	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.87269
Lung adenocarcinoma_LUAD_TCGA-91-8499-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4773	TargetScan Predicted Conserved microRNA Targets	1.0	0.042355
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.840093
MDAMB436	CCLE Cell Line Gene CNV Profiles	1.0	1.53694
RAP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95518
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.91518
CHD2	ENCODE Transcription Factor Targets	1.0	null
Presynapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.816
IRF3	ENCODE Transcription Factor Targets	1.0	null
intracranial arterial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.356709
CPZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39658
cation channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H4C6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.70545
valinomycin-5962	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HOXA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92764
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8218
RAB6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93003
MTF2	ChEA Transcription Factor Targets	1.0	null
ethisterone-2326	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Dorsal striatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.016
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE176008_0_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE88819_11_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
APBA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73436
GSE189834,GSE189836_1_v_0_brd4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	113.52
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180200,GSE180201_5_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
ANKZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55118
H3K9me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
USP16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21003
Autoimmune disease of endocrine system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
rectum	HPA Tissue Protein Expression Profiles	1.0	0.756656
Primary motor area, Layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0547
NCI-H358	COSMIC Cell Line Gene Mutation Profiles	1.0	null
scoulerine-5111	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Neurod2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.7284
superficial stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.27819
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.41183
NCKAP5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86744
ALDH18A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70625
Transmembrane transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
spike	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.899871
PMC5444746-oncotarget-08-30328-s002.xlsx-SI01_ChIPSeq_H3K9me_AR-Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_11481_Mut_hMFN2_SRP152949	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.35179
SLC8A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5781
GSE131161_1_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Inner hair cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.747
Perturb_629_KO_SOX4_ERP117895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.2741
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041839
Brain Lower Grade Glioma_LGG_TCGA-HT-7604-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
peripeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16218
TCEAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71737
increased circulating triglyceride level	MPO Gene-Phenotype Associations	1.0	null
LEF1-29337183-MESC-MOUSE-STEM	ChEA Transcription Factor Targets 2022	1.0	null
H3C4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23516
MT-ND6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93334
Taenia tecta, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42281
SESN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61938
GSE120612_6_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TCF23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6617
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.879882
HMGA2	MSigDB Cancer Gene Co-expression Modules	1.0	null
hsa-miR-4312	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
r9 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.00297
Ataxia	DisGeNET Gene-Phenotype Associations	1.0	null
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.910242
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
enilconazole-5113	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SOX9	ChEA Transcription Factor Targets	1.0	null
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.391553
metencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.576415
FGD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96266
heart	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.250953
Internode region of axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.192
NCIH838	Achilles Cell Line Gene Essentiality Profiles	1.0	1.03387
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04729
C1orf50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07171
golgi stack	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.185777
RCC10RGB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PFSK1	DepMap CRISPR Gene Dependency	1.0	3.53063
FOXK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7147
CCDC115	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20875
purkinje layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.456055
MED23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42893
GSE184892_7_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4756-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.013856
TMSB15A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01922
OVKATE	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37394
Perturb_9822_KD_RUNX1_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Lung adenocarcinoma_LUAD_TCGA-75-5147-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PATZ1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	185.196
hsa-miR-345	TargetScan Predicted Conserved microRNA Targets	1.0	0.009975
muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.491791
GSE110268_2_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MOLM14	DepMap CRISPR Gene Dependency	1.0	4.42248
PI4K2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70991
PRDX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31743
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.7268
DIP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00667
GSE188570,GSE188571_3_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
18537972-TableS2	GeneSigDB Published Gene Signatures	1.0	null
CAS1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.5205
GSE133213_11_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206729_2_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210580_3_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06517
vascular tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.113398
hnf4a_16714383_e18dot5_liver_lof_mouse_gpl1261_gds1916	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.15838
neuromuscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.315366
LNCAP	BioGPS Cell Line Gene Expression Profiles	1.0	1.15335
MYBL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66584
ADAM17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1056
MAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8956
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZD-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062203
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.44769
primary auditory cortex (core)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15639
inner CP in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08369
hsa-miR-4649-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.059817
GSE210580_3_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH524	CCLE Cell Line Gene Expression Profiles	-1.0	-2.53244
Lung squamous cell carcinoma_LUSC_TCGA-22-5471-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Medulla oblongata	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.096
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8E-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_KO_3T3_ONLY_2084_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
estradiol-2668	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCIH146	CCLE Cell Line Gene Expression Profiles	1.0	1.65683
retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.108958
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09245
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
white matter of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29961
VSNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2851
Rheumatoid arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.28
GSE176008_8_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34166
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.66
ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
LY-294002-5576	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inner SZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.877953
regulation of ion transport	GO Biological Process Annotations 2015	1.0	null
LS123	CCLE Cell Line Gene CNV Profiles	1.0	1.47931
DDX21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09039
Medial preoptic nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87254
EGR1	ENCODE Transcription Factor Targets	1.0	null
RNF2-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MRPL50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64013
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.977909
CITED2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0504
TCF12	ENCODE Transcription Factor Targets	1.0	null
ion channel complex	GO Cellular Component Annotations 2015	1.0	null
T47D	CCLE Cell Line Gene CNV Profiles	-1.0	-2.20313
NCIH2141	CCLE Cell Line Gene CNV Profiles	1.0	1.35123
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100281_HIP_probable Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.05403
SH3GLB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69872
venom	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.0859
RUNX1-17652178-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MOB3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22942
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
crig1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.674
NCIH1993	DepMap CRISPR Gene Dependency	1.0	2.89702
POLQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85922
SLC23A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79878
Intercalated disc	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.654
TBX2-33478486-IMR90-HUMAN-LUNG	ChEA Transcription Factor Targets 2022	1.0	null
ESO51	COSMIC Cell Line Gene Mutation Profiles	1.0	null
vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.056998
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-0.925319
SUZ12-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.41306
outer CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.98691
FXYD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68972
PSMD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57071
NUDT16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57288
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.1169
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
F5	CCLE Cell Line Gene Expression Profiles	1.0	1.37646
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.880591
single-organism process	GO Biological Process Annotations 2015	1.0	null
ADD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3249
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	112.011
PEBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64743
TGFBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75271
Cytosol	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
parvocellular part of the r9LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.11351
PDE7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91809
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07857
PPM1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21869
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8801
GCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92297
Perturb_14927_Mut_Atxn1_SRP148491	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.94027
anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.45885
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.74147
Pyramus (VIII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85027
superficial stratum of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52866
TXNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24028
monovalent inorganic cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectal Mucosa Donor 31	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.80869
MTF2-20144788-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.88285
Leii	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.835
Absence epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
Perturb_4722_KO_Smarcc1/Smarcc2_SRP124677	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.6591
BARX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06207
Autoimmune disease of central nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.802
neoplasms	GeneRIF Biological Term Annotations	1.0	null
Inward rectifying potassium channel	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.517
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4492	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
CAOV3	CCLE Cell Line Gene CNV Profiles	1.0	1.40199
TNFAIP8L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77234
TRA2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34052
corpus striatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.257907
ZNF320	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88534
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.227707
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_628_KO_HOXD3_ERP117895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.68031
R3HDM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68173
Acute Myeloid Leukemia_LAML_TCGA-AB-2806-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.88307
GLI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44036
sinus node	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.61175
compact myelin	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.338884
OC-314	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE200352_11_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BANF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75243
Lung squamous cell carcinoma_LUSC_TCGA-33-4533-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE180200,GSE180201_2_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UACC812	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.639596
SNU119	CCLE Cell Line Gene Expression Profiles	-1.0	-1.7519
mRNA_GADD45A_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
SOX2-19030024-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H2AC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52059
ARHGAP35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17222
Hemispheric regions	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19141
DorsalRootGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.10831
TT2609C02	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52829
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965799
NCIH2073	CCLE Cell Line Gene CNV Profiles	-1.0	-1.99495
hsa-miR-4458	TargetScan Predicted Conserved microRNA Targets	1.0	0.02452
HDAC2	ENCODE Transcription Factor Targets	1.0	null
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.149047
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF292	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28047
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186065_0_v_1_sirt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PA-TU-8902	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.45191
GSE179036_1_v_0_trim24_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FAM219B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8895
W-13-643	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OAW42	DepMap CRISPR Gene Dependency	1.0	2.71662
RBM19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15643
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0429
RNF207	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09188
increased triglyceride level	MPO Gene-Phenotype Associations	1.0	null
H3K4me1_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.5
HOP92	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.5036
huntington's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.530768
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6ZZ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MBD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04849
INA6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43523
NCOR-22424771-293T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TEDISAMIL	DGIdb Drug Targets 2026	1.0	0.13233
Right atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.045
gastrointestinal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067118
Integral component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
cefsulodin-2988	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
neuron projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.750452
RUSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62171
H3K27me3_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65664
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Α-DENDROTOXIN	DGIdb Drug Targets 2026	1.0	5.2932
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
VEZT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39474
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04533
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.512
amygdaloid complex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.838769
CRELD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49323
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-1304	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
EMX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.12962
lingual gyrus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.870375
Sinus node	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.152
mRNA_NR5A2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.935832
nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.186087
GSE133087_5_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pyramidal neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.639
H3K9me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
outer portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.960078
signaling	GO Biological Process Annotations 2015	1.0	null
USP24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02449
FBXO45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51507
LC1SQ	DepMap CRISPR Gene Dependency	1.0	10.2988
cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.08796
Spinal cord primitive neuroectodermal neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
CingulateCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.96298
SP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	123.876
GABRA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5047
prostate gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074617
single organism signaling	GO Biological Process Annotations 2015	1.0	null
Cnida	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.222
inorganic ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
neurologic	GeneRIF Biological Term Annotations	1.0	null
GABA receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.278
peripheral nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.572018
Brain Lower Grade Glioma_LGG_TCGA-HT-7680-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate stratum of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07134
mammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21159
temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.729385
reserpine-3341	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF705D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79553
GM97	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.18898
arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.111127
Ventromedial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28542
hsa-miR-4772-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
SP in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.972246
Myelinating Schwann cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
Chorea Acanthocytosis Syndrome	DisGeNET Gene-Disease Associations	1.0	null
Glial cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.998
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
COL8A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47628
FADU	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cortex of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21572
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.992777
ZNF674	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80907
medial part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43619
PBX1	ChEA Transcription Factor Targets	1.0	null
GSE211983_0_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52076
ZNF23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96848
prepontine hindbrain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0385
vascular dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.403064
Cell projection membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.3
GALNT12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97123
LOVO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.923266
DLG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.35561
cingulate gyrus, parietal part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.860598
KLF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27464
Folium-tuber vermis (VII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82277
Perturb_4474_OE_Smn_SRP258674	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.76857
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4345-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NPY5R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35807
Kidney renal clear cell carcinoma_KIRC_TCGA-6D-AA2E-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
spinal root	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.274394
Duchenne muscular dystrophy (DMD)_Muscle - Striated (Skeletal) (MMHCC)_GSE1025	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.67281
GSE119345_0_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.79053
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11034
SAP30BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33334
POLR2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28638
thalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.124287
SUZ12	ChEA Transcription Factor Targets	1.0	null
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2886-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J9-A52E-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAPAN-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25703
MOSPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.454
CIB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1548
Cerebellar nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.309
PELI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99235
ELK4	JASPAR Predicted Transcription Factor Targets	1.0	null
SUZ12-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cation transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
outer CP in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38512
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSPA12B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69252
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.2282
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.943427
biological regulation	GO Biological Process Annotations 2015	1.0	null
PMC5259899-13287_2016_455_MOESM2_ESM.xlsx-Up-regulated-Supplementary_Table_S2_Up-reguated_genes_expression_in_MESP1_positive_cells_MESP1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CERS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17536
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.52127
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
COQ3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73815
Perturb_625_KD_IGF2BP3_SRP068523	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.60088
Electrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.157
inner CP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.943382
PANC1005	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.27173
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.21598
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3467-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4773428-ncomms10751-s5.xlsx-S_Table_4-Supplementary_Data_4_RUNX1_responsive_genes_in_the_presence_and_absence_of_estradiol_E2_in_MCF7_cells_FC_1_5_p_0_05_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
encephalitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.229716
hsa-miR-3202	TargetScan Predicted Conserved microRNA Targets	1.0	0.015875
liver	HPA Tissue Gene Expression Profiles	-1.0	-0.950738
inner SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.16183
hsa-miR-4516	TargetScan Predicted Conserved microRNA Targets	1.0	0.002088
GSE131649_6_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-3667-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.107229
Interneuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.692
GSE89057_0_v_1_sox5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120612_4_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
superficial stratum of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32788
adrenal_4a	HPA Tissue Sample Gene Expression Profiles	1.0	0.964778
CCDC43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04891
CDK5RAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89486
Colon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.24
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	1.0	0.89189
DST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42859
GSE143782_3_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ventromedial hypothalamic nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69497
caudal group of intralaminar nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.898327
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM169	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88272
HASPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68982
GSE180200,GSE180201_12_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.25587
