association dataset threshold value standardized value Perturb_2309_KD_DHX8_SRP268983 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.02221 GSE127916_1_v_4_nras_human RummaGEO Gene Perturbation Signatures 1.0 null GSE109140_0_v_3_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WVLH-0011-R4A-SM-3MJFS GTEx Tissue Sample Gene Expression Profiles 1.0 1.33641 GTEX-WVLH-0011-R5A-SM-3MJFW GTEx Tissue Sample Gene Expression Profiles 1.0 1.14903 H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null UA-39-TN76_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.341311 DCAF17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51062 ATP5ME CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77994 H3K27me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4QS-0008-SM-48TDY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00684 posteromedial visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46573 becs GeneRIF Biological Term Annotations 1.0 null GTEX-RWS6-0008-SM-47JYV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81094 GTEX-R55G-2426-SM-2TC5I GTEx Tissue Sample Gene Expression Profiles -1.0 -0.929183 ASCL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 99.9849 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A6DV-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial part of the lateral habenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26859 JPT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58441 EIF3G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55363 CD177 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41445 Acute Myeloid Leukemia_LAML_TCGA-AB-2915-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE206729_3_v_1_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null PMC9533694-MOL2-16-3410-s013.xlsx-FIR20vsREST_DEMs-FIR20_vs_REST_DEMs_Down_REST Rummagene Transcription Factor Associations 2026 1.0 null GSE146982_7_v_6_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null KLF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 106.119 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null cerebellar cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.886949 SU-DHL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37278 Cognitive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.368 CORL105 CCLE Cell Line Gene CNV Profiles -1.0 -1.9146 YAP1-20516196-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null mantle zone of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2074 HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1319 telencephalon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.482428 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB7A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JM1 DepMap CRISPR Gene Dependency 1.0 4.11722 MAC2A DepMap CRISPR Gene Dependency 1.0 5.81489 SUM229PE DepMap CRISPR Gene Dependency 1.0 2.49322 esophagus_5a HPA Tissue Sample Gene Expression Profiles -1.0 -1.85091 GSE241402_0_v_1_prmt5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE148200_0_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null KA-63-FH23_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.310246 GSE114883_0_v_5_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null PMC12978397-wjon-17-02-247-s002.xlsx-S2-Suppl_2_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null A704 CCLE Cell Line Gene CNV Profiles 1.0 1.63109 nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.046791 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.2585 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BATF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7083 primary visual cortex (striate cortex, area V1/17)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.856078 GSE226249_2_v_7_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null NEUROD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51349 FLCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52863 Perturb_16888_OE_Sca17_SRP248035 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.14881 H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null AKAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.34636 striatum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.885128 Primary somatosensory area, upper limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0617 Epilepsy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.516 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null RHOT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97539 Brain Lower Grade Glioma_LGG_TCGA-DU-A6S6-01A-21R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Main olfactory bulb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33831 H3K27me3_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null WM-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.33624 MTA3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WVLH-0011-R6A-SM-3MJFZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.01526 BICR10 DepMap CRISPR Gene Dependency 1.0 2.38593 RNF14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49322 GSE146612_1_v_3_amiodarone_human RummaGEO Drug Perturbation Signatures -1.0 null inorganic cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null CTCF_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VSX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25278 hmc1 HPA Cell Line Gene Expression Profiles 1.0 1.00725 NCIH211 CCLE Cell Line Gene Expression Profiles 1.0 2.77589 GSE236437_0_v_3_aldosterone_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE240027,GSE240030_5_v_3_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null r11 part of spinal trigeminal nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12126 GA-59-RW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.503794 ZNF253 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75306 PCDH18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.03895 MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.39662 gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.096429 lateral part of MM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55032 G112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.04526 GSE142430_3_v_1_prmt5_human RummaGEO Gene Perturbation Signatures -1.0 null NCI-H1869 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.91157 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A57G-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4761-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OLFML2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00212 LINGO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18619 GTEX-N7MS-0011-R10A-SM-2HMJK GTEx Tissue Sample Gene Expression Profiles 1.0 1.56573 CYB5D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.14458 mediodorsal nucleus of thalamus_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.953429 UMRC6 CCLE Cell Line Gene Expression Profiles 1.0 1.57506 hsa-miR-3183 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2432 H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null marrow cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.073334 PMC8858874-NIHMS1764275-supplement-Supplemental_Table_2.xlsx-R1_SOX2_bound_genes_5000bp_6-9--Nearest_Ensembl_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null STK26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17161 dorsolateral prefrontal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.998197 cerebellar cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.54356 GLIS2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 106.865 H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MAZ ENCODE Transcription Factor Targets 1.0 null GSE131161_1_v_4_rarres1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Ltk TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.962 ZIC1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 85.0137 GSE77108_4_v_1_saha_human RummaGEO Drug Perturbation Signatures -1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IR-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MYOG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.5276 H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-61-OO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.283233 transporter activity GO Molecular Function Annotations 2015 1.0 null SLC66A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33752 Sarcoma_SARC_TCGA-SI-A71O-06A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.391 ZNF474 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23856 KBTBD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23411 VMRC-LCD COSMIC Cell Line Gene Mutation Profiles 1.0 null transmembrane transport GO Biological Process Annotations 2015 1.0 null mantle zone of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.50598 MANBAL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.17159 catalytic complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.043728 HMCB CCLE Cell Line Gene Expression Profiles -1.0 -1.52332 CORL47 CCLE Cell Line Gene Expression Profiles 1.0 1.99161 phosphorelay sensor kinase activity GO Molecular Function Annotations 2015 1.0 null GTEX-XK95-0008-SM-4AT5G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.97327 PMC10170086-41598_2023_34519_MOESM6_ESM.xlsx-Sheet3-The_overlapping_genes_between_significantly_co-expressed_genes_and_significantly_differentially_expressed_genes_of_BARX2_in_LIHC_BARX2 Rummagene Transcription Factor Associations 2026 1.0 null igr1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.647 ZFAND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37382 Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE173810_0_v_3_igf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null striatum_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.11675 membrane LOCATE Predicted Protein Localization Annotations 1.0 null GSE235066_7_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE92457_9_v_12_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE223334_1_v_0_bcl11b_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AGO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34029 GSE92457_9_v_10_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r10 part of the vestibular column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45649 CTBP2 ENCODE Transcription Factor Targets 1.0 null anterior cortical nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.865243 rhombomere 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08254 GSE169356_0_v_1_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null YAP1 ChEA Transcription Factor Targets 1.0 null SCRN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88138 Anterior cingulate area, dorsal part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10069 GTEX-PWCY-0008-SM-48TE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11741 DOR 13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.9274 nonconvulsive seizures MPO Gene-Phenotype Associations 1.0 null GD-79-TW34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.498622 GTEX-R55D-0826-SM-48FEA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03889 PEX10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75753 SNU626 DepMap CRISPR Gene Dependency 1.0 3.77067 hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.903151 GTEX-XOTO-0011-R1B-SM-4B65C GTEx Tissue Sample Gene Expression Profiles 1.0 1.24634 H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null PKN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8322 potassium GeneRIF Biological Term Annotations 1.0 null GTEX-P44H-0011-R4A-SM-2XCEW GTEx Tissue Sample Gene Expression Profiles 1.0 1.25571 HCC827 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.28388 cerebellar cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.11348 venom apparatus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.883321 QDPR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49538 bone marrow TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066334 Prostate adenocarcinoma_PRAD_TCGA-HC-7740-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ITFG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46308 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.837471 H3K27me3_cardiac mesoderm_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUZ12-20075857-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SUM44PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.50519 ZNF384_02_27 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59309 Cyclic nucleotide-binding domain InterPro Predicted Protein Domain Annotations 1.0 null HSP90AB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4674 superficial stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10293 GTEX-U4B1-1226-SM-4DXT7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16912 icSARS CoV_3Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.64354 496100554_FWM_no dementia_no TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.59803 GSE125014_6_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null PMC7870953-41540_2021_169_MOESM9_ESM.xlsx-SALL2_targets-target_gene_SALL2 Rummagene Transcription Factor Associations 2026 1.0 null PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_15_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GLB1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09775 Infralimbic area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15813 pituitary GTEx Tissue Gene Expression Profiles 1.0 1.46607 93T449 DepMap CRISPR Gene Dependency 1.0 2.25635 Liver hepatocellular carcinoma_LIHC_TCGA-CC-5260-01A-01R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PVOW-1626-SM-48TC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06874 Perturb_17036_KD_RUNX2_SRP265978 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -7.02211 RERF-LC-MS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.18616 LN428 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.8067 YY1 ENCODE Transcription Factor Targets 1.0 null BB-87-SF89_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.244833 dorsolateral prefrontal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.902398 MITF ChEA Transcription Factor Targets 1.0 null cortex of cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18317 improved glucose tolerance MGI Mouse Phenotype Associations 2023 1.0 null GTEX-TKQ2-0008-SM-4DM5L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02906 Cholinergic synapse COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.708 hippocampus HPA Tissue Protein Expression Profiles -1.0 -1.18682 GTEX-S7PM-0008-SM-3NM9Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10658 H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 496100577_FWM_probable Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.11182 intermediate stratum of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.50598 plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 ZNF75A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.4763 GTEX-OXRK-0008-SM-3NB28 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56305 MAIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63045 VEZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.937 P3HR1 CCLE Cell Line Gene CNV Profiles 1.0 1.39811 GSE224763_1_v_0_rif1_mouse RummaGEO Gene Perturbation Signatures -1.0 null RBM15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07742 YAP1-20516196-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25T-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null upper (rostral) rhombic lip_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.912388 GSE211983_0_v_2_nicotine_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC2860895__F1 PFOCR Pathway Figure Associations 2023 1.0 null HCC1569 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE195743_1_v_4_lhx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null Paranoid personality disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.208 GSE96649_1_v_2_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null HNF4 MotifMap Predicted Transcription Factor Targets 1.0 null GP5D COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CDH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32981 THAP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.04 SKLU1 CCLE Cell Line Gene CNV Profiles 1.0 1.60588 CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE102342,GSE102648_1_v_0_curcumin_mouse RummaGEO Drug Perturbation Signatures 1.0 null H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DLX1_02_55 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60007 NOP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43024 fallopian tube HPA Tissue Protein Expression Profiles 1.0 0.882435 GSE111660_2_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null neuroblastoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.231206 H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RU72-0011-R6A-SM-2TF71 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00157 GSE126345_2_v_3_hcrt_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE151612_4_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null inferior occipital gyrus, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.905845 GSE135244_0_v_1_trdmt1_human RummaGEO Gene Perturbation Signatures -1.0 null BCL11A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6425 PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.48454 CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null zfpm2_19411579_heart_lof_mouse_gpl1261_gds3659 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.765748 Lateral amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17511 increased fasting circulating glucose level IMPC Knockout Mouse Phenotypes 1.0 null GTEX-WFJO-0008-SM-4LVN7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3211 Perturb_13741_KO_Nfia_SRP096738 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.61231 GTEX-P4QS-1626-SM-2S1NH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48448 mantle zone of r1Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25864 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.64897 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null RAB21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83252 GSE86507,GSE86509_7_v_9_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null STARD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59099 GPATCH4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74828 NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08162 GTEX-PWO3-0926-SM-2I5EY GTEx Tissue Sample Gene Expression Profiles 1.0 0.854433 TSPO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23368 GTEX-QV31-1626-SM-2S1QC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.97381 esophagus_5b HPA Tissue Sample Gene Expression Profiles -1.0 -0.927611 CHL-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-X261-0011-R10B-SM-4E3JT GTEx Tissue Sample Gene Expression Profiles 1.0 0.924235 MZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08215 GTEX-S33H-0008-SM-4AD6C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40731 NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.65837 GTEX-N7MS-0011-R3a-SM-33HC6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.34704 MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.966633 HCC1599 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.69149 signal transduction GO Biological Process Annotations 2015 1.0 null HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.04526 reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.261624 SUCO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82469 HBEGF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55319 MAP3K14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45406 PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null NDUFS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5249 GTEX-QVUS-0008-SM-447AY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07075 H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCN channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.088 PMC8858874-NIHMS1764275-supplement-Supplemental_Table_2.xlsx-R1_SOX2_bound_genes_5000bp_6-9--Gene_Name_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU1J-0326-SM-46MUM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.883298 BL4711 (PDCD4) NURSA Protein Complexes 1.0 null GTEX-T5JW-0008-SM-4DM5X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08876 Cervix - Endocervix GTEx Tissue Gene Expression Profiles 2023 1.0 2.55956 CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE164483_2_v_0_venetoclax_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-Q2AI-1726-SM-2S1PZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03893 phosphotransferase activity, nitrogenous group as acceptor GO Molecular Function Annotations 2015 1.0 null Perturb_8551_KD_Tet3_SRP056501 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 Oviduct TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 NOL4L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6795 amygdaloid complex_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.83184 GTEX-WVLH-3026-SM-3MJG9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.90473 WDR24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66032 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null pyramidal neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.577615 MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DGKE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3781 EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01174 Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DC-70-EK34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.669294 QGP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00773 H3K27me3_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE184479_1_v_2_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null QA-50-YO37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237769 neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.413151 icSARS CoV_36Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.823609 Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ZBTB7A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS936T DepMap CRISPR Gene Dependency 1.0 3.26536 Primary motor area, Layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33361 GTEX-OOBK-0008-SM-3NB27 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06507 JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.859754 RCOR3-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE192689_0_v_3_ricin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-RWS6-2326-SM-2XCB4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.963531 U343 CCLE Cell Line Gene CNV Profiles -1.0 -1.38586 Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02842 496100514_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.55662 PHF8 ENCODE Transcription Factor Targets 1.0 null Uterine Carcinosarcoma_UCS_TCGA-NG-A4VW-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REST-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null TE-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null PLPP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51489 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TKQ1-0226-SM-33HB5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48365 GSE121043_0_v_1_aldh1a1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SUCS-0008-SM-4DM53 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 GTEX-T5JW-1726-SM-3GADN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17535 CD8_Naive_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.02242 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null voltage-gated potassium channel activity GO Molecular Function Annotations 2023 1.0 null GSE239844_8_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null AQP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68371 SRGAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69983 TMTC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43619 cerebellar cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08592 TCIRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60988 GSE253041_3_v_0_ramp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Tic disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.935 GTEX-WHSE-3026-SM-3P5ZH GTEx Tissue Sample Gene Expression Profiles 1.0 2.29842 ZNF343 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.0907 PMC7412812-13059_2020_2115_MOESM11_ESM.xlsx-All_EZH2-Upregulated_in_SERBP1_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-U8XE-1526-SM-4E3HT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.896136 appendix HPA Tissue Protein Expression Profiles 1.0 0.882435 HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.883782 CHO cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.266 membrane part GO Cellular Component Annotations 2015 1.0 null GTEX-XOTO-0011-R3A-SM-4B64W GTEx Tissue Sample Gene Expression Profiles 1.0 1.56083 CA1 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19659 MAT2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.36626 IGR-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_16517_KD_C11orf53_SRP343255 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 ZNF706 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02683 GTEX-T5JC-0011-R11A-SM-32PMB GTEx Tissue Sample Gene Expression Profiles 1.0 0.908383 POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CASKIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.69487 periventricular stratum of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32381 abnormal spatial reference memory MPO Gene-Phenotype Associations 1.0 null FOXM1-26456572-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null metal ion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null glia TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.102019 Gill raker TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.749 BTRC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51194 BLOC1S4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25461 SC-72-YW56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.251073 GTEX-Q2AG-2926-SM-2HMJ3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.93626 PLAU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80031 CHD2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PK-45H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.972927 GTEX-UTHO-0011-R3A-SM-3GIK8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09075 PMC12439337-thnov15p9091s1.pdf-45-ENSG00000126561_STAT5A Rummagene Transcription Factor Associations 2026 1.0 null TFCP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.16484 autonomic nervous system neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.182957 UBB_KO_GDS3906_494_mouse_Testis - 21 Days GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K4me1_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MFSD14B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.1538 CWF19L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06342 REP15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55643 MPHOSPH10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11138 VZ in caudal cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.859523 GTEX-WZTO-0011-R6B-SM-4E3J6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18448 GSE146612_2_v_0_amiodarone_human RummaGEO Drug Perturbation Signatures -1.0 null MYC ENCODE Transcription Factor Targets 1.0 null H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KP2 CCLE Cell Line Gene CNV Profiles -1.0 -1.48588 Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5QE-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JHUEM3 CCLE Cell Line Gene Expression Profiles -1.0 -2.92436 H3K27me3_H7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Macaque_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null DNAJC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73808 PMC11772884-41421_2024_747_MOESM6_ESM.xlsx-7_DEGs_USF2-KO_vs_control-Gene_Symbol_USF2 Rummagene Transcription Factor Associations 2026 1.0 null TP63 ChEA Transcription Factor Targets 1.0 null cerebralcortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.940692 ARL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05259 Brain Lower Grade Glioma_LGG_TCGA-HW-7489-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UQCR10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57224 r1 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28219 GSE161295_0_v_1_cdk8_mouse RummaGEO Gene Perturbation Signatures -1.0 null IKBKG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70684 KAP1-27257070-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me1_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null malignant glioma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.378143 CTCF_fibroblast of skin of abdomen_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ISCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.36115 GSE92457_7_v_8_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null FF-28-ES17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.905105 RPS15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40092 Leading edge membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.677 GSE142210_9_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null 496100367_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.33934 HS-SULTAN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18869 hsa-miR-125b TargetScan Predicted Conserved microRNA Targets 1.0 0.082179 spinal cord TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.089453 MYOG ENCODE Transcription Factor Targets 1.0 null ZNF341 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.4904 FANCA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32228 NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.50381 GSE228106_0_v_1_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null Main olfactory bulb, inner plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.6744 Anterior olfactory nucleus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38047 GSE113734_3_v_0_qprt_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FAM120B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85166 receptor signaling protein activity GO Molecular Function Annotations 2015 1.0 null COLO 201 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03228 GSE224096_2_v_0_cocaine_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_9425_KD_H3F3A_SRP150639 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.84217 SNU216 CCLE Cell Line Gene CNV Profiles -1.0 -1.41331 GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles 1.0 1.20205 SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.870054 TSG101 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08244 H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FOXH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04543 dorsal spiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.94649 EJM CCLE Cell Line Gene CNV Profiles -1.0 -1.49893 GTEX-TKQ1-0326-SM-4DXSM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29231 H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NRDC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.15456 dorsal cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.78624 potassium channel activity GO Molecular Function Annotations 2015 1.0 null AMIFAMPRIDINE PHOSPHATE DGIdb Drug Targets 2026 1.0 0.189043 TRMT61B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06346 GATA3-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GALNT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85786 hsa-miR-3173-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.078844 Sarcoma_SARC_TCGA-DX-A7EO-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE160001,GSE160670_3_v_2_lapatinib_human RummaGEO Drug Perturbation Signatures 1.0 null SE-15-AV21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.359755 Entorhinal area, medial part, ventral zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01338 SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5537 Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.556 GTEX-WHSB-0005-SM-3LK7C GTEx Tissue Sample Gene Expression Profiles 1.0 1.12616 GSE211286_1_v_5_tcf12_mouse RummaGEO Gene Perturbation Signatures -1.0 null macroglia TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063522 GTEX-NPJ7-0011-R6a-SM-2I3G7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.89513 NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04419 GSE149901_2_v_1_anlotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE211983_0_v_3_nicotine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE166783_1_v_2_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null HCT 116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.44586 DSG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91122 CSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01652 mRNA_ZSCAN4C_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.89394 ion channel activity GO Molecular Function Annotations 2015 1.0 null HOXC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47685 RKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.85475 signaling GO Biological Process Annotations 2015 1.0 null H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KIF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.64892 GSE148695,GSE167284_2_v_1_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null inhibition GeneRIF Biological Term Annotations 1.0 null REST ChEA Transcription Factor Targets 1.0 null MOLT-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null 496100562_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.37792 ZNF610 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 95.9476 abnormal behavior MPO Gene-Phenotype Associations 1.0 null NIPAL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86076 GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05479 Brain Lower Grade Glioma_LGG_TCGA-P5-A5F4-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MFE-319 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PWN1-0008-SM-48TEA GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 hsa-miR-1913 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 mRNA_TCF3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null CITED1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.57121 upper (rostral) rhombic lip_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.09401 cellular_component GO Cellular Component Annotations 2015 1.0 null GSE128333_3_v_0_tcf4_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-O5YV-1626-SM-2YUNJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13189 ECD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5192 H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Primary somatosensory area, mouth, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28609 CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SN8G-0526-SM-32PLE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15534 GSE109140_2_v_1_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null SCC9 CCLE Cell Line Gene CNV Profiles -1.0 -1.67761 GSE103124_1_v_0_bmpr1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE139016_3_v_2_disulfiram_human RummaGEO Drug Perturbation Signatures -1.0 null PMC11659471-41398_2024_3203_MOESM2_ESM.xlsx-Table_SE_9-Table_SE9_Z_scores_comparing_signficant_genes_from_OUD_dataset_Seney_et_al_and_rat_models_of_heroin_and_or_LPS_injection_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null VZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35159 GTEX-PVOW-0008-SM-48TE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77711 CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 18974375-TableS5a GeneSigDB Published Gene Signatures 1.0 null Prelimbic area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1186 Perturb_4193_KO_Mbnl1_SRP057123 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.8097 UCHL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5147 IOMMLEE CCLE Cell Line Gene Expression Profiles 1.0 2.29306 GTEX-O5YT-1626-SM-32PK6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13571 OPM2 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.86014 SKP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41801 GSE142210_9_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null TPBGL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26607 PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null H3K4me3_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hippocampal pyramidal layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.577215 CFAP68 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57331 SUZ12-27294783-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MN-60 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-S341-1826-SM-3K2AB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53271 GTEX-QVJO-1426-SM-2S1QY GTEx Tissue Sample Gene Expression Profiles 1.0 1.50298 lateral ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.35948 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.859754 urinary bladder HPA Tissue Protein Expression Profiles 1.0 0.882435 HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31248 H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null MKN45 COSMIC Cell Line Gene Mutation Profiles 1.0 null SKM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.851216 MACC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08599 C10orf82 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82599 Endolymphatic hydrops DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.333 outer SZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.877943 HNRNPUL1_02_156 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.45943 TMEM120A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07691 internal granular layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19215 CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.929678 PRR14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67217 OSBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43868 SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.5739 intermediate stratum of r1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01953 CTCF_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CXCL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76537 outer SZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.953462 single-organism cellular process GO