association dataset threshold value standardized value MAFF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60559 Sarcoma_SARC_TCGA-SG-A6Z7-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8110-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE102467_3_v_0_pazopanib_human RummaGEO Drug Perturbation Signatures -1.0 null Syncytiotrophoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.054 CRCGN017_MCF10A.TP53.M_24H:P11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.40022 KNS42 CCLE Cell Line Gene CNV Profiles 1.0 1.57922 VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.970115 FOSL1 ENCODE Transcription Factor Targets 1.0 null Nr2e3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.0 H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sox17 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 75.9066 IGROV1 CCLE Cell Line Gene Expression Profiles -1.0 -1.51138 rostral group of intralaminar nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.49063 ZNF543 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.43003 PIK3R4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99065 laminin-10 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.502 EFNB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45684 all GWASdb SNP-Phenotype Associations 1.0 0.028716 ADAT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69398 CC-68-YZ44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.200329 lateral tuberal nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.928882 SIRT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73248 MYC-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null OCILY19 CCLE Cell Line Gene CNV Profiles -1.0 -1.88991 arteriosclerosis GWASdb SNP-Disease Associations 1.0 0.390224 Sarcoma_SARC_TCGA-SI-A71Q-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.960048 MTARC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92453 NUGC-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null LCTL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49616 CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ebf4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.45 CRCGN016_MCF10A.TP53.M_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.16443 IZ in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.926827 TCL1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26253 bonemarrow BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.959223 cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.5354 MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNAI3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.567 MED16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89232 chromosome, subtelomeric region COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.581 JUND ENCODE Transcription Factor Targets 1.0 null SCAF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24783 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.09758 primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.29504 GSE216043_7_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.650811 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4811-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NHLH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48031 OCI-M2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13478 IMR-32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13657 Prostate adenocarcinoma_PRAD_TCGA-EJ-5514-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67V-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PEA15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67979 GSE206729_5_v_1_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.75767 FC-20-EQ58_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.243836 USF2 ENCODE Transcription Factor Targets 1.0 null ADM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.78994 ERI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15483 central medullary reticular group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.22226 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A461-01A-41R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PWWP2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60301 Foxf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.8144 CAOV3 DepMap CRISPR Gene Dependency 1.0 6.8505 Sox1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 43.7408 POM121 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20954 Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN013_HEPG2_24H:B13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.23624 midbrain reticular formation, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.91053 DDX60 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98238 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63U-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC5446900-NIHMS72240-supplement-Table_S1.xlsx-Table_S1-Table_S1_Genes_differentially_expressed_in_human_primary_myoblasts_upon_ectopic_expression_of_DUX4_DUX4 Rummagene Transcription Factor Associations 2026 1.0 null eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null outer SZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.87959 NCI-H2795 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54252 TSHZ3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83656 PITX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.5609 laterorostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.70148 arterial stenosis GWASdb SNP-Phenotype Associations 1.0 0.245752 Lung adenocarcinoma_LUAD_TCGA-86-8585-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ERBB2_druginhibition_7_GDS2139 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.04731 Primary hematopoietic stem cells G-CSF-mobilized Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.6335 RARA_KD_GDS4065_42_human_MCF-7 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null LMSU DepMap CRISPR Gene Dependency 1.0 2.2948 Rhabdomyosarcoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.165 Yersinia enterocolitica food poisoning_Peyer's patch_GSE4764 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.51712 T47D DepMap CRISPR Gene Dependency 1.0 2.27169 GABRB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52313 EPCAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40051 FOXQ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87314 NCIH1792 CCLE Cell Line Gene Expression Profiles 1.0 1.54281 Six4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 42.639 SNAI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.20115 FBXO7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67931 RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13214 LRRC58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94224 Trophoblast stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.662 BCL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49914 Adrenocortical carcinoma_ACC_TCGA-OR-A5J3-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN012_HEPG2_24H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.13729 frontal pole, right, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.21492 cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.109267 CRCGN008_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9988 NKX2-5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4855 BHLHA15 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.585 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.937808 Mosaic variegated aneuploidy syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.218 PCDHB12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08163 Primary hematopoietic stem cells G-CSF-mobilized Female RO_01480 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.4977 CHRNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8056 Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549 DepMap CRISPR Gene Dependency 1.0 2.80591 KRBOX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61593 Adrenocortical carcinoma_ACC_TCGA-OR-A5KZ-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92284 GDF15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33704 Muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.475 M059K CCLE Cell Line Gene CNV Profiles 1.0 1.38665 Primitive endoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.336 YARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09631 SNU475 DepMap CRISPR Gene Dependency 1.0 2.09321 A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.937808 Bach1::Mafk JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 53.9912 TE15 CCLE Cell Line Gene Expression Profiles 1.0 2.64746 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW1463 COSMIC Cell Line Gene Mutation Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CL11 CCLE Cell Line Gene Expression Profiles -1.0 -1.84222 Nr5a2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 83.3662 FOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 257.393 Kidney Chromophobe_KICH_TCGA-KN-8429-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HZ-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CE-24-LQ98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.348493 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prdm14 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.2173 PUS7L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8546 GSE216043_10_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-7222-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.81983 ZBTB7B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06517 hsa-miR-4279 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null C32 DepMap CRISPR Gene Dependency 1.0 3.00746 AC-35-CK01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.40992 ZMPSTE24_Deficiency_GDS3775_506_mouse_Embryonic fibroblasts GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null ARHGEF40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86122 L-540 COSMIC Cell Line Gene Mutation Profiles 1.0 null mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.933966 COLO 678 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.911826 Oral cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.809 COPS7B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49322 LN18 BioGPS Cell Line Gene Expression Profiles -1.0 -0.909909 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.60599 TCF15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74304 GSE216043_11_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN009_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.74175 OVSAHO CCLE Cell Line Gene CNV Profiles 1.0 1.8138 NCIH23 DepMap CRISPR Gene Dependency 1.0 2.74634 CRCGN012_HEPG2_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.07426 Liver hepatocellular carcinoma_LIHC_TCGA-GJ-A6C0-01A-12R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:L02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.45923 GSE174498,GSE174500_5_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null EGR1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HSF1_KD_GDS1733_750_human_HeLa cells - 0 Hour GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ATN-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE172494_3_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2450 DepMap CRISPR Gene Dependency 1.0 3.02022 motor nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.941311 MV-4-11 COSMIC Cell Line Gene Mutation Profiles 1.0 null Morula TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.374 X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33558 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Process Annotations 2023 1.0 null outer SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07871 M140325 DepMap CRISPR Gene Dependency 1.0 13.0837 Rectum adenocarcinoma_READ_TCGA-AF-2687-01A-02R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE240386,GSE242143_1_v_5_morc2_human RummaGEO Gene Perturbation Signatures -1.0 null RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH2452 DepMap CRISPR Gene Dependency 1.0 2.15067 MDA-MB-435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.84393 USF2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JURKAT COSMIC Cell Line Gene Mutation Profiles 1.0 null IRF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.4167 TYKNU CCLE Cell Line Gene CNV Profiles -1.0 -2.14796 SHOX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.8352 mediodorsal nucleus of thalamus_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.11246 H3K27ac_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN015_HEPG2_48H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.8563 GSE107956,GSE107957_0_v_1_ythdf2_human RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A4TM-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.TP53.M_24H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.81558 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.9168 JA-88-IO52_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20702 FOSL1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Erg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 47.9911 SKN-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null KYSE510 CCLE Cell Line Gene Expression Profiles 1.0 1.41136 KDM5B ENCODE Transcription Factor Targets 1.0 null U2AF1L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06644 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.0062 Germ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.394 SuperiorCervicalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.84458 Dinoflagellate cingulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.51 CRCGN010_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.27536 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5185-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormalities of the peripheral arteries GWASdb SNP-Phenotype Associations 1.0 0.245752 ZSCAN10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31775 Iliopsoas muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.859 primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.70411 Liver hepatocellular carcinoma_LIHC_TCGA-BW-A5NO-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC48A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21165 SFRP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52761 Stat6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 73.2948 C2orf68 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9282 OLFML2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90726 Adrenocortical carcinoma_ACC_TCGA-OR-A5JL-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM20C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87551 NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.883326 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 YKG-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null FGF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45021 MZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.896513 gracile nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.952505 mRNA_SFPI1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE212330_1_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null BT474 CCLE Cell Line Gene Expression Profiles -1.0 -1.45567 PPT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92715 hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.15966 CRCGN017_MCF10A.WT.HP_24H:O15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.12595 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3YS-01A-11R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UHRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28941 CRCGN015_HEPG2_48H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.37755 ventral tegmental area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08021 CRCGN008_HEPG2_24H:A04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4886 AE-39-DG66_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.231575 RBBP5 ENCODE Transcription Factor Targets 1.0 null AICD_Induced expression / Over-expression_GDS1979_288_human_SHEP-SF neuroblastoma GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null muscle tissue disease GWASdb SNP-Disease Associations 1.0 0.235725 ARID3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAPK8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19544 GSE162892_4_v_0_isox_human RummaGEO Drug Perturbation Signatures -1.0 null TAPBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29185 