association	dataset	threshold value	standardized value
hsa-miR-140-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
PPP2R1B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K75999096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01687
GSE210885_0_v_4_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cornified envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
HBA2	Pathway Commons Protein-Protein Interactions	1.0	null
KM12	BioGPS Cell Line Gene Expression Profiles	1.0	1.11321
GTEX-WI4N-2726-SM-3LK7Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03322
ATP5I	Pathway Commons Protein-Protein Interactions	1.0	null
epidermal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.31694
SLC25A5	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BFTC-905	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IDI1	Pathway Commons Protein-Protein Interactions	1.0	null
Juxtaglomerular cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.61
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
MYL12B	Pathway Commons Protein-Protein Interactions	1.0	null
PSMC1	Pathway Commons Protein-Protein Interactions	1.0	null
Antler	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.546
keratinocyte activation	GO Biological Process Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8110-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K93101873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02224
KRT78	Pathway Commons Protein-Protein Interactions	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28125
DSC2	Pathway Commons Protein-Protein Interactions	1.0	null
PAN2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XPVG-2626-SM-4B669	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28638
PSMD13	Pathway Commons Protein-Protein Interactions	1.0	null
FLI1_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRPF40A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K49051633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34433
MCF-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.964512
PRDX1	Pathway Commons Protein-Protein Interactions	1.0	null
RFC4	Pathway Commons Protein-Protein Interactions	1.0	null
LPAR5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00480034
NCIH3255	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49695
SOX17_OE_GDS3300_124_human_HESC (CA1 and CA2)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
HNRNPUL1	Pathway Commons Protein-Protein Interactions	1.0	null
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PPP2R5B	MSigDB Cancer Gene Co-expression Modules	1.0	null
klf4_17017123_rko_gof_human_gpl96_gds1942	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.120575
Ichthyosis	DisGeNET Gene-Disease Associations	1.0	null
GSE149880_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RAPGEF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00695602
GTEX-X261-0011-R6B-SM-4E3J8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890327
ficolin-1-rich granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.773
abnormal keratinocyte differentiation	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K07396550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54796
dg1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.875
BRD-K59970200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72954
BRD-K60948317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06903
ETV5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7178
AP2B1	Pathway Commons Protein-Protein Interactions	1.0	null
MAPACHS77	DepMap CRISPR Gene Dependency	1.0	2.53123
RPL13	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4745-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ATP1A1	Pathway Commons Protein-Protein Interactions	1.0	null
HK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0054678
BLVRB	Pathway Commons Protein-Protein Interactions	1.0	null
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.07482
kidney disease	GWASdb SNP-Disease Associations	1.0	0.178613
G3BP1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_Jurkat_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.74664
genetic	GeneRIF Biological Term Annotations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7425-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K06367273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21446
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
pavement epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.543359
GTEX-WRHK-1426-SM-3MJF9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09751
Feather	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.3
PMC9692021-Table_4.xlsx-Table_S4-Table_S4_405_DEGs_of_RA_synovial_tissues_between_NFIL3-high_and_NFIL3-low_group_NFIL3	Rummagene Transcription Factor Associations 2026	1.0	null
Extracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
keratinization	GeneRIF Biological Term Annotations	1.0	null
Thin Skin	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K06029218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1062
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-P4QT-0126-SM-2I3FL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69408
BRD-K66189308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95109
HDAC1	Pathway Commons Protein-Protein Interactions	1.0	null
increased ear pigmentation	MGI Mouse Phenotype Associations 2023	1.0	null
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ARG1	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
A-CA-04-2009(H1N1)_48Hour_None_GSE37571	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.62837
GATA1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TUBB	Pathway Commons Protein-Protein Interactions	1.0	null
HCRTR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.005027
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPL10	Pathway Commons Protein-Protein Interactions	1.0	null
LGALS3BP	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q734-0326-SM-48U15	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
POLR2A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K75961186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02367
Brain Lower Grade Glioma_LGG_TCGA-DB-A4XH-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877873
locomotion	GO Biological Process Annotations 2015	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
extracellular region part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Lung adenocarcinoma_LUAD_TCGA-50-5055-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ectodermal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.272
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0797
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
PMC11923864-ADVS-12-2413713-s002.xlsx-Fe3O4_SiO2_NP_of_LTF_spike-in-Unnamed_0_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K00542622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13429
GTEX-Q2AG-0126-SM-33HBV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43522
DHX15	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPAB	Pathway Commons Protein-Protein Interactions	1.0	null
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50318
GTEX-R55G-1226-SM-48FDC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
KRT15	Pathway Commons Protein-Protein Interactions	1.0	null
HSF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0227
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.953626
KRT12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00686477
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
NDUFA4	Pathway Commons Protein-Protein Interactions	1.0	null
SF3A1	Pathway Commons Protein-Protein Interactions	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.267
PCBP1	Pathway Commons Protein-Protein Interactions	1.0	null
CBR3	Pathway Commons Protein-Protein Interactions	1.0	null
SRF	JASPAR Predicted Transcription Factor Targets	1.0	null
SMAD3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K87176777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.0013
GNAI3	Pathway Commons Protein-Protein Interactions	1.0	null
GLB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00366748
IL33	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00731993
TIA1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.WT.HP_24H:F12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0252
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K49875070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05034
dermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.155224
CLIC5	Pathway Commons Protein-Protein Interactions	1.0	null
ADK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00569965
uterus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-4253	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Dermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.809
RUNX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3196
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.95092
ZNRD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00478383
CCT5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K21443215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17615
LMBR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00704299
MCM6	Pathway Commons Protein-Protein Interactions	1.0	null
Skin cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.329
CAPNS1	Pathway Commons Protein-Protein Interactions	1.0	null
BCAN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00659211
ARHGAP15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00484816
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_proteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04695511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45274
cellular process	GO Biological Process Annotations 2015	1.0	null
RRS1	Pathway Commons Protein-Protein Interactions	1.0	null
MTHFD1	Pathway Commons Protein-Protein Interactions	1.0	null
KDM5A	ENCODE Transcription Factor Targets	1.0	null
LARS	Pathway Commons Protein-Protein Interactions	1.0	null
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1926
Basal cell_Skin_Human	CellMarker Gene-Cell Type Associations	1.0	null
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.856352
GTEX-QDVJ-0626-SM-48U1T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-S7SE-0826-SM-4AT4D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08972
X-linked chondrodysplasia punctata 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.568
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YQ-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MBD6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00490285
Protein phosphatase 4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.782
SRD5A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00810546
ASCL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00772173
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.93615
intermediate filament cytoskeleton	GO Cellular Component Annotations 2023	1.0	null
GTEX-WFON-1226-SM-3TW8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
FST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00701692
Edema	CTD Gene-Disease Associations	1.0	1.04757
GATA2-19941826-K562-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
15705876-TableS5	GeneSigDB Published Gene Signatures	1.0	null
COMT	Pathway Commons Protein-Protein Interactions	1.0	null
Forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
TUBB1	Pathway Commons Protein-Protein Interactions	1.0	null
HDAC6	Pathway Commons Protein-Protein Interactions	1.0	null
preweaning lethality, incomplete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
muscle fibre	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.179399
ATG4B	Pathway Commons Protein-Protein Interactions	1.0	null
CSE1L	Pathway Commons Protein-Protein Interactions	1.0	null
oral cavity cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.476014
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040983
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.4087
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.914035
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7007
Liver hepatocellular carcinoma_LIHC_TCGA-DD-AA3A-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stratum spinosum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.22871
BRD-K64299311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33351
primary motor cortex (area M1, area 4)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.959505
Hoof	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.937
Genital mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.623
Keratoderma	DisGeNET Gene-Disease Associations	1.0	null
one	GeneRIF Biological Term Annotations	1.0	null
SW 480	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.851
SOCS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09541
Male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.55
PMC10616317-mmc4.xlsx-AF-MSC-EXOvsAF-MSC-CM-Table_S5_Related_to_Figures_4_and_6A_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
JHH-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SQSTM1_OE_GDS2653_651_human_IMR-32 neuroblastoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
ERBB4-ERBB4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.689
intracellular part	GO Cellular Component Annotations 2015	1.0	null
Extracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K64451058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55075
GTEX-XMD1-0008-SM-4AT41	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
YBEY	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF510	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K11893906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52633
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.05312
abnormal skin pigmentation	MPO Gene-Phenotype Associations	1.0	null
abnormal outer ear morphology	MPO Gene-Phenotype Associations	1.0	null
TROVE2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K04092807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51594
Hair follicle bulge stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.846
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.454
PPP2CB	Pathway Commons Protein-Protein Interactions	1.0	null
CHMP2A	Pathway Commons Protein-Protein Interactions	1.0	null
TPR	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K35035851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05331
SF3B2	Pathway Commons Protein-Protein Interactions	1.0	null
SEPT7	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12069319-Table1.xlsx-OCAB_p40_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.283191
PSPC1	Pathway Commons Protein-Protein Interactions	1.0	null
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33399
GTEX-U412-0426-SM-3DB9O	GTEx Tissue Sample Gene Expression Profiles	1.0	2.6033
GR	MotifMap Predicted Transcription Factor Targets	1.0	null
TGBC1TKB	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.6874
BRD-K29328696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06249
NOP56	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_10681_KO_Gtf2ird1_SRP074330	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
HSP90AA1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XV7Q-1826-SM-4BRUV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979297
abnormal testis morphology	IMPC Knockout Mouse Phenotypes	1.0	null
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4202
NCIH596	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34273
SNRPD3	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFY	Pathway Commons Protein-Protein Interactions	1.0	null
uterine endometrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.553683
MFAP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00560501
GTEX-S341-0226-SM-2XCAX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949547
SRSF6	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55G-0426-SM-48FDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
SERTAD4	Pathway Commons Protein-Protein Interactions	1.0	null
SNU216	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40962
enteroendocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.40328
TAL1_megakaryocyte_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K40088786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45531
cas1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.245
HNRNPC	Pathway Commons Protein-Protein Interactions	1.0	null
Wt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	97.0305
IGFBP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00491379
KRT6A	Pathway Commons Protein-Protein Interactions	1.0	null
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	1.0	2.09923
CHCHD3	Pathway Commons Protein-Protein Interactions	1.0	null
TUBA4A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K95798946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07486
psoriasis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.291539
FOXH1-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K85284710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02653
BRD-K69080049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59115
IMPDH2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K79048835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07921
RPL24	Pathway Commons Protein-Protein Interactions	1.0	null
RPLP0	Pathway Commons Protein-Protein Interactions	1.0	null
DSG1	Pathway Commons Protein-Protein Interactions	1.0	null
Melanocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.669
PDE1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0054307
BRD7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00500866
abnormal renal physiology	GWASdb SNP-Phenotype Associations	1.0	0.22747
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4XL-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
leaf lamina	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.242363
epidermal thickening	HPO Gene-Disease Associations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8RY-11A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MRPS34	Pathway Commons Protein-Protein Interactions	1.0	null
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.879449
fluvastatin-3370	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE145915_5_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XGQ4-2626-SM-4AT6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PMC12271601-mmc2.xlsx-OUT_cells_02-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UJMC-1926-SM-3GADS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82655
PRKACA	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87273
orbital frontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.39914
BRD-K89328601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12109
DPF2	Pathway Commons Protein-Protein Interactions	1.0	null
NCO2	CCLE Cell Line Gene Expression Profiles	1.0	1.39264
developmental process	GO Biological Process Annotations 2015	1.0	null
BRD-K12347309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19968
Sebaceous gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
lomefloxacin-3620	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Spinal cord	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.467
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.09749
GTEX-PX3G-1426-SM-48U1J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834542
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.873647
BRD-K85357344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01067
LILRB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00742824
Stratum granulosum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.04
GTEX-U3ZN-0726-SM-4DXT5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
CCT2	Pathway Commons Protein-Protein Interactions	1.0	null
RPS8	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K12099407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55184
GTEX-SN8G-0526-SM-32PLE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
extracellular space	GO Cellular Component Annotations 2015	1.0	null
PRPF39	Pathway Commons Protein-Protein Interactions	1.0	null
EED	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5009-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skin carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.163317
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4464
GTEX-QMR6-0008-SM-447AV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
PLXNA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00440489
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AQ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOSL1	MSigDB Cancer Gene Co-expression Modules	1.0	null
PRPF6	Pathway Commons Protein-Protein Interactions	1.0	null
EMG1	Pathway Commons Protein-Protein Interactions	1.0	null
DRG1	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1155	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.707
HNRNPD	Pathway Commons Protein-Protein Interactions	1.0	null
RPS6KA4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U4B1-1126-SM-4DXV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
MET	Pathway Commons Protein-Protein Interactions	1.0	null
RPA2	Pathway Commons Protein-Protein Interactions	1.0	null
MAGI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520784
LDHA	Pathway Commons Protein-Protein Interactions	1.0	null
HIST1H1E	Pathway Commons Protein-Protein Interactions	1.0	null
EEF1B2	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.638434
CA11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00525749
HIST1H1C	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH1693	CCLE Cell Line Gene CNV Profiles	1.0	1.93515
GTEX-PWOO-0626-SM-48TZH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