Biological Process Annotations 2015 1.0 null GTEX-RM2N-1826-SM-2TF5B GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 BAD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97072 RPS23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15967 GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30119 GSE206226_2_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Specific developmental disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.318 PAX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16391 NCIH1693 CCLE Cell Line Gene CNV Profiles 1.0 2.15597 GSE169152_5_v_7_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null stratum pyramidale of caudal CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.944816 MTRES1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07783 OSBPL11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65349 HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.04409 G130 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11865 GTEX-S7SE-0011-R4A-SM-2XCDB GTEx Tissue Sample Gene Expression Profiles 1.0 1.67326 glioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.466885 Perturb_9170_KD_CFTR_ERP118933 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.99985 GSE133764_2_v_0_chd2_human RummaGEO Gene Perturbation Signatures 1.0 null Attention deficit hyperactivity disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.556 H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null vorinostat_homo sapiens_gpl6947_gse41504 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RABL2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25272 Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.368 H3K4me1_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CBP-21632823-H3396-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-S7SE-0011-R7A-SM-2XCDI GTEx Tissue Sample Gene Expression Profiles 1.0 1.16614 GTEX-T6MN-0011-R4A-SM-32QPG GTEx Tissue Sample Gene Expression Profiles 1.0 0.889046 H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149943_1_v_3_cd8a_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZFHX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89328 Perturb_4181_KO_Foxp1_SRP107214 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.93033 GSE201217_4_v_6_usf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GSE236280_0_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null abnormal spike wave discharge MGI Mouse Phenotype Associations 2023 1.0 null GSE216043_11_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null PGLYRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26584 SIN3B ChEA Transcription Factor Targets 1.0 null dorsal part of JcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.50598 PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1ME-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular potassium ion transport GO Biological Process Annotations 2015 1.0 null SLC7A11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38527 membrane LOCATE Curated Protein Localization Annotations 1.0 null cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.200328 GSE192689_0_v_1_ricin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-55-6978-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE224004,GSE224005_0_v_1_chd4_human RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4338-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null METTL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.162 H3K9ac_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null regulation of transport GO Biological Process Annotations 2015 1.0 null AF-10-BU38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.248394 TSC22D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54937 CTCFL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.4057 FABP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01692 GSE148066,GSE157787_5_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null EPM2AIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.19005 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IC-76-JU42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.230522 GSE242199_2_v_0_ntrk2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE139348,GSE139349_1_v_0_dicer1_mouse RummaGEO Gene Perturbation Signatures -1.0 null COPS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24464 PTCD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36076 Sjogren'S Syndrome DisGeNET Gene-Disease Associations 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BD-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.44602 CALU1 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.35554 GTEX-TSE9-0008-SM-4DXT8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.868445 GTEX-RVPU-0011-R5A-SM-2XCAD GTEx Tissue Sample Gene Expression Profiles 1.0 0.94315 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.915758 DU4475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.90265 H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SLC30A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04316 POLR2A ENCODE Transcription Factor Targets 1.0 null ovary cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060898 CB-16-SY72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.279348 KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.925025 Gilles de la Tourette syndrome DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.935 rt4 HPA Cell Line Gene Expression Profiles -1.0 -1.15888 stratum lacunosum-moleculare of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.02903 KCND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.30216 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null subgranular zone of rostral dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20351 CCNE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04909 CREB3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.5084 SU-DHL-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18499 GTEX-QDT8-0011-R3A-SM-32PKR GTEx Tissue Sample Gene Expression Profiles 1.0 1.25247 SOX30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49638 NDOR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70715 Arcopallium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.524 voltage-gated channel activity GO Molecular Function Annotations 2015 1.0 null PD-05-HV36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203467 PB-18-HD85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.245169 NCIH2122 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.1678 GTEX-NPJ7-2726-SM-2I3FT GTEx Tissue Sample Gene Expression Profiles 1.0 1.13906 Perturb_12597_KD_Gatad2b_SRP366371 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.84977 Lung squamous cell carcinoma_LUSC_TCGA-90-A4EE-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE175787_4_v_7_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-0011-R7a-SM-2HMKN GTEx Tissue Sample Gene Expression Profiles 1.0 0.937325 ZNF583 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74211 CALU3 CCLE Cell Line Gene CNV Profiles -1.0 -1.43779 Neuroendocrine cell_Trachea_Mouse CellMarker Gene-Cell Type Associations 1.0 null ELK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81101 OVCAR-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Secondary motor area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.98929 SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.88876 GTEX-RNOR-0008-SM-48FEY GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 TOV112D Achilles Cell Line Gene Essentiality Profiles -1.0 -1.02037 ZBED4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 106.27 SUOX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.51534 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZG-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.851951 H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null subgranular zone of caudal dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.953537 NDUFS7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2323 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null gallbladder HPA Tissue Protein Expression Profiles 1.0 0.882435 Venom gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.836 CTCF_retinal pigment epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZIC5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 105.324 PRNP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37635 HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.984166 GTEX-NPJ8-1826-SM-2YUNC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22001 Main olfactory bulb, mitral layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46573 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2432 abnormal retina morphology MGI Mouse Phenotype Associations 2023 1.0 null GSE159446,GSE159449_1_v_0_tunicamycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE148066,GSE157787_11_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null NKX2-3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80208 GTF2H5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76924 GTEX-R55E-2726-SM-48FCX GTEx Tissue Sample Gene Expression Profiles 1.0 1.23077 ZNF148 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 133.261 CDK8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56723 ZNF724 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88536 intermediate stratum of m2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53543 PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null CYSRT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53232 GSE206516,GSE206518_5_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE84148,GSE96938_0_v_2_nrros_mouse RummaGEO Gene Perturbation Signatures -1.0 null SUZ12-18974828-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null BHLHE40 ENCODE Transcription Factor Targets 1.0 null GSE149943_2_v_0_cd8a_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZBTB7A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ion transmembrane transport GO Biological Process Annotations 2015 1.0 null CTCF_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SE-0008-SM-33HB1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62573 CTCF_GM20000_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7402-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P78B-0008-SM-48TE1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55912 CRNKL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81045 Skin BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.06814 GSE120415,GSE120447_0_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-69-8453-01A-12R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00841 GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81819 ZBTB6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.0117 hyperactivity MGI Mouse Phenotype Associations 2023 1.0 null brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GPI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02449 H3K27me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-RQ-A68N-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S4UY-0226-SM-3K2AP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08044 striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.14692 GTEX-N7MS-2625-SM-3LK77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2921 Primary motor area, Layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25552 hsa-miR-335-5p MiRTarBase microRNA Targets 1.0 null H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WHSE-2926-SM-3NMBG GTEx Tissue Sample Gene Expression Profiles 1.0 0.83292 BC-62-RZ55_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.319137 EVPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15378 SSX2IP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97577 GPX8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04642 Anteromedial visual area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25285 inorganic cation transmembrane transport GO Biological Process Annotations 2015 1.0 null GSE112365_0_v_1_sirt1_human RummaGEO Gene Perturbation Signatures -1.0 null ABHD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36334 ovary BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.906656 PMC9174176-41467_2022_30924_MOESM6_ESM.xlsx-OC2-SYMBOL_ONECUT2 Rummagene Transcription Factor Associations 2026 1.0 null genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.044107 MFF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99543 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null channel GeneRIF Biological Term Annotations 1.0 null r6 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.82547 GALR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00574 Perturb_7133_KD_HS51/NRSE_SRP261089 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 10.0077 mRNA_SFPI1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null PLAG1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 102.278 VSIG10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67989 ANKRD34B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36296 astroglia TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.067269 BECKER DepMap CRISPR Gene Dependency 1.0 2.59541 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null GSE147876,GSE147877_4_v_9_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null MCF7 DepMap CRISPR Gene Dependency 1.0 2.23044 GTEX-NFK9-0008-SM-4E3JE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 GSE142210_9_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null increased fasting circulating glucose level MGI Mouse Phenotype Associations 2023 1.0 null GTEX-XQ3S-0426-SM-4BOOA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05689 SRSF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14719 GTEX-NL4W-0011-R5a-SM-2I3GD GTEx Tissue Sample Gene Expression Profiles 1.0 0.847376 orbital frontal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.884776 Retrosplenial area, lateral agranular part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12668 ERG28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66298 GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.949988 H3K9ac_Peripheral Blood Mononuclear Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.843549 GTEX-U8XE-0626-SM-3DB8U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23921 ANKRD33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99739 Sarcoma_SARC_TCGA-HS-A5N8-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QVJO-0011-R6A-SM-2S1QN GTEx Tissue Sample Gene Expression Profiles 1.0 0.918228 intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 MXRA8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75597 ALG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58974 NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.992288 E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55E-0011-R1A-SM-2TC6N GTEx Tissue Sample Gene Expression Profiles 1.0 1.47571 GTEX-REY6-0326-SM-2TF5A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45732 GSE201217_2_v_1_usf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SG in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.870442 GTEX-UJMC-0008-SM-4IHKK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17627 H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null posteromedial visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34781 TrigeminalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.03769 Perturb_15437_KD_NUSAP1_SRP074246 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.05608 GSE224096_3_v_0_cocaine_human RummaGEO Drug Perturbation Signatures 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70W-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE146982_4_v_2_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null MOLT-16 COSMIC Cell Line Gene Mutation Profiles 1.0 null functions GeneRIF Biological Term Annotations 1.0 null GTEX-T6MN-0011-R5A-SM-32QPD GTEx Tissue Sample Gene Expression Profiles 1.0 1.16311 stomach HPA Tissue Protein Expression Profiles 1.0 0.882435 SMARCAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17038 rostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.998224 ventrolateral prefrontal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.895267 RAB6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.89694 GSE183251_1_v_5_cyp2c70_mouse RummaGEO Gene Perturbation Signatures 1.0 null central nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.469599 H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null PMC4266008-mmc3.xlsx-iPS-MSC_vs_MSC-Unnamed_24_MSC Rummagene Transcription Factor Associations 2026 1.0 null MZ in retrosplenial cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.881522 Rectum adenocarcinoma_READ_TCGA-DC-5337-01A-01R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_2154_KD_SPRY1_ERP114848 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.13699 cerebellar nuclei of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08767 GSE196117_1_v_11_clarithromycin_human RummaGEO Drug Perturbation Signatures 1.0 null ion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null YY1AP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11286 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKNFI CCLE Cell Line Gene CNV Profiles 1.0 1.44066 CF-65-GU65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.589362 ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ALKBH4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19481 H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null DA-35-DU85_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.265191 H3K4me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE231891_3_v_4_cdk8_human RummaGEO Gene Perturbation Signatures -1.0 null NFE2L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44945 H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CCDC85B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0969 MONOMAC1 Achilles Cell Line Gene Essentiality Profiles 1.0 1.0962 GSE142684_2_v_7_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null ESR1-30970003-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null GTEX-TSE9-0011-R4A-SM-3DB7H GTEx Tissue Sample Gene Expression Profiles 1.0 1.28199 extrinsic component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.367388 VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null ZNF222 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33673 HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.859982 BRSK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90723 stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.976827 ChIP_SUZ12_18974828 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.861614 CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.72394 MAFK_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T2IS-0011-R5A-SM-32QP4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.928235 HIVEP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50999 GTEX-RVPV-0011-R5A-SM-2TF69 GTEx Tissue Sample Gene Expression Profiles 1.0 0.936211 GTEX-WVLH-0011-R10A-SM-3MJFM GTEx Tissue Sample Gene Expression Profiles 1.0 1.60319 KLF4 ChEA Transcription Factor Targets 1.0 null SFT2D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06281 ACN COSMIC Cell Line Gene Mutation Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19T-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of ZIC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14303 SLC30A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.43313 GSE80446_2_v_1_anakinra_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE196117_1_v_0_clarithromycin_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF740 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 160.973 ZNF75A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87774 IALM CCLE Cell Line Gene Expression Profiles -1.0 -2.38329 ZNF263 ENCODE Transcription Factor Targets 1.0 null H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ChIP_H3K27me3_18600261_mouseWholeBrain ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE214823,GSE214824_6_v_7_crtc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE242290_1_v_8_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null GLIS3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 51.6963 hsa-miR-4650-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.828473 Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5561-01A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null monoatomic cation transmembrane transport GO Biological Process Annotations 2025 1.0 null GSE208096_1_v_0_progesterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null TFAP2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 162.641 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null Perturb_3755_KD_RNF40_ERP110773 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 cerebellum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.72917 NCI-H1435 COSMIC Cell Line Gene Mutation Profiles 1.0 null H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.66875 improved glucose tolerance IMPC Knockout Mouse Phenotypes 1.0 null GSE154074_2_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03435 ZNF416 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71222 PAS-associated, C-terminal InterPro Predicted Protein Domain Annotations 1.0 null organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056253 GSE153189_2_v_3_stat1_mouse RummaGEO Gene Perturbation Signatures 1.0 null outer SZ in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.90334 cell part GO Cellular Component Annotations 2015 1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.473869 EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHEK1_knockdown_95_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.78011 BMI1-23680149-NPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE205630_0_v_1_gmds_human RummaGEO Gene Perturbation Signatures 1.0 null NACC1-18358816-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.856475 NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02726 breath tests GAD Gene-Disease Associations 1.0 null PCM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9041 ING5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.94687 FB-66-UU47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.240969 Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3TU-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PWOO-0008-SM-48TDU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.972242 cerebral cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.493354 GTEX-X585-0011-R1B-SM-46MVE GTEx Tissue Sample Gene Expression Profiles 1.0 1.47105 dorsal juxtacommissural pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.48662 GSE172016_2_v_5_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null PIM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40797 behavior/neurological phenotype MPO Gene-Phenotype Associations 1.0 null PMC11196642-41419_2024_6838_MOESM5_ESM.xlsx-Supplementary_Table_3-Supplementary_Table_3_Differentially_expressed_genes_in_RNA-seq_between_MCF7_SMAD4-KO_and_parental_groups_SMAD4 Rummagene Transcription Factor Associations 2026 1.0 null IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.47265 TCF3 ENCODE Transcription Factor Targets 1.0 null NDUFA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01001 CTCF_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.42036 GSE142210_11_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-U3ZM-0526-SM-4DXTB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03691 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KM-8439-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF77 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92851 TMEM33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.60291 CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_K27me3_17603471_mouseMEF ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NR0B1-18358816-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8512-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-8358-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAZ JASPAR Predicted Human Transcription Factor Targets 2025 1.0 72.3258 GTEX-WHSE-0011-R3A-SM-3P5ZM GTEx Tissue Sample Gene Expression Profiles 1.0 1.90736 external granular (germinal) layer of upper rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.997703 CTCF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPTY2D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65854 NFIC_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZNF93 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 129.541 H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Posterior parietal association areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14746 WM115 CCLE Cell Line Gene CNV Profiles -1.0 -2.5066 GSE65617_0_v_4_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null C3A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.845723 H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Electrocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.584 ATG4D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94866 KMS-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.88768 molecular layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.67132 BRCA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44454 CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEP170B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04892 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XLM4-3026-SM-4AT6L GTEx Tissue Sample Gene Expression Profiles 1.0 1.89159 ODR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77563 PSME1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86704 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-QVUS-0011-R3A-SM-3GAFD GTEx Tissue Sample Gene Expression Profiles 1.0 1.08244 GTEX-XXEK-0326-SM-4BRVV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.965774 GSE158285_0_v_1_ddx5_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WY7C-2826-SM-3NB3Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15216 H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FTSJ3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14468 medial portion of the shell Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08831 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WNK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34438 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null rostral migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.941063 MCF10F Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.12905 ETV2::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.6864 Duodenum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 HF-91-IU60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.27344 NCIH596 CCLE Cell Line Gene CNV Profiles -1.0 -1.33736 Accessory olfactory bulb, mitral layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40441 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.083 PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_19_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Gall bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 HCC4017 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19316 u2197 HPA Cell Line Gene Expression Profiles -1.0 -1.15888 ERF::NHLH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 64.2274 GTEX-QV44-2026-SM-2S1RD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.961884 H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX ENCODE Transcription Factor Targets 1.0 null Anterior cingulate area, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54055 OB-17-DQ74_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20455 mRNA_SOX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null CRB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29215 SKMG1 DepMap CRISPR Gene Dependency 1.0 3.62113 HK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81977 GTEX-T6MN-0011-R6A-SM-32QP8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08998 MDAMB435S DepMap CRISPR Gene Dependency 1.0 2.2618 PRDX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72195 phosphorelay signal transduction system GO Biological Process Annotations 2015 1.0 null erythroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.451042 dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.28077 ZR751 CCLE Cell Line Gene Expression Profiles -1.0 -1.5225 H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WY7C-2426-SM-3NB2V GTEx Tissue Sample Gene Expression Profiles -1.0 -0.864798 GSE153443_1_v_3_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null KLF14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 120.001 ARL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55874 GTEX-QEG5-1426-SM-447AS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.938876 GSE146982_3_v_2_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.7583 SF295 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null AAR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26333 GTEX-UTHO-3126-SM-3P5ZB GTEx Tissue Sample Gene Expression Profiles 1.0 1.0165 YY1 JASPAR Predicted Transcription Factor Targets 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A43B-01A-81R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Infralimbic area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08103 H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TCF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.9751 CBLL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55711 Sarcoma_SARC_TCGA-DX-A3UE-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.08533 EAF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14492 KNSTRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87021 Infralimbic area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35649 Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-06A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WBP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.47311 FLII CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41768 NUDT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80163 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.042 cytoplasmic GeneRIF Biological Term Annotations 1.0 null GPRASP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60899 GTEX-S4Z8-2026-SM-3K2A9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07795 HEB MotifMap Predicted Transcription Factor Targets 1.0 null Anteromedial visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.40468 ASB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43285 Perturb_8462_KO_IFNLR1_ERP121014 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.97977 PATZ1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 190.954 CS+ DGIdb Drug Targets 2026 1.0 0.945214 Lassa Fever Virus_24hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 3.0507 GTEX-OOBK-0226-SM-2YUMF GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 GTEX-PW2O-0008-SM-48TEB GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 MAJIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70716 PIP5K1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68956 Acute Myeloid Leukemia_LAML_TCGA-AB-2932-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH1623 CCLE Cell Line Gene CNV Profiles 1.0 2.23556 GTEX-NL3H-0011-R6a-SM-2I3G8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.979299 GTEX-NL3H-0011-R1a-SM-48TDJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.01518 ARRDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10798 COR-L47 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.55417 FAM177A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73679 KDM4A ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4730-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTBP2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100455_FWM_dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.33076 GTEX-N7MT-0011-R6a-SM-2I3G3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.909111 KIF17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8261 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NN-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057558 GSE80098,GSE80366_0_v_6_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X585-0011-R6A-SM-46MVJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.21851 HCC2302 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.7978 H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ovary_6b HPA Tissue Sample Gene Expression Profiles -1.0 -1.08726 PMC9894241-pnas.2211429119.sd05.xlsx-G6_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null GTEX-X5EB-0008-SM-46MU3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69784 H3K27me3_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_K27me3_17603471_mouseNPC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null RPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16936 GSE96649_1_v_0_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null TFAP2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 166.287 GABA-A receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.038 POU5F1-18358816-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null pterigoid muscle trigeminal motor cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30633 GSE206729_2_v_0_trps1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-NL3H-0011-R10A-SM-2I3E9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.54909 Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.022 FAM98C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.96323 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_7254_KO_MBD1/MBD2/MBD4/MECP2_SRP337936 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.20342 GTEX-S7SF-0008-SM-3NM8T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11756 H1-7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99308 CRLS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7971 CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null upper (rostral) rhombic lip_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00356 GSE142210_11_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null testis_7a HPA Tissue Sample Gene Expression Profiles 1.0 1.11316 H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CB-49-OG36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.506105 Prostate adenocarcinoma_PRAD_TCGA-HC-7231-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null THP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.46389 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3MA-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAD21_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AG-0426-SM-2S1PU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13379 UACC-893 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.05508 MCMBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51172 HOXB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94591 cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.915965 H3K4me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SOX3-22085726-MUSCLE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE110580_1_v_0_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S32W-0526-SM-4AD6F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.889982 ECC10 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE173873_2_v_11_stra8_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27me3_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCIH2882 DepMap CRISPR Gene Dependency 1.0 4.9984 PMC8986528-41586_2022_4598_MOESM6_ESM.xlsx-Fig_4h-LAS1L_KD_upreg_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE146962_0_v_1_glucosamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE192689_0_v_2_ricin_mouse RummaGEO Drug Perturbation Signatures -1.0 null ventrolateral part of isA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66057 medial part of r5B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21045 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VASH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57152 C22orf23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73006 CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-175 COSMIC Cell Line Gene Mutation Profiles 1.0 null membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 TC32 CCLE Cell Line Gene Expression Profiles 1.0 1.81468 RHEB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.06381 H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.40892 mammalian phenotype MPO Gene-Phenotype Associations 1.0 null Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.041 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4735-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BCL2L10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84519 lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36775 SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.24379 COMMD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68248 PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S8-DUX4_SpecDMCs-Unnamed_3_DUX4 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02283 GTEX-NFK9-0626-SM-2HMIV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.901321 EVSAT DepMap CRISPR Gene Dependency 1.0 3.43255 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.824604 NRF2-20460467-MEF-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Potassium Channels Reactome Pathways 2014 1.0 null GTEX-WFG8-0008-SM-4LVN6 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 GTEX-QDT8-0011-R7A-SM-32PKF GTEx Tissue Sample Gene Expression Profiles 1.0 1.0618 H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NFKB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.0763 hsa-miR-3678-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.09606 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JC-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19316 hsa-miR-4723-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QVJO-0011-R5A-SM-2S1QM GTEx Tissue Sample Gene Expression Profiles 1.0 1.12038 GSE169205_4_v_7_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4TJ-01A-51R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF37A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23222 ATP6V0E1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02748 transferase activity, transferring phosphorus-containing groups GO Molecular Function Annotations 2015 1.0 null ACHN CCLE Cell Line Gene CNV Profiles 1.0 1.86466 RAD21_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041262 RPS25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3174 