HDAC2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_24H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.0605 Ebf2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 37.9308 GSE226355,GSE226357_3_v_4_ybx1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE115542_5_v_3_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MFSD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34197 precentral gyrus, right, inferior lateral aspect of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.96571 cerebellar cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.0037 BNC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6382 PIAS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78495 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4759-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SBC5 CCLE Cell Line Gene CNV Profiles 1.0 1.58832 496100446_TCx_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.27563 EBF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92505 ZFTA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7907 coronary artery disease GWASdb SNP-Disease Associations 1.0 0.811614 A-498 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11207 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.53262 H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A61B-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN010_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8043 ZNF320 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88534 Extraembryonic tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.92 Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5843-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100408_PCx_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.38112 CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.36027 SETDB1 ENCODE Transcription Factor Targets 1.0 null ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JB-23-ZE86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208093 Brain Lower Grade Glioma_LGG_TCGA-IK-7675-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Coats disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.413 Germ cell and embryonal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.063 FF-06-MO73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.251221 OC-10-FB51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.341262 CRCGN008_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.50355 Zfp961 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.5973 KPL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.62966 NGFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52199 GSE168401_2_v_0_harmine_human RummaGEO Drug Perturbation Signatures -1.0 null NEUROG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18125 UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.9267 Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.9368 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SHOX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02157 TTLL8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47942 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4923-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amygdaloid complex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.913441 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.842485 Stat2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 253.718 APPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87836 Zbtb2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.8116 SG in posterior frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11654 ZNF880 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38289 H3K27me3_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LTBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38235 TRIM24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7488 IZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03433 musculoskeletal system disease GWASdb SNP-Disease Associations 1.0 0.078144 head of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.27684 COLO680N CCLE Cell Line Gene Expression Profiles 1.0 2.20356 Huntington's Disease_CNS - Brain (MMHCC)_GSE857 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.03646 NEC8 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.75637 Lung squamous cell carcinoma_LUSC_TCGA-85-8071-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.95861 BATF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94435 HOXC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50774 ETV3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61466 motor nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.975488 NB14 COSMIC Cell Line Gene Mutation Profiles 1.0 null temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.58498 Liver GTEx Tissue Gene Expression Profiles 2023 1.0 3.32941 Wt1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 69.3547 PRDM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17615 Zfp335 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.3333 EE-03-SG02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.245191 RPL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90445 HE-84-SC79_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.228393 NFIB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.1164 SPTBN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20678 ZNF257 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 52.4503 ADO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50603 CHLA90 DepMap CRISPR Gene Dependency 1.0 2.28532 VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.16587 MAFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19648 Muscle tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.539 GSE206516,GSE206518_2_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23034 DNAL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17391 PE01 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15317 Prostate adenocarcinoma_PRAD_TCGA-EJ-A65B-01A-12R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.93825 JEKO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.34204 GORAB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04719 mRNA_ID1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null SETDB1 ChEA Transcription Factor Targets 1.0 null TRPM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62733 primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.08004 Lung adenocarcinoma_LUAD_TCGA-55-8094-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SETDB1-19884257-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GSE212330_1_v_0_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EBF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTRL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56373 CYB5D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96507 HDAC2 ENCODE Transcription Factor Targets 1.0 null HCC-33 COSMIC Cell Line Gene Mutation Profiles 1.0 null chr6_73252693_T_C_b38 GTEx eQTL 2025 1.0 1.01789 Crx JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.4189 MRPL30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55379 ES8 DepMap CRISPR Gene Dependency 1.0 5.46376 P300-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Dlx5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.6821 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4707-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null basal ventral medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.845803 SHMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.235 hsa-miR-588 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 CRCGN014_HEPG2_24H:F17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.13286 MTHFD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89327 TSC1_Deficiency_GDS4572_347_mouse_Naive CD8 T cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CRCGN009_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.33051 COL7A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50099 GE-53-SM76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.487355 AA-18-GQ83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.419186 subcuneiform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.992406 mRNA_AES_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null AD-16-HL96_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.239514 Arid3b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 42.415 FZD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77944 TCF7L2_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFYB ENCODE Transcription Factor Targets 1.0 null tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 TBL1XR1 ENCODE Transcription Factor Targets 1.0 null Hmx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 40.6458 artery disease GWASdb SNP-Disease Associations 1.0 0.204419 AGPAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.371 Nfatc2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.8262 YY1 ENCODE Transcription Factor Targets 1.0 null MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.905638 CP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17184 EZH2_DEPLETION_GDS2445_117_human_embryonic fibroblasts GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.830662 SRY JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.6429 Teratoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.114 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5187-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hippocampus (hippocampal formation)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.37622 NPM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65517 Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5561-01A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Myotube TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.426 inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.98518 Lung squamous cell carcinoma_LUSC_TCGA-37-5819-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Tongue cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.948 ATF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30312 IKBKG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70684 SG in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.87516 H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Vdr JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 42.4975 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4074-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2810-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KIAA0930 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83791 CRCGN014_HEPG2_24H:J15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.66595 CCF-STTG1 COSMIC Cell Line Gene Mutation Profiles 1.0 null PI4KA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26115 EC-62-OE64_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.236822 OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19488 Kidney Chromophobe_KICH_TCGA-KM-8438-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.13173 F8A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.9238 BORCS7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5594 CRCGN015_HEPG2_48H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.53574 MUS81 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13617 Mesothelioma_MESO_TCGA-SC-A6LM-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K36me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null OCT4-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NEFM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11093 TPRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19783 DEK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73116 H3K4me1_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Tibialis posterior TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.858 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5092-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PD-70-VS77_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.232639 ECSIT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89838 TAP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.73 NFE2L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44222 FBXO27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90672 FAM193A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1702 RPMI8226 CCLE Cell Line Gene CNV Profiles 1.0 2.02825 EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.23094 precentral gyrus, right, bank of the precentral sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18492 hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.26563 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE229973_3_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null MAX_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ERG28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66298 Rectal Mucosa Donor 31 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.90872 USH1G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34581 Dux JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 58.3701 MOS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22298 body of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.08048 TEX19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19889 EMD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79507 CAPAN1 DepMap CRISPR Gene Dependency 1.0 3.09526 KYSE-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07222 CRCGN009_HEPG2_24H:F19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1113 ZNF691 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42096 Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5SP-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Rectum adenocarcinoma_READ_TCGA-EI-6513-01A-21R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF268 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97707 RTL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.20041 GSE130246_2_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null MEF2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3512 DMRTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33114 SH4 CCLE Cell Line Gene CNV Profiles -1.0 -2.02363 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ESR1 JASPAR Predicted Transcription Factor Targets 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q7-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUS-01A-12R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TestisLeydigCell BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.909495 FOSL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null COGN305 DepMap CRISPR Gene Dependency 1.0 2.1313 GSE238116_3_v_2_egr1_human RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sox11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 166.045 WC-16-IR43_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.351209 HCC38 CCLE Cell Line Gene Expression Profiles 1.0 1.57507 mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.09956 NB7 DepMap CRISPR Gene Dependency 1.0 3.34961 MOR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.32011 G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.937808 primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.985001 GSE216043_10_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null RAB34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54239 IRF6_01_101 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.40069 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Nearest_Ensembl_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null PMVK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92211 EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-6761-01A-31R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2BC7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61778 dorsal cochlear nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.654 coronary artery disease GWASdb SNP-Phenotype Associations 1.0 0.707523 CRCGN014_HEPG2_3H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.68717 496100364_TCx_possible Alzheimer's disease_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.88284 MYO19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40012 A253 CCLE Cell Line Gene Expression Profiles 1.0 3.40818 OSBPL11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65349 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A7Q1-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_3H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0485 