association	dataset	threshold value	standardized value
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.40991
RHCE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0048071
BRD-K33860558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01601
GTEX-QDVN-2326-SM-2S1PF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901408
GMPPB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00622892
BEX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21174
MDAMB157	CCLE Cell Line Gene Expression Profiles	1.0	1.74539
SIRPG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00746075
Sarcoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.343
BRD-K03554945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17198
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63205
GTEX-R55G-1126-SM-48FDG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01107
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K09663164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43593
PDE1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00520676
EIF2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02647
plasma membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GSE256181_1_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XBEC-0008-SM-4AT3X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986177
PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_UPREGULATED_IN_ERGhigh_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
MOCS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30584
GTEX-XBEC-0326-SM-4AT4M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861548
TMEM98	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24459
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
TFAP4::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.1024
heart	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ZNF180	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87332
MEF2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21937
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
GSE146074_9_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U4B1-1926-SM-3DB9E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00919
AOX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00388357
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2552
GTEX-S4P3-0926-SM-4AD54	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49749
apical part of cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.15771
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922836
BRD-K69932463_AZD-8055_HME1_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
thyrotoxicosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.613574
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.57808
GTEX-Q2AH-0726-SM-2I3EA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852505
BRD-K57517066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81361
PMC7892341-41388_2020_1606_MOESM3_ESM.xlsx-Tables_S4-RNA-seq_LetR_only_AIB1_differentially_expressed_genes_not_present_in_MCF7_cells_Related_to_Figure_1_NCOA3	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-520g	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
bronchus	HPA Tissue Protein Expression Profiles	1.0	1.80738
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.914832
GSE167956_4_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NEUROD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00650745
PRKAG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18095
RNF169	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56373
immune system cancer	GWASdb SNP-Disease Associations	1.0	0.250475
PKN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520176
BRD-K21296995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29106
nicergoline-6251	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K71871382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63645
BRD-K77890526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05359
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K43389698_BMS-387032_BT20_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K96101240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39893
PMC5055179-CAM4-5-2522-s008.xlsx-S1-Supplementary_Table_S1_Properties_of_genes_upregulated_by_MBD-TET1-CDwt_TET1	Rummagene Transcription Factor Associations 2026	1.0	null
RH-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-T5JC-0326-SM-4DM5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80966
Perturb_9488_KD_Appbp2_SRP359770	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	15.5983
USB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14415
LHX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44491
GSE70935_3_v_4_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Vascular smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.028
BRD-K13888422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12335
BRD-K34277236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25461
BRD-K16682693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00446
GTEX-X62O-1626-SM-46MW9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71689
periventricular stratum of r8Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10409
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6532
BRD-K01436366_XMD-1150_HS578T_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE226285_3_v_0_nr0b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3177
BRD-K20271744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07054
Cerebral lobe	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Primary somatosensory area, barrel field, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24735
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.067225
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7235-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K64742599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24172
TPD52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01025
hsa-miR-2467-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
BRD-K17953061_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K62229896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08967
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A6RX-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPP2R5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42291
juxtamembrane	GeneRIF Biological Term Annotations	1.0	null
GTEX-RN64-1626-SM-48FD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05307
GSE146982_7_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Long QT syndrome 14	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.582
KDM1A_KD_GDS5055_457_mouse_adipose tissue	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.572018
BRD-K07484899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08418
BRD-K77320034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10513
AP1G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55878
BRD-K08806664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.25061
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
Crizotinib (hydrochloride)_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0265361
NENF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83874
LIPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54963
GSE197686,GSE197688_2_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE181517_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K04195898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15713
IL27RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00446805
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.417
18425577-TableS3a	GeneSigDB Published Gene Signatures	1.0	null
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852163
GSE179002_2_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PTPRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54573
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-2.06114
Perturb_15632_KO_Sirt1_SRP051387	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.25884
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Digitoxin_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0205024
BRD-K52383401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01681
GTEX-WI4N-1126-SM-3LK7Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21934
BRD-K70511574_sunitinib_HCC515_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF561	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44118
MEF2A-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K05857732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23847
voltage-gated potassium channel activity	GO Molecular Function Annotations 2025	1.0	null
Atazanavir (sulfate)_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0251522
single-organism localization	GO Biological Process Annotations 2015	1.0	null
LN382	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.58689
doxycycline_mus musculus_gpl2872_gse33875	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TNFRSF13C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39368
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.63706
Perturb_16432_OE_E2f4_SRP327850	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-14.1183
BTG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31316
OVCA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00678804
Mean spheric corpuscular volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.40969
SCL-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.28015
CD1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.007254
Lung adenocarcinoma_LUAD_TCGA-44-2655-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
muscle	GeneRIF Biological Term Annotations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4870-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MARCKS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27275
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RNF32	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564774
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.55603
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
ACCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44391
DNAJC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12683
ZER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41512
layer 6 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04825
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DYRK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00630836
BRD-K11663430_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TXNDC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78441
GSE162892_3_v_5_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13752
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
familial atrial fibrillation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.619834
GTEX-WOFM-1726-SM-3MJFA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42082
H3C3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28523
Liver Diseases	CTD Gene-Disease Associations	1.0	1.23296
BRD-K16485616_mocetinostat_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IL18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00691488
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839449
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
L428	CCLE Cell Line Gene CNV Profiles	1.0	1.37369
vascular tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.122646
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962704
hsa-miR-4498	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
DPY19L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22615
BRD-A31159102_Fluoxetine hydrochloride_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FBXW7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00642713
CTSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13223
GTEX-WYVS-2526-SM-3NMAT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838929
TPBG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59531
BRD-K65228230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64256
Perturb_13137_KO_Ing1_SRP149486	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-13.2658
NRN1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66505
r9 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34347
hsa-miR-4666-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.226173
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54463500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.7559
phenyl-aminosalicylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18414
abnormality of the pharynx	GWASdb SNP-Phenotype Associations	1.0	0.969142
JMJD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43338
hsa-miR-381	TargetScan Predicted Conserved microRNA Targets	1.0	0.23348
GTEX-R55F-1426-SM-2TF53	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892741
BRD-K50000283_PHA-767491_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SDC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00695126
GNGT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00462987
SCN4B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00576198
BRD-K75410936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05213
primary motor cortex (area M1, area 4)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.53307
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MIAPACA2	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.00664
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927103
GSE226249_5_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
r7 part of parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28689
GTEX-RVPU-1526-SM-47JXQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869523
VARS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00354011
cardiac conduction	GO Biological Process Annotations 2025	1.0	null
MEF2A	ChEA Transcription Factor Targets	1.0	null
BRD-K22134346_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JHOS4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50525
BRD-K76450502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29828
GTEX-XXEK-1726-SM-4BRVB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83778
GTEX-RU1J-0826-SM-46MUU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04019
TEFM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34775
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K21680192_mitoxantrone_PC3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SOCS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00588915
BRD-K05392698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40039
BRD-K21672174_Ro 28-1675 ?_A673_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
acquired metabolic disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.274608
SLC6A13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00581119
Systolic blood pressure x smoking status (current vs non-current) interaction (1df test)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.539794
CACO2	CCLE Cell Line Gene CNV Profiles	1.0	2.05861
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3C8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00759453
BRD-K81651477_Parthenolide_HA1E_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DOT1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55636
SLC24A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41991
hsa-miR-520h	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
kv42	GeneRIF Biological Term Annotations	1.0	null
RNF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07091
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.751966
SLC38A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3514
BRD-K04546974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25547
BRD-K07602825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44689
BRD-K69038251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59822
Primary somatosensory area, upper limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06319
vitamin c_homo sapiens_gpl570_gds3635	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Body Height	DisGeNET Gene-Phenotype Associations	1.0	null
tsA-201 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.223
GTEX-U8XE-1026-SM-4E3HM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998869
SOX9-24532713-HFSC-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MOSMO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86251
DIAPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22831
NTHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19508
GTEX-WFON-1226-SM-3TW8F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944506
AMHR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00533692
BRD-K62554329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39652
effect	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-766	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
BRD-K91593159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29776
BRD-K69960043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17494
LY2090314_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0124889
liver	GTEx Tissue Gene Expression Profiles	-1.0	-0.857915
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4811
BRD-K84593579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33406
responsible	GeneRIF Biological Term Annotations	1.0	null
regulation of ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
BRD-K20000640_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE178255_3_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6344081-elife-40364-supp5.xlsx-PLZF_peaks_H3K27Ac_gain-Unnamed_10_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28463
potassium channel inhibitor activity	GO Molecular Function Annotations 2025	1.0	null
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.8077
GSE214931_4_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r3 part of magnocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06889
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02201
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23843
hsa-miR-3148	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE146612_1_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K58025976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	6.16473
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04276
Digenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.761
p3 portion of the substantia nigra pars reticulata	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13816
GSE168797_1_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8213
SEMA6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46393
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873876
GSE157777_2_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Olfactory tubercle, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0361
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K48056188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17987
paclitaxel_homo sapiens_gpl570_gse19136	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.442
CRELD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15538
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.63432
BRD-K13071687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17167
CRCGN017_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9654
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K96768352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04536
pallidal part of olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07376
basal part of terminal hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09437
ANTXR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0064546
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Primary somatosensory area, barrel field, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02257
Dlx5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.0881
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.778
ZNF16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11212
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44593
SPRED2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00383194
SULT1C4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02975
BRD-K64800655_PHA-793887_A549_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE74490_0_v_1_triptolide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3N_Peaks_YAP1FAM118B_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
MTSS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98305
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16239
LN215	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.45506
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.81538
BRD-K87909389_alvocidib_MDAMB231_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K42918627_GSK-2126458_HT29_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SLITRK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9333
BORCS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49422
GSE142210_9_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K27194553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27466
GSE137137_1_v_0_rcor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7048-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-6211-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SAMD8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00577085
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.449116
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.560847
Waist Circumference	DisGeNET Gene-Phenotype Associations	1.0	null
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.72688
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5205
GTEX-WRHU-0726-SM-3MJFL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.05574
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LN319	Achilles Cell Line Gene Essentiality Profiles	-1.0	-3.56235
BRD-A19037878_trichostatin A_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
USF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-KD-A5QU-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.648
RDH5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59325
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-1326-SM-47JXB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83666
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02429
BRD-K69932463_AZD-8055_HME1_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RAPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89707
smoothmuscle_8b	HPA Tissue Sample Gene Expression Profiles	1.0	1.76653
FEV	JASPAR Predicted Transcription Factor Targets	1.0	null
Main axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.059
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.882377
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NQ-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Caudoputamen	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08804
orbital frontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06851
H3K27me3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACHN	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.965254
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.900425
hsa-miR-4645-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.341639
GTEX-SIU7-1626-SM-4BRUK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897153
BRD-K81418486_vorinostat_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.060623
generated	GeneRIF Biological Term Annotations	1.0	null
BRD-A63346720_Rimcazole dihydrochloride_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ATAD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51082
GSE186440,GSE186443_1_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NUP205	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30329
Baicalin_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0237347
TUT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.04762
PLTP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94477
NR2F2	ENCODE Transcription Factor Targets	1.0	null
CRCGN015_MCF10A.TP53.M_24H:O24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2641
BRD-K97688756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05927
PSPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12143
Perturb_5907_KD_EXOSC10_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.6221
CEBPB-21427703-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1866
Pancreas	GTEx Tissue Gene Expression Profiles 2023	1.0	1.4182
TSSK1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00524887
EGR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00666823
GSE152699,GSE152723_3_v_2_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
effects	GeneRIF Biological Term Annotations	1.0	null
GTEX-Q734-0826-SM-48U1G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914851
BRD-K28483134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41063
BRD-K22631935_13224_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K47410882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27332
GSE226249_0_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-BrtoFay_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
TMEM126B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67292
superficial stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02814
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.02822
BRD-K72414522_AZD-5438_HME1_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10807
Lung adenocarcinoma_LUAD_TCGA-62-A470-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE165636_0_v_4_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Parabrachial nucleus, lateral division, dorsal lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16839
WHSC1	ENCODE Transcription Factor Targets	1.0	null
GSE137818_3_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
calcitriol_homo sapiens_gpl570_gse35925	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC2A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00708596
cancer	GWASdb SNP-Disease Associations	1.0	0.114242
BRD-K93747373_HG-5-113-01_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
MAP1S	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64147
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040771
endometrium	HPA Tissue Gene Expression Profiles	1.0	1.08391
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	1.0	null
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06918
MXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7775
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02301
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.868579
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.856106
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hkcnq1	GeneRIF Biological Term Annotations	1.0	null
GSE213632_1_v_6_acod1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF296	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59604
AEBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46362
Lung squamous cell carcinoma_LUSC_TCGA-37-5819-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A58767537_afatinib_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Anterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.93194
BRD-K65250438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.64034
regulation of cardiac muscle cell membrane repolarization	GO Biological Process Annotations 2025	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58485
upper respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.581217
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
CCDC86	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00439195
GSE178255_5_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WV-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MFGE8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50723
OLFM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00533475
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.65864
PANC0213	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57425
KYNU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.010396
CD47	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00577105
avian pallium	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PKD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11358
CD164L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04168
AR-22383394-PROSTATE-CANCER-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Ribociclib_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0277982
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25135
BRD-K37262603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6542
superficial stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28762
HOXA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59491
mediodorsal nucleus of thalamus_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09569
action potential	GO Biological Process Annotations 2025	1.0	null
BLK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00763615
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4769-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K60848736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01896
dorsal endopiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.26921
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TMMY-2226-SM-4DXTN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46223
GSE164874_5_v_12_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39492
BRD-K63675182_TRIFLUPROMAZINE HYDROCHLORIDE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCDC158	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00653379
CRCGN015_MCF10A.WT.HP_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05704
cation-transporting ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.734
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
BRD-K21680192_mitoxantrone_PC3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-499a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
superficial stratum of r3BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2681
PMC5993422-NIHMS922534-supplement-Sup_Tables_1-23.xlsx-RELA-EnhancerAssociatedGene-Unnamed_3_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0535
SNU119	CCLE Cell Line Gene Expression Profiles	-1.0	-2.25249
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11971
BARHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9971
BRD-K62169556_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEx Uterus 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-4.43251
PMC12575911-43556_2025_329_MOESM2_ESM.xlsx-SD2_MITF_CoBindingGenes-Gene_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CCNH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00437403
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
MSTN_DEPLETION_GDS3637_94_mouse_mature skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ITPRIPL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0105981
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2278
FES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86586
Belumosudil (mesylate)_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0115677
PMC7608835-aba3058_Table_S4.xlsx-EWS-FLI1_RING1B-Genes_containing_RING1B_EWSR1-FLI1_enhancers_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
BTG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00530656
BRD-K91268803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.127
cho-k1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.866842
Lymphocyte count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.6
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45733
mediodorsal nucleus of thalamus_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13214
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7831-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045343
BRD-K62248885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.762
ARMC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98147
OB olfactory fiber layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26523
orbital frontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21944
GSE242199_2_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K62979806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60455
BRD-A38749782_FLUDROCORTISONE ACETATE_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DIPK1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9295
JHESOAD1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.08753
vertical nucleus of the diagonal band	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01681
MAX	ENCODE Transcription Factor Targets	1.0	null
renal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.109587
hsa-miR-520h	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
647-V	COSMIC Cell Line Gene Mutation Profiles	1.0	null
JUN-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE193588_3_v_2_pax3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PVRIG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41553
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
NCIH2066	CCLE Cell Line Gene CNV Profiles	1.0	1.46445
Brain Lower Grade Glioma_LGG_TCGA-FG-6692-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PSG4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00719503
IL12RB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00531008
BRD-K37015376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36144
letrozole_homo sapiens_gpl3921_gse33366	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Jervell-Lange Nielsen syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.755
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_2587_KD_NUDT3_SRP066365	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Cochlear duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.188
Skin-muscle cell	Tabula Sapiens Gene-Cell Associations	1.0	0.902985
ESRRB-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GIMAP7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00610382
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE232631_0_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TCEAL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00465671
concluded	GeneRIF Biological Term Annotations	1.0	null
GTEX-TMMY-0626-SM-33HBD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08894
CACNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78769
BRD-K77032979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01963
NANOG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00492304
r3 part of anteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02814
Medial amygdalar nucleus, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.32155
GTEX-PWCY-2226-SM-2S1OP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26244
SCA1_Knock-in_GDS1756_231_mouse_Cerebellum tissue - 4 weeks of age	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SOCS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20545
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBX20	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1491
BRD-K07385991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87532
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0723
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.919787
fallopiantube_8c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.11485
amygdala	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Transmembrane transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8203
GTEX-PSDG-1326-SM-48TD2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849521
GTEX-S4P3-1826-SM-3K2AL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833044
hsa-miR-3926	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
TARDBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60271
acute leukemia	GWASdb SNP-Phenotype Associations	1.0	0.410331
E2F6_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.567626
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19173
HUS1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90663
DRD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00449312
BRD-K16485616_mocetinostat_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A79768653_sirolimus_BT20_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PRXL2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5807
EFO21	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.03925
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5378-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.904954
regulation of ventricular cardiac muscle cell membrane repolarization	GO Biological Process Annotations 2023	1.0	null
Allopurinol_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0162246
organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.15771
ANXA9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00757676
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.883838
potassium ion transmembrane transport	GO Biological Process Annotations 2023	1.0	null
CDR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14686
16141321-Table2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XYKS-1626-SM-4BRUQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07991
primary motor-sensory cortex (samples)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19517
BRD-K49865102_PD-0325901_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26005
PATL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00783914
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.832
Docetaxel_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0293268
GOT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00596266
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.30696
Bladder-smooth muscle cell	Tabula Sapiens Gene-Cell Associations	1.0	0.466739
BRD-A45889380_QUINACRINE HYDROCHLORIDE_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SREBF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0047679
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.07908
SHMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15462
abnormality of leukocytes	GWASdb SNP-Phenotype Associations	1.0	0.129792
Retrosplenial area, lateral agranular part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.09697
DCAF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02689
GTEX-N7MS-0626-SM-2YUN7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36942
GSE227592_4_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.274608
GSE130217_0_v_2_sesn2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T2IS-2226-SM-4DM65	GTEx Tissue Sample Gene Expression Profiles	1.0	2.77268
YY1	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
MSTO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0066869
Sudden infant death syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.416
GSE142210_2_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.85836
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.18935
PMC11554218-ppat.1012673.s015.xlsx-Sheet_A-IRF1_Target_Gene_Lists_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
OLIG2	ChEA Transcription Factor Targets	1.0	null
contractile fiber part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.114042
UOK101	Achilles Cell Line Gene Essentiality Profiles	1.0	1.27927
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3156
GTEX-OXRO-0226-SM-3LK6F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36764
B3GNT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56531
GSE125153_1_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U412-0226-SM-3NMC8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16249
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20R-11A-11R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MTMR11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73603
NXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56923
potassium ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
H3K9ac_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K16966765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24425
ZNF711	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91274
regulation of heart rate by cardiac conduction	GO Biological Process Annotations 2023	1.0	null
PMC8881251-18_2022_4183_MOESM2_ESM.xlsx-ERM_vs_P1-DEGs_ERM_versus_P1_organoids_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
IKZF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22616
ZNF883	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78362
MCF7	CCLE Cell Line Gene Expression Profiles	1.0	1.3741
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Anhidrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.412
r8 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37334
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06403
Fetal Lung	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.40262
COL4A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00595929
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01831
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
T98G	CCLE Cell Line Gene Expression Profiles	1.0	1.40915
Oxyntic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.338
RNF181	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36481
LN428	Achilles Cell Line Gene Essentiality Profiles	1.0	1.09343
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060394
hsa-miR-4459	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11745
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42248
BRD-K48358706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44238
TBX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94722
Hypertrophic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
MRPL39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3057
GTEX-O5YV-0626-SM-3LK64	GTEx Tissue Sample Gene Expression Profiles	1.0	2.51325
H3K9me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A7WH-01A-22R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIRT1_KO_GSE28790_47_mouse_brain (3 mo)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28476
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.276
BCL2L14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608151
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Genes_differentially_expressed_upon_CSL_silencing_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60566
GSE227592_10_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Edema	CTD Gene-Disease Associations	1.0	1.11606
brugada syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.761862
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887436
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20817
GTEX-OIZH-1826-SM-2YUNP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89212
cation channel activity	GO Molecular Function Annotations 2015	1.0	null
drastic	GeneRIF Biological Term Annotations	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K86797399_pracinostat_HA1E_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SF539	BioGPS Cell Line Gene Expression Profiles	1.0	0.857093
Left atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.209
Primary somatosensory area, unassigned, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11548
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.294223
BRD-K79239947_PF 573228_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
potassium channel regulator activity	GO Molecular Function Annotations 2025	1.0	null
Primary somatosensory area, nose	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35959
H2BK120ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216757_4_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Calcitonin family receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.008
IL23R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00960188
BRD-K97013733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03766
GTEX-QDVJ-1326-SM-48U1X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26306
GTEX-WWYW-0826-SM-3NB2X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921596
Brain Lower Grade Glioma_LGG_TCGA-HT-7882-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_13750_KO_Bcl3_SRP179718	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.5605
smoothmuscle_8a	HPA Tissue Sample Gene Expression Profiles	1.0	1.09952
BRD-K81814927_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-NPJ8-0526-SM-3MJHN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79145
GTPBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00539156
BRD-K50210179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05994
Perturb_8874_OE_TCF21_SRP081577	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
posteroventral (inferior) parietal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16294
Learning Disorders	CTD Gene-Disease Associations	1.0	1.45299
PIM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00481006
GSE214931_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Six3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.4409
MANBA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98959
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VENTX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32188
CRCGN017_MCF10A.WT.HP_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5408
BRD-K58835676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2042
GSE261563_6_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
ADM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00581926
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ALDH1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99777
time	GeneRIF Biological Term Annotations	1.0	null
BRD-K35026224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08785
BRD-K31412180_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PGM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84443
related	GeneRIF Biological Term Annotations	1.0	null
PFN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05981
PMC8814143-41419_2022_4530_MOESM12_ESM.xlsx-down_ZNF32_vs_Vector-Unnamed_1_ZNF32	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4777381-pone.0150624.s006.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
18425577-TableS3b	GeneSigDB Published Gene Signatures	1.0	null
GP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0050454
bronchial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.323002
ACTR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32837
peak	GeneRIF Biological Term Annotations	1.0	null
BRD-K10148216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29463
pharynx cancer	GWASdb SNP-Disease Associations	1.0	0.481016
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.13277