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TBK1_druginhibition_188_GSE53658	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.41351
NCIH1755	CCLE Cell Line Gene CNV Profiles	-1.0	-2.45322
Perturb_9820_KD_LMO1_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.6989
subthalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02565
Perturb_4182_KO_Foxp1_SRP102696	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.30538
AJM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83821
MFNG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64608
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6795-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
vgkc	GeneRIF Biological Term Annotations	1.0	null
paroxetine-4378	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.053619
Ahr::Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.625
plexiform layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0719
P12ICHIKAWA	CCLE Cell Line Gene Expression Profiles	1.0	1.39165
potassium ion transmembrane transport	GO Biological Process Annotations 2023	1.0	null
Arterial smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.497
posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07347
VIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.96086
Brain Lower Grade Glioma_LGG_TCGA-HT-7611-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
thyroid_5b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.15697
GR-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.83601
TETRAMETHYLAMMONIUM	DGIdb Drug Targets 2026	1.0	0.294067
TPM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25222
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GDF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28767
GSE211983_0_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4667-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
GSE156667_0_v_1_lrrc8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042438
YTHDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42438
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.75
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.69535
Deutocerebrum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.066
H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
abnormal thermal nociception	MPO Gene-Phenotype Associations	1.0	null
Demyelinating disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.644
embryoday8.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.829444
GSE113106_2_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Voltage-dependent channel, four helix bundle domain	InterPro Predicted Protein Domain Annotations	1.0	null
PMC8569982-41065_2021_205_MOESM1_ESM.xlsx-mono_THP1_a2b_tpm1-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
Huntington Disease	DisGeNET Gene-Disease Associations	1.0	null
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_5_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
hypocotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064804
renal inner medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.616183
TRIM28-19339689-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
CST complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.593
tetraethylammonium	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
GSE174586_0_v_1_slc4a11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6930440-jcav11p0520s3.xlsx-MI_vs_FG-Unnamed_0_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98075
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
DBTRG05MG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83683
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5948
proadifen-3446	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0445
disease by infectious agent	GWASdb SNP-Disease Associations	1.0	0.119406
SNRNP70	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41306
MAZ	ENCODE Transcription Factor Targets	1.0	null
GSE256181_2_v_3_etv2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Purkinje layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.836
COLO680N	CCLE Cell Line Gene Expression Profiles	-1.0	-2.05661
ATP6AP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9347
Neonatal period electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
SMIM12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11463
posteroventral (inferior) parietal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00213
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-g-Classification_of_camel_SON_basal_genes_-_ion_channels_SON	Rummagene Transcription Factor Associations 2026	1.0	null
TMK-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE88819_3_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Spinal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.531
Aortic body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.067
cation transport	GO Biological Process Annotations 2015	1.0	null
14768006-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.959697
C2orf74	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60171
hsa-miR-3672	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
DMS53	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
ALG10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44918
rgm-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.02732
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09826
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-regulation_of_membrane_potential_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.997279
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.48816
CTCF	ENCODE Transcription Factor Targets	1.0	null
Perturb_14146_KO|KD_KBTBD4|RCOR1_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.9495
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
spinal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.242054
GSE147876,GSE147877_2_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.334
Pollen tube	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.628
SNU1214	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45146
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.959697
GBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53496
internal granular layer of CbVCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5547
Tentacle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.341
Severe acute respiratory syndrome (SARS)_Peripheral blood mononuclear cell_GSE1739	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.86713
GSE215351,GSE215794_1_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.15847
RAB11FIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.433
STEAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79738
left ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.217346
Perturb_9042_KO_UTX/JMJD3_SRP158713	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
zona incerta	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.831819
GSE254155_1_v_0_per2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ILF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.21798
HARBI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55987
other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.224645
SUZ12-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_640_KD_FASTKD1_SRP299801	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.02704
transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.00859
ZNF343	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92054
Lobule II, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14515
GSE133070_3_v_1_prss1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88446
adenosine phosphate-3237	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE217115_2_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.72755
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UQCR11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6181
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-8640-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer CP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60009
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE245270_1_v_0_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Temporal lobe epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.405
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.56946
IKZF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.920731
PEX13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12123
hsa-miR-3934	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
HES7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51707
myelencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.117638
voltage-gated potassium channel complex	GO Cellular Component Annotations 2023	1.0	null
TBL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43888
monastrol-605	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SARS-CoV_24Hour_20090954_GSE17400	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.72551
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Paranodal junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.271
GSE227891_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-133a	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
NONO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79081
Bladder wall	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.675
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05078
U266B1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7763
Declive (VI)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78845
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
episodic ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.24211
Kna	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.606
Sympathetic chain	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.058
H3K4me1_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pontine gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54329
DPH5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73922
WRNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02755
NINL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71567
Entorhinal area, lateral part, layer 2b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0719
periventricular stratum of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30021
HOXA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57349
alpha-estradiol-702	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
plant embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063776
Lung adenocarcinoma_LUAD_TCGA-49-6743-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.185016
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PTOV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82067
GSE94849_6_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CIP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30734
hsa-miR-4433	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
PDZD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76407
cellular component organization	GO Biological Process Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8139-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CAMA1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40016
clioquinol-4663	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
voltage-gated potassium channel activity	GO Molecular Function Annotations 2015	1.0	null
GSE149880_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE156923_2_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PEA15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67979
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.40261
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
JEKO1	CCLE Cell Line Gene Expression Profiles	1.0	1.40242
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.64462
MAPK8IP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07778
SKMEL1	CCLE Cell Line Gene CNV Profiles	1.0	2.36323
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Potassium channel, voltage dependent, Kv	InterPro Predicted Protein Domain Annotations	1.0	null
IKZF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64067
cardiofibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.451813
Temporomandibular joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.83
Terminal loop	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.816
EBC1	DepMap CRISPR Gene Dependency	1.0	2.47721
NFIC	ENCODE Transcription Factor Targets	1.0	null
ZNF780B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69953
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.751645
external granular (germinal) layer of upper rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.82006
Perturb_9819_KD_HEB_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.54398
GCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84082
METTL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84721
H2BC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19636
Mesenterial filament	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.493
Ventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30288
SP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.52301
SW48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RNF2-18974828-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
KLM1	CCLE Cell Line Gene CNV Profiles	1.0	1.35223
mammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21036
GSE210580_4_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.95898
Perturb_4165_KO_Mir29_SRP229364	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.70261
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058487
GSE261563_9_v_4_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE167373_2_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120612_7_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ABI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34139
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OXCT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52027
venom apparatus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.194479
macroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.442578
hsa-miR-612	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
IDH3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12572
delayed rectifier potassium channel activity	GO Molecular Function Annotations 2023	1.0	null
ZKSCAN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33004
TLCD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83439
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ROCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39457
SUZ12-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE142684_2_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Vestibular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.956
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04046
HCN channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.842
PCNT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32272
NCS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93274
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22746
anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16994
H3K27me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A7R2-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
propidium iodide-6104	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
inorganic cation transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GSE200839,GSE233826_3_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
NTERA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42607
embryoday9.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.46112
ACBD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13581
LMSU	DepMap CRISPR Gene Dependency	1.0	6.37366
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE118617,GSE118619_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90887
monoatomic cation transmembrane transport	GO Biological Process Annotations 2023	1.0	null
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.410491
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GIT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33838
Acute Myeloid Leukemia_LAML_TCGA-AB-2930-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8422-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IKZF1	ENCODE Transcription Factor Targets	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
fulvestrant-7534	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MYD88_Deficiency_GDS2650_652_mouse_LUNG	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
r3 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14786
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.88307
Mesothelioma_MESO_TCGA-SC-A6LM-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cochlear ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.309
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
heart ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.180195
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.603
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gastric epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.48048
NELFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41357
Carotid sinus nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.861
mRNA_OTX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03266
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.602752
PTPN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56533
NFYB	ENCODE Transcription Factor Targets	1.0	null
ZSCAN5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2354
WDR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22282
RGL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78106
ChIP_TRIM28_19339689	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Central medial thalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.209
ZNF644	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46021
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.446935
ChIP_SUZ12_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Trigeminal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.582
UGT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07234
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SO-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CIAO2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04757
Perturb_1162_KD_E2APBX1_SRP115954	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.39392
SIN3A	ENCODE Transcription Factor Targets	1.0	null
lisuride-6682	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-132	TargetScan Predicted Conserved microRNA Targets	1.0	0.042355
PMC13082837-NIHMS2159075-supplement-3.xlsx-DataTable5_Methylation_LMS-UCSC_RefGene_Name_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
r3 part of anteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4964
MDAMB157	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67781
abnormality of immune system physiology	GWASdb SNP-Phenotype Associations	1.0	0.082829
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Vestibular calyx terminal	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.058
PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171352_2_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14053
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AMIFAMPRIDINE	DGIdb Drug Targets 2026	1.0	0.126029
FIGNL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94237
Cnidoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.629
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.4122
cell type benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046306
duodenum	HPA Tissue Protein Expression Profiles	1.0	0.756656
cochlea	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.224645
seedling	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063776
PMC10713402-aging-15-205220-s005.docx-0-RBAK_RBAK	Rummagene Transcription Factor Associations 2026	1.0	null
PAK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13253
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rck2	GeneRIF Biological Term Annotations	1.0	null
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.602892
core part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10992
GSE142684_0_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180200,GSE180201_2_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.92996
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-499a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.047969
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K27me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6078853-molce-41-7-695-suppl2.xlsx-Sheet1-Table_S1_Genes_exhibiting_two-fold_changes_in_expression_between_WT_and_CTCF_KO_otocyst_with_FDR_less_than_0_05_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
frontal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.304279
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FZD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86187
central part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48351
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RNF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88738
EBC1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.01226
immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.050853
ventrolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24152
MAST CELL DEGRANULATING PEPTIDE	DGIdb Drug Targets 2026	1.0	5.2932
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Venom apparatus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.929
HCC1171	CCLE Cell Line Gene Expression Profiles	-1.0	-1.95308
C3orf80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11113
SCL-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE207611,GSE207612_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
semicircular canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.437205
A1207	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.39007
GSE210580_3_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Choreoathetosis	DisGeNET Gene-Disease Associations	1.0	null
sulfapyridine-6101	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
trigeminal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.13889
MDAMB436	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.76543
BMAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29187
POGK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17246
RNF114	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11493
periventricular stratum of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10936
Telson	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.051
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE193351_1_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63819
HSP90AA1	Pathway Commons Protein-Protein Interactions	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
mRNA_CBX8_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Skeletal Muscle Female	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.89527
RMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48836
ChIP_MTF2_20144788	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
ADAM19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24819
BATF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Piriform area	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.119
HIF1AN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14777
COPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87667
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.835
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.905
PHACTR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21803
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063809
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.930047
SKLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.42819
hsa-miR-1299	TargetScan Predicted Conserved microRNA Targets	1.0	0.008128
CAOV4	DepMap CRISPR Gene Dependency	1.0	2.30922
Periventricular nucleus of hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.008
GSE92965_0_v_1_klf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
astrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.257907
chr12_4828409_G_T_b38	GTEx eQTL 2025	1.0	1.10023
IMCD cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.695
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5183-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Differentially_expressed_genes_identified_in_bulk_RNA-seq_of_FOXO1-_-_vs_FOXO1_hMSCs_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
HOXD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39323
RUNX1-17652178-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
cell periphery	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GJB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81416
CP in rostral hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.833085
hsa-miR-3925-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Perturb_14145_KO_KBTBD4_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.32429
vomeralnasalorgan.VMO.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46753
substrate-specific transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
H3K9me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12670081-mct-24-0704_supplementary_table_s10_suppst10.xlsx-Supplementary_Table_S10-Supplementary_Table_S10_Differential_expression_of_TFCP2-rearranged_RMS_Vs_Other_RMS_FC_3_padj_0_01_TFCP2	Rummagene Transcription Factor Associations 2026	1.0	null
Long QT syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.51
FAM161A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29615
GNG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02421
adrenal_4d	HPA Tissue Sample Gene Expression Profiles	1.0	1.16349
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE176008_7_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7473-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MFE280	CCLE Cell Line Gene Expression Profiles	1.0	1.43558
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.949428
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34166
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RING1B-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.219057
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5083212-NIHMS69767-supplement-Supplementary_Table_1.xlsx-Sup_Table1-Supplementary_Table_1_Human_brain_and_nervous_system_pathologies_associated_with_genes_present_in_the_TSHZ3_coexpression_module_TSHZ3	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
DNAJC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73808
piriform area	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.213471
RAB18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84957
SYO1	DepMap CRISPR Gene Dependency	1.0	2.0734
NUDT4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32856
TULP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17944
Meningococcal infection_Umbilical vein_GSE4646	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.42318
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.894554
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16919
nephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.168873
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.79053
hsa-miR-4506	TargetScan Predicted Conserved microRNA Targets	1.0	0.031759
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.383637
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAVER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07952
Lung adenocarcinoma_LUAD_TCGA-55-8507-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BATF	ENCODE Transcription Factor Targets	1.0	null
delayed rectifier potassium channel activity	GO Molecular Function Annotations 2025	1.0	null
HES6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7757
Anteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00767
LRFN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56189
GPBP1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74624
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Postpiriform transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11045
Brain Lower Grade Glioma_LGG_TCGA-FG-6691-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EPN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99321
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.59679
GSE189653,GSE203344_2_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
VDR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73972
bkca	GeneRIF Biological Term Annotations	1.0	null
Perturb_6180_Mut_Mecp2_SRP188207	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.36716
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18176
orbital frontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.89882
E2F3_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
MRRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04924
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5546-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NFYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4963
H4K20me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Hippocampal pyramidal layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.639
LAMA84	Achilles Cell Line Gene Essentiality Profiles	1.0	1.1498
dorsal tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07246
cation channel complex	GO Cellular Component Annotations 2023	1.0	null
XYLT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18985
GSE240386,GSE242143_1_v_5_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.04626
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7758
cation channel complex	GO Cellular Component Annotations 2015	1.0	null
HECTD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84278
Mesenteric artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.149
ARMC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98147
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075867
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01349
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10179
localization	GO Biological Process Annotations 2015	1.0	null
RNF187	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70543
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SATB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.18576
suprachiasmatic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6901
CREBRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96022
GABA-A receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.243
PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
NOM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42354
interneuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.725274
Mesothelioma_MESO_TCGA-LK-A4NZ-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_631_KO_SOX4_ERP117895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.414
TMEM151A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26996
thymoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.384079
ARHGAP45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27902
SKCO1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.29444
TRIP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19129
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.83601
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
Distal dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.327
THP1	Achilles Cell Line Gene Essentiality Profiles	1.0	2.47786
INSR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39571
LAYN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2792
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13689
EZH2-18974828-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Paramedian lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26297
YMB1	CCLE Cell Line Gene CNV Profiles	1.0	1.57414
rofecoxib-463	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
CCDC117	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54546
Culmen	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59598
PMC7595190-41598_2020_75453_MOESM6_ESM.xlsx-MLL_EFS_groups_DEGs-Symbol_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G4_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
GOLGA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82395
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6134
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SREK1IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11414
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HPAC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16782
Autoimmune disease of the nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.82
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TSPAN14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40616
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
superficial stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.6926
HMEL	CCLE Cell Line Gene Expression Profiles	1.0	1.8678
ShK Toxin	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Perturb_16866_Mut|KO_Htt_SRP255943	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-13.1605
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M6-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
protein complex subunit organization	GO Biological Process Annotations 2015	1.0	null
UQCRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33537
smoothmuscle_8b	HPA Tissue Sample Gene Expression Profiles	1.0	0.89058
GSE131798,GSE131804_1_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
stiff-person syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.750457
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06079
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.945
ALDH4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57167
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.78668
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
MHHES1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.75456
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A216-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
homeostasis/metabolism phenotype	MPO Gene-Phenotype Associations	1.0	null
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PTER	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77138
GSE210870_0_v_2_snai1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_16626_KD_Sod1_SRP217736	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.1966
ChIP_H3K27me3_17603471_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
superficial stratum of r9BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.46866
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE255432_6_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PTP4A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26814
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19684
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
r1 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11929
PHA-00745360-4381	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
superficial stratum of r7BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26569
fallopian tube	HPA Tissue Protein Expression Profiles	1.0	0.756656
GSE224969,GSE224971_3_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cell body	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.421212
PMC9263655-mmc3.xlsx-ZNF436-AS1-Prediction_catRAPID_ZNF436	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal circulating lipid level	MPO Gene-Phenotype Associations	1.0	null
mouth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062339
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
non-myelinating Schwann cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.517
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE94814_2_v_3_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cerebellar cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.508
NSMF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15958
GSE189683_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
integral component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
SARC9371	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K9me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3972	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
cerebellar cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.08278
Utricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.898
OXSM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65849
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.19684
NCIH2227	CCLE Cell Line Gene Expression Profiles	1.0	1.38515
Syntrophin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.718
GAS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77188
CTCF-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
medial part of r8B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1054
AXIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.39929
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
KYO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35845
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Dorsomedial nucleus of the hypothalamus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31244
NB13	DepMap CRISPR Gene Dependency	1.0	2.55112
EFO21	CCLE Cell Line Gene CNV Profiles	-1.0	-1.9776
disease	GWASdb SNP-Disease Associations	1.0	0.023873
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
chorea-acanthocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.05765
primary auditory cortex (core)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.945725
thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.121983
IVNS1ABP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80791
ganglion cell layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.465723
dorsal motor nucleus of the vagus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.896456
SAR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37969
Ventral premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32858
chr12_4824561_A_G_b38	GTEx eQTL 2025	1.0	2.00259
hsa-miR-4434	TargetScan Predicted Conserved microRNA Targets	1.0	0.003282
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32214
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.28654
inner medullary collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.237216
Autoimmune disease of musculoskeletal system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.299
Perturb_9814_KD_TAL1_SRP062773	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Subparaventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76854
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.269
superficial stratum of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21622
inferior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.7166
NFIA_Deficiency_GDS2775_639_mouse_Embryonic brains (at E18)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-429-BATF3_BATF3	Rummagene Transcription Factor Associations 2026	1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
Stratum lucidum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.77
heart	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.868009
NG-108-15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
HOXB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5376
dorsal cortical nucleus of inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03717
HEXD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26687
juxtaglomerular apparatus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.180997
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE174498,GSE174500_5_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.9022
voltage-gated potassium channel activity	GO Molecular Function Annotations 2025	1.0	null
DMS-53	COSMIC Cell Line Gene CNV Profiles	1.0	2.64759
Posterior adductor muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.624
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
Cell periphery	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.532
hsa-miR-3921	TargetScan Predicted Conserved microRNA Targets	1.0	0.159923
GSE138001_2_v_3_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ACYP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09156
modiolus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.226926
GSE135334,GSE136010_2_v_3_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.144334
SU-DHL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04417
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23663
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06068
Spinal nucleus of the trigeminal, oral part, ventrolateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22442
SLC43A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77258
SLC27A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02024
GSE111660_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE232631_0_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CPSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56669
Voltage gated Potassium channels	Reactome Pathways 2014	1.0	null
NT5DC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94291
Lateral geniculate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.679
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Collecting duct cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.608
hsa-let-7e	TargetScan Predicted Conserved microRNA Targets	1.0	0.002088
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FV-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PCOLCE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51013
PRDX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54056
Ion channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.108
bonemarrow	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.0358
NAPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5844
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HAC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.636
WSB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0199
H3K4me3_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NERISPIRDINE	DGIdb Drug Targets 2026	1.0	0.105864
locus ceruleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.35023
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.668992
kidney	HPA Tissue Protein Expression Profiles	-1.0	-0.925319
NKX6-3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40112
DPEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54616
APOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24906
OCIAML3	Achilles Cell Line Gene Essentiality Profiles	1.0	1.01635
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.91159
ZNF44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79497
LMNB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41803
GSE205163,GSE205164_3_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Renal medulla cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.684
ChIP_RNF2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
mantle zone of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.90727
TMEM52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47065
TBC1D10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92403
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0757
hsa-miR-1913	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
hsa-miR-759	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.943281
hsa-miR-4533	TargetScan Predicted Conserved microRNA Targets	1.0	0.031759
SOX9-25088423-EMBRYONIC GONADS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE152441,GSE152442_0_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OVMIU	DepMap CRISPR Gene Dependency	1.0	3.49263
r3 part of trigeminal transition zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05053
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
mRNA_SOX9_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PMC10290283-biol-2022-0622-sm3.pdf-493-HOXC10_HOXC10	Rummagene Transcription Factor Associations 2026	1.0	null
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.70819
Perturb_18392_KO_923large_SRP286259	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.50655
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.63887
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.44149
abnormal triglyceride level	MPO Gene-Phenotype Associations	1.0	null
HTR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57928
central medial thalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.20956
neck	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057751
pheneticillin-6105	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
plumule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065258
ITPRID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15805
Inferior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.87515
Lung adenocarcinoma_LUAD_TCGA-44-5644-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Checkpoint clamp complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.397
dactinomycin_homo sapiens_gpl7172_gse12459	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superficial stratum of r4BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57679
Amnestic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
SDF2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87546
GSE223334_1_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-24	TargetScan Predicted Conserved microRNA Targets	1.0	0.241055
LIMD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63797
PATU8902	CCLE Cell Line Gene CNV Profiles	1.0	2.59998
gastric cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.24676
medial mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31108
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.21535
abnormality of the immune system	GWASdb SNP-Phenotype Associations	1.0	0.052867
ERG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23452
gastric epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.371994
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.9688
ARHGEF40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86122
DG-75	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ERCC4	MSigDB Cancer Gene Co-expression Modules	1.0	null
ORC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92685
GSE207611,GSE207612_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4111
TRIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19863
GSE188570,GSE188571_3_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gastrointestinal stromal tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.523
Medullary collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.801
EAPP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61087
posteroventral (inferior) parietal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.897644
KCTD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07083
PPM1N	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7115
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75812
IZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.952144
GSE219195_0_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
INA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.826
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
TSPAN13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56498
gastric cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085295
PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
gastrointestinal stromal tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.604904
integument phenotype	MPO Gene-Phenotype Associations	1.0	null
cingulate gyrus, parietal part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11302
UHRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28941
11-deoxy-16,16-dimethylprostaglandin E2-7533	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ChIP_SUZ12_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965799
neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.183248
Axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.104
NCIH810	CCLE Cell Line Gene Expression Profiles	1.0	2.02457
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.67
SP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.47973
spinocerebellar degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.285444
voltage-gated ion channel activity	GO Molecular Function Annotations 2015	1.0	null
ChIP_JARID2_20075857	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
r9 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08698
NCI-H1105	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_16864_KO_Hdac2_SRP255943	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.3455
GSE233679_5_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.967647
Ebolavirus(EBOV)_1day_Splenocytes_19683682_GSE17509	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.66703
Tail	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.433
Potassium Channels	Reactome Pathways 2014	1.0	null
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.899679
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE219195_1_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19025
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	181.769
Spike	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.637
renal medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.206299
NOBOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10526
SH3BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50494
SMYD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30658
ventrolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.994489
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MESP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13206
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.930079
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5528
H3K27me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.05803
cerebellar vermis	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17574
MYRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28008
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.99182
Brain Lower Grade Glioma_LGG_TCGA-HW-A5KM-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chlorcyclizine-3810	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lateral subdivision of area 9	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28457
GSE180200,GSE180201_3_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120612_6_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
Perturb_610_KO_SLFN11_SRP233181	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.43686
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
striatum_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07055
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH23	CCLE Cell Line Gene CNV Profiles	1.0	1.44872
metal ion transport	GO Biological Process Annotations 2015	1.0	null
CAL51	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.11229
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GOLGA8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80561
Perturb_622_KD_GATA3_SRP372594	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.78328
Anteroventral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65341
MX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10214
GSE135350_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
TRIM62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36938
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16925
FAM236B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47945
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.86
mRNA_TUBA1A_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Cation channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
21205295-TableS1	GeneSigDB Published Gene Signatures	1.0	null
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04533
fenbufen-2308	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
gastrointestinal stromal tumor	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.335046
SKOV3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45258
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.10756
PRRT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46675
intermediate stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32434
Adrenocortical carcinoma_ACC_TCGA-OR-A5JY-01A-31R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_16943_OE_Mir181a1_SRP359086	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.145
P12ICHIKAWA	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35722
FAM217B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48737
neuron projection terminus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.657326
SNAI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4594
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216538_7_v_2_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TCF4	ChEA Transcription Factor Targets	1.0	null
ChIP_SOX2_19030024	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.636
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
NOS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69046
SLC25A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56868
SPTBN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08884
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.09253
voltage-gated sodium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.284
AOC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0174
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.96813
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056211
calcium	GeneRIF Biological Term Annotations	1.0	null
golgi apparatus part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.05955
parvocellular part of r8LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85235
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
salivary gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.126304
PSIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90579
LHX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84531
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
heart muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.95453
GSE171177,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cation channel complex	GO Cellular Component Annotations 2025	1.0	null
MDAMB361	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.55445