GSE147876,GSE147877_4_v_6_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null RPL23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64262 Chodhfr TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.837 AOB, internal plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76318 ILKAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74303 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A556-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058597 GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles 1.0 0.846554 gp120 GeneRIF Biological Term Annotations 1.0 null TBC1D9B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06743 H3K9me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WCDI-0008-SM-47JYE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.905121 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormal spatial reference memory MGI Mouse Phenotype Associations 2023 1.0 null GTL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.929678 Rectum adenocarcinoma_READ_TCGA-DY-A1H8-01A-21R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.845269 CCNT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7535 GTEX-WH7G-0008-SM-4LVNM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41581 GTEX-WZTO-0011-R7B-SM-4E3IS GTEx Tissue Sample Gene Expression Profiles 1.0 0.983889 RIOK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4741 PMC4362528__F8 PFOCR Pathway Figure Associations 2023 1.0 null HS939T CCLE Cell Line Gene Expression Profiles -1.0 -1.89428 RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHSE-0011-R4A-SM-3P5ZN GTEx Tissue Sample Gene Expression Profiles 1.0 1.26649 CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GID4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47758 Perturb_16962_KD_PAX2_SRP044867 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null PTPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31049 SOX11-22085726-ESNS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null FE-10-KQ78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.249853 Perturb_11716_KD_GATAD2A_SRP194625 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.11331 NFILZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33012 ZNF227 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20543 GB-73-QS80_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.321855 GTEX-QDT8-0011-R1A-SM-32PKS GTEx Tissue Sample Gene Expression Profiles 1.0 1.24931 H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE87412,GSE92423_3_v_4_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null icSARS-Cov_Day2_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.90839 GTEX-UTHO-0008-SM-4JBID GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13123 GTEX-QVUS-0011-R10A-SM-3GIK3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.036 GSE146612_1_v_0_amiodarone_human RummaGEO Drug Perturbation Signatures -1.0 null UGP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39588 HOXD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39323 NCI-H2347 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.896328 Brain Lower Grade Glioma_LGG_TCGA-FG-A4MT-02A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P4PP-1726-SM-2S1NS GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 trunk TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063146 Lateral entorhinal cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.064 GSE119498_0_v_10_setd5_mouse RummaGEO Gene Perturbation Signatures 1.0 null SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rara_21299862_mcf7_lof_human__gds4065 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.157462 GTEX-X4XX-0011-R1B-SM-3P622 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09364 MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18499 RCOR3 ChEA Transcription Factor Targets 1.0 null H3K27me3_cardiac mesoderm_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null Specific developmental disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.556 NUGC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11946 liminal part of alar isthmus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66057 HUPT3 CCLE Cell Line Gene CNV Profiles -1.0 -2.0309 abnormal learning/memory/conditioning MPO Gene-Phenotype Associations 1.0 null NCI-H2795 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.98978 H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_1_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null RPL34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.94626 Avoidant personality disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.054 Pierpont syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.804 regulation of cellular process GO Biological Process Annotations 2015 1.0 null an3ca HPA Cell Line Gene Expression Profiles 1.0 1.13672 WM2664 CCLE Cell Line Gene CNV Profiles -1.0 -1.34054 nonconvulsive seizures MGI Mouse Phenotype Associations 2023 1.0 null METTL27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.07377 PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null MAPK9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63748 Brain Lower Grade Glioma_LGG_TCGA-HT-7880-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CBX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87273 C6orf132 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84766 intermediate stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44849 GSE87412,GSE92423_0_v_4_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null GC-04-UF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.218259 GSE195568_2_v_4_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PVOW-0011-R1A-SM-32PL6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.33226 H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Developmental disorder of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.426 GTEX-N7MS-0011-R6a-SM-2HMJ4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.19802 plasma membrane part GO Cellular Component Annotations 2015 1.0 null PPP1R2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.663 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LA-42-ER00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.256689 ATG2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40988 GTEX-N7MT-0011-R5a-SM-2I3G6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.971446 H3K27ac_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KLF4-18358816-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null integral component of plasma membrane GO Cellular Component Annotations 2015 1.0 null GTEX-WZTO-3026-SM-3NMA2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24852 OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.877061 PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Unnamed_12_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null Main olfactory bulb, outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21634 GTEX-XOTO-2126-SM-4B64U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46632 Brain Lower Grade Glioma_LGG_TCGA-WY-A859-01A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12318984-Table1.xlsx-S7-Table_S7_Instrumental_variables_IVs_identified_from_eQTL_dataset_for_druggable_GIKs_used_in_Mendelian_randomization_MR_analysis_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null CHGB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34995 8505C CCLE Cell Line Gene Expression Profiles -1.0 -1.98035 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45975 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE144115_4_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-146b-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.111118 LYAR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0653 GSE146982_7_v_1_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WWYW-3126-SM-3NB39 GTEx Tissue Sample Gene Expression Profiles 1.0 2.20705 496100346_FWM_no dementia_TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.04388 TRAM1L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14098 skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -0.985815 head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.551695 CXCR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75403 Nrf-2 MotifMap Predicted Transcription Factor Targets 1.0 null PIGO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88012 ESO51 DepMap CRISPR Gene Dependency 1.0 3.35982 GSE228106_3_v_4_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null Long QT syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.55 Potassium channel, voltage-dependent, ELK InterPro Predicted Protein Domain Annotations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8018-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE226316_6_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE132694,GSE132717_0_v_2_meis1_human RummaGEO Gene Perturbation Signatures -1.0 null regulation of transmembrane transport GO Biological Process Annotations 2015 1.0 null hematopoietic stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069782 NCC010 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE87412,GSE92423_2_v_1_dnmt3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null P3H4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67034 regulation of ion transport GO Biological Process Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-A4D0-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RVPU-0011-R3A-SM-2XCAE GTEx Tissue Sample Gene Expression Profiles 1.0 0.827605 SP1 JASPAR Predicted Transcription Factor Targets 1.0 null r8 part of linear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.77368 Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QW-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBF1/2-26484160-CHIP-SEQ-HMEC-DERIVED-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Perturb_8046_KD_MCRS1_SRP103083 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.8384 GSE235701,GSE261434_0_v_3_enasidenib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Supplementary_Table_2B_Contrast_ATF4-def_DMSO_2h_vs_HCT116_DMSO_2h_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null TOR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81921 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BS-01A-21R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZNF445 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15565 Lung adenocarcinoma_LUAD_TCGA-55-6968-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE217378_2_v_0_lin28b_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_2_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null HDAC2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE126345_2_v_5_hcrt_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE192860_0_v_1_trifluoperazine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE131673_0_v_1_arid1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null ligand-gated monoatomic cation channel activity GO Molecular Function Annotations 2025 1.0 null GTEX-WVLH-2926-SM-3MJG5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.856448 TCF3_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-668 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.923971 EZH2_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44375 GSE145430_0_v_1_zmat3_mouse RummaGEO Gene Perturbation Signatures 1.0 null MINDY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.09419 bronchus HPA Tissue Protein Expression Profiles 1.0 0.882435 synovial sarcoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.685491 NAGS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41101 hsa-miR-1236 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 rectum_8a HPA Tissue Sample Gene Expression Profiles -1.0 -0.830762 biological_process GO Biological Process Annotations 2015 1.0 null H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Anterior olfactory nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0908 EBF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.9401 internal female genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052626 eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE153443_1_v_2_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_1_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null FA-80-DR66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.204528 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE235066_7_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null C75 DepMap CRISPR Gene Dependency 1.0 2.827 HCC12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04403 GSE202434,GSE202438_10_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null CD24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7951 CDY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43687 H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MMAB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23527 Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKM1 CCLE Cell Line Gene CNV Profiles -1.0 -2.00526 layer I of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19764 EJM DepMap CRISPR Gene Dependency 1.0 2.196 Atherosclerosis_Aorta Smooth Muscle Tissue_GSE1560 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.69492 abnormal object recognition memory MPO Gene-Phenotype Associations 1.0 null MJ DepMap CRISPR Gene Dependency 1.0 2.32614 side of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.147746 Brain Lower Grade Glioma_LGG_TCGA-HT-8015-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052548 GSE247862,GSE247863_2_v_1_eomes_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-PJ-A5Z9-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE90552_1_v_0_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Skin - Not Sun Exposed (Suprapubic) GTEx Tissue Gene Expression Profiles 2023 1.0 3.13344 Perturb_2133_KD_HAPSTR1_SRP377309 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.71982 MTA3 ENCODE Transcription Factor Targets 1.0 null GTEX-TMMY-0008-SM-4DXU3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.871243 astrocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06827 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4873-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042058 CTTNBP2NL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0107 isthmic part of the intermediate lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66649 layer III of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.98747 RPS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59842 GTEX-PVOW-2726-SM-48TCA GTEx Tissue Sample Gene Expression Profiles 1.0 1.33573 ZNF530 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 90.3579 H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Potassium channel, voltage-dependent, EAG/ELK/ERG InterPro Predicted Protein Domain Annotations 1.0 null SC5D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44441 AOB, mitral cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71547 GTEX-T5JC-0011-R1A-SM-32PM6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.65415 Anterior cingulate area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13269 JD-44-KF86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.376911 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.02906 CB-31-UO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.534966 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null substrate-specific channel activity GO Molecular Function Annotations 2015 1.0 null AC-84-QG99_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.313768 PMC8494348-pone.0257161.s002.xlsx-only_D20_-_OXT_NOT_ext-Gene_Name_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100317_FWM_no dementia_no TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.21839 EEF2KMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37285 SLC29A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49876 KDELR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53265 ZIC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 85.5282 Adrenocortical carcinoma_ACC_TCGA-OR-A5L3-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NB1 DepMap CRISPR Gene Dependency 1.0 5.3338 extrinsic component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.344556 SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null increased circulating free fatty acids level MGI Mouse Phenotype Associations 2023 1.0 null H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Autism spectrum disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.235 PMC12079334-ADVS-12-2501734-s002.pdf-128-ENSG00000189079_ARID2 Rummagene Transcription Factor Associations 2026 1.0 null NLRP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13659 GSE205163,GSE205164_1_v_7_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null hel HPA Cell Line Gene Expression Profiles -1.0 -1.15888 CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIM68 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10868 GTEX-X585-3026-SM-46MWF GTEx Tissue Sample Gene Expression Profiles 1.0 2.20055 Attention Deficit Disorder DisGeNET Gene-Disease Associations 1.0 null CTCF_GM10248_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral ventricle HPA Tissue Protein Expression Profiles -1.0 -1.18682 19658189-TableS8d GeneSigDB Published Gene Signatures 1.0 null GSE245407,GSE245412_0_v_1_smurf1_human RummaGEO Gene Perturbation Signatures 1.0 null single organism signaling GO Biological Process Annotations 2015 1.0 null EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE206984_1_v_0_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null Neuron projection membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.714 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.975833 UBTF ENCODE Transcription Factor Targets 1.0 null H3K9ac_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null IMR-32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25244 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.23492 CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Vitelline membrane TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.054 dorsal thalamus_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.831963 CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19316 NAA30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39218 Liver hepatocellular carcinoma_LIHC_TCGA-DD-AA3A-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM20B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30434 PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-12q13_11_TP63 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-N7MT-0011-R4a-SM-2I3G9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.837549 GTEX-R53T-0008-SM-48FEW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.855198 GSE222598_1_v_0_sf3b4_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_13054_OE_HDAC4_SRP334442 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -19.3979 GTEX-NPJ7-2926-SM-3MJGQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.925561 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NH-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ADAM11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69176 TMEM106A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18725 H4K20me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CCNF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89472 brain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.492182 venom gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.915642 GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.831794 MMP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.76019 HDAC1 ENCODE Transcription Factor Targets 1.0 null posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.14396 Schizophrenia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.42 GTEX-NPJ7-0011-R10A-SM-2I3E5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08758 SP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 111.174 H3K27me3_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE103297_1_v_0_glis3_mouse RummaGEO Gene Perturbation Signatures 1.0 null ELF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10673 GSE134375_4_v_2_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null RNF2-27304074-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE134375_0_v_5_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null Primary somatosensory area, unassigned, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55748 H3K27me3_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF789 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91925 Perturb_7134_KD_NRSF_SRP261089 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.84567 GSE185519_4_v_7_gilteritinib_human RummaGEO Drug Perturbation Signatures -1.0 null TOPORS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74634 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Mitral cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.541 IPO9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02977 GTEX-RVPU-0008-SM-3NM8B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04071 Cesium CTD Gene-Chemical Interactions 1.0 null ARX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24474 inner SZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.3995 SRI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41522 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3R3-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Barium CTD Gene-Chemical Interactions 1.0 null intrinsic component of plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 Perturb_308_KD_ALKBH3_SRP398078 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.45178 PER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52683 RmlC-like jelly roll fold InterPro Predicted Protein Domain Annotations 1.0 null GTEX-S7SE-0011-R1A-SM-2XCDE GTEx Tissue Sample Gene Expression Profiles 1.0 1.11169 AF-41-QY60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.209804 GSE241701_2_v_3_daxx_mouse RummaGEO Gene Perturbation Signatures 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N7-A59B-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.055685 mRNA_MEF2C_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-WWYW-0011-R1A-SM-3TW8G GTEx Tissue Sample Gene Expression Profiles 1.0 1.61481 Mesothelioma_MESO_TCGA-LK-A4O2-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE142430_2_v_1_prmt5_human RummaGEO Gene Perturbation Signatures -1.0 null Anterior cingulate area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18222 Potassium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.658 Pulmonary artery endothelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.641 ChIP_NACC1_18358816 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null protein histidine kinase activity GO Molecular Function Annotations 2015 1.0 null LOVO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18869 monoatomic cation transmembrane transport GO Biological Process Annotations 2023 1.0 null KCNK15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00196 abnormal behavioral response to xenobiotic MPO Gene-Phenotype Associations 1.0 null H3K4me1_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18076 Neuronal System Reactome Pathways 2014 1.0 null OXER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71094 intracellular signal transduction GO Biological Process Annotations 2015 1.0 null GTEX-XOTO-0011-R7B-SM-4B64R GTEx Tissue Sample Gene Expression Profiles 1.0 1.18745 central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CEP135 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8198 RYK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87796 Acute Myeloid Leukemia_LAML_TCGA-AB-2851-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R55F-0011-R6A-SM-2TF4L GTEx Tissue Sample Gene Expression Profiles 1.0 0.973657 CAOV4 Achilles Cell Line Gene Essentiality Profiles 1.0 1.5025 Lung adenocarcinoma_LUAD_TCGA-55-8620-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WZTO-0011-R10B-SM-4E3KB GTEx Tissue Sample Gene Expression Profiles 1.0 1.73455 absence seizures MPO Gene-Phenotype Associations 1.0 null MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.856995 caudal ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.41723 KMS34 CCLE Cell Line Gene CNV Profiles 1.0 1.74594 GTEX-RVPV-0011-R3A-SM-2TF63 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2441 H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P44H-0011-R8A-SM-2XCEL GTEx Tissue Sample Gene Expression Profiles 1.0 0.861785 ZNF320 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 197.515 TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_1_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null GSE166783_8_v_2_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null SCOC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.30805 DLD-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.48331 Mathematical Ability DisGeNET Gene-Phenotype Associations 1.0 null NACC1-18358816-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A634-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_3754_KD_RNF40_ERP110773 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 A427 COSMIC Cell Line Gene Mutation Profiles 1.0 null KLHL11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.41525 STAT6 MotifMap Predicted Transcription Factor Targets 1.0 null protein kinase activity GO Molecular Function Annotations 2015 1.0 null CHAGO-K-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null PRSS50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89655 19658189-TableS4 GeneSigDB Published Gene Signatures 1.0 null Rumen epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.9 CCNT2 ENCODE Transcription Factor Targets 1.0 null GTEX-QLQ7-0008-SM-447AW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13332 H3K27me3_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LF-01A-21R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAFK ENCODE Transcription Factor Targets 1.0 null TAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01718 E2F6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 87.6919 RNF24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.60827 Pulmonary artery endothelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.615 PMC2665242-gkp077_nar-02582-s-2008-File009.xls-Supple_Table3_CTCF-Unnamed_4_CTCF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-R55E-0011-R5A-SM-2TC5N GTEx Tissue Sample Gene Expression Profiles 1.0 1.11318 PMC8755441-mmc3.xlsx-IRF7-Up-SUZ12_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WWYW-0011-R5A-SM-3NB3E GTEx Tissue Sample Gene Expression Profiles 1.0 1.0416 DU4475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.06705 Perturb_6866_KO_CDK8/CDK19_SRP299261 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 PMC7203476-Table_2.XLSX-MI_treat_vs_control-Unnamed_0_MITF Rummagene Transcription Factor Associations 2026 1.0 null Glomerular layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.803 KASUMI1 DepMap CRISPR Gene Dependency 1.0 3.01274 GTEX-NPJ8-0011-R10A-SM-2YUMO GTEx Tissue Sample Gene Expression Profiles 1.0 1.55841 HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.96896 periventricular stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51372 GSTP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87093 GTEX-XUW1-0008-SM-4BOQH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11593 POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal thalamus_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.91843 inorganic ion transmembrane transport GO Biological Process Annotations 2015 1.0 null KCNC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08389 Perturb_11424_KD_KIF4A_SRP324259 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SP2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 129.079 Posterior paraventricular nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.03 GTEX-RU1J-0008-SM-46MV9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.909906 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PSDG-0426-SM-2S1OF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858615 nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.594451 SUM185PE DepMap CRISPR Gene Dependency 1.0 2.32619 INO80B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74285 GTEX-QVJO-0011-R1A-SM-2S1QI GTEx Tissue Sample Gene Expression Profiles 1.0 1.25074 HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.826955 GTEX-PWOO-2226-SM-2S1P1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23951 H3K4me3_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null OB-06-WW76_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.250752 Pervasive developmental disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.221 CDK5R1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48759 SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07826 CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE146982_0_v_6_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null MDAMB453 Achilles Cell Line Gene Essentiality Profiles 1.0 2.67887 HC-01-FD24_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.320417 Perturb_375_KD_DHX16_SRP309315 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.42416 GTEX-T2IS-0011-R11A-SM-32QPC GTEx Tissue Sample Gene Expression Profiles 1.0 0.898102 Bone marrow endothelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.887 NIPSNAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0583 Interneuron-selective cell_Brain_Mouse CellMarker Gene-Cell Type Associations 1.0 null SOD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22567 H3K27me3_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null behaviors GeneRIF Biological Term Annotations 1.0 null A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.4685 molecular layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15441 abnormal long-term potentiation MGI Mouse Phenotype Associations 2023 1.0 null H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SSA3-0226-SM-32QPN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.856259 Disease of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.556 Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.157 NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION ChEA Transcription Factor Targets 2022 1.0 null GTEX-Q2AG-0011-R4A-SM-2HMKA GTEx Tissue Sample Gene Expression Profiles 1.0 1.63226 Acute Myeloid Leukemia_LAML_TCGA-AB-2973-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT-483 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.94069 PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC Rummagene Transcription Factor Associations 2026 1.0 null GSE217873_1_v_0_nusap1_human RummaGEO Gene Perturbation Signatures -1.0 null Nucleus solitarius TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.832 H3K27me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary hematopoietic stem cells G-CSF-mobilized Female RO_01536 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.87184 ACADVL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13444 PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.50026 FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.251081 Intellectual disability DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.057 Somatomotor areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10108 GTEX-OXRN-2426-SM-2I5EQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.42094 GA-88-CF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.280863 membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.051385 GTEX-W5X1-1426-SM-3GIKH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 bone marrow cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06696 ABCB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6962 metal ion transport GO Biological Process Annotations 2015 1.0 null Autistic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.154 KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.931989 SRC_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null TE6 CCLE Cell Line Gene CNV Profiles 1.0 1.32763 SP5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 63.5945 E2F4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11386 ACSL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12254 other GAD High Level Gene-Disease Associations 1.0 0.293278 pineal_night BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.41871 potassium ion transport GO Biological Process Annotations 2025 1.0 null H3K4me3_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-91-6828-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mesothelioma_MESO_TCGA-LK-A4O6-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CA1 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.20282 MAFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19648 decreased single cell response threshold MPO Gene-Phenotype Associations 1.0 null Paranode region of axon COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.898 SLC52A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49491 TMEM68 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64483 cerebellar cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00824 H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ACHN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.847911 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Unnamed_2_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LRRC8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45431 E2F6 ENCODE Transcription Factor Targets 1.0 null TBL1-22424771-293T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null hippocampus (hippocampal formation)_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.999309 GSE124920_1_v_2_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RVPU-0011-R10A-SM-2XCAH GTEx Tissue Sample Gene Expression Profiles 1.0 1.06337 GSE148066,GSE157787_11_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SLC35A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.06045 Fetal_Brain_Female Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.50683 nerve TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.365633 GSE60217_1_v_0_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null GLCCI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58724 APBB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21234 SEPTIN11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31886 RS4-11 COSMIC Cell Line Gene Mutation Profiles 1.0 null catalytic activity GO Molecular Function Annotations 2015 1.0 null GTEX-NL4W-0011-R10A-SM-2I3DY GTEx Tissue Sample Gene Expression Profiles 1.0 1.1384 Sarcoma_SARC_TCGA-MJ-A850-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ChIP_KLF4_18358816 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-PWN1-0226-SM-2S1OZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 HMY1 DepMap CRISPR Gene Dependency 1.0 3.20316 GTEX-QMR6-1426-SM-32PLA GTEx Tissue Sample Gene Expression Profiles 1.0 1.68698 GSE166783_3_v_2_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null GNRH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66869 RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.957457 ZBTB44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83191 GTEX-UTHO-0011-R5A-SM-3GIJD GTEx Tissue Sample Gene Expression Profiles 1.0 1.00135 PARP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21377 ATRFLOX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.29709 MEWO COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTSD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.13223 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HT1197 DepMap CRISPR Gene Dependency 1.0 2.76343 H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CYB561A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4235 cerebellum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.882596 PROKR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10164 HT-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.19181 FBXW8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69278 GTEX-XOTO-0011-R5A-SM-4B657 GTEx Tissue Sample Gene Expression Profiles 1.0 0.862961 GTEX-X585-0011-R10A-SM-46MUY GTEx Tissue Sample Gene Expression Profiles 1.0 1.88625 GTEX-XLM4-0011-R7A-SM-4AT5L GTEx Tissue Sample Gene Expression Profiles 1.0 1.23512 KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.860277 ATP5MC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58589 Sarcoma_SARC_TCGA-PC-A5DL-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PKIG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75197 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null eGFP-GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ORC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47841 GSE117212,GSE117214_0_v_1_zbtb1_human RummaGEO Gene Perturbation Signatures -1.0 null NR0B1 ChEA Transcription Factor Targets 1.0 null neuroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.083413 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6868-01B-12R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null potassium ion transmembrane transport GO Biological Process Annotations 2023 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-96-A4JL-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.36772 Lung adenocarcinoma_LUAD_TCGA-91-6847-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE142210_9_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GNL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86045 small intestine HPA Tissue Protein Expression Profiles 1.0 0.882435 CDC14B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20345 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A185-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA3-27048872-CHIP-SEQ-THYMUS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PMC12717993-MEC-34-e17796-s002.xlsx-ST12_WGS_RFMix_genes_2_anc-Unnamed_14_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01036 TR146 DepMap CRISPR Gene Dependency 1.0 2.65639 GTEX-TKQ1-1426-SM-4GICK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.412 JARID1B-DAIN-22020125-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.52911 GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41677 GTEX-RNOR-2426-SM-48FDY GTEx Tissue Sample Gene Expression Profiles 1.0 1.29642 H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.04816 hematopoietic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051724 H3K4me1_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Primary somatosensory