GTEX-PWCY-1426-SM-48TCT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35884
HDAC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00428154
leukemia	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.15771
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
betasubunit	GeneRIF Biological Term Annotations	1.0	null
DDX21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00423521
HS683	Achilles Cell Line Gene Essentiality Profiles	1.0	1.20257
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZFX_02_172	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.08746
BRD-K05479183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67123
MBOAT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72352
UBA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.51266
CPXCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95621
RPSA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8699
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91997
FAM76B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57997
external part of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65572
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.968945
ALDH3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73839
FFAR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00389572
allergic	GeneRIF Biological Term Annotations	1.0	null
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.86933
GSE214505_0_v_1_akr1b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-2355-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
TRIM28-17542650-NTERA2-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18509
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4326-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DCUN1D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00676688
SUMO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00510986
cochlear nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15968
BRD-K50234570_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE195663_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
excretion	GeneRIF Biological Term Annotations	1.0	null
BRD-K87909389_alvocidib_HME1_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8C_Het1A-HNF4A_2d_5x_closed-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.913353
CENPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15437
SLR24	Achilles Cell Line Gene Essentiality Profiles	1.0	1.2499
SH2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55
FST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62047
CBX2-22325352-293T-REX-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
intermediate stratum of Str	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02314
RAB11FIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30184
mantle zone of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20921
GSE233679_14_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
KCNA1	Pathway Commons Protein-Protein Interactions	1.0	null
TCF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1193
FASTK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2174
TNPO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71068
CDKN1C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00539205
OSBPL6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608983
ZFP69B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34106
Liver hepatocellular carcinoma_LIHC_TCGA-5R-AA1D-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K99581286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.49129
GSE137818_2_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NIN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00699893
STAMBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16019
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16756
GSE146074_6_v_11_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
kcne1kcnq1kcne4	GeneRIF Biological Term Annotations	1.0	null
LYAR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0072409
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
TOV21G	Achilles Cell Line Gene Essentiality Profiles	1.0	1.30297
BRD-K78431006_crizotinib_SKBR3_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BCS1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97164
PC14	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K21680192_mitoxantrone_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K16485616_mocetinostat_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAN1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7068
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46448
phenotype	GeneRIF Biological Term Annotations	1.0	null
RRAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.10328
BRD-K76691746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21202
IP6K1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79516
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HD-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHP126	CCLE Cell Line Gene CNV Profiles	1.0	2.13679
SRMS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0042679
PHIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23078
CD40	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00451529
BRD-K90360779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04676
HSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38398
USF1	ENCODE Transcription Factor Targets	1.0	null
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AGAP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77478
Posterior parietal association areas, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24797
disease of metabolism	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.274608
superficial stratum of PCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06377
BRD-K41731186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39208
Cilostazol_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.033377
KLHL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86324
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SLC25A36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28941
Memory Disorders	CTD Gene-Disease Associations	1.0	1.38185
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18509
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849802
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
MED22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63369
CCNT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490231
polymorphism	GeneRIF Biological Term Annotations	1.0	null
Atrial fibrillation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.053
DUSP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95905
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955303
SUCNR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00481555
abnormality of cellular immune system	GWASdb SNP-Phenotype Associations	1.0	0.129792
hsa-miR-1284	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07058
ALKBH7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34428
JL1	CCLE Cell Line Gene CNV Profiles	1.0	1.51943
GSE94849_1_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
MDA-MB-231	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.960034
Anterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87441
leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068704
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.843758
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.18293
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13274
BRD-K40927841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01294
Temporal lobe	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CLOCK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6332
AZD-7648_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0136244
cardiac conduction	GO Biological Process Annotations 2023	1.0	null
DU145	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.36588
GSE118430_0_v_1_xbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TFEC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5687
medial parabrachial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05917
GSE168097_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TGFB1I1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33031
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.25383
hsa-miR-4713-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_5947_KD_PRMT1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.9356
Secondary motor area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03908
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6789-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-G5-6572-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RWDD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79322
ZFYVE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99046
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17873
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cuneate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16263
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TNFAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92997
ENDOV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.33253
ventrolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38141
P300-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
mcf7	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
CAPRIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00755154
transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE186440,GSE186443_2_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
Stomach Smooth Muscle	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.08775
BRD-K87947369_VX-680_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
passive transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE142210_3_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXP2	ENCODE Transcription Factor Targets	1.0	null
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.978416
stratum pyramidale of rostral CA3	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.63203
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06512
upon	GeneRIF Biological Term Annotations	1.0	null
BRD-K22949587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3992
peripheral portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13122
Posterior parietal association areas, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00732
RPS19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22492
PLA2G1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00812089
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hematologic cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.15771
BRD-K96615474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08599
Primary somatosensory area, barrel field, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43305
BRD-K06355852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24758
FAM234A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8363
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.566428
NPEPPS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00629107
BRD-K90382497_-666_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K74817844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35102
ZFYVE16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34811
JOSD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17368
intermediate stratum of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20373
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-Gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K19796430_LDE225 (NVP-LDE225)_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K74761218_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.19868
hsa-miR-4742-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
GTEX-PWN1-0008-SM-48TEA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996141
SMARCA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00488095
NNT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.36245
BRD-K36042673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29124
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.38
INSYN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50388
KE39	CCLE Cell Line Gene CNV Profiles	1.0	1.59957
intermediate stratum of the PBC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05976
GSE242199_2_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KAT6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0033928
Primary somatosensory area, mouth, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52176
18537972-TableS3	GeneSigDB Published Gene Signatures	1.0	null
TMEM79	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65725
GTEX-X4XY-0526-SM-46MW1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61471
GSE144443_5_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TAB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5902
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
substrate-specific transporter activity	GO Molecular Function Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TJ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSK1059615_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0169014
ARF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82131
BRD-K76329122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33738
Perturb_5923_KD_KHDRBS3_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.59537
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17617570-Table2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K76401790_JNK-IN-5A_A375_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K09523238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54134
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04381
AADACL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00511601
BRD-K00048792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52452
ATP2A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5378
ZNF808	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05247
potassium channel activity	GO Molecular Function Annotations 2015	1.0	null
GSE136397_1_v_0_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GATAD2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65653
PMC8387919-mmc2.xlsx-ST8_NEUROG3_and_islets_expr-Unnamed_2_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11329632-41419_2024_6969_MOESM3_ESM.pdf-25-CREBL2_CREBL2	Rummagene Transcription Factor Associations 2026	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.245046
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NF-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
negative regulation of voltage-gated potassium channel activity	GO Biological Process Annotations 2023	1.0	null
GSE165939_2_v_1_poldip2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XOT4-0426-SM-4B66T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918291
transport	GO Biological Process Annotations 2015	1.0	null
ventrolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22612
bwtg3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.963
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3997
SERPINH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70129
PCDH17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00730258
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE101767_1_v_0_wdr11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
basolateral amygdaloid nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39421
mammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50033
Mammary-vascular associated smooth muscle cell	Tabula Sapiens Gene-Cell Associations	1.0	0.167654
RTBDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41829
RAD21_02_190	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.60768
496100516_FWM_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.36258
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34066
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K76645599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18777
Prestwick-1085-5774	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
u87	HPA Cell Line Gene Expression Profiles	1.0	0.925568
CHRNA9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00781516
BRD-K87666020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.47284
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DOK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96344
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985035
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05116
PMC10274745-media-4.xlsx-S3B-Table_S3_Reanalysis_of_publicly_available_data_to_identify_AR_and_ER_direct_target_genes_related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FAAH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00474556
GSE184892_6_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
MIER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23395
GSE213219_2_v_3_st3gal3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SLC39A14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00801994
GSE184892_6_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
ILF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76655
SOX21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27088
Nucleus of the lateral olfactory tract, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.78229
SG in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.8519
BRD-K01960204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77934
Doxycycline (monohydrate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0155218
SHROOM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37009
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.2427
primary motor-sensory cortex (samples)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.849268
ventral lateral nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.929728
BRD-K38969544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00109
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.166
hsa-miR-421	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
ZBTB38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83218
GSE180200,GSE180201_5_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0915
ZNF382	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18596
GSE242367_1_v_0_dpp9_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A58767537_afatinib_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
potassium channel complex	GO Cellular Component Annotations 2025	1.0	null
BRD-K65166009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1401
Anterior hypothalamic nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31929
BRD-K87383650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21936
GSE213588_10_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Subparaventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00075
plant vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.650966
PKN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85973
CERK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2735
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.891553
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0805
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0413
GTEX-U8XE-0626-SM-3DB8U	GTEx Tissue Sample Gene Expression Profiles	1.0	2.42757
CLPX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39461
GTEX-PWOO-1226-SM-48TCO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64371
GTEX-XV7Q-0326-SM-4BRVM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.94701
Artery - Aorta	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.73208
CDK7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00327808
sublayer 6a of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04194
Atrioventricular block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.174
BRD-K87161673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43699
single	GeneRIF Biological Term Annotations	1.0	null
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blood vessel	GTEx Tissue Gene Expression Profiles	1.0	1.05559
GTEX-XYKS-1826-SM-4E3JV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935594
DUSP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08819
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
uterus	GTEx Tissue Gene Expression Profiles	1.0	1.49366
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SDR42E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28626
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5468-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sublayer 6b of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05283
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.945234
layer 6a of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29868
salivary gland	HPA Tissue Gene Expression Profiles	-1.0	-1.02542
PCGF4-22325352-293T-REX-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
A549_ENMD-2076_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129982
GSE142210_2_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
FIZZ2_KO_GDS4902_408_mouse_Lung	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE166944_0_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PI4K2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70991
SUZ12-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SP in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.89545
GTEX-XUJ4-1526-SM-4BONU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03435
GTEX-TKQ2-0926-SM-4DXU5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41887
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
acute leukemia	GWASdb SNP-Disease Associations	1.0	1.10764
CRCGN017_MCF10A.WT.HP_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.818
kcne1	GeneRIF Biological Term Annotations	1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.57774
BRD-K89085489_GR-103_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DICER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23005
PNKP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59046
ANKK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0054892
PMC3022822-1471-2164-12-11-S10.XLS-Suppl_7_newLN229_SOX2_KO_MOCK_2-Unnamed_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.875519
BRD-K28029070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17073
USF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hematological neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.206149
Prostate adenocarcinoma_PRAD_TCGA-HI-7168-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60389
MOB3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56753
BRD-K86574132_-666_MCF7_6.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMPCA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00376426
plasma membrane region	GO Cellular Component Annotations 2015	1.0	null
BRD-K52657580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17327
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19388
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2006
GSE199606_5_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876412
BRD-K85606544_HKI-272_SKMEL28_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.32555
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPARD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00420075
primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.920478
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2899-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KBTBD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00819993
TMEM161A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81045
TBX21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00545127
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.936257
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12513
telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
stratum radiatum of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15997
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.42994
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ERMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.76565
MOTN1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.82492
PHRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15135
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CD8B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00624179
PLD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00594988
GTEX-QVUS-0426-SM-48FE3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31708
MRPS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86232
BRD-K91876603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17742
BCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49914
BRD-K48780709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16486
NBEAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3675
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2608
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25684
BRD-K54507743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01063
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A85860691_chaetocin_SNGM_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02637850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65395
HADHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2757
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
BRD-K64264263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11145
DHRS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00859181
HOXA13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0047858
AMOT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68714
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1455
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56929
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AM-095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37352
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24376
dorsolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.49375
Raltitrexed_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0204302
BRD-K54351101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1427
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2719
pacemaker cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.55408
superficial stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.85606
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JUND-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3C13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42201
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31774
membrane repolarization during action potential	GO Biological Process Annotations 2023	1.0	null
MT-ND5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83094
BRD-K00615600_AG14361_SW620_6.0_h_25.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RSPRY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65604
NHEJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5328
LN428	CCLE Cell Line Gene Expression Profiles	1.0	1.48283
mantle zone of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06377
GSE253089_0_v_1_ephb2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Aspirin_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0185092
Atrial Fibrillation	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K10917236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59409
Perturb_13136_KO_Gadd45a/Ing1_SRP149486	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-16.601
transporter activity	GO Molecular Function Annotations 2015	1.0	null
COV318	CCLE Cell Line Gene CNV Profiles	1.0	1.47604
ALAS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00269658
Acute Myeloid Leukemia_LAML_TCGA-AB-2987-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35075
Ferulic acid_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0201734
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PAFAH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82456
Diastolic Blood Pressure	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K40329609_NCGC00184830-01_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DUSP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00437452
Wt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	74.945
NCBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00864356
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74402642_Chemistry 2804_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Recurrent major depressive disorder x sex interaction	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.522185
HRAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0096
C32	Achilles Cell Line Gene Essentiality Profiles	1.0	1.30225
CRCGN017_MCF10A.TP53.M_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.153
NID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2043
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060069
ICOSLG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00724471
ventral tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35976
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
C32	CCLE Cell Line Gene CNV Profiles	1.0	1.7307
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3K_Peaks_wtYAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
IRX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90618
BRD-K08205503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30639
Spinalcord	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.841743
HCC2814	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40964
encoded	GeneRIF Biological Term Annotations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A264-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
apical plasma membrane	GO Cellular Component Annotations 2015	1.0	null
primary motor cortex (area M1, area 4)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.11056
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.249
SNX17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54674
layer 6 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18175
medial mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55177
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PTGER1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00536899
VCAP	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.06261
calmodulin	GeneRIF Biological Term Annotations	1.0	null
GMPR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00479217
RRP36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03985
CD177	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0062712
caudal prosubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01602
NDRG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53593
CDC42SE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33897
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.5546
ORC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67655
NCIH209	CCLE Cell Line Gene CNV Profiles	1.0	1.62361
HS852T	CCLE Cell Line Gene CNV Profiles	-1.0	-2.09016
Inflammation	CTD Gene-Disease Associations	1.0	1.97332
BRD-K71726959_N9-isoproplyolomoucine_WSUDLCL2_6.0_h_122.55_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
shoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061214
BRD-K82683018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2861
kv11	GeneRIF Biological Term Annotations	1.0	null
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.61555
uterus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46873
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.41527
HCC38	CCLE Cell Line Gene CNV Profiles	1.0	1.34367
Cerebral ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.165
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.306
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17695
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.521
TMEM102	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86642
Perturb_9489_KO|KD_Prdm16|Appbp2_SRP359770	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
putamen	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37522
GTEX-R55G-1626-SM-48FF4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.17172
GSE158197_6_v_10_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K17858048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27773
C4BPA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00791194
BRD-K80782159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35215
allergic rhinitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.761454
H3K79me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
UBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.96804
C15orf62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87071
Anorexia	CTD Gene-Disease Associations	1.0	1.01474
hsa-miR-424	TargetScan Predicted Conserved microRNA Targets	1.0	0.031759
GSE135439_0_v_1_pax5_human	RummaGEO Gene Perturbation Signatures	1.0	null
plexiform layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85602
H3K27me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-PLZ4-2826-SM-3P617	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925976
cancer	GAD High Level Gene-Disease Associations	1.0	0.295739
ERCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80505
BRD-K17574409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02117
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955468
Primary motor area, Layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84991
UMUC1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49173
sarcolemma	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.398587
BRD-K68548958_-666_SKLU1_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MITD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84647
K562	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.13786
BRD-K07762753_Aminopurvalanol A_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
P2RY8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00573178
Terfenadine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0198986
BEND3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00828642
SCML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61818
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.908882
BRD-K67868012_PI-103_A375_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K74148702_curcumin_HA1E_6.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
(S)-Crizotinib_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0121225
r6 part of ventral gigangocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0465
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26581
FOXD4L5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53311
ACVR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62299
spanning component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.598538
myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.096538
BRD-K14309706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71118
plumule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067847
PSMF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27159
hsa-miR-1305	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
SMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30763
amygdaloid complex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.939022
rhinitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.700321
CFH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00885836
KYSE-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.83714
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43202
PMC11825621-210_2024_3353_MOESM2_ESM.xlsx-AR-IL13_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K78856515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09795
BRD-K26582498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14731
nucleus of the lateral olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67979
GTEX-Q2AG-0926-SM-48U1Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32964
blood	GTEx Tissue Gene Expression Profiles	-1.0	-2.10021
GSE196699_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K00557942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41325
GTEX-T5JC-0011-R2A-SM-32PLZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00475
GSE95543_1_v_0_klhl41_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00805
FAM200B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00571618
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.33
GSE173394_1_v_0_nfatc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93130549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00722
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32682
Primary somatosensory area, barrel field, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4119
CUX1-19635798-MULTIPLE-CANCER-TYPES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.981843
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.03174
OPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54256
abnormality of blood and blood-forming tissues	GWASdb SNP-Phenotype Associations	1.0	0.065111
BRD-K02407574_Parbendazole_VCAP_24.0_h_0.31_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0912
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.78341
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911874
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.170098
EBF1-22473956-BONE-MARROW-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TLCD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83439
CBX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35998
arcuate nucleus of medulla, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.4609
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.901992
rpmi8226	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
TROAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08497
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.4685
BCKDK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32456
SREBF1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE223241_1_v_3_cdkn2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RAB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22361
GTEX-QV31-1626-SM-2S1QC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25725
Indacaterol (maleate)_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0235932
ESR1-22446102-UTERUS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PRR14L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00458674
BRD-K91937579_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE179002_2_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242367_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184892_7_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
integral component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.536594
H3K79me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAPK7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00680317
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4999-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Paclitaxel_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0294468
monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.337975
PCDHGC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49595
NPM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57479
biological regulation	GO Biological Process Annotations 2015	1.0	null
BRD-K60799989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35924
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5KH-06A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
19658189-TableS4	GeneSigDB Published Gene Signatures	1.0	null
germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.651371
496100495_FWM_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.46291
CRCGN016_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8301
ZR-75-30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
current	GeneRIF Biological Term Annotations	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05521
ERVMER34-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07579
BRD-K96839404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20565
ARL6IP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32941
hsa-miR-4501	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
abnormality of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.149632
hsa-miR-548ah	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
HOXC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5436
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959688
Lung adenocarcinoma_LUAD_TCGA-75-6212-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
u138mg	HPA Cell Line Gene Expression Profiles	1.0	1.06405
GSE85565_1_v_0_tcf21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Fetallung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.04176
CRCGN015_HEPG2_48H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.25769
MSH5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19412
SEC23A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34995
Prostate adenocarcinoma_PRAD_TCGA-EJ-7123-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD302	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00494123
cardiac muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.297806
BRD-K34360192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29143
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K73739802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90649
BRD-K09499853_KU 0060648 trihydrochloride_RMUGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-U60236422_WH-4-025_BT20_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TLE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09725
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
r3 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02412
regulation of cardiac muscle cell membrane repolarization	GO Biological Process Annotations 2023	1.0	null
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41937
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13866
BRD-K79735667	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23953
BRD-K69089961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6821
ERBIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67811
BRD-K49328571_dasatinib_MDAMB231_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UACC257	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.55447
16491124-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
A-Netherlands-602-2009(H1N1)_48Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.74747
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05927
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.293334
S100Z	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00664709
BRD-K83643280_BG FA 0953_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K82504878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00375
goiter	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.42739
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5VV-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2341
EBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75615
BRD-K64404450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00846
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hippocampus	HPA Tissue Protein Expression Profiles	-1.0	-1.41887
TP53-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE111035,GSE111040_8_v_9_plag1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Fluvoxamine (maleate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0230715
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.844358
GSE63048_11_v_5_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6934-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
ADD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3249
hsa-miR-4668-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.026857
GSE87412,GSE92423_3_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Anterolateral visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46812
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31317
Perturb_8504_KO_Hr_SRP200420	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.24157
FGFR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00764726
BRD-K63111122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13219
Myometrial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.811
MBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59395
increased cardiac muscle relaxation	MGI Mouse Phenotype Associations 2023	1.0	null
PMC6344081-elife-40364-supp5.xlsx-PLZF_peaks_H3K27Ac_unchanged-Unnamed_10_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
AMDHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10944
GABRA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0046225
mammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49863
BRD-K86584551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22127
biological_process	GO Biological Process Annotations 2015	1.0	null
UBA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00768507
same	GeneRIF Biological Term Annotations	1.0	null
GTEX-RUSQ-1926-SM-2TF6K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60288
GTEX-S3XE-1326-SM-4AD4H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14125
BRD-K81418486_vorinostat_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
coassociate	GeneRIF Biological Term Annotations	1.0	null
GSE197555_0_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OHPN-0226-SM-48TBV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952949
paraventricular nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.954238
STAC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0047695
apical part of cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.159268
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4620-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gli2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.5104
GSE224311_3_v_0_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary somatosensory area, nose, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22947
cation transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14453
SLC41A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00656379
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-A5DJ-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF530	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55311
H2BK20ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GPM6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00537443
BRD-K71799778_BML-259_U937_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ERF::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8454
hsa-miR-3148	TargetScan Predicted Conserved microRNA Targets	1.0	0.175726