CITED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64327
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.83238
GSE97352_3_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neuroma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04288
XYLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60922
KLF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.9518
hsa-miR-3663-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
SIN3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79896
superficial stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4947
ISY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.16228
superficial stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.75472
Electric organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.425
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
spectrum	GeneRIF Biological Term Annotations	1.0	null
SHH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52199
JARID2	ChEA Transcription Factor Targets	1.0	null
OCUM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-4786-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.009975
GSE186287_1_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-FX-A3NK-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
[<sup>125</sup>I]BgK (W5Y / Y26F)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085164
496100332_HIP_possible Alzheimer's disease_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13017
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.38493
Adrenocortical carcinoma_ACC_TCGA-OR-A5J3-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202284,GSE202289_3_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Urinary bladder smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.796
ZBTB7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73625
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.38303
increased circulating triglyceride level	MGI Mouse Phenotype Associations 2023	1.0	null
TFCP2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86946
ACOT13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70082
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JARID2-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22746
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42927
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.873858
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE240386,GSE242143_8_v_4_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CCNJL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52566
YARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8258
Cortical amygdalar area, posterior part, lateral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.08394
Pancreatic adenocarcinoma_PAAD_TCGA-US-A776-01A-13R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF608	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99953
GSE142684_3_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_14_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.766125
GSE138863_2_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.43753
hsa-miR-3974	TargetScan Predicted Conserved microRNA Targets	1.0	0.23348
ventrolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.840099
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_PHC1_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04533
hsa-miR-127-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Peripheral ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.53
MCF7	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.876945
Atrial appendage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.565
KDM4E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51274
Lung squamous cell carcinoma_LUSC_TCGA-21-1083-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CARNS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79548
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.973145
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4756-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
carotid body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223419
IGR1	CCLE Cell Line Gene CNV Profiles	1.0	1.45451
CORL95	CCLE Cell Line Gene Expression Profiles	1.0	2.1891
Gracilis muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.654
POU2F2	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Purkinje cell layer of CbVCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41404
NCI-H1703	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SESN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93288
ChIP_SUZ12_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JHESOAD1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.0592
SOX11-22085726-ESNS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SYAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02541
APH1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46543
IZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.86016
Anti-saccade response	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.51549
GFY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88334
OBSCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2021
H3K4me1_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CFAP157	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48509
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.758673
ACAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29844
PDS5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78285
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
MIR122_Antisense Inhibition_GDS1729_759_mouse_Livers (from C57BL/6 adult males)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
vancomycin-4598	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
rostral paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37129
H3K9me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Folium-tuber vermis (VII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.79057
ELN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24352
Episodic ataxia type 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.226
Mesothelioma_MESO_TCGA-MQ-A4LV-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uvula (IX), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72567
RBMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10183
COQ4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76364
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.951407
superficial stratum of r3BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06656
Colorectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.24
ATAD3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.45112
HMGB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59602
bed  nucleus of stria terminalis, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.98528
PEO4	DepMap CRISPR Gene Dependency	1.0	2.1018
GSE180200,GSE180201_2_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
potassium ion transmembrane transport	GO Biological Process Annotations 2025	1.0	null
20458058-TableS3c	GeneSigDB Published Gene Signatures	1.0	null
POLG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4965
Atrioventricular node	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.894
MUSTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62247
PMC5414054-ncomms15013-s11.xlsx-SupplementaryData10-Supplementary_Data_10_Genes_differentially_expressed_due_to_infection_in_IRF5-_-_compared_to_parent_KOLF2_cells_IRF5	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF211	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0894
RB1_KD_GSE50532_641_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
isthmic alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30662
SP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00329
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28702
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
MRFAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94586
intrinsic component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
cranial nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0967
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10495
MYRFL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0212
SH10TC	CCLE Cell Line Gene CNV Profiles	1.0	1.79152
TTC21B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30677
PMC11953390-41598_2025_94761_MOESM1_ESM.xlsx-Table_S3-Table_S3_The_result_of_MR_analysis_and_sensitivity_analysis_for_CKD_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
HS604T	CCLE Cell Line Gene Expression Profiles	1.0	1.7959
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EED-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
latamoxef-4648	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Potassium channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE221955_3_v_2_igfbp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-2467-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
hsa-miR-4308	TargetScan Predicted Conserved microRNA Targets	1.0	0.020071
hsa-miR-1180	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Perturb_15635_KO_MAT2A_SRP351305	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.1585
SF295	BioGPS Cell Line Gene Expression Profiles	1.0	1.27242
CNOT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4742
GSE191015_0_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
HCC-44	COSMIC Cell Line Gene Mutation Profiles	1.0	null
UBR5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15938
cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16995
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.8213
HL60	Achilles Cell Line Gene Essentiality Profiles	1.0	1.67724
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.409787
plant vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.531089
15474998-tableS1c	GeneSigDB Published Gene Signatures	1.0	null
regulation of transport	GO Biological Process Annotations 2015	1.0	null
Eht	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.546
DUSP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78949
SPRYD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43304
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.869362
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120612_7_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
HS870T	CCLE Cell Line Gene Expression Profiles	1.0	1.63486
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.377
hsa-miR-296-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GSE210682_2_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
G protein-coupled GABA receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.643
cellular_component	GO Cellular Component Annotations 2015	1.0	null
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34303
r3 part of medial pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18735
RASA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47658
MMP19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43359
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07021
DMS153	CCLE Cell Line Gene Expression Profiles	1.0	1.69432
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1178	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GSE217115_3_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
potassium ion transport	GO Biological Process Annotations 2025	1.0	null
intrinsic component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE210682_0_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4446-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
CSNK1E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50465
transporter complex	GO Cellular Component Annotations 2015	1.0	null
IGFLR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7619
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01536	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.89826
SP in perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.967688
[<sup>125</sup>I]&alpha;-DTX	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Rectum adenocarcinoma_READ_TCGA-G5-6641-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41794
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.960247
basal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.293866
SIN3B-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5072-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.225395
periventricular stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37282
hek-293 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.529903
PPIG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05138
PFN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69717
Parasympathetic nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.843
CISD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78149
outer SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24024
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.933756
MBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96336
496100584_HIP_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.82816
Uvula (IX)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59688
substrate-specific channel activity	GO Molecular Function Annotations 2015	1.0	null
ESPNL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42107
AP4B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83632
bronchus	HPA Tissue Protein Expression Profiles	1.0	0.756656
VIM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20435
r8 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19667
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.969917
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1422
posteroventral (inferior) parietal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.882764
SUZ12-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_16633_Mut_Tardbp_SRP133158	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.39199
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE238018_3_v_5_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
behavior/neurological phenotype	MPO Gene-Phenotype Associations	1.0	null
496100547_HIP_no dementia_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.43087
EBAG9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73732
CLMP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24788
KP4	CCLE Cell Line Gene CNV Profiles	1.0	1.74998
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
dorsomedial preoptic area, superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.46326
GSE137818_5_v_0_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-5047	TargetScan Predicted Conserved microRNA Targets	1.0	0.015875
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CREB3L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3736
cellular process	GO Biological Process Annotations 2015	1.0	null
HT144	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59384
KCTD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12814
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUGC2	CCLE Cell Line Gene CNV Profiles	1.0	1.82252
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hydrocotarnine-4489	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LUC7L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.122
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.885467
CG-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.593
CCDC163	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.155
action potential	GO Biological Process Annotations 2025	1.0	null
collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.235167
MATCAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5208
GSE157555,GSE157556_4_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-10a	TargetScan Predicted Conserved microRNA Targets	1.0	0.078844
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.31053
periventricular stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39332
thyroid gland	HPA Tissue Gene Expression Profiles	-1.0	-1.29312
hsa-miR-3620	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE210580_3_v_6_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-1912_ChIP-Seq_H3K9me1_2_demethylation_and_ChIP-Seq_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6848-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4941
MTERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07512
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
Lobules IV-V, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64671
TIMM17A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0672
monovalent inorganic cation transport	GO Biological Process Annotations 2015	1.0	null
interventricular septum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.55408
GSE120612_4_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4739	TargetScan Predicted Conserved microRNA Targets	1.0	0.009975
PRDM9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	190.472
regulation of ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40719
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A681-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PSENEN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0363
GSE81803,GSE81912_4_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DMS53	CCLE Cell Line Gene Expression Profiles	1.0	1.34731
hsa-miR-508-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
hsa-miR-3134	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.983121
AKIRIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23497
Lateral loop	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.116
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MMS19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05468
BTB/POZ-like	InterPro Predicted Protein Domain Annotations	1.0	null
PKP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85391
primary motor cortex (area M1, area 4)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.862706
SP in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.943668
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.30254
HDAC6	ENCODE Transcription Factor Targets	1.0	null
MED11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51866
organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.054934
Dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11594
integral component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PMC7587013-GLIA-68-2613-s005.xlsx-ASCL1_Putative_Targets-Overlapping_Genes_ChIP-seq_8791_ASCL1_Assoc_Genes_vs_TCGA_RNA-seq_2136_Top_10_ASCL1-positively_Correlated_Genes_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.932
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
VIIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.92681
titin-telethonin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.839
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
troglitazone-462	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-3074-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r4 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41497
GSE94814_2_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
meptazinol-4188	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCIH196	CCLE Cell Line Gene CNV Profiles	-1.0	-1.95723
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Paranode region of axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.927
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
carotid artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.12765
LONP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35848
SLR24	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.79317
Axolemma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.675
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.77447
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.335778
cerebellar purkinje cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.767783
hsa-miR-1252	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
hsa-miR-3189-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-3.55946
ESS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90323
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.38763
Lung squamous cell carcinoma_LUSC_TCGA-37-4141-01A-02R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AICD_Induced  expression / Over-expression_GDS1979_288_human_SHEP-SF neuroblastoma	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LK-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE70499_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H2-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
macula densa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.341863
leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06599
PCDHB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6115
GSE216538_0_v_2_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebral lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.758259
root	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.09458
superficial stratum of r8BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.11351
increased vertical activity	MGI Mouse Phenotype Associations 2023	1.0	null
HMGB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11614
GSE214931_4_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040444
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6324-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCLY	ChEA Transcription Factor Targets	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8437-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Crus 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38885
KLHDC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.32471
metal ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE136627_2_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
GSE217156_1_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZC3H12C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.782
molecular layer of CbVCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50106
Ansiform lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3223
macromolecular complex assembly	GO Biological Process Annotations 2015	1.0	null
PATU8902	DepMap CRISPR Gene Dependency	1.0	7.28387
QPCTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.46157
hsa-miR-513c	TargetScan Predicted Conserved microRNA Targets	1.0	0.002088
P63-20808887-KERATINOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PK59	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32561
KCTD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10243
GSE189683_1_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.2069
somatic embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.62991
CCDC153	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52988
small intestine	HPA Tissue Protein Expression Profiles	1.0	0.756656
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17846
Tuberomammillary nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18324
USE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66545
hsa-miR-506	TargetScan Predicted Conserved microRNA Targets	1.0	0.136254
GSE164135,GSE164137_0_v_1_fbxw7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.441042
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FANCG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58305
TNK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44576
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.0938
Perturb_16849_KO_Hnrnph1_SRP068520	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.216
AGO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77238
plasma membrane	LOCATE Curated Protein Localization Annotations	1.0	null
GNRH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79704
MONOMAC6	Achilles Cell Line Gene Essentiality Profiles	1.0	1.11137
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
LINS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.2986
Perturb_6431_KD_ADAR_SRP268834	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.31748
ETNK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33914
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16166195-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
tail	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.622235
H4K20me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
Cerebellar Ataxia	DisGeNET Gene-Phenotype Associations	1.0	null
MED13L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47573
r8 part of inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.72568
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-Fay_Heat_LPStoThermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08409
hsa-miR-512-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
Sarcoma_SARC_TCGA-QQ-A8VB-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKMEL5	CCLE Cell Line Gene Expression Profiles	1.0	1.36344
smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.577215
prostate	HPA Tissue Protein Expression Profiles	1.0	0.756656
GATA3-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MAPK1_knockdown_112_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.55098
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_16852_KO_Hnrnph1_SRP068520	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.42312
vagina	HPA Tissue Protein Expression Profiles	-1.0	-0.925319
voltage-gated cation channel activity	GO Molecular Function Annotations 2015	1.0	null
GSE180951_1_v_3_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TEAD4	ChEA Transcription Factor Targets	1.0	null
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060977
valproic acid-2674	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
profenamine-3376	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE111660_1_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRIM28-19339689-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03653
CLDN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61987
hsa-miR-3607-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.003282
AMMECR1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8697
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.93048
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.711319
Focal epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.437
muscle fibre	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.170552
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
496100355_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.36804
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
transmembrane transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.008736
Proximal dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.734
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.16225
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
JJN3	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.13993
Nematocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.478
KCTD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69071
GSE144484_0_v_3_mllt6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04417
GSE104022_3_v_7_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845174
MONOMAC1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.18374
Astrocyte projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.664