Prostate adenocarcinoma_PRAD_TCGA-FC-7961-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WYJK-0526-SM-3NM8Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.993813
HCC202	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.952847
PF-382	GDSC Cell Line Gene Expression Profiles	1.0	1.88264
BRD-K47650707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80673
GTEX-Q2AG-0326-SM-48U1O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13107
GTEX-QDT8-0426-SM-32PKZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
CCDC158	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00663572
BUB1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00463862
HMGA1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K64345025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09008
intermediate filament cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ADH5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00412304
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
MDAMB436	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.61818
enlarged kidney	MGI Mouse Phenotype Associations 2023	1.0	null
PSMD2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WFG8-2226-SM-3GIL9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24685
BRD-K54042694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24161
ILK	Pathway Commons Protein-Protein Interactions	1.0	null
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q734-0008-SM-48U2I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899895
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980682
Testis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.5
IGKV1-5	Pathway Commons Protein-Protein Interactions	1.0	null
IFIT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00970636
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	2.91025
WDR36	Pathway Commons Protein-Protein Interactions	1.0	null
JM1	DepMap CRISPR Gene Dependency	1.0	2.19044
Alveolar mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.67
H413	DepMap CRISPR Gene Dependency	1.0	2.44522
GSE114883_0_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPS19	Pathway Commons Protein-Protein Interactions	1.0	null
NUGC-4	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.66709
abnormal epidermis suprabasal layer morphology	MGI Mouse Phenotype Associations 2023	1.0	null
diabetic nephropathies	GAD Gene-Disease Associations	1.0	null
GSE182680,GSE182683_7_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
chlorambucil-4345	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-U3ZH-0426-SM-4DXSE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
BRD-A20018680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49057
THOC6	Pathway Commons Protein-Protein Interactions	1.0	null
Atherosclerosis_Aorta Smooth Muscle Tissue_GSE420	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.41741
S100A8	Pathway Commons Protein-Protein Interactions	1.0	null
ANK2	Pathway Commons Protein-Protein Interactions	1.0	null
colo800	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.657
TYK-NU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900566
STBD1	Pathway Commons Protein-Protein Interactions	1.0	null
ACSM5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00577137
KLRD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00863634
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-U3ZN-0008-SM-4DXTL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
NPM1	Pathway Commons Protein-Protein Interactions	1.0	null
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.621804
PRKAG2	Pathway Commons Protein-Protein Interactions	1.0	null
16489042-SuppTable1a	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XMD1-0826-SM-4AT52	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861355
CL-40	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50318
DECR1	Pathway Commons Protein-Protein Interactions	1.0	null
EWSR1	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8HL-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100364_TCx_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.49864
keratinocyte proliferation	GO Biological Process Annotations 2025	1.0	null
CCAR1	Pathway Commons Protein-Protein Interactions	1.0	null
CAL-33	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KCNMA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00558542
GSE182680,GSE182683_0_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WFON-2126-SM-3LK7O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66732
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.96986
CNBP	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Table_S2_List_of_TAL1_UTX_co-bound_genes_in_Jurkat_cells_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
PRKAA2	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
TARDBP	Pathway Commons Protein-Protein Interactions	1.0	null
DYNLRB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00534234
hsa-miR-4657	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
SYK	Pathway Commons Protein-Protein Interactions	1.0	null
SW1088	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PPP2CA	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PSDG-0226-SM-33HC1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49838
DNM2	Pathway Commons Protein-Protein Interactions	1.0	null
MSMO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00662738
BRD-K40175214_torin-1_HS578T_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1926
UTP18	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.663
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
ITGB1	Pathway Commons Protein-Protein Interactions	1.0	null
siemens	GeneRIF Biological Term Annotations	1.0	null
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14932
VASP	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K80950551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73656
Perturb_18379_KO_Izumo1r_SRP354764	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.13407
DDX5	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X5EB-1926-SM-4E3IW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12471
GTEX-N7MT-0126-SM-2D7VT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I7-01A-21R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
RPMI-8866	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OHPM-0326-SM-33HCA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950319
POGLUT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00499965
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
TANK	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-C9-A47Z-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYL3	MSigDB Cancer Gene Co-expression Modules	1.0	null
SKLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.44717
GTEX-PVOW-0126-SM-2XCFA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41805
increased keratinocyte proliferation	MGI Mouse Phenotype Associations 2023	1.0	null
ZC3H4	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10W-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Scleredema adultorum	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
DDX20	Pathway Commons Protein-Protein Interactions	1.0	null
RAD50	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K83902026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44769
ZC3HAV1	Pathway Commons Protein-Protein Interactions	1.0	null
CDK18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604847
PDPK1	Pathway Commons Protein-Protein Interactions	1.0	null
496100376_FWM_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.54536
Perturb_10216_KO_Csnk1a1/Trp53_ERP021472	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-12.9057
ITGB4	Pathway Commons Protein-Protein Interactions	1.0	null
GNL3	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10175786-Table4.XLSX-Sheet_1-GSE9750_AND_GSE63514_NOT_GSE7410_NOT_Ferrotosis_genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TMMY-1126-SM-4DXSX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893076
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
EIF3D	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRN-0126-SM-48TDM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19196
influence	GeneRIF Biological Term Annotations	1.0	null
AVPR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00621611
AK2	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_1290_KO_Lef1_SRP111197	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
CBX4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00477867
ALDH1B1	Pathway Commons Protein-Protein Interactions	1.0	null
SMCHD1	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2882-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU5F1	Pathway Commons Protein-Protein Interactions	1.0	null
NME2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00595775
Contact dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.884
KRT10	Pathway Commons Protein-Protein Interactions	1.0	null
Intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.667
LOVO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K42385001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76642
GTEX-QLQW-0226-SM-447BJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
HNRNPA2B1	Pathway Commons Protein-Protein Interactions	1.0	null
TFEC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519937
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03461
GTEX-U3ZN-1826-SM-4DXUY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
VPS35	Pathway Commons Protein-Protein Interactions	1.0	null
Ichthyosis vulgaris	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.116
BRD-K10358320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77474
GTEX-TMMY-1526-SM-4DXST	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
abnormality of fluid regulation	HPO Gene-Disease Associations	1.0	null
IPO7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K78747341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05935
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC9061835-41523_2022_425_MOESM1_ESM.xlsx-S3_Differential_GEX-Table-S3_Differential_expression_analysis_results_for_SOX10-high_versus_SOX10-low_TNBCs_from_the_TGCA_and_METABRIC_expression_datasets_SOX10	Rummagene Transcription Factor Associations 2026	1.0	null
SSBP1	Pathway Commons Protein-Protein Interactions	1.0	null
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9317
19192944-TableS4	GeneSigDB Published Gene Signatures	1.0	null
CFL1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-520g	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
SMAD4-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
dorsolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09038
Palmoplantar keratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.524
Acute Myeloid Leukemia_LAML_TCGA-AB-2944-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphocyte	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.157
hsa-miR-4672	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
CRCGN016_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66297
hsa-miR-4308	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
AIMP1	Pathway Commons Protein-Protein Interactions	1.0	null
extracellular vesicular exosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
exocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.318407
LSM2	Pathway Commons Protein-Protein Interactions	1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
MDAMB415	DepMap CRISPR Gene Dependency	1.0	2.91328
Cell envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.357
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13107
NUFIP2	Pathway Commons Protein-Protein Interactions	1.0	null
FLII	Pathway Commons Protein-Protein Interactions	1.0	null
FNIP1	Pathway Commons Protein-Protein Interactions	1.0	null
duodenum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.193367
dermal papilla	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.524771
SHMT1	Pathway Commons Protein-Protein Interactions	1.0	null
CPSF1	Pathway Commons Protein-Protein Interactions	1.0	null
CSF2RB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00658348
MRPL13	Pathway Commons Protein-Protein Interactions	1.0	null
DHX36	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XYKS-2126-SM-4E3IB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28012
FARSB	Pathway Commons Protein-Protein Interactions	1.0	null
Vohwinkel syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.007
MSH6	Pathway Commons Protein-Protein Interactions	1.0	null
EPN1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.03661
AP2A2	Pathway Commons Protein-Protein Interactions	1.0	null
SNU489	CCLE Cell Line Gene Expression Profiles	-1.0	-1.75968
PMC12271601-mmc2.xlsx-OUT_cells_03-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
IQSEC1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K77663497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36851
BRD-K16739515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05278
GSE207514,GSE207515_1_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MEMO1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K00505499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10685
BRD-K08442552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05814
WEE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00516071
Kidney Chromophobe_KICH_TCGA-KN-8422-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
16651409-SuppTable5	GeneSigDB Published Gene Signatures	1.0	null
PMC7709111__F5	PFOCR Pathway Figure Associations 2024	1.0	null
ASMT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00585767
tonsil	HPA Tissue Gene Expression Profiles	1.0	0.987877
HuO-3N1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.19839
MZ7-mel	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.76767
ACTN1	Pathway Commons Protein-Protein Interactions	1.0	null
BOC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00671457
Tongue epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.921
GTEX-TKQ1-1026-SM-4GICL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4237
BRD-K82126187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52886
Pavement epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.619
SCC25_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	4.19429
Lung adenocarcinoma_LUAD_TCGA-55-6968-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.657326
PMC8169803-mmc2.xlsx-KDM2B-GFP-Unnamed_1_KDM2B	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K83393282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08806
NCIH650	CCLE Cell Line Gene CNV Profiles	1.0	1.47302
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PMC7450072-41598_2020_71096_MOESM1_ESM.xlsx-Table3_SS_vs_AA_MP-Gene_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5876-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00851081
GTEX-R55E-0326-SM-48FD2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
COPA	Pathway Commons Protein-Protein Interactions	1.0	null
CRKL	Pathway Commons Protein-Protein Interactions	1.0	null
KRT76	Pathway Commons Protein-Protein Interactions	1.0	null
H2BFS	Pathway Commons Protein-Protein Interactions	1.0	null
LYAR	Pathway Commons Protein-Protein Interactions	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.525955
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K54881917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20306
Rhabdomyocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.685
TSSK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00796095
DMRT1	ChEA Transcription Factor Targets	1.0	null
H3C8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00672023
PRKCA	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7789679-13287_2020_2062_MOESM3_ESM.docx-2-Supplementary_Table_3_MSC_secretome_following_degenerative_CM_stimulation_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
ABTB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00670284
MARK3	Pathway Commons Protein-Protein Interactions	1.0	null
GPRC5A	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN008_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2876
BRD-K47962810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38063
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4531
HSPB1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K33637419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30149
FAM98A	Pathway Commons Protein-Protein Interactions	1.0	null
CSNK2A2	Pathway Commons Protein-Protein Interactions	1.0	null
telmisartan_rattus norvegicus_gpl4135_gse29445	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K93927229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22386
keratinocyte proliferation	GO Biological Process Annotations 2023	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LX-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K58607444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.053
GABARAPL1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K57167256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29802
TEFM	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S341-1826-SM-3K2AB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922786
MAP3K11	Pathway Commons Protein-Protein Interactions	1.0	null
ENO1	Pathway Commons Protein-Protein Interactions	1.0	null
HSPA5	Pathway Commons Protein-Protein Interactions	1.0	null
ERLIN1	Pathway Commons Protein-Protein Interactions	1.0	null
trans-Golgi network transport vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.762
GTEX-U3ZM-0326-SM-4DXUJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
MARS	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K19245310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12908
TR146	DepMap CRISPR Gene Dependency	1.0	3.60908
GTEX-XGQ4-0926-SM-4AT4U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
TNK1	Pathway Commons Protein-Protein Interactions	1.0	null
SNU-475	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.76851
KDM2B-26808549-CHIP-SEQ-REH-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
uterus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.351856
BRD-A39900448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15433
CCDC122	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00509844
Sweat gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.71
eccrine sweat gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.565631
ALDOC	Pathway Commons Protein-Protein Interactions	1.0	null
HIP1R	Pathway Commons Protein-Protein Interactions	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
BRD-K35960502_NICLOSAMIDE_NCIH2073_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K25638721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23304
GTEX-P4PQ-0126-SM-2S1NM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09335
CCBL2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K13566078_BMS-345541_MDAMB231_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RPS28	Pathway Commons Protein-Protein Interactions	1.0	null
AGO2	Pathway Commons Protein-Protein Interactions	1.0	null
LONP1	Pathway Commons Protein-Protein Interactions	1.0	null
ASPC1	DepMap CRISPR Gene Dependency	1.0	4.80808
RKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02664
Lung squamous cell carcinoma_LUSC_TCGA-18-3410-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IGSF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00503995
TK1	Pathway Commons Protein-Protein Interactions	1.0	null
CTNS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00655151
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.80563
extracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
GTEX-XGQ4-2426-SM-4AT55	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
Periodontium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.285
NEDD4	Pathway Commons Protein-Protein Interactions	1.0	null
keratinocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.26128
PHGDH	Pathway Commons Protein-Protein Interactions	1.0	null
RPL28	Pathway Commons Protein-Protein Interactions	1.0	null
MACROD1	Pathway Commons Protein-Protein Interactions	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7425-11A-01R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Wing	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.228
CRCGN008_HEPG2_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0764
Prostate adenocarcinoma_PRAD_TCGA-G9-6338-01A-12R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K00562490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06107
NEK1	Pathway Commons Protein-Protein Interactions	1.0	null
UPF1	Pathway Commons Protein-Protein Interactions	1.0	null
PIK3R2	Pathway Commons Protein-Protein Interactions	1.0	null
SKLMS1	DepMap CRISPR Gene Dependency	1.0	2.67265
CLTC	Pathway Commons Protein-Protein Interactions	1.0	null
JHOS-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K05181466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13292
CA14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99036
Wart	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.61
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.882236
acantholysis	HPO Gene-Disease Associations	1.0	null
BRD-K57127959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89871
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NME2	Pathway Commons Protein-Protein Interactions	1.0	null
sulfamerazine-3616	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYLA	DepMap CRISPR Gene Dependency	1.0	2.43639
RBBP6	Pathway Commons Protein-Protein Interactions	1.0	null
Tongue	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.95883
RPL6	Pathway Commons Protein-Protein Interactions	1.0	null
496100522_PCx_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.41973
Lung adenocarcinoma_LUAD_TCGA-62-8394-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YARS	Pathway Commons Protein-Protein Interactions	1.0	null