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A52650764_Ingenol 3, 20-dibenzoate_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8423-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92043
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bed nuclei of the stria terminalis, anterior division, oval nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4644
REC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68198
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.836145
ventrolateral periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37533
Tachycardia_Myocardial tissue_GSE7999	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.58798
NUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7888
LANCL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00555704
SCN10A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00746507
TMEM86B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53277
cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TIAL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00570953
BRD-K48046422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82889
PPIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25457
BRD-A43409498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01321
OVCAR8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48779
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
P53-22387025-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3124-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE125153_1_v_3_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073567
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2412
rh30	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
BRD-K47170544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0917
KLRB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0077324
BRD-K71035033_masitinib_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A75409952_wortmannin_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.27894
ANKRD50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83032
GTEX-P4QT-1826-SM-2S1NJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916824
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900721
CRCGN008_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2443
GSE138050,GSE148257_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUCKS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00386572
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
XRK3F2_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0221779
red nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00335
FOXI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52635
Perturb_11612_KD_BRD8__SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.6933
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50244
EXT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51586
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SFMBT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00832126
Perturb_2819_OE_ADHFE1_SRP073667	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.26205
olaparib_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0601456
TSHZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75582
BRD-K69852452_F1566-0341_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K63068307_ZSTK-474_HME1_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K56343971_PLX-4032_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
superficial stratum of PO1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.12188
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00594
RRAS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00904808
BRD-K18856772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73359
Torkinib_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0254735
PU1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EXOSC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95032
PMC7608835-aba3058_Table_S4.xlsx-EWS-FLI1_RING1B_SEnh-Genes_containing_RING1B_EWSR1-FLI1_superenhancers_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
emboliform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04403
PDLIM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00521974
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04972
GSE171175,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.85045
BRD-K23363278_CYT997_HA1E_24.0_h_1.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KYAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34812
forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6702-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
CTTNBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69921
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.71994
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10006
UBB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58903
ML1	CCLE Cell Line Gene Expression Profiles	1.0	1.52467
Hypertension	CTD Gene-Disease Associations	1.0	1.20816
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Central amygdalar nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03735
erbB-2_OE_GDS1925_164_human_Estrogen receptor (ER) alpha positive MCF-7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
MRPL19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11983
BRD-K99764436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78263
Cells - EBV-transformed lymphocytes	GTEx Tissue Gene Expression Profiles 2023	1.0	4.00949
NDUFB9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00569196
Flutamide_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0193266
Weight	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MIR122_Antisense Inhibition_GDS1729_759_mouse_Livers (from C57BL/6 adult males)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
JIYOYEP-2003	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-W5X1-1426-SM-3GIKH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87874
plant embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066113
BRD-K01894374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09327
inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.46476
CHI3L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00684735
Systolic Pressure	DisGeNET Gene-Phenotype Associations	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE178255_1_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A42433574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23354
Primary somatosensory area, barrel field	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44154
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851185
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Daptomycin_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0291049
IGSF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00662365
GSE138815,GSE138817_0_v_2_kdm6a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K17743125_belinostat_HEPG2_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE221327_4_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K87909389_alvocidib_HME1_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Retrosplenial area, lateral agranular part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09038
MELJUSO	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45694
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19802
lung	GeneRIF Biological Term Annotations	1.0	null
Aorta cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.035
HCC827	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.35561
HSD17B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00901672
heterologously	GeneRIF Biological Term Annotations	1.0	null
Anteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64837
VPS13B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00616865
Perturb_9796_OE_Foxd1_SRP132362	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
hsa-miR-3153	TargetScan Predicted Conserved microRNA Targets	1.0	0.029271
DNAJA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.37701
KCNK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35208
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97619
BRD-K35122752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49636
ventrolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01662
lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.166768
Nucleus of the lateral olfactory tract, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45343
BRD-K30707190_PNU 74654_HA1E_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE225141,GSE225143_2_v_3_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-7004-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NGFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00736428
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29401
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6028_KD_KHDRBS1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.43825
DCUN1D4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71794
NMB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95767
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.165
H3K9me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K68202742_trichostatin A_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lymphocyte percentage of white cells	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.3301
PMC10123531-NIHMS1874945-supplement-Table_S7.xlsx-SOX17_BCAT_4TCFKO_peaks-Gene_Name_SOX17	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205976,GSE205978_1_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CD3epsilon deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39769
amygdaloid complex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.947088
GTEX-XV7Q-0008-SM-4BRWL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965595
hsa-miR-4470	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
CMTM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01934
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE227592_10_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57214
layer 3 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00624
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.340017
Kidney Chromophobe_KICH_TCGA-KL-8333-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DNPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93831
BRD-K39613696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60438
PDPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20661
Asthma	HuGE Navigator Gene-Phenotype Associations	1.0	null
Pterygium	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ADO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50603
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26238
YPEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10176
BRD-K21680192_mitoxantrone_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PLAU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80031
CD28	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00932647
BRD-K29379705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29449
BRD-K21680192_mitoxantrone_HS578T_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47545
RBM22_02_92	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	5.67243
BRD-K03070790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12386
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054224
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22367
KURAMOCHI	CCLE Cell Line Gene Expression Profiles	-1.0	-1.88816
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3M_Peaks_YAP1MAMLD1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Entecavir (monohydrate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0210649
HK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81977
MBTPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45213
GTEX-XPVG-0008-SM-4GICH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.995317
NEUROG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44755
GAREM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7601
HSFY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17109
GSE198165,GSE198166_5_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SCRN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88138
plasma membrane part	GO Cellular Component Annotations 2015	1.0	null
GSE96649_1_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
gallbladder_5b	HPA Tissue Sample Gene Expression Profiles	1.0	0.995621
Long QT syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.99
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30552
Sarcoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.356
Lung adenocarcinoma_LUAD_TCGA-86-8674-01A-21R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE129153_0_v_1_forskolin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE220520_6_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AN3CA	CCLE Cell Line Gene Expression Profiles	1.0	2.18344
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC22A18AS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00729038
Familial periodic paralysis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.558
GR-ST	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC4609150-13073_2015_228_MOESM2_ESM.xlsx-TP53-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
obstructive lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.283655
ion transport	GO Biological Process Annotations 2015	1.0	null
ADRA2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00369134
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.48005
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.8775
Primary somatosensory area, mouth	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09924
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFG7-0326-SM-3GILI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08159
HTR1E	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00982871
SOAT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00539492
SP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63992
AKR1C1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495398
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QMR6-1326-SM-32PLB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830403
Integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
SULT2A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00727145
Bimatoprost_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0152004
CDK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0333
ACAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93467
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86711
MCAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30849
MRGBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17353
Pasireotide (acetate)_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0106594
MAPK15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0089053
BRD-A36275421_2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.840629
GSE236262_0_v_3_trim28_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TMEM138	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.18894
Lung adenocarcinoma_LUAD_TCGA-78-7537-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Arrhythmogenic right ventricular cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
MICAL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03298
abnormality of the nose	GWASdb SNP-Phenotype Associations	1.0	0.367064
GSE131565_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K12184916_NVP-BEZ235_MCF7_3_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HI-TOPK-032_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0124916
BRD-K04887706_AKT-inhibitor-1-2_MCF10A_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4335-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCL1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6009
SERPINB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0047685
SCARF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0346
BRD-K65904652_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
uterus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.262986
lymphoblastic leukemia	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.15771
PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of the head	GWASdb SNP-Phenotype Associations	1.0	0.120051
BRD-K64221857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30835
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A19500257_geldanamycin_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
496100507_FWM_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.74258
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.63809
CAPN15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00630507
Vascular Diseases	CTD Gene-Disease Associations	1.0	1.29072
GTEX-OHPN-2826-SM-3LK67	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94848
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
P300-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
superficial stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26299
Perturb_15064_OE_Trp53_SRP345823	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.3083
not applicable_Hypothermia_GSE54229_131_mouse_Embryonic fibroblas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833217
GSE133213_6_v_13_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4686057-pone.0145107.s001.xlsx-PAA-CAA-Unnamed_0_TSHZ1	Rummagene Transcription Factor Associations 2026	1.0	null
PPP1R18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66802
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.8469
REST	ENCODE Transcription Factor Targets	1.0	null
GTEX-OXRO-1926-SM-2S1O3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5456
IDH3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12572
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K59095205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00057
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.811
mantle zone of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49945
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936769
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RT-A6YC-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66564
SIK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00674596
molecular layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.826984
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874284
Omeprazole_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0145539
dentate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.46723
ERF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42486
GSE221327_5_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180200,GSE180201_2_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCFC1R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37484
hsa-miR-4486	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
SERTAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28462
neoplasm by anatomical site	GWASdb SNP-Phenotype Associations	1.0	0.101817
BRD-K76611906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0101
BRD-A87137733_GSK-690693_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Medial preoptic nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14791
BRD-A60245366_AS-601245_HS578T_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A89575866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19123
SMAD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5566
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.914921
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.08879
CCL18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00740715
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CCDC85B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00378612
BRD-K76401790_JNK-IN-5A_HA1E_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892381
ARIH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00763244
NHLH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53444
METTL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78578
USF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ALOX15B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00388455
BRD-K61220632_LEOIDIN DIMETHYL ETHER_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27512
ZNF721	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89135
H3K4me1_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HOXA1_01_110	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.72177
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XYKS-0426-SM-4BRW4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18128
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
hsa-miR-4504	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
PMC12685885-Table1.xlsx-Table_S9-Du_PanCancer_ATF3_SMC_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_DEPLETION_GDS3294_97_mouse_germinal vesicle (GV) oocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.56826
CRCGN011_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.618
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NPHS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0061022
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FV-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC35E3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3758
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239844_11_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.859993
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.83714
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13154
C8G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28151
membrane part	GO Cellular Component Annotations 2015	1.0	null
GSE162892_4_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K91490997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49209
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11765
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ABL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00581798
BRD-K85532500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14465
BRD-K53414658_-666_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K67817697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15536
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211126_3_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K02206127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34293
BRD-K79090631_CGP-60474_MCF7_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-26a	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
BEN	CCLE Cell Line Gene Expression Profiles	1.0	2.65489
Cardiomyopathy_Myocardial tissue_GSE1869	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.69128
PHF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21275
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K47869605_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K43389698_BMS-387032_HS578T_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	GO Molecular Function Annotations 2025	1.0	null
SMAD2/3-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CARMIL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00818216
PDCD10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00680346
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17017
Mammary-pericyte cell	Tabula Sapiens Gene-Cell Associations	1.0	0.342914
GSE226249_2_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K97263385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24421
NPIPA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75638
modulates	GeneRIF Biological Term Annotations	1.0	null
NCI 460	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
nucleotide	GeneRIF Biological Term Annotations	1.0	null
Perturb_11652_KD_MAP3K6_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.08426
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2M7-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ART1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060709
IFNA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00540495
RUNX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29435
Lung adenocarcinoma_LUAD_TCGA-MP-A4TD-01A-32R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZG-0008-SM-4E3J2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26488
DTX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32094
ZKSCAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84941
Perturb_11522_KD_RNF20_SRP091771	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.2049
Prostate adenocarcinoma_PRAD_TCGA-G9-6342-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0463
TMEM199	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68251
BRD-K94176593_TWS-119_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Acetohexamide_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.02794
GTEX-X4EP-0826-SM-3P5YK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52634
periventricular stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0553
Acute Myeloid Leukemia_LAML_TCGA-AB-2873-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
currents	GeneRIF Biological Term Annotations	1.0	null
STAC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00614706
RBBP5	ENCODE Transcription Factor Targets	1.0	null
nucleus of the central acoustic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20782
GSE51684,GSE51741_2_v_4_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
basal ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_6475_OE_circAKT3_SRP216548	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MMP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41682
NMYC-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZNF749	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50837
E2F6	ENCODE Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SO-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12779
BRD-K49328571_dasatinib_HS578T_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DNAJC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24412
Reticulocyte count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0301
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.877366
BRD-K54260552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10683
R3HDM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68173
CCNP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71157
layer IIIu of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38601
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.232489
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8567280-EMBR-22-e53014-s007.xlsx-Sheet1-Nearest_genes_to_BAZ2A-bound_C2-Enhancers_BAZ2A	Rummagene Transcription Factor Associations 2026	1.0	null
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE239541_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K60719499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33098
PTBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19911
strongly	GeneRIF Biological Term Annotations	1.0	null
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33552
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17985
DIPK2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52041
GSE145639_7_v_6_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
PK1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54125
GTEX-WEY5-0526-SM-3GIKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25496
GSE188458_2_v_4_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PANO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81654
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.553286
GSE134896_0_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
associates	GeneRIF Biological Term Annotations	1.0	null
BRD-K70940767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58739
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
skeletal	GeneRIF Biological Term Annotations	1.0	null
BRD-K74251295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.43232
SYPL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00809342
GSE176093_0_v_3_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MZ2-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1455
GSE178255_1_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X4XX-0926-SM-46MV7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.882047
SNUPN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00817873
H4C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54457
BRD-K62459624_T5212475_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Intrinsic component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
RASSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48746
EP300-20729851-FORBRAIN-MIDBRAIN-LIMB-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
member	GeneRIF Biological Term Annotations	1.0	null
PMC8410083-elife-65574-fig7-data1.xlsx-KLF10_network-Genes_bound_by_KLF10_in_their_-10_1kb_region_or_differentially_expressed_in_WT_vs_HepKO_hepatocytes_challenged_with_high_sugar_KLF10	Rummagene Transcription Factor Associations 2026	1.0	null
POLDIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10398
GSE196699_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
L-Eflornithine (monohydrochloride)_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00870704
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.22098
BRD-K91084609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22653
NG25_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0280773
ZNF81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19508
LAG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00666364
CALML4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66297
STAT5A_02_182	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.24793
SLC38A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00637983
etomidate-3519	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC6855629-pone.0225186.s008.xlsx-Sheet1-DEGs_upregulated_in_SK-N-SH_MEIS1_OE_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
Primary somatosensory area, mouth, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07178
BRD-K97624648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9602
Perturb_3698_KD_FTO_SRP226373	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.7232
Mesenteric artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.859
BRD-K99545815_PF-562271_MCF10A_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Catecholaminergic polymorphic ventricular tachycardia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.327
BRD-K44152881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84394
HLA-DQA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00471831
KCNH7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00740352
TBCK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.005744
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2232
Sinoatrial node disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
Prostate adenocarcinoma_PRAD_TCGA-KC-A4BR-01A-32R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4786-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
amygdaloid complex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.51976
CRCGN013_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.54138
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0392
BRD-K21672174_Ro 28-1675 ?_MCF7_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE213588_8_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor-sensory cortex (samples)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.65441
CGREF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92742
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1823
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31357
J82	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45932
AR	ChEA Transcription Factor Targets	1.0	null
DUSP1_KO_GDS1606_775_mouse_Spleens	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28117
SNX18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43547
substrate-specific channel activity	GO Molecular Function Annotations 2015	1.0	null
NEK8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00542761
regulation of heart rate by cardiac conduction	GO Biological Process Annotations 2025	1.0	null
RAB12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38822
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
ZNF354B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55048
ISL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.7749
POU1F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74068
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48128
BRD-K60866521_idelalisib_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Isl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2943
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.957204
BAK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551348
GTEX-TMMY-1726-SM-4DXTD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2955
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07812
parietal cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06433
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TCEAL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58548
PPIP5K2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40207
olfactory tubercle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3133
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28996
H3K36me3_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.882377
Perturb_539_OE_EWS_SRP168620	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.87415
Perturb_4303_KO_Serpine1_SRP179032	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.54117
Chlorhexidine (diacetate)_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0184229
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-1268b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Sick sinus syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
GTEX-QV31-0726-SM-3GAEG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04657
TAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48784
U-343MG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.768
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13378
PMC7655645__F3	PFOCR Pathway Figure Associations 2023	1.0	null
CRX-20693478-RETINA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-Q2AG-2826-SM-2HMJQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8319
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-regulation_of_membrane_potential_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K91506006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1272
STBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78429
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14542
MNDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08121
regulation of delayed rectifier potassium channel activity	GO Biological Process Annotations 2023	1.0	null
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MPP89	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51087
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TP53	ChEA Transcription Factor Targets	1.0	null
CHD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4621
AEBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00501975
PDCD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.0363
hypertrophic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.460129
KLF1-20508144-FETAL-LIVER-ERYTHROID-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
FOXM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00470381
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01648
SYT12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97421
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7888-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K60219430_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r8 portion of ambiguous motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17539
GSE176093_2_v_3_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Magnocellular reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08219
PIAS1-25552417-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
ZBED2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4256
ZNF160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13897
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF391	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29373
GTEX-U8T8-0326-SM-3DB93	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03067
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.960034
BRD-K61431055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07946
BRD-K65183353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38367
Perturb_11576_KO_Zip8_SRP344283	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.625
SLC30A8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00740967
BRD-K54386075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19157
cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K85670329_NCGC00180992-01_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PRPF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83739
BRD-K03546460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15903
primary motor cortex (area M1, area 4)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.46683
Heart conduction disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.129
Rectum adenocarcinoma_READ_TCGA-AF-2687-01A-02R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A58767537_afatinib_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RIPK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00531691
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22367
parafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.961633
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.052245
19096012-TableS5	GeneSigDB Published Gene Signatures	1.0	null
PUS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40058
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE142210_4_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1438
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.943892
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3963
Intercalated amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42094
H2AB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14457
ANG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04961
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943583
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927826
ATP5F1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00377219
Perturb_11713_KO_Kpna3_ERP009054	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K64890080_BI-2536_HA1E_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abamectin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58892
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85318
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.29536
HUH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.63809
BRD-K88573743_A443654_BT20_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE133213_11_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
periventricular stratum of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20991
CRCGN012_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28512
Brugada syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.068
NRTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38062
potassium ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE127916_1_v_2_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
Substantia nigra, reticular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17539
intermediate stratum of r3Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06833
GSE221327_5_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23533429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04196
GTSE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.454
long qt syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.13585
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K23440419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3897
OLIG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32195
GSE143944_2_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08509
GTEX-RU1J-0526-SM-46MUT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.882199
DT-061_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0136584
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30779
ACSL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00492878
PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
raphe nuclei of medulla	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.966285
BRD-K10893370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14901
GTEX-OHPM-1826-SM-2YUNF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03507
ELOVL7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00517172
GSE213588_9_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
OGFRL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61361
BRD-A24396574_celastrol_LNCAP_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
B3GALNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25098
BACH1_02_188	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.45943
TOP2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00627553
LARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30735
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
hepg2	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
GSE164508_1_v_0_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CALD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52371
NEFM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00550161
GTEX-PWN1-2026-SM-48TD9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.50505
ACE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00644572
PMC6639357-41467_2019_11150_MOESM4_ESM.xlsx-SupTab1_Activated_genes_diffex-Supplementary_Data_1_Fold_change_and_p-value_of_all_activated_protein_coding_genes_upon_DNMT1-KO_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
A1207	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
cuneus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.968796
GSE133070_3_v_1_prss1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZFHX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53867
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16856
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.409
GTEX-S32W-1126-SM-4AD5V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979684
GTEX-TKQ2-1026-SM-33HB7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69555
GSE227592_0_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K79me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CD24_Reduced expression_GDS1392_93_human_Bone Marrow	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08586
Mean platelet volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.1
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-U51024685_HG-6-64-01_SKBR3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PWN1-1826-SM-2S1PE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04363
kidney	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K78643409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40281
BRD-K49075727_nintedanib_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K82578220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11025
GSE229671,GSE229673_2_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24796
Supplemental somatosensory area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.77248
GTEX-T5JC-0526-SM-32PM7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847834
TP53	JASPAR Predicted Transcription Factor Targets	1.0	null
12734205-TableS2	GeneSigDB Published Gene Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16741
RPRM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28376
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9131
BRD-K89524688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43258
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928411
UBFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79006
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51805
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.33287
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Prostate adenocarcinoma_PRAD_TCGA-G9-6348-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KMO	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00693762
BRD-K19181733_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K96076993_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NANP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0558
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.08482
IPPK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00543906
FCRL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585369
hsa-miR-195	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
CREB3L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00828501
BRD-K90004516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40582
GTEX-XXEK-2526-SM-4BRUR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861509
NSMF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15958
BRD-A19633847_PERHEXILINE MALEATE_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BSG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49871
neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.09691
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ion channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.749
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01161
BRD-K94544211_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K21466747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09094
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0778
BRD-K46949676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.71391
X	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.903282
MAX	JASPAR Predicted Transcription Factor Targets	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01421
dorsolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.45751
BRD-K08417745_SID 26681509_HT115_6.0_h_88.8_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.7088
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12751
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
B3GALT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22986
BRD-A19500257_geldanamycin_A375_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE122215,GSE122217_0_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LRATD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82559
H3K9ac_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4776-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
electrophysiological	GeneRIF Biological Term Annotations	1.0	null