area, lower limb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31243 PMC2665242-gkp077_nar-02582-s-2008-File009.xls-Supple_Table3_CTCF-Unnamed_3_CTCF Rummagene Transcription Factor Associations 2026 1.0 null CLPP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57806 TUBB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77131 Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.449 H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WZTO-0011-R5B-SM-3NMC5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.15738 GTEX-S4Z8-0008-SM-33HAZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48128 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053785 DU4475 CCLE Cell Line Gene Expression Profiles 1.0 1.4938 RNF166 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.10858 GTEX-TMZS-0008-SM-47JWM GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 Perturb_12599_KD_Gatad2b_SRP366371 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 8.47967 rostral zona incerta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14303 H4K20me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SUZ12 ENCODE Transcription Factor Targets 1.0 null TFDP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.0264 BRD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55349 PPP1R13B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42087 GTEX-T5JC-0011-R8A-SM-32PLM GTEx Tissue Sample Gene Expression Profiles 1.0 1.85077 brain_3b HPA Tissue Sample Gene Expression Profiles 1.0 1.27879 H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WRHK-0005-SM-3MJF5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.937301 PUS7L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8546 C22orf15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7588 integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE210885_5_v_6_klf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_GM12869_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE96649_1_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null decreased single cell response threshold MGI Mouse Phenotype Associations 2023 1.0 null hippocampus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.648938 GTEX-PLZ6-0008-SM-48TD5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41014 GTEX-QXCU-0226-SM-2TC5W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40211 GSE231648_4_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null immunoglobulin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.174911 LSM14B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95933 SP in entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46588 regulation of biological quality GO Biological Process Annotations 2015 1.0 null cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.239799 AMIFAMPRIDINE DGIdb Drug Targets 2026 1.0 0.180041 ATP5MGL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33349 MFSD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06264 REST ENCODE Transcription Factor Targets 1.0 null H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-125a-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.082179 Primary somatosensory area, barrel field, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05747 SLR21 CCLE Cell Line Gene Expression Profiles 1.0 1.47949 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36692 Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE139540_4_v_1_menadione_human RummaGEO Drug Perturbation Signatures -1.0 null DA-66-OE69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.642153 GSE101239_4_v_2_valproic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null NHLH2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 81.3436 GSE168401_2_v_0_harmine_human RummaGEO Drug Perturbation Signatures 1.0 null Posterior parietal association areas, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14413 NDRG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53593 LAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99289 H3K4me3_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null stratum radiatum of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.7047 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CGTHW1 CCLE Cell Line Gene CNV Profiles -1.0 -1.87094 EPHA4_knockout_227_GSE34430 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.18043 GSE146982_0_v_6_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE187006_3_v_1_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE122067_2_v_1_mtch2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4819-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE76425_0_v_12_lenalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null regulation of membrane potential GO Biological Process Annotations 2015 1.0 null UACC-257 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.835754 PES1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30078 KLF5-25053715-YYC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ChIP_SUZ12_18692474 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null MPDZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75089 ventrolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.827319 cerebral hemisphere TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.487886 CBX2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 H3K27me3_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LYPD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63665 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Perturb_18031_KO_Dnmt3b_SRP201807 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.76382 GTEX-X4XX-0011-R6B-SM-46MWP GTEx Tissue Sample Gene Expression Profiles 1.0 1.05986 brain cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.089907 H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Huntington's Disease_CNS - Brain - Striatum (MMHCC)_GSE9857 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -3.40255 H4K20me1_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.8061 metabolic process GO Biological Process Annotations 2015 1.0 null HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10431 VZ in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.69112 APPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92487 CADOES1 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.18303 GSE240645_1_v_0_u90926_mouse RummaGEO Gene Perturbation Signatures -1.0 null adult stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063098 GSE226316_1_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null LANCL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17634 GSE195663_0_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null PCDHB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17642 H3K9me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null TET2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.54241 EZH2_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null muscle GTEx Tissue Gene Expression Profiles -1.0 -0.980885 EB2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.90265 H3K27ac_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KE97 CCLE Cell Line Gene CNV Profiles 1.0 1.34207 GSE111102,GSE111105_4_v_0_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null DF-00-BU08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.40613 GSE148692,GSE148695_5_v_3_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null intermediate stratum of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22004 PPM1D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22435 GTEX-XOTO-3026-SM-4B65M GTEx Tissue Sample Gene Expression Profiles 1.0 1.93862 GSE42805,GSE42811_2_v_3_cocaine_mouse RummaGEO Drug Perturbation Signatures 1.0 null Perturb_14311_OE_CD83_SRP178846 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -7.90716 MAFK_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DCAKD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12397 GSE142684_3_v_5_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE154074_1_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null REST-19997604-NEURONS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TSPAN31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72143 BNC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4093 cbfb_19800266_t_reg_lof_mouse_gpl1261_gds3577 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.137818 NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.982781 PAS domain InterPro Predicted Protein Domain Annotations 1.0 null GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12363 GSE119498_2_v_4_setd5_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE154074_1_v_4_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-N7MS-0011-R5a-SM-2HMK8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.19478 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CD56+_NKCells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.35583 AC-74-ZA35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.50437 UBTF_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AB-09-EA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.263621 Venom apparatus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.817 MEF2A-21415370-HL-1-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Z8-1826-SM-3K2BH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17169 GSE219195_0_v_5_rbm12_human RummaGEO Gene Perturbation Signatures 1.0 null GB-73-QS80_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.282113 H3K27me3_cardiac mesoderm_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.868456 IGFBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60842 A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_2day-MOI-10^3_None_GSE43302 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.82556 GSE169617_1_v_2_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27me3_H7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null gated channel activity GO Molecular Function Annotations 2015 1.0 null GTEX-PX3G-0008-SM-48U2L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1266 CD1D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64559 salivarygland_6c HPA Tissue Sample Gene Expression Profiles 1.0 0.879492 single-organism process GO Biological Process Annotations 2015 1.0 null SRSF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5768 SP8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 86.3654 GTEX-WH7G-0426-SM-3NMBJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17509 intermediate (interpositus) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11867 heterotrimeric g-protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.463198 ZBTB7A ENCODE Transcription Factor Targets 1.0 null LS180 CCLE Cell Line Gene Expression Profiles -1.0 -2.20281 potassium ion transmembrane transport GO Biological Process Annotations 2025 1.0 null GTEX-QDVJ-0008-SM-48U2E GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 ELF1 ENCODE Transcription Factor Targets 1.0 null MIA PACA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19435 FECH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81011 CTCF_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null parathyroid gland HPA Tissue Protein Expression Profiles 1.0 0.882435 Perturb_10359_KD_Ascl1_SRP340223 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GSE146982_4_v_2_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null C3orf18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45239 Primary somatosensory area, lower limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38688 FAM83H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59214 VZ in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13502 CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null YWHAQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.1702 RARA::RXRG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.7453 CL11 CCLE Cell Line Gene Expression Profiles -1.0 -1.77025 H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CB-16-SY72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.238082 GTEX-WK11-2526-SM-3NM9Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.917455 PIWIL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29146 GTEX-W5WG-2326-SM-3GIJH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71907 Lung adenocarcinoma_LUAD_TCGA-44-7669-01A-21R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KM12 COSMIC Cell Line Gene Mutation Profiles 1.0 null Streptococcal tonsillitis_Tonsillar Lymphoid Tissue_GSE11494 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.5533 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1YY-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null blood TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052006 H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_14211_KO_Sp8/Sp9_SRP084329 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 NOCT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07674 Orbital area, medial part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46626 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null U-937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.859754 medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.53996 SIN3B-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Supplementary_Table_2C_Contrast_ATF4-def_DMSO_8h_vs_HCT116_DMSO_8h_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null FLO-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null ChIP_H3K9me3_19884255_mouseESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4352-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARHGAP12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.89471 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null inward rectifier potassium channel activity GO Molecular Function Annotations 2025 1.0 null GSE149035_3_v_5_hepacam_human RummaGEO Gene Perturbation Signatures -1.0 null LA-42-ER00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.250266 GSE214823,GSE214824_0_v_1_crtc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2985-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPB-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null DE-28-BW67_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.202233 medial subhabenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34697 SMO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98382 protein binding GO Molecular Function Annotations 2015 1.0 null TACC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29384 Perturb_12493_KD_ELK3_SRP361792 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 ZFX_KO_GDS2718_151_mouse_hematopoietic stem cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null seminal vesicle HPA Tissue Protein Expression Profiles 1.0 0.882435 NCIH1385 CCLE Cell Line Gene CNV Profiles 1.0 1.50678 cation channel activity GO Molecular Function Annotations 2015 1.0 null gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052248 FABP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90457 TJP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95041 signal transduction by phosphorylation GO Biological Process Annotations 2015 1.0 null MEF2A ChEA Transcription Factor Targets 1.0 null GTEX-X585-0011-R5A-SM-46MVI GTEx Tissue Sample Gene Expression Profiles 1.0 1.20157 GRM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79193 EIF3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38894 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IH-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_6843_KD_E2F1_SRP238361 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 HNRNPK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33537 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_2_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null Primary somatosensory area, unassigned, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23072 TRAF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33944 GTEX-T5JC-2326-SM-32PMR GTEx Tissue Sample Gene Expression Profiles 1.0 1.04186 Perturb_11423_KD_AR_SRP324259 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.047546 primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.955483 H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUZ12 ChEA Transcription Factor Targets 1.0 null ZXDB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38896 H3K27me3_mononuclear cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OAW42 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11329 mantle zone of IC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0081 C99 DepMap CRISPR Gene Dependency 1.0 5.09144 GTEX-X4XX-0011-R4B-SM-46MWL GTEx Tissue Sample Gene Expression Profiles 1.0 0.891969 GTEX-U8XE-0726-SM-3DB8O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24481 H3K36me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS34 DepMap CRISPR Gene Dependency 1.0 2.27393 GSE174383_4_v_0_ly6d_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Supplementary_Table_2A_Contrast_ATF4-def_control_vs_HCT116_control_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null Primary somatosensory area, trunk, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63115 potassium ion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null ICAM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30406 GTEX-X4EP-3226-SM-3P5YR GTEx Tissue Sample Gene Expression Profiles 1.0 0.943629 GTEX-R3RS-0008-SM-48FF1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.958554 Primary somatosensory area, trunk, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44589 GTEX-RNOR-0011-R4A-SM-3GAD3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.40038 Perturb_6865_KO_CDK8/CDK19_SRP299261 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Perturb_5768_KO_Sip1/Nkx21_SRP010804 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 Orbital area, lateral part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14331 GSE210885_2_v_4_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null Accessory olfactory bulb, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.02476 skbr3 HPA Cell Line Gene Expression Profiles -1.0 -1.15888 Brain Lower Grade Glioma_LGG_TCGA-FG-A713-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ANP32B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33643 PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-1434_proliferation_genes-ZNF766_ZNF766 Rummagene Transcription Factor Associations 2026 1.0 null ZNF263 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.5455 DBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59702 IPPK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22585 GTEX-UTHO-2926-SM-3P5Z9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.859044 Perturb_9209_KO_Cic_SRP076421 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.11824 C2orf15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92296 H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19435 KYAE-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null PHC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82962 alar plate of m1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01491 NCI-H2171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14179 Brain Lower Grade Glioma_LGG_TCGA-TM-A7CF-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ORAI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27498 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A197-06A-32R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null ACSS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99309 FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1155 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null SLC25A34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84461 voltage-gated potassium channel activity GO Molecular Function Annotations 2015 1.0 null SNU46 DepMap CRISPR Gene Dependency 1.0 2.04176 Chronic wasting disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.427 collicular (rostral) midbrain tectum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01717 OSBPL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49839 MYOG_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null primary bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.049354 GSE196117_1_v_7_clarithromycin_human RummaGEO Drug Perturbation Signatures 1.0 null NCIH889 CCLE Cell Line Gene Expression Profiles 1.0 1.55799 Mucolipidosis type IV DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.103 SK-N-FI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37077 Orbital area, lateral part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00931 SU8686 Achilles Cell Line Gene Essentiality Profiles 1.0 1.07762 zona incerta complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14026 S0-EE-Y7IR_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.301054 ng-108-15 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.692902 SAP30 ENCODE Transcription Factor Targets 1.0 null ZBTB7A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.5218 ALX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60578 GSE146982_4_v_1_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null PMC4362528__F8 PFOCR Pathway Figure Associations 2024 1.0 null GSE100316_7_v_1_mtor_mouse RummaGEO Gene Perturbation Signatures 1.0 null KRTCAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3673 skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -1.09385 PIP5K1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26818 GSE149901_3_v_1_anlotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-N7MS-0011-R1a-SM-2HMJG GTEx Tissue Sample Gene Expression Profiles 1.0 0.900823 REDD1_Repression_GDS3558_73_human_Blood Myeloid Cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Purkinje cell layer of CbVCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16609 Orbital area, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03588 PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Baboon_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE76425_0_v_5_lenalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null Retrosplenial area, lateral agranular part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16396 olfactorybulb BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.0143 HES4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66291 GTEX-PSDG-0526-SM-2S1OH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 fat_e HPA Tissue Sample Gene Expression Profiles -1.0 -1.15994 Perturb_4144_KO_Bcl11a/Bcl11b_SRP334609 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GTEX-P4QT-1626-SM-2S1NP GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 YA-92-YO01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201287 Hippocampal mossy fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.97 Brain Lower Grade Glioma_LGG_TCGA-HT-A616-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior cortical nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07109 ZNF302 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4329 SUZ12-20075857-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Ebf4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 36.4729 RCBTB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33828 GSE109140_2_v_3_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01174 interpositus (intermediate) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.877088 ELP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.69778 H4K20me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.06404 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M6-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IGR39 CCLE Cell Line Gene CNV Profiles -1.0 -1.4568 A4FUK CCLE Cell Line Gene CNV Profiles 1.0 2.60004 GSE122711_1_v_0_mpc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-2110 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null Vomeronasal organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.598 perimammillary part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01266 GTEX-XPT6-0008-SM-4B64Q GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831913 abnormal temporal memory MPO Gene-Phenotype Associations 1.0 null GTEX-WL46-0011-R2A-SM-3LK6O GTEx Tissue Sample Gene Expression Profiles 1.0 1.24625 Adrenocortical carcinoma_ACC_TCGA-OR-A5LC-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.3914 hematopoietic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052188 H3K27me3_splenic B cell_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GB-57-XV52_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.276334 cell communication GO Biological Process Annotations 2015 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SGPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21202 GSE148066,GSE157787_5_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_12253_KO|KD_SDHB|SDHA_SRP128515 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.32439 Lung squamous cell carcinoma_LUSC_TCGA-85-7950-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-596 TargetScan Predicted Conserved microRNA Targets 1.0 0.226173 terete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.41423 Primary motor area, Layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11781 GTEX-X4XX-3026-SM-3NMB2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.60302 PPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44948 hippocampus (hippocampal formation)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04493 ZNF384_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal spike wave discharge MPO Gene-Phenotype Associations 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HOXB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68515 TNFRSF10B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77757 H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null cho cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.278251 HT-115 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE151612_4_v_10_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null heart disease GWASdb SNP-Disease Associations 1.0 0.984747 Mesocorticolimbic dopaminergic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.664 GTEX-R55E-0011-R7A-SM-2TC5Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.08951 intermediate stratum of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0678 H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TFAP2E JASPAR Predicted Human Transcription Factor Targets 2025 1.0 76.9515 PEAK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0507 TEDISAMIL DGIdb Drug Targets 2026 1.0 0.189043 GSE195503_3_v_2_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null KIF4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96431 Secondary motor area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0617 Perturb_7407_KD_HNRNPM_SRP010280 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.38369 Perturb_314_KD_XBP1_SRP279319 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.41608 H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XXEK-2426-SM-4BRUS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71548 H3K4me1_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GLB1L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94682 H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NECTIN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17569 GTEX-RNOR-0011-R7A-SM-2TF4V GTEx Tissue Sample Gene Expression Profiles 1.0 1.3386 H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WL46-0011-R10A-SM-3MJFQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.63432 astroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.067756 inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02555 GTEX-XLM4-2926-SM-4AT59 GTEx Tissue Sample Gene Expression Profiles 1.0 0.939927 GSE154074_2_v_4_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null LHX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49514 GSE95688_7_v_2_glutathione_mouse RummaGEO Drug Perturbation Signatures 1.0 null CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null 22RV1 COSMIC Cell Line Gene Mutation Profiles 1.0 null SU-DHL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37077 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29N-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10709143-41556_2023_1271_MOESM7_ESM.xls-PAX7_Re-injury-Target_name_PAX7 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XUJ4-0008-SM-4BOQI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00979 a549 HPA Cell Line Gene Expression Profiles 1.0 1.54543 H3K27me3_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U7-06A-21R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041617 spontaneous GeneRIF Biological Term Annotations 1.0 null ZNF417 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.6316 CTV1DM DepMap CRISPR Gene Dependency 1.0 2.28212 metal ion transport GO Biological Process Annotations 2023 1.0 null SEZ6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19089 MPRIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38063 OVSAHO CCLE Cell Line Gene Expression Profiles 1.0 1.86681 LE-40-JW92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.303676 ACADS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72714 Perturb_2610_KD_PCF11_SRP212229 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.49186 CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20J-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X585-0011-R4B-SM-46MVH GTEx Tissue Sample Gene Expression Profiles 1.0 0.946745 A-673 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.930085 primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.905548 Anteromedial visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62469 EZH2-23942234-MYOBLASTS AND MYOTUBES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE133764_1_v_0_chd2_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WHSE-0011-R7A-SM-3P5YZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.43804 GSE174751_0_v_1_postn_mouse RummaGEO Gene Perturbation Signatures -1.0 null liminal reticular formation of m2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11337 GTEX-U3ZM-0326-SM-4DXUJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.996954 H3K27me3_cerebellum_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.13289 aire_21746930_treg_cd8pos_cd28low_lof_mouse_gpl6246_gds4373 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.490188 forebrain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.424199 PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet2-RNAseq_DEGs_of_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.1172 TNFSF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58907 PMC10170086-41598_2023_34519_MOESM6_ESM.xlsx-Shee2-The_differentially_expressed_genes_between_the_BARX2_high_and_BARX2_low_group_of_LIHC_patients_BARX2 Rummagene Transcription Factor Associations 2026 1.0 null GSE206729_3_v_0_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null igg immunoglobulin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.195025 endometrium HPA Tissue Protein Expression Profiles -1.0 -0.829897 medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.58508 lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.87942 ZNF419 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47005 GSE197117_0_v_1_kdm6b_mouse RummaGEO Gene Perturbation Signatures -1.0 null acute leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.709572 p1 part of the substantia nigra reticulata Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13073 GTEX-UJMC-1826-SM-3GADT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90951 Retrosplenial area, lateral agranular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29799 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Unnamed_1_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70O-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE145915_5_v_4_pcm1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-TSE9-1226-SM-4DXTM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24997 DHX35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.65223 H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.539 all GWASdb SNP-Phenotype Associations 1.0 0.029032 H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ROCK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39457 RBBP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91647 GSE168676_0_v_3_dach1_mouse RummaGEO Gene Perturbation Signatures 1.0 null cerebellar cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.21167 stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.25281 NCIH1573 DepMap CRISPR Gene Dependency 1.0 3.01832 GSE223334_3_v_2_bcl11b_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE198165,GSE198166_8_v_10_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE114553_0_v_1_lhx6_human RummaGEO Gene Perturbation Signatures 1.0 null SLR26 CCLE Cell Line Gene Expression Profiles 1.0 1.60275 GTF2H4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38118 plasma membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SW1573 CCLE Cell Line Gene Expression Profiles -1.0 -1.62767 beta-TC6 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.748 MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-922 TargetScan Predicted Conserved microRNA Targets 1.0 0.348832 Perturb_17037_KD_RUNX2_SRP265978 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.54583 GSE57871_6_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null USB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14415 TXNDC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41144 MCF 10A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.51211 SCLC-22H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16934 OCI-LY-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18499 CTCF_retinal pigment epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BMI1 ChEA Transcription Factor Targets 1.0 null POU5F1-16518401-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CORL105 CCLE Cell Line Gene Expression Profiles -1.0 -1.5302 H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE131161_5_v_4_rarres1_mouse RummaGEO Gene Perturbation Signatures -1.0 null APLP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95556 Prelimbic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21159 HEC1B CCLE Cell Line Gene Expression Profiles 1.0 2.04562 GSE126345_0_v_10_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null HSPBAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23845 mantle zone of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2294 GSE248887_0_v_1_dkk1_human RummaGEO Gene Perturbation Signatures 1.0 null FBXO11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30108 GSE126127_0_v_1_prmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8042-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REST-19997604-NEURONS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null exocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.075803 NCIH2110 DepMap CRISPR Gene Dependency 1.0 5.99281 BOLA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48403 caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.973833 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12870_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Meniere's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.358 NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.68659 NEUROD2-26341353-CORTEX-MOUSE ChEA Transcription Factor Targets 2022 1.0 null COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14798 GTEX-R55C-1726-SM-3GADJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30916 EGR1-20690147-ERYTHROLEUKEMIA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ARG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7088 H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GOLGA8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80561 ChIP_NR0B1_18358816 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null INO80D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8635 NCIH2342 CCLE Cell Line Gene CNV Profiles 1.0 2.034 GTEX-WL46-0011-R6A-SM-3LK6X GTEx Tissue Sample Gene Expression Profiles 1.0 0.871343 CREB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25618 SIN3A ENCODE Transcription Factor Targets 1.0 null BMI1-23680149-NPCS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null BCPAP COSMIC Cell Line Gene Mutation Profiles 1.0 null passive transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null GTEX-X4XY-0926-SM-4E3JD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05366 TOMM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40986 PMC7412812-13059_2020_2115_MOESM11_ESM.xlsx-Overlap-Upregulated_in_SERBP1_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE206270_2_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF208 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6389 POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE239898,GSE239899_1_v_0_hiltonol_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H1155 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.20665 intermediate stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17451 H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null integral component of plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GSE142684_3_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null P2RX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05014 Infralimbic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1396 YPEL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92099 GSE149943_1_v_0_cd8a_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-P4PQ-0008-SM-48TDX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28997 Lung squamous cell carcinoma_LUSC_TCGA-56-8307-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of ZIC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14303 GTEX-OHPN-0011-R5A-SM-2I5FF GTEx Tissue Sample Gene Expression Profiles 1.0 1.01847 Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A40X-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null skeletal system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052614 GSE207514,GSE207515_1_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures 1.0 null Taenia tecta, dorsal part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12548 CAL62 CCLE Cell Line Gene Expression Profiles -1.0 -1.48098 GTEX-WZTO-0011-R3B-SM-3NMC6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.67166 abnormal single cell response MGI Mouse Phenotype Associations 2023 1.0 null GYS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85799 PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_nuc-DEGs_for_hnRNPK_KD_Nuclear_RNA_of_HeLa_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null regulation of biological process GO Biological Process Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Secondary motor area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10425 GSE174701_5_v_8_maml3_human RummaGEO Gene Perturbation Signatures -1.0 null WC-09-GD62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.309058 TAL1::TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.2273 PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null Retrosplenial area, lateral agranular part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20432 GTEX-XUYS-0226-SM-47JX1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.875225 mantle zone of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01266 H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null transport GO Biological Process Annotations 2015 1.0 null superficial stratum of r2Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15441 H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null PLCB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45086 PCDHB9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61382 496100651_FWM_probable Alzheimer's disease_TBI_83_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.20125 ZNF587B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45394 H3K9me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null substrate-specific transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null SNU-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null PCDHB13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70809 intrinsic component of plasma membrane GO Cellular Component Annotations 2015 1.0 null regulation of localization GO Biological Process Annotations 2015 1.0 null GTEX-S33H-2426-SM-2XCB2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.896363 GSE111138,GSE111149_1_v_0_runx3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE234340_1_v_7_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null cognitive GeneRIF Biological Term Annotations 1.0 null NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.41674 ZNF429 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.04931 H3K27me3_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain - Spinal cord (cervical c-1) GTEx Tissue Gene Expression Profiles 2023 1.0 1.86583 TCEAL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98953 NFIC::TLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.75 Paneth cell_Intestinal crypt_Mouse CellMarker Gene-Cell Type Associations 1.0 null NAT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87141 H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null suprachiasmatic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03278 LRRCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89738 KCNK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35208 superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.95746 PROX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4087 HIF1AN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14777 GSE126345_4_v_5_hcrt_mouse RummaGEO Gene Perturbation Signatures -1.0 null phosphotransferase activity, alcohol group as acceptor GO Molecular Function Annotations 2015 1.0 null CTCF_GM12864_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.37495 H3K27me3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PTBP1_02_120 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 4.90689 neuroblastoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.106658 Perturb_17317_KO_Ddx5_SRP284247 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.4553 GSE129244_3_v_1_lmo2_mouse RummaGEO Gene Perturbation Signatures -1.0 null NT5C3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95497 GSE217363_0_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null PDSS2_KO_GDS3454_120_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null outer SZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.903771 H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null plasma membrane GO Cellular Component Annotations 2015 1.0 null FZD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.86187 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.496874 HS633T COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-XUW1-0526-SM-4BOP3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.95564 H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TAF1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.354 CALML6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33064 female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051427 STOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60371 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.32693 GTEX-QDVJ-1826-SM-2S1P3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05506 CHP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45852 H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97547 GTEX-W5WG-0008-SM-4KL25 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36051 GTEX-WL46-2926-SM-3LK82 GTEx Tissue Sample Gene Expression Profiles 1.0 2.44178 H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H1_BMP4_Derived_Trophoblast_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -2.00746 496100409_FWM_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.71336 brain GTEx Tissue Gene Expression Profiles 1.0 1.37035 HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01174 HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.11966 NCOA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4769 SCARB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89102 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4653-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 PINLYP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70784 ChIP_H3K27me3_20682450_humanESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null SU-DHL-8 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE202434,GSE202438_13_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null EIF3J CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7752 EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.855353 GTEX-NPJ8-0011-R6a-SM-2HMKB GTEx Tissue Sample Gene Expression Profiles 1.0 0.855881 H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-GRHL2_GRHL2 Rummagene Transcription Factor Associations 2026 1.0 null IQGAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46925 Spleen GTEx Tissue Gene Expression Profiles 2023 1.0 1.71898 PMC7412812-13059_2020_2115_MOESM11_ESM.xlsx-All_H3K27me3-Upregulated_in_SERBP1_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null ganglion TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069764 GSE148695,GSE167281_2_v_1_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null EA-18-FP00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.304489 Cornu ammonis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.669 496100596_FWM_dementia_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.37894 MAP1LC3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28839 Posterior parietal association areas, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53328 Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A894-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HOXB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35128 GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles 1.0 0.849236 Perturb_12296_KD_RORC_SRP066204 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.00572 Hippocampal pyramidal layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.785 PMC12019336-41467_2025_58868_MOESM5_ESM.xlsx-Open_peaks_IKAROS_WT-Unnamed_11_IKZF1 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-2467-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.828473 MSL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51117 PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_42_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null MESP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01087 potassium channel activity GO Molecular Function Annotations 2023 1.0 null NH-12 COSMIC Cell Line Gene Mutation Profiles 1.0 null NR1H2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49554 H4K20me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13534 GSE148066,GSE157787_2_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE236454,GSE236456_0_v_1_angiotensin ii_mouse RummaGEO Drug Perturbation Signatures 1.0 null intermediate stratum of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38129 LOX-IMVI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.855353 GTEX-X585-0008-SM-46MU4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35634 GSE57871_5_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null ChIP_MTF2_20144788 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null ChIP_EZH2_18974828 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE111660_1_v_3_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null cellular process GO Biological Process Annotations 2015 1.0 null Ventral pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13025 H3K27me3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPU-2326-SM-2TF6R GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 H3K4me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CYB5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57733 DMAC2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28399 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.079 GTEX-WWYW-0011-R10A-SM-3NB35 GTEx Tissue Sample Gene Expression Profiles 1.0 1.48384 hsa-miR-3191 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 RCOR1 ENCODE Transcription Factor Targets 1.0 null GTEX-U412-0526-SM-3DB9I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16338 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null medial preoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.98218 H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null NCIH1105 CCLE Cell Line Gene CNV Profiles -1.0 -1.82404 SMAD4 ChEA Transcription Factor Targets 1.0 null PAC motif InterPro Predicted Protein Domain Annotations 1.0 null UACC257 DepMap CRISPR Gene Dependency 1.0 3.04065 Primary somatosensory area, trunk, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46101 GSE143316_3_v_6_somatostatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null ASNSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66937 Anteromedial visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.07056 OAZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35774 CEP164 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.93729 GTEX-SNMC-0006-SM-2XCFE GTEx Tissue Sample Gene Expression Profiles 1.0 1.66121 BC-84-BQ58_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208301 ZNF80 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60566 H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null anterior part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07505 HPAFII CCLE Cell Line Gene CNV Profiles 1.0 1.93817 KPNA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41441 Perturb_7403_KD_HNRNPA2B1_SRP010280 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.21458 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R53T-0005-SM-3GADK GTEx Tissue Sample Gene Expression Profiles 1.0 0.902364 NCI-H2804 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.51666 GTEX-XLM4-0011-R6A-SM-4AT4B GTEx Tissue Sample Gene Expression Profiles 1.0 1.12741 MAFA MotifMap Predicted Transcription Factor Targets 1.0 null 496100608_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.21976 caudal ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.1154 AF-99-HA02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.29642 GTEX-QDT8-0426-SM-32PKZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827632 HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NAPRT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5232 SLC29A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.29377 POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NME1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54041 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70T-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q734-0008-SM-48U2I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01711 supraoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02392 MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.58346 fallopiantube_8e HPA Tissue Sample Gene Expression Profiles 1.0 0.885572 Orbital area, medial part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06209 DDX27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76455 rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.035383 GSE188869,GSE188871_1_v_3_kat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null AB-18-YN11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201857 ESYT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59523 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5989-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE198254_1_v_0_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null IKZF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7333 cterminus GeneRIF Biological Term Annotations 1.0 null Parathyroid gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 external part of AOV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.07435 OXLD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28609 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10058 ZNF664 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21021 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19316 GTEX-XOTO-0011-R6B-SM-4B65X GTEx Tissue Sample Gene Expression Profiles 1.0 0.942831 GTEX-NL4W-0008-SM-4E3I2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10971 NR0B1-18358816-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE130246_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XLM4-0011-R4B-SM-4AT5C GTEx Tissue Sample Gene Expression Profiles 1.0 1.28464 GTEX-OIZI-0008-SM-2XCFD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7847 head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.842189 CCNJ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.31669 HEXD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26687 ZC3H3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31037 H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Cerebellar ataxia type 42 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.009 hsa-miR-874 TargetScan Predicted Conserved microRNA Targets 1.0 0.226173 GTEX-SIU7-0526-SM-3NM8I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33994 UACC812 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.94369 seizures GeneRIF Biological Term Annotations 1.0 null SK-N-AS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.27764 plasma membrane LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-TKQ2-1826-SM-33HB2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.945903 Voltage gated Potassium channels Reactome Pathways 2024 1.0 null MKN7 CCLE Cell Line Gene CNV Profiles -1.0 -1.66174 GSE221327_5_v_2_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.869875 CYBA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64775 GTEX-SIU8-0526-SM-2XCDP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.880947 transferase activity GO Molecular Function Annotations 2015 1.0 null GATA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18698 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5196-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TSE9-0011-R6A-SM-3DB7L GTEx Tissue Sample Gene Expression Profiles 1.0 0.967625 MAFF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60559 SELENOH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33247 TAL1 MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-WL46-2826-SM-3LK81 GTEx Tissue Sample Gene Expression Profiles 1.0 0.87071 SW 620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08162 TGFBR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91576 P53-21459846-SAOS-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LOVO COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null channel activity GO Molecular Function Annotations 2015 1.0 null SLC8A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5781 GPR50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73701 ERLIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42523 ASAH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63517 KNS81 Achilles Cell Line Gene Essentiality Profiles -1.0 -2.50863 H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T6MO-0008-SM-4DM6T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6638 SIMA COSMIC Cell Line Gene Mutation Profiles 1.0 null SuperiorCervicalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.890193 MFSD2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93614 CISD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64228 NFE2L2 ChEA Transcription Factor Targets 1.0 null H4K20me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null superficial gray layer of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27541 rectum HPA Tissue Protein Expression Profiles 1.0 0.882435 GTEX-T5JC-2426-SM-3NMDB GTEx Tissue Sample Gene Expression Profiles 1.0 2.81973 autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.045986 AR-35650195-DSRCT-HUMAN-MESENCHYMAL-SARCOMA ChEA Transcription Factor Targets 2022 1.0 null DALFAMPRIDINE DGIdb Drug Targets 2026 1.0 0.171857 H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RAD21_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF3_02_180 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.90689 USF1 ENCODE Transcription Factor Targets 1.0 null GTEX-RM2N-0008-SM-48FF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17987 cerebellar cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.857432 PL-21 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.839453 BV-173 COSMIC Cell Line Gene Mutation Profiles 1.0 null abnormal long term object recognition memory MPO Gene-Phenotype Associations 1.0 null EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JURKAT COSMIC Cell Line Gene Mutation Profiles 1.0 null Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.077 GTEX-T6MN-0011-R1A-SM-32QOY GTEx Tissue Sample Gene Expression Profiles 1.0 1.13549 GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.896115 GTEX-WWYW-0011-R6A-SM-3NB3G GTEx Tissue Sample Gene Expression Profiles 1.0 1.13592 BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11865 hematologic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.249608 MFNG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64608 H3K4me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ATP6V1G1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.924 Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pyramidal neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.785 pyramidal layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.846118 PMC7064337-elife-51373-supp1.xlsx-SUZ12_targets_shPHF19-List_of_567_genes_marked_by_SUZ12_ChIPseq_iafter_PHF19_KD_shPHF19_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-O5YV-2026-SM-2D7VS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.879837 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null peripheral nervous system neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.158097 GTEX-XLM4-0011-R3B-SM-4AT6E GTEx Tissue Sample Gene Expression Profiles 1.0 1.27654 cerebellar cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.81816 FAM83D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54705 amygdaloid complex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.03023 GTEX-T6MN-0008-SM-4DM7H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64103 SNRNP70 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41306 Orbital area, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04041 GTEX-S4Q7-1126-SM-4AD6R GTEx Tissue Sample Gene Expression Profiles -1.0 -0.958146 H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_4600_KO_Mettl3_SRP048598 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 TM9SF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8779 ZRANB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39771 PIK3R3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05113 core part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0489 NSMCE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33054 Purkinje cell layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12126 CXADR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77458 GSE187006_0_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null HS683 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.31262 GTEX-SIU8-0008-SM-4BRUC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03903 TYKNU DepMap CRISPR Gene Dependency 1.0 2.06995 H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF827 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75965 H3K27me3_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142210_4_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-T2IS-0011-R6A-SM-32QP2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.9312 GSE215086_0_v_2_batf_mouse RummaGEO Gene Perturbation Signatures 1.0 null TIG3TD CCLE Cell Line Gene Expression Profiles 1.0 1.43422 GSE231891_1_v_0_cdk8_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-T5JC-0011-R7A-SM-32PME GTEx Tissue Sample Gene Expression Profiles 1.0 1.28208 Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AGO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27043 GTEX-XOT4-0008-SM-4B664 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.983783 LS-180 COSMIC Cell Line Gene Mutation Profiles 1.0 null precommissural nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.2253 GTEX-PVOW-2526-SM-2XCF7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.77049 ATP5MF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26872 HINFP JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.6328 GSE195559_0_v_9_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-FC-A8O0-01A-41R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PU.1-20513432-BCELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-U412-0008-SM-4DXTE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40283 TNFRSF10D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5817 GSE142210_4_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE232631_5_v_2_brca2_mouse RummaGEO Gene Perturbation Signatures -1.0 null morphine_mus musculus_gpl6246_gse17731 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-QDT8-0011-R10A-SM-32PKG GTEx Tissue Sample Gene Expression Profiles 1.0 1.21809 GSE206729_5_v_1_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Supplementary_Table_2F_Contrast_ATF4-def_IGG_8h_vs_HCT116_IGG_8h_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null NT5DC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22296 Charcot-Marie-Tooth disease recessive intermediate B DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.338 GTEX-U8T8-0008-SM-4DXSP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4434 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6UY-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_14116_KD_RPS6KB1_SRP187713 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.54305 GSE135400_2_v_0_kdm1b_mouse RummaGEO Gene Perturbation Signatures -1.0 null report GeneRIF Biological Term Annotations 1.0 null OLIG2-26023283-AINV15-MOUSE ChEA Transcription Factor Targets 2022 1.0 null HS578T Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.712572 GSE146982_3_v_2_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE149880_0_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null Dorsal peduncular area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03588 Ion transport domain InterPro Predicted Protein Domain Annotations 1.0 null COV434 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.854106 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5703-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KLF4-25985364-ATHEROSCLEROSIS-LESION-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-RTLS-0008-SM-48FET GTEx Tissue Sample Gene Expression Profiles -1.0 -0.947575 leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.166319 Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8844_KD_ESRRA_SRP254908 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 abnormal spatial working memory MPO Gene-Phenotype Associations 1.0 null SSRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92718 GSE175787_8_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8513-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RU72-0011-R5A-SM-2TF6U GTEx Tissue Sample Gene Expression Profiles 1.0 1.07568 GTEX-QVUS-0011-R6A-SM-3GACX GTEx Tissue Sample Gene Expression Profiles 1.0 0.847212 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GULP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25546 NRSN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78733 SEPTIN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90206 H3K27me3_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MICAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76119 orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.19672 cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.10173 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE147876,GSE147877_4_v_11_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE206729_4_v_0_trps1_human RummaGEO Gene Perturbation Signatures 1.0 null BSDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99994 JAK2_activemutant_72_GSE21842 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.98413 MTF2-20144788-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.491 GTEX-UTHO-0011-R4A-SM-3GIJP GTEx Tissue Sample Gene Expression Profiles 1.0 0.914623 CTCF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23693 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_17625_KO_TP53_SRP153109 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.21487 HT-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18499 ZNF546 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34343 DND-41 COSMIC Cell Line Gene Mutation Profiles 1.0 null phosphorus metabolic process GO Biological Process Annotations 2015 1.0 null TF1 DepMap CRISPR Gene Dependency 1.0 3.1658 BHLHE40_02_186 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.16993 HS 852.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.838309 NG-108-15 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.898 Liver hepatocellular carcinoma_LIHC_TCGA-WQ-A9G7-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ChIP_H3K27me3_17603471_mouseESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03202 C84 DepMap CRISPR Gene Dependency 1.0 7.04102 GSE153189_1_v_3_stat1_mouse RummaGEO Gene Perturbation Signatures 1.0 null COX19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.47285 UBF1/2-26484160-CHIP-SEQ-FIBROBLAST-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-UTHO-0011-R6A-SM-3GIJW GTEx Tissue Sample Gene Expression Profiles 1.0 0.970225 Vital Capacity DisGeNET Gene-Phenotype Associations 1.0 null GSE111660_1_v_5_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null TRAF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32787 abnormal nervous system electrophysiology MPO Gene-Phenotype Associations 1.0 null Perturb_8811_KD_CGAS_SRP340417 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Neuronal System Reactome Pathways 2024 1.0 null SLR23 CCLE Cell Line Gene Expression Profiles 1.0 1.35731 NXPE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30472 GTEX-U8XE-0426-SM-3DB91 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36554 GTEX-U8XE-1926-SM-3DB98 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09474 BHLHE22 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.9104 Perturb_2270_KO_lincBrn1b_SRP028547 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null 496100616_FWM_no dementia_TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.0324 Cerebellar mossy fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.173 WT1-25993318-PODOCYTE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-S4Z8-1226-SM-4AD6W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.959617 abnormal synaptic transmission MPO Gene-Phenotype Associations 1.0 null ARNT_01_315 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59375 GSE262134_0_v_1_dnajc12_human RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210101,GSE210114_0_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletal muscle HPA Tissue Protein Expression Profiles -1.0 -1.86909 GTEX-T6MN-0011-R7A-SM-32QP5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20954 GSE214514_1_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CREB1 ENCODE Transcription Factor Targets 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2888-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7476-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U4B1-0326-SM-3DB8K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24964 MZ in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.941338 abnormal long-term object recognition memory MGI Mouse Phenotype Associations 2023 1.0 null TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.640682 Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A6C5-11A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RUNX1-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE102505_5_v_3_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_2598_KD_PRMT6_SRP131294 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.25511 H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ovary BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.976053 Perturb_13056_Mut|OE_Sik3E13_SRP334442 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.69288 TFAP2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.477 amygdaloid complex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.831711 Developmental disorder of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.556 intermediate stratum of isLim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40931 ERFL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41828 doxycycline_mus musculus_gpl2872_gse33875 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ETFRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8002 AP3S1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.87622 cell part LOCATE Predicted Protein Localization Annotations 1.0 null GB-57-XV52_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.377617 JM1 CCLE Cell Line Gene CNV Profiles 1.0 3.27903 GSE118077_4_v_2_sprr5_human RummaGEO Gene Perturbation Signatures -1.0 null HNT34 Achilles Cell Line Gene Essentiality Profiles 1.0 1.13686 GSE223334_3_v_0_bcl11b_mouse RummaGEO Gene Perturbation Signatures -1.0 null TMEM240 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53743 ADNP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97945 MZ in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.49506 membrane GO Cellular Component Annotations 2015 1.0 null pyramidal layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.66595 H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Ebf2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.3327 metal ion transport GO Biological Process Annotations 2025 1.0 null XPNPEP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.761 GTEX-WEY5-1926-SM-3GIL8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00185 PCDH8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01604 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.74091 ZBTB14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.0724 GTEX-R55E-0011-R6A-SM-2TC5T GTEx Tissue Sample Gene Expression Profiles 1.0 0.987762 Psychotic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.434 GTEX-T8EM-1626-SM-3DB7K GTEx Tissue Sample Gene Expression Profiles -1.0 -0.976679 TBX2-33478486-IMR90-HUMAN-LUNG ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TFAP4::FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.0431 NCI-H1666 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.855353 GSE210101,GSE210114_7_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null SG in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.4078 GTEX-R55E-0008-SM-48FCG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54871 GSE68925_1_v_0_fasudil_human RummaGEO Drug Perturbation Signatures -1.0 null Fallopian Tube GTEx Tissue Gene Expression Profiles 2023 1.0 3.95993 PMC11530676-41598_2024_77248_MOESM1_ESM.pdf-18-SHOX2_SHOX2 Rummagene Transcription Factor Associations 2026 1.0 null GSE197686,GSE197688_2_v_0_arid1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null kinase activity GO Molecular Function Annotations 2015 1.0 null SK-MEL-28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07941 Perturb_2999_KD_COMP_SRP302197 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.48578 MEC1 CCLE Cell Line Gene CNV Profiles -1.0 -2.37729 stratum pyramidale of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.886 PROX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43918 F5 CCLE Cell Line Gene Expression Profiles 1.0 2.23326 LRATD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74053 GSE209698_0_v_1_calcitriol_human RummaGEO Drug Perturbation Signatures -1.0 null pineal_day BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.02756 GTEX-XMD1-0011-R10A-SM-4AT4A GTEx Tissue Sample Gene Expression Profiles 1.0 0.867867 SLC22A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0174 FOXA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.15006 increased susceptibility to pharmacologically induced seizures MPO Gene-Phenotype Associations 1.0 null EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.240826 Ebolavirus(EBOV)_7day_Splenocytes_19683682_GSE17509 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.60816 Lung adenocarcinoma_LUAD_TCGA-91-8499-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null increased hemoglobin content IMPC Knockout Mouse Phenotypes 1.0 null GABRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.9606 ZNF608 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99953 NUDT19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20843 PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_16_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null AK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90195 mouth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.072255 AOB, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4731 brain_3c HPA Tissue Sample Gene Expression Profiles 1.0 1.87892 496100543_FWM_probable Alzheimer's disease_TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.23557 CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMD1-0011-R3B-SM-4AT5R GTEx Tissue Sample Gene Expression Profiles 1.0 0.924208 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null inner CP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09162 LIM1215 COSMIC Cell Line Gene Mutation Profiles 1.0 null DNAJC13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20519 ABCD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09711 SOX9-25088423-EMBRYONIC-GONADS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SCC9 CCLE Cell Line Gene Expression Profiles -1.0 -1.97727 H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Macaque_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null PRICKLE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45007 CTCF_HEK293_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149903_0_v_7_myd88_mouse RummaGEO Gene Perturbation Signatures -1.0 null JC-06-ED36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.307625 Perturb_2635_KD_TRIM46_SRP323434 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.22098 GTEX-TSE9-3126-SM-4DXSY GTEx Tissue Sample Gene Expression Profiles 1.0 1.01055 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5707-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BD-96-HO33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.231768 PMC7412812-13059_2020_2115_MOESM11_ESM.xlsx-All_SUZ12-Upregulated_in_SERBP1_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null TOMM20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82734 GTEX-QMR6-0011-R10A-SM-32PKO GTEx Tissue Sample Gene Expression Profiles 1.0 1.23467 SIN3B-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null VCPIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92985 Detrusor TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.621 medial intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.847683 KE-73-XV62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.289986 Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7MA-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCT116 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.00526 H3K27me3_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hl60 HPA Cell Line Gene Expression Profiles -1.0 -1.15888 YD-49-HM53_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.23827 molecular layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.8945 GTEX-OIZG-0008-SM-4E3J2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824025 Lung adenocarcinoma_LUAD_TCGA-55-6986-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE211983_1_v_2_nicotine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE153189_1_v_3_interferon gamma_mouse RummaGEO Drug Perturbation Signatures 1.0 null AK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.1084 NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19435 Primary T cells from cord blood Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.98492 H3K27me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ1-1126-SM-4GIAZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1184 GSE126777_3_v_1_otub1_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.945087 POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS 255.