HUH1	CCLE Cell Line Gene CNV Profiles	1.0	1.39495
FOXK2	Pathway Commons Protein-Protein Interactions	1.0	null
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.65479
BRD-K64902833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44713
SFPQ	Pathway Commons Protein-Protein Interactions	1.0	null
SIGLEC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00848876
KRT81	Pathway Commons Protein-Protein Interactions	1.0	null
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.667
hsa-miR-4491	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Esophagus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Monilethrix	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.048
PKN2	Pathway Commons Protein-Protein Interactions	1.0	null
RAB10	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPDL	Pathway Commons Protein-Protein Interactions	1.0	null
Photoreceptor connecting cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.818
Ichthyosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.06
Autosomal Dominant Ichthyosis	DisGeNET Gene-Disease Associations	1.0	null
COV504	DepMap CRISPR Gene Dependency	1.0	5.41255
FUBP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PLRG1	Pathway Commons Protein-Protein Interactions	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.803961
CDC5L	Pathway Commons Protein-Protein Interactions	1.0	null
HDGF	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AY-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K38211037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11648
VDAC2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846967
small testis	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K57228212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7126
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.997267
59M	CCLE Cell Line Gene Expression Profiles	-1.0	-1.86781
GTEX-XBEC-1226-SM-4AT65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PECAPJ49	CCLE Cell Line Gene Expression Profiles	-1.0	-1.8246
TBC1D2B	Pathway Commons Protein-Protein Interactions	1.0	null
BFSP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00667763
CLTA	Pathway Commons Protein-Protein Interactions	1.0	null
Wound fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.527
ZNF354C	JASPAR Predicted Transcription Factor Targets	1.0	null
CORL311	CCLE Cell Line Gene Expression Profiles	1.0	3.40782
FER	Pathway Commons Protein-Protein Interactions	1.0	null
Cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
SEPT2	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-582-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
AML - Acute myeloid leukemia_Mononuclear Leukocyte_GSE2191	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.172974
Endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.717
RPL8	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K21695872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22084
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.063
TCERG1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K04238122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57865
epithelial cell migration	GO Biological Process Annotations 2023	1.0	null
GTEX-XAJ8-0826-SM-47JY6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87545
CD8A	MSigDB Cancer Gene Co-expression Modules	1.0	null
COLO-678	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.52377
PIGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583633
BRD-A71933035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75187
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830791
GTEX-S3XE-1726-SM-3K2AM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13932
GTEX-U3ZM-0226-SM-4DXTA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880233
H1F0	Pathway Commons Protein-Protein Interactions	1.0	null
GATA2	ChEA Transcription Factor Targets	1.0	null
BRD-K47998973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4487
MRPL12	Pathway Commons Protein-Protein Interactions	1.0	null
IGF2BP2	Pathway Commons Protein-Protein Interactions	1.0	null
epidermis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
12115547-Table4	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
CCR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00877914
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076895
BRD-K01240438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20548
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TUBB2A	Pathway Commons Protein-Protein Interactions	1.0	null
Epidermolysis bullosa simplex Dowling-Meara type	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.162
membrane-bounded vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
biological_process	GO Biological Process Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DGKI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00421288
BRD-K35897342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05494
cytoskeleton	GO Cellular Component Annotations 2015	1.0	null
autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.505739
SMC4-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SRPX	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K11013450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56851
skin inflammation	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K25907192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23212
Ichthyosis Bullosa of Siemens	CTD Gene-Disease Associations	1.0	2.88009
Mammary duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.919
BRD-K74512976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62981
BRD-K21584435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20467
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FEV	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7796
GTF2I	Pathway Commons Protein-Protein Interactions	1.0	null
FOXO3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00544592
Lung adenocarcinoma_LUAD_TCGA-55-7728-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIP	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-N7MS-2526-SM-2D7W3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
CD101	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00702474
BRD-A99687212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98169
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	52.7944
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.445805
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LOVO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1349
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SUIT2_PANCREAS	CCLE Cell Line Proteomics	1.0	2.10673
TUBB2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0056702
Sebaceous gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.656
HNRNPH1	Pathway Commons Protein-Protein Interactions	1.0	null
RPMI-8402	GDSC Cell Line Gene Expression Profiles	1.0	1.78716
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830791
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IX-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCCC1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A9DE-11A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate filament organization	GO Biological Process Annotations 2025	1.0	null
PABPN1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K81370109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7085
GTEX-XLM4-1026-SM-4AT51	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866198
RRBP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848785
ACACB	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U3ZH-0626-SM-4DXT3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
Idiopathic fibrosing alveolitis_Lung Tissue_GSE21369	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.97995
RPL36	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.79318
MYO18A	Pathway Commons Protein-Protein Interactions	1.0	null
Male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.55
small testis	IMPC Knockout Mouse Phenotypes	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-5122-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.935553
LYPLA1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K25718133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02502
GTEX-QDT8-0011-R2A-SM-32PKQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
Lupus erythematosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
RPL27	Pathway Commons Protein-Protein Interactions	1.0	null
X-linked ichthyosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.175
LMNA	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S7SE-0011-R5A-SM-2XCDA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914138
GSE212330_1_v_0_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PSMG2	Pathway Commons Protein-Protein Interactions	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
ERH	Pathway Commons Protein-Protein Interactions	1.0	null
GSE182680,GSE182683_0_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
icthyosis	GeneRIF Biological Term Annotations	1.0	null
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.080292
GSE218060_7_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K00223956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00689
PRKCD	Pathway Commons Protein-Protein Interactions	1.0	null
EZH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0057231
GTEX-SJXC-0126-SM-2XCFF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82605
SLC4A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00541451
S-117	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RBBP4	Pathway Commons Protein-Protein Interactions	1.0	null
SKG-IIIA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SMARCC2	Pathway Commons Protein-Protein Interactions	1.0	null
RPL37A	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q734-1926-SM-2I5EV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29833
SP3_01_290	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.66596
nucleus	GO Cellular Component Annotations 2023	1.0	null
cytoskeleton	GO Cellular Component Annotations 2025	1.0	null
gp5d	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.526
GTEX-SSA3-0126-SM-32QPU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5808
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3382
FHIT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0049673
CNN3	Pathway Commons Protein-Protein Interactions	1.0	null
CAP1	Pathway Commons Protein-Protein Interactions	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.094
WNT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0064101
GTEX-U3ZN-1226-SM-4DXUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
HBE1	Pathway Commons Protein-Protein Interactions	1.0	null
UBE2M	Pathway Commons Protein-Protein Interactions	1.0	null
NUAK1	Pathway Commons Protein-Protein Interactions	1.0	null
MTPN	Pathway Commons Protein-Protein Interactions	1.0	null
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PTEN	MSigDB Cancer Gene Co-expression Modules	1.0	null
etamsylate-4576	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9518
Gingival epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.936
RPS12	Pathway Commons Protein-Protein Interactions	1.0	null
Keloid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.768
cornified envelope	GO Cellular Component Annotations 2025	1.0	null
BRD-K28319429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04816
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T4-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC25A22	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583085
HEPG2	CCLE Cell Line Gene Expression Profiles	-1.0	-3.00495
ANKHD1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QV44-1926-SM-2S1RF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35905
BRD-K43674766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13475
SW620	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RBM39	Pathway Commons Protein-Protein Interactions	1.0	null
SK-MEL-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QDT8-0011-R7A-SM-32PKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
ARF5	Pathway Commons Protein-Protein Interactions	1.0	null
TBKBP1	Pathway Commons Protein-Protein Interactions	1.0	null
SEC23B	Pathway Commons Protein-Protein Interactions	1.0	null
OLA1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRK-0226-SM-3NB2G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65292
Blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-XGQ4-1226-SM-4AT67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
MMP8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00663089
EIF4A3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K81751970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57128
SNRPD1	Pathway Commons Protein-Protein Interactions	1.0	null
FTO	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4446-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
tooth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.104515
stratum basale	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.842447
GSE217541,GSE217543_0_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SIK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00936357
PPL	Pathway Commons Protein-Protein Interactions	1.0	null
QPCT	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XLM4-0008-SM-4AT4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
MPP2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TSE9-2526-SM-4DXUS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-WEY5-2326-SM-3GIKK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07476
MON	DepMap CRISPR Gene Dependency	1.0	4.08391
BRD-K26852477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51638
Adrenal gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.45
EEF2	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular non-membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
GSE142210_3_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PAX7	MSigDB Cancer Gene Co-expression Modules	1.0	null
H3K9me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-TSE9-0008-SM-4DXT8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
STX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0059446
BRD-K53639581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46514
CRCGN017_MCF10A.WT.HP_24H:G21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80605
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-QDVJ-0826-SM-48U1S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.91395
GTEX-XBED-1226-SM-4AT5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
CRCGN008_HEPG2_24H:I07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0553
DGAT2L7P	Pathway Commons Protein-Protein Interactions	1.0	null
Pure hair and nail ectodermal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.782
CCC5	DepMap CRISPR Gene Dependency	1.0	4.89597
Integument	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-QCQG-0426-SM-48U29	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849876
CDH4	MSigDB Cancer Gene Co-expression Modules	1.0	null
APOBEC3C	Pathway Commons Protein-Protein Interactions	1.0	null
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.815781
GTEX-XAJ8-1426-SM-47JYM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15051
STK3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K83816656_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pancreas	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.311
RPMI8402	CCLE Cell Line Gene Expression Profiles	1.0	1.85447
PLOD3	Pathway Commons Protein-Protein Interactions	1.0	null
Fibrosis	CTD Gene-Disease Associations	1.0	1.07696
GTEX-WOFL-0126-SM-3MJG2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988879
RAP1B	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.76425
fetus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069665
GPRC6A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00483586
Excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.517
Alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-QVJO-1826-SM-447C9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
H4C5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00849284
GTEX-QMR6-0011-R11A-SM-32PKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
Focal nonepidermolytic palmoplantar keratoderma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.103
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.656005
DHX9	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1	Rummagene Transcription Factor Associations 2026	1.0	null
TAF15	Pathway Commons Protein-Protein Interactions	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.449
GFI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00331315
epithelial-stromal TGFBI dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
Measles Chicago-1_6Hour_16492729_GSE980	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.74335
TIAM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0076573
MAGEA8	MSigDB Cancer Gene Co-expression Modules	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SRI	Pathway Commons Protein-Protein Interactions	1.0	null
ATP5O	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U4B1-0726-SM-4DXUA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
COLO-792	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CYP1A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00628167
SIGLEC10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570947
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065948
NB10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-RN64-0126-SM-2TC68	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18467
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.86991
ANAPC1	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH1385	CCLE Cell Line Gene CNV Profiles	1.0	1.37319
OGFOD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00528843
DDX41	Pathway Commons Protein-Protein Interactions	1.0	null
AU565	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.19909
Lung squamous cell carcinoma_LUSC_TCGA-68-8251-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE118077_1_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.22436
hsa-miR-4756-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BRD-K93726930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2196
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TM9SF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00409274
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.315974
BRD-K87617154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06141
GTEX-QV44-0926-SM-2S1RH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871716
CRCGN017_MCF10A.WT.HP_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.59445
HNRNPA3	Pathway Commons Protein-Protein Interactions	1.0	null
Corneocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.835
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900566
BRD-K51207618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12555
NUDT1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UTHO-0011-R5A-SM-3GIJD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888536
IRGQ	Pathway Commons Protein-Protein Interactions	1.0	null
icSARA deltaORF6_12Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.59026
KCIMOH1	DepMap CRISPR Gene Dependency	1.0	2.00549
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5465-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
epithelial cell proliferation	GO Biological Process Annotations 2015	1.0	null
GTEX-XMD1-0011-R5A-SM-4AT47	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843153
MYH10	Pathway Commons Protein-Protein Interactions	1.0	null
RPL23A	Pathway Commons Protein-Protein Interactions	1.0	null
GPI	Pathway Commons Protein-Protein Interactions	1.0	null
Blood microparticle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.816
GTEX-X4EO-2926-SM-4E3JH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1409
all	GWASdb SNP-Phenotype Associations	1.0	0.032537
PCM1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE131649_6_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphoid tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.633
Plasma membrane-derived chromatophore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.954
PMC7415402-oncotarget-11-2995-s004.xlsx-EWS-FLI1_Type_1_vs_Type_3-Gene_Symbol_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-XMD3-2326-SM-4AT5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853043
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33645
PRKCZ	Pathway Commons Protein-Protein Interactions	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
DDX1	Pathway Commons Protein-Protein Interactions	1.0	null
basal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.249257
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Weight Loss	CTD Gene-Disease Associations	1.0	1.20751
NDUFA5	Pathway Commons Protein-Protein Interactions	1.0	null
Hypotrichosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.33
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04316
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_42_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
SNRPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3201
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5EA-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
stratum corneum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.663555
GATA1-19941826-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GALC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00488624
Urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-Q2AH-0826-SM-48TZN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975046
ORC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00342247