NPIPA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68293 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HT-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:L01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.23658 LRRC34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56517 GSE182921_0_v_1_slit2_human RummaGEO Gene Perturbation Signatures 1.0 null HSFX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47124 KAT6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59639 Skin BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.09491 CDK5R1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48425 FOS ENCODE Transcription Factor Targets 1.0 null PANC0213 CCLE Cell Line Gene CNV Profiles -1.0 -1.38618 SETD1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35411 Bcl11b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 115.215 TERT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31731 Facioscapulohumeral muscular dystrophy 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.642 KASUMI-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null DMS153 CCLE Cell Line Gene CNV Profiles 1.0 1.33404 Trophectoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.984 CRCGN016_MCF10A.WT.HP_24H:E19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.13681 primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.6076 FA-36-VA24_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.762625 ENDOG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5815 H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_17480_KO_IGF2BP1_SRP277076 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Adrenocortical carcinoma_ACC_TCGA-PK-A5HB-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Rd TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.387 DCBLD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02665 EBF1 ENCODE Transcription Factor Targets 1.0 null PMC12909843-41467_2026_68388_MOESM4_ESM.xlsx-fig3g-up-regulated_gene_expression_in_OTX2-KO_8CLCs_OTX2 Rummagene Transcription Factor Associations 2026 1.0 null ZSCAN21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72328 body of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.80489 CE-96-GH46_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.249837 superior olivary complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.833721 EP300_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPARGC1A_NULL MUTATION_GDS2149_721_mouse_Brown adipocyte GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null NPTXR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2339 SYP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91323 FOSL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4131 PAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.0377 NPM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48386 SCC9 CCLE Cell Line Gene Expression Profiles 1.0 1.49143 MYT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29119 RALBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53416 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.974329 JUN_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1509 JUN_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pontine raphe nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.826791 Brain Lower Grade Glioma_LGG_TCGA-S9-A7QZ-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inner CP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07261 BICR6 CCLE Cell Line Gene Expression Profiles 1.0 1.97695 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4813-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null INTS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0479 KCIMOH1 DepMap CRISPR Gene Dependency 1.0 4.478 PMC10870497-13046_2024_2976_MOESM10_ESM.pdf-14-EBF4_EBF4 Rummagene Transcription Factor Associations 2026 1.0 null RCCD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12788 MFHAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46759 mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.17173 VZ in septal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17084 BE-27-RQ61_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.223689 TRNT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88178 chr6_73249384_C_T_b38 GTEx eQTL 2025 1.0 1.26385 oocyte BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.48222 ATRX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56027 ATF3 ENCODE Transcription Factor Targets 1.0 null CAL62 CCLE Cell Line Gene CNV Profiles 1.0 1.38969 Mature teratoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.767 IZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.26457 FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FC-55-IG96_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.225524 COX7A2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90685 KLE CCLE Cell Line Gene Expression Profiles 1.0 1.78697 TAL1_megakaryocyte_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT-483 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.43254 ventral tegmental area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1602 outer CP in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.826894 CE-96-GH46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.462187 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN012_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.93225 HdhQ111/111_Knock-in_GDS4534_744_mouse_Striatum and cerebellum GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null DICER1_KO_GDS4504_582_mouse_bone marrow granulocyte-macrophage progenitors GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null 496100521_HIP_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.18583 496100429_TCx_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.39071 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.937808 FHIP1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46976 midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.59391 UBR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09696 GSE229973_3_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null MZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.840779 Dlx2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.396 BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS 940.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.72037 HIVEP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62972 MEF2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 76.8244 NCIH2110 CCLE Cell Line Gene Expression Profiles 1.0 2.41136 NCI-H1155 COSMIC Cell Line Gene Mutation Profiles 1.0 null orbital frontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.20073 COLO-829 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_MCF-7_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8791933-41598_2022_4817_MOESM3_ESM.xlsx-DUX4_signature_genes-Unnamed_2_DUX4 Rummagene Transcription Factor Associations 2026 1.0 null LHX8_Deficiency_GDS3254_600_mouse_Newborn ovaries GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.21046 COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39884 Hmga1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 43.0088 primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.4951 MYOD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.5726 SIX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.7856 Irf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 63.5703 PMC11216401-Supplemental_figures.pdf-11-KLF17_KLF17 Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-A4X9-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTPS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22318 YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIM68 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10868 MSH4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73552 GSE172458_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AP3M2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45016 CA4 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.828978 Acute Myeloid Leukemia_LAML_TCGA-AB-2849-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE216043_11_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null JUN_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hoxd13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 47.1886 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.02874 PMC8791933-41598_2022_4817_MOESM3_ESM.xlsx-DUX4_signature_genes-Unnamed_1_DUX4 Rummagene Transcription Factor Associations 2026 1.0 null QA-58-CX23_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.233842 CAMA1 CCLE Cell Line Gene CNV Profiles -1.0 -1.55088 CRCGN014_HEPG2_3H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8778 POGLUT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26761 SLC35D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22101 PL-21 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.933152 AK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.956 H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A5TW-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bhlha15 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.3085 KMT5C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78098 primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.15162 Kidney renal clear cell carcinoma_KIRC_TCGA-MM-A84U-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsal subdivision of VLC Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.885539 mRNA_RHOX6_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null KLHL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87587 AP1G1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85879 ME-31-RM40_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.441222 PSMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70029 medial group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.928357 GSE147626_3_v_1_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null Gata3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.2823 MATCAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5208 NT5DC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94291 Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.5721 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.906491 A4FUK CCLE Cell Line Gene Expression Profiles 1.0 1.36564 ZMYND8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13481 EP300_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GPBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7969 SG in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.30863 A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_7day-MOI-10^4_None_GSE43301 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.10002 COV434 DepMap CRISPR Gene Dependency 1.0 4.02742 CFPAC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03109 EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.47607 RHOBTB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72479 primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.982508 NEIL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8532 GLYATL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60813 Adrenocortical carcinoma_ACC_TCGA-OR-A5J5-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FE-10-KQ78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.202987 TAL1 ENCODE Transcription Factor Targets 1.0 null H4C1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17355 IZ in rostral cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36471 striatum_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.45873 TWIST1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.3479 POMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42073 TMEM161A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81045 abnormality of the systemic arterial tree GWASdb SNP-Phenotype Associations 1.0 0.139727 PROX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.5855 OCI-LY-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.906491 Alx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.7791 TAL1::TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1591 SNU46 CCLE Cell Line Gene Expression Profiles 1.0 1.48715 H2AFZ ENCODE Transcription Factor Targets 1.0 null Zika virus congenital syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.541 Lhx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 44.7 ZNF792 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60296 V, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.940574 CRCGN016_MCF10A.TP53.M_24H:O15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.34433 MCF7 BioGPS Cell Line Gene Expression Profiles -1.0 -1.02215 Lung squamous cell carcinoma_LUSC_TCGA-60-2719-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Creb5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.6183 Stat5a::Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.0188 ERP44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23484 posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04189 ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.89558 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7II-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08256 Liver hepatocellular carcinoma_LIHC_TCGA-BC-4073-01B-02R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IGF2BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12623 PMC6639357-41467_2019_11150_MOESM4_ESM.xlsx-SupTab1_Activated_genes_diffex-Supplementary_Data_1_Fold_change_and_p-value_of_all_activated_protein_coding_genes_upon_DNMT1-KO_DNMT1 Rummagene Transcription Factor Associations 2026 1.0 null CBX3_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1 ENCODE Transcription Factor Targets 1.0 null hsa-miR-3664-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.901392 Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OVKATE CCLE Cell Line Gene CNV Profiles -1.0 -1.51349 Mafb JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.6934 STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCNB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93669 GLRX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98101 disease GWASdb SNP-Disease Associations 1.0 0.032338 dorsolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.52095 HCC202 CCLE Cell Line Gene CNV Profiles -1.0 -2.45339 oculomotor nuclear complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.47396 SCC4 CCLE Cell Line Gene Expression Profiles 1.0 2.1788 IRAK2_knockout_39_GSE10765 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.61561 PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SG in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.44104 GSE74251_0_v_3_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-WY-A85C-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GA-28-SS67_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.211915 striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.92915 OVCAR8 CCLE Cell Line Gene CNV Profiles 1.0 1.5003 ERBB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02293 HADH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36372 GSE74251_2_v_1_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GALNT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84871 Zic2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.0981 H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26702 Mafg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 37.3115 FOXD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 61.5414 D-502MG COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8424-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nfe2l2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 49.9311 PROCR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16111 VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.08842 HOXB9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5973 Hmx2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 89.6771 H9 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.143 MESSA CCLE Cell Line Gene CNV Profiles -1.0 -1.7386 SKLU1 CCLE Cell Line Gene CNV Profiles -1.0 -1.36688 CRCGN012_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.9245 CRCGN017_MCF10A.TP53.M_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.90922 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4770-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Arid3a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 60.0741 ITGB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9817 WSB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42476 