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.06463 CYFIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57434 H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE242199_6_v_11_ntrk2_human RummaGEO Gene Perturbation Signatures -1.0 null MDAMB134VI CCLE Cell Line Gene CNV Profiles 1.0 1.67727 negatively GeneRIF Biological Term Annotations 1.0 null captopril_mus musculus_gpl1261_gds3683 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-QV31-0008-SM-447AT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.88969 GTEX-T5JC-0011-R5A-SM-32PLK GTEx Tissue Sample Gene Expression Profiles 1.0 1.34082 GSE236486_1_v_0_arnt_human RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-889 TargetScan Predicted Conserved microRNA Targets 1.0 0.436802 Brain_Hippocampus_Middle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 2.64618 GSE195568_3_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE206270_1_v_0_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null TRIM33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35081 intermediate gray layer of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23578 Smooth endoplasmic reticulum cisterna COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.853 GTEX-QVJO-0011-R10A-SM-2S1QJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.34438 Sarcoma_SARC_TCGA-IE-A3OV-01A-11R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBC1D10A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66846 GSE96777,GSE96778_1_v_0_zbtb4_human RummaGEO Gene Perturbation Signatures 1.0 null PMC9232687-13238_2021_887_MOESM3_ESM.xlsx-37_KD_sgCDC20_vs_sgNTC-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null BRIX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06304 CTCF_BE2C_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of IC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07996 abnormal single cell response MPO Gene-Phenotype Associations 1.0 null CFAP157 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48509 laterorostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50694 CTCF_fibroblast of upper leg skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_kidney_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_2874_Mut_KRAS_SRP404927 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 COPS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45468 H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null mantle zone of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45214 increased susceptibility to induction of seizure by inducing agent MPO Gene-Phenotype Associations 1.0 null hsa-miR-3121-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 PMC7594423-12915_2020_895_MOESM13_ESM.xlsx-Table_S6D-Table_S6D_-_Differentially_Expressed_genes_shared_between_BRCA_TRIM25_amp_and_STAD_CIC_Del_CIC Rummagene Transcription Factor Associations 2026 1.0 null MKNK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09413 BRPF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86667 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null AURKB_knockdown_92_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.6871 GTEX-Q2AH-1726-SM-3NB2B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.898486 GSE119498_0_v_5_setd5_mouse RummaGEO Gene Perturbation Signatures 1.0 null cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-RWSA-0008-SM-47JYX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49093 Hypertrophy CTD Gene-Disease Associations 1.0 1.02783 astroglial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.067756 PMC10703699-41588_2023_1554_MOESM3_ESM.xlsx-T4B_BATF3_upreg_padj_0_01-Gene_Name_BATF3 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE143944_2_v_3_ribociclib_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF257 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.7819 GTEX-NPJ7-0011-R1a-SM-3GACT GTEx Tissue Sample Gene Expression Profiles 1.0 0.926161 GTEX-Q2AG-0011-R6A-SM-2HML7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16171 GSE146982_7_v_1_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TMEM134 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94948 SUZ12-18692474-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-QDT8-0011-R4A-SM-32PKM GTEx Tissue Sample Gene Expression Profiles 1.0 0.945422 GTEX-N7MS-2526-SM-2D7W3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.924122 inorganic cation transmembrane transport GO Biological Process Annotations 2025 1.0 null POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE236437_2_v_3_aldosterone_human RummaGEO Drug Perturbation Signatures -1.0 null cerebellar cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.933214 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null ML-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.74622 EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.45086 CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.891027 PA1 DepMap CRISPR Gene Dependency 1.0 2.22672 CTCF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_3797_KO_BRG1_SRP165661 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null abnormal single cell response threshold MPO Gene-Phenotype Associations 1.0 null CD34+ BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.2759 TBX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1418 H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytoplasmic side of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.463198 GTEX-QVUS-2826-SM-3GADB GTEx Tissue Sample Gene Expression Profiles 1.0 1.44965 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A4BA-01A-21R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE125014_6_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XUYS-0008-SM-47JYZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 GSE207863_0_v_1_hdac5_human RummaGEO Gene Perturbation Signatures 1.0 null GTF2A1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25113 SHSY5Y CCLE Cell Line Gene Expression Profiles -1.0 -2.22346 PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null MEF2A-21415370-HL-1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CXCL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12063 plasma membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.057531 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-06A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OHPM-0008-SM-4E3IP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36882 r1 part of trigeminal sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26178 GSE119498_0_v_7_setd5_mouse RummaGEO Gene Perturbation Signatures 1.0 null Dorsal raphe nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.542 MUTZ8 DepMap CRISPR Gene Dependency 1.0 6.09838 Paraflagellar rod COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.962 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5109-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RU72-3126-SM-46MUB GTEx Tissue Sample Gene Expression Profiles 1.0 0.991282 AtrioventricularNode BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.66641 H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null XPC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39745 RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.03073 COX10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85333 CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ENTPD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26604 H3K27me3_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Stomach TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE140607_5_v_6_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null ISG20L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32056 H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MJ-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null isthmic alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01717 binding GO Molecular Function Annotations 2015 1.0 null GSE69244_1_v_0_j147_mouse RummaGEO Drug Perturbation Signatures -1.0 null Age at first birth GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.8 SUGT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56486 MALSU1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87227 GTEX-VUSG-2626-SM-4KKZI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28209 PMC12640707-NIHMS2124006-supplement-Supplemental_tables.xlsx-Supplemental_Table_S4-Supplemental_Table_S4_Genes_commonly_upregulated_in_both_clones_of_ZFX-depleted_HEK293T_cells_in_Ni_et_al_2020_ZFX Rummagene Transcription Factor Associations 2026 1.0 null CHD2 ENCODE Transcription Factor Targets 1.0 null SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FF-28-ES17_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.662356 chr12_49522228_G_GTTGAT_b38 GTEx eQTL 2025 1.0 1.14603 15656903-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null G122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46087 LMNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25907 PSMA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29567 H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_13_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null RAB18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84957 CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCDC14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95118 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.55676 TTLL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49518 EZH2_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Intelligence DisGeNET Gene-Phenotype Associations 1.0 null PBX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66666 rectum_8d HPA Tissue Sample Gene Expression Profiles -1.0 -1.24119 fertilizedegg BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.37405 H3K9me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K9me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CRMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61004 hsa-miR-324-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GSE86507,GSE86509_7_v_2_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE222574_0_v_2_lmna_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsofrontal pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.08476 H3K27me3_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11892598-pnas.2417308122.sd05.xlsx-DEGs_of_RORC_cluster-Unnamed_1_RORC Rummagene Transcription Factor Associations 2026 1.0 null CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EW1 DepMap CRISPR Gene Dependency 1.0 2.80462 H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null COLO 320DM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.826955 PAN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60924 C170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.859982 MPP-89 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-QESD-1526-SM-2S1QT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03998 ataxia telangiectasia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.522659 CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3163 TargetScan Predicted Conserved microRNA Targets 1.0 0.361556 GSE153137,GSE153140_2_v_0_mettl5_mouse RummaGEO Gene Perturbation Signatures -1.0 null ABCF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58469 repression GeneRIF Biological Term Annotations 1.0 null cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.067614 Liver GTEx Tissue Gene Expression Profiles 2023 1.0 1.41669 GSE153354_0_v_1_tcf19_human RummaGEO Gene Perturbation Signatures 1.0 null dorsal thalamus_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.21061 increased susceptibility to pharmacologically induced seizures MGI Mouse Phenotype Associations 2023 1.0 null CHMP2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5238 GTEX-P44H-0008-SM-48TDW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44841 GTEX-N7MT-0011-R7a-SM-2I3FZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.06467 such GeneRIF Biological Term Annotations 1.0 null GSE211286_1_v_3_tcf12_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE241701_1_v_0_daxx_mouse RummaGEO Gene Perturbation Signatures -1.0 null glial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.103242 A4/FUK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.61632 GSE224096_1_v_0_cocaine_human RummaGEO Drug Perturbation Signatures 1.0 null DCAF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02689 KLF4-18358816-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null AKAP17A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64976 MV-4-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.40478 Mesopallium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.607 QTRT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59371 orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.824243 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE146982_4_v_6_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null EAST syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.098 Prostate adenocarcinoma_PRAD_TCGA-HC-7747-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.87396 ATF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43921 H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null TFAP2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 170.904 RIMKLA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7846 PMC7576810-41419_2020_3099_MOESM9_ESM.xlsx-MS_analysis_EVI1-WT_vs_EVI1-S43-Unnamed_0_MECOM Rummagene Transcription Factor Associations 2026 1.0 null TNNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6236 YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_15071_OE_Fezf2_SRP041818 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 8.07954 H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7888 Endoplasmic reticulum cisternal network COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.851 GTEX-P44H-0011-R1A-SM-3NM8J GTEx Tissue Sample Gene Expression Profiles 1.0 1.8181 H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DMS454 CCLE Cell Line Gene CNV Profiles 1.0 1.56245 Perturb_1366_KD_GRWD1_SRP252209 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.32762 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null MIEN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08765 EF-74-KW12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.209558 ZNF677 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46827 SNX27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.38994 HSFX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47124 GTEX-TSE9-3026-SM-3DB76 GTEx Tissue Sample Gene Expression Profiles 1.0 1.9412 Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KARPAS-45 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE195568_2_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null PMC10754720-12031_2023_2122_MOESM1_ESM.docx-0-GATAD2A_GATAD2A Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8755441-mmc3.xlsx-IRF1-Down-Symbol_IRF1 Rummagene Transcription Factor Associations 2026 1.0 null CP in rostral hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.46538 GTEX-NPJ7-0011-R4a-SM-2I3GJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.965375 GSE188869,GSE188871_2_v_3_kat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null molecular transducer activity GO Molecular Function Annotations 2015 1.0 null abnormal spatial working memory MGI Mouse Phenotype Associations 2023 1.0 null GSE230744,GSE237803_5_v_2_hira_human RummaGEO Gene Perturbation Signatures 1.0 null SB-94-ZA83_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.31884 Perturb_7192_OE_DIMT1_SRP267960 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.26657 PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_2-Supplemental_Table_S1_2_Genes_significantly_upregulated_by_ARID5B_knockdown_ARID5B Rummagene Transcription Factor Associations 2026 1.0 null mRNA_ESX1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-NPJ8-1326-SM-3LK6B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75621 HOXB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46379 primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.873983 PMC7203476-Table_3.XLSX-Sheet1-GV_MI_overlap_227_MITF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OHPN-0011-R11A-SM-2I5FM GTEx Tissue Sample Gene Expression Profiles 1.0 0.838215 GSE145915_3_v_2_pcm1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-6778-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE175787_11_v_7_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null A-172 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.712 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null GSE113329,GSE113335_3_v_4_taf6l_mouse RummaGEO Gene Perturbation Signatures -1.0 null FGF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17104 Gustatory areas, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03438 Orbital area, medial part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22114 H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Learning Disorders CTD Gene-Disease Associations 1.0 1.08266 496100278_FWM_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.39845 GTEX-S32W-2026-SM-4AD6E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18103 GSE89729_0_v_1_ppard_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2F4_02_200 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.2854 GSE181517_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H650 COSMIC Cell Line Gene Mutation Profiles 1.0 null ACTL6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99393 MZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03646 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UXT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36213 GET3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76524 H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CL-40 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.50026 LAMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65455 GSE146982_4_v_1_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2833-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HUP-T3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.7649 SW156 DepMap CRISPR Gene Dependency 1.0 2.26058 GTEX-QXCU-0008-SM-48FCH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.947208 HD-29-LW24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.248083 MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.66357 DAXX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41067 Orbital area, medial part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02649 BC-13-OQ01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.393842 NFE2L2-20460467-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Up_regulated_DEGs_of_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null Perturb_5321_KD_Stag1_SRP244261 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.20043 PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_19_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null HDGFL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30705 NAPB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03538 H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r2 part of principal trigeminal sensory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15441 PCI-15A COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null single-organism localization GO Biological Process Annotations 2015 1.0 null GTEX-RVPV-0526-SM-47JYL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17208 H3K27ac_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FF-86-NH56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.202329 external part of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49384 H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_epithelial cell of proximal tubule_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RASSF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04097 GTEX-WEY5-0008-SM-4LMKC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29768 PUR1 MotifMap Predicted Transcription Factor Targets 1.0 null Usp22_DEPLETION_GDS4973_284_mouse_E14 embryonic stem cells (ESCs) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null NFE2L2-20460467-MEF-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null mantle zone of isLim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66057 H3K27me3_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_13864_KD_KDM6B_SRP258989 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 ISL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3227 PMC7064337-elife-51373-supp1.xlsx-EZH2_targets_shPHF19-List_of_2084_genes_marked_by_EZH2_ChIPseq_after_PHF19_KD_shPHF19_AR Rummagene Transcription Factor Associations 2026 1.0 null LAG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37827 GSE126345_7_v_10_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null PMC7412812-13059_2020_2115_MOESM9_ESM.xlsx-Negative_correlation-Also_present_in_upregulated_set_in_SERBP1_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null Vitelline envelope COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.644 Lung adenocarcinoma_LUAD_TCGA-44-6148-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Distal dendrite COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.73 ZNF625 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76967 PMC12913833-12672_2026_4481_MOESM3_ESM.xlsx-Table_S1-Table_S1_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null MYOD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.598 H3K27me3_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.684 H3K27me3_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VEZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7305 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KDM5B ENCODE Transcription Factor Targets 1.0 null GSE173873_10_v_3_stra8_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE249714_0_v_1_anxa1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84026 MZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.63991 increased hemoglobin content MGI Mouse Phenotype Associations 2023 1.0 null Perturb_3768_KD_PSDM13_SRP042158 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-T5JC-0008-SM-4DM6A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23278 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null EBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75615 Uterine Carcinosarcoma_UCS_TCGA-QM-A5NM-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBM43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28695 UCSD-242L Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.929678 HARA CCLE Cell Line Gene Expression Profiles 1.0 1.73359 OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.65446 hsa-miR-2115 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 REST-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041479 GTEX-PVOW-0011-R3A-SM-32PKX GTEx Tissue Sample Gene Expression Profiles 1.0 1.52436 SOCS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00165 SDHC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65443 NCIH1355 CCLE Cell Line Gene CNV Profiles 1.0 2.04466 GTEX-QDT8-0226-SM-32PL4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50346 Autosomal dominant disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.006 HB-06-WU12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.218706 fallopiantube_8c HPA Tissue Sample Gene Expression Profiles 1.0 1.22692 fallopiantube_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.06185 TENT5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13383 H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE161800_0_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A7WH-01A-22R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.834971 medial trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10554 H3K4me3_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null lateral spiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.00348 GTEX-R55F-1426-SM-2TF53 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46589 FZD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56835 MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.855353 SUSD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.95858 ADAM33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80357 CNNM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88842 H3K27me3_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU216 DepMap CRISPR Gene Dependency 1.0 5.32577 ChIP_RCOR3_21632747 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null PMC11067031-pnas.2317690121.sd06.xlsx-gene_list_14_txt-Differentially_expressed_genes_between_PML_RARA_GFP_vs_C88A_PML_RARA_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WVLH-3126-SM-3MJGA GTEx Tissue Sample Gene Expression Profiles 1.0 1.16082 GTEX-WOFM-0005-SM-3MJF3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.831551 Peripheral_Blood_Mononuclear_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.956769 inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.84919 COX6A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0684 GSE187006_3_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GFER CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47354 v91 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.542 COX7C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16364 HCC1897 CCLE Cell Line Gene Expression Profiles 1.0 1.65011 SYT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9831 spinalcordupper BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.900772 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.4532 GTEX-QVUS-0011-R4A-SM-3GAE7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.873006 Dentate granule cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.622 FB-39-CW59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.537456 ZKSCAN5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.7659 SF767 CCLE Cell Line Gene Expression Profiles 1.0 1.35673 GTEX-Q2AH-0008-SM-48U2J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78864 Primary somatosensory area, trunk, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10464 globus pallidus, internal segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.892368 GSE221327_5_v_9_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null Uterine Carcinosarcoma_UCS_TCGA-NA-A4R0-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GRM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.38484 UBXN11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41911 Perturb_12364_KD_SON_SRP268983 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.12319 Small Intestine - Terminal Ileum GTEx Tissue Gene Expression Profiles 2023 1.0 1.26213 inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.88794 HCC1428 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.898994 MTF2-20144788-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null ZNF707 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.5514 PMC11953390-41598_2025_94761_MOESM1_ESM.xlsx-Table_S3-Table_S3_The_result_of_MR_analysis_and_sensitivity_analysis_for_CKD_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GSE235596_0_v_1_pikfyve_mouse RummaGEO Gene Perturbation Signatures -1.0 null EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.53277 GTEX-QVUS-0626-SM-447CC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.971678 potassium ion transmembrane transport GO Biological Process Annotations 2015 1.0 null CORL51 CCLE Cell Line Gene Expression Profiles 1.0 1.82089 CNPY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40816 RASSF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27309 NTRK2_drugactivation_66_GSE20358 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 0.760092 GTEX-R55C-0008-SM-48FCF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.971911 Mafg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 36.0734 COLO-792 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZNF282 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.548 brain HPA Tissue Gene Expression Profiles 1.0 1.81922 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FBXL16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93405 EZH2 ENCODE Transcription Factor Targets 1.0 null EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null voltage-gated sodium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.789 astrocytoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.264011 GSE168676_2_v_3_dach1_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.852399 U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.56281 GTEX-S7SE-0011-R6A-SM-2XCD9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05906 LNZTA3WT4 DepMap CRISPR Gene Dependency 1.0 4.75853 FANCE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.622 H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XQ3S-0008-SM-4GIDZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63581 RABEP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06203 limbic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.533065 GTEX-PWCY-0426-SM-48TCW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.875639 CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE227891_5_v_0_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K27me3_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PDK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36015 FERMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.37413 ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.261336 GSE211983_1_v_3_nicotine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-T2IS-0011-R3A-SM-32QPB GTEx Tissue Sample Gene Expression Profiles 1.0 1.40329 PMC9843885-40478_2023_1507_MOESM6_ESM.xlsx-CIC-OE_TS603-Unnamed_1_CIC Rummagene Transcription Factor Associations 2026 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7079-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NAA20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46851 GTEX-QDT8-2926-SM-32PKC GTEx Tissue Sample Gene Expression Profiles 1.0 1.55492 GTEX-T5JC-0011-R4A-SM-32PLT GTEx Tissue Sample Gene Expression Profiles 1.0 1.22529 GSE195663_0_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null POU5F1-18358816-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GSE148692,GSE148695_5_v_6_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.916947 POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QVJO-0011-R4A-SM-2S1QL GTEx Tissue Sample Gene Expression Profiles 1.0 1.11652 CTDSPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93333 GSE192513,GSE192515_1_v_0_atg16l1_mouse RummaGEO Gene Perturbation Signatures -1.0 null cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2294 SLC39A14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89245 MORF4L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34164 H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 23132/87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.84095 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.974524 GTEX-X88G-0008-SM-47JWN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32028 SARS-ddORF6_84Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.88543 C11orf58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1909 GTEX-S32W-1126-SM-4AD5V GTEx Tissue Sample Gene Expression Profiles -1.0 -1.72981 MZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.957822 T84 CCLE Cell Line Gene CNV Profiles 1.0 1.41319 GSE210885_2_v_1_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null KLF15 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 85.1713 GTEX-QEL4-0008-SM-447AZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77044 hyperactivity IMPC Knockout Mouse Phenotypes 1.0 null GTEX-XUZC-2126-SM-4BRW8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04913 RAB43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92933 organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.219398 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null P4HTM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40196 abnormal GeneRIF Biological Term Annotations 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A183-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RNF126 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.11025 USF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12864_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EJ-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null orbital frontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.993796 GTEX-XLM4-0008-SM-4AT4W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.960413 PAFAH1B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82857 monovalent inorganic cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null MCF-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02417 DMS 273 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.04526 H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2848-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WC-09-GD62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20397 GTEX-S4Q7-0008-SM-3NM8A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01824 Perturb_16509_OE_Yap1_SRP314492 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.85368 Primary somatosensory area, lower limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.7129 Breast_Myoepithelial_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.923929 oocyte BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23478 PRPF38A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.69121 H3K27me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Spinal Cord Injury_CNS - Spinal Cord (MMHCC)_GSE16710 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.70677 myeloid progenitor cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.072754 POU5F1-16518401-CHIP-PET-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC9882185-media-4.xlsx-Neuron_KD-ID_AR Rummagene Transcription Factor Associations 2026 1.0 null NUDHL1 CCLE Cell Line Gene CNV Profiles 1.0 1.86861 MXI1 ENCODE Transcription Factor Targets 1.0 null ZFP14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 96.6656 PSMB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64333 Perturb_15702_KD_AGE_SRP353924 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -15.5995 TCF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.1217 GTEX-SUCS-1826-SM-32PM1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.869491 A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_7day-MOI-10^4_None_GSE43301 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.69539 Rectum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 LRRC57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73521 substrate-specific transporter activity GO Molecular Function Annotations 2015 1.0 null GTEX-QV31-1326-SM-2S1QE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13958 SPEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80881 FHL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63592 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.11657 GSE107505_3_v_2_nanog_mouse RummaGEO Gene Perturbation Signatures -1.0 null SARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58551 NUGC-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.26557 GSE68156_3_v_4_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null dorsolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.850328 CTCF_GM19240_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebral lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.575616 GSE142210_4_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null VZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.970295 NFKB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.7723 CHD7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AG-0011-R1A-SM-2HMJI GTEx Tissue Sample Gene Expression Profiles 1.0 1.78468 POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.1777 496100391_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.75697 H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.449 H3K9me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cerebellum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.84986 fallopiantube_8d HPA Tissue Sample Gene Expression Profiles 1.0 1.64998 PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S7SE-0011-R5A-SM-2XCDA GTEx Tissue Sample Gene Expression Profiles 1.0 1.19762 H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GATA-1_KD_GDS1245_81_mouse_megakaryocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JJN3 Achilles Cell Line Gene Essentiality Profiles 1.0 1.08648 r2 part of trigeminal sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01717 esophagus_5c HPA Tissue Sample Gene Expression Profiles -1.0 -0.971719 NCI-H226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.986875 GSE203429_0_v_1_angptl8_human RummaGEO Gene Perturbation Signatures 1.0 null CRY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94589 Acute Myeloid Leukemia_LAML_TCGA-AB-2837-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ODF2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15979 CYREN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98769 A-VN-1203-2004(H5N1)_Day1-10^3pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.44628 GTEX-WL46-0011-R7A-SM-3LK7X GTEx Tissue Sample Gene Expression Profiles 1.0 1.43649 H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lymphatic edema_Skin tissue_GSE4333 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.46737 CAR-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.04526 H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null 17312329-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null receptor activity GO Molecular Function Annotations 2015 1.0 null GTEX-N7MS-0008-SM-4E3JI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13584 connective tissue cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.059665 Axon initial segment COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.997 GSE232218_1_v_0_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null KLF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 100.18 BCDIN3D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.19887 Prelimbic area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45792 Prelimbic area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00602 GSE101239_5_v_0_valproic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null AOB, outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26887 superficial stratum of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16023 RINL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93879 C19orf81 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22936 NFE2L2_02_174 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.90689 Olfactory cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.547 ABI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82867 VBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71781 Heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.106 abnormal cns synaptic transmission MPO