H3K9me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K99964838_S1014_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE236262_2_v_1_trim28_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_473_OE_ARAF_SRP259289	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-16.7277
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CBR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55192
LRP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2312
PMC12209767-bcd-25-0099_supplementary_table_s2_suppst2.xlsx-C_DEGs_RNA-seq-Supplementary_table_S2C_List_of_differentially_expressed_genes_in_IGHUND_vs_IGH_GCB_MB2_DE_DLBCL_HGBCL-DH-BCL2_-BCL6_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mkcne4	GeneRIF Biological Term Annotations	1.0	null
MRTFA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00579152
TGM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00510112
MCHR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00604556
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24796
BRD-K55187425_ON-01910_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TP53-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K81644801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05193
oocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.813144
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.164359
PRUNE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37537
BRD-K53417444_OTSSP167_HCC515_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1768
PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.25792
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-K1-A42X-02A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.417
DTX3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89652
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AJUBA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00649749
GSE196117_1_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CD81	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00452459
KCNA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00585059
GSE216043_10_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HEY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1699
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
BRD-K80239721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03752
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4799-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer plexiform zone in extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.859829
lateral superior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10742
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.987
YTHDF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65009
Lung squamous cell carcinoma_LUSC_TCGA-22-4594-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.4387
TCCSUP	CCLE Cell Line Gene Expression Profiles	-1.0	-2.55845
physically	GeneRIF Biological Term Annotations	1.0	null
PDE4D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00808761
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
BRD-K28753508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45192
MZ in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.871172
GTEX-XAJ8-0326-SM-47JYI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16092
TM6SF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00559069
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34031
STRN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87622
HS751T	CCLE Cell Line Gene Expression Profiles	1.0	1.34731
salivarygland_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.20255
ILRUN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15494
Allantoin_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0114708
P30-OHK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_6484_OE_NEUROG2_SRP292702	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.29532
r8 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10347
TFE3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5454
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SG in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29787
BRD-K49371609_528116.cdx_HT29_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PDE4C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00703475
ZNF687	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84001
SOX9-24532713-HFSC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27671601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51809
Perturb_17230_KD_CCM2_SRP389914	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE164874_5_v_7_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242199_6_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ASIC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0086749
BRD-K02839126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57653
GJA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18815
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.7766
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.29257
BRD-K11504463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4072
GSE142210_4_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
SBDS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00558362
nonsynonymous	GeneRIF Biological Term Annotations	1.0	null
PMC7825356-8844261.f3.docx-48-EN2_EN2	Rummagene Transcription Factor Associations 2026	1.0	null
ATM_knockout_75_GSE23116	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.80168
FAM200A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60822
EDEM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56139
Lung adenocarcinoma_LUAD_TCGA-MP-A5C7-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.974173
Adrenocortical carcinoma_ACC_TCGA-OR-A5J9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE198165,GSE198166_7_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K19540840_saracatinib_HME1_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.971
BRD-K47794327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92042
PMC11604281-7680736.f3.pdf-4-BATF2_BATF2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K36111748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18838
BRD-K63645840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25122
hsa-miR-4673	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
p2 portion of the substantia nigra pars reticulata	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18558
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
NOS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69046
PancreaticIslet	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.16312
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18725
FOXO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09267
CJUN-26792858-CHIP-SEQ-BT549-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC10282096-41467_2023_39038_MOESM4_ESM.xlsx-All_genes_Upregulated-ENSG00000177426_TGIF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RU72-1226-SM-2TF6N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883104
EEF2K	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502498
EMC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01599
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
AICD_Induced  expression / Over-expression_GDS1979_288_human_SHEP-SF neuroblastoma	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K9me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.37846
BRD-K40738002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28024
OCT4-21477851-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
KLF1-20508144-FETAL-LIVER-ERYTHROID-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
HEXB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.3704
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.3505
STAT4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00502559
BRD-K51760683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84595
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.644884
cefapirin-2730	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ADCYAP1R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16251
A-CA-04-2009(H1N1)_Day1_22532695_GSE36328	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.34934
Hypohidrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.285
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00716
BRD-K78676275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31704
BRD-K79090631_CGP-60474_HCC515_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K27945483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03573
GTEX-PSDG-1526-SM-48TCY	GTEx Tissue Sample Gene Expression Profiles	1.0	3.16334
DLG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00379277
BRD-K03205303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83288
BRD-K63058274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35534
lateral nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.924231
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040889
GTEX-PW2O-1926-SM-2S1OB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54105
BRD-K61505971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30806
GSE168596_1_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BC3C	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36432
CDAN1_02_197	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.80735
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.980711
TE9	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.55807
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.09851
NPY5R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00676768
STRBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11767
hsa-miR-513a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
GRK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00673631
Cation channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.06573
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.929211
Primary motor area, Layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19886
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PHAX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26234
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.32555
PCGF2-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NFI-21473784-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CHI3L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00791851
SUZ12-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RBM27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29087
BRD-K73775927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68026
PSAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70945
Orbital area, lateral part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05171
BRD-K72636697_QL-X-138_HME1_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H2BK20ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE142210_3_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-VUSG-2826-SM-4KKZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30593
GTEX-OXRK-0326-SM-3NB3R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861466
ZNF665	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58943
GTEX-SE5C-0326-SM-4BRWX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08228
disease of cellular proliferation	GWASdb SNP-Disease Associations	1.0	0.111443
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
CLMP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28132
monovalent inorganic cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K28120222_Prestw-550_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SOX9-26525672-CHIP-SEQ-LIMBBUDS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-T2YK-0326-SM-4DM7D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914957
hsa-miR-16	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
GTEX-R53T-0826-SM-48FCP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35064
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7925-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARRDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01839
Weight Loss	CTD Gene-Disease Associations	1.0	1.28858
GSE168797_1_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_15039_KO_Pdgfd_SRP321475	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
RBPJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85455
GSE150669_0_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SMAD4-21799915-A2780-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K03063480_PF-477736_SKBR3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4351-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.83747
BRD-K14671808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53112
BRD-K92791036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31676
PMC8905236-mmc2.xlsx-Table_S10-Table_S10_Differentially_regulated_genes_in_SPI1_high_vs_low_group_in_CGGA_GBM_dataset_SPI1	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18509
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902712
KLF1	ChEA Transcription Factor Targets	1.0	null
BRD-K38615104_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE119345_0_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
VZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.960288
Rhinitis, Allergic, Perennial	HuGE Navigator Gene-Phenotype Associations	1.0	null
membrane repolarization	GO Biological Process Annotations 2023	1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KLF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09207
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8589
JPH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21551
LOVO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
WM-239 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.007
BRD-K24070365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79242
GSE213219_0_v_3_st3gal3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
functions	GeneRIF Biological Term Annotations	1.0	null
BRD-K35259368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05856
primary auditory cortex (core)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.91297
NCIH292	CCLE Cell Line Gene Expression Profiles	-1.0	-2.73657
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07711
PTAFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00523919
Perturb_3351_KO_Tsc2_SRP227934	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RASGRP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00622385
Perturb_16829_KO_Ras/Apc_SRP306767	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.152
KCNG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58748
urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21542
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0074
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
GSE164874_5_v_8_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Superior vena cava	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.512
Tazarotene_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00698664
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902712
modulation	GeneRIF Biological Term Annotations	1.0	null
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SKHEP1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59885
BRD-K02708799_GSK-1059615_HME1_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CARD9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00881165
SIRPD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00595348
GBGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12307
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K03902845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49446
BRD-K38118226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26391
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
18801183-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GSE233679_5_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.948772
IFNG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0063932
POMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39897
CRCGN015_MCF10A_48H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7937
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43507
DNAJC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21882
MEF2A-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Renal artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.139
GSE178255_3_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K02822062_CT-200783_MDST8_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HUS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490114
BRD-A45498368_WYE-125132_HME1_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Sarcoma_SARC_TCGA-IS-A3K8-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-R53T-1226-SM-48FCT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.491
hsa-miR-3908	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K39944607_32937_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZSWIM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57121
gallbladder_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.11704
IFRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30711
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05519
dexamethasone_homo sapiens_gpl6480_gds3946	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ITPRIP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608275
TE14	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46903
LILRB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554499
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28614
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
Minodronic acid_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0170054
BRD-K68401280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66985
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4845-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.918504
muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.092837
CAL851	CCLE Cell Line Gene Expression Profiles	-1.0	-1.61048
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
MOV10L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36432
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5177-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TGFBI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66591
BRD-A55594068_VINBLASTINE SULFATE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RMC-6236_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0118671
GTEX-Q2AH-2026-SM-2S1PX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41208
SNU475	CCLE Cell Line Gene Expression Profiles	1.0	1.44528
CAMTA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69885
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.2834
RETSAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97062
NDUFS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00526197
NPFFR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00729573
H3K27me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74402642_Chemistry 2804_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YN-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02299361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75508
GSE140997_4_v_3_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K49075727_nintedanib_HME1_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
suprachiasmatic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58903
PCSK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98768
ADCY3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65374
Brain Lower Grade Glioma_LGG_TCGA-DU-6406-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K71141540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28456
MK-8353_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0331047
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.853208
C2BBE1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.56237
TRIB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03175
496100412_FWM_possible Alzheimer's disease_TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.33506
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16322
GTEX-OOBJ-0226-SM-2YUMM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0583
BRD-A19037878_trichostatin A_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TSEN54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29179
BRD-K63545954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02082
NKX2-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8876
BRD-K49865102_PD-0325901_HEPG2_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TRIML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63116
HES6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8791
PMC8901773-41598_2022_7986_MOESM3_ESM.xls-PGJ2_vs_LPS-Gene_symbol_ENSEMBL_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
RDM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59999
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.453
BRD-K65050353_5636194_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
B3GNT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44969
NUGC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.882377
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11015
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916745
GSE223287,GSE223290_2_v_4_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K78431006_crizotinib_MCF7_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TMEM158	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01151
IKZF3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552575
EBF1-22473956-LYMPHODE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ANO6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.007625
showed	GeneRIF Biological Term Annotations	1.0	null
BRD-K02133388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15141
ZNF280C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16951
MCRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31524
TLR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30346
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20557
MTAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39876
dorsolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04314
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Atrial Fibrillation	DisGeNET Gene-Disease Associations	1.0	null
BRD-K05653692_DL-PDMP_H1299_6.0_h_64.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A76A-01A-51R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.816099
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IKZF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47053
ABCD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00780004
GTEX-O5YV-0426-SM-3LK66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50311
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
voltage	GeneRIF Biological Term Annotations	1.0	null
GSE169571_5_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FUCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7411
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
Uterus-vascular associated smooth muscle cell	Tabula Sapiens Gene-Cell Associations	1.0	1.95455
BRD-K77908580_entinostat_HEPG2_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K62624148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05421
20436685-ST4-2	GeneSigDB Published Gene Signatures	1.0	null
metal ion transport	GO Biological Process Annotations 2015	1.0	null
BRD-K26472648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15455
APOD_KO_GDS3913_487_mouse_Cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.50453
PFKL_OE_GDS1980_203_mouse_dermal fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE261563_7_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.542
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28465
BRD-K13130949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30469
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FU-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LMNB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00662251
FAM124A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82174
GSE138001_2_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.12124
BRD-K14246348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2607
MTFR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65547
nucleus sagulum, deep part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00223
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	GO Molecular Function Annotations 2023	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7300-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal lateral geniculate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.962547
abnormality of the face	GWASdb SNP-Phenotype Associations	1.0	0.142134
BRD-K25931705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46816
GSE133213_6_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145639_7_v_2_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K68858233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46124
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K44494409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07271
BRD-K92428232_GSK-461364_HCC515_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LCAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28264
EZH2	ENCODE Transcription Factor Targets	1.0	null
rhinitis	GeneRIF Biological Term Annotations	1.0	null
GSE239844_11_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE101239_3_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A24396574_celastrol_LNCAP_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Aorta thoracica smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.053
OLIG2-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ATP2A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00551546
NCIH526	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52431
Arid5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.4003
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
DPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98231
thp1	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
BRD-K59184148_SB-216763_PC3_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K86003836_flubendazole_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K67013324_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K68087668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0654
Corpus cavernosum smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.206
GSE220520_5_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Adverse Event Associated With Cardiac Arrhythmia	DisGeNET Gene-Phenotype Associations	1.0	null
Sinus node	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.293
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6583
molecular_function	GO Molecular Function Annotations 2015	1.0	null
voltage-gated potassium channel activity	GO Molecular Function Annotations 2023	1.0	null
FDFT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00359592
BRD-K12710356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63009
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.76666
Rucaparib (phosphate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0178964
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
PRDM14-20953172-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
superficial stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32645
GSE214823,GSE214824_6_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Polygenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.688
GSE114992,GSE114993_0_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pulmonary vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.7
HS863T	CCLE Cell Line Gene Expression Profiles	1.0	1.6927
MMUT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83024
SAMD4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23147
NDUFA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00476639
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18509
Primary somatosensory area, unassigned, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11666
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23637
BRD-A19500257_geldanamycin_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SMAD1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RAB31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74313
MX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10214
SIDT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25938
SLAMF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0061944
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
BRD-K90019187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08973
GSE188458_2_v_3_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A7r5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.194
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.28518
GTEX-VUSG-0726-SM-3GIK1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878273
GSE124471,GSE124488_2_v_3_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39421
UBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25092
BRD-K36363294_I-BET151_HA1E_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877602
BRD-K81522184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24151
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE87615_2_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K91620436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.5587
BRD-K24132293_PIPLARTINE_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NR1H4::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3656
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
Memory Performance	DisGeNET Gene-Phenotype Associations	1.0	null
HPRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07963
BRD-K43387144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39369
ESR1-22446102-UTERI-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-QV44-2226-SM-447A3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41848
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.32044
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01946
MS4A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00614502
Immunological synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.082
G protein-coupled receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.0
CRCGN012_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3747
ARFGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9055
endometrium_8b	HPA Tissue Sample Gene Expression Profiles	1.0	1.15263
Kidney renal clear cell carcinoma_KIRC_TCGA-EU-5904-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE166944_3_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CSNK2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00548662
PXMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1449
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
terminal hypothalamus (rostral hypothalamus)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07677
Uterus-myometrial cell	Tabula Sapiens Gene-Cell Associations	1.0	0.209564
BRD-K87213231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00802
GFUS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30239
Volasertib_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0361412
BRD-K88510285_B675700.cdx_SKLU1_6.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
periventricular stratum of r8Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37271
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	3.42224
cerebral lobe	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE123689_1_v_0_cbx8_human	RummaGEO Gene Perturbation Signatures	1.0	null
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	GO Molecular Function Annotations 2025	1.0	null
acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.052537
BRD-A55722685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14274
GSE153124_4_v_0_dsg2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.911195
BRD-K47804666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43283
SNX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56141
ACBD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73878
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.875779
GNB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71648
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
leukemia	GWASdb SNP-Phenotype Associations	1.0	0.306729
GALK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00693277
heart	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.725685
TRAPPC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34575
RPSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32493
ZNF251	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48074
G402	CCLE Cell Line Gene CNV Profiles	1.0	1.62063
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5887-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S95S-1626-SM-2XCDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03981
GTEX-WHWD-2426-SM-3LK6S	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01756
BRD-K02708799_GSK-1059615_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.056341
CTDSP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39836
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11948
hsa-miR-497	TargetScan Predicted Conserved microRNA Targets	1.0	0.03694
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
adrenosterone-3107	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
region	GeneRIF Biological Term Annotations	1.0	null
NCIH2405	CCLE Cell Line Gene CNV Profiles	1.0	1.77385
anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05127
PRKCA	Pathway Commons Protein-Protein Interactions	1.0	null
Intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16741
autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.35082
PRRC2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60985
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149124,GSE149128_3_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cho cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.179999
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
perimammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20991
halfmaximal	GeneRIF Biological Term Annotations	1.0	null
Nucleus of the solitary tract, gelatinous part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25043
EBF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71149
FZD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86187
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51232
GORAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04719
GSE184892_6_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
TRPV3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00648847
BRD-K38189984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1819
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-2q37_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZC3H12C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00629153
BRD-K08527280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72577
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
BRD-K74486924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19959
METTL2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3098
BRD-K84949119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34154
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18234
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of SeDg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25177
ABCC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564819
GSE169697,GSE169725_0_v_5_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.90603
thymus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.868011
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TCTA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00446962
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Sarcoma_SARC_TCGA-K1-A42X-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RABL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00363
BRD-K72636697_QL-X-138_PC3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882765
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0632
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.29595
BRD-K11433244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27167
BRD-K21064560_PALDA_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_MCF10A.TP53.M_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01065
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1912
Brain Lower Grade Glioma_LGG_TCGA-S9-A6UA-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K31248348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01387
Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37156
GSE142210_3_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
spleen	HPA Tissue Protein Expression Profiles	-1.0	-0.769949
TNFRSF10A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98354
ISX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81371
Lung squamous cell carcinoma_LUSC_TCGA-66-2754-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2141
BRD-K13074426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30852
KLHL25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42296
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4974-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K56837922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2885
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.13179
PMC4141782-pone.0105522.s005.xls-SMAD5-Unnamed_1_SMAD5	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8C_Het1A-HNF4A_2d_5x_closed-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.52166
TGFB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563308
dorsolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.976745
SUM1315MO2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.685499
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.03378
BRD-K38946705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40747
Integral component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
HES3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64922
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975756
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46957
Sarcoma_SARC_TCGA-WK-A8XY-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4345-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.88601
DHX30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00049
superficial stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12732
RT112	Achilles Cell Line Gene Essentiality Profiles	1.0	2.39388
ppard_23093780_pancreatic_beta_cells_lof_mouse_gpl1261_gds4320	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.027319
lhx8_18509161_newborn_ovary_lof_mouse_gpl1261_gds3254	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.234482
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ITGB4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00856551
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35861
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4C7-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.62919
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.10481
LTB4R2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00666906
GSE150072,GSE169209_6_v_11_qser1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
USF1_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76694128_DCC-2036_A375_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PTPRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04314
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.2059
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
hippocampus (hippocampal formation)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.856602
IGF2BP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94152
NLGN4X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90528
ARRB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57688
Arterial smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.297
OVTOKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5998
REST_PFSK-1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LRRC75B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.46845
NOP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03072
BRD-A19500257_geldanamycin_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE142210_2_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-3064-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
BRD-K61924932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.61023
NECAB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61296
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Appendicular lean mass	GWAS Catalog SNP-Phenotype Associations 2025	1.0	3.90969
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-8_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
AIRE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0103499
CARD6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0090985
BRD-K83276573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00097
ZNF397	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.46937
NDUFAF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.32608
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.35846
BRD-K34604755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63925
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.989
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0569
SMARCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66486
Labial palp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.281
CGRP receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.307
SPDYE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32
ROCK_INHIBITION_GDS3944_461_mouse_Forebrain astrocytes - 2 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-8174-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COMTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66586
hsa-miR-4667-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
STKLD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0068991
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.851609
GJD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00526536
CAPNS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05712
heart	GeneRIF Biological Term Annotations	1.0	null
ARHGEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55757
interpositus (intermediate) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19155
nasopharynx carcinoma	GWASdb SNP-Disease Associations	1.0	1.10764
posteroventral (inferior) parietal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.64813
SIRPB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00562279
BRD-K79090631_CGP-60474_HT29_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K03093950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29817
BRD-K51399866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0238
FIBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36174
leukocytes	GeneRIF Biological Term Annotations	1.0	null
vascular bundle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.130504
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.898475
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29544
BRD-K41999717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0994
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-fig-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
NCF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00572504
CACTIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15517
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_2-1769_genes_are_more_than_four-fold_upregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
GAD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490118
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.882377
Cardiac Purkinje fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.966
Bicalutamide_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.010869
Brain Lower Grade Glioma_LGG_TCGA-DU-6402-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GFPT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44816
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.854425
BRD-K03063480_PF-477736_SKBR3_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ABCD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00579018
BRD-K49371609_528116.cdx_PC3_24.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A172	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.07618
BRD-K87947369_VX-680_HEC108_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
PMC9305137-PATH-256-297-s005.xlsx-CIC_associated_DE_genes_IDH1-W-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
IGROV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KLM1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.9319
PDE5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00770395
BRD-K35407043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32839
COLO741	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68389
CCDC77	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00587554
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07712
BRD-A70155556_NP-001236_VCAP_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Epi	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
C18orf54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51912
cardiovascular	GAD High Level Gene-Disease Associations	1.0	0.293278
ITGAX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00726917
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
IRF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40249
CAPAN1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6582
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vomeralnasalorgan.VMO.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.05001
CILP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00617927
GTEX-XBED-0226-SM-47JY8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11247
medial amygdala, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2277
Primary somatosensory area, lower limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19146
GSE145639_7_v_4_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0102
Fasting plasma glucose	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.61549
GTEX-UPJH-0926-SM-4IHKA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859039
Lung adenocarcinoma_LUAD_TCGA-69-8253-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K61909412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70855
BRD-K72034944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82193