intercalated nucleus of medulla Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.53669 Tbx6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 43.2874 Pax7 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 39.5543 RAJI CCLE Cell Line Gene CNV Profiles 1.0 2.89984 Prdm5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 40.177 Atoh1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 40.1395 TC32 DepMap CRISPR Gene Dependency 1.0 6.50231 Nkx3-2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.2281 cuneate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.926609 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mRNA_DNMT3B_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A905-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AC18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25071 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of the vasculature GWASdb SNP-Phenotype Associations 1.0 0.100017 EM2 CCLE Cell Line Gene CNV Profiles 1.0 1.95284 CRCGN014_HEPG2_3H:M21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5714 SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMC1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88292 CRCGN015_HEPG2_48H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.95206 DMRTC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.10364 KYSE410 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 CRCGN009_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.63457 central portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08536 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.19044 Primary hematopoietic stem cells G-CSF-mobilized Female RO_01549 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.47438 ASH1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98871 PAX5 ENCODE Transcription Factor Targets 1.0 null PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53 Rummagene Transcription Factor Associations 2026 1.0 null abnormality of the coronary arteries GWASdb SNP-Phenotype Associations 1.0 0.307902 0225151-0000-6389 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ADAM10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08641 JHH1 CCLE Cell Line Gene Expression Profiles 1.0 1.52769 VZ in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.867017 RNA binding GO Molecular Function Annotations 2023 1.0 null RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30485 LYSET CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16806 PREPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44561 posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.48476 NOMO-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null NCI-H1793 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15253 UBB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58903 STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE205163,GSE205164_9_v_0_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null GUSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42976 UBTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48919 AA-23-FM46_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.211336 GSE206729_3_v_1_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null STK31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2712 MEF2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.543 tail of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.16452 MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14393 amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.86708 CA1 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.16991 SH3BP5L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08912 COV504 CCLE Cell Line Gene Expression Profiles -1.0 -1.69668 FOSL1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEY DepMap CRISPR Gene Dependency 1.0 2.5147 inferior olivary complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.45003 LU99 CCLE Cell Line Gene CNV Profiles 1.0 1.39487 LAMA84 CCLE Cell Line Gene CNV Profiles 1.0 1.41636 EMILIN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85458 GSE173201_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2759-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TPRX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42388 mRNA_DPPA5A_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null SATB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.2291 ventral claustrum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18674 Rarg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 77.2106 H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ICAM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83792 CEBPB_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRMT2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.93359 BST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82319 Rarb JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 89.1018 abnormality of the cardiovascular system GWASdb SNP-Phenotype Associations 1.0 0.048492 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19379 CiliaryGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.28319 hsa-miR-4701-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 CRCGN013_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.15048 UBE2R2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36596 Ppara JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.5515 UBQLN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40729 TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PCM6 CCLE Cell Line Gene CNV Profiles -1.0 -1.82537 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-8693-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2IP-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JTB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21262 RSRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24679 REH COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN015_HEPG2_48H:L19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.65114 KDM5A ENCODE Transcription Factor Targets 1.0 null BCL6-25482012-CML-JURL-MK1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MYC ENCODE Transcription Factor Targets 1.0 null CRCGN014_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.7989 CP in rostral hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.40096 Brain Lower Grade Glioma_LGG_TCGA-HW-A5KJ-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE229973_3_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null RAD54L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9535 EGR1 ENCODE Transcription Factor Targets 1.0 null GSE239844_4_v_5_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.22022 CLK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98641 inferior occipital gyrus, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.12834 DNAJC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73808 HSC3 CCLE Cell Line Gene Expression Profiles 1.0 1.35205 T3M10 CCLE Cell Line Gene CNV Profiles -1.0 -1.37774 Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5EA-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA3 JASPAR Predicted Transcription Factor Targets 1.0 null H4 DepMap CRISPR Gene Dependency 1.0 4.39976 DND-41 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Nr5a1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 51.4143 CRCGN010_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.04335 NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.82626 ARHGAP23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97628 lower (caudal) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1954 CRCGN010_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06553 MTO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72943 CEP350 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95702 PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_PSc_vs_NB_2D_MSC Rummagene Transcription Factor Associations 2026 1.0 null MALME3M CCLE Cell Line Gene Expression Profiles -1.0 -2.66717 16651409-SuppTable5 GeneSigDB Published Gene Signatures 1.0 null SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.082 HELZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55233 Sox5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.9355 paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13968 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8003-01A-21R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DD-42-PC65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.240988 interstitial nucleus of Cajal, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.867636 CABIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01379 PDPK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70734 NIPA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68454 SF172 DepMap CRISPR Gene Dependency 1.0 2.58946 TYK-NU.CP-R Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.0512 Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EL-01A-12R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FF-86-NH56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.380765 SOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93629 Pheochromocytoma and Paraganglioma_PCPG_TCGA-PR-A5PF-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KOSC2 DepMap CRISPR Gene Dependency 1.0 2.54842 CERCAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31329 MDAMB231 CCLE Cell Line Gene CNV Profiles 1.0 1.50917 Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IJ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX::MYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.8095 BTG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54781 NPAS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45693 mRNA_ASCL2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null SLC30A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04316 DICER1_KO_GDS4504_584_mouse_bone marrow granulocyte-macrophage progenitors GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CRCGN012_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.85355 GB-46-CK08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.201433 PTPN23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45798 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BS-01A-21R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.933439 CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.443957 DDX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8463 UBTF ENCODE Transcription Factor Targets 1.0 null HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.9267 ZNF875 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08366 SMCR8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92235 WTAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.51871 MEF2D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.2707 hsa-miR-21 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EGR1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.6889 lung HPA Tissue Gene Expression Profiles 1.0 1.39437 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7915-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null F5 DepMap CRISPR Gene Dependency 1.0 6.08699 RKO COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN012_HEPG2_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01295 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.0605 NCI-H196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.898217 FKBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61221 H3K9me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Whole Blood GTEx Tissue Gene Expression Profiles 2023 1.0 2.81387 CASP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13087 anterior group of nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.967246 MAZ ENCODE Transcription Factor Targets 1.0 null TIGD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14338 head of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.08264 Lung squamous cell carcinoma_LUSC_TCGA-39-5011-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QF-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM47E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44114 THP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26702 GSE229973_3_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null ATF3-27146783-CHIP-SEQ-COLON-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CSNK1A1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80478 EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null striatum_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.04345 ZBTB7A ENCODE Transcription Factor Targets 1.0 null CAOV4 CCLE Cell Line Gene CNV Profiles -1.0 -1.64106 Semimembranosus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.608 FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF384 ENCODE Transcription Factor Targets 1.0 null GE-47-OO30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.382323 primary motor cortex (area M1, area 4)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03744 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7353-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IFI30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17322 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.84393 polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.72929 HCC2814 CCLE Cell Line Gene CNV Profiles 1.0 2.27552 ZNF384 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 386.976 striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.29283 EA-39-YN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.454114 Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47N-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBX18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.3097 496100547_HIP_no dementia_no TBI_82_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.29184 Shox2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.5652 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.829924 primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.29504 mRNA_MSC_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null RBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55584 REST_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE223908,GSE223909_4_v_8_serpinb3_human RummaGEO Gene Perturbation Signatures -1.0 null TGIF2LY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75684 outer CP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23217 SE-15-AV21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.346739 MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TJAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.14099 AG-013608-6440 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TAX1BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90643 H3K36me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null frontal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.890791 vascular disease GWASdb SNP-Disease Associations 1.0 0.154122 SNU324 CCLE Cell Line Gene CNV Profiles -1.0 -1.54576 SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.68401 molecular layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00423 pc3 HPA Cell Line Gene Expression Profiles 1.0 1.22434 SNU685 DepMap CRISPR Gene Dependency 1.0 2.35179 GALT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62708 GSE248874_1_v_0_pcdh9_human RummaGEO Gene Perturbation Signatures 1.0 null Hoxa13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 71.544 CRCGN015_MCF10A.TP53.M_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4768 17638894-Table2 GeneSigDB Published Gene Signatures 1.0 null HS852T DepMap CRISPR Gene Dependency 1.0 2.55912 POLR3G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7035 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.53983 CRCGN015_HEPG2_48H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.65929 IRF8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.9607 RWDD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79322 ISYNA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53232 LSR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39569 MFSD14B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.1538 Small Intestine - Terminal Ileum GTEx Tissue Gene Expression Profiles 2023 1.0 1.52502 NP5 DepMap CRISPR Gene Dependency 1.0 3.27417 SU-DHL-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10424 mRNA_NANOG_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null ZNF524 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2 