midbrain raphe nuclei	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.953252
IRF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Heart conduction disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2955
SARS-CoV MA15_Day2-PFU-10^4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.78803
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0155
PHC1-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Primary somatosensory area, lower limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31799
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBXN2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54147
hsa-miR-4476	TargetScan Predicted Conserved microRNA Targets	1.0	0.069137
TMEM131L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65995
Dentate granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.024
SNB19	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.60085
voltage-gated channel activity	GO Molecular Function Annotations 2015	1.0	null
NDUFAF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52454
channel activity	GO Molecular Function Annotations 2015	1.0	null
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.5831
ZNF345	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83371
Perturb_3497_KD_Lcn2_SRP224700	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.48929
nucleus subputaminalis	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36138
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2437
KCTD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50772
peduncular part of dorsomedial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11705
layer 1 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05867
GSE120612_6_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
chr12_4827418_G_A_b38	GTEx eQTL 2025	1.0	1.06918
Membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.532
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15397
Clark-Baraitser syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.233
H3K27me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
mantle zone of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16949
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FO-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043036
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal sensory capabilities/reflexes/nociception	MPO Gene-Phenotype Associations	1.0	null
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.969408
cellular component assembly	GO Biological Process Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DM-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stomach	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.152346
COA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04559
GSE148658_1_v_0_six6_human	RummaGEO Gene Perturbation Signatures	1.0	null
NFXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30766
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51R-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
P3HR1	CCLE Cell Line Gene Expression Profiles	1.0	1.50503
EBC1	CCLE Cell Line Gene CNV Profiles	1.0	1.33314
lateral hypothalamic area, mammillary region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.897069
HOXD9_01_70	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.57455
GSE236502_1_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MEWO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.83948
skeletal muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.95453
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.174
Perturb_4465_KO_Stat3_SRP251035	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.03695
WDR73	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26411
prostate gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07087
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42167
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
STK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80056
hsa-miR-4300	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
Brain Lower Grade Glioma_LGG_TCGA-DB-5273-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-583	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
electrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.513743
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.838818
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1170_KD_RUNX1_ERP128097	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2M7-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9742_KO_Fxr_SRP241086	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.07251
FNBP1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5188
RETSAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97062
hsa-miR-875-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.026857
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29W-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
flucloxacillin-6507	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H2AC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8066
SUDHL8	DepMap CRISPR Gene Dependency	1.0	2.19242
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05494
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SUZ12-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
viral infectious disease	GWASdb SNP-Disease Associations	1.0	0.192752
NUDHL1	CCLE Cell Line Gene CNV Profiles	1.0	1.4075
USP34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90361
posterior (caudal) superior temporal cortex (area 22c)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17355
PTPRU	MSigDB Cancer Gene Co-expression Modules	1.0	null
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
glial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.412771
HS6ST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94448
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Neurologic Manifestations	DisGeNET Gene-Phenotype Associations	1.0	null
increased vertical activity	IMPC Knockout Mouse Phenotypes	1.0	null
voltage-gated potassium channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.11818
ZNF841	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87216
Benign Hereditary Chorea	DisGeNET Gene-Disease Associations	1.0	null
voltage-gated monoatomic cation channel activity	GO Molecular Function Annotations 2023	1.0	null
manifestations	GeneRIF Biological Term Annotations	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE197686,GSE197688_2_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE92965_0_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16928
T3M4	BioGPS Cell Line Gene Expression Profiles	1.0	1.42972
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133213_2_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PL4	COSMIC Cell Line Gene CNV Profiles	1.0	2.64759
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.333396
H3K18ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.903858
CORL105	CCLE Cell Line Gene CNV Profiles	1.0	1.33156
STK10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67991
AP3D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65996
Lambert-Eaton myasthenic syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
striatum_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0883
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.28026
benzathine benzylpenicillin-4140	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Neuron projection terminus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.843
CWF19L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06342
Lung squamous cell carcinoma_LUSC_TCGA-NK-A5D1-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
paraventricular nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03786
ATP6V0A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07681
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16187
SLC12A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82785
Perturb_637_KO_SOX4_ERP117895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.5003
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	1.0	null
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.79383
DNAJC25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4598
GSE94814_1_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
blood vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.328262
r6 part of rostral ventromedial reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33415
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.582594
NSC-34 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.541
TGFBR3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85664
axon hillock	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.640145
GSE68925_1_v_0_fasudil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PRKACB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76862
dorsomedial part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.70707
dorsal thalamus_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.15185
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.886801
3-acetamidocoumarin-4426	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE84678,GSE93902_1_v_2_bcl11b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
FAM171A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13654
passive transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
gallbladder	HPA Tissue Protein Expression Profiles	1.0	0.756656
MB21D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65918
Perturb_12997_KO_rs2431697_ERP121303	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.25211
increased thermal nociceptive threshold	MGI Mouse Phenotype Associations 2023	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.31261
SIX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73998
MTF2-20144788-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
arcuate nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.61238
GSKIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36269
PCMTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51827
PHC1	ChEA Transcription Factor Targets	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.01742
hsa-miR-1827	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
GSE210383_0_v_1_trim71_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Myelencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.09
ventrolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26687
colchicine-644	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	0.756656
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
astroglial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.252261
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.577
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.283
ZNF717	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52355
pempidine-2172	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PA-TU-8902	COSMIC Cell Line Gene CNV Profiles	1.0	2.64759
GSE254155_5_v_0_per2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Dalfampridine	DrugBank Drug Targets	1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lobules IV-V, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55641
H3C15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49622
hsa-miR-2278	TargetScan Predicted Conserved microRNA Targets	1.0	0.017945
GSE193354_0_v_1_saraf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lateral ventricle	HPA Tissue Protein Expression Profiles	-1.0	-0.925319
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.893492
Granular lamina of the cochlear nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64002
COLO-829	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A1L0-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE174498,GSE174500_5_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11034
SPI1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180200,GSE180201_5_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LANCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17634
SLFN14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57168
PMC7862469-13238_2020_779_MOESM4_ESM.xlsx-FOXO3-GE_VS_WT-GeneID_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09177
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.351485
Myokymia	DisGeNET Gene-Phenotype Associations	1.0	null
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21024
H3K27me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
red nucleus, magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45949
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
stratum pyramidale of caudal CA3	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.94365
SUPT1	CCLE Cell Line Gene Expression Profiles	1.0	1.45541
hsa-miR-3907	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
NOXO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89008
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
TOP2B-26459242-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BCL2L11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15684
Crus 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25864
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.24052
Status epilepticus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
H1-0	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42474
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intermediate part of r8B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08698
PACSIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76624
LRCH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55599
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Atrial fibrillation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
LCOR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76563
RhoGDIbeta_KD_GDS2864_634_human_MDA-MB-231 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
gastric epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.469211
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_42_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.310059
renal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.18232
Wt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	89.7227
ADAM10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08641
HCT15	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.12581
Primary somatosensory area, lower limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12144
biological_process	GO Biological Process Annotations 2015	1.0	null
neuron part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.721688
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.125618
IgSF CAM signaling	KEGG Pathways 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8083-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AMIFAMPRIDINE PHOSPHATE	DGIdb Drug Targets 2026	1.0	0.13233
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.44823
parathyroid gland	HPA Tissue Protein Expression Profiles	1.0	0.756656
migraine	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.270819
BTB/POZ fold	InterPro Predicted Protein Domain Annotations	1.0	null
E2F6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32315
protein complex	GO Cellular Component Annotations 2015	1.0	null
PDXDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5207
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
hsa-miR-4731-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
KMS-21BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.73839
DPH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94223
recognized	GeneRIF Biological Term Annotations	1.0	null
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04457
spinal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.176213
posterior (ventral) nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08958
SND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65202
layer III of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03422
RNF2-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
r7 part of parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.75372
cerebral arterial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.356709
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.67821
EP300	ENCODE Transcription Factor Targets	1.0	null
GSE148657_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SCL-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
inorganic cation transmembrane transport	GO Biological Process Annotations 2023	1.0	null
BICD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06204
cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.050693
cation channel activity	GO Molecular Function Annotations 2015	1.0	null
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
metal ion transport	GO Biological Process Annotations 2023	1.0	null
CACNG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01472
STRADA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02117
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41794
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11116
Perturb_4456_KD_Mecp2_SRP125116	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.72284
ERBB4:ERBB2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.512
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE245270_2_v_0_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
electric organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.676987
Brain Lower Grade Glioma_LGG_TCGA-DH-5140-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.32045
Lobule III	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4474
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.28824
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26979
valproic acid-5582	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CGNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18736
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.61832
WRAP73	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49276
&alpha;-dendrotoxin	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
CTHRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39933
GNS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51573
Perturb_3442_KO_Mll4_SRP101279	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.22921
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.941109
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHC1-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
Pancreatic islet cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.536
abnormal circulating triglyceride level	MPO Gene-Phenotype Associations	1.0	null
GSE70499_3_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.170299
potassium channel complex	GO Cellular Component Annotations 2025	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2944-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
right atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.29673
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gated channel activity	GO Molecular Function Annotations 2015	1.0	null
APEX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68043
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NDUFB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47722
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.34072
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.40077
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5881-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WP-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Crus 1, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38473
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04517
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Potassium Channels	Reactome Pathways 2024	1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.183025
GSE245270_2_v_3_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K029AX	DepMap CRISPR Gene Dependency	1.0	2.31321
Perturb_10355_KD_SHQ1_SRP154234	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.2928
GSE236502_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lobule III, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.364
ATAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69133
hsa-miR-377	TargetScan Predicted Conserved microRNA Targets	1.0	0.053794
hsa-miR-4292	TargetScan Predicted Conserved microRNA Targets	1.0	0.008128
Smad4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.22
CALHM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11888
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6190_KO_Mecp2_SRP188207	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.30347
SNAP29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05201
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATPAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18833
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182680,GSE182683_0_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
potassium channel activity	GO Molecular Function Annotations 2025	1.0	null
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4763-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
LARP4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69795
F36P	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54351
NOP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43024
PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CMBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41909
DCAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90521
r9 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.46982
cis-golgi network membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.867666
RPP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44798
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-7658-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
PCLAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75791
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Calyx of Held	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.971
TEF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70206
IFT57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11949
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.40805
Spinal cord neuroblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.203
3-acetamidocoumarin-4601	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.880686
Lobules IV-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59688
BT474	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.759492
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EL-01A-12R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dantrolene-2329	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TEX19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19889
AR-35650195-DSRCT-HUMAN-MESENCHYMAL-SARCOMA	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10631_KO_Gss_SRP101373	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.38346
Perturb_635_KO_SOX4_ERP117895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_4147_KO_Bcl11a/Bcl11b_SRP334609	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48379
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3194-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.013856
GSE111660_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
trigeminal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.232317
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8986528-41586_2022_4598_MOESM6_ESM.xlsx-Fig_4h-LAS1L_KD_upreg_AR	Rummagene Transcription Factor Associations 2026	1.0	null
neonatal period electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.07866
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.477
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.5391
cis-golgi network	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.274101
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SERP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82434
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.917951
esophagus	HPA Tissue Protein Expression Profiles	1.0	0.756656
GSE68156_0_v_1_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5494-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4755-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
hsa-miR-581	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
oculomotor nuclear complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.92715
thymus cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.364824
hsa-miR-3175	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
hsa-miR-1285	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Neuron projection membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.658
mRNA_KLF4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Cation channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.135
ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.245046
hsa-miR-4432	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
ventral premammillary nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31591
locus ceruleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.893441
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.938607
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.696172
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CCDC88A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12735
CORL88	CCLE Cell Line Gene CNV Profiles	1.0	1.39954
GSE149880_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.27
ZNF263	ENCODE Transcription Factor Targets	1.0	null
cuneus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34669
inner CP in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.936816
GSE174498,GSE174500_2_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2366
Perturb_9596_KO_Prox1_SRP176286	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.12522
astroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067468
Perturb_14257_KO_Homer1/Homer1b_SRP291224	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.46892
GSE116930,GSE116935_1_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
human immunodeficiency virus infectious disease	GWASdb SNP-Disease Associations	1.0	0.562455
PMC4172779-13048_2014_87_MOESM1_ESM.pdf-21-IRF2_IRF2	Rummagene Transcription Factor Associations 2026	1.0	null
ARL6IP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6275
RCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70057
Lung adenocarcinoma_LUAD_TCGA-44-7670-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7773-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAB13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92351
ISTMES1	CCLE Cell Line Gene Expression Profiles	1.0	1.53619
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.71144
DPRX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58998
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16187
hsa-miR-1226	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
PRDX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39791
delayed rectifier potassium channel activity	GO Molecular Function Annotations 2015	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.463
LS-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SRD5A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02544
ORMDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43218