BRD-A79465854_auranofin_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74954
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.971347
CCDC121	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00648956
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
JAKMIP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00665451
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
leukemia, lymphoid	GAD Gene-Disease Associations	1.0	null
PMC9396374-Table_5.XLSX-Table_S5-AR_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE87615_1_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Long QT syndrome 11	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.446
CFLAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26602
GTEX-QV44-1825-SM-447CF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885263
cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.059968
BMPR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0066808
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.830739
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883129
voltage-gated potassium channel activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-WCDI-0426-SM-4GIAL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36896
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DG-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2882-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178255_5_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary somatosensory area, barrel field, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50737
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6855
bj	HPA Cell Line Gene Expression Profiles	1.0	0.939865
BRD-K58168959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41631
CCDC181	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00568655
slows	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3BZ-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15056
hel	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-NFE2L2_V2-Ensemble_gene_ID_NFE2L2	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K78126613_MENADIONE_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE169205_0_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101239_4_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
action potential	GO Biological Process Annotations 2023	1.0	null
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.52006
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11971
r9 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39234
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FAM200B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85509
regulation of transport	GO Biological Process Annotations 2015	1.0	null
PHB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00681105
TRIM26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29411
MANEA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62891
PRKCA	Hub Proteins Protein-Protein Interactions	1.0	null
ABCA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00797312
BRD-K09144377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80632
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11866
BRD-K18190982_COT-10b_HT115_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PPARD-23208498-MDA-MB-231-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TMEM60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89422
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09846
BRD-K28694162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19628
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.2898
GSE221327_5_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CSK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41016
PPARD	ChEA Transcription Factor Targets	1.0	null
COX5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47355
chemdependency	GAD High Level Gene-Disease Associations	1.0	0.295739
VMRCRCZ	CCLE Cell Line Gene CNV Profiles	-1.0	-1.96746
SARS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519389
BRD-K06994380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01735
layer 6 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.295
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.67338
PMC9396374-Table_4.XLSX-AR_related_target_genes-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1226
i band	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.285138
abnormality of the nasopharynx	GWASdb SNP-Phenotype Associations	1.0	0.969142
MITF	ChEA Transcription Factor Targets	1.0	null
GSE252864_0_v_3_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00619326
GSE207514,GSE207515_1_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCIRG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00600397
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-322-KLF6_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
ACTR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78469
KCNAB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08147
potassium ion transport	GO Biological Process Annotations 2015	1.0	null
BRD-A19500257_geldanamycin_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29076
LN340	CCLE Cell Line Gene CNV Profiles	1.0	1.84712
hsa-miR-15a	TargetScan Predicted Conserved microRNA Targets	1.0	0.034317
SOX6-21985497-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.98619
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22141
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.936443
BRD-K54861624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01372
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
PMC11426526-ppat.1012555.s011.xlsx-DEG_MDDC_Jurkat_LPS_vs_MDDC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CBX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55518
KCNJ5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00658249
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14148
DUT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52515
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.30727
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
ZFHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89328
episupraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26146
Perturb_17580_KO_Rif1_SRP348198	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
hsa-miR-1268	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
ASPHD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00566719
Perindopril (erbumine)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0208653
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.77488
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inorganic cation transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Perturb_17232_KD_ITGB1BP1_SRP389914	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-19.0458
Rectum adenocarcinoma_READ_TCGA-DC-6156-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.05423
PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
seed	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063473
RRM2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8413
GTEX-S341-1026-SM-4AD71	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44127
G-402	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.7052
eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056481
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
alar part of terminal hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03784
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199081_0_v_1_insr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A85860691_chaetocin_PC3_24.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K45172622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84358
Perturb_5930_KD_MBD3_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.65977
TSEN15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22483
NFYB	ENCODE Transcription Factor Targets	1.0	null
chr2_223110718_G_T_b38	GTEx eQTL 2025	1.0	1.25468
TNP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31383
TGIF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0519
IL31	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00647843
HJURP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30918
hsa-miR-4313	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.43973
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.67013
hsa-miR-4779	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
dorsomedial preoptic area, superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.12188
GRPEL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06298
DDX59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35442
CRCGN008_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2239
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.31555
XPO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72455
VCAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15045
BRD-K23593468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16894
nucleus of Darkschewitsch, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.884179
BRD-K87193132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3196
PMC8481886-Table_1.xlsx-A_subsets-UC_MSC_adipose_tissue_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CACO-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45652
GSE180813,GSE180815_1_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mesothelioma_MESO_TCGA-LK-A4O6-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MT-1426-SM-3LK5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72651
lateral ventricle	HPA Tissue Protein Expression Profiles	-1.0	-1.41887
BRD-K57155690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15615
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.982033
GTEX-V955-2626-SM-3NM9F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65363
SLC39A8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00681561
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
PMC4082364-supp_ddu111_ddu111supp_table14.xls-Tabelle1-Table_S14_comparison_MSC_WT1Wilms3_-_top_100_genes_down-regulated_vs_wtWT1_-_top_100_down-regulated_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE207514,GSE207515_0_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RERF-LC-FM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.490229
ULK-101_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0126853
hsa-miR-3688-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
BRD-K79090631_CGP-60474_MCF10A_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4722-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
FOXA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15058
r9 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.35891
BRD-K38189757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80609
GSE184892_7_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K41538715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.25871
BRD-A80960055_3203_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Primary motor area, Layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94491
SMARCA4	ChEA Transcription Factor Targets	1.0	null
GTEX-S4Z8-2026-SM-3K2A9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28232
SOX2-22085726-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K60762818_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TADA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83335
interstitial nucleus of the posterior limb of the anterior commissure	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51819
BRD-K88378636_withaferin-a_MDAMB231_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE151829,GSE151831_5_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pacemaker cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.359
daudi	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
HASPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68982
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EC-01A-21R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAGEE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26807
potassium	GeneRIF Biological Term Annotations	1.0	null
PUSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40921
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4700-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859003
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.21883
RD	CCLE Cell Line Gene CNV Profiles	1.0	2.47563
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Leaflet of membrane bilayer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.851
FAM162A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3132
GTEX-UPIC-0926-SM-4IHLV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850986
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
Belumosudil_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0257802
GSE211126_1_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12963
FBN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00500259
BRD-K11874023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09518
AP2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39062
ME1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.51888
MSTN_KO_GDS3637_439_mouse_muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BCAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00806211
C14orf93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86564
BRD-K93480852_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.843734
GSE195663_0_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
intermediate stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19241
ZNF418	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.95233
Anteromedial visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.46071
CADOES1	CCLE Cell Line Gene Expression Profiles	1.0	3.40874
E2F1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PLA2G6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00539882
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K60834597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13913
SLC25A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76046
BRD-A45498368_WYE-125132_HME1_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Amygdala	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K51454562_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE242199_9_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
APOBEC3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00729718
GSE240344_1_v_0_uxs1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15946
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
ICAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89788
GTEX-T5JW-1526-SM-4DM5E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42193
dorsolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.83425
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.41887
FFAR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00657804
BRD-K36517203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4707
HCC1833	CCLE Cell Line Gene Expression Profiles	1.0	2.19942
sinus node	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.606916
CEBPB-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
orbital frontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09192
PRKAG3_KO_GDS1398_703_mouse_gastrocnemicus muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
hsa-miR-665	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
C-Reactive Protein Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
PMC6167382-41467_2018_6258_MOESM4_ESM.xlsx-TEAD-associated_GSC-Specific_UP-Nearest_Ensembl_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
NDC80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18948
GSE243199_1_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.114203
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ATF3_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Phase 3 - rapid repolarisation	Reactome Pathways 2024	1.0	null
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.58317
all	GWASdb SNP-Phenotype Associations	1.0	0.03201
CHRNA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0086037
primary motor-sensory cortex (samples)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.72951
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-11A-13R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Diammonium Glycyrrhizinate_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0200995
Lung adenocarcinoma_LUAD_TCGA-91-6849-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K48195722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15766
BRD-K85977749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79129
membrane region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.003506
CDC7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00685249
SMAD4-21799915-A2780-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
EIF4G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13919
Perturb_9221_KO_Scgn_SRP396836	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.07449
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K59221664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05263
sodium:potassium-exchanging ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.756
GSE143316_0_v_6_somatostatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PLTP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00656332
Adductor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.019
HSF1_KD_GDS1733_751_human_HeLa cells - 0.5 Hour by siHSF1_1	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054207
GTEX-SJXC-0226-SM-2XCDU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837989
DNAAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32494
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32471
BRD-K02334683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38174
CHO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.471
hyperthyroidism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.194865
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.67909
15361855-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24783
ATP1B2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00941815
GTEX-Q2AG-0526-SM-2S1PW	GTEx Tissue Sample Gene Expression Profiles	1.0	2.33832
GTEX-W5X1-0006-SM-3GIJZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
BRD-K79090631_CGP-60474_HCC515_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K61943321	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27556
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.567585
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969816
GSE130956_2_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
HER2_KO_GDS4056_567_human_breast biopsies	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
hsa-miR-3611	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
hippocampus (hippocampal formation)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.93787
LDAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07479
SHBG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00580547
ATP5F1D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585928
BRD-K78867378_mw-A1-12_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
interacts	GeneRIF Biological Term Annotations	1.0	null
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4957
P31FUJ	CCLE Cell Line Gene CNV Profiles	-1.0	-2.36947
heart conduction disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.812642
IHH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00543875
HACL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30561
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.53489
BRD-A94377914_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5259
BRD-K50162138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39689
PMC12122724-41467_2025_60028_MOESM6_ESM.xls-Supplementary_Table_4_Marker_g-Supplementary_Table_4_Marker_genes_of_six_TPIT_tumor_subtypes_TBX19	Rummagene Transcription Factor Associations 2026	1.0	null
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0536
ARHGAP25	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00461955
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0276
GPR65	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00774524
Urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.59031
PMC7075910__F7	PFOCR Pathway Figure Associations 2023	1.0	null
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.870911
MPZL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88491
KCTD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07083
NINJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87562
A-CA-04-2009(H1N1)_12Hour_None_GSE37571	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.45886
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PADI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00577026
PGR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5701
BRD-K37687095_AZD-8330_MDAMB231_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OLFML2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90726
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.956498
layer 1 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.87088
BRD-K84118789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49453
sublayer 6b of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2159
parasubicular cortex (parasubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.841823
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.869897
GSE125153_2_v_3_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_13_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
PPP1R1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19082
ZNF41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99376
ADAM19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00588953
FLT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0106445
GSE195663_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.897486
RBM4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79558
r4 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21414
WWTR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00405065
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.59202
nasal cavity disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.700321
GTEX-PWCY-2126-SM-48TEC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9644
PRKAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97211
wm115	HPA Cell Line Gene Expression Profiles	1.0	0.849047
SLFN12L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0070679
BRD-A45498368_WYE-125132_HME1_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE162892_4_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11601_KD_ABCD4_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.26294
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-648	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K54233340_Dorsomorphin dihydrochloride_NCIH2073_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K59856141	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3445
BRD-K72709319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0286
Stria vascularis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.987
spanning component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.598538
Infection by Yersinia enterocolitica_macrophage_GSE2973	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.56725
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XM-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228125_2_v_1_ptafr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84368
Flotillin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.872
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37752
BRD-K13679727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1994
BRD-K90697692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44186
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
USF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7322
r3 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2696
GTEX-QCQG-0726-SM-48U1Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975454
ACP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06333
PMC10800016-table_s5_20230913_ddad186.xlsx-FvsC_-_DUX4_I-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3M_Peaks_YAP1MAMLD1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
MET_knockout_247_GDS3148	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.84759
Adrenocortical carcinoma_ACC_TCGA-OR-A5JX-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.79563
CL-34	COSMIC Cell Line Gene Mutation Profiles	1.0	null
inorganic ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
ventral tegmental area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12913
respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.103937
BRD-K37151525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07382
SG in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10297
domains	GeneRIF Biological Term Annotations	1.0	null
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16233
BRD-A19037878_trichostatin A_EFO27_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC7445411-CPR-53-e12862-s006.xlsx-Sheet1-Supplementary_Table_S4_Gene_expression_profiling_of_NT-MSC_and_III-MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
anteroventral periventricular preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38439
LY6G6F	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00844137
BRD-K88573743_A443654_BT20_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
CRCGN014_HEPG2_24H:B05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04114
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29907
SLC25A20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00622795
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75536
N4BP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29388
hsa-miR-4685-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-K26321439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13135
GSE239844_11_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Intercalated disc	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.155
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.1054
CHAGOK1	CCLE Cell Line Gene CNV Profiles	1.0	1.56965
BRD-K61323504_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Basal ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-RWS6-1026-SM-47JXD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1723
ventrolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26869
CRCGN009_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34733
ACTB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00435083
KLF4-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HRH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00802493
FGD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80797
BRD-K53417444_OTSSP167_HCC515_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FBXW2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65658
GTEX-WEY5-1326-SM-3GILS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956262
SNAP29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05201
Infertility, Female	CTD Gene-Disease Associations	1.0	1.58421
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.54902
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GT-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Plant hair	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.579
PMC12179525-mmc1.xlsx-Group_HNF4A_vs_Null_sign-Supplemental_Table_S1_Differentially_expressed_genes_in_HNF4A-transduced_cells_vs_Null_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
Somatosensory areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08452
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.50318
BRD-K27973265	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40901
Perturb_7701_KD_Spt6_SRP132004	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.62579
GSE221327_10_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SW948	CCLE Cell Line Gene CNV Profiles	1.0	1.34183
BRD-K13146924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66497
H3C15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49622
496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.35088
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.892135
r3 part of ventral lateral lemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29061
DDX53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27041
GSE195663_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210951_1_v_0_islr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CSNK1G3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56305
irinotecan_rattus norvegicus_gpl1355_gds3466	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
184B5	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.934373
PLCG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11083
Brain Lower Grade Glioma_LGG_TCGA-HT-A61C-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hematologic cancer	GWASdb SNP-Disease Associations	1.0	0.250475
BRD-K64800655_PHA-793887_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
required	GeneRIF Biological Term Annotations	1.0	null
GTEX-OHPK-2026-SM-3MJH7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955874
Acute Myeloid Leukemia_LAML_TCGA-AB-2821-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-8395-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
smooth muscle	HPA Tissue Gene Expression Profiles	1.0	1.588
B3GNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7156
TMEM59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09076
smoothmuscle_8c	HPA Tissue Sample Gene Expression Profiles	1.0	1.63312
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.975117
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.3809
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SLC22A23	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00570572
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.16773
MPHOSPH6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00684005
CRCGN014_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07725
LIG4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00840125
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42168
Limbic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
layer 5 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0892
GTEX-S33H-2426-SM-2XCB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42235
LB-100_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0219616
Sarcoma_SARC_TCGA-RN-A68Q-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
vestibular nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14246
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
RUNX1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
COA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42594
FOXD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27199
regulation of transmembrane transport	GO Biological Process Annotations 2015	1.0	null
superficial stratum of r3Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26146
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-RU1J-1926-SM-2TF6S	GTEx Tissue Sample Gene Expression Profiles	1.0	2.22025
CD320	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00556158
BRD-K61595867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27012
GSE70935_2_v_4_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18521
VIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10962
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.31
corticoid layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36546
GTEX-R53T-2026-SM-3GIJF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58534
CENPW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82464
mantle zone of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18359
NCOA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00517167
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877576
PMC9539848-PATH-257-579-s008.xlsx-NCOA2_vs_NCOA2-ctrl-geneSymbol_NCOA2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3328
Perturb_8671_KD_PKP2_SRP035559	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
kcne2	GeneRIF Biological Term Annotations	1.0	null
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.960034
muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.095263
GSE166914_1_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K67950754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03101
Intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.066
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4458
HS6ST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94448
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2139
EP300-20729851-FORBRAIN_MIDBRAIN_LIMB_HEART-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.428783
Hypertrophy	CTD Gene-Disease Associations	1.0	1.31327
DHFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00370156
atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.52635
ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50142
NR3C1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A7J1-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDT8-0426-SM-32PKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27268
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050486
GSE152432_5_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hnf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.9384
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4668-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
UNKL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38826
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2773
GSE179002_0_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Neratinib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0156393
FLOT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06219
NYNRIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44061
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939634
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.867023
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12077
plasma membrane region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.00547
BRD-K48691065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.69981
olaparib_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0160443
cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.15771
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-R53T-0005-SM-3GADK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3566
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.875779
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.25525
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3926	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-K66865641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.69408
Lean Body Mass	DisGeNET Gene-Phenotype Associations	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.40076
SMIM10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76027
B3GAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00630214
seedling	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066113
KPNA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94249
CMYC-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SIGIRR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00603674
BRD-A41304429_Practolol_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K39773004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35347
Primary somatosensory area, nose, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19267
C2BBE1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.31872
partner	GeneRIF Biological Term Annotations	1.0	null
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
SERPINF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.33778
BRD-K81418486_vorinostat_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE261563_3_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3303130-NIHMS40463-supplement-4.xls-KamKwaMuk_AA_differences-human_geneID_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32238
GLDC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74597
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.32658
Uterine Cervical Neoplasms	CTD Gene-Disease Associations	1.0	1.04868
GTEX-NPJ8-1326-SM-3LK6B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946367
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JA-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K17674993_Diflorasone Diacetate_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-3689d	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7075
GOLM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74346
Lung squamous cell carcinoma_LUSC_TCGA-22-4591-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
limbic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NIPSNAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96275
BRD-A47144777_DIHYDRO-7-DESACETYLDEOXYGEDUNIN_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K36me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.96268
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.96687
PRPS1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39904
OVCAR5	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.10363
GSE178255_2_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELAVL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97737
BRD-K62983405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34592
OTX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51177
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14084_KD_FGF13_SRP114701	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.47136
GTEX-WFG8-0426-SM-3GILD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09647
BRD-A28970875_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K68336408_Tyrphostin AG 1478_NCIH1836_6.0_h_56.78_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K98545272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73754
inferior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04834
PMC3470785-NIHMS377161-supplement-3.pdf-237-RXRA_RXRA	Rummagene Transcription Factor Associations 2026	1.0	null
C16orf54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05009
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CD40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70579
Superior olivary complex, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07856
BRD-K62795540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41295
496100584_HIP_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.32517
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39368
CEACAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00648239
Phellem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00872
BRD-K94176593_TWS-119_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
UQCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77524
Lung squamous cell carcinoma_LUSC_TCGA-68-8250-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
endometrium_5a	HPA Tissue Sample Gene Expression Profiles	1.0	2.22011
BRD-K48407262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2634
GSE196117_6_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MXRA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00620548
hsa-miR-3679-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BRD-K86899078_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955161
PROZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00330519
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
hsa-miR-4505	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
PCSK1N	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92717
CHCHD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69447
BRD-M64432851_S1042_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NUDT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00591609
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5369
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K60946512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42172
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
GSE94849_7_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13944
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
arcuate nucleus of medulla, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.49148
Primary somatosensory area, mouth, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09334
KCNJ15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00664773
NKTR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3035
BRD-K47618355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09083
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.67912
RGS11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21761
cuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.830414
BRD-U37049823_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CP in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.827842
GTEX-R55E-0006-SM-2TC5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
BRD-K17497770_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung Injury	CTD Gene-Disease Associations	1.0	1.47736
Lymphnode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.894946
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF483	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25538
IRF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1051
membrane region	GO Cellular Component Annotations 2015	1.0	null
BRD-A11706664_EI-332_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K05104363_PD-184352_MCF10A_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Mammillary body	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00845
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
QGP1	CCLE Cell Line Gene Expression Profiles	1.0	2.40654
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61395
ATP2A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00552529
Npas4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.8316
YARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09631
MAP4K4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58107
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49151
19286929-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
ion channel regulator activity	GO Molecular Function Annotations 2025	1.0	null
BRD-K88670720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37042
ZNF100_01_124	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.86161
PMC3296722-pone.0032481.s009.xlsx-Sheet_1_MSC_vs_references-Gene_Symbol_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
MED23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42893
superficial stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08344
BRD-K38120474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43308
GTEX-U412-0526-SM-3DB9I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942574
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.613361
ZNF398	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2093
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07743
GTEX-XUZC-0008-SM-4BOQG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22498
HLA-DPA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00684956
PMC9396374-Table_4.XLSX-AR_related_genes_from_GeneCards-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE188458_2_v_0_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
voltage-gated ion channel activity	GO Molecular Function Annotations 2015	1.0	null
orbital frontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.78853
MCMBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00448167
TNKS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53593
IZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.976953
GTEX-X3Y1-0926-SM-3P5YT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873028
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
LYSMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50086
CYP3A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00719815
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29258
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7893-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3952
SRA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.17445
BRD-K52341452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01597
Lapatinib ditosylate_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0107293
BRD-K84062787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91311
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.882377
PCGF2-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.919
HT1197	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48977
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE233679_6_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8281-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
liver	GeneRIF Biological Term Annotations	1.0	null
BRD-K70577657_H-9 dihydrochloride_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ABCC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00628675
IFIH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00687121
BRD-K47536398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4178
SMAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92081
BRD-K31992830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46558
SCLY	ChEA Transcription Factor Targets	1.0	null
Phase 2 - plateau phase	Reactome Pathways 2024	1.0	null
MLNR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00494094
PMC7594423-12915_2020_895_MOESM13_ESM.xlsx-Table_S6D-Table_S6D_-_Differentially_Expressed_genes_shared_between_BRCA_TRIM25_amp_and_STAD_CIC_Del_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
Sapanisertib_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0202455
cerebellum	HPA Tissue Protein Expression Profiles	-1.0	-1.41887
BRD-K37145632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24273
Retrosplenial area, lateral agranular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41854
LOXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14265
GTEX-UJHI-0006-SM-3DB8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865272
Primary somatosensory area, barrel field, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75458
GTEX-PSDG-0526-SM-2S1OH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11523
BRD-K23051691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08986
UBXN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17196
FEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47126
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.52035