Gene-Phenotype Associations 1.0 null SOX9-25088423-EMBRYONIC GONADS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null SKCO1 Achilles Cell Line Gene Essentiality Profiles 1.0 1.59084 Perturb_8842_KD_ESRRA_SRP254908 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 POU5F1 ChEA Transcription Factor Targets 1.0 null C8166 DepMap CRISPR Gene Dependency 1.0 3.0087 ERA-27197147-CHIP-SEQ-ENDOMETRIOID-ADENOCARCINOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.58545 HT COSMIC Cell Line Gene Mutation Profiles 1.0 null EPN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81689 PMC11336098-41598_2024_70235_MOESM1_ESM.pdf-169-IKZF4_IKZF4 Rummagene Transcription Factor Associations 2026 1.0 null RREB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 167.909 ACSM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.16653 SKMM2 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.34581 FURIN_Deficiency_GDS3512_568_mouse_T-cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-WL46-0011-R5A-SM-3LK6V GTEx Tissue Sample Gene Expression Profiles 1.0 1.36446 CACNG6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60152 GSE229914_2_v_3_keap1_human RummaGEO Gene Perturbation Signatures 1.0 null HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36692 increased circulating free fatty acids level IMPC Knockout Mouse Phenotypes 1.0 null intermediate stratum of PcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.08476 H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CAL-120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.41617 K-562 COSMIC Cell Line Gene Mutation Profiles 1.0 null ISG15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9801 H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE111102,GSE111105_3_v_0_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE175787_8_v_9_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RNOR-2326-SM-2TF4I GTEx Tissue Sample Gene Expression Profiles 1.0 2.04127 HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.29606 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2916-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null phosphate-containing compound metabolic process GO Biological Process Annotations 2015 1.0 null OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.52651 Mesothelioma_MESO_TCGA-SH-A7BD-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell part LOCATE Curated Protein Localization Annotations 1.0 null H3K27me3_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null CD248 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90024 GB-46-CK08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.263235 cation transport GO Biological Process Annotations 2015 1.0 null GSE175787_13_v_0_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_1368_KD_IGF2BP2_SRP252209 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.92504 DF-84-RT50_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.624698 GSE210885_0_v_1_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null Anteromedial visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62643 PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-U3ZM-0826-SM-4DXU6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.901834 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SNU475 DepMap CRISPR Gene Dependency 1.0 4.35631 NCIH660 CCLE Cell Line Gene CNV Profiles -1.0 -1.51452 CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.992288 GSE226316_0_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC6335596-mmc2.xlsx-RNA-seq_Day_12_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_12_in_RNA-seq_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null SYNGR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42307 L2HGDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3697 NERISPIRDINE DGIdb Drug Targets 2026 1.0 0.151234 NCI-H2291 COSMIC Cell Line Gene Mutation Profiles 1.0 null EGR1 ENCODE Transcription Factor Targets 1.0 null HEXIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78658 inorganic cation transmembrane transport GO Biological Process Annotations 2023 1.0 null GSE118490_1_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RNF2 ENCODE Transcription Factor Targets 1.0 null stratum lacunosum-moleculare of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.91104 intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041047 Molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.824 POLR2A_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OIP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.17955 signal transducer activity GO Molecular Function Annotations 2015 1.0 null NCI-H2722 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.2208 GSE200673,GSE200691_2_v_3_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE153189_2_v_3_interferon gamma_mouse RummaGEO Drug Perturbation Signatures 1.0 null signaling receptor activity GO Molecular Function Annotations 2015 1.0 null GSE163920_1_v_0_sirt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QVJO-0011-R2A-SM-2S1QK GTEx Tissue Sample Gene Expression Profiles 1.0 1.51946 Perturb_13490_KD_Ncor1_ERP132013 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 17.8069 GTEX-Q2AG-0011-R10A-SM-2HMLA GTEx Tissue Sample Gene Expression Profiles 1.0 1.70739 H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-91-6835-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZEB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.488 USP20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5904 dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.834971 CiliaryGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.33323 superficial stratum of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11867 GSE148066,GSE157787_0_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.028593 cell periphery COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GSE199092_2_v_0_ddx5_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF613 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6479 PMC9928584-41556_2022_1059_MOESM3_ESM.xlsx-Table_8-Supplementary_Table_8_ETV6-repressed_genes_defined_by_dTAG_at_72_hours_ETV6 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_8883_KD_CSL_SRP142324 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.04915 myeloblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.444499 GSE154081_1_v_0_sildenafil_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-NL4W-0011-R4a-SM-2I5GZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.13488 H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NFK9-0326-SM-3MJGV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827212 ovary TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056376 Nucleus of the trapezoid body Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 4.44139 NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11865 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F0-06A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE242199_6_v_5_ntrk2_human RummaGEO Gene Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6934-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null single-organism transport GO Biological Process Annotations 2015 1.0 null DorsalRootGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.0221 COR-L23 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE142210_9_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-S32W-2226-SM-2XCAY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.72252 layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.839741 GTEX-NL3H-0008-SM-4E3HU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02082 H3K27me3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOS ENCODE Transcription Factor Targets 1.0 null FOXI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52635 PMC2860895__F1 PFOCR Pathway Figure Associations 2024 1.0 null MANEA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62891 Perturb_14715_KO_Tbx3_SRP305624 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.37603 COR-L47 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null PMC7334247-12031_2020_1490_MOESM2_ESM.xls-THAP1_S21T_vs_wt-Gene_Symbol_THAP1 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE168797_2_v_5_cannabidiol_human RummaGEO Drug Perturbation Signatures -1.0 null BB-62-SZ35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.448791 TTLL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71007 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U8XE-1026-SM-4E3HM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.844724 TP53INP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50587 plagl2_17983586_small_intestine_lof_mouse_gpl1261_gds3010 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.248369 superficial stratum of m1AD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4011 GTEX-WZTO-2926-SM-3NM9I GTEx Tissue Sample Gene Expression Profiles 1.0 1.91748 RIC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33065 TMEM175 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92331 thyroid BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.06168 Infralimbic area, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44745 NCIH2106 CCLE Cell Line Gene CNV Profiles -1.0 -1.65143 skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -1.85091 CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ANKRD35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48034 GSE60217_1_v_2_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null TGFBR1_activemutant_291_GSE14523 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.74606 Seminal vesicle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 SMG7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80993 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null glial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.257237 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-BI-A0VS-01A-11R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZIC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12611 RNF2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100436_FWM_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.95829 FMNL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1481 GTEX-X4XX-0011-R3B-SM-46MWK GTEx Tissue Sample Gene Expression Profiles 1.0 1.31015 Potassium Channels Reactome Pathways 2024 1.0 null deep layers of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3823 GTEX-S341-2026-SM-2XCAA GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 GSE111102,GSE111105_1_v_0_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsolateral part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09519 H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null primordium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.256234 PGBD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28769 GTEX-XUZC-2026-SM-4BRW9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37366 CTCF_BE2C_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFIC ENCODE Transcription Factor Targets 1.0 null Brain_Germinal_Matrix Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.865506 Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QZ-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-UZ-A9PL-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-1909 TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 cortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.828454 optic fiber layer of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.85219 NHLH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.5722 CEP85 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35077 primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.933503 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EZH2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-P6-A5OF-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8010-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUZ12_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_2990_KO_UTX_SRP108473 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.22683 RASD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.37348 EIF4G3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13021 NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.902682 HAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40105 GTEX-XLM4-0011-R10A-SM-4AT5P GTEx Tissue Sample Gene Expression Profiles 1.0 1.45557 CLEC14A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0248 mantle zone of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12126 ADAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21504 PMC11462941-CAS-115-2947-s001.pdf-175-ZGLP1_ZGLP1 Rummagene Transcription Factor Associations 2026 1.0 null PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_1_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null localization GO Biological Process Annotations 2015 1.0 null GTEX-Q2AH-1626-SM-3GAF8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.73267 MCF7 Achilles Cell Line Gene Essentiality Profiles 1.0 1.23086 Bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE181517_2_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null HCC12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null lateral (parvicellular) part of MD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.69475 H3K27me3_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AC-84-QG99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.349474 HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.916947 PMC11390959-41598_2024_70075_MOESM3_ESM.xlsx-520_DMD_common_down_gene_list-HES4_HES4 Rummagene Transcription Factor Associations 2026 1.0 null hippocampus (hippocampal formation)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07005 CTCF_GM13977_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE157894_1_v_0_cystine_human RummaGEO Drug Perturbation Signatures -1.0 null TCCSUP Achilles Cell Line Gene Essentiality Profiles -1.0 -1.40395 H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Retrosplenial area, lateral agranular part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55521 HOP-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.992288 MAST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.174 H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IGR37 CCLE Cell Line Gene CNV Profiles -1.0 -1.77013 membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.6067 soft tissue HPA Tissue Protein Expression Profiles -1.0 -1.10836 Primary somatosensory area, trunk Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03512 JD-44-KF86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.222475 GSE168797_2_v_0_cannabidiol_human RummaGEO Drug Perturbation Signatures -1.0 null SNIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47158 TRAPPC6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37116 CCNK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74991 Leukemia, Acute Megakaryocytic_Megakaryocyte_GSE2433 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.02657 seizures MPO Gene-Phenotype Associations 1.0 null GTEX-WHSE-3126-SM-3P5ZI GTEx Tissue Sample Gene Expression Profiles 1.0 0.90728 KLF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 78.9993 ZNF331 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.4016 anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05223 Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ADAMTSL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8055 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CD-35-BD44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.349648 NCIH3122 DepMap CRISPR Gene Dependency 1.0 5.64381 PMC7914369-thnov11p3676s2.xls-BPTF-KOvsCtrl-AccID_BPTF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PVOW-0011-R5A-SM-32PL7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02989 brain_a HPA Tissue Sample Gene Expression Profiles 1.0 2.24332 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 15750623-SuppTable1b GeneSigDB Published Gene Signatures 1.0 null monovalent inorganic cation transport GO Biological Process Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-7667-01A-31R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AIF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9415 RHOQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70372 AKT_UP_MTOR_DN.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null GSE162739_4_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null MYDGF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01638 GTEX-XLM4-0226-SM-4AT4N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00951 KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2432 KLF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 112.855 GSE226316_4_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null NTRK3_drugactivation_67_GSE20358 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 0.760092 GTEX-SN8G-0008-SM-4DM4X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02319 H3K27me3_cardiac mesoderm_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2-27294783-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null REST_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null M-1 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.20797 CLSTN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41164 Main olfactory bulb, granule layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.00689 GSE156454_0_v_1_tamoxifen_human RummaGEO Drug Perturbation Signatures 1.0 null VAX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70224 Posterior parietal association areas, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50788 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null AA-22-UI44_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.204713 MDAMB436 CCLE Cell Line Gene CNV Profiles -1.0 -1.57415 H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NFIX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.3907 GSE227592_0_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-UTHO-3026-SM-3GAFB GTEx Tissue Sample Gene Expression Profiles 1.0 1.35021 CL-34 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-QDVJ-0726-SM-48U1W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38862 potassium ion transport GO Biological Process Annotations 2023 1.0 null Erectile dysfunction_Penis Erectile Tissue_GSE2457 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.8977 GSE141624_3_v_0_cocaine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-VJYA-1326-SM-3GIJC GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 NCIH716 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.08787 Prelimbic area, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39281 GTEX-PW2O-1926-SM-2S1OB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10336 MLLT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68751 GTEX-NPJ8-1526-SM-2D7VU GTEx Tissue Sample Gene Expression Profiles 1.0 1.45948 GTEX-WZTO-0011-R4A-SM-3NMC7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.73351 GTEX-TSE9-0011-R1A-SM-3DB7E GTEx Tissue Sample Gene Expression Profiles 1.0 1.1323 GSE65617_2_v_3_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_2_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null SW1271 COSMIC Cell Line Gene Mutation Profiles 1.0 null NAP1L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25334 H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE126345_4_v_3_hcrt_mouse RummaGEO Gene Perturbation Signatures -1.0 null SMTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95441 GTEX-QDT8-0008-SM-48U2F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.881324 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12875_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JHOS4 CCLE Cell Line Gene Expression Profiles -1.0 -1.45446 Perturb_14722_KO_Bma1_SRP351647 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.34415 H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ChIP_RNF2_22325148 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-Q2AG-0008-SM-48U2K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46251 PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A Rummagene Transcription Factor Associations 2026 1.0 null rosiglitazone_mus musculus_gpl7202_gse19896 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 496100416_FWM_dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.05711 GTEX-WHSE-0011-R1A-SM-3P5ZK GTEx Tissue Sample Gene Expression Profiles 1.0 1.30133 G-402 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.905026 CHRNB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20512 SNAI2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7486 CD33+_Myeloid BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.27694 PMC12019336-41467_2025_58868_MOESM5_ESM.xlsx-Open_peaks_IKAROS_WT-Unnamed_5_IKZF1 Rummagene Transcription Factor Associations 2026 1.0 null H3K27me3_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETV7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.6828 ALG8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64845 FUNDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.05659 TE6 DepMap CRISPR Gene Dependency 1.0 2.05425 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A728-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUZ12-18974828-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MAP3K20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34614 Plagl1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.1705 mediodorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28552 primary motor cortex (area M1, area 4)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.897251 POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPN-0008-SM-4E3HW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24057 Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A5BI-01A-31R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IGDCC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46293 GTEX-T6MN-2526-SM-32PMN GTEx Tissue Sample Gene Expression Profiles 1.0 1.00257 GTEX-P44H-0011-R10A-SM-2XCEK GTEx Tissue Sample Gene Expression Profiles 1.0 1.17394 H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CENPS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73286 GSE94814_2_v_3_reck_mouse RummaGEO Gene Perturbation Signatures -1.0 null SLC35E3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3758 H3K4me1_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF574 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 71.0087 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null bonemarrow BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.08063 LRSAM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98469 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4QS-1826-SM-2S1NI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.950472 Cyclic AMP HMDB Metabolites of Enzymes 1.0 null STEAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79738 GTEX-N7MT-1026-SM-3TW8T GTEx Tissue Sample Gene Expression Profiles 1.0 0.996476 SMAD4-21741376-HESC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null MSH4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44819 blast cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069359 H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Perturb_8848_KD_APC_SRP267478 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.48672 PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1 Rummagene Transcription Factor Associations 2026 1.0 null H3K27me3_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.445653 HEY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26964 GSE158743_1_v_2_nfkbia_human RummaGEO Gene Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H2-01A-12R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EIF3I CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28445 superficial stratum of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02843 OUMS23 DepMap CRISPR Gene Dependency 1.0 4.12699 BE-79-QU25_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.316265 PMC10247733-41408_2023_863_MOESM4_ESM.pdf-574-ZSCAN1_ZSCAN1 Rummagene Transcription Factor Associations 2026 1.0 null NCIH69 CCLE Cell Line Gene Expression Profiles 1.0 2.63835 ERF::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.6722 Short QT syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.215 Brain Lower Grade Glioma_LGG_TCGA-HT-A5R7-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE147283_1_v_3_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null H3K27me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of cardiac morphology GWASdb SNP-Phenotype Associations 1.0 0.866894 HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.03864 cellular metabolic process GO Biological Process Annotations 2015 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5KT-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96804 Accessory olfactory bulb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41366 NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.01665 MBD3L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80658 GATA2_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KIAA2013 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22077 H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE142210_2_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Peripheral vertigo DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.304 NACC1 ChEA Transcription Factor Targets 1.0 null DST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42859 COPG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69726 H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SMAD2/3-21741376-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ZNF69 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62098 TIMM44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2015 GSE210682_2_v_1_methadone_human RummaGEO Drug Perturbation Signatures -1.0 null BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TDRD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96176 H2BC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95119 GSE111660_4_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null ATP6V0C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24896 NFIB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.5906 DUSP26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56904 H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SKMEL19 DepMap CRISPR Gene Dependency 1.0 2.14592 GSE162739_8_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-X4XY-0526-SM-46MW1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.943674 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZA-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RCOR3-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.007 GSE153867_6_v_8_olaparib_human RummaGEO Drug Perturbation Signatures -1.0 null KPNRTBM1 CCLE Cell Line Gene Expression Profiles -1.0 -1.51155 EP300 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9591 GSE79663_2_v_0_tcf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null PRDM9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 219.998 OE-31-YC41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.301297 GSE145915_5_v_1_pcm1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SU8686 CCLE Cell Line Gene CNV Profiles -1.0 -1.54521 GSE234289_3_v_0_rfx6_human RummaGEO Gene Perturbation Signatures -1.0 null Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.23424 nervous system phenotype MPO Gene-Phenotype Associations 1.0 null C5orf15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12092 Voltage gated Potassium channels Reactome Pathways 2014 1.0 null abnormal CNS synaptic transmission MGI Mouse Phenotype Associations 2023 1.0 null GSE131425_2_v_3_arg2_mouse RummaGEO Gene Perturbation Signatures -1.0 null KURAMOCHI Achilles Cell Line Gene Essentiality Profiles 1.0 1.46693 Primary somatosensory area, lower limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.98033 GSE142630_0_v_2_hiltonol_human RummaGEO Drug Perturbation Signatures -1.0 null testis_7e HPA Tissue Sample Gene Expression Profiles 1.0 0.97678 H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SUZ12-18692474-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null NCI-H1155 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE226316_3_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures 1.0 null voltage-gated cation channel activity GO Molecular Function Annotations 2015 1.0 null LXF-289 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PDCD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36035 21205295-TableS1 GeneSigDB Published Gene Signatures 1.0 null FRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88601 ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.813476 Entrectinib_A-427 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.00738584 MDA-MB-435S cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.848 PMC11772884-41421_2024_747_MOESM6_ESM.xlsx-8_DEGs_RUNX1-OE_vs_control-Gene_Symbol_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null EZH2 ChEA Transcription Factor Targets 1.0 null HOP-92 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.01542 HMG20A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64166 GTEX-NL3H-0011-R4a-SM-2I3GK GTEx Tissue Sample Gene Expression Profiles 1.0 1.18246 abdomen TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.138911 GSE167004_0_v_3_thpo_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XBED-2626-SM-4E3J5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23426 TE159T CCLE Cell Line Gene Expression Profiles -1.0 -2.46061 GSE57871_6_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XMK1-0008-SM-4GICF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06765 Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAHD2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41127 H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GSE206516,GSE206518_3_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OXRN-0011-R10A-SM-2I5GC GTEx Tissue Sample Gene Expression Profiles 1.0 1.16894 Perturb_16518_KD_Pou2f3_SRP343255 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WL46-0011-R1A-SM-3LK6M GTEx Tissue Sample Gene Expression Profiles 1.0 1.6234 Rectum adenocarcinoma_READ_TCGA-EI-6513-01A-21R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WHSE-0011-R5A-SM-3P5ZO GTEx Tissue Sample Gene Expression Profiles 1.0 1.29587 TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.8847 GTEX-T2YK-0008-SM-4DM6M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.862679 brucellosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.770027 GTEX-XMK1-2226-SM-4B673 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45435 EGR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16201 AD-51-FB60_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.215638 GTEX-S7SE-0011-R10A-SM-2XCDF GTEx Tissue Sample Gene Expression Profiles 1.0 1.53113 Sarcoma_SARC_TCGA-WP-A9GB-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null voltage-gated monoatomic cation channel activity GO Molecular Function Annotations 2023 1.0 null BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.301676 CTCF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE108495_1_v_2_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.379 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DCLRE1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82504 ZNF121 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55748 PMC11046918-12967_2024_5211_MOESM5_ESM.xlsx-C_FUS-DDIT3-eGFP_vs_eGFP-Table_S3_Regulated_genes_between_scaffold-cultured_HT1080_FUS_DDIT3-eGFP_cells_and_control_cell_lines_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null Anterior olfactory nucleus, external part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43449 DG-75 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-T2IS-3026-SM-32QPM GTEx Tissue Sample Gene Expression Profiles 1.0 2.04182 GSE65617_5_v_3_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_2131_KD_HAPSTR1_SRP377309 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.50622 ventrolateral prefrontal cortex_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.833211 CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMD1-0011-R6A-SM-4AT5K GTEx Tissue Sample Gene Expression Profiles 1.0 0.833836 TC205 DepMap CRISPR Gene Dependency 1.0 2.16387 GSE90019,GSE90020_5_v_2_phf8_mouse RummaGEO Gene Perturbation Signatures -1.0 null NUP214 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38092 ChIP_POU5F1_18358816 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null ADAMTS16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47517 GSE234340_3_v_7_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22552 PMC10042887-41419_2023_5742_MOESM3_ESM.xlsx-Table_S3-Table_S3_Differently_expressed_genes_in_HOXB3_vs_HOXB3-_aPCA_HOXB3 Rummagene Transcription Factor Associations 2026 1.0 null plasma membrane LOCATE Curated Protein Localization Annotations 1.0 null GSE133213_6_v_3_znrf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_cerebellum_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.929678 FAU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03947 GSE133329_0_v_3_trim28_human RummaGEO Gene Perturbation Signatures 1.0 null membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.289569 GTEX-WVLH-0011-R2A-SM-3MJFJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.48457 Posterior parietal association areas, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49711 TFPT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30625 abnormality of the cardiovascular system GWASdb SNP-Phenotype Associations 1.0 0.052402 CCDC136 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54148 SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.838104 ChIP_REST_21632747 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-regulation_of_membrane_potential_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null RGL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74888 ZFYVE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99046 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SUZ12_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH322 CCLE Cell Line Gene Expression Profiles -1.0 -1.77213 H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null motor GeneRIF Biological Term Annotations 1.0 null GSE139239_2_v_5_ddr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PPIF_KO_GSE23028_45_mouse_heart (8 wk) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GUANIDINE HYDROCHLORIDE DGIdb Drug Targets 2026 1.0 0.189043 testis_7f HPA Tissue Sample Gene Expression Profiles 1.0 0.830334 GSE42805,GSE42811_1_v_0_cocaine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QDVN-0008-SM-48U2D GTEx Tissue Sample Gene Expression Profiles -1.0 -0.943686 PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_13_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null ACTA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63136 NCI-H2122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.903328 GTEX-NL3H-0011-R3a-SM-2I3GL GTEx Tissue Sample Gene Expression Profiles 1.0 1.14451 P31-FUJ COSMIC Cell Line Gene Mutation Profiles 1.0 null OTUD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31004 GTEX-WFG8-2426-SM-3GILL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.988141 RPL36A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96495 GSE57871_5_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Primary somatosensory area, upper limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10665 PSMA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60098 GSE189683_1_v_2_rif1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF281 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 170.51 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RING1B-27294783-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null LRCH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55599 Olfactory areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02725 H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H82 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.19195 FA-36-VA24_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.51135 PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Baboon_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null CDX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38942 H3K27me3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_12175_Mut_PLK4_ERP132994 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -9.18003 GTEX-T2IS-3126-SM-32QPK GTEx Tissue Sample Gene Expression Profiles 1.0 1.16874 AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.789523 TCF12 ENCODE Transcription Factor Targets 1.0 null CTCF_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.69453 SRSF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47866 posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05315 496100484_FWM_no dementia_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.72697 ZSWIM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60299 dysfunction GeneRIF Biological Term Annotations 1.0 null Autosomal dominant nonsyndromic deafness 2A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.964 Urinary bladder smooth muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.318 GTEX-T5JC-0011-R10A-SM-32PM2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.97551 GSE146982_4_v_6_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null TNRC6C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.42013 Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ARID3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95479 GSE131161_1_v_0_rarres1_mouse RummaGEO Gene Perturbation Signatures -1.0 null voltagegated GeneRIF Biological Term Annotations 1.0 null H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6022-01A-21R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE57397,GSE57399_1_v_0_fbxw7_human RummaGEO Gene Perturbation Signatures -1.0 null stratum pyramidale of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07317 MED14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73641 PRDX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31743 GTEX-R55G-2326-SM-2TC61 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 Brain Lower Grade Glioma_LGG_TCGA-DU-7292-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WL46-3026-SM-3LK7Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.40433 GSE154074_5_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K23me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-QMR6-0011-R1A-SM-32PKW