Renal inner medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.976
GSE222758_0_v_2_clofazimine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Compact myelin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.226
VCPKMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84921
Pulmonary artery smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.691
H3C6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55374
Mat-Ly-Lu cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.051
CSPG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83569
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.48898
hongotoxin-1	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FBXW4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43182
TBP	ENCODE Transcription Factor Targets	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
flower	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.59646
HADH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36372
Perturb_16635_OE_Chmp2b_SRP238748	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.50078
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18148
PGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00628
RPS27L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84338
prostate_4c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.55951
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.81765
abnormal pain threshold	MPO Gene-Phenotype Associations	1.0	null
ABHD17B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77244
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_ID1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.987485
Cerebellar Purkinje cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.512
than	GeneRIF Biological Term Annotations	1.0	null
mesenteric artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.520435
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE96641_5_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NGFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63267
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.889841
KIF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05257
MAPKAPK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6722
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.8572
Axon terminus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.772
intermediate stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36272
all	GWASdb SNP-Phenotype Associations	1.0	0.03003
hsa-miR-4757-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
KRAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40218
UNK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3797
SIGLEC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55886
MITD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84647
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.880591
methylamine	CTD Gene-Chemical Interactions	1.0	null
KATO-III cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.867
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.967312
Lobule III, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54203
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.522995
anterior cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07731
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ESD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8107
PRKCSH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78487
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-BrtoFay_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.362
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pacemaker cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.786883
superficial stratum of r7BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46162
Lung squamous cell carcinoma_LUSC_TCGA-56-7223-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14067_KD_ALKBH5_SRP247777	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.17131
MPV17L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67019
GSE142994_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TE8	CCLE Cell Line Gene Expression Profiles	-1.0	-2.10937
RUNX-20019798-JUKART-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
r4 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36164
root tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.25259
musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044559
HCC2108	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54666
UO31	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.967171
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pyramus (VIII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.91994
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAP1GAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76571
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.834052
r3 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07028
Perturb_4049_KO_Pde1b_SRP260102	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.35547
GSE164757,GSE164759_4_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14974
NCIH1105	CCLE Cell Line Gene Expression Profiles	1.0	1.82345
vestibular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.323874
Perturb_16642_OE_Chmp2b_SRP238748	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.40403
GSE142684_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
r4 part of medial pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31804
r4 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42587
Intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
Condensed nuclear chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.054
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.1
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Refractive error	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.769897
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.111
Perturb_1154_KO_USP29_SRP329795	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.87637
RNF2	ChEA Transcription Factor Targets	1.0	null
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
C-fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.385
liver_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.55951
TRIM36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74561
KNSTRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87021
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04177
PMC12005766-ADVS-12-2413120-s003.xlsx-VENN1-Table_S6_related_to_Figure_S6D_List_of_overlapping_DEGs_with_the_E3_or_DUB_gene_set_from_the_iUUCD_2_0_database_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205163,GSE205164_1_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.469987
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.83601
SOX2-22085726-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_14147_KD_RCOR1_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.76151
H3255	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.880591
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.401
hsa-miR-3975	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Prostate adenocarcinoma_PRAD_TCGA-VP-A87C-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SHP77	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3345
BCB000039-7531	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_6179_KO_Mecp2_SRP188207	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.82621
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
plasma membrane part	GO Cellular Component Annotations 2015	1.0	null
TCEAL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00343
PRMT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04765
substrate-specific transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE79663_2_v_0_tcf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.851465
brain_3c	HPA Tissue Sample Gene Expression Profiles	1.0	1.77591
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6ME-01A-22R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inner SZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0652
Sarcoma_SARC_TCGA-3B-A9HL-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.7223
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27943
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.08943
Lung squamous cell carcinoma_LUSC_TCGA-85-8350-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PYCR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1783
trastuzumab_homo sapiens_gpl570_gse15043	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
pi1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.914
PBX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09958
PEPD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96664
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	1.0	null
atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.522011
WDR90	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54736
HT55	Achilles Cell Line Gene Essentiality Profiles	1.0	1.23026
ACHE_OE_GDS891_241_mouse_Prefrontal cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A59E-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JOSD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17368
potassium channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PMC12176927-125_2025_6424_MOESM1_ESM.pdf-23-FOXG1_FOXG1	Rummagene Transcription Factor Associations 2026	1.0	null
potassium channel complex	GO Cellular Component Annotations 2015	1.0	null
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.63261
8305C	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46355
FOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13935
Brain Lower Grade Glioma_LGG_TCGA-DU-7299-01A-21R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.89634
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
internal granular layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23445
TRIO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90458
posteroventral (inferior) parietal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.55794
496100637_FWM_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.28528
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Unnamed_1_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
HOXA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59491
Dorsomedial nucleus of the hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07948
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.206423
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.993222
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TS-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7581777-41419_2020_3029_MOESM6_ESM.xlsx-MNX1_ChIP-Symbol_MNX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7862469-13238_2020_779_MOESM4_ESM.xlsx-FOXO3-GE_VS_WT-Symbol_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
Tuberomammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18385
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TX-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202284,GSE202289_5_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.80569
brain stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.699035
HSG	BioGPS Cell Line Gene Expression Profiles	1.0	0.993518
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.55928
Myasthenia gravis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
GSE133070_2_v_4_prss1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RIPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.07254
USP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0381
protein oligomerization	GO Biological Process Annotations 2015	1.0	null
Plasma membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.532
SIN3B	ChEA Transcription Factor Targets	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19669
IL6ST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81258
DACT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19977
8MGBA	CCLE Cell Line Gene Expression Profiles	-1.0	-2.04646
hsa-miR-1321	TargetScan Predicted Conserved microRNA Targets	1.0	0.011888
Glossopharyngeal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.781
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RAB26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61188
axon part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.774101
rhombomere 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03055
thyroid	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
Carotid body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.079
ZNF507	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59557
KLHDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13088
RASSF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15223
cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.769855
ERV3-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34765
H3K27me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
epilepsy syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.313189
METTL16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82243
SMS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91787
Episodic ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.136
Type II spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
butamben-2531	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Declive (VI), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.75273
PMC5390115-mmc3.xlsx-DE_Lists_Exp_2-H1-EC2_3-fold_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal lipid level	MPO Gene-Phenotype Associations	1.0	null
SPI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA_NRIP1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.480945
GMPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01986
MAF-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
G3BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33874
cellular potassium ion transport	GO Biological Process Annotations 2015	1.0	null
INMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27823
paranode region of axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.424745
charybdotoxin	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Potassium channel tetramerisation-type BTB domain	InterPro Predicted Protein Domain Annotations	1.0	null
orbit	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.230931
SLC38A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96081
PMC3526425-1471-2164-13-572-S3.xlsx-STAT6-STAT6_STAT6	Rummagene Transcription Factor Associations 2026	1.0	null
procyclidine-2991	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SUZ12-18974828-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
mantle zone of r8BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08612
AKAP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7566
H3K9me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE93674_2_v_3_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
pyramidal cells of rostral CA4	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.30481
Chorea	DisGeNET Gene-Phenotype Associations	1.0	null
single-organism transport	GO Biological Process Annotations 2015	1.0	null
NCIH1930	CCLE Cell Line Gene Expression Profiles	1.0	2.65492
SPATC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44618
Lung squamous cell carcinoma_LUSC_TCGA-21-5786-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OCI-LY-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12561
Episodic Kinesigenic Dyskinesia	DisGeNET Gene-Disease Associations	1.0	null
RABGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66804
SSNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18739
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.84312
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_0_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of localization	GO Biological Process Annotations 2015	1.0	null
Perturb_4388_Mut_IRF8_ERP127120	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.3835
Pontine nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.55
Prestwick-864-2994	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ear	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.139387
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16782
hsa-miR-4685-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.072324
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medulla oblongata	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.123247
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HIC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51433
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2995-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Periglomerular cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.184
NEUROG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44755
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
imcd cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.499223
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.851854
1,3-beta-D-glucan synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.531
protein homooligomerization	GO Biological Process Annotations 2015	1.0	null
mast cell degranulating peptide	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.08346
SOX11-23321250-Z138-A519-JVM2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MSGN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76718
Peripheral motor neuropathy_Sciatic Nerve_GSE1947	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.22396
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Juxtaparanode region of axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.439
KCTD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70334
PSMD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11357
hsa-miR-4793-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
benserazide-641	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
limbic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.67821
Sciatic nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.221
Sternal cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.493354
ZNF235	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43123
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7831-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_3846_KD_CABLES2_SRP166266	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.2333
E2F6	ENCODE Transcription Factor Targets	1.0	null
Perturb_4389_Mut_IRF8_ERP134577	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.44063
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
Potassium channel	InterPro Predicted Protein Domain Annotations	1.0	null
TGBC11TKB	COSMIC Cell Line Gene Mutation Profiles	1.0	null
superficial stratum of r3BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18617
PPP4R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99914
trimipramine-3342	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
ARGFX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73089
mantle zone of r9BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10196
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.534
dorsolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.59144
Lung squamous cell carcinoma_LUSC_TCGA-22-5481-01A-31R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNF2-18974828-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_6189_Mut_Mecp2_SRP188207	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.48378
RBPJ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4746
STRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3869
hsa-miR-1910	TargetScan Predicted Conserved microRNA Targets	1.0	0.092495
cortex of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52612
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
plasma membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Prostate adenocarcinoma_PRAD_TCGA-HC-7081-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE173810_0_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Limbic encephalitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.119
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.01326
PTPRG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45267
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40719
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.17724
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.57971
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
embryonic kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.528719
hsa-miR-4660	TargetScan Predicted Conserved microRNA Targets	1.0	0.111118
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU16	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49047
hsa-miR-2114	TargetScan Predicted Conserved microRNA Targets	1.0	0.020071
RT112	Achilles Cell Line Gene Essentiality Profiles	1.0	1.18846
bounding membrane of organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.059092
MDA-MB-453	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cell projection part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.689451
voltage-gated monoatomic cation channel activity	GO Molecular Function Annotations 2025	1.0	null
Small intestine cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.526
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAGLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78441
hsa-miR-324-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
potassium	GeneRIF Biological Term Annotations	1.0	null
pyramidal neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.338914
MYC_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IGROV1	BioGPS Cell Line Gene Expression Profiles	1.0	1.04267
REH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE221577_3_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.184424
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.944995
GSE213632_4_v_5_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Crus 2, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27627
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00416
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4104
TP73	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.22411
ELF1	ENCODE Transcription Factor Targets	1.0	null
PPP1R2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.663
voltagegated	GeneRIF Biological Term Annotations	1.0	null
BRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37721
ORAI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40333
ketotifen-3200	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE239688_2_v_5_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MARCHF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91765
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21238
NME6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90787
GSE212312_1_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
SKMEL31	CCLE Cell Line Gene CNV Profiles	1.0	1.6997
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.96419
Lung adenocarcinoma_LUAD_TCGA-MP-A4TA-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF250	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75837
RCOR1	ENCODE Transcription Factor Targets	1.0	null
HELA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EED-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE176008_0_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SEC61A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63642
axon terminus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.646574
Chemoreceptor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.052
Schwann cell microvillus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.942
PER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74954
NUTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23342
LCLC-97TM1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
AEBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82601
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.904171
RNPEPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.587
transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2955-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
D425	DepMap CRISPR Gene Dependency	1.0	2.30729
DDX3X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86359
SIN3B-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Uvula (IX), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4793
TC-71	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.58493
GSE152432_9_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
rostral ventrolateral reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26515
PMC6928094-395_2019_765_MOESM7_ESM.xls-DEGs_AR7_vs_Pre-patterned-List_of_differentially_expressed_genes_in_AR7_vs_Pre-patterned_cells_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
PARL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64439
C1orf109	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20626
hsa-miR-3185	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
OSGEPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07692
astroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.242363
lateral habenular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.90145
LUC7L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39472
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32214
PSMG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.1112
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17738
hippocampus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.671285
PMC8755441-mmc3.xlsx-IRF7-Up-SUZ12_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.582594
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IFI30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17322
intermediate stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74136
CD3epsilon deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
DU145	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.873044
EED	ChEA Transcription Factor Targets	1.0	null
GSE226584,GSE226589_1_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Neuronal System	Reactome Pathways 2014	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
layer 1 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40561
GSE145915_5_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
previously	GeneRIF Biological Term Annotations	1.0	null
RFX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29898
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MT-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPLP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65557
GSE165647_2_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LHFPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10727
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.96633
channel	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Simple lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4063
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.98265
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.470005
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04533
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.17791
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A871-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6672