Acute lymphoblastic leukemia (childhood)	GWAS Catalog SNP-Phenotype Associations	1.0	0.129504
GSE114992,GSE114993_0_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TRPC5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00710193
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07114
skin_5e	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.856328
GSE198165,GSE198166_9_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
FOXQ1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00838832
GSE184892_0_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
k1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.972
CDC37L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68259
CCDC71L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76036
TrigeminalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.943841
BRD-K76910883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13284
PMC5624885-41537_2017_33_MOESM1_ESM.xlsx-SIT1-SIT1_Top_500_differentially_expressed_genes_with_perturbations_in_CNTNAP2_carrier_NGN2-neurons_using_DESeq2_NEUROG2	Rummagene Transcription Factor Associations 2026	1.0	null
TNNC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85115
chr2_223370032_G_A_b38	GTEx eQTL 2025	1.0	1.59108
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
BRD-K17743125_S1085_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MEF2D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00483942
CHST1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00639559
BRD-K03791970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03077
H3K27me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18509
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.66274
TRMT61B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06346
Long QT syndrome 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
RUNDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61041
CCDC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49954
BRD-K21743103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03829
BRD-K76578941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04975
fibrillation	GeneRIF Biological Term Annotations	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67X-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9213
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE197562_0_v_3_nox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21659
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.5542
TMEM145	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.764
voltage-gated potassium channel complex	GO Cellular Component Annotations 2025	1.0	null
amygdaloid complex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.895091
an3ca	HPA Cell Line Gene Expression Profiles	1.0	2.68538
PHYKPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79277
HMCB	CCLE Cell Line Gene Expression Profiles	-1.0	-1.86516
Drug Hypersensitivity	CTD Gene-Disease Associations	1.0	1.10803
GSE214596,GSE214598_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UJHI-1926-SM-3DB8Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881105
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7757
DNAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94586
Potassium channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
suppression	GeneRIF Biological Term Annotations	1.0	null
KURAMOCHI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cerebellar cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01519
Long QT syndrome 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.482
TE-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.19489
Pitavastatin (Calcium)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0130679
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902712
BRD-K81418486_vorinostat_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05045
ventrolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.40522
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02301
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
layer V of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49175
RDES	CCLE Cell Line Gene Expression Profiles	1.0	1.59536
BRD-K52321331_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HS571T	CCLE Cell Line Gene Expression Profiles	1.0	2.00865
cardiac muscle cell action potential involved in contraction	GO Biological Process Annotations 2023	1.0	null
BRD-K79523827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01311
Submandibular lymph node	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
MRS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62029
ZIC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12611
lymphoid leukemia	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.15771
hsa-miR-520d-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Plasma membrane protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
salivarygland	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.892494
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902712
nephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.091189
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.33152
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DNAAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65061
TYW3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89997
channel	GeneRIF Biological Term Annotations	1.0	null
BRD-A77216878_manumycin A_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Right atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.205
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7828-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GM2345	BioGPS Cell Line Gene Expression Profiles	1.0	1.67882
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19638
RAB11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40808
BRD-U82589721_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NA-A4R0-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K52139780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04781
GTEX-PLZ6-1626-SM-3NB23	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08248
Leukemia, Lymphoid	dbGAP Gene-Trait Associations	1.0	0.406869
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
PRKCZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522256
CAPAN1	CCLE Cell Line Gene CNV Profiles	1.0	1.64004
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3N_Peaks_YAP1FAM118B_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
MYLIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78605
H3K4me1_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
GID4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47758
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16515
BRD-K56411643_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE233679_14_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178255_1_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.17895
variability	GeneRIF Biological Term Annotations	1.0	null
BRD-K28296557_Akt inhibitor IV_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K17743125_belinostat_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A-CA-04-2009(H1N1)MA_Day1_22532695_GSE36328	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.6438
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.826
FIGNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36137
MYBPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83288
VIIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14239
HUWE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06203
FLNA	Pathway Commons Protein-Protein Interactions	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
OBSL1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K96377358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89217
hsa-miR-3653	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
ZNF396	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75907
BRD-K90382497_GW-843682X_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K43029808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62735
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ARHGEF18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13106
hsa-miR-542-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
POM121L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0058624
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MOGGCCM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33705
Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78298
abnormal myocardial fiber currents	MGI Mouse Phenotype Associations 2023	1.0	null
GRK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24073
GSE169205_0_v_2_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4258	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
t-tubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.64958
GTEX-XV7Q-0126-SM-4BRVK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879401
Brain Lower Grade Glioma_LGG_TCGA-HT-7860-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
placenta	GeneRIF Biological Term Annotations	1.0	null
SIK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02479
CERS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00526092
RWDD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37059
TAF5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03037
based	GeneRIF Biological Term Annotations	1.0	null
intercalated cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.621831
MIEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40394
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RDH11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67712
Dihydroartemisinin_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0264998
collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.220378
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06361
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18131
FKBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55283
Uterus-pericyte cell	Tabula Sapiens Gene-Cell Associations	1.0	0.112408
PTPRS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00762275
liver	HPA Tissue Protein Expression Profiles	-1.0	-0.769949
MLH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41677
pyramidal layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38351
Inward rectifying potassium channel	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.377
Mammary-fibroblast of breast	Tabula Sapiens Gene-Cell Associations	1.0	5.26163
BRD-K05465626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45886
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.19477
triple	GeneRIF Biological Term Annotations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NB-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
raloxifene-5759	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Anteromedial visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.32931
superficial stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22843
GSE68156_0_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
COL6A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34942
PPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44948
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
heart ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.191007
GTEX-S7SE-0005-SM-2XCEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927468
CRCGN017_MCF10A.WT.HP_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3261
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3346-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GALNTL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00469541
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
GTEX-P4QT-1526-SM-3NMCT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.48244
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-A41199690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26583
Plant glandular hair	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.595
H3K79me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07009
ING3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12815
ANGPTL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00875807
ASPHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05433
icSARS CoV_36Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.43536
Perturb_13751_KO_Bcl3_SRP179718	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.30717
Lung adenocarcinoma_LUAD_TCGA-J2-8194-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K80602847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63173
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE134693_0_v_1_msr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IL6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00557342
ALOX15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00403799
FABP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90457
BRD-K47409867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4026
GTEX-VUSG-1426-SM-3GIJN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857778
CHRNA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08401
temporal lobe	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K61691014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19144
GSE142210_2_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.8072
voltage-gated channel activity	GO Molecular Function Annotations 2015	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8426-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K55044152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.10187
OVTOKO	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49098
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
FLCN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0109942
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.42249
PMC7347220__F5	PFOCR Pathway Figure Associations 2023	1.0	null
recovery	GeneRIF Biological Term Annotations	1.0	null
SNX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34185
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A2QR-11A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEAD1	JASPAR Predicted Transcription Factor Targets	1.0	null
18955564-TableS2b	GeneSigDB Published Gene Signatures	1.0	null
ZNF771	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84775
inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21809
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.968025
PMC9928584-41556_2022_1059_MOESM3_ESM.xlsx-Table_8-Supplementary_Table_8_ETV6-repressed_genes_defined_by_dTAG_at_72_hours_ETV6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A18763547_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8088023-13223_2021_526_MOESM1_ESM.xlsx-sheet1-Table_S1_Twenty-five_AR_genes_retrieved_from_Phenopedia_database_and_references_to_the_original_publication_reporting_their_association_to_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE74528_0_v_1_trex2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00470608
GTEX-S4Z8-0326-SM-3K2AU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49504
TAF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79062
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.897486
BRD-K50140147_NVP-TAE684_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE233679_6_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SIRPA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00485944
Rectum adenocarcinoma_READ_TCGA-AF-2690-01A-02R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164874_5_v_1_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PLPP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46097
Perturb_6131_KO_Sesn1/Sesn2_SRP294204	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GTEX-U8XE-0426-SM-3DB91	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99384
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20247
PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
periventricular stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34288
ADA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17162
primary auditory cortex (core)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.77967
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K58028568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98967
SLC7A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77075
retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069385
abnormality of head or neck	GWASdb SNP-Phenotype Associations	1.0	0.120051
GTEX-O5YW-1826-SM-2YUN2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29006
A172	Achilles Cell Line Gene Essentiality Profiles	1.0	1.50661
Retrosplenial area, lateral agranular part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59732
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40917
BRD-K69932463_AZD-8055_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K92009052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36189
BTN3A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00467896
Cardiomyopathy, Hypertrophic	HuGE Navigator Gene-Phenotype Associations	1.0	null
CTCF-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TC32	CCLE Cell Line Gene Expression Profiles	1.0	1.8499
GTEx Breast 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	3.6834
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YD-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLXNC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583977
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NPAS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45693
BRD-K24512597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.22821
dorsolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.943155
BRD-K16485616_mocetinostat_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K96505704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.70022
BRD-K53046137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.63366
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7655645__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GSE179002_0_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
APLN_KO_GDS3228_601_mouse_Heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-A79768653_sirolimus_PC3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CDX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38942
RHAG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00498212
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57393
BRD-K64514229_Toltrazuril_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S7SE-0526-SM-2XCD8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37938
ROCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39457
ZNF493	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25557
cSARS Bat SRBD_60Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.62738
BRD-K24585433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6702
GSE174701_4_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ECGI10	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66458
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1YW-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZN-0726-SM-4DXT5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76203
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.602
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04587
GSE101537_1_v_3_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pancreatic alpha cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.539
hsa-miR-26b	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
MHHES1	CCLE Cell Line Gene CNV Profiles	1.0	1.35527
SIRT1_KO_GDS4895_410_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-XBEW-0008-SM-4AT3Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03521
BRD-K02093145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40164
intermediate stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36057
AR-22383394-PROSTATE_CANCER-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Uterus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.04017
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13274
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0743
KCND2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K03376048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35457
Perturb_17674_OE_PGRB_SRP252069	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.13104
Choroid plexus epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.404
VMRCRCW	CCLE Cell Line Gene CNV Profiles	1.0	1.75679
BRD-K05002317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47726
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.83361
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Primary motor area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22265
CRCGN017_MCF10A.WT.HP_24H:A23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0972
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13154
MPZL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75371
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K41322154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10588
ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.832399
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUV-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917997
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3888
SALL4	ChEA Transcription Factor Targets	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70J-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCFCP2L1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05219
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
intermediate part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18359
Ankylosing Spondylitides_macrophage_GSE11886	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.78803
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POLR2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00615606
BRD-K24848743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71066
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K97763545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09219
umbilicalcord	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.07591
SLC16A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0057521
SMC1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.010551
BRD-K09689420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79492
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3691
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.4387
SIRT5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00781236
RCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99096
GM2493	BioGPS Cell Line Gene Expression Profiles	1.0	1.271
BRD-K10144853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33771
Long QT syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.633
Primary somatosensory area, lower limb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70404
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-0.839831
rostral paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0547
PPARD-23208498-MDA-MB-231-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H4C12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36844
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.911807
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EMC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59131
CEBPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1352
GSE198794_2_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
GNA15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00443667
BRD-K21955896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40613
Perturb_8655_KO_ESRRA/ESRRG_SRP304242	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MBD3L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80658
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Brain - Caudate (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.658326
NEXN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00460792
TEK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00581913
CHPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76109
STK33	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00585859
BRD-K85722065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16796
SALL4-22934838-CD34+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
SART1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60364
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Diammonium Glycyrrhizinate_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0315955
GTEX-POYW-0726-SM-2XCEO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.17007
shikonin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.59812
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34875
ENHO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24194
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08119
NCIH1092	CCLE Cell Line Gene Expression Profiles	-1.0	-1.98718
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.165
TXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79591
CRCGN017_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.62385
UO31	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.874641
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24562
musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.055881
GSE201239_3_v_4_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Familial atrial fibrillation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.319
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5342
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K76431854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.54747
BRD-K15803157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35529
CXCR5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00527314
CSNK2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12549
C10orf105	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30867
BRD-K15654812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4948
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.867867
LXF-289	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1455
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4355-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPAG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46281
HCC44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.866457
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE143944_1_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
striatum_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.86714
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063595
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.06324
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3943	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
CD200R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00662826
Ventromedial hypothalamic nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15586
BRD-K77504251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31211
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.915329
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39146
GTEX-SNMC-1526-SM-2XCFN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27034
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH1915	CCLE Cell Line Gene CNV Profiles	1.0	1.7116
BRD-K06790927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30652
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
SAP30	ENCODE Transcription Factor Targets	1.0	null
ING2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35527
BRD-K57748937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33749
BRD-K63068307_S1072_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC12917211-Table1.xlsx-Table_S13-Table_S13_Gene-level_perturbation_statistics_from_the_virtual_KLF5_knockout_model_in_malignant_ductal_cells_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4492	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
CRCGN010_HEPG2_24H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36338
Aorta smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.035
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Left ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.336
GSE146074_0_v_11_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K47881755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58184
H2BK15ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
GSE242199_6_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SUPT3H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92286
BIK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00507123
SHP77	CCLE Cell Line Gene Expression Profiles	1.0	2.00712
ZNF790	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54608
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_Jurkat_LPS_vs_DC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.889933
HROB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46146
BRD-K09919985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56872
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26514
BICR 10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.9452
APOBEC3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00594605
PRR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44314
cell periphery	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.228464
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47943
PMC9013323-13577_2022_685_MOESM7_ESM.docx-17-MXD1_MXD1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Atrial appendage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.835
CORL279	CCLE Cell Line Gene Expression Profiles	-1.0	-2.07051
primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03417
primary auditory cortex (core)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10882
Brain Lower Grade Glioma_LGG_TCGA-FG-A4MU-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DGCR6L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84243
kcnq1	GeneRIF Biological Term Annotations	1.0	null
BRD-K51577639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.005
hsa-miR-3183	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
CITED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64327
GTEX-UJHI-1026-SM-4IHJP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01346
MEIS1-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-P78B-2526-SM-3P5ZY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25
hsa-miR-4448	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
KLHL15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22185
BRD-K47508820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59037
BRD-K07460436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55221
abnormality of the immune system	GWASdb SNP-Phenotype Associations	1.0	0.07354
PK-45H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.83655
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN013_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.85629
GTEX-POMQ-1226-SM-3P61F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17804
CHD1	ENCODE Transcription Factor Targets	1.0	null
dexamethasone_homo sapiens_gpl6244_gse20963	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TRAPPC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93313
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MAFF_MAFF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K06956443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56453
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Primary somatosensory area, lower limb, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.41869
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE133763_0_v_1_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Accessory olfactory bulb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24179
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
familial periodic paralysis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.961634
GPR25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34926
BRD-K92723993_imatinib_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FO-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K99048639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90425
Cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
salivarygland_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.857271
BRD-K71726959_N9-isoproplyolomoucine_HEC108_6.0_h_122.55_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SN8G-0526-SM-32PLE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09717
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.960034
BRD-K98164803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42773
GSE101239_3_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Artery - Coronary	GTEx Tissue Gene Expression Profiles 2023	1.0	2.1968
NCOA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48074
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
Ocular albinism 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
hsa-miR-4775	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
SLC28A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00503247
Perturb_5938_KD_NCOA7_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.0094
GSE151829,GSE151831_3_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XLM4-0426-SM-4AT54	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06115
GTF2IRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40121
MED10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49974
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K10696228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.79689
USF1	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K49328571_dasatinib_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S7SE-0826-SM-4AT4D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10553
TIMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45018
intermediate stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00111
C2BBE1	CCLE Cell Line Gene CNV Profiles	1.0	2.42572
BRD-K37687095_AZD-8330_SKBR3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Anterolateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48981
BRD-K06418332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94338
SEC62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14138
BRDT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04868
blood	GeneRIF Biological Term Annotations	1.0	null
Perturb_6501_KD_circSMO_SRP277579	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.38662
MAP1LC3B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98488
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0771
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02512
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.02619
Cardiovascular Diseases	CTD Gene-Disease Associations	1.0	1.28303
H3K27me3_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LY86	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620084
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K07485506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0732
TSEN34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32855
RMI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35897
GTEX-SIU8-0426-SM-4BRUE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08771
MB21D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65918
HCC1937	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73781
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3715
BRD-K77908580_entinostat_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Rutin (trihydrate)_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0177595
CIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75025
OCT4-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SYT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00694023
bleomycin_mus musculus_gpl1261_gse25640	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XUZC-0926-SM-4BOQF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.10398
BRD-K31230200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18354
superior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.953292
hsa-miR-520g	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
RHOH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00430971
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02647
single-organism transport	GO Biological Process Annotations 2015	1.0	null
BRD-K60794504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38235
APLNR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00513401
CLCN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00533604
primary motor cortex (area M1, area 4)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16241
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904678
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.050726
Cardiac conduction	Reactome Pathways 2024	1.0	null
Dlx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.0105
SLC35A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49488
Acute Myeloid Leukemia_LAML_TCGA-AB-2938-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54659
SP in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.944737
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43425
BRD-K08899466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31172
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.89432
hsa-miR-3647-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
hsa-miR-4534	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
HYAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24503
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OXRP-2426-SM-2S1NR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18136
ITGA11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0043063
mantle zone of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02526
GJB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00548919
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K12539581_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JAG1_OE_GDS3571_40_human_endometrial stromal cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Rutin (trihydrate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.021464
Pimitespib_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00918393
NFKBIA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24908
EXOSC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40101
intrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.122262
TMEM178A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28626
intermediate stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33916
BRD-K29328556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04828
BRD-K62555617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64859
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863165
KCNQ1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE149035_1_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
CD247	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00710865
Anteromedial visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81911
GSE221327_4_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAP3K14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53632
RNASE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00940387
Perturb_1337_KD_HMGN3_DRP007117	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.57393
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04721
GTEX-PX3G-2026-SM-48U1H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3912
Retrochiasmatic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6059
Perturb_11615_KD_CCL23_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.15917
DNAL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17391
RIPOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11223
ion channel inhibitor activity	GO Molecular Function Annotations 2025	1.0	null
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1706
GTEX-XMK1-2526-SM-4B666	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72722
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37207
SLC7A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15065
HDAC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61598
Striatum dorsal region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08862
PARP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60573
PIPOX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0067292
SS18L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59692
BRD-K37043259_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KASUMI1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.96446
BRD-K24479270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17609
RTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60959
FIGLA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63014
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.990257
ZNF646	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71735
PMC7347220__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Axolemma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.566
DND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58811
BRD-K05181463_L-741,626_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K01009153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12469
GSE152432_9_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965301
BRD-K16943897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13528
TIAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21924
MYC	ENCODE Transcription Factor Targets	1.0	null
ERA-27197147-CHIP-SEQ-ENDOMETRIOID-ADENOCARCINOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169205_0_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229671,GSE229673_0_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K78659596_MLN2238_SKLU1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FKBP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79975
impact	GeneRIF Biological Term Annotations	1.0	null
kcne4	GeneRIF Biological Term Annotations	1.0	null
Coronary artery disease in type 1 diabetes	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.669897
SCAI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84631
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE174701_4_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101239_5_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K74755318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96798
GSE142210_3_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AQP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00582486
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K86797399_pracinostat_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K86797399_pracinostat_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4904-01A-02R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95369587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34661
Six4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.1389
Asthma	DisGeNET Gene-Disease Associations	1.0	null
GSE133070_2_v_4_prss1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K71842353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35856
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902712
BRD-K76703230_YM-155_HEC108_6.0_h_0.31_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K82433264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02562
PMC10243915-uxad037_suppl_supplementary_table_s1a.pdf-125-REST_REST	Rummagene Transcription Factor Associations 2026	1.0	null
CUX1-19635798-MULTIPLE HUMAN CANCER CELL TYPES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37467
SIK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67083
BRD-K07667918_linsitinib_HEPG2_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K71533707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17257
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
BRD-K99119142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05347
GTEX-OXRO-1226-SM-48TDL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97927
EDEM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94088
USF1_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TFEC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00525324
DLX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34453
Prostate adenocarcinoma_PRAD_TCGA-EJ-7783-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ABCA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00844015
heart muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.41887
dorsolateral part of Med	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15382
PMC4082364-supp_ddu111_ddu111supp_table12.xls-wtWT1_down-Table_S12_MSC_wtWT1_-_top_100_genes_down-regulated_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-NFE2L2_V2-Gene_name_NFE2L2	Rummagene Transcription Factor Associations 2026	1.0	null
MRI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57565
EZH2-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4198
THOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.76863
CRCGN012_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05796
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8066
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-W5X1-2326-SM-3GIL6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895512
FRTL-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.724
BRD-K42964587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50817
superficial stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.2697
ZNF423	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02657
CRCGN009_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03092
hsa-miR-4465	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K97339945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24857
BRD-A28105619_curcubitacin I_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K94070024_depo-medrol_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KAT2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00513631
Adenine_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0143247
PREX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00476752
BRD-K56223790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01005
acute lymphocytic leukemia	GWASdb SNP-Disease Associations	1.0	1.10764
Cortical amygdalar area, anterior part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56951
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.858928
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02301
hsa-miR-767-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
GSE209601_2_v_3_mef2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213219_0_v_1_st3gal3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K08650286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22649