XPNPEP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79944 CRCGN009_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.90304 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19185 HSPB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34596 Ar JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 79.9284 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4W-01A-12R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4849-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE145639_1_v_6_adar_human RummaGEO Gene Perturbation Signatures -1.0 null Cytotrophoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.2 WD-62-UB45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.231179 MRPS36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37929 Rhox11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.5036 Runx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.8035 Blastocyst TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.496 Stat4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 52.3087 TCF7L2 ENCODE Transcription Factor Targets 1.0 null choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.26664 WHSC1 ENCODE Transcription Factor Targets 1.0 null AN3 CA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00085 Retinal telangiectasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.913 primary motor cortex (area M1, area 4)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.45016 CBX3 ENCODE Transcription Factor Targets 1.0 null RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.73773 CRCGN015_HEPG2_48H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.6781 Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.04846 A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_7day-MOI-10^4_None_GSE44445 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.68383 TK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01105 GFOD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21385 VRK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22328 Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DM-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null E2F6 ENCODE Transcription Factor Targets 1.0 null HCC827GR5 CCLE Cell Line Gene Expression Profiles 1.0 1.67366 GSE162892_4_v_0_sox9_human RummaGEO Gene Perturbation Signatures -1.0 null myopathy GWASdb SNP-Disease Associations 1.0 0.811614 KLF13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.3726 hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.06618 CRCGN015_HEPG2_48H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.46837 Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A67D-01A-31R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU761 DepMap CRISPR Gene Dependency 1.0 2.18318 QF-71-QI30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.233834 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-5247-01A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-1229 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 WDR44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66119 CRCGN015_HEPG2_48H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.82965 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.914103 CRCGN015_HEPG2_48H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.04997 Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8S1-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ENTPD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26604 ROCK_INHIBITION_GDS3944_462_mouse_Forebrain astrocytes - 6 Hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null UO31 BioGPS Cell Line Gene Expression Profiles -1.0 -0.987104 A_CA_04_2009_4dayMOI-10^6_None_GSE37569 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.54736 Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.1221 NCIH650 CCLE Cell Line Gene Expression Profiles 1.0 1.86998 CRCGN009_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.59658 Internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXM1-26100407-CHIP-SEQ-HEK293-FLP-IN-HUMAN ChEA Transcription Factor Targets 2022 1.0 null rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2668 Ikzf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 58.705 OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.38664 FHDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83137 blastocysts BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07371 IRF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.3509 ACHN BioGPS Cell Line Gene Expression Profiles -1.0 -0.987104 Dlx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.0856 CRCGN014_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.65163 Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A623-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:F01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.7007 CPEB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32933 CRCGN015_HEPG2_48H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.82347 Decidual cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.802 parietal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.07717 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.863925 BBS7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79642 ventrolateral prefrontal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.02206 KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70O-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IFT57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11949 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Extravillous cytotrophoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.526 GSE206516,GSE206518_1_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null H4C16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93741 Lung squamous cell carcinoma_LUSC_TCGA-77-8148-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Germinal disc TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.521 ovary BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23083 PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Up_regulated_DEGs_of_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null HCC1599 CCLE Cell Line Gene Expression Profiles -1.0 -2.03309 NCO2 CCLE Cell Line Gene CNV Profiles 1.0 1.54165 HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.826459 H2BC21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77795 H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-1017-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Duodenum Mucosa Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.03442 PD-70-VS77_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.228226 ULK1_knockout_197_GSE60778 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.22538 DYNC2I1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55305 PASK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22601 GRAMD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66803 POLR2A ENCODE Transcription Factor Targets 1.0 null dexamethasone_homo sapiens_gpl6244_gse20963 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4730-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNAI2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.4954 lateral tuberal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12217 GSE210662_3_v_1_znf165_human RummaGEO Gene Perturbation Signatures 1.0 null GSE216043_7_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null basomedial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.21816 disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.041158 CRCGN014_HEPG2_24H:H18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.80117 PRR7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88194 C6orf226 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27733 CTCF_MCF-7_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null MOB3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56753 RAB3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58543 primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.42634 ARAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14169 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B5-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE206516,GSE206518_3_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null subgenual (subcallosal) division of MFC (area 25) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3734 M059J Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03388 SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.830662 TBC1D23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12959 PLEKHG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57965 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.50913 SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.81175 GNRH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79704 ECEL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.878 EC-62-OE64_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.23021 IRF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.0151 CE-18-AP15_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.242721 ASXL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.23051 IA-27-CK10_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.310633 CD-16-KY17_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.212176 GSE216043_11_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null KYM1 DepMap CRISPR Gene Dependency 1.0 2.61118 NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26702 X Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.15703 inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.29694 CTCF ENCODE Transcription Factor Targets 1.0 null PRDM8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32539 MZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02145 primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.27108 CRCGN009_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8278 HEC59 DepMap CRISPR Gene Dependency 1.0 2.29953 FOXO3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10733 NAA40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.71521 EE-03-SG02_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.295847 MYADM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19073 ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.942563 A-CA-04-2009(H1N1)_Day1_22532695_GSE36328 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.37747 atherosclerosis GWASdb SNP-Phenotype Associations 1.0 0.307902 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN010_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4443 Biceps TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.002 Brain Lower Grade Glioma_LGG_TCGA-VW-A8FI-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.10791 ZNF781 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87941 CL11 CCLE Cell Line Gene CNV Profiles -1.0 -1.6841 ONECUT3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 200.094 HNF4G JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0704 Rectum adenocarcinoma_READ_TCGA-AF-2690-01A-02R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TXNDC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42981 COLO 205 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07222 CRCGN014_HEPG2_3H:M01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01885 primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.54753 COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.829924 CD-26-MB82_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.245759 KE-37-MN32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.599827 MAPK11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16568 GCN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92297 IALM CCLE Cell Line Gene CNV Profiles 1.0 1.50516 JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23034 HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.8307 BC-01-JL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.309883 NCIH23 CCLE Cell Line Gene CNV Profiles 1.0 2.12573 Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6VB-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UACC257 CCLE Cell Line Gene CNV Profiles 1.0 1.67572 Embryonic stem cell_Embryoid body_Human CellMarker Gene-Cell Type Associations 1.0 null FOXC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 51.7568 Dmbx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.5882 outer SZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05721 CRCGN013_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.02966 PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.925362 ZNF362 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46028 RBM12B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69398 tail of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.11472 FAM86B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20864 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MIR122_OE_GDS3470_573_human_Embryonic stem cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null KMS27 DepMap CRISPR Gene Dependency 1.0 3.39639 A172 BioGPS Cell Line Gene Expression Profiles -1.0 -2.08881 RAJI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19301 FOXE1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 245.252 HCC2814 CCLE Cell Line Gene Expression Profiles 1.0 1.40788 CRCGN009_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.265 IOSE80 BioGPS Cell Line Gene Expression Profiles -1.0 -0.854086 BMI-1_DEPLETION_GDS2445_115_human_embryonic fibroblasts GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null HB-06-WU12_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.558159 Nr1h2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.0808 ONECUT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07625 RAB3IL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08385 imatinib_homo sapiens_gpl96_gds3043 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EFL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95468 ZC3H14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35068 MEF2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.1335 NKX2-8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.27 PAK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00565 COMMD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87341 RAB3A_Mutation - D77G point mutation_GDS2482_704_mouse_Hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null mRNA_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null TNK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44576 RCOR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73592 ACSM2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81546 KBTBD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49344 GSE216043_3_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-510 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.829924 MDST8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01861 PRMT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05195 A_CA_04_2009_4dayMOI-10^3_None_GSE37569 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.0022 ZNF669 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.54 Mecom JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 111.407 BHLHE40 ENCODE Transcription Factor Targets 1.0 null c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.27082 REST ENCODE Transcription Factor Targets 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5ED-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-1012-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-5275-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MI-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABPB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82939 Nkx2-1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.8157 TCF7L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05123 OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.85099 B3GAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07339 EE-03-SG02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.330879 PDE12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98161 SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.47459 GSE242083,GSE242098_3_v_1_med1_human RummaGEO Gene Perturbation Signatures 1.0 null SEMA3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52763 striatum_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.27957 Brain Lower Grade Glioma_LGG_TCGA-DU-A7TA-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Stat5a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.3387 