PABPC1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CPSF7	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H358	COSMIC Cell Line Gene Mutation Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.194
YBX1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K54647996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00135
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.730739
ACACB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571801
Epidermolysis bullosa dystrophica	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.591
PMC7880379-aging-13-202285-s003.xlsx-DElncRNA_target-FEZF1_FEZF1	Rummagene Transcription Factor Associations 2026	1.0	null
NDUFS3	Pathway Commons Protein-Protein Interactions	1.0	null
PECAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00592179
GTEX-TSE9-2626-SM-4DXV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
RBM14	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K19712167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86296
P68-20966046-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
S100A11	Pathway Commons Protein-Protein Interactions	1.0	null
CBL	Pathway Commons Protein-Protein Interactions	1.0	null
SNU283	CCLE Cell Line Gene Expression Profiles	-1.0	-1.85705
TFAP4::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.4714
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.905996
polymeric cytoskeletal fiber	GO Cellular Component Annotations 2023	1.0	null
GJB6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00648651
BMF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00848013
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
MEL270	DepMap CRISPR Gene Dependency	1.0	6.66053
COX7A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00712112
BRD-K71253424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18558
Abnormal Blistering Of The Skin	DisGeNET Gene-Phenotype Associations	1.0	null
hypotrichosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.204593
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041603
Junctional zone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.985
prilocaine-3624	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.5924
RAC1	Pathway Commons Protein-Protein Interactions	1.0	null
Hypohidrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.473
BCL2L11	MSigDB Cancer Gene Co-expression Modules	1.0	null
Integumentary system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
EXOSC1	Pathway Commons Protein-Protein Interactions	1.0	null
GOLGA2	Pathway Commons Protein-Protein Interactions	1.0	null
riboflavin-2760	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ATF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5X1-2526-SM-3GILC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35654
ZC3HAV1L	Pathway Commons Protein-Protein Interactions	1.0	null
SLC2A1	Pathway Commons Protein-Protein Interactions	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.591337
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.07128
BRD-K59239976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10343
GTEX-OHPM-0126-SM-2YUN9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40025
Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K46065636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76625
IST1	Pathway Commons Protein-Protein Interactions	1.0	null
SNRNP40	Pathway Commons Protein-Protein Interactions	1.0	null
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.857501
Formation of the cornified envelope	Reactome Pathways 2024	1.0	null
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ACLY	Pathway Commons Protein-Protein Interactions	1.0	null
SNRPA	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15086
f1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.918
EB2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03329
GEMIN4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K21139023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45226
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.884226
hsa-miR-3138	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
BRD-K22093970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35561
primary motor cortex (area M1, area 4)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.946816
EIF4H	Pathway Commons Protein-Protein Interactions	1.0	null
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UJHI-1326-SM-4IHJO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854069
BRD-K05969019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14516
BRD-K95895516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20706
mammary paget's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.311377
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.902728
NUP155	Pathway Commons Protein-Protein Interactions	1.0	null
sweat gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.725685
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE164494_1_v_2_rab22a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR1A	Pathway Commons Protein-Protein Interactions	1.0	null
CILP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0061204
MRPS6	Pathway Commons Protein-Protein Interactions	1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-3731-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958045
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MAP1B	Pathway Commons Protein-Protein Interactions	1.0	null
ASNS	Pathway Commons Protein-Protein Interactions	1.0	null
GANAB	Pathway Commons Protein-Protein Interactions	1.0	null
cornea	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.22246
ALYREF	Pathway Commons Protein-Protein Interactions	1.0	null
GARS	Pathway Commons Protein-Protein Interactions	1.0	null
keratinization	GO Biological Process Annotations 2015	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1926
IL17RB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00548491
GTEX-QDVN-0226-SM-48TZ9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-S7SE-0011-R11A-SM-2XCDD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836726
Keratin filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.507
LN18	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.931392
TRAP1	Pathway Commons Protein-Protein Interactions	1.0	null
Leukocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.633
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
abnormal epidermal layer morphology	MPO Gene-Phenotype Associations	1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
ACVR2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00678653
KE-37	GDSC Cell Line Gene Expression Profiles	1.0	1.96018
STAT5B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PX3G-0726-SM-48TZT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.912403
Kidney Chromophobe_KICH_TCGA-KN-8426-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COV318	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.833009
increased tail pigmentation	MGI Mouse Phenotype Associations 2023	1.0	null
PDCD6	Pathway Commons Protein-Protein Interactions	1.0	null
RBM28	Pathway Commons Protein-Protein Interactions	1.0	null
ILF3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Secretory granule lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.914
SSRP1	Pathway Commons Protein-Protein Interactions	1.0	null
HIST1H1A	Pathway Commons Protein-Protein Interactions	1.0	null
epithelial cell migration	GO Biological Process Annotations 2025	1.0	null
NTPCR	Pathway Commons Protein-Protein Interactions	1.0	null
abnormality of skin morphology	HPO Gene-Disease Associations	1.0	null
GTEX-Q2AH-1626-SM-3GAF8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83693
BRD-K56415410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24153
GTEX-QLQ7-1626-SM-2S1R8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30258
Appendix	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55362
GTEX-PX3G-2026-SM-48U1H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926353
UBAP2L	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QDT8-0226-SM-32PL4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
MOLT-16	GDSC Cell Line Gene Expression Profiles	1.0	1.56071
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_4_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.55
GTEX-U3ZM-1526-SM-3DB9D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19626
thick epidermis	MPO Gene-Phenotype Associations	1.0	null
WDR45B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
RBM4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K31608682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06986
BRD-K01922054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12989
BRD-K15523383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11252
HMGCS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0040248
abnormal tail morphology	MPO Gene-Phenotype Associations	1.0	null
CRCGN014_HEPG2_24H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24623
LAMA84	CCLE Cell Line Gene Expression Profiles	1.0	1.60724
ATRIP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00530171
GTEX-WZTO-0126-SM-3NM95	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69375
NUDT16L1	Pathway Commons Protein-Protein Interactions	1.0	null
SMC1A	Pathway Commons Protein-Protein Interactions	1.0	null
TANK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00812837
RPS6KA6	Pathway Commons Protein-Protein Interactions	1.0	null
HSPA9	Pathway Commons Protein-Protein Interactions	1.0	null
DAP3	Pathway Commons Protein-Protein Interactions	1.0	null
fallopian tube	GTEx Tissue Gene Expression Profiles	-1.0	-1.25248
GSE229914_1_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
F8	Pathway Commons Protein-Protein Interactions	1.0	null
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kindler syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.428
Sarcoma_SARC_TCGA-DX-A2J4-01A-32R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39247583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24988
SAFB2	Pathway Commons Protein-Protein Interactions	1.0	null
oral mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.661116
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
OCT4-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
positive regulation of epidermis development	GO Biological Process Annotations 2023	1.0	null
epithelial cell migration	GO Biological Process Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XD-01A-22R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
thorax	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058969
MAPK8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00680009
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053008
GTEX-SNOS-0226-SM-32PLR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837191
BRD-K13792178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3525
keratinocyte migration	GO Biological Process Annotations 2015	1.0	null
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878562
ACOT13	Pathway Commons Protein-Protein Interactions	1.0	null
Hypodermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.02
PSMB5	Pathway Commons Protein-Protein Interactions	1.0	null
SPI1	ENCODE Transcription Factor Targets	1.0	null
NOP58	Pathway Commons Protein-Protein Interactions	1.0	null
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26674
Electric organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.702
ACTR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00705171
ELAVL1	Pathway Commons Protein-Protein Interactions	1.0	null
MELK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00334401
intracellular non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K75067815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1513
CDC42	Pathway Commons Protein-Protein Interactions	1.0	null
HOXA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00422782
RUNX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7644
GTEX-RU72-0926-SM-2TF6B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33514
RPL12	Pathway Commons Protein-Protein Interactions	1.0	null
ADCY3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00437214
SRPK1	Pathway Commons Protein-Protein Interactions	1.0	null
Hair follicle dermal papilla cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.189
organelle	GO Cellular Component Annotations 2015	1.0	null
GTEX-Q2AH-1126-SM-48TZM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925606
RAB11FIP5	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QLQW-1426-SM-2S1QU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.989026
EXOSC4	Pathway Commons Protein-Protein Interactions	1.0	null
sweat	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.33046
GTEX-UJHI-1526-SM-3DB99	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65487
GTEX-T2IS-1926-SM-4DM74	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977904
WDR77	Pathway Commons Protein-Protein Interactions	1.0	null
hacat cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.256902
GTEX-XOTO-0726-SM-4B659	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51477
Tail fin cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.986
Necrosis	CTD Gene-Disease Associations	1.0	1.24275
ATG16L1	Pathway Commons Protein-Protein Interactions	1.0	null
VDAC1	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreas	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.42353
PPP2R1A	Pathway Commons Protein-Protein Interactions	1.0	null
APRT	Pathway Commons Protein-Protein Interactions	1.0	null
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.252261
Peeling skin syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
CPSF6	Pathway Commons Protein-Protein Interactions	1.0	null
Polymeric cytoskeletal fiber	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
RUSC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00639661
BRD-K66590796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74688
PNP	Pathway Commons Protein-Protein Interactions	1.0	null
496100369_PCx_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.69231
RPL11	Pathway Commons Protein-Protein Interactions	1.0	null
EDN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0037268
Focal or diffuse nonepidermolytic palmoplantar keratoderma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.353
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1737
SLC3A2	Pathway Commons Protein-Protein Interactions	1.0	null
IFI44L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00617959
BRD-K61206648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08039
ABCG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00603138
epidermolytic hyperkeratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	2.40209
MRPL19	Pathway Commons Protein-Protein Interactions	1.0	null
SNRPA1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K13122423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93615
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RFC1	Pathway Commons Protein-Protein Interactions	1.0	null
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.869966
Adrenocortical carcinoma_ACC_TCGA-OR-A5JL-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.316224
intermediate filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.26868
GTEX-XUW1-0426-SM-4BOOT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22821
mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.625061
GAR1	Pathway Commons Protein-Protein Interactions	1.0	null
NR4A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0064947
DDR1	Pathway Commons Protein-Protein Interactions	1.0	null
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4371
dydrogesterone-2811	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DOCK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00628633
MSR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00629764
superficial	GeneRIF Biological Term Annotations	1.0	null
GSE164494_1_v_2_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ADGRE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00615662
RPL32	Pathway Commons Protein-Protein Interactions	1.0	null
extracellular organelle	GO Cellular Component Annotations 2015	1.0	null
JURLMK1	CCLE Cell Line Gene Expression Profiles	1.0	1.79106
BRCA1	MSigDB Cancer Gene Co-expression Modules	1.0	null
ERF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7749
Bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.593
KPNA2	Pathway Commons Protein-Protein Interactions	1.0	null
EIF5A	Pathway Commons Protein-Protein Interactions	1.0	null
MCM5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K26108750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35953
GSE184892_0_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
SRSF3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K46970272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56738
H3K27me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0033
EFO21	DepMap CRISPR Gene Dependency	1.0	2.68395
non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
PKM	Pathway Commons Protein-Protein Interactions	1.0	null
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
SF3B4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QXCU-0926-SM-48FEP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
YY1	ChEA Transcription Factor Targets	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.25799
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
PF382	CCLE Cell Line Gene Expression Profiles	1.0	2.53979
ALDOA	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965452
MYCBP2	Pathway Commons Protein-Protein Interactions	1.0	null
HCC1833	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67459
GTEX-OHPL-0126-SM-2HMJ7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.646
primary motor cortex (area M1, area 4)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23828
BRD-K12312755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4616
vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Nonepidermolytic palmoplantar keratoderma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.738
DENND1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00503339
Perturb_16514_KD_Pou2f3_SRP343255	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.6657
epidermolysis bullosa	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.944521
GTEX-WHSB-1326-SM-3LK6W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23321
C14orf166	Pathway Commons Protein-Protein Interactions	1.0	null
CGTHW1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.8586
extracellular vesicle	GO Cellular Component Annotations 2015	1.0	null
ACTB	Pathway Commons Protein-Protein Interactions	1.0	null
Gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.5
Leaf epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.19
intermediate filament	GO Cellular Component Annotations 2015	1.0	null
IQCB1	Pathway Commons Protein-Protein Interactions	1.0	null
SRRM2	Pathway Commons Protein-Protein Interactions	1.0	null
muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.174634
huH-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.24954
BRD-K11419664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17344
Lassa Fever Virus_24hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.8849
interleukin-20 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.58
CHD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
oral epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.333396
KANK2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE218060_2_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
RDX	Pathway Commons Protein-Protein Interactions	1.0	null
RCN2	Pathway Commons Protein-Protein Interactions	1.0	null
ME1	CCLE Cell Line Gene Expression Profiles	1.0	1.56551
ME2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00387851
DCLK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00473538
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.83496
CBX6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0052902
GTEX-QDVN-0008-SM-48U2D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872809
keratin filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.1245
Telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
MED13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00674758
abnormality of the kidney	GWASdb SNP-Phenotype Associations	1.0	0.125671
RPS18	Pathway Commons Protein-Protein Interactions	1.0	null
RAB11B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S7SE-0126-SM-2XCD5	GTEx Tissue Sample Gene Expression Profiles	1.0	3.12521
BRD-K46609723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82136
PSMB1	Pathway Commons Protein-Protein Interactions	1.0	null
Intermediate filament cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
EZH2	ENCODE Transcription Factor Targets	1.0	null
SERPINE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00717775
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.428
PRPH	Pathway Commons Protein-Protein Interactions	1.0	null
urinary system disease	GWASdb SNP-Disease Associations	1.0	0.178613
Electrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.974
PGAM5	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QDVJ-1726-SM-2I5FX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.07926
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
SERPINB13	Pathway Commons Protein-Protein Interactions	1.0	null
Penis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.303
SERPINH1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TYMS	Pathway Commons Protein-Protein Interactions	1.0	null
shoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076593
cytosol	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-S4UY-0126-SM-3K2BB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37048
EIF5B	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7415402-oncotarget-11-2995-s004.xlsx-EWS-FLI1_Type_2_vs_Type_3-Gene_Symbol_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4486