Modiolus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.778
retinal pigment epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.222938
DUSP16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00608134
BRD-K62369921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90914
posteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.90647
PMC7334247-12031_2020_1490_MOESM2_ESM.xls-THAP1_S21T_vs_wt-Gene_Symbol_THAP1	Rummagene Transcription Factor Associations 2026	1.0	null
cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-XUW1-0008-SM-4BOQH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02319
PMC12697342-jem_20250471_tables3.xlsx-large_int_SM-ILF_5_CXCL10-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K35639494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33575
ACACB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36165
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2801
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE221539_1_v_3_lrrc10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30939
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34785
HCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92884
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.952294
BRD-K06320746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19343
cellular process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CREB3L1_CREB3L1	Rummagene Transcription Factor Associations 2026	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09107
TRIM28-17542650-NTERA2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MAMLD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00676934
Retrosplenial area, lateral agranular part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.9378
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Basolateral amygdalar nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1514
FOXK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7147
hsa-miR-524-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
CCL7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00547183
Lactate (calcium)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.015776
GTEX-T5JC-0226-SM-32PMA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27636
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07188
HMGB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59602
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12408
GTEX-XUYS-0008-SM-47JYZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825389
TMEM109	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36795
BRD-K27137352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06782
MRPL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77974
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
INSM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30059
GSE114992,GSE114993_1_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
membrane repolarization	GO Biological Process Annotations 2025	1.0	null
TC71	CCLE Cell Line Gene Expression Profiles	1.0	1.62913
BRD-A79768653_sirolimus_PC3_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.02233
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.899059
CCR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00596422
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.95946
Arrhythmias, Cardiac	CTD Gene-Disease Associations	1.0	1.02821
19843711-TableS1	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.24486
Medial amygdalar nucleus, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.09439
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32836
SPATC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00671852
Cardiac Arrhythmia	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K77830450_forskolin_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BCL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0067264
intermediate stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54997
hsa-miR-383	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
gallbladder_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.20678
parenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.494528
PPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99371
superficial stratum of r8Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17408
hsa-miR-3678-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
VDAC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.9268
GTEX-XPVG-1526-SM-4B66C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33561
hsa-miR-4646-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.127531
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.882377
BRD-K37975989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.99335
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-Fay_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of Pal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07136
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1455
hsa-miR-3942-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.23348
delayed rectifier potassium channel activity	GO Molecular Function Annotations 2025	1.0	null
Colonic mucosa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.217
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12842
CRCGN017_MCF10A.TP53.M_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12625
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K37865504_LY-2183240_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
inhibitory	GeneRIF Biological Term Annotations	1.0	null
PPARD_KO_GSE16048_54_mouse_pancreas (islets, PDX1-expressing cells)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K29662589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39131
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QH-01A-21R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00671571
WAS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00471298
Telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE179880_10_v_13_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IL1RL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00517148
GTEX-S4Q7-1326-SM-4AD74	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29916
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9723
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2609
SMAD4	ChEA Transcription Factor Targets	1.0	null
GTEX-OXRK-0526-SM-3NB2F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46398
GTEX-WHWD-2326-SM-3LK6Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24625
GSE210580_0_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5224
CSNK2A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00373569
BRD-K67870070_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
channel activity	GO Molecular Function Annotations 2015	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hypokalemic periodic paralysis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.602
inactivation	GeneRIF Biological Term Annotations	1.0	null
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K34581968_BMS-536924_VCAP_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LEO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.43212
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057403
Perturb_14503_KO_Tgfb3_SRP020224	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.3288
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-Suppl_Table_6_DEG-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985304
GSE94814_1_v_3_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Capivasertib_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0152794
internal granular layer of CbVCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00279
BRD-K22534934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12471
COL26A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51903
BRD-K87264606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98947
GTEX-P4QS-0226-SM-3NB1U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856487
testis_7d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.89338
r10 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12966
cation transport	GO Biological Process Annotations 2015	1.0	null
NOX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00734272
PROCR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00648243
OVKATE	CCLE Cell Line Gene CNV Profiles	1.0	1.75341
GMCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81351
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44228
M059K	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03357
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.939022
together	GeneRIF Biological Term Annotations	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32448
PAQR8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03542
hsa-miR-300	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
Long QT syndrome 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.269
Perturb_15897_KD_GLI1_SRP241956	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.7004
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.980711
GABBR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00734616
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234289_5_v_0_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ARNT::HIF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2212
TMEM265	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58542
kidney	GeneRIF Biological Term Annotations	1.0	null
GSE178255_2_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
L1CAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00598124
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19589
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JJ-11A-12R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hypersensitivity reaction disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044924
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8499
GSE190235_0_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ADD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.61691
STRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3869
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SIRT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00420061
voltage-gated cation channel activity	GO Molecular Function Annotations 2015	1.0	null
critical	GeneRIF Biological Term Annotations	1.0	null
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902712
NDUFV1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602011
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.2403
INPP4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00627739
Heart	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K27049948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41213
layer 6 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43184
hypersensitivity reaction type i disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.187415
NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.882
BRD-K37480258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06537
NCIH460	CCLE Cell Line Gene Expression Profiles	1.0	1.43303
PIP4P1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7264
HEXA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76108
WASHC2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2585
BRD-K49328571_dasatinib_A375_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-617	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
gastrointestinal system cancer	GWASdb SNP-Disease Associations	1.0	0.166683
Lung Diseases	CTD Gene-Disease Associations	1.0	1.66943
GPR34	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572124
BRD-K24226959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43913
SNU407	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56396
PMC9130782-Table_3.xlsx-downregulated-ZNF366_ZNF366	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K56277358_MGCD-265_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ADAM19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24819
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.60283
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3K_Peaks_wtYAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BF-11A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SOX2-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POU2F2	JASPAR Predicted Transcription Factor Targets	1.0	null
neoplasia of the nasopharynx	GWASdb SNP-Phenotype Associations	1.0	0.969142
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959734
GSE133087_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
18381933-SuppTableS4	GeneSigDB Published Gene Signatures	1.0	null
I band	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.03
BRD-K86027709_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TRMT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49529
GSE184892_7_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE150688_2_v_0_ursolic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CUX1	ChEA Transcription Factor Targets	1.0	null
RAB40AL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.38029
acute lymphoblastic leukemia (childhood)	GAD Gene-Disease Associations	1.0	null
hsa-miR-15b	TargetScan Predicted Conserved microRNA Targets	1.0	0.034317
RGL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10075
voltage-gated potassium channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
SOD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00359854
Z disc	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.072
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24288
BRD-K80738081_resveratrol_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
quadriplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.931656
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924133
GSE67266_7_v_3_etoposide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RAB6C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3418
z disc	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.317082
Gli1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.3615
NPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30704
BRD-K11545984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.78763
GSE169205_0_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RBL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4746
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
Fetal Death	CTD Gene-Disease Associations	1.0	1.59311
GTEX-XPVG-2926-SM-4B66G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886043
BRD-K53417444_OTSSP167_HCC515_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE242199_9_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A34208323_VU0404997-2_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MGAT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00754333
BRD-K98089885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.074
CWF19L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06342
GTEX-S33H-0726-SM-4AD6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28069
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.960034
BRD-K40175214_torin-1_HME1_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0236
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919768
r3 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02469
lomofungin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45795
BRD-K46137903_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
subfamily	GeneRIF Biological Term Annotations	1.0	null
BRD-K31059261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38628
SIN3A	ENCODE Transcription Factor Targets	1.0	null
GSE169205_0_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Supraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2786
BRD-K87053028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01416
BRD-K51544265_cabozantinib_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE213588_9_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A41833852_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K99545815_PF-562271_HME1_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
shell part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4688
Naproxen_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.025681
Cation channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.734
organ system cancer	GWASdb SNP-Disease Associations	1.0	0.123879
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87909389_alvocidib_BT20_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K19227646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04007
studies	GeneRIF Biological Term Annotations	1.0	null
SOX9	ChEA Transcription Factor Targets	1.0	null
H2AC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52059
KASUMI1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.67794
P3H3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00478021
ZNF426	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45931
GTEX-U3ZH-1726-SM-3DB79	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857016
NOTCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86416
SCA1_Knock-in_GDS1756_233_mouse_Forebrain tissue - 4 weeks of age	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SLAMF7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00878997
CUL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00636372
RFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19114
amygdaloid complex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09167
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
19605494-TableS2	GeneSigDB Published Gene Signatures	1.0	null
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K93023309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31145
BRD-K63155804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32976
GSE196699_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.56793
KCNJ13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00573374
MLX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4715
DPYSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61494
BRD-K23666684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31945
ZFX-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
20368555-TS-1	GeneSigDB Published Gene Signatures	1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE220520_3_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213632_1_v_5_acod1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VPS33B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03458
Platelet distribution width	GWAS Catalog SNP-Phenotype Associations 2025	1.0	4.15229
GSE146074_0_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H2AC19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53954
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SLC6A8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00635571
BRD-K06344882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.5001
BRD-K35687265_S1362_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MW-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18246
BRD-K89162000_S1043_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68C-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13211285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.50898
TNFSF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.19886
HESX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608169
Prostate adenocarcinoma_PRAD_TCGA-G9-6364-01A-21R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARHGAP27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58979
GTEX-R55E-0326-SM-48FD2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48914
right atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.292436
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886423
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A822-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4EGI-1_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0268568
BRD-K31273080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28268
Neutrophil percentage of white cells	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.15229
PIGV	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0064214
LAGE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66501
CRCGN016_MCF10A.WT.HP_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0303
BRD-K75649340_Thioguanosine_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K42506600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5376
BRD-K33200274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43426
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07058
GSE137818_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AGAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53959
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.31416
17284527-TableS1	GeneSigDB Published Gene Signatures	1.0	null
CYP1A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00713611
HPS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00513519
GSE130217_5_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6
GTEX-WFON-2526-SM-3LK7P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831056
Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6131-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K27263328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52683
MYCN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00904262
PLXDC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00711602
HS274T	CCLE Cell Line Gene Expression Profiles	1.0	1.79953
metabolic	GAD High Level Gene-Disease Associations	1.0	0.295739
GTEX-QCQG-1426-SM-48U22	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04436
BRD-K29173907_Isoflupredone acetate_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RARB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00472422
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911567
BRD-K24514314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.65541
FCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570796
SDK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0058015
PMC12685885-Table1.xlsx-Table_S9-Du_PanCancer_ATF3_PanPC_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
CENPM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29808
BRD-K82637883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44629
inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.057839
BRD-K84421793_R(+)-SKF-81297_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549	Achilles Cell Line Gene Essentiality Profiles	1.0	1.20202
BLOC1S4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33878
SLC38A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64104
rectum	HPA Tissue Protein Expression Profiles	1.0	1.80738
Sarcoma_SARC_TCGA-IW-A3M4-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU1214	CCLE Cell Line Gene CNV Profiles	-1.0	-2.15327
RASGRP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00278
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.960034
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5QA-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mesothelioma_MESO_TCGA-SC-A6LP-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
precommissural nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.860667
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
MPHOSPH10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11138
Right ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.199
THAP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87073
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0941
BRD-A19500257_geldanamycin_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DOHH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00606142
GSE138001_0_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RHOA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14024
gallbladder	HPA Tissue Gene Expression Profiles	1.0	1.11294
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6384-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sodium Salicylate_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0120777
PIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35487
Narcolepsy	DisGeNET Gene-Disease Associations	1.0	null
STPG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37937
SAP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02174
EP300	ChEA Transcription Factor Targets	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-762	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-K70714754_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-NPJ8-1826-SM-2YUNC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.78099
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0164
Acute Myeloid Leukemia_LAML_TCGA-AB-2982-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K03618428_PP-110_A375_6.0_h_22.2_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DHODH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00481516
inorganic cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.008
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20579
Perturb_11625_KD_EMR4_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	19.0969
PMC4777381-pone.0150624.s007.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
PRKACB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76862
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NANOG-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CEMIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81972
ZNF582	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4642
plant form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061922
NFAT5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00587984
CSNK1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52118
GSE146982_7_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF287	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52381
BRD-K32828673_Chelidonine (+)_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SCL-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AJM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83821
BRD-K09778810_FGIN-1-27_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
layer 2 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.03386
BRD-K68336408_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FUCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53767
previous	GeneRIF Biological Term Annotations	1.0	null
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3955
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1327
DNAJC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73808
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
G6PC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33403
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.35979
GTEX-WOFL-0826-SM-3MJG1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891924
CTSL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23393
BRD-K01734019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77696
BRD-K97666659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41913
SPRING1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79308
Tucidinostat_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0117933
monovalent inorganic cation transport	GO Biological Process Annotations 2015	1.0	null
CD109	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00753577
YKG1	CCLE Cell Line Gene Expression Profiles	1.0	1.55814
hsa-miR-1252	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
voltage-gated potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.895
BRD-K29468949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33976
MAP3K11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.94336
STN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66008
BRD-K66623602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16999
hypocotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067316
GSE165334_3_v_1_dabrafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NUTM2G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.71179
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
Brain Lower Grade Glioma_LGG_TCGA-FG-A710-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K79090631_CGP-60474_HCC515_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L6-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100504_TCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.28346
atrial	GeneRIF Biological Term Annotations	1.0	null
BRD-K96740880_NCGC00182608-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ARHGEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45699
GTEX-OIZH-1526-SM-3NB1J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40136
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963407
BRD-K22246901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96532
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GABPB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82939
CRCGN011_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.727
localization	GO Biological Process Annotations 2015	1.0	null
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.0418
BRD-K19100834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37628
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17264
GTEX-UPK5-1826-SM-3GAEB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929093
less	GeneRIF Biological Term Annotations	1.0	null
TPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09136
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54557
SLC2A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9788
mineral metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.102098
gated channel activity	GO Molecular Function Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4818-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Macitentan_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0270461
AMPK gamma-3_KO_GDS1938_163_mouse_Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
metal metabolism disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.172038
Basal dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.61
BRD-A19037878_trichostatin A_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventricular cardiac muscle cell action potential	GO Biological Process Annotations 2025	1.0	null
BRD-K48099440_Alprostadil_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K76125116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34541
Intercalated cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.15
SFN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38785
GSE179002_0_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Aliskiren_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.017386
rt4	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
GSE63048_11_v_12_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K07071690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15021
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
hkcne4	GeneRIF Biological Term Annotations	1.0	null
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840566
Anterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.95607
18794137-SuppTable1c	GeneSigDB Published Gene Signatures	1.0	null
NEUROD2-26341353-CORTEX-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
central nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.870984
PMC8410083-elife-65574-fig7-data1.xlsx-KLF10_network-Unnamed_25_KLF10	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850885
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HS821T	CCLE Cell Line Gene Expression Profiles	1.0	1.68193
APOL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00993789
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Posterior parietal association areas, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41432
Olig2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8727
BRD-K00909602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1608
TRMU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45181
lateral part of MM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47221
orbital frontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.860722
Liver hepatocellular carcinoma_LIHC_TCGA-YA-A8S7-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RU-01A-31R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of ventricular cardiac muscle cell membrane repolarization	GO Biological Process Annotations 2025	1.0	null
KCTD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21541
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4886-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A55484088_BNTX maleate_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
cardiac muscle cell action potential involved in contraction	GO Biological Process Annotations 2025	1.0	null
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37887
ADCY7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32875
Entorhinal area, medial part, ventral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30283
NR2F2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE137818_5_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ADGRE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00820204
GSE164874_5_v_4_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890976
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11717
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K66271478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18011
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.27544
INKA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84452
TMEM129	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83645
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Testis	GTEx Tissue Gene Expression Profiles 2023	1.0	1.25929
GSE152699,GSE152723_3_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
potassium ion export across plasma membrane	GO Biological Process Annotations 2023	1.0	null
GSE196699_7_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
C8orf33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53003
GSE147056_4_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DUSP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28092
PPP4R3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2501
pparb_23093780_pancreas_lof_mouse_gpl1261_gds4320	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.027319
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22925
CRCGN012_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.60129
NMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70284
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ion channel activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-XOTO-0426-SM-4B66A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918122
right ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.413151
BRD-K65705295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.47988
GSE229671,GSE229673_3_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.7665
GSE131161_5_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PHC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00544622
medial trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24736
FOXQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87314
18381423-SuppTable1b	GeneSigDB Published Gene Signatures	1.0	null
ZNF486	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05111
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.967812
GSE133213_2_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Atrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.636
voltagegated	GeneRIF Biological Term Annotations	1.0	null
ventricular cardiac muscle cell action potential	GO Biological Process Annotations 2023	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K98682310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60449
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6607
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3701
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18122
SNAI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00812969
Perturb_5898_KD_CEBPZ_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.0194
sublayer 6a of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11666
neoplasm of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.33503
PMC5798892-41421_2017_3_MOESM7_ESM.xlsx-TM_KO_vs_WT-Supplementary_Table_S2-2_Up-_and_downregulated_genes_in_ATF6_cells_relative_to_ATF6_cells_in_the_presence_of_TM_early_passage_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
PDIA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78105
Thyroid epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.841
GSE184087_2_v_1_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242199_9_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16445
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.0833
Tongue-pericyte cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.078092
BRD-K95410891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18442
GTEX-O5YV-1626-SM-2YUNJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31582
ZBTB33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55392
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.29972
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.991515
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE67266_7_v_4_etoposide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7995
GP2D	Achilles Cell Line Gene Essentiality Profiles	1.0	1.3455
PROP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44557
TEAD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540327
DT-061_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0231715
MST1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13356
BRD-K64890080_BI-2536_HA1E_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HSG	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.2527
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.925273
tretinoin-3165	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GZMH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00645342
CHD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0050117
layer III of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.46935
Progressive familial heart block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.334
NEIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8532
GTEX-WWYW-0426-SM-3NB31	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66097
GSE142210_4_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.88758
GSE229309,GSE229314_4_v_1_elavl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.2765
Poisoning	CTD Gene-Disease Associations	1.0	1.05163
STAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00885463
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.6434
GTEX-WYBS-0426-SM-3NM9M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883232
hnf4a_16714383_e18dot5_liver_lof_mouse_gpl1261_gds1916	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.703024
u2197	HPA Cell Line Gene Expression Profiles	1.0	1.35269
VAMP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52857
SEC11C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07054
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Mitoxantrone (dihydrochloride)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0152159
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.7
PPAR-Beta_DELETION_GDS4320_363_mouse_Pancreatic beta-cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K65887908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22117
YKG1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.24652
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_A673_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TIAM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00889782
leukemia	GWASdb SNP-Disease Associations	1.0	0.425585
ERLIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90523
GTEX-PLZ5-0426-SM-3P612	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0922
Avian pallium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
APOC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00634943
TRAPPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99229
GSE159678_6_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CYB561A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49074
GABRG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00597526
BRD-K82056353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16612
Perturb_4708_KD_Dnmt3b_SRP069225	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.45926
apical plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
BRD-K31342827_GF-109203X_HA1E_24.0_h_12.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10506
BRD-K19418944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70095
periventricular stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02299
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17258
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09411
BRD-K75746738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.70099
GSE178255_3_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Endocardium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.061
CTCF	ENCODE Transcription Factor Targets	1.0	null
cellular potassium ion transport	GO Biological Process Annotations 2015	1.0	null
BRD-K86797399_pracinostat_HEPG2_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
F11R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0751
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.900981
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962766
GSE179880_10_v_6_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SDC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00447866
Atrioventricular node	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.586
SIRT1_Deficiency_GDS4895_316_mouse_Brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE130217_0_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
G6PD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00697597
Prostate adenocarcinoma_PRAD_TCGA-G9-7522-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.24149
BRD-K28299335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5647
Brain Lower Grade Glioma_LGG_TCGA-P5-A72U-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF876P	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93129
GSE233679_12_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12686523-41421_2025_842_MOESM6_ESM.xlsx-Table_S5-Supplementary_Table_S5_-_Target_genes_of_FOXG1_in_GBM_FOXG1	Rummagene Transcription Factor Associations 2026	1.0	null
HCST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00503114
BRD-K98548675_Parthenolide_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE227592_13_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PHLDA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00664562
BRD-K92884779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18081
BRD-K86143816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08612
weakly	GeneRIF Biological Term Annotations	1.0	null
CYBC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95826
Prostate adenocarcinoma_PRAD_TCGA-G9-6362-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X88G-0426-SM-47JZ5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46766
ITGB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00588891
SYNGR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57479
EP300	ENCODE Transcription Factor Targets	1.0	null
GTEX-X5EB-0008-SM-46MU3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885728
acute lymphatic leukemia	GWASdb SNP-Phenotype Associations	1.0	0.969142
ZFP90	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49861
Ventral premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.063
CCNB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.93669
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.87586
BRD-K89806367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10008
BRD-A72180425_K784-3188_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CBX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00755428
NUMA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37602
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
PMC7075910__F7	PFOCR Pathway Figure Associations 2024	1.0	null
plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.247854
LHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89184
single-organism process	GO Biological Process Annotations 2015	1.0	null
GLI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0070009
SETDB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00485479
BRD-K40175214_torin-1_HME1_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.935374
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.37364
BRD-K89014967_S1475_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ADSS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00618687
BRD-K10870738_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8336-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.51911
RHOXF2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10149
HS604T	CCLE Cell Line Gene Expression Profiles	1.0	1.39381
posteroventral (inferior) parietal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.43531
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K75440064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88241
Atf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.4983
mirp3	GeneRIF Biological Term Annotations	1.0	null
GTEX-U8XE-2526-SM-4E3IT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28914
A673	CCLE Cell Line Gene Expression Profiles	1.0	1.49167
BRD-K97764662_PD-173074_SKBR3_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-A75K-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE89569_3_v_0_nr0b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
WRNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02755
GTEX-X88G-0008-SM-47JWN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47888
Perturb_17235_KD_MAP3K3_SRP389914	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.71578
Basolateral amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22203
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEACAM16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00549404
BRD-K82538319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00374
GTEX-U8XE-1826-SM-4E3HV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45395
BRD-K59049340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	6.27814
Lumateperone (tosylate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0168285
CTSC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00574876
ETV4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.006443