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B7-01A-31R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null eGFP-FOS_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN009_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.47526 mRNA_CBX8_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null SLC29A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92973 Sarcoma_SARC_TCGA-HS-A5N9-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF7L1_01_346 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.18965 GSE135030_3_v_6_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN013_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.45961 SIRT3_KO_GDS4817_417_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null NKX2-2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.5236 primary auditory cortex (core)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.61537 Crus II, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.927168 TYK-NU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.31887 CRCGN015_HEPG2_48H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.17153 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5199-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Rectum adenocarcinoma_READ_TCGA-G5-6641-01A-11R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dentate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.939761 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Elf5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 43.5289 NDUFAF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7873 PK-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.43254 UQCRQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78244 PMC12619835-41467_2025_66007_MOESM13_ESM.xlsx-Sheet1-Basal_like_KLF5_peaks_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4696-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MOLM14 DepMap CRISPR Gene Dependency 1.0 3.8478 CAL-27 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.248 posteroventral (inferior) parietal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.20443 ventral medial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18419 hsa-miR-4768-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 globose nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.29667 IGR-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE219195_0_v_2_rbm12_human RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-5131-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.952622 SALL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82052 SKMEL2 CCLE Cell Line Gene Expression Profiles -1.0 -1.66567 TBC1D15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52284 ECI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27595 ZFAND5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60405 COL9A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44012 JUND_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Subcortical maternal complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.774 paracentral lobule, anterior part, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.46235 EC-62-OE64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.207241 SLC35A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49488 indusium griseum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10389 GSE145639_1_v_2_adar_human RummaGEO Gene Perturbation Signatures -1.0 null MHHCALL3 CCLE Cell Line Gene CNV Profiles -1.0 -1.67501 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TOP2B-26459242-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE216043_3_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF Rummagene Transcription Factor Associations 2026 1.0 null inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.889439 AE-85-KE62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.23189 PDX1_KO_GDS4348_360_mouse_Proximal small intestine GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GA-59-RW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.583704 LOX-1_OE_GDS4262_435_human_HAECT - aortic endothelial cell line - 24 Hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null IV, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.902055 ZZEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3273 EPLC272H CCLE Cell Line Gene CNV Profiles 1.0 1.84032 TARDBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60271 APECED - Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy_Thymic epithelial cell_GSE85 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.18139 primary auditory cortex (core)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.98917 RCOR1 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A5TT-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VA-48-RJ44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.219697 RRP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32243 U2OS DepMap CRISPR Gene Dependency 1.0 4.12811 Hmx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 41.2833 CEBPB ENCODE Transcription Factor Targets 1.0 null SNU1544 DepMap CRISPR Gene Dependency 1.0 2.17653 PRMT8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04765 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AV-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sox7 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 53.3706 CRCGN014_HEPG2_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.98 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ZFP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14807 PMC8120133-supplementarytables_ddab063.xlsx-Table_S2-Table_S2_Differentially_expressed_genes_in_DUX4-fl_and_DUX4-s_DUX4 Rummagene Transcription Factor Associations 2026 1.0 null G59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23034 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5109-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-18-3410-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MIA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84117 NCIH650 DepMap CRISPR Gene Dependency 1.0 2.18177 RPE1SS119 DepMap CRISPR Gene Dependency 1.0 4.406 Epi TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.993 SEZ6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19089 MOAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39451 TEAD4 ENCODE Transcription Factor Targets 1.0 null PMC10809641-DataSheet3.pdf-181-KDM2A_KDM2A Rummagene Transcription Factor Associations 2026 1.0 null MDAMB435S CCLE Cell Line Gene CNV Profiles 1.0 2.08026 CRCGN013_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.90767 CRCGN015_HEPG2_48H:P13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.62472 Hand1::Tcf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 51.6897 LF-94-HB11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.222669 TE-87-FM14_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.274257 HL60 BioGPS Cell Line Gene Expression Profiles 1.0 1.20792 F5 CCLE Cell Line Gene Expression Profiles 1.0 1.63335 AA-01-XV28_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.257105 Ascl2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 51.7635 NO10 DepMap CRISPR Gene Dependency 1.0 3.68359 MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01022 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6914-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lhx8 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.7739 PMC5105166-ncomms13331-s11.xlsx-Sheet1-Supplementary_Data_10_Overlap_of_upregulated_genes_in_MEF2D-rearranged_cases_with_public_ChIPseq_RNAseq_data_MEF2D Rummagene Transcription Factor Associations 2026 1.0 null MFH-INO COSMIC Cell Line Gene Mutation Profiles 1.0 null POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ACHN CCLE Cell Line Gene Expression Profiles -1.0 -2.1117 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20J-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE216043_10_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null BCL11B_KO_GSE9330_4_mouse_brain (striatum) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TM2D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61813 PCNX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41109 dorsolateral prefrontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.6956 MZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39409 Adrenomedullin receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.627 ZSCAN9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80728 Hamstring muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.936 AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.255131 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SOX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5078 H3K27me3_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PANC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.47459 Sarcoma_SARC_TCGA-MJ-A850-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor cortex (area M1, area 4)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.04345 ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Retinitis pigmentosa 11 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.052 ZYX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5331 inner CP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04913 paracentral lobule, posterior part, left, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.08551 CRCGN010_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.86095 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.011 ALVA31 BioGPS Cell Line Gene Expression Profiles 1.0 1.43209 GSE167474_2_v_0_naa40_human RummaGEO Gene Perturbation Signatures 1.0 null arteriosclerotic cardiovascular disease GWASdb SNP-Disease Associations 1.0 0.455936 NR3C1 JASPAR Predicted Transcription Factor Targets 1.0 null NCI-H23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30485 ventral posterior inferior nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.27002 POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A1OD-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP1 ENCODE Transcription Factor Targets 1.0 null PL4 DepMap CRISPR Gene Dependency 1.0 3.30941 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216043_7_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE216043_10_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null WIPI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67623 H3K27me3_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AMO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39884 Brain Lower Grade Glioma_LGG_TCGA-RY-A845-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inner SZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.917412 GSE195559_8_v_1_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null GK_KO_GDS2610_162_mouse_Brown adipose tissue GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null NCIH2347 CCLE Cell Line Gene Expression Profiles 1.0 1.44604 LOX-IMVI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.905638 ARID3A ENCODE Transcription Factor Targets 1.0 null SLITRK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87964 inner CP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.882277 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.950941 Nr2e1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 43.038 PJA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24272 GSE115542_5_v_1_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null CDYL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38166 ZNF354A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 71.1071 FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRR22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8394 posterior (caudal) superior temporal cortex (area 22c)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.842718 Adrenocortical carcinoma_ACC_TCGA-OR-A5KX-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DA-66-OE69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.395233 GSE165548_2_v_13_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null HMGN3 ENCODE Transcription Factor Targets 1.0 null PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Gene_Name_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null SG in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.91935 CRCGN010_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.27783 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.90542 MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.95857 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5703-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nfatc1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.4435 PHACTR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21803 SPCS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7594 ITPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22684 AMOTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38377 CRCGN017_MCF10A.WT.HP_24H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.20635 HTRA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.507 NCI-H2595 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.840888 EIF3K CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23091 SP1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4740-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZC3H12A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26965 GB-46-CK08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.389952 SCC-9 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.897523 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A85I-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.1313 nucleus accumbens, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.97917 NKX2-4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.9859 SREBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.3691 DERL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0726 Lef1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 52.4579 LS-411N COSMIC Cell Line Gene Mutation Profiles 1.0 null CPS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00659 TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KLK8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83768 Nr1h3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.8307 NCI-H2810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.841798 R2TP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.737 HAP-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.666 CRCGN014_HEPG2_24H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.33397 CRCGN015_MCF10A.TP53.M_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.88485 PIAS1-25552417-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null striatum_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.17892 layer II of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.854231 posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.07372 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RV-02A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NKX2-3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.6606 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DL-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIDT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25938 Polygenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.892 Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A3KJ-01A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23034 CRCGN013_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.5591 Lung adenocarcinoma_LUAD_TCGA-38-4625-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4352-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO 206F Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.22486 Foxj2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 145.121 TBP ENCODE Transcription Factor Targets 1.0 null Facioscapulohumeral muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.496 inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.99572 Lung squamous cell carcinoma_LUSC_TCGA-77-8154-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100391_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.30552 ALG10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44918 ZBTB12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1175 HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14393 CRCGN014_HEPG2_3H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.47653 ZSCAN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92109 