Groin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
peptide cross-linking	GO Biological Process Annotations 2023	1.0	null
Keratinocyte_Epidermis_Human	CellMarker Gene-Cell Type Associations	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.700863
Cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
HNRNPM	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S95S-0008-SM-4AT5M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PRTN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00595059
Apocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.146
GTEX-XXEK-1626-SM-4BRUZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06858
MRPS22	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6538
PPT1	Pathway Commons Protein-Protein Interactions	1.0	null
PRDX4	Pathway Commons Protein-Protein Interactions	1.0	null
NBR1	Pathway Commons Protein-Protein Interactions	1.0	null
Posterior polymorphous corneal dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
Photoreceptor distal connecting cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.846
A4FUK	CCLE Cell Line Gene CNV Profiles	1.0	2.35439
CRCGN015_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56865
KMS34	CCLE Cell Line Gene CNV Profiles	1.0	1.65852
breast adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.192971
Autosomal recessive congenital ichthyosis 4A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.322
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.998792
BRD-K21662756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.47887
H3K27me3_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q734-1626-SM-48U1B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
SW948	DepMap CRISPR Gene Dependency	1.0	2.4167
BBS9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00708249
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A5ZZ-01A-31R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
acanthosis	MGI Mouse Phenotype Associations 2023	1.0	null
(+)-isoprenaline-5009	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A704	CCLE Cell Line Gene CNV Profiles	1.0	1.43752
TMEM216	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551845
PPP3CB	Pathway Commons Protein-Protein Interactions	1.0	null
FOXA1-25552417-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
FURIN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00587748
Large intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.667
BRD-K92428232_GSK-461364_MCF7_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTSE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00567638
nerve	GTEx Tissue Gene Expression Profiles	1.0	0.957599
WBP2	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1838	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-X261-0126-SM-3NMD6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22143
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.98755
GTEX-X8HC-0626-SM-4E3HQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00935
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05548
BRD-K96637144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28317
Sweat gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
PFKP	Pathway Commons Protein-Protein Interactions	1.0	null
HSD17B4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K21866464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26546
GTEX-XGQ4-0626-SM-4AT56	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
demeclocycline-3604	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A19500257_geldanamycin_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Keratinization	Reactome Pathways 2024	1.0	null
NIP7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K87209752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58298
CAMK2G	Pathway Commons Protein-Protein Interactions	1.0	null
ALVA31	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.16066
BRD-K35472285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14335
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.24647
PSMB4	Pathway Commons Protein-Protein Interactions	1.0	null
MRPS23	Pathway Commons Protein-Protein Interactions	1.0	null
HSPG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620343
polycystic kidney	IMPC Knockout Mouse Phenotypes	1.0	null
cheek	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.292079
dark foot pads	MPO Gene-Phenotype Associations	1.0	null
orthokeratosis	MGI Mouse Phenotype Associations 2023	1.0	null
growth/size/body phenotype	MPO Gene-Phenotype Associations	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.14476
Autosomal recessive congenital ichthyosis 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.314
NEDD8	Pathway Commons Protein-Protein Interactions	1.0	null
B4GALT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00673901
HCC1500	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.756508
RBM34	Pathway Commons Protein-Protein Interactions	1.0	null
SUPT3H	MSigDB Cancer Gene Co-expression Modules	1.0	null
GTEX-XGQ4-2226-SM-4AT4Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881233
647-V	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.10767
ARL3	MSigDB Cancer Gene Co-expression Modules	1.0	null
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3478
furazolidone-3358	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CLINT1	Pathway Commons Protein-Protein Interactions	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900566
Bloch-Sulzberger syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.352
MRPS11	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K57026098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59347
cyproterone-6124	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K21982562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41095
Steatocystoma multiplex	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.051
KRT19	Pathway Commons Protein-Protein Interactions	1.0	null
Autoimmune disease of skin and connective tissue	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.98
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13107
SKRC20	CCLE Cell Line Gene Expression Profiles	-1.0	-2.36697
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	1.0	1.3591
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
MONO-MAC-6	GDSC Cell Line Gene Expression Profiles	-1.0	-3.06311
E2F1-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WL46-0126-SM-3TW8I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940635
KIF2C	Pathway Commons Protein-Protein Interactions	1.0	null
KDELR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0088819
GTEX-U8T8-0126-SM-3DB94	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95902
CEACAM7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00652129
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.09047
CALR	Pathway Commons Protein-Protein Interactions	1.0	null
GART	Pathway Commons Protein-Protein Interactions	1.0	null
CUL9	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QCQG-1626-SM-48U26	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
BRD-K07368164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07828
GTEX-PLZ6-1426-SM-2S1OQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2445
GSK3A	Pathway Commons Protein-Protein Interactions	1.0	null
RPN1	Pathway Commons Protein-Protein Interactions	1.0	null
Head	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.533
FAM91A1	Pathway Commons Protein-Protein Interactions	1.0	null
Stratum corneum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.275
SRSF1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UPIC-1426-SM-4IHLQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875736
MVP	Pathway Commons Protein-Protein Interactions	1.0	null
butyl hydroxybenzoate-5245	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XBEW-1426-SM-4AT4J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-XBED-2426-SM-4AT4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.857501
HSPA1B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RWSA-0126-SM-2XCBB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.32976
BRD-K95591629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.54411
H3K4me1_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.22048
GTEX-O5YT-0526-SM-32PK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
BRD-K92022897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10428
KRTAP4-11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00620791
GTEX-TMMY-1726-SM-4DXTD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-S3XE-0008-SM-3NM8O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933895
HNRNPM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00527097
BRD-K98320707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99052
monilethrix	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.46407
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
PMC3568013-1471-2105-13-128-S5.xls-NME2-Unnamed_4_NME2	Rummagene Transcription Factor Associations 2026	1.0	null
Developmental Biology	Reactome Pathways 2024	1.0	null
CAOV-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.852
BRD-K39074860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00175
demecarium bromide-5795	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K73880067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18606
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4815-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
protein modification process	GO Biological Process Annotations 2025	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-SIU8-0126-SM-2XCDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12868
EEF1E1	Pathway Commons Protein-Protein Interactions	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JC-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RNOR-0126-SM-2TF57	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82107
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.878867
MCM7	Pathway Commons Protein-Protein Interactions	1.0	null
PRPF19	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TML8-1926-SM-32QOS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96842
RAB15	Pathway Commons Protein-Protein Interactions	1.0	null
keratinocyte	GeneRIF Biological Term Annotations	1.0	null
intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
APOC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00940677
AGL	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K21672423_7611062_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.621804
BRD-K10505056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08163
COPB2	Pathway Commons Protein-Protein Interactions	1.0	null
end stage renal failure	GWASdb SNP-Disease Associations	1.0	0.647686
PSMC6	Pathway Commons Protein-Protein Interactions	1.0	null
PGAM2	Pathway Commons Protein-Protein Interactions	1.0	null
HPAFII	CCLE Cell Line Gene CNV Profiles	1.0	1.74598
GTEX-XQ3S-1426-SM-4BOPR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12392
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00716
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70648
cytoskeletal part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.06347
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.452
Autosomal recessive congenital ichthyosis 4B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.932
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NONO	Pathway Commons Protein-Protein Interactions	1.0	null
LRRC59	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K02337960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94469
TFDP2	MSigDB Cancer Gene Co-expression Modules	1.0	null
PDCD6IP	Pathway Commons Protein-Protein Interactions	1.0	null
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.29043
enlarged kidney	IMPC Knockout Mouse Phenotypes	1.0	null
securinine-2729	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8419-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03094
AKR7A2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K20984459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45596
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02508
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.55814
SARC9371	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Type II polyketide synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.919
Langerhans cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.235
FDFT1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33714
NOS2	MSigDB Cancer Gene Co-expression Modules	1.0	null
NCI-H2135	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.882353
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
DHX16	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K62833556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06963
CAND1	Pathway Commons Protein-Protein Interactions	1.0	null
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-TMMY-1226-SM-4DXT6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
OCUB-M	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.36837
ATG7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K83475223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22113
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.72
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4827-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLIRP	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F1-17053090-MCF7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
Vagina	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN011_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2101
regulation of epidermis development	GO Biological Process Annotations 2023	1.0	null
DDX18	Pathway Commons Protein-Protein Interactions	1.0	null
YY1-22570637-MALME-3M-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
EZR	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UPJH-0226-SM-3GADV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18354
GABARAPL2	Pathway Commons Protein-Protein Interactions	1.0	null
RPS10	Pathway Commons Protein-Protein Interactions	1.0	null
Allergic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.691
ACTA2	Pathway Commons Protein-Protein Interactions	1.0	null
DLAT	Pathway Commons Protein-Protein Interactions	1.0	null
Bullous skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.034
ITGA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00946023
Gingival fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.528
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7968
vagina	GTEx Tissue Gene Expression Profiles	1.0	1.13606
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
extracellular space	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BUB3	Pathway Commons Protein-Protein Interactions	1.0	null
RAB35	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K63856509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49342
GTEX-QCQG-0726-SM-48U1Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CENPJ	Pathway Commons Protein-Protein Interactions	1.0	null
CSNK2A1	Pathway Commons Protein-Protein Interactions	1.0	null
RPS27L	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K23467057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05033
SET	Pathway Commons Protein-Protein Interactions	1.0	null
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
LRRC15	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-7660-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BCL2L2-PABPN1	Pathway Commons Protein-Protein Interactions	1.0	null
SLAIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00540216
thickened skin	HPO Gene-Disease Associations	1.0	null
HIST1H2BL	Pathway Commons Protein-Protein Interactions	1.0	null
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068144
SW480_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	3.21631
MCM3	Pathway Commons Protein-Protein Interactions	1.0	null
TMPO	Pathway Commons Protein-Protein Interactions	1.0	null
RPL17	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XUZC-1726-SM-4BRWS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50227
gp2d	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.66
Cornified envelope formation	KEGG Pathways 2026	1.0	null
GTEX-WY7C-2326-SM-3NB2U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2535
thin skin	HPO Gene-Disease Associations	1.0	null
PSMC3	Pathway Commons Protein-Protein Interactions	1.0	null
MBNL1	Pathway Commons Protein-Protein Interactions	1.0	null
juxtaglomerular cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.02513
ATP2A2	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45V-01A-21R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PCK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00708181
PSMB3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Periderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.854
Foot sole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.936
hsa-miR-4697-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
KRT1	Pathway Commons Protein-Protein Interactions	1.0	null
ST13	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K37961770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19675
Inflammation	CTD Gene-Disease Associations	1.0	1.15089
JUN	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U4B1-1226-SM-4DXT7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
Acne	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
BRD-K71109636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45732
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
GTEX-WYVS-2126-SM-3NMA3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56312
SCRIB	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.17563
Sarcoma_SARC_TCGA-QQ-A5VD-01A-21R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
G6PD	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897399
RCC1	Pathway Commons Protein-Protein Interactions	1.0	null
MDA-MB-175-VII	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-U3ZH-1926-SM-4DXTR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
secretory cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.260945
mode of inheritance	HPO Gene-Disease Associations	1.0	null
496100383_HIP_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.42251
SLC25A6	Pathway Commons Protein-Protein Interactions	1.0	null
RSU1	Pathway Commons Protein-Protein Interactions	1.0	null
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31896
GTEX-XLM4-0011-R8A-SM-4AT44	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860026
BRD-K75074041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19804
nipple	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.486326
SIPA1	Pathway Commons Protein-Protein Interactions	1.0	null
NUP88	Pathway Commons Protein-Protein Interactions	1.0	null
Liver	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.217
ACSM3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QDT8-0011-R6A-SM-32PKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
SFN	Pathway Commons Protein-Protein Interactions	1.0	null
CCR7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571323
Skin carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
TP53BP1	Pathway Commons Protein-Protein Interactions	1.0	null
MDAMB134VI	CCLE Cell Line Gene CNV Profiles	1.0	1.55536
breast carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.083698
lichen disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.414276
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.963129
KRT17	Pathway Commons Protein-Protein Interactions	1.0	null
FUBP3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K46588240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01346
SP140L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93414
GTEX-S7SF-0226-SM-3K2BI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932719
CORO1C	Pathway Commons Protein-Protein Interactions	1.0	null
SRSF10	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K28247259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29601
OBSL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00891522
Intermediate filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.049
NCIH1623	CCLE Cell Line Gene CNV Profiles	1.0	1.98788
GTEX-R55D-1226-SM-48FE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84023
extracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CAPRIN1	Pathway Commons Protein-Protein Interactions	1.0	null
abnormality of the urinary system physiology	GWASdb SNP-Phenotype Associations	1.0	0.207529
MDH2	Pathway Commons Protein-Protein Interactions	1.0	null
prenylamine-5489	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ITGA5	Pathway Commons Protein-Protein Interactions	1.0	null
SNRNP200	Pathway Commons Protein-Protein Interactions	1.0	null
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26447
eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056468
APOBR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620623
RPL5	Pathway Commons Protein-Protein Interactions	1.0	null
COPB1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K44141416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37156
GTEX-OIZG-0726-SM-33HBL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.71039
KG1	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21047
SRSF9	Pathway Commons Protein-Protein Interactions	1.0	null
GMPPA	Pathway Commons Protein-Protein Interactions	1.0	null
abnormality of the integument	HPO Gene-Disease Associations	1.0	null
TMED2	Pathway Commons Protein-Protein Interactions	1.0	null
corneal dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.542767
RBM4B	Pathway Commons Protein-Protein Interactions	1.0	null
DDB1	Pathway Commons Protein-Protein Interactions	1.0	null
DYNC1H1	Pathway Commons Protein-Protein Interactions	1.0	null
NCOR1-26117541-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Extracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