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.287803
hsa-miR-3163	TargetScan Predicted Conserved microRNA Targets	1.0	0.004732
monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.207245
GSE195513_0_v_3_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARFRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17005
endoplasmic reticulum	LOCATE Curated Protein Localization Annotations	1.0	null
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.38319
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.83601
STX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38742
PBX3	ENCODE Transcription Factor Targets	1.0	null
CARD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75335
NUCB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37619
protein complex assembly	GO Biological Process Annotations 2015	1.0	null
venom gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.420194
DMPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19993
GSE210101,GSE210114_8_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
PDK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48878
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
mammarygland.lact.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.22694
HMGN3	ENCODE Transcription Factor Targets	1.0	null
vascular bundle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.120791
C12orf76	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19347
TMEM74B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7395
Perturb_9823_KD_TAL1_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.68158
IFT172	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78022
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CNDP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02148
H3K9me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_16636_OE_Chmp2b_SRP238748	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.93899
MN-60	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.920731
EI24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66064
non-neuronal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.377621
HCC2279	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57986
hsa-miR-920	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.521223
BSX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40982
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.20137
EZH2	ENCODE Transcription Factor Targets	1.0	null
O cell_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
MTA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.68005
r6 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.90727
BE2-M17	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RHPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76349
outer CP in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.88992
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SENP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76378
renal distal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.188383
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE173873_1_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
small_intestine	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.880156
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHARYBDOTOXIN	DGIdb Drug Targets 2026	1.0	1.05864
HOXA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.886
Lung squamous cell carcinoma_LUSC_TCGA-37-5819-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MET_knockout_264_GSE8747	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.65585
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATP5ME	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77994
SRSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4571
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.155
intracranial arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.403064
H3K9me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_ASCL1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BABAM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23655
GSE198165,GSE198166_0_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
globus pallidus, internal segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0864
GSE180525,GSE180528_1_v_3_tbx3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77752
Voltage gated Potassium channels	Reactome Pathways 2024	1.0	null
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIKFYVE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18713
plasma membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
oligodendroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.327896
germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.843706
hsa-miR-4327	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
MRPL58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70361
GSE181513_0_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
Myelin sheath	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.432
PMC11917426-ab-24-0547-Supplementary-Table-1.pdf-2-HNF4G_HNF4G	Rummagene Transcription Factor Associations 2026	1.0	null
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PDE6G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08147
ventrolateral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68135
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NO11	DepMap CRISPR Gene Dependency	1.0	3.2208
CLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15946
gastric cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088689
OPTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47038
Integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12107_KD_CCND1_SRP244245	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.95865
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
DCAF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46887
abnormal touch/ nociception	MPO Gene-Phenotype Associations	1.0	null
VSX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32345
hsa-miR-491-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
CD81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2023
PCID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99115
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.429
Sarcoma_SARC_TCGA-DX-A3UB-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
heart_6b	HPA Tissue Sample Gene Expression Profiles	1.0	0.922334
potassium ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
hsa-miR-671-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YW-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE215351,GSE215794_7_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Detrusor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.574
butacaine-2728	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE210580_0_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SIRT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73302
LRRC58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91412
POGLUT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26761
SOX11	ChEA Transcription Factor Targets	1.0	null
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02663
Retrochiasmatic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11705
hsa-miR-448	TargetScan Predicted Conserved microRNA Targets	1.0	0.017945
MISP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79202
Lobule II, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44064
HEC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SUP-B8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
adrenal_4c	HPA Tissue Sample Gene Expression Profiles	1.0	1.07431
CSB-26484114-CHIP-SEQ-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Neuromuscular junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.332
ZFX_KO_GDS2718_150_mouse_embryonic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
potassium channel complex	GO Cellular Component Annotations 2023	1.0	null
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.886756
haloperidol_mus musculus_gpl339_gds2531	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC4063835-epi-9-760-s02.xls-MI_vs_NU-SYMBOL_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
oocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.012
KYSE-140	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE152055_0_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar white matter	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01841
Folium-tuber vermis (VII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78238
inferior olivary complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.04633
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Central lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37456
CCDC80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06251
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.56148
tonsil_8b1	HPA Tissue Sample Gene Expression Profiles	1.0	0.84725
Ion channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.94424
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SH3BP5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08912
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.88398
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.22326
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.54289
single-organism localization	GO Biological Process Annotations 2015	1.0	null
SNRK_overexpression_127_GSE30185	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.05545
inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.986764
stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.090314
RGM-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.402
PML	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47101
ALVA31	BioGPS Cell Line Gene Expression Profiles	1.0	0.833721
Perturb_4048_KO_Pde10a_SRP260102	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.63828
MKNK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89495
primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.72625
potassium ion transport	GO Biological Process Annotations 2015	1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNF213	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95653
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08086
pheniramine-4130	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE138019_4_v_6_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCK-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DALFAMPRIDINE	DGIdb Drug Targets 2026	1.0	0.1203
L3MBTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7246
GSE228894_0_v_2_rnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Episodic Ataxia	DisGeNET Gene-Disease Associations	1.0	null
CCDC93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.72687
C19orf81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22936
TIGD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01599
posterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.232
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052658
Declive (VI), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85755
ZNF808	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05247
SOX2-19030024-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
IA-LM	COSMIC Cell Line Gene CNV Profiles	1.0	2.64759
primary auditory cortex (core)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.875362
CSNK2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46184
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prestwick-692-4599	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
vestibular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.173717
TTC30A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27043
SNCA_KO_GDS4153_444_mouse_Cerebellum - 21 month	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
primary auditory cortex (core)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.50197
SIK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52137
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
broader	GeneRIF Biological Term Annotations	1.0	null
UBE2J1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24784
RASSF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01859
hsa-miR-4673	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.416521
heart_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.31146
RBM46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64875
LRP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19588
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DTX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32094
RTL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91968
GSE238018_3_v_2_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Voltage-gated potassium channel	InterPro Predicted Protein Domain Annotations	1.0	null
Perturb_6188_KO_Mecp2_SRP188207	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.43938
RMUGS	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.10018
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.448
superficial stratum of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41187
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.61342
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041241
Anteroventral periventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76854
Orthogonal array	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.725
Cochlear nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2343
SPOUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38274
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04457
KYSE-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Twist2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.8894
SPSB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53727
A673	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.73422
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EW-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.25424
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4899-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mm96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.766
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.03016
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44963
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TI-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4293	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
MFAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01212
superficial stratum of r6BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09515
Primary T cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.07176
CNTRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91419
NUDT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68763
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDAMB453	Achilles Cell Line Gene Essentiality Profiles	1.0	1.16506
Crus 1, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37931
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19B-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
acemetacin-5460	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CBP-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.187646
placenta_3a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.843099
hsa-miR-622	TargetScan Predicted Conserved microRNA Targets	1.0	0.115091
Lung squamous cell carcinoma_LUSC_TCGA-43-3394-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.837025
layer V of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.65336
periventricular stratum of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01751
COV504	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.31046
DACH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10298
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17649
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.890269
ALDH16A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82215
SP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.53628
KIAA1586	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68564
intermediate stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31108
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.879629
MCM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49789
r9 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21072
membrane	LOCATE Curated Protein Localization Annotations	1.0	null
GSE210870_0_v_1_snai1_human	RummaGEO Gene Perturbation Signatures	1.0	null
QRSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34554
Giant axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.041
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4159-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NAP1L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04074
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05245
stratum oriens of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21072
medium spiny neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.287447
Modiolus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.298
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE84678,GSE93902_3_v_2_bcl11b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
axon initial segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.759524
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03693
Autoimmune disease of skin and connective tissue	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
GSE223008_9_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mantle zone of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21277
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RECQL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52703
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.49603
TM31	CCLE Cell Line Gene Expression Profiles	-1.0	-2.54835
shoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.078254
ZNF512B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60523
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
LATS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05902
ARHGEF10L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9888
ARL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79443
EIF2AK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80688
GSE149880_2_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
zfpm2_19411579_heart_lof_mouse_gpl1261_gds3659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.029938
hsa-miR-133b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
potassium channel activity	GO Molecular Function Annotations 2023	1.0	null
seed	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061518
Encephalitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.499
APOD_OE_GDS3913_489_mouse_Cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
RUNX2	JASPAR Predicted Transcription Factor Targets	1.0	null
SRRD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.22713
TOMM34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7393
GSE238018_1_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE105169,GSE105175_0_v_1_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10344
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.5863
pituitary	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.64726
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRMT10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84624
WDCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45193
HS683	DepMap CRISPR Gene Dependency	1.0	2.05333
ion transport	GO Biological Process Annotations 2015	1.0	null
UBF1/2-26484160-CHIP-SEQ-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4722-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE229468,GSE229471_2_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.58684
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.88285
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JPH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26684
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41886
embryonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.324605
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BIRC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.69657
Perturb_3851_KD_SCN5A_SRP260805	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_16651_KD_Fus_SRP179634	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.03196
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.887037
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-320e	TargetScan Predicted Conserved microRNA Targets	1.0	0.065994
hsa-miR-4776-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
MEF2A	ENCODE Transcription Factor Targets	1.0	null
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4653-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.23348
NCCRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95105
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.933094
KM12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EZH2-27304074-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.90657
potassium ion transport	GO Biological Process Annotations 2023	1.0	null
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
AK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48473
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.39258
hsa-miR-766	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.03262
TBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.747
TMTC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68082
hsa-miR-1273e	TargetScan Predicted Conserved microRNA Targets	1.0	0.050854
Uterine Carcinosarcoma_UCS_TCGA-ND-A4WF-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2236
CLASRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93361
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01545
SLC22A17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64929
mRNA_MYC_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE180951_2_v_3_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF347	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93872
MYCN-27167114-CHIP-SEQ-NEUROBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FASTKD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60978
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
levodopa-4394	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE180200,GSE180201_3_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
adrenal gland	HPA Tissue Gene Expression Profiles	1.0	1.0453
SOX2	ChEA Transcription Factor Targets	1.0	null
GSE233679_5_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-6560-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Parallel fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.796
Perturb_13110_KO_Foxm1_SRP194062	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.69743
TRIM28	ChEA Transcription Factor Targets	1.0	null
HSC-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
parafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.971821
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EBNA1-20929547-CHIP-SEQ-RAJI-CELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44639
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5081-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.579216
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.41235
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70N-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skin	HPA Tissue Protein Expression Profiles	-1.0	-1.08941
MYSM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15671
GCNT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0135
fatty-acyl-CoA synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.502
SERBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70989
GSE176008_4_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_4063_KO_Tcf20_SRP260102	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.74482
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.266757
SCA1_Knock-in_GDS3544_562_mouse_Cerebellum - 12 Weeks	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ketorolac-3110	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IBTK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.38927
hsa-miR-545	TargetScan Predicted Conserved microRNA Targets	1.0	0.047969
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A6RX-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Oliva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.899
GSE211983_1_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
outer CP in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.943285
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.43744
transporter activity	GO Molecular Function Annotations 2015	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Toxic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
hindbrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.55607
OTUD7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8295
HUCCT1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67564
PBX1-22567123-OVCAR3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SLC38A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3514
glia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.407832
ChIP_RNF2_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
ZNF888	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85427
Potassium channel, voltage dependent, Kv1	InterPro Predicted Protein Domain Annotations	1.0	null
RASA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81222
Purkinje cell layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15137
vincamine-2327	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF708	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64904
KLF16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56818
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NKX3-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58826
JHUEM3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.7014
NCIH2141	CCLE Cell Line Gene Expression Profiles	1.0	1.98625
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.98164
transmembrane transporter complex	GO Cellular Component Annotations 2015	1.0	null
FAM3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59431
Paroxysmal Kinesigenic Choreoathetosis	DisGeNET Gene-Disease Associations	1.0	null
metal ion transport	GO Biological Process Annotations 2025	1.0	null
Physical activity (moderate intensity activity duration)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.769897
NDUFV2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73625
FAM53C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1434
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
GSE129370_0_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
ENOPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72579
LI7	CCLE Cell Line Gene CNV Profiles	-1.0	-2.43675
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Muscle Spasticity	DisGeNET Gene-Phenotype Associations	1.0	null
core of P-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.32485
PAX5	ENCODE Transcription Factor Targets	1.0	null
GSE128634,GSE128636_4_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
r10 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.236
potassium ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Neuropil	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.067