TOLEDO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.0512 NDN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54462 HCT116 BioGPS Cell Line Gene Expression Profiles 1.0 1.89634 MAX ENCODE Transcription Factor Targets 1.0 null MEPCE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44463 SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.3591 BT483 CCLE Cell Line Gene CNV Profiles -1.0 -1.58665 RNASE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95184 medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.51271 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer I of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.37075 CRCGN017_MCF10A.TP53.M_24H:P21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.80803 Germ cell cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.221 RNF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07091 GSE216043_10_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null FAM110C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00903 SPI1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOXA13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.886 TMED3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27661 RPE1SS48 DepMap CRISPR Gene Dependency 1.0 2.44656 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70N-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02671 GET4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27982 AA-23-FM46_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.220114 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AG-06A-31R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null abducens nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00136 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HN-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STARD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.11811 TMEM259 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49761 PSME1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86704 SLC39A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07305 MKN7 COSMIC Cell Line Gene Mutation Profiles 1.0 null BCL11B_KO_GDS3178_296_mouse_striatum GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null AC-76-JB92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.231126 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4638-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QG-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VCAP CCLE Cell Line Gene Expression Profiles -1.0 -1.66903 KP-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null fertilizedegg BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.93651 POU2AF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73155 Hnf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.2602 ETFBKMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87905 Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.135 ZMIZ1 ENCODE Transcription Factor Targets 1.0 null CRCGN013_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.00341 Uterine Carcinosarcoma_UCS_TCGA-N6-A4VD-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WRNIP1 ENCODE Transcription Factor Targets 1.0 null MRPS34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54552 NRP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03155 Oral epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.897 ERA-21632823-H3396-HUMAN ChEA Transcription Factor Targets 2022 1.0 null HSD17B4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56283 STAT3 ENCODE Transcription Factor Targets 1.0 null Blastomere TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.384 ventrolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.23456 vomeralnasalorgan.VMO. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.16981 SARS-CoV MA15_Day2-C57BL6_None_GSE50878 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 3.8221 amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.52323 ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null RAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64315 DMS454 CCLE Cell Line Gene CNV Profiles 1.0 1.60311 H3K4me1_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null K562 BioGPS Cell Line Gene Expression Profiles 1.0 0.98177 frontal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.95794 MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.906491 SNU1272 CCLE Cell Line Gene Expression Profiles -1.0 -1.55151 BSX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40982 Uterine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.51 gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.47245 Lung squamous cell carcinoma_LUSC_TCGA-77-8140-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE216043_7_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null ACTR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54897 GULP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25546 HMG20A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64166 NFYB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFYB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAL1_megakaryocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Amniocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.843 Esrrg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.7176 primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.55501 496100472_PCx_possible Alzheimer's disease_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.67772 parasolitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.07376 hsa-miR-590-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 ST6GALNAC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05547 activation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Process Annotations 2023 1.0 null HSFX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07638 mRNA_KLF4_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.246792 Sox6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 43.7269 CRCGN013_HEPG2_24H:N13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.17278 Muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.787 muscular disease GWASdb SNP-Disease Associations 1.0 0.213459 supraoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2271 JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.502 parataenial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13097 MZ in caudal cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.923931 TNK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17189 U251 BioGPS Cell Line Gene Expression Profiles -1.0 -0.987104 Extravillous trophoblast cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.962 striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.848385 Lung adenocarcinoma_LUAD_TCGA-38-4632-01A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsal thalamus_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.913441 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3445-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF496 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77624 WDR74 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51042 JUND_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FSCN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83757 A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_1day-MOI-10^3_None_GSE43302 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.55147 OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.94767 CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ME-31-RM40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.349434 Foxj3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 149.958 Oral cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.761 laterodorsal part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.42568 PRRX2 JASPAR Predicted Transcription Factor Targets 1.0 null FOXF2 JASPAR Predicted Transcription Factor Targets 1.0 null ChIP_SETDB1_19884257 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A614-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100368_PCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.6223 NUPR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52993 Atf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.2074 GSE122425_1_v_0_nsun2_human RummaGEO Gene Perturbation Signatures 1.0 null CYBC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95826 HIRA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82299 SP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.891558 primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.1234 CRCGN015_HEPG2_48H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.53328 ARFIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23625 mRNA_ZSCAN4C_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null emboliform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.943018 METRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8713 RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.42899 Anterior visceral endoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.853 RNASE6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47218 COLO 201 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.829924 ISCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36115 BC-54-ON71_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.220648 Gfi1b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 53.0415 RNMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68672 SAC3D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55826 IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.3523 Acute Myeloid Leukemia_LAML_TCGA-AB-2812-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-8660-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BOKU DepMap CRISPR Gene Dependency 1.0 2.1524 NCIH1650 CCLE Cell Line Gene CNV Profiles -1.0 -1.3695 ZNF716 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.12536 HEATR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77979 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7055-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCTS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49044 amygdaloid complex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.886917 atherosclerosis GWASdb SNP-Disease Associations 1.0 0.811614 VD-76-SO91_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.311577 SNB19 BioGPS Cell Line Gene Expression Profiles -1.0 -1.38876 SNU1214 CCLE Cell Line Gene Expression Profiles 1.0 1.96461 Sarcoma_SARC_TCGA-HB-A3YV-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-AAVH-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE192860_0_v_1_trifluoperazine_human RummaGEO Drug Perturbation Signatures 1.0 null ESRRG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38277 HDAC6_KO_GDS4375_532_mouse_Foxp3(+) Tregs GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null RDH10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35328 Lung squamous cell carcinoma_LUSC_TCGA-46-6026-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100542_PCx_no dementia_no TBI_82_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.12111 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.61749 496100488_TCx_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.46573 RUNX2 JASPAR Predicted Transcription Factor Targets 1.0 null MDA-MB-231 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.38664 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J8-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC6_KO_GDS4375_372_mouse_CD4+CD25+ T-regulatory cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PAX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1247 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4332-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAGEL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63785 CRCGN009_HEPG2_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.0288 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7917-01A-11R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9307901-mmc2.xlsx-S5-GATA6-AS1_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null TSEN34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32855 CAKI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.980912 Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.008 CRCGN010_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.816 PHPT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79858 PLEKHO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92628 STK40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9586 CRCGN015_HEPG2_48H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.85894 DD-36-YH76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.356424 G118 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.988578 Dmrt1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.3171 WDR82 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56877 GSE150072,GSE169209_6_v_9_qser1_human RummaGEO Gene Perturbation Signatures -1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2978-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FE-64-KC49_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.238409 NFYA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.5451 MALME 3M BioGPS Cell Line Gene Expression Profiles 1.0 0.862112 CRCGN011_HEPG2_24H:L12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.85545 KYSE270 DepMap CRISPR Gene Dependency 1.0 4.45587 cerebellar cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.55283 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A3KG-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZC3H12B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1726 CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34688 SP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.89959 NEUROD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32131 CRCGN016_MCF10A.TP53.M_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.52677 IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.458465 MDAMB175VII CCLE Cell Line Gene Expression Profiles -1.0 -1.52236 FSBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.95183 Decidual stromal cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.798 MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKN DepMap CRISPR Gene Dependency 1.0 3.32555 KASUMI2 CCLE Cell Line Gene CNV Profiles -1.0 -1.59082 NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19379 RRM2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8246 magnocellular division of VA Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.963583 BC-54-ON71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.488688 COLO775 CCLE Cell Line Gene CNV Profiles 1.0 1.80106 GSE216757_4_v_1_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null COLO679 CCLE Cell Line Gene Expression Profiles -1.0 -1.56635 MID1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06925 CRCGN017_MCF10A.TP53.M_24H:I01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00515 TECPR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20374 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68D-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR1D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08645 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FUOV1 CCLE Cell Line Gene Expression Profiles -1.0 -1.99133 GSE135030_3_v_9_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null GATA5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6911 DHCR24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85564 GPR161 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77095 dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 3.33678 DUX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.0025 TMEM106A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18725 THRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 63.1406 PGM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84771 Primary pulmonary hypoplasia_Lung Tissue_GSE1363 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.43781 ATF3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.13246 K029AX CCLE Cell Line Gene Expression Profiles -1.0 -1.71328 DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.47459 ROCK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28775 MSANTD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17405 dorsolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.76345 CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.981594 ZFP42 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.2477 