intermediate filament cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.26868
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.828652
BRD-K35960502_NICLOSAMIDE_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EGFR	Pathway Commons Protein-Protein Interactions	1.0	null
NAP1L1	Pathway Commons Protein-Protein Interactions	1.0	null
S100A7	Pathway Commons Protein-Protein Interactions	1.0	null
Periodontitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.192
GTEX-XOTO-2126-SM-4B64U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954033
STXBP3	Pathway Commons Protein-Protein Interactions	1.0	null
OAZ2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00525662
RAP2B	Pathway Commons Protein-Protein Interactions	1.0	null
LGALS1	Pathway Commons Protein-Protein Interactions	1.0	null
BAG4	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4713-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Autosomal recessive congenital ichthyosis 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.423
extracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.057922
LASP1	Pathway Commons Protein-Protein Interactions	1.0	null
BCL6-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915736
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
SDHB	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN011_HEPG2_24H:J12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.453
HIST1H2BJ	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9643473-Table1.xls-MAF_0_005-HGVS_gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
clorsulon-1735	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X638-0126-SM-47JZ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57765
NKRF	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K18149487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12622
CTSH	Pathway Commons Protein-Protein Interactions	1.0	null
KRT4	Pathway Commons Protein-Protein Interactions	1.0	null
LCMT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0066567
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A94W-01A-12R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K28535931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17389
RANBP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K32535831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47381
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.655
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SDCBP	Pathway Commons Protein-Protein Interactions	1.0	null
SLC7A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00605794
Leukocyte	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CAMK4	MSigDB Cancer Gene Co-expression Modules	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDVN-2026-SM-3GAEP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00692
kinetin-6813	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LS-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Colon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.333
BGC823	CCLE Cell Line Gene CNV Profiles	1.0	1.3985
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.35763
STRBP	Pathway Commons Protein-Protein Interactions	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
PACS1	Pathway Commons Protein-Protein Interactions	1.0	null
MAP4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K54100199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34799
GTEX-XBEW-0226-SM-4AT6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841623
Sense organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.533
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PAFAH1B3	Pathway Commons Protein-Protein Interactions	1.0	null
RCBTB1	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
RECQL4	Pathway Commons Protein-Protein Interactions	1.0	null
PYGL	Pathway Commons Protein-Protein Interactions	1.0	null
SMARCB1	Pathway Commons Protein-Protein Interactions	1.0	null
CDK1	Pathway Commons Protein-Protein Interactions	1.0	null
CNOT1	Pathway Commons Protein-Protein Interactions	1.0	null
XPO1	Pathway Commons Protein-Protein Interactions	1.0	null
AZGP1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_1_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
C-75-6394	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.86991
PSMA1	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-7774-01A-21R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPS20	Pathway Commons Protein-Protein Interactions	1.0	null
RBM12	Pathway Commons Protein-Protein Interactions	1.0	null
Duodenal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.921
NACA	Pathway Commons Protein-Protein Interactions	1.0	null
LDHB	Pathway Commons Protein-Protein Interactions	1.0	null
RT112	DepMap CRISPR Gene Dependency	1.0	3.40518
GAPDH	Pathway Commons Protein-Protein Interactions	1.0	null
CSRP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00505829
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07373
hard palate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.732596
GTEX-SNMC-1226-SM-2XCFP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74065
TACR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00535349
SK-HEP-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.58635
ANKFY1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PVOW-2626-SM-32PL8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
BRD-K61315077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20702
Secondary Malignant Neoplasm Of Lymph Node	DisGeNET Gene-Disease Associations	1.0	null
BRD-K80483148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71937
KRT13	Pathway Commons Protein-Protein Interactions	1.0	null
UMUC1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.88887
Eye	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.533
ATP5A1	Pathway Commons Protein-Protein Interactions	1.0	null
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066045
serine-type peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.198
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.80846
PARP1	Pathway Commons Protein-Protein Interactions	1.0	null
PMM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0057609
ANP32B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K33705415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40708
GTEX-UPK5-0326-SM-3GAF3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961887
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33399
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2884
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06059
palmoplantar keratoderma	HPO Gene-Disease Associations	1.0	null
LSM12	Pathway Commons Protein-Protein Interactions	1.0	null
XRN2	Pathway Commons Protein-Protein Interactions	1.0	null
Hematopoietic cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K54660148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16213
hair follicle inner root sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.03039
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BE-13	GDSC Cell Line Gene Expression Profiles	1.0	1.61697
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.90178
congenital bullous ichthyosiform erythroderma	HPO Gene-Disease Associations	1.0	null
BRD-K74978191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11325
Cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
CRCGN008_HEPG2_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0888
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.895
MLLT4	Pathway Commons Protein-Protein Interactions	1.0	null
DCD	Pathway Commons Protein-Protein Interactions	1.0	null
MMP14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00770892
496100332_HIP_possible Alzheimer's disease_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.12064
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.57008
GTEX-QDT8-0011-R1A-SM-32PKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PMC11769652-EHF2-12-250-s001.xlsx-Sheet1-ZEB1_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
ABCD3	Pathway Commons Protein-Protein Interactions	1.0	null
FKBP4	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7724-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-O5YT-0226-SM-32PK5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
hsa-miR-4755-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GTEX-V1D1-0626-SM-4JBHN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880174
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060766
BRD-K25081034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35189
keratin filament	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
tonsil_8e1	HPA Tissue Sample Gene Expression Profiles	1.0	0.982815
TP63	ChEA Transcription Factor Targets	1.0	null
skin epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.2922
Vaginal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.808
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.86991
Congenital Reticular Ichthyosiform Erythroderma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K88441035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2207
Prostate adenocarcinoma_PRAD_TCGA-V1-A8MF-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VN-A88N-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
golgi apparatus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
TRPV2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00630204
Epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.5
GSE131649_2_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TFAP2A	ChEA Transcription Factor Targets	1.0	null
GTEX-UPIC-0226-SM-3GADO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887203
gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.052697
Lymphoid tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
CAMKK2	Pathway Commons Protein-Protein Interactions	1.0	null
CSNK2B	Pathway Commons Protein-Protein Interactions	1.0	null
Naxos disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
LASV_FML29_8hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.82068
BRD-K83832060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07672
Golgi cisterna membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.64
DARS	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S32W-2526-SM-2XCB8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968649
769-P	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.16192
NME9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0054396
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.826108
ITGB7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00697784
11289099-Table2	GeneSigDB Published Gene Signatures	1.0	null
MAT2A	Pathway Commons Protein-Protein Interactions	1.0	null
amitriptyline-167	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ITGB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00745152
HSPA1L	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XE-01A-12R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal skin coloration	MPO Gene-Phenotype Associations	1.0	null
TUBB4B	Pathway Commons Protein-Protein Interactions	1.0	null
DALRD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.010059
GTEX-WYBS-0626-SM-3NMAS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20513
autosomal dominant inheritance	HPO Gene-Disease Associations	1.0	null
LYZ	Pathway Commons Protein-Protein Interactions	1.0	null
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.74284
LAMB2	Pathway Commons Protein-Protein Interactions	1.0	null
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.950404
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.93224
GYS1	Pathway Commons Protein-Protein Interactions	1.0	null
HPAC	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.31698
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-U3ZN-0826-SM-4DXSZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
Lichen disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
GTEX-TMMY-1626-SM-4DXTY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-XMD1-0011-R8A-SM-4AT48	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
localized skin lesion	HPO Gene-Disease Associations	1.0	null
SNRPE	Pathway Commons Protein-Protein Interactions	1.0	null
Keratin filament	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
GTEX-TSE9-3126-SM-4DXSY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.3494
MRE11A	Pathway Commons Protein-Protein Interactions	1.0	null
LY-294002-5587	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K43390655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05071
EPDR1	Pathway Commons Protein-Protein Interactions	1.0	null
KM-H2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-TML8-0008-SM-4DXUI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
MAPK1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TML8-1326-SM-4DXTO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
BRD-K67211407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3561
abnormal ear morphology	MPO Gene-Phenotype Associations	1.0	null
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.83384
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07608
Liver hepatocellular carcinoma_LIHC_TCGA-MR-A8JO-01A-12R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Psoriasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.99
GTEX-PWO3-1526-SM-48TCM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06528
ACHN	CCLE Cell Line Gene CNV Profiles	1.0	1.67112
BRD-K08533345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40331
PSMB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00617866
ACTC1	Pathway Commons Protein-Protein Interactions	1.0	null
cell communication	KEGG Pathways	1.0	null
abnormal ear pigmentation	MPO Gene-Phenotype Associations	1.0	null
GTEX-WYJK-1626-SM-3NM9J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950824
vesiculobullous skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.932898
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29598
NFYA	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-U3ZN-2026-SM-4DXUC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
VARS	Pathway Commons Protein-Protein Interactions	1.0	null
oral	GeneRIF Biological Term Annotations	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
mammary gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085326
YWHAZ	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PW2O-1426-SM-48TCD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00374
GSK3B	Pathway Commons Protein-Protein Interactions	1.0	null
SEC23A	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-C9-A480-01A-12R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K61440521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12337
HRNR	Pathway Commons Protein-Protein Interactions	1.0	null
GNB1L	Pathway Commons Protein-Protein Interactions	1.0	null
IGF1_OE_GDS3484_538_human_MCF-7	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
WBSCR22	MSigDB Cancer Gene Co-expression Modules	1.0	null
External male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.297
GTEX-P4PP-0126-SM-3LK69	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05601
KLB	Pathway Commons Protein-Protein Interactions	1.0	null
SDHA	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K09996575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1155
KRT71	Pathway Commons Protein-Protein Interactions	1.0	null
KCNJ15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00469438
BRD-K24929039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32955
TRIM28	Pathway Commons Protein-Protein Interactions	1.0	null
Cuticle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.121
Oral epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.383
SEC24C	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OOBK-2626-SM-2HMKY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827322
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
ASPM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00721883
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pirlindole-5497	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF382	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.5397
PRKCSH	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K00300115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23014
NECAP2	Pathway Commons Protein-Protein Interactions	1.0	null
COPE	Pathway Commons Protein-Protein Interactions	1.0	null
CDA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00652711
POU2F2	JASPAR Predicted Transcription Factor Targets	1.0	null
RNH1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T8EM-1026-SM-3DB7M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20248
Protein_GCN5_20946988	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S95S-1226-SM-4GICG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56427
CBX3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K41289356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10322
BRD-K86638309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35249
hexestrol-5776	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K71755056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76887
BRD-K07600484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02152
KRT9	Pathway Commons Protein-Protein Interactions	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8881251-18_2022_4183_MOESM2_ESM.xlsx-ERM_vs_P1-DEGs_ERM_versus_P1_organoids_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
ATP1A2	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8RZ-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8608
GATA1	ChEA Transcription Factor Targets	1.0	null
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
TMED9	Pathway Commons Protein-Protein Interactions	1.0	null
SAMSN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00741439
extracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
DDX39B	Pathway Commons Protein-Protein Interactions	1.0	null
PIM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00537258
GNAO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0060532
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
Perturb_18007_Mut_Card14_SRP260070	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-T5JW-1626-SM-3GADZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4855
KGN	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.11316
BRD-K87275815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24665
BRD-K43023353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24628
GTEX-XLM4-0726-SM-4AT64	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16959
TNFRSF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28211
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN011_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7348
ANKRD44	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00721213
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
CSAD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00433377
PSMA5	Pathway Commons Protein-Protein Interactions	1.0	null
filament	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.267102
SYNCRIP	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PTGER2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00581211
hsa-miR-149	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
NCIH2087	DepMap CRISPR Gene Dependency	1.0	2.35796
BRD-A94420133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02284
EoL-1-cell	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.12368
plumule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.092109
GTEX-U3ZM-0626-SM-4DXTV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R55G-1626-SM-48FF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908124
GTEX-R55G-2526-SM-2TC6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32903
Syndromic X-linked intellectual disability Shashi type	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
BRD-K38985961_T5345967_HT115_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QEG5-0226-SM-2I5GI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38024
MCM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00424826
GTEX-PWN1-0126-SM-2I3FK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69131
GTEX-OXRO-0126-SM-2YUN4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01038
GTEX-WFG8-2126-SM-3GIKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983451
GTEX-O5YV-0526-SM-2I5GE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973738
ANP32A	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPH2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U8XE-0226-SM-4E3J3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16184
TECR	Pathway Commons Protein-Protein Interactions	1.0	null
FASN	Pathway Commons Protein-Protein Interactions	1.0	null
THPO	MSigDB Cancer Gene Co-expression Modules	1.0	null
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14932
UTRN	Pathway Commons Protein-Protein Interactions	1.0	null
Skin pilomatrix carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
CRCGN015_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.66719
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.79196
SMAP2	Pathway Commons Protein-Protein Interactions	1.0	null
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.94309
CD200	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00652784
ARPC3	Pathway Commons Protein-Protein Interactions	1.0	null
SEC31A	Pathway Commons Protein-Protein Interactions	1.0	null
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.769083
FLOT1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-O5YW-1426-SM-3MJHF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
CRCGN016_MCF10A.WT.HP_24H:E22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5572
EW7	DepMap CRISPR Gene Dependency	1.0	3.30227
GTEX-TSE9-0126-SM-3DB83	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03413
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20274