GSE190534,GSE190536_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cochlear ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.788
BRD-K49577636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17303
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.03207
PRDX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31743
Bed nuclei of the stria terminalis, anterior division, rhomboid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05057
Long QT syndrome 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
Arnt	MotifMap Predicted Transcription Factor Targets	1.0	null
HES1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00488031
BRD-K36563688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84333
Lung squamous cell carcinoma_LUSC_TCGA-39-5034-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	GO Molecular Function Annotations 2023	1.0	null
r3 part of spinal trigeminal sensory column, oral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26146
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.921542
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEYL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0443
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
White Blood Cell Count Procedure	DisGeNET Gene-Phenotype Associations	1.0	null
CSRNP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99177
PTGFRN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0063121
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868619
BRD-K79090631_CGP-60474_MCF7_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BAX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16783
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20865
Primary somatosensory area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04537
cterminus	GeneRIF Biological Term Annotations	1.0	null
SUCLG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81079
stratum oriens of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.959396
BRD-K55420858_M9948_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superficial stratum of r3BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29213
septopallidal part of the olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31296
Acute Myeloid Leukemia_LAML_TCGA-AB-2980-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04163641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26882
KCTD20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83199
kv13	GeneRIF Biological Term Annotations	1.0	null
GSE166004_3_v_6_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JG-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25266
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5080-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kinesin II complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.13
NRF2-31884422-A549-HUMAN-LUNG-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_6430_KD_FUBP1_SRP110582	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.14084
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02739
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
osteoblasts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.04419
MXI1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.15254
gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.132233
integral component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.179313
Cone photoreceptor outer segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.553
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98444789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74245
Medial amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10055
GTEX-XAJ8-1226-SM-47JYS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6779
hsa-miR-1343	TargetScan Predicted Conserved microRNA Targets	1.0	0.159923
CLC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17059
BRD-A80151636_BROMOCRIPTINE MESYLATE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SETD7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0044984
Primary B cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	2.00756
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Waist circumference	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.609691
TE8	CCLE Cell Line Gene Expression Profiles	-1.0	-2.311
BRD-K08799216_pelitinib_HS578T_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PRDX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39791
BRD-A13122391_16-HYDROXYTRIPTOLIDE_PC3_24.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
STOML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92138
PLEKHG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57965
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_813_OE_TRIB3_SRP262247	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.31495
AIMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2995
BRD-K60067222_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Common penile artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.086
SLC39A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07305
horizontal nucleus of the diagonal band, transitional part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25177
SUM159PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.685385
BRD-K72264770_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SOHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4761
potassium channel regulator activity	GO Molecular Function Annotations 2023	1.0	null
hsa-miR-3609	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
skin	HPA Tissue Gene Expression Profiles	-1.0	-0.909933
HS578T	BioGPS Cell Line Gene Expression Profiles	1.0	1.15335
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25575
BRD-K70158474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31856
MAPK11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00697758
SEPTIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9302
BET1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68098
IL33	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00860439
BRD-K54732353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02099
Accessory olfactory bulb, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4052
VAChT_KD_GDS4325_361_mouse_Heart from C57BL/6 males	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ovary	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.568424
Lung adenocarcinoma_LUAD_TCGA-73-4675-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30114
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0217
Prostate adenocarcinoma_PRAD_TCGA-G9-6496-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44755
DESI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30613
DSN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56553
Lung adenocarcinoma_LUAD_TCGA-50-5051-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
S1PR5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551067
AGAP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6201
upper (rostral) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.94765
NDUFA11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26757
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.393
delayed rectifier potassium channel activity	GO Molecular Function Annotations 2023	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35873
RIPK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00593868
potassium ion export across plasma membrane	GO Biological Process Annotations 2025	1.0	null
Endopiriform nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59152
medial amygdala, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64196
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00204
hypokalemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.509959
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910952
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.898475
FAM174C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46042
BRD-K75980238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83495
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
prolonged QT interval	MGI Mouse Phenotype Associations 2023	1.0	null
Inferior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9774
CRCGN008_HEPG2_24H:D23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2319
anterior (rostral) cingulate (medial prefrontal) cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.893812
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.948902
PMC9928584-41556_2022_1059_MOESM3_ESM.xlsx-Table_6-Supplementary_Table_6_ETV6-repressed_genes_defined_by_dTAG_at_6_hours_ETV6	Rummagene Transcription Factor Associations 2026	1.0	null
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.839669
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.985745
NOA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25159
MAML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20531
membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-PWOO-0626-SM-48TZH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.989229
BRD-K22475995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75985
RAB3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43576
BRD-K24132293_piperlongumine (HPLC)_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IGR39	CCLE Cell Line Gene Expression Profiles	1.0	1.61101
BRD-K70511574_sunitinib_MCF7_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18921
hsa-miR-4753-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
SAA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0104359
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12611713-Table2.xlsx-Sheet_1-Training_Database_AND_Validation_Database_NOT_Diabetes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
MYO18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34277
Platelet Mean Volume Determination (Procedure)	DisGeNET Gene-Phenotype Associations	1.0	null
ARHGAP23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97628
PMC6137307-mmc2.xlsx-STAT2-IFNa-Table_S1_STAT2-IFNa_Related_to_Figures_1_4_STAT2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06338
skin_5f	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.95191
Perturb_9797_OE_YAP1_SRP132362	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDX2-21402776-INTESTINAL-VILLUS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75795
ovary cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075538
potassium ion transmembrane transport	GO Biological Process Annotations 2025	1.0	null
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.88058
hypokalemic periodic paralysis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.05219
gentamycin-sulfate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06006
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SALL4-22934838-CD34+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
lung	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Ion channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.934786
posteroventral (inferior) parietal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.943202
GTEx Breast 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	4.88633
CRCGN010_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2615
PMC5848610-supp_gr.228809.117_Supplemental_Table_S4.xlsx-Table_S4A-Supplemental_Table_S4A_Differentially_expressed_genes_upon_ZFX_Knock_down_in_C42B_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K12502280_TG101348_SKMEL28_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K56890200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60855
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4899-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAMSTR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90632
TRIM28	ChEA Transcription Factor Targets	1.0	null
Gastric gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.27
HOXA10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76072
NQO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29608
shell of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00352
hsa-miR-4803	TargetScan Predicted Conserved microRNA Targets	1.0	0.159923
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CX-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77323
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09564
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.99838
CRCGN008_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0391
BRD-K46056750_AZD-7762_BT20_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TNKS1BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67954
dorsolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.48529
GTEX-WHSE-1126-SM-3NMBU	GTEx Tissue Sample Gene Expression Profiles	1.0	2.41734
UMRC2	CCLE Cell Line Gene Expression Profiles	1.0	1.90581
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
SNB75	BioGPS Cell Line Gene Expression Profiles	1.0	1.43209
KCNIP2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CAVIN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95139
UCKL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16391
ROPN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00492824
496100431_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.68106
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.888179
FTCD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00434861
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
tamoxifen_homo sapiens_gpl3921_gse33366	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PRKAB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53014
form	GeneRIF Biological Term Annotations	1.0	null
PPARD_KO_GDS4320_619_mouse_Pancreas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PMC5013636-ncomms12601-s5.xlsx-LEF1-Groups_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
Long QT syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.447
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.05898
directly	GeneRIF Biological Term Annotations	1.0	null
Perturb_405_OE_GFI1_SRP302855	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CBLB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00448457
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19173
CLDN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00611749
GSE178907_4_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.61647
GSE137954_4_v_2_smyd3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Logical memory (delayed recall) in normal cognition	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.7
BRD-K32330832_VER155008_PC3_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TRPM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00521967
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02921
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.29425
thyroid gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.113012
Short QT syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.13
GSE198165,GSE198166_6_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NDUFS5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00789042
ANP32D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11712
BRD-K20285085_fostamatinib_HME1_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE189789_0_v_1_oridonin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
ZNF688	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.87239
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.76073
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35268
Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93Y-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050273
BRD-K04409515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11144
immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040631
Perturb_11654_KD_MCFP_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.55604
Perturb_11641_KD_KCNA5_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.17175
PURG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96995
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63258
EHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3637
mkcnq1	GeneRIF Biological Term Annotations	1.0	null
BRD-K53814023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22966
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
stratum pyramidale of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.860099
EDD_DEPLETION_GDS2445_116_human_embryonic fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
19843711-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-WHPG-2326-SM-3NMBP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13004
BRD-K85232515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18832
GSE142210_11_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.898475
LRIG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11967
ventral premammillary nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21556
Long QT syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.796
ETV3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90449
CRCGN010_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10339
GSX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5368
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.852576
GSE157777_2_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SMAD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00453057
BRD-K31898235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35297
TMX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61743
Ezh2_KO_GDS3765_515_mouse_Primary preadipocyte cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Right bundle branch block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
PALM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17928
BRD-K91980109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01019
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4868-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LSR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00394881
GTEX-PLZ6-0826-SM-3P61K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909972
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.859063
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
Lung	GTEx Tissue Gene Expression Profiles 2023	1.0	0.85858
ZNF410	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7406
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930506
NCIH69	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3781
GSE142210_11_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Accessory olfactory bulb, mitral layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54567
BRD-K76008396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75852
TRMT61A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79567
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VW-A7QS-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TFAP2E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6281
Long QT syndrome 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.886
PMC9533694-MOL2-16-3410-s013.xlsx-FIR20vsREST_DEMs-FIR20_vs_REST_DEMs_Down_REST	Rummagene Transcription Factor Associations 2026	1.0	null
Eye-fibroblast	Tabula Sapiens Gene-Cell Associations	1.0	-0.085712
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.56757
GTEX-Q2AG-0626-SM-2S1PV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24555
SW-1116 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.704
BRD-K23701005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57218
BRD-K54604127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08189
GSE184087_4_v_1_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K42995703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30002
IRF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11256
ZBTB45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17395
Myometrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.232
BRD-A58955223_L-sulforophane_SW948_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BHLHE41	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5254
Prostate adenocarcinoma_PRAD_TCGA-TK-A8OK-01A-22R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.607319
GTEX-S341-2026-SM-2XCAA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847062
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2617
BRD-K64632606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0271
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.5769
RPL22L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00538544
MZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21185
FADD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00445305
BRD-K10943878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25773
GSE242199_6_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DDAH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34827
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12077
hsa-miR-331-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.03694
Adenocarcinoma	CTD Gene-Disease Associations	1.0	1.10388
CD5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00591439
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21376
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9996951-40659_2023_417_MOESM3_ESM.xlsx-Osteo_vs_MSC_Array2_hypo_er_txt-Upstream_NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K50720187_F8927_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.58255
CCND2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00883676
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QEG5-1226-SM-447AR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994313
negative regulation of delayed rectifier potassium channel activity	GO Biological Process Annotations 2023	1.0	null
TRAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08899
GJA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33669
GSE142210_3_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.27177
GM2313	BioGPS Cell Line Gene Expression Profiles	1.0	0.915343
present	GeneRIF Biological Term Annotations	1.0	null
BRD-K12040459_AT7867_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998219
BRD-K01292756_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
USF1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03569
PRKAG3_KO_GSE4063_389_mouse_Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ESR1	ChEA Transcription Factor Targets	1.0	null
CRCGN015_MCF10A.TP53.M_24H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18065
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
metal ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.106
intercalated amygdaloid nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13206
Pasireotide (acetate)_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0190003
USP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89891
prepositus hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10182
BRD-K54712090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21427
BRD-K86882815_Cabergoline_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC11625982-AJH-100-10-s001.pdf-26-ZNF682_ZNF682	Rummagene Transcription Factor Associations 2026	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
SCG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09765
Brain Lower Grade Glioma_LGG_TCGA-DB-A75P-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10592962-media-4.xlsx-OC2_genes-gene_ONECUT2	Rummagene Transcription Factor Associations 2026	1.0	null
Brain - Cerebellum	GTEx Tissue Gene Expression Profiles 2023	1.0	1.82955
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.53562
CHO-K1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.082
AGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34029
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.24762
Body mass index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.539794
PMC8901773-41598_2022_7986_MOESM3_ESM.xls-PIO_vs_LPS-Gene_symbol_ENSEMBL_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CD84	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00717191
BCAP31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89928
HERC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32743
BRD-K64935403_E0886_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.988562
LIN28A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60968
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MDA-MB-435S cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.703
NFKBIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8751
DPP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00547827
TDG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0093368
SLC18A3_KD_GDS4325_618_mouse_Heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SCRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25042
Medial preoptic nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29672
BRD-K08316444_-666_SNGM_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.48274
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85836
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
hsa-miR-1297	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.982136
CACNB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0070507
TMCO6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46299
TONSL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93496
TK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06732
primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01671
MZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02299
BRD-K92571446_WZ-3105_PC3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTDNEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78223
VKORC1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00644433
Anteroventral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13299
bcor_22012066_cn_aml_lof_human_gpl570_gds4280	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.105429
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02301
cyclizine-5525	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
specific	GeneRIF Biological Term Annotations	1.0	null
GTEX-Q734-2226-SM-3GAD9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77782
PARVG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00443715
basolateral amygdaloid nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26226
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.53307
AMPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55921
BRD-K35789946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08209
BRD-K62148271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52726
regulation of ion transport	GO Biological Process Annotations 2015	1.0	null
GSE195663_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29259
BAG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00590426
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.895292
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Anteromedial visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.56169
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.5408
SPDEF_01_107	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59186
Adrenocortical carcinoma_ACC_TCGA-OR-A5KU-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urinary	GeneRIF Biological Term Annotations	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.271
GTEX-SNOS-1726-SM-32PLN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967876
PHOSPHO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00589724
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
STAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16331
FN3KRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43573
GSE197555_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06738
PRL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00695273
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.65953
Perturb_6130_KO_Sesn1/Sesn2_SRP294204	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.6404
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.579669
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nose disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.659611
GTEX-QVJO-0526-SM-447CE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04128
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
pontine raphe nucleus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.856119
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.82536
NDUFA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89741
shifts	GeneRIF Biological Term Annotations	1.0	null
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946125
NTSR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00723893
BRD-K25387295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02889
inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.72212
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THEM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72522
MZ in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11868
UterusCorpus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
GTEX-XUZC-2026-SM-4BRW9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17323
Bed nucleus of the accessory olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89609
GTEX-QEG5-0626-SM-2S1PP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17931
BRD-K86371068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01417
BRD-A57762296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23871
Supplemental somatosensory area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71079
Dilated cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
FCHSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23948
BRD-K92428232_GSK-461364_A549_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23935
GSE198794_0_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
TTC19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.40027
hsa-miR-4267	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prostatic Neoplasms	CTD Gene-Disease Associations	1.0	1.02522
TMEM33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60408
BRD-K98145661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00114
Perturb_3002_KO_Lrp5/Lrp6_SRP116923	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.38987
T-tubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.134
Anteroventral periventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20991
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.05015
GTEX-U8XE-0526-SM-3DB8R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47726
BRD-K99252563_QL-XII-47_MCF7_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cisplatin	CTD Gene-Chemical Interactions	1.0	null
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Primary somatosensory area, lower limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.11076
substrate-specific transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
MICA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75712
PAK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00627636
Potassium channel, voltage-dependent, beta subunit, KCNE	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K31884664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54915
GSE225141,GSE225143_2_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STAT3-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VN-A88L-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE195568_2_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VRK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22328
PEX11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72484
BRD-K69854611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20681
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.40442
RANBP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57626
Kdm1a_KD_GDS5055_275_mouse_3T3-L1 preadipocytes - 48h	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K35588268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.55885
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9407
LMX1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46887
FLI1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SCARA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00889817
GTPBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6003
demecarium bromide-5795	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OLIG2-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18618
intrinsic component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.137242
Anteromedial visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.163
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04828
NFE2-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.035087
Busulfan_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0224238
GTEX-REY6-0326-SM-2TF5A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938539
TRIM59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73951
CLK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0052108
FOXO3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.085
NUP155	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7521
TRIM56	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86008
GSE166914_1_v_0_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K47098496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07684
NIBAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21541
CYP2C9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00906108
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.02322
brain	GeneRIF Biological Term Annotations	1.0	null
apical complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.162546
NSUN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.777
Anemia	CTD Gene-Disease Associations	1.0	1.08833
SELE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00681035
GTEX-Q2AH-1926-SM-2S1PN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873749
PLEKHO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64746
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12855
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0858
GAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31537
hsa-miR-4723-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FAM86B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43507
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
SNB19	BioGPS Cell Line Gene Expression Profiles	1.0	1.0502
ZNF341	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70018
OBSL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0065957
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49004
GSE227592_0_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7691-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02455
GSE199606_5_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K90693562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.22326
CEBPB-26923725-CHIP-SEQ-MESODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-O5YV-1126-SM-3LK73	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10379
shsy5y	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
PPP2CA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07474
RGS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03144
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
SNU-638	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47844
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.63613
PEAK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00625423
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06627
Brain Lower Grade Glioma_LGG_TCGA-TM-A84B-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39318389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70803
PMC5798892-41421_2017_3_MOESM7_ESM.xlsx-Veh_KO_vs_WT-Supplementary_Table_S2-1_Up-_and_downregulated_genes_in_ATF6_cells_relative_to_ATF6_cells_in_the_presence_of_Vehicle_early_passage_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
RRAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40371
SCN5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42733
PDLIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11498
GTEX-X4XX-1126-SM-3NMBY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94269
TSNAX	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K09638361_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.845354
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03338
ATG5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00557378
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959975
BRD-K69852452_7241-4207_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BABAM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39714
BRD-K47292239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08575
GSE124471,GSE124488_1_v_0_lats1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OGT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74179
COLO679	CCLE Cell Line Gene CNV Profiles	1.0	1.72013
ITPRIPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8571
Inner ear	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.525
BRD-K86797399_pracinostat_HEPG2_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20654
Muscle contraction	Reactome Pathways 2024	1.0	null
GSE236437_2_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90765
GSE96649_1_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100500_PCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.66796
CRCGN011_HEPG2_24H:A09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04955
septostriatal part of the olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08467
Fatty Liver	CTD Gene-Disease Associations	1.0	1.27224
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33171
ESYT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59523
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PAFAH1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79393
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.02971
r8 part of inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68153
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041306
Lung adenocarcinoma_LUAD_TCGA-73-4677-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BCL11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15988
BRD-K57382977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18262
GSE178255_3_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PSMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10003
Cardiac muscle fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.829
SLC6A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0048113
ABCF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02961
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07617
BRD-K36445086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5491
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0523
NPRL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1109
Lef1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.1924
BRD-K44100512_KIN001-043_HS578T_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-499-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
BRD-K02130563_S1030_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Dexmedetomidine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0219261
BRD-K48501991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0494
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SOX6_SOX6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE214248_0_v_1_cxcl8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Axon initial segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.006
BRD-K88378636_withaferin-a_MDAMB231_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of SePal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24074
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.61164
BRD-K90349877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11735
U251	BioGPS Cell Line Gene Expression Profiles	1.0	0.990787
Acute lymphoblastic leukemia (childhood)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
Primary somatosensory area, lower limb, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.44141
TPRX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.804
SKNO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.8589
HCC1897	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61459
GSE133213_6_v_5_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.824445
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN008_HEPG2_24H:C11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.074
BCL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.006165
channels	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4292	TargetScan Predicted Conserved microRNA Targets	1.0	0.02226
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.33961
EGR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00338921
GSTA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00620128
hsa-miR-4733-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.059817
ZNF605	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18337
APRT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00487889
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SH-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70761
YBEY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6745
TAF1	ENCODE Transcription Factor Targets	1.0	null
JAG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46492
PLK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00542707
Corpus cavernosum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.03
BRD-K71303366_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PCGF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496144
NKX6-3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35478
BRD-K81376179_TCS 359_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K22137463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58978
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH196	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.12097
ITK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00733741
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-V955-1026-SM-4JBHO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22065
Ovarian Neoplasms	CTD Gene-Disease Associations	1.0	1.17596
BRD-K50168500_S1019_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8881251-18_2022_4183_MOESM3_ESM.xlsx-ERM_vs_P4-DEGs_ERM_versus_P4_organoids_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17Z-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K93484038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33248
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PPFIA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92597
superficial stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24736
BRD-K40418847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68267
BRD-K67270926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21134
immune system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.15771
GTEX-UPIC-1526-SM-4IHLU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01175
PDIA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4079
SPIN2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65284
CDON	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58217
Adenosine_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0161615
AZD2858_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0398554
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05007
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.82536
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.77055
Rectum adenocarcinoma_READ_TCGA-F5-6864-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRPS27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06858
GTEX-WEY5-0726-SM-4LMID	GTEx Tissue Sample Gene Expression Profiles	1.0	2.46579
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K61250553_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K12743035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19523
BRD-K37454185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29456
hsa-miR-4512	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
ticlopidine-4074	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K00363054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11025
BRD-K03730976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70603
AtrioventricularNode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55355
subunit	GeneRIF Biological Term Annotations	1.0	null
GTEX-RU72-0826-SM-46MUS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838806
KDM5A	ENCODE Transcription Factor Targets	1.0	null
ILK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00493806
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11922
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K57784254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06201
membrane repolarization during action potential	GO Biological Process Annotations 2025	1.0	null
ACVR2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0064407
nasopharynx	HPA Tissue Protein Expression Profiles	1.0	1.80738
GSE62843,GSE64371_4_v_0_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07455
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06725
CRCGN015_MCF10A_48H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0093
HES7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51707
GSE220806_0_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lymphoblastic leukemia	GWASdb SNP-Disease Associations	1.0	0.481016
GSE216757_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ITM2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2565
BRD-K16238077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13252
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.82212
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4643-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.95631
BRD-K73789395_ZM 336372_HT115_6.0_h_102.71_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55349
regulation of localization	GO Biological Process Annotations 2015	1.0	null
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.910019
HCT15	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50038
GTEX-XOTO-0008-SM-4GICE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881175
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.980711
RAB39A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91678
Lung squamous cell carcinoma_LUSC_TCGA-85-8070-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIHA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05519
GSE111035,GSE111040_8_v_5_plag1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TX-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CKAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06772