VAESBJ DepMap CRISPR Gene Dependency 1.0 3.06377 JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.9433 GSE85565_1_v_0_tcf21_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN011_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.0028 CRCGN011_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.14735 CRCGN008_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.2306 INA6 DepMap CRISPR Gene Dependency 1.0 3.32017 GSE206729_4_v_0_trps1_human RummaGEO Gene Perturbation Signatures 1.0 null PPP1CA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97212 PPFIA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92597 CRCGN008_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8032 bewo HPA Cell Line Gene Expression Profiles 1.0 2.61208 ITPRIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59331 Myoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.583 HCC366 CCLE Cell Line Gene Expression Profiles 1.0 1.42217 hippocampus (hippocampal formation)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.18719 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JM-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A.TP53.M_24H:L10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2556 dorsolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.857863 cortico-medial group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.906478 CCDC50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51726 H4K20me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Smad4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.139 CRCGN015_MCF10A.WT.HP_24H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.34538 Melc TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.924 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.54719 Brain Lower Grade Glioma_LGG_TCGA-RY-A83Z-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE206516,GSE206518_6_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.918194 KCL-22 COSMIC Cell Line Gene Mutation Profiles 1.0 null THP1 CCLE Cell Line Gene CNV Profiles 1.0 1.37224 GSE216043_3_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Crus I, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.854604 PB-18-HD85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.285595 Msx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.124 Npas4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.9127 EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.21683 layer I of piriform cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.985216 COLO678 CCLE Cell Line Gene CNV Profiles -1.0 -1.75963 FOSL1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-7221-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUCLG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65753 Epiblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.526 DIPK1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9295 TNKS_INHIBITION_GDS5029_281_human_SW480 KRAS-mutant colorectal cancer cell line - 16hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null SG in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.80017 GZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.07103 Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.47849 H3K23me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null raphe nuclei of medulla Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12684 FF-86-NH56_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.357506 CRCGN014_HEPG2_24H:M23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.27509 Cell surface furrow COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.493 MORCPR CCLE Cell Line Gene CNV Profiles -1.0 -2.4359 H2BK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02322 JUN ENCODE Transcription Factor Targets 1.0 null Visceral endoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.736 dorsolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.963241 SRGAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67528 VPS37D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95311 496100413_FWM_probable Alzheimer's disease_no TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.28219 MYH14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44772 MA-88-CA03_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.229376 POMC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34934 Extravillous trophoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.916 NMB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95767 RERFGC1B CCLE Cell Line Gene CNV Profiles 1.0 1.73875 BCL6B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.888 POU3F4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85117 MEF2A JASPAR Predicted Transcription Factor Targets 1.0 null CRCGN012_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0745 WC-16-IR43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.259262 posteroventral (inferior) parietal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.859311 mRNA_TCF7L2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Facioscapulohumeral muscular dystrophy 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.718 SEMK2 DepMap CRISPR Gene Dependency 1.0 3.2373 USP44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92254 RIDA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5089 FOXS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35934 HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07751 HT1197 CCLE Cell Line Gene Expression Profiles 1.0 1.68169 layer VI of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.53262 Kidney Chromophobe_KICH_TCGA-KN-8432-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USP2_KO_GSE43517_20_mouse_kidney GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null HESX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.219 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.832341 BD-49-MD69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.231761 TCCSUP CCLE Cell Line Gene Expression Profiles -1.0 -1.53852 Connecting stalk TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.104 arteriosclerosis GWASdb SNP-Phenotype Associations 1.0 0.273648 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63W-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LMAN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57896 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51R-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CBX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23854 TFAP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.6143 SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.980891 Nfat5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.7107 RAJI COSMIC Cell Line Gene CNV Profiles 1.0 4.51153 KYAE-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4841-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H4K8ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NR1D1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.8861 posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.34984 Nanog JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 44.8427 Nr1h3::Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.9921 nucleus accumbens, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01951 PBXIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02043 RNF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7738 KBTBD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94541 EKVX BioGPS Cell Line Gene Expression Profiles -1.0 -1.47533 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63T-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE135030_3_v_4_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null Ptf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 100.031 PIGU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48871 NCI-H1869 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45434 IC-05-AW29_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.347766 HSPBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8463 TET1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31397 RH18 CCLE Cell Line Gene Expression Profiles -1.0 -1.73948 CRCGN008_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.1998 SP1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rhabdomyosarcoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.697 USP2_KO_GDS5079_25_mouse_kidney GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-WY-A85E-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ADCY3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65374 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LOX-1_OE_GDS4262_432_human_HAECT - aortic endothelial cell line - 2 Hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE195514_0_v_1_stk25_human RummaGEO Gene Perturbation Signatures -1.0 null KMRC3 CCLE Cell Line Gene CNV Profiles -1.0 -1.48249 CRCGN010_HEPG2_24H:J03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.65897 Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A654-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAB11B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40808 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DE-01A-22R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.824906 DIABLO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2478 Myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.544 Digenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.964 SNU899 CCLE Cell Line Gene Expression Profiles 1.0 1.94663 orbital frontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.847949 MKN7 CCLE Cell Line Gene Expression Profiles 1.0 1.64462 peripheral portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.919905 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C3-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null midbrain reticular formation, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.0667 SK-MEL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15253 CRCGN013_HEPG2_24H:H22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.12312 superior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.36023 TNPO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56582 IZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.989342 U87MG CCLE Cell Line Gene CNV Profiles -1.0 -1.37137 RNF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15428 RH30 CCLE Cell Line Gene CNV Profiles 1.0 2.6528 Nr1h4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.31 Tcf12 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.4277 CRCGN012_HEPG2_24H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.11061 A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_1day-MOI-10^3_None_GSE44445 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.8243 NRL_Deficiency_GDS1693_236_mouse_Photoreceptors cells of retinas at P2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-60-2724-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.31393 YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VAX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.0089 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.827797 LHX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.9056 PCDH8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01604 Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 UROD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66679 PDRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92321 hippocampus (hippocampal formation)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.919351 NTMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83647 U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.72099 CCRT CEM BioGPS Cell Line Gene Expression Profiles 1.0 1.06026 AVPI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80393 TRMT10C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57922 CRCGN013_HEPG2_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.81976 SARS-BatSRBD_Day1_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.01725 GSE168401_2_v_3_harmine_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A6HP-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MGA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.2425 HOXC13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0072 AA-22-UI44_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.210182 GPX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83119 CRCGN011_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.72395 Lymphoma_burkitts(Daudi) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.851927 HOXC9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0777 SG in dysgranular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02968 MARCHF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1057 WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FC-20-EQ58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.278486 TOLEDO CCLE Cell Line Gene CNV Profiles -1.0 -1.91723 HSF1_KD_GDS1733_752_human_HeLa cells - 2 Hour by siHSF1_1 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07751 Zfp809 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 37.5946 Prdm15 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 55.6156 NCIH1915 CCLE Cell Line Gene Expression Profiles 1.0 1.76631 CAMA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.30124 GSE210662_2_v_1_znf165_human RummaGEO Gene Perturbation Signatures 1.0 null Dlx4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.4219 H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142210_3_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null a431 HPA Cell Line Gene Expression Profiles 1.0 1.51725 DGCR8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56365 SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01022 NR1D2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.4549 CARMIL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05381 H3K27me3_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKMEL3 CCLE Cell Line Gene Expression Profiles -1.0 -1.58495 Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A1QT-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-6743-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN009_HEPG2_24H:F20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.5248 Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SU-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RARA_01_51 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.61143 CRCGN016_MCF10A.WT.HP_24H:G10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.09082 SERPINF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.33778 ATF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.8038 ZKSCAN5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.3754 substantianigra BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.14365 HDAC6_KO_GSE27896_383_mouse_Foxp3+ T-regulatory cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null CAOV4 CCLE Cell Line Gene Expression Profiles -1.0 -1.71131 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5001-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OCI-LY-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.68202 FOS JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4572 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5010-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BC-54-ON71_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.817475 VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.3122 JUND JASPAR Predicted Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JU-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:I24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5745 SP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -3.24284 HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.891931 Msgn1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.786 EP300 ENCODE Transcription Factor Targets 1.0 null CHST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65147 GPC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84227 G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.892675 cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.889813 Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.6652 Tcf21 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 39.9212 RS11846 BioGPS Cell Line Gene Expression Profiles 1.0 0.910028 primary motor cortex (area M1, area 4)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.90163 Rectum adenocarcinoma_READ_TCGA-AF-2689-11A-01R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null