association	dataset	threshold value	standardized value
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_7_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
4805_MAP2K7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.27344
1652_CLHC1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.567529
GSE102505_6_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
859_BMS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.524449
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	1.0	null
Esophageal squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.045
GSE198794_2_v_1_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160817_4_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE130437_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
1578_CHML_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.617373
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.2534
GSE216043_10_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.868081
GSE225869_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
U2-type spliceosomal complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.647
1929_CTDP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.50204
5762_NPAT_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.697764
5791_NR2E1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.584421
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.44951
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.589101
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
4931_MED11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519128
8653_TAF12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.710925
GSE130437_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
6290_PHF3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.540342
2784_EXOC7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.667262
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.607351
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chr16_31702418_C_T_b38	GTEx eQTL 2025	1.0	2.76791
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_7_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
5677_NIPBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.551938
GSE189772,GSE189773_3_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
4955_MED4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.528656
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.549063
GSE133087_5_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE225869_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135350_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE219195_4_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Wes	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
1788_COPZ1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09494
7427_RPF2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07897
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
4955_MED4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.19358
Perineuronal net	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.804
7569_RRS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.512541
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
2203_DHX15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.733788
GSE147876,GSE147877_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TZM-bl cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.333
3504_GPN3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.521423
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.816656
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505354
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Gene expression (Transcription)	Reactome Pathways 2024	1.0	null
GSE214931_4_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MHC class I protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.746
chr16_31717723_A_G_b38	GTEx eQTL 2025	1.0	1.19085
6542_POLR2C_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.700657
6625_PPIE_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.597887
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.532811
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE161170,GSE161268_0_v_2_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.63404
chp212	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.181
4953_MED30_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05585
8272_SON_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.617126
GSE178714_6_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178267_2_v_0_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE121824,GSE121826_0_v_3_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
CAL-27 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.861
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.58126
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200982_0_v_2_plac8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE102505_6_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.911176
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.693217
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
7509_RPS19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.841445
GSE148200_3_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
4593_LIN52_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.539442
GSE148200_0_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SK-N-AS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.676
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.909645
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RNA Polymerase II Transcription	Reactome Pathways 2024	1.0	null
GSE171572_5_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
6544_POLR2D_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.777696
GSE215086_3_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Kidney - Medulla	GTEx Tissue Gene Expression Profiles 2023	1.0	4.00371
GSE233049_1_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_6_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
1860_CREB3L3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.536778
10738_ZWINT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519424
GSE190316,GSE190324_0_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195559_0_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
2858_FAM136A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.56084
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216273,GSE216292_14_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.984421
GSE210101,GSE210114_6_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213228_4_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_15_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE150134_1_v_0_scn5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.806601
Generic Transcription Pathway	Reactome Pathways 2024	1.0	null
imr5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.066
GSE171180,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
9473_U2AF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.520938
Tongue cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.562
GSE198794_2_v_3_usp18_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184892_0_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE244518,GSE244520_1_v_0_dnmt3b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171572_0_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_6_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.595661
SK-N-FI cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.392
GSE178714_6_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE94849_6_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102505_1_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
8227_SNRPC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.520327
4957_MED7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.637319
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135030_8_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE145639_7_v_4_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
SCC-25 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.028
7607_RUVBL1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.802655
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Large cell neuroendocrine carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.725
GSE219195_4_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217776,GSE217829_1_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
8598_SUPT5H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.945886
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.530204
GSE142210_4_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5731_NOC4L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.502545
8222_SNRNP70_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.534347
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Urinary bladder	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
9962_ZBED2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.765149
GSE183113_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.508494
6059_TENT2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.517688
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE164529_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4950_MED27_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08386
575_ASCL3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.610235
GSE202434,GSE202438_10_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE157684,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	1.0	null
6548_POLR2G_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.766975
7463_RPL35_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.529194
6846_PSMA6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02152
LAN-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.556
6541_POLR2B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.773604
1013_C18ORF32_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519957
4951_MED28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.543129
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
2858_FAM136A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.524746
4939_MED17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.817779
GSE133764_2_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
8272_SON_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.512699
6060_TENT4B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505447
GSE175787_13_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCC-15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.235
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
8759_TBX5_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563584
GSE156923_2_v_1_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.769651
GSE230263,GSE230265_5_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
7424_RPAP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.15909
1200_KNL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.34008
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102505_1_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
4942_MED1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.639132
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
6549_POLR2H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.538862
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE106661,GSE106665_0_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180468_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	3.92728
GTEx Esophagus 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	18.2351
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.663417
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.50058
GSE225869_1_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
8680_TANGO6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.07117
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Uterus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.601783
GSE210682_2_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE133764_1_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135030_8_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE156923_0_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
9426_TUBGCP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.713779
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0384
GSE125014_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_11_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE133763_0_v_1_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE99687_3_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	1.0	null
10123_ZIC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.61639
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.32907
GSE152441,GSE152442_6_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
4940_MED18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.508029
GSE186440,GSE186443_0_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7607_RUVBL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.783856
GSE135030_11_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE155031_5_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160765_2_v_1_twist1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240468_3_v_2_nfyc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.03796
GSE158834_10_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE94849_3_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
105_ACTG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.751071
2542_EIF2S2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.29991
Bladder	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE233679_14_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
chr16_31816541_C_T_b38	GTEx eQTL 2025	1.0	1.5868
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135350_3_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
9656_USP39_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.641536
2376_DROSHA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.800537
GSE158834_10_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
4957_MED7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.909854
4371_KIAA1958_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.740973
GSE158834_2_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226439,GSE226441_6_v_2_hnf4g_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239844_11_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.648419
GTEx Stomach 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	4.51916
GSE219195_1_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
MHC protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.824
GSE147876,GSE147877_4_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.723958
GSE135030_8_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE197630_1_v_0_ruvbl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171179,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.909482
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248769_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178714_6_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.08636
7829_SF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.903284
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.657173
GTEx Skin 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	8.10131
GSE160817_5_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE225869_1_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Oral squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.988
Corticotropic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.537
4939_MED17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504063
GSE215086_3_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.534545
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.507316
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
9804_WDR12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.535219
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.58124
6548_POLR2G_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.23765
GSE184892_6_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0