Sarcoma_SARC_TCGA-MB-A8JK-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hypocotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.090885
DSC1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QV44-0008-SM-447AX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861313
UBA52	Pathway Commons Protein-Protein Interactions	1.0	null
AARS	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.74783
Actinic keratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.19359
LYPLA2	Pathway Commons Protein-Protein Interactions	1.0	null
SRSF7	Pathway Commons Protein-Protein Interactions	1.0	null
BEND5	Pathway Commons Protein-Protein Interactions	1.0	null
homatropine-5477	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FBLIM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00550492
EIF3A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878182
TRAPPC13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00518575
carisoprodol-1314	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AGO1	Pathway Commons Protein-Protein Interactions	1.0	null
VTN	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XBED-1926-SM-47JYP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07597
Frontal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
DAB2	Pathway Commons Protein-Protein Interactions	1.0	null
structural constituent of cytoskeleton	GO Molecular Function Annotations 2015	1.0	null
keloid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.454126
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.165
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5495
200d	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.747
molecular_function	GO Molecular Function Annotations 2015	1.0	null
BRD-K60531990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17837
GTEX-U412-2026-SM-4DXSI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-XYKS-2426-SM-4AT43	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
abnormal tail pigmentation	MPO Gene-Phenotype Associations	1.0	null
RPS21	Pathway Commons Protein-Protein Interactions	1.0	null
CUL3	Pathway Commons Protein-Protein Interactions	1.0	null
CBS	Pathway Commons Protein-Protein Interactions	1.0	null
A-Netherlands-602-2009(H1N1)_12Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.01916
GTEX-X4EO-0326-SM-3P5YO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.14289
NB69	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.07601
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0906
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9518
TXN	Pathway Commons Protein-Protein Interactions	1.0	null
GSTK1	Pathway Commons Protein-Protein Interactions	1.0	null
PDXK	Pathway Commons Protein-Protein Interactions	1.0	null
RPS26	Pathway Commons Protein-Protein Interactions	1.0	null
SCAP	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A_48H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04729
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1171
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
RPL21	Pathway Commons Protein-Protein Interactions	1.0	null
anatomical structure development	GO Biological Process Annotations 2015	1.0	null
GTEX-QVJO-1626-SM-2S1QW	GTEx Tissue Sample Gene Expression Profiles	1.0	2.20411
Hair medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.474
HUWE1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K01668149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29834
GTEX-PX3G-0126-SM-2I3EN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11711
NUDT21	Pathway Commons Protein-Protein Interactions	1.0	null
PTPLAD1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A10417568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1705
496100363_TCx_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	6.36456
TMIGD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00720699
GTEX-OXRL-0126-SM-2YUMP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13704
EIF3L	Pathway Commons Protein-Protein Interactions	1.0	null
GNB2L1	Pathway Commons Protein-Protein Interactions	1.0	null
MAP3K21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00500215
SLC9A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00489384
pempidine-6027	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.562
CHMP4B	Pathway Commons Protein-Protein Interactions	1.0	null
WM278	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-TMMY-0126-SM-4DXTP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889621
AHSA1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U4B1-0226-SM-4DXU8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
CAMSAP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532446
BRD-K73540839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38747
NAA15	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K83721789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29335
WM793	CCLE Cell Line Gene CNV Profiles	-1.0	-2.32252
EPLC272H	CCLE Cell Line Gene CNV Profiles	1.0	1.66622
MACF1	Pathway Commons Protein-Protein Interactions	1.0	null
Intermediate filament cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.055
APOA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00514171
MINK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00518108
GTEX-R55D-1526-SM-48FEJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.974346
STOM	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPA0	Pathway Commons Protein-Protein Interactions	1.0	null
SART3	Pathway Commons Protein-Protein Interactions	1.0	null
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06037
trioxysalen-5736	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A55393291_TESTOSTERONE_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FERMT3	Pathway Commons Protein-Protein Interactions	1.0	null
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.2968
DENND3	Pathway Commons Protein-Protein Interactions	1.0	null
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59576
RBM22	Pathway Commons Protein-Protein Interactions	1.0	null
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.327
BRD-K44339278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54218
epidermis development	GO Biological Process Annotations 2023	1.0	null
C32	DepMap CRISPR Gene Dependency	1.0	5.15586
ULK3	Pathway Commons Protein-Protein Interactions	1.0	null
Internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.55
TUBB3	Pathway Commons Protein-Protein Interactions	1.0	null
SERBP1	Pathway Commons Protein-Protein Interactions	1.0	null
Anhidrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
TADA2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00470115
GSE120612_4_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9380317-13045_2022_1327_MOESM3_ESM.xlsx-Table_S4-Table_S4_Top_500_differentially_modified_gene_bodies_between_AA_and_EA_patients_with_MM_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K50685439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19089
RAB3GAP2	Pathway Commons Protein-Protein Interactions	1.0	null
HEATR1	Pathway Commons Protein-Protein Interactions	1.0	null
Hair root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.741
BRD-K17122222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90432
TOLLIP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00728313
primary auditory cortex (core)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.34933
SAR1A	Pathway Commons Protein-Protein Interactions	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2616
GTEX-V1D1-2226-SM-3NMAX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26348
Hypertrichosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.331
SMC4	Pathway Commons Protein-Protein Interactions	1.0	null
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1349
BLZF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00537934
periodontium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.312232
FOXK1	Pathway Commons Protein-Protein Interactions	1.0	null
TGM3	Pathway Commons Protein-Protein Interactions	1.0	null
SCC9	CCLE Cell Line Gene CNV Profiles	-1.0	-1.63609
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
FOXA1-26743006-CHIP-SEQ-LNCAP-ABL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
IFIT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0054254
EPRS	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TSE9-2226-SM-4DXUR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967155
PHB2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K20644549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26875
PMC11354204-JCB_202308099_TableS1.xlsx-TFEB-Flag_IP-Protein_name_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
epithelium development	GO Biological Process Annotations 2015	1.0	null
GTEX-XQ8I-0926-SM-4BOOF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02407
EIF2S1	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H2087	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
bromovanin	CTD Gene-Chemical Interactions	1.0	null
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.7145
salicyl-alcohol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49874
alopecia-mental retardation syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
OCT1-27270436-CHIP-SEQ-PROSTATE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K64317740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35279
BRD-K32628102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25027
Peptidase inhibitor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.159
GTEX-XOT4-0626-SM-4B66L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23692
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JY-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C8A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00623391
RMG-I	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RUNX1-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_DOWNREGULATED_IN_ERGhigh_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
MIA PACA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42184
SST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539899
CRD-mediated mRNA stability complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.023
CRCGN015_MCF10A.WT.HP_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13936
H3K9me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.048411
BRD-K32699895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00155
Central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.467
Pancreatic adenocarcinoma_PAAD_TCGA-US-A77J-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAU1	Pathway Commons Protein-Protein Interactions	1.0	null
arthrogryposis, renal dysfunction, and cholestasis 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.185
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1726
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1276
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GMPS	Pathway Commons Protein-Protein Interactions	1.0	null
ATP6V1G2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skin benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
hsa-miR-4644	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Lung adenocarcinoma_LUAD_TCGA-44-5645-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IGHM	Pathway Commons Protein-Protein Interactions	1.0	null
Melanoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.718
XRCC6	Pathway Commons Protein-Protein Interactions	1.0	null
KRT14	Pathway Commons Protein-Protein Interactions	1.0	null
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070569
BCL11A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00588842
RUBCNL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602271
Autosomal recessive congenital ichthyosis 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.854
BRD-K97949309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05647
hair follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.07971
inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08274
TFRC	Pathway Commons Protein-Protein Interactions	1.0	null
DUT	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10246347-12859_2023_5340_MOESM7_ESM.xlsx-GATA1_HDAC_PPI-Unnamed_1_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
NOP2	Pathway Commons Protein-Protein Interactions	1.0	null
YWHAH	Pathway Commons Protein-Protein Interactions	1.0	null
NHP2L1	Pathway Commons Protein-Protein Interactions	1.0	null
AAK1	Pathway Commons Protein-Protein Interactions	1.0	null
RPL3	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4335-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.6047
GTEX-U3ZH-0008-SM-4DXT2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
BRD-A64091909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40664
KP2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46762
ATXN2L	Pathway Commons Protein-Protein Interactions	1.0	null
HIST1H2AA	Pathway Commons Protein-Protein Interactions	1.0	null
KDM2B-26808549-CHIP-SEQ-SIL-ALL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MRPS14	Pathway Commons Protein-Protein Interactions	1.0	null
PAIP2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K18864235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83575
GRWD1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K70093308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52901
ACAN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496295
CALM1	Pathway Commons Protein-Protein Interactions	1.0	null
Keratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.337
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54745
MCM2	Pathway Commons Protein-Protein Interactions	1.0	null
FLG	Pathway Commons Protein-Protein Interactions	1.0	null
DTX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00577485
BACH1	ENCODE Transcription Factor Targets	1.0	null
SW1463	DepMap CRISPR Gene Dependency	1.0	2.62351
GTEX-XMD1-2826-SM-4AT5F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
abnormal foot pigmentation	MPO Gene-Phenotype Associations	1.0	null
ITGA2	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K69659917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.32847
DYNLL1	Pathway Commons Protein-Protein Interactions	1.0	null
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.573439
Immune system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HCC78	DepMap CRISPR Gene Dependency	1.0	2.18419
CRCGN016_MCF10A.TP53.M_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.13435
H3K27me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Vaginal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
BRD-K49528360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26645
TNNI3K	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00468601
GPC4	Pathway Commons Protein-Protein Interactions	1.0	null
Organism form	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
TOP1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN014_HEPG2_3H:F09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2341
Liver hepatocellular carcinoma_LIHC_TCGA-MI-A75H-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EJM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56596
TLN1	Pathway Commons Protein-Protein Interactions	1.0	null
KRT35	Pathway Commons Protein-Protein Interactions	1.0	null
single-multicellular organism process	GO Biological Process Annotations 2015	1.0	null
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.83599
CRCGN015_HEPG2_48H:E22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4423
dorsolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.932998
REG1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00666661
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21442
ACP1	Pathway Commons Protein-Protein Interactions	1.0	null
dienestrol-5727	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ETF1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10170086-41598_2023_34519_MOESM6_ESM.xlsx-Sheet3-The_overlapping_genes_between_significantly_co-expressed_genes_and_significantly_differentially_expressed_genes_of_BARX2_in_LIHC_BARX2	Rummagene Transcription Factor Associations 2026	1.0	null
MKN45	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	3.32897
BRD-U61997977_WZ-4-145_SKBR3_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RPL7L1	Pathway Commons Protein-Protein Interactions	1.0	null
intermediate filament	GO Cellular Component Annotations 2025	1.0	null
xylazine-4147	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TFAM	Pathway Commons Protein-Protein Interactions	1.0	null
Intermediate filament	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
BRD-K77520720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23286
BRD-K19492738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24892
Skin	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K72484719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04838
Epidermolytic hyperkeratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.216
BRIX1	Pathway Commons Protein-Protein Interactions	1.0	null
AKR1C1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00568014
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AN-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DOK1	Pathway Commons Protein-Protein Interactions	1.0	null
PRDX2	Pathway Commons Protein-Protein Interactions	1.0	null
RRP1	Pathway Commons Protein-Protein Interactions	1.0	null
CAPZB	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
KMT2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00575747
DCUN1D1	Pathway Commons Protein-Protein Interactions	1.0	null
tilmicosin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73394
MDA MB435	BioGPS Cell Line Gene Expression Profiles	1.0	1.2604
GTEX-X4EP-0626-SM-3P621	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01846
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.959752
CML-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
THOC2	Pathway Commons Protein-Protein Interactions	1.0	null
SRSF4	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8062-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K56488838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05051
STK10	Pathway Commons Protein-Protein Interactions	1.0	null
RAB1A	Pathway Commons Protein-Protein Interactions	1.0	null
B800-850 antenna complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.647
NCIH2087	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
BRD-K12097074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55554
BRD-K63154470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59132
GSE142210_3_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
sulindac-168	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormality of the upper urinary tract	GWASdb SNP-Phenotype Associations	1.0	0.125671
RP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00454622
KRT31	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K28008176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05898
PFDN2	Pathway Commons Protein-Protein Interactions	1.0	null
Melanosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.434
DNAJC7	Pathway Commons Protein-Protein Interactions	1.0	null
CAV3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00486559
SRPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00480712
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
chronic kidney failure	GWASdb SNP-Disease Associations	1.0	0.434632
Large granular lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.633
E2F1	ChEA Transcription Factor Targets	1.0	null
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.7857
GSE224556,GSE224557_8_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JW-0726-SM-4DM6D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830296
GTEX-PVOW-0426-SM-2XCF8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918555
AZI2	Pathway Commons Protein-Protein Interactions	1.0	null
ANXA4	Pathway Commons Protein-Protein Interactions	1.0	null
CLNS1A	Pathway Commons Protein-Protein Interactions	1.0	null
PFN1	Pathway Commons Protein-Protein Interactions	1.0	null
LIN7A	Pathway Commons Protein-Protein Interactions	1.0	null
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.232317
keratinocyte migration	GO Biological Process Annotations 2023	1.0	null
Stratified epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.913
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
VCP	Pathway Commons Protein-Protein Interactions	1.0	null
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.593
BRD-A42579861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55165
IGR37	CCLE Cell Line Gene CNV Profiles	-1.0	-1.74009
GTEX-RU1J-0826-SM-46MUU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834857
PDIA4	Pathway Commons Protein-Protein Interactions	1.0	null
PAICS	Pathway Commons Protein-Protein Interactions	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.321685
RPL30	Pathway Commons Protein-Protein Interactions	1.0	null
including	GeneRIF Biological Term Annotations	1.0	null
SLAMF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536956
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.964203
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S23_LF_C1_24h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
SAF-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.991
CCK81	DepMap CRISPR Gene Dependency	1.0	2.10392
Lung squamous cell carcinoma_LUSC_TCGA-56-8307-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAP1A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QDT8-0011-R8A-SM-32PKE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-QCQG-1426-SM-48U22	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GDI2	Pathway Commons Protein-Protein Interactions	1.0	null
FAM120A	Pathway Commons Protein-Protein Interactions	1.0	null
GLO1	Pathway Commons Protein-Protein Interactions	1.0	null