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5022-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-0.950738
MARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66308
MPZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65865
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.911197
Medial preoptic nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26048
VPS33A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31214
PSEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42544
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11187
Albumen gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.632
sensor	GeneRIF Biological Term Annotations	1.0	null
GSE142684_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4728-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.03694
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6792-01A-21R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_Jurkat_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
GSE144484_0_v_1_mllt6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.02014
MINK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61536
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE70935_3_v_4_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PRR35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4966
NUDT18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65701
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.73064
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.879501
MRPL21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32509
increased thermal nociceptive threshold	MPO Gene-Phenotype Associations	1.0	null
hsa-miR-3690	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-Netherlands-602-2009(H1N1)_7Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.57875
Nematocyst	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.696
Crus 2, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24963
periventricular nucleus of hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.744627
ZNF266	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70568
intermediate part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10324
voltage-gated potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.459
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.949428
IL18BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2053
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.66695
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	136.519
inorganic cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
abnormal blood homeostasis	MPO Gene-Phenotype Associations	1.0	null
HOXB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94591
Brain Lower Grade Glioma_LGG_TCGA-DU-7007-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-MEL-30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
caudal subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.889806
CHO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.289
SCLC21H	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34313
GSE100464,GSE100465_0_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CREB1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
plant form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060191
striatum_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.926328
etofylline-2093	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Glomerular layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.155
Brain Lower Grade Glioma_LGG_TCGA-DB-A75O-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CLDN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79478
anteroventral periventricular preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.41266
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WV-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LMSU	CCLE Cell Line Gene CNV Profiles	1.0	1.93619
gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043468
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A6HP-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SU-DHL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38015
inorganic cation transmembrane transport	GO Biological Process Annotations 2025	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
NPM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88296
Perturb_13190_KO_Wnt5a_SRP346437	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.76682
eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070222
LDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27646
r6 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63328
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06125
SNU1105	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.21355
ZSCAN26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10153
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.58228
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CML-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF713	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39699
ME2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83721
HDAC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86667
TBX15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91655
H3K27me3_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARRDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.16112
ETFRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8002
PRXL2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39772
TRIB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92384
peripheral ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.241132
UBXN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17196
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4889-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Venom duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.908
POLR2A	ENCODE Transcription Factor Targets	1.0	null
thyroid_5c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.892436
KLF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.3563
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
mantle zone of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42819
Ltk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.467
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.93048
GSE88819_3_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitral cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.183
GSE68156_3_v_4_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.372
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATM_Deficiency_GDS1544_769_mouse_Lymph nodes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.824959
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00333
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	2.80979
maprotiline-3236	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-1301	TargetScan Predicted Conserved microRNA Targets	1.0	0.031759
shoot tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.402523
ventrolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03539
TC71	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38872
ZNF143	ENCODE Transcription Factor Targets	1.0	null
GSE210580_5_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.996215
abnormal behavior	MPO Gene-Phenotype Associations	1.0	null
ATRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02826
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09245
ANKRD13D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33042
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE119345_2_v_4_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GUANIDINE HYDROCHLORIDE	DGIdb Drug Targets 2026	1.0	0.13233
CILP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68263
ChIP_EZH2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Perturb_4122_OE_Mecp2_SRP172565	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.78013
arterial smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.683919
AP1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62321
lateral part of MM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3834
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.54692
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.368
SOX11-23321250-Z138-A519-JVM2-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Neuronal System	Reactome Pathways 2024	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE137702_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
Uterine cervix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.24
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.3979
ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Encephalomyelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.335
SK-UT-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03233
dentate (lateral) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.849154
GSE182680,GSE182683_0_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FAM135A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5834
JVE015	DepMap CRISPR Gene Dependency	1.0	3.7848
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.915064
ZNF484	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49019
GSE153137,GSE153140_2_v_0_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
precuneus, right, inferior lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03341
pronephros	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.312595
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H64	COSMIC Cell Line Gene CNV Profiles	1.0	2.64759
dentatorubral-pallidoluysian atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.728547
CORL47	CCLE Cell Line Gene Expression Profiles	1.0	1.48416
kato-iii cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.350001
hsa-miR-3174	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
hsa-miR-760	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
cerebellar cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15527
artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.062726
496100575_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15551
COL6A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87102
DTX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6097
BBX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43136
Perturb_6177_KO_Bmal1_ERP113681	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.13404
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.36641
Olig2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.7805
PRKD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3264
GSE133213_6_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inner ear	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.15868
mantle zone of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43765
SKNFI	CCLE Cell Line Gene Expression Profiles	1.0	2.29185
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.920731
superficial stratum of r4BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31733
primary motor cortex (area M1, area 4)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.3398
UXT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36213
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073639
Ventromedial hypothalamic nucleus, dorsomedial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.51247
cell-cell signaling	GO Biological Process Annotations 2015	1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19301
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GZ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.13414
Adrenocortical carcinoma_ACC_TCGA-OU-A5PI-01A-12R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.959697
NIPBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70421
Perturb_11939_KD_SPI1_ERP119419	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.28804
neuroacanthocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.01132
KPNYS	DepMap CRISPR Gene Dependency	1.0	2.90628
PPIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25457
Simple lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45865
Gastric epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.815
Brain Lower Grade Glioma_LGG_TCGA-HT-7478-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary motor area, Layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08654
TrigeminalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.66885
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.920731
H3K4me1_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
synaptic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.123582
NAMALWA	CCLE Cell Line Gene Expression Profiles	-1.0	-1.4797
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.907528
periventricular stratum of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36164
Spinal root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.587
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.950181
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF675	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60519
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.11392
Fetalbrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.939561
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16187
mp90	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.566
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040895
GSTM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.4829
PPP2R3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88784
TNFAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92997
Copula pyramidis, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08914
Outer mantle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.542
E2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.927
WDR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11012
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.940134
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEC50B	CCLE Cell Line Gene CNV Profiles	-1.0	-1.74593
hsa-miR-3187-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.65143
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_EED_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
cochlear ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.226926
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NACC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56753
ARFGEF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87184
SEPTIN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37088
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
diencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.115892
Simple lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5082
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.86745
GSE113106_2_v_1_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WM983B	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
thyroid_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.55951
GSE116930,GSE116935_3_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-212	TargetScan Predicted Conserved microRNA Targets	1.0	0.059817
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cell communication	GO Biological Process Annotations 2015	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CCDC24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4798
ventrolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.45596
SP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.838828
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.841997
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ion channel activity	GO Molecular Function Annotations 2015	1.0	null
GSE111660_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OS-01A-12R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cerebellar cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34031
Perturb_17917_KO_Shank2_SRP314506	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.43605
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30383
hsa-miR-4253	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
GSE223008_7_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PCDH18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03895
PPAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45924
Diabetic neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
NCIH1703	CCLE Cell Line Gene CNV Profiles	1.0	1.67094
Mitral cell layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.25
NCIH841	CCLE Cell Line Gene Expression Profiles	1.0	1.57625
connecting tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.394197
exocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.079624
hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.137261
KASUMI6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64541
PANC-03-27	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MESD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75089
MOSMO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86251
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38078
SMARCA4	ChEA Transcription Factor Targets	1.0	null
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
prostate_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.55951
CDX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37921
GSE182680,GSE182683_10_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.884036
HSP90AB1	Pathway Commons Protein-Protein Interactions	1.0	null
KBTBD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23411
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0429
OTX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51177
mat-ly-lu cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.585224
UXS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47327
mantle zone of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45039
Paramedian lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22071
GSE210580_0_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
voltage-gated potassium channel complex	GO Cellular Component Annotations 2015	1.0	null
LIMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66711
Glomus cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.094
embryoday6.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.963186
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
transport	GO Biological Process Annotations 2015	1.0	null
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.449501
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.06471
OGDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35072
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05678
CEBPA-26348894-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZBED3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26123
IGDCC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41634
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE237040_0_v_3_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.844895
Potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.366
cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.055502
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
ethisterone-2366	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CALU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61361
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLDN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50966
GSE70499_3_v_6_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MHHCALL4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57942
denatonium benzoate-6502	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85796
Perturb_848_KD_Arnt2_SRP166456	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.42275
core of T-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.37096
TMEM69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57438
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
Perturb_1161_KD_E2APBX1_SRP115954	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.2106
DND-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TSPYL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57952
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.5287
benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040836
medial part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09941
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HOXB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5948
mRNA_MSC_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
PMC11682006-13105_2024_1045_MOESM1_ESM.pdf-58-SOX30_SOX30	Rummagene Transcription Factor Associations 2026	1.0	null
benign neonatal seizures	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.71681
SRY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.31332
Satellite glial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.925
abnormal homeostasis	MPO Gene-Phenotype Associations	1.0	null
H3K4me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
cerebellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.580417
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y8-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.56
C1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1182
NCIH1703	CCLE Cell Line Gene Expression Profiles	1.0	2.27482
Adrenocortical carcinoma_ACC_TCGA-OR-A5J5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58051
GSE157555,GSE157556_5_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RUNDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61041
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.879882
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7398-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12971_KD_GATA3_SRP372594	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.51484
LYAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0653
ChIP_SOX17_20123909	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Plasma membrane protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.98164
KMS21BM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68942
Cochlea	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.274
hsa-miR-499-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.047969
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.425514
HS2ST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69716
ZNF577	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27988
LOVO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MYORG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74921
CLDN18_KO_GDS4961_28_mouse_whole lung tissue	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
SYCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13939
RBCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01482
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-153	TargetScan Predicted Conserved microRNA Targets	1.0	0.011888
hsa-miR-3173-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
NEUROD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4669
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.6302
TNFRSF10D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96822
PRIMPOL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07527
cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
HCFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.14239
SEMA3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90969
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16764
Spinal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.188
dorsolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10407
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.955079
CLDN18_KO_GSE48443_44_mouse_lung	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
hsa-miR-133a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Copula pyramidis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05207
HOXB7-26014856-BT474-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MEWO	CCLE Cell Line Gene CNV Profiles	-1.0	-1.65187
ALAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01487
MELHO	DepMap CRISPR Gene Dependency	1.0	3.06453
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06788
calyx of held	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.42036
Sodium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.335
PPP1R16A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64018
PMC8202205-NIHMS1706275-supplement-Table_S3.xlsx-Day_4_GATA6-dependent_genes-GATA6-dependent_mRNA_expression_Day_4_Definitive_Endoderm_FDR_0_05_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
lung	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.937659
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.09208
mRNA_FEM1B_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
regulation of transmembrane transport	GO Biological Process Annotations 2015	1.0	null
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
posteroventral (inferior) parietal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.36828
RP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1202
GSE126345_2_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EPS8L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03443
NUDT15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91859
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060848
C11orf96	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17346
ZNF441	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54866
episupraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51959
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20157
sirolimus-2702	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BECKER	CCLE Cell Line Gene Expression Profiles	-1.0	-1.62128
U87	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.910631
GSE68156_0_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_12093_KO_Malat1_SRP132307	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.31901
GSE120612_4_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Internode	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.872
CHD1	ENCODE Transcription Factor Targets	1.0	null
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4992
hsa-miR-133b	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
THP1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.89214
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.135
STOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64437
EBF1	ENCODE Transcription Factor Targets	1.0	null
dorsal thalamus_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.878491
hsa-miR-1972	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.21
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	96.0144
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.0806
BEST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97602
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38759
C19orf53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50049
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.083563
Hemiplegia	DisGeNET Gene-Disease Associations	1.0	null
HELA	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.996685
LS1034	CCLE Cell Line Gene CNV Profiles	1.0	2.06981
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9699
KMT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96041
GSE195559_6_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null