GTEx Tissue Sample Gene Expression Profiles 1.0 0.87515 GSE178714_3_v_0_smad2_human RummaGEO Gene Perturbation Signatures 1.0 null RIDA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5089 MTF2 ChEA Transcription Factor Targets 1.0 null Mood disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.038 layer 1 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09871 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STRADA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02117 GSE172146_2_v_0_mettl1_human RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U8XE-0826-SM-4E3J1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07915 hsa-miR-1289 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GSE218580_1_v_0_fentanyl_mouse RummaGEO Drug Perturbation Signatures -1.0 null TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null COR-L32 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-OXRN-2626-SM-48TBX GTEx Tissue Sample Gene Expression Profiles 1.0 0.979135 THP1 CCLE Cell Line Gene CNV Profiles -1.0 -2.89287 CTCF_MCF-7_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-0011-R7A-SM-3DB7P GTEx Tissue Sample Gene Expression Profiles 1.0 0.836959 KLF5 JASPAR Predicted Transcription Factor Targets 1.0 null Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.602 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_2_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-N7MT-0011-R10A-SM-2I3E1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22625 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Supplementary_Table_2D_Contrast_ATF4-def_Tg_2h_vs_HCT116Tg_2h_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null hiv1 GeneRIF Biological Term Annotations 1.0 null DPP3_OE_GDS2653_650_human_IMR-32 neuroblastoma cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Periglomerular cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.719 SUM185PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.952872 RSRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24679 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LHFPL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12934 GSE219195_4_v_5_rbm12_human RummaGEO Gene Perturbation Signatures 1.0 null GTF3C2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27904 endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050677 CH157MN CCLE Cell Line Gene Expression Profiles 1.0 1.60514 MTOR_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null GSE137702_2_v_1_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null voltage-gated monoatomic cation channel activity GO Molecular Function Annotations 2025 1.0 null H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null KYSE-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.973611 ventrolateral prefrontal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.933348 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE87144_3_v_1_rorc_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE231648_4_v_2_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null OB granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43859 ALDH1B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99777 PMC9822887-41598_2022_27261_MOESM10_ESM.xlsx-HCT116_overlap_TCF7L2_CTNNB1_lo-Unnamed_1_TCF7L2 Rummagene Transcription Factor Associations 2026 1.0 null Anterior cingulate area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06209 GTEX-XLM4-3126-SM-4AT6M GTEx Tissue Sample Gene Expression Profiles 1.0 1.14009 WDR86 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87302 GSE175787_13_v_7_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-UTHO-1826-SM-3GAFE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06773 PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T6MN-2726-SM-4DM77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20814 GSE119978,GSE180930_2_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Secondary motor area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33502 GINS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22724 BGC823 CCLE Cell Line Gene CNV Profiles 1.0 1.54061 synovium cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.685491 NDUFS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18255 CTCF_MEL cell line_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10187 GTEX-T6MN-0011-R10A-SM-32QP7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.81524 GTEX-NPJ8-0226-SM-48TBN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.985354 SRP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04179 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE227592_10_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null HCC1954 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.91597 Perturb_2324_KD_SF3A1_SRP268983 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.87933 Koelliker-Fuse nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00589 NO11 DepMap CRISPR Gene Dependency 1.0 2.93589 MTIF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91069 PNPO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94019 GTEX-OHPK-0008-SM-4E3JL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.936374 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null immune system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.245747 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_InDel-F5-Pneo-r__CIC-1n_h-r__CIC-2n_h-r_CIC Rummagene Transcription Factor Associations 2026 1.0 null r11 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12398 PMC6080909-JEM_20171312_TableS1.xlsx-miR-196_predicted-Table_S1_miR-196a_b_predicted_targets_by_PITA_PicTar_TargetScan_and_DIANA_prediction_algorithms_ZFP1 Rummagene Transcription Factor Associations 2026 1.0 null JADE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.95961 GSE187006_0_v_1_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Cyclic nucleotide-binding-like InterPro Predicted Protein Domain Annotations 1.0 null abnormal nervous system physiology MPO Gene-Phenotype Associations 1.0 null NR5A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67849 GSE148692,GSE148695_1_v_0_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null MLH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41677 MRGBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17353 NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38799 Leukemia DisGeNET Gene-Disease Associations 1.0 null posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.83184 SG in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01148 CTCF_GM12872_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null r1 part of ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01953 LTO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98812 Intrinsic cardiomyopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.09 GSE175787_8_v_6_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null GSE173201_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19435 hESC_Derived_CD56+_Mesoderm_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.16 CTCF_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZKSCAN8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60027 Kidney Chromophobe_KICH_TCGA-KM-8639-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null establishment of localization GO Biological Process Annotations 2015 1.0 null H3K4me1_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null DPP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.322 TMCO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81012 Perturb_3779_KD_NFYA_SRP041162 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.4518 CACNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86941 Perturb_3340_KO_Cns4_SRP310440 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.75266 Lung adenocarcinoma_LUAD_TCGA-97-8552-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null UF-27-HS98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203002 496100277_FWM_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.36611 GTEX-XMD1-0008-SM-4AT41 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03959 CTCF_GM10266_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWOO-2026-SM-48TDE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.870659 icSARA deltaORF6_48Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.55566 Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null voltage-gated potassium channel activity GO Molecular Function Annotations 2025 1.0 null DU-145 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-SUCS-0726-SM-4DM7J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.98272 CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.534966 cation transmembrane transport GO Biological Process Annotations 2015 1.0 null GSE63048_11_v_6_morc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SLC25A13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03983 GTEX-Q2AG-0011-R5A-SM-2HMJH GTEx Tissue Sample Gene Expression Profiles 1.0 1.26403 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A195-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TSE9-0011-R10A-SM-3DB7O GTEx Tissue Sample Gene Expression Profiles 1.0 1.67707 WM793 CCLE Cell Line Gene CNV Profiles -1.0 -2.21762 CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142210_2_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null voltage-gated ion channel activity GO Molecular Function Annotations 2015 1.0 null H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.045076 NF-kappaB MotifMap Predicted Transcription Factor Targets 1.0 null GGCT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32591 posteroventral (inferior) parietal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.912074 GTEX-Q2AG-3026-SM-48U1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.02799 GSE217452_3_v_1_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null OCT4-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null lateral ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.977962 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GTEX-UPJH-0226-SM-3GADV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886219 Primary somatosensory area, mouth, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03701 cell-cell signaling GO Biological Process Annotations 2015 1.0 null H3K4me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE149035_7_v_0_hepacam_human RummaGEO Gene Perturbation Signatures 1.0 null MPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54159 olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0605 NFIC JASPAR Predicted Transcription Factor Targets 1.0 null H3K27me3_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_12356_KD_PRPF8_SRP268983 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.31908 GTEX-Q2AI-0008-SM-48U2H GTEx Tissue Sample Gene Expression Profiles -1.0 -0.993055 layer II of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.8435 posteromedial visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32947 H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -1.85091 SKNBE2 DepMap CRISPR Gene Dependency 1.0 3.19794 EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet2-intersection_DEGs_of_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null potassium ion transport GO Biological Process Annotations 2015 1.0 null H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of isLim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.0295 DAUDI COSMIC Cell Line Gene Mutation Profiles 1.0 null dorsal paracommissural tectal nucleus, m1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4011 GTEX-SSA3-0008-SM-47JWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.856269 KLF17 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 83.4365 TFAP2A JASPAR Predicted Transcription Factor Targets 1.0 null THAP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89102 H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB3L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.1 Perturb_821_OE_Rspo1_SRP325709 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GSE112714_2_v_0_ctnnb1_human RummaGEO Gene Perturbation Signatures 1.0 null CCNL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46479 NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36692 H3K27me3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ANGEL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95186 NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00392 CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE130246_1_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null ACVR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26718 CCDC9B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95649 SNU213 CCLE Cell Line Gene CNV Profiles -1.0 -1.34946 EZH2-23942234-MYOBLASTS-AND-MYOTUBES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null paralemniscal isthmic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.17774 GSE234514,GSE234516_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-U3ZN-2626-SM-3DB7T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.091 OLIG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.13044 Prostate adenocarcinoma_PRAD_TCGA-CH-5794-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC2A14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40145 hsa-miR-4319 TargetScan Predicted Conserved microRNA Targets 1.0 0.127531 synaptic transmission GO Biological Process Annotations 2015 1.0 null glioma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.270561 Neurosecretory cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.544 oocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.381003 VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.915758 MT-ATP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8797 DB-54-GQ68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.297141 DENND4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.07081 Brain Lower Grade Glioma_LGG_TCGA-HT-7856-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SE5C-0008-SM-4B64J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.927634 rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.989824 Brain Lower Grade Glioma_LGG_TCGA-DU-A7TC-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NRF2-20460467-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-X261-3226-SM-3NMC3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.853791 CEP170 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99639 ZNF845 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94613 EGR1-20690147-ERYTHROLEUKEMIA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GLIS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.1958 GSE178714_6_v_0_smad2_human RummaGEO Gene Perturbation Signatures 1.0 null NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-T6MN-2626-SM-32PMQ GTEx Tissue Sample Gene Expression Profiles 1.0 2.49525 protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041735 MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1623 COSMIC Cell Line Gene CNV Profiles 1.0 4.51153 GSE196835_0_v_1_ddx1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-R55D-0008-SM-48FEV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.998432 OC-314 COSMIC Cell Line Gene Mutation Profiles 1.0 null posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.835891 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29L-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07504 SUZ12-18692474-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ADM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27578 SMAD4-21741376-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTPBP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57506 H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PANC0327 DepMap CRISPR Gene Dependency 1.0 2.50461 PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S9-ZNF384_SpecDMCs-Unnamed_3_ZNF384 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-VUSH-0008-SM-47JWK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.837683 GTEX-U3ZM-1226-SM-3DB9G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.925872 Lung adenocarcinoma_LUAD_TCGA-38-A44F-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE146982_7_v_6_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null CNOT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70434 SP9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 76.9 AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null musculoskeletal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.056573 TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null TRUB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30151 GATA3-21867929-CD8-MOUSE ChEA Transcription Factor Targets 2022 1.0 null 496100362_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.66474 ERRFI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33874 ZBTB24 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 63.0423 S100A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74397 CCDC106 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81927 MED30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46039 Intelligence (MTAG) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.81549 Primary motor area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10787 GSE122378_0_v_1_carmil3_mouse RummaGEO Gene Perturbation Signatures -1.0 null TBL1X CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38313 CTCF_fibroblast of mammary gland_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE200430_1_v_0_sema3d_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_GM13976_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Anteromedial visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.97604 GTEX-P44H-0011-R5A-SM-2XCEX GTEx Tissue Sample Gene Expression Profiles 1.0 1.10835 SCAF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24783 CTCF_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8066 JVM3 CCLE Cell Line Gene CNV Profiles 1.0 1.5589 Perturb_3854_KO_ITPR3_SRP332879 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.72249 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE217363_6_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null STAT3 MotifMap Predicted Transcription Factor Targets 1.0 null GSE215086_0_v_1_batf_human RummaGEO Gene Perturbation Signatures 1.0 null FAM171A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01485 GTEX-TSE9-0011-R5A-SM-3DB7J GTEx Tissue Sample Gene Expression Profiles 1.0 0.978959 BDCA4+_DentriticCells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.29094 Retrosplenial area, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12182 GSE68156_0_v_1_dextran_mouse RummaGEO Drug Perturbation Signatures 1.0 null molecular_function GO Molecular Function Annotations 2015 1.0 null Long QT syndrome 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.215 BT483 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.764504 superficial stratum of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.41423 GTEX-QMR6-0011-R6A-SM-32PKP GTEx Tissue Sample Gene Expression Profiles 1.0 0.959479 Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EL-01A-12R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNRPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.3201 LOVO Achilles Cell Line Gene Essentiality Profiles 1.0 1.88913 Perturb_14971_KD_Crebbp_SRP154933 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.82093 Catalytic step 2 spliceosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.739 ZNF384 ENCODE Transcription Factor Targets 1.0 null ZDHHC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.96565 Zfp961 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 48.7927 H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null FEV CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.11824 H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U3ZM-0008-SM-4DXTQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24257 phosphorylation GO Biological Process Annotations 2015 1.0 null GSE126777_0_v_1_otub1_mouse RummaGEO Gene Perturbation Signatures -1.0 null EGR1 ChEA Transcription Factor Targets 1.0 null GC-46-AX49_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.208197 SHCBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66041 AXIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64663 single-organism metabolic process GO Biological Process Annotations 2015 1.0 null LRRC8E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01453 UMUC1 DepMap CRISPR Gene Dependency 1.0 4.90704 prepontine hindbrain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14872 CTCF_fibroblast of foreskin _hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4P3-0008-SM-3NM8R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46392 AVL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15831 ZNF217 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66657 Perturb_6890_KD_E2F1_SRP238361 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -13.8084 fallopian tube HPA Tissue Gene Expression Profiles 1.0 1.25651 ion transport GO Biological Process Annotations 2015 1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Urinary bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 OC-10-FB51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.217903 GSE240030,GSE252532_0_v_2_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE222758_0_v_3_clofazimine_human RummaGEO Drug Perturbation Signatures -1.0 null Elbow dbGAP Gene-Trait Associations 1.0 0.30965 GTEX-SJXC-0008-SM-4DM7G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.901346 GSE228106_3_v_5_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X585-0011-R3B-SM-46MVG GTEx Tissue Sample Gene Expression Profiles 1.0 1.47092 NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.828706 XRCC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60602 Juxtaparanode region of axon COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.74 Agenesis of the corpus callosum with peripheral neuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.048 HTRA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.507 GTEX-WZTO-0011-R1B-SM-3NMAR GTEx Tissue Sample Gene Expression Profiles 1.0 1.55033 HCC1806 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.958885 heart muscle HPA Tissue Protein Expression Profiles -1.0 -1.86909 central part of CEl Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12713 MLLT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.09952 ChIP_POU5F1_16518401 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-OIZH-1826-SM-2YUNP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78351 KM-12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.5739 PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null DUXB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27097 ETV4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22415 RCC10RGB CCLE Cell Line Gene CNV Profiles 1.0 1.39484 IL17C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13817 GSE150072,GSE169209_4_v_11_qser1_human RummaGEO Gene Perturbation Signatures 1.0 null RING1B-27294783-CHIP-SEQ-NPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-g-Classification_of_camel_SON_basal_genes_-_ion_channels_SON Rummagene Transcription Factor Associations 2026 1.0 null Retrosplenial area, lateral agranular part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46257 SLC25A30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89666 GSE168401_1_v_0_harmine_human RummaGEO Drug Perturbation Signatures 1.0 null STRADB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29668 XBP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1665 496100641_PCx_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.0329 CHD7 ENCODE Transcription Factor Targets 1.0 null SURF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59397 GSE68156_3_v_5_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null MDAMB468 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.978489 H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null substantianigra BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.21912 disease GWASdb SNP-Disease Associations 1.0 0.025308 GSE142430_3_v_0_prmt5_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-PLZ6-1326-SM-3NB24 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69649 CAKI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.856475 MED20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99742 biological regulation GO Biological Process Annotations 2015 1.0 null CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCL3 ENCODE Transcription Factor Targets 1.0 null SUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43833 GSE234340_10_v_7_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null DIP2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09531 H3K27me3_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary somatosensory area, lower limb, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59513 GTEX-P4QR-0008-SM-48TE2 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 GB-57-XV52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.477852 SK-N-AS cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.721 PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.21983 GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles 1.0 0.910436 EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.448511 EGR1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBLL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18505 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null p2 portion of the substantia nigra pars reticulata Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13113 TMEM131 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17539 MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r2 part of nucleus subcoeruleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0489 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null UBA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75001 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X4XX-0011-R10B-SM-46MWO GTEx Tissue Sample Gene Expression Profiles 1.0 1.45753 GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles 1.0 0.924822 HDDC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82003 Orbital area, lateral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11623 PAWR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13426 result GeneRIF Biological Term Annotations 1.0 null Sarcoma_SARC_TCGA-MO-A47R-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDCA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50633 extrinsic component of cytoplasmic side of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.463198 H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null potassium channel activity GO Molecular Function Annotations 2025 1.0 null CCNC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63023 GTEX-R55E-0011-R4A-SM-2TC5H GTEx Tissue Sample Gene Expression Profiles 1.0 1.363 BACH1 ENCODE Transcription Factor Targets 1.0 null salivary gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.117885 GSE173201_2_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.880154 EP300_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KNS-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.983093 POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3158-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.075559 GTEX-U3ZN-0008-SM-4DXTL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00462 KLF10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 111.156 GSE143743_0_v_2_c9orf72_human RummaGEO Gene Perturbation Signatures 1.0 null GSE210580_4_v_7_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE215086_1_v_6_batf_human RummaGEO Gene Perturbation Signatures -1.0 null medial pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43442 H2BC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49386 mantle zone of r2Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01717 RELA JASPAR Predicted Transcription Factor Targets 1.0 null GSE186287_2_v_3_ufm1_human RummaGEO Gene Perturbation Signatures -1.0 null ZFX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86602 H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null regulation of ion transmembrane transport GO Biological Process Annotations 2015 1.0 null CNPY3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42252 GTEX-T5JC-2526-SM-4DM6G GTEx Tissue Sample Gene Expression Profiles 1.0 0.966579 Kidney Chromophobe_KICH_TCGA-KN-8428-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCoV-EMC2012_7Hour_23631916_GSE45042 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.38852 HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07826 H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CBX2 ENCODE Transcription Factor Targets 1.0 null TFAP4::ETV1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.5355 lateral part of the lateral habenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02622 ZNF224 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62402 LN382 CCLE Cell Line Gene Expression Profiles 1.0 1.44864 MESSA CCLE Cell Line Gene Expression Profiles 1.0 1.73476 KNS42 DepMap CRISPR Gene Dependency 1.0 3.65093 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D6-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DCAF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70951 BC-01-JL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.361179 IRF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40249 ZNF708 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.0212 Perturb_15462_KD_FOXA1_SRP353748 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.79203 superficial stratum of cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18317 TAF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48784 CLN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.9646 Skin Cutaneous Melanoma_SKCM_TCGA-FW-A5DY-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null temporal lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.619814 H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BCL3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATXN1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82167 H3K27me3_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 posteromedial visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88837 SKRC20 CCLE Cell Line Gene Expression Profiles 1.0 1.38971 NCIH1385 CCLE Cell Line Gene Expression Profiles 1.0 2.22201 H3-4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56062 MARK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26855 TAF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33434 LCN12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03545 SLU7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10788 H3K27me3_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE126345_9_v_10_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null cytoplasmic side of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.463198 H3K27me3_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IM-95 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.960654 GTEX-TSE9-0226-SM-3DB84 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16813 GTEX-Q2AG-0011-R3A-SM-2HMJ9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.57565 Perturb_4200_KD_Mecp2_SRP072951 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GSE94814_1_v_0_reck_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null integral component of membrane GO Cellular Component Annotations 2015 1.0 null sub-surface cisterna COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.863 GSE169263_1_v_0_armc5_mouse RummaGEO Gene Perturbation Signatures 1.0 null NF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70707 GSE77108_4_v_9_saha_human RummaGEO Drug Perturbation Signatures -1.0 null DCTN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.999 r10 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38508 MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.68046 EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1 MotifMap Predicted Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-NJ-A55A-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE196117_1_v_5_clarithromycin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-QEG5-0326-SM-2S1PB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46211 TUHR10TKB CCLE Cell Line Gene Expression Profiles -1.0 -1.58354 GSE142210_2_v_5_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WHSE-0011-R6A-SM-3P5ZP GTEx Tissue Sample Gene Expression Profiles 1.0 1.23897 esophagus HPA Tissue Gene Expression Profiles -1.0 -1.54502 CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null U2AF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91895 EIF5A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90811 VLDLR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44011 GTEX-QEL4-0526-SM-3GIJ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.30153 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-8258-11A-01R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Vestibular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.216 amygdaloid complex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.03105 SOX9 ChEA Transcription Factor Targets 1.0 null H3K4me1_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PWN1-1626-SM-2S1OL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00376 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SEC16A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97598 GTEX-WHSE-1126-SM-3NMBU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.885582 RH30 DepMap CRISPR Gene Dependency 1.0 2.40662 Perturb_14596_OE_UQCRC1_SRP177975 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.15206 GSE134375_0_v_2_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_14265_KO_E2f2_SRP090185 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.49722 Hypolemmal cisterna COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.856 FF-28-ES17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.678738 GSE217552_3_v_2_fisetin_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TUBB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38174 GATA2 ENCODE Transcription Factor Targets 1.0 null GTEX-WL46-0011-R3A-SM-3TW8E GTEx Tissue Sample Gene Expression Profiles 1.0 1.91285 duodenum HPA Tissue Protein Expression Profiles 1.0 0.882435 abnormal seizure response to pharmacological agent MPO Gene-Phenotype Associations 1.0 null H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null PGK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77099 CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NBEAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55452 UBR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09696 inferior nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.9332 CHD1 ENCODE Transcription Factor Targets 1.0 null PMC12211354-12915_2025_2224_MOESM6_ESM.xlsx-Sheet1-Sheet1_The_source_list_of_zebrafish_Npas4b_targets_from_human_NPAS4_targets_in_CHEA3_database_NPAS4 Rummagene Transcription Factor Associations 2026 1.0 null Autosomal dominant nonsyndromic deafness DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.018 voltage-gated potassium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.763 PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null RAD21 ENCODE Transcription Factor Targets 1.0 null GSE206270_2_v_0_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null WTIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52916 PMC9232687-13238_2021_887_MOESM3_ESM.xlsx-37_KD_sgCDC20_vs_sgNTC-Differentially_expressed_genes_DEGs_upon_CDC20_knockdown_under_37_culture_AR Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LD-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FD-20-OG99_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.214525 LB771HNC DepMap CRISPR Gene Dependency 1.0 3.15648 hsa-miR-3921 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 periaqueductal gray substance, dorsolateral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.83472 GALNT11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8805 KIF3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85789 COPS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16649 liver HPA Tissue Protein Expression Profiles -1.0 -1.86909 posteromedial visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.73459 neuroblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.18472 GTEX-PSDG-1626-SM-48TCQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70935 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Lung adenocarcinoma_LUAD_TCGA-44-6147-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MM253 DepMap CRISPR Gene Dependency 1.0 2.34497 GSE111102,GSE111105_8_v_0_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null ED-05-LQ40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.22531 HMGN3 ENCODE Transcription Factor Targets 1.0 null abnormal retina morphology IMPC Knockout Mouse Phenotypes 1.0 null CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A7ER-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMCO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70044 ACOT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52265 GTEX-OOBJ-0008-SM-3NB26 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28932 Cs+ Guide to Pharmacology Chemical Ligands of Receptors 1.0 null USF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AG-0011-R7A-SM-2HMJP GTEx Tissue Sample Gene Expression Profiles 1.0 0.963289 PMC10204296-13578_2023_1034_MOESM16_ESM.xlsx-Black-ZNF671_ZNF671 Rummagene Transcription Factor Associations 2026 1.0 null hippocampus (hippocampal formation)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.894297 GTEX-QV44-0008-SM-447AX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0961 Perturb_8047_KD_MCRS1_SRP103083 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.24217 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormal long term potentiation MPO Gene-Phenotype Associations 1.0 null KDM2B-26808549-CHIP-SEQ-JURKAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null abnormal seizure response to inducing agent MPO Gene-Phenotype Associations 1.0 null astrocytoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.184128 KP2 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.32897 H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.61982 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38799