EEF1D	Pathway Commons Protein-Protein Interactions	1.0	null
PIM1	Pathway Commons Protein-Protein Interactions	1.0	null
IL13	MSigDB Cancer Gene Co-expression Modules	1.0	null
SERPINB4	Pathway Commons Protein-Protein Interactions	1.0	null
HK2	Pathway Commons Protein-Protein Interactions	1.0	null
Blood platelet	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.217
congenital ichthyosiform erythroderma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.705547
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7394-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNASEH2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00675871
PRDX6	Pathway Commons Protein-Protein Interactions	1.0	null
FLOT2	Pathway Commons Protein-Protein Interactions	1.0	null
SPR	Pathway Commons Protein-Protein Interactions	1.0	null
electrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.707221
Lung squamous cell carcinoma_LUSC_TCGA-66-2755-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR1C	Pathway Commons Protein-Protein Interactions	1.0	null
PCCA	Pathway Commons Protein-Protein Interactions	1.0	null
Seborrheic keratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
CS1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DDX3X	Pathway Commons Protein-Protein Interactions	1.0	null
MYH9	Pathway Commons Protein-Protein Interactions	1.0	null
KCNH2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K77578964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11053
ACTR3	Pathway Commons Protein-Protein Interactions	1.0	null
PA2G4	Pathway Commons Protein-Protein Interactions	1.0	null
DLST	Pathway Commons Protein-Protein Interactions	1.0	null
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-QEG4-0526-SM-48TZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849358
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91348
RPS29	Pathway Commons Protein-Protein Interactions	1.0	null
MIF	Pathway Commons Protein-Protein Interactions	1.0	null
CP-320650-01-4379	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.18251
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913576
Dowling-Degos disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.781
Exfoliative ichthyosis	ClinVar Gene-Phenotype Associations 2025	1.0	null
GTEX-XGQ4-1626-SM-4AT6J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
children	GeneRIF Biological Term Annotations	1.0	null
cell proliferation	GO Biological Process Annotations 2015	1.0	null
TRIM21	Pathway Commons Protein-Protein Interactions	1.0	null
LIMA1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XBED-2226-SM-47JYQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19914
NIPSNAP1	Pathway Commons Protein-Protein Interactions	1.0	null
CALCOCO2	Pathway Commons Protein-Protein Interactions	1.0	null
PLXNA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521214
ERCC4	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K49995660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19781
DIAPH1	Pathway Commons Protein-Protein Interactions	1.0	null
RBMX	Pathway Commons Protein-Protein Interactions	1.0	null
IGF2R	Pathway Commons Protein-Protein Interactions	1.0	null
ACP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00618883
AHNAK	Pathway Commons Protein-Protein Interactions	1.0	null
PPP4C	Pathway Commons Protein-Protein Interactions	1.0	null
ADRB2	Pathway Commons Protein-Protein Interactions	1.0	null
Hair follicle inner root sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.907
PMC11073972-41375_2024_2232_MOESM2_ESM.xlsx-Curated_GSEA_gene_sets-TAL1_SANDA_ET_AL_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-361-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GLA	Pathway Commons Protein-Protein Interactions	1.0	null
CAPN1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN013_HEPG2_24H:P07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01936
PMC8881251-18_2022_4183_MOESM3_ESM.xlsx-ERM_vs_P4-DEGs_ERM_versus_P4_organoids_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
dactinomycin_homo sapiens_gpl7172_gse12459	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RPSA	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A99644411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31591
SUM1315MO2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.924064
PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
POLB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00790037
seed	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081924
ADAMTSL4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K44086628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49993
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MLEC	Pathway Commons Protein-Protein Interactions	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.592
H3K27me3_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPID	Pathway Commons Protein-Protein Interactions	1.0	null
CACYBP	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TMZS-0126-SM-3DB9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15312
GABARAPL2	Hub Proteins Protein-Protein Interactions	1.0	null
GTF2B	Pathway Commons Protein-Protein Interactions	1.0	null
ITGAV	Pathway Commons Protein-Protein Interactions	1.0	null
dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.18651
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q734-1126-SM-48TZY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
NCOA7	Pathway Commons Protein-Protein Interactions	1.0	null
GUCY1A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00601856
cytoskeletal part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-SUCS-1926-SM-32PM3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53041
HSP90B1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WHPG-2626-SM-3NMBR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35788
GYG1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-518a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A4BB-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hs-939-T	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.29001
GJD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0086911
IRF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3083
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
RAB39A	Pathway Commons Protein-Protein Interactions	1.0	null
ichthyosis bullosa of siemens	OMIM Gene-Disease Associations	1.0	null
GTEX-U3ZN-0526-SM-4DXTH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886864
increased foot pad pigmentation	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K84260700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85895
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.4311
BRD-K87990170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03932
BRD-K82852523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21798
OCIM1	CCLE Cell Line Gene Expression Profiles	1.0	1.49325
RPS6	Pathway Commons Protein-Protein Interactions	1.0	null
TAL1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AZ-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QMRM-0626-SM-447BQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
HSPE1	Pathway Commons Protein-Protein Interactions	1.0	null
BNIPL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00694091
Dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.1
KCNK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00526486
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4202
BACE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00676791
GTEX-QEG4-0226-SM-2S1PY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67283
EPB41	Pathway Commons Protein-Protein Interactions	1.0	null
KP363T	DepMap CRISPR Gene Dependency	1.0	2.64773
BRD-K11545984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33235
KPNB1	Pathway Commons Protein-Protein Interactions	1.0	null
DNAJB1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K20501114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06536
KRT8	Pathway Commons Protein-Protein Interactions	1.0	null
TREML1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601319
Mite infestation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
cell motility	GO Biological Process Annotations 2015	1.0	null
TMC1	Pathway Commons Protein-Protein Interactions	1.0	null
GABARAPL1	Hub Proteins Protein-Protein Interactions	1.0	null
DMPK	MSigDB Cancer Gene Co-expression Modules	1.0	null
FAM83H	Pathway Commons Protein-Protein Interactions	1.0	null
CKAP5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K06876397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14125
UNC80	Pathway Commons Protein-Protein Interactions	1.0	null
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31196
HNRNPH3	Pathway Commons Protein-Protein Interactions	1.0	null
RPL10L	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.17492
VMRC-LCD	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
BRD-K91900765_VX-745_PC3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TF	Pathway Commons Protein-Protein Interactions	1.0	null
WDR62	Pathway Commons Protein-Protein Interactions	1.0	null
TSR1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RWSA-0226-SM-2XCBA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87754
EIF3F	Pathway Commons Protein-Protein Interactions	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042414
PRKAA1	Pathway Commons Protein-Protein Interactions	1.0	null
ANXA7	Pathway Commons Protein-Protein Interactions	1.0	null
practolol-5664	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal skin morphology	MPO Gene-Phenotype Associations	1.0	null
ILF2	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2E	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OHPN-0011-R9A-SM-4DXUH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900566
Lung squamous cell carcinoma_LUSC_TCGA-34-5239-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K94728263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00206
BRD-K94518115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01541
HIST2H2BE	Pathway Commons Protein-Protein Interactions	1.0	null
KMS-12-BM	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.46421
bullosa	GeneRIF Biological Term Annotations	1.0	null
BRD-K15800236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.619
Ovary	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.717
FBL	Pathway Commons Protein-Protein Interactions	1.0	null
FLNB	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U412-0226-SM-3NMC8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826324
CD1C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00692111
Acute Myeloid Leukemia_LAML_TCGA-AB-2977-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KRT6C	Pathway Commons Protein-Protein Interactions	1.0	null
IFNA1	MSigDB Cancer Gene Co-expression Modules	1.0	null
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854555
intermediate filament cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
membrane	GO Cellular Component Annotations 2015	1.0	null
LRIT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608317
PSMC2	Pathway Commons Protein-Protein Interactions	1.0	null
EGF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0141933
CUL2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OOBK-0126-SM-2YUND	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56564
KRTAP5-8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00484375
SRY-25088423-EMBRYONIC-GONADS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Diabetic Nephropathies	dbGAP Gene-Trait Associations	1.0	0.043343
PES1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3869
White sponge nevus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.067
BRD-K52735829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41269
SNRPD2	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4438	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
AIMP2	Pathway Commons Protein-Protein Interactions	1.0	null
E2F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55058
MAP1LC3B	Pathway Commons Protein-Protein Interactions	1.0	null
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6414
D-283MED	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q734-1426-SM-48TZQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069929
CRBN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00376211
GSE157592_1_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FN1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S05_LF_C2_3h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
CTPS1	Pathway Commons Protein-Protein Interactions	1.0	null
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	1.0	6.85929
Upper epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.812
PTRF	Pathway Commons Protein-Protein Interactions	1.0	null
STRAP	Pathway Commons Protein-Protein Interactions	1.0	null
ERG-20517297-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC9169777-pnas.2120787119.sd07.xlsx-Sheet1-Dataset_S7_Significantly_differentially_expressed_genes_between_G2_and_GATA3_WT_T-ALL_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
limbs/digits/tail phenotype	MPO Gene-Phenotype Associations	1.0	null
CUL4A	Pathway Commons Protein-Protein Interactions	1.0	null
RUNX1	MSigDB Cancer Gene Co-expression Modules	1.0	null
EXOSC3	Pathway Commons Protein-Protein Interactions	1.0	null
KRR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00543301
ALDH18A1	Pathway Commons Protein-Protein Interactions	1.0	null
LAMP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00663491
SKM1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.00341
Erythrokeratodermia variabilis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.468
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7326
B-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.267
B4GALNT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00506381
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QCQG-1326-SM-48U24	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830904
PANC0813	DepMap CRISPR Gene Dependency	1.0	2.07796
cefazolin-3686	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HLA-DQA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00978573
Acanthoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.469
EIF3I	Pathway Commons Protein-Protein Interactions	1.0	null
ECH1	Pathway Commons Protein-Protein Interactions	1.0	null
SAOS2_BONE	CCLE Cell Line Proteomics	1.0	2.48789
BRD-K25993054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07442
orbital frontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.35442
GTEX-QESD-1426-SM-2S1R9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89274
MAPK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00549442
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-Q734-0126-SM-48U1E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-VJYA-1126-SM-3GIJU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97038
GTEX-Q2AG-0008-SM-48U2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898277
duodenal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.995425
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70648
BRD-K40361885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36812
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MTAP	Pathway Commons Protein-Protein Interactions	1.0	null
PSD4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A77440546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64769
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q7-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-185	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.132
plant form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.327164
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20U-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Merocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.443
RPMI-7951	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	3.25375
STAT3	JASPAR Predicted Transcription Factor Targets	1.0	null
LY-294002-501	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
testing	GeneRIF Biological Term Annotations	1.0	null
RPL19	Pathway Commons Protein-Protein Interactions	1.0	null
corneal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.182957
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31896
EBNA1BP2	Pathway Commons Protein-Protein Interactions	1.0	null
TARS	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5889-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
peptide cross-linking	GO Biological Process Annotations 2025	1.0	null
cell activation	GO Biological Process Annotations 2015	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-8470-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	1.0	1.00921
CCT6A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K39193666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44246
BRD-A13082766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63284
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A86F-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.32105
MMP23A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00695907
ATP5L	Pathway Commons Protein-Protein Interactions	1.0	null
CSTA	Pathway Commons Protein-Protein Interactions	1.0	null
REN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00433908
PRKDC	Pathway Commons Protein-Protein Interactions	1.0	null
basal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.78522
BRD-K16911140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28829
CAL-120	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.7466
COPS5	Pathway Commons Protein-Protein Interactions	1.0	null
Dorsum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.325
Contact Hypersensitivity	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K87712055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68174
nonepidermolytic palmoplantar keratoderma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.10594
RAB5C	Pathway Commons Protein-Protein Interactions	1.0	null
ERLIN2	Pathway Commons Protein-Protein Interactions	1.0	null
CLIC1	Pathway Commons Protein-Protein Interactions	1.0	null
ATP5C1	Pathway Commons Protein-Protein Interactions	1.0	null
DYNC1I2	Pathway Commons Protein-Protein Interactions	1.0	null
UBA5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K56590597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02382
alverine-1426	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
BRD-K96970199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16232
KIDINS220	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH660	CCLE Cell Line Gene CNV Profiles	1.0	1.97268
PKN1	Pathway Commons Protein-Protein Interactions	1.0	null
UBL5	Pathway Commons Protein-Protein Interactions	1.0	null
CKAP4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55D-0008-SM-48FEV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.978378
Hematopoietic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.633
GTEX-U3ZN-1926-SM-4DXSG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
pigmentation phenotype	MPO Gene-Phenotype Associations	1.0	null
H3K27me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KRT75	Pathway Commons Protein-Protein Interactions	1.0	null
GAD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00637076
GTEX-U4B1-0826-SM-4DXTW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850234
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2373
PCBP2	Pathway Commons Protein-Protein Interactions	1.0	null
ATF1	ENCODE Transcription Factor Targets	1.0	null
SMARCA4	Pathway Commons Protein-Protein Interactions	1.0	null
Sebocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.87
NR3C1	JASPAR Predicted Transcription Factor Targets	1.0	null
dorsolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.897001
GTEX-U3ZN-0426-SM-4DXSH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86332
EDC4	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-8266-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mouth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.541773
IGHG1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K89305325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31364
EVPL	Pathway Commons Protein-Protein Interactions	1.0	null
SIGIRR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522477
BRD-K90049800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70139
Autosomal recessive congenital ichthyosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.219
palmoplantar keratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.980952
Pemphigus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
BRD-K03599766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23994
multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
genistein-382	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.955326
BRD-K73604422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36848
BRD-A60245366_AS-601245_MCF10A_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-8161-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PSMA3	Pathway Commons Protein-Protein Interactions	1.0	null
PCNA	Pathway Commons Protein-Protein Interactions	1.0	null
CNN2	Pathway Commons Protein-Protein Interactions	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
abnormal head morphology	MPO Gene-Phenotype Associations	1.0	null
Periplasmic flagellum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.601
PPARG	JASPAR Predicted Transcription Factor Targets	1.0	null
EIF3H	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-12q13_11_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
AP2A1	Pathway Commons Protein-Protein Interactions	1.0	null
Hyperkeratosis	DisGeNET Gene-Disease Associations	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.25682
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
abnormal kidney morphology	MGI Mouse Phenotype Associations 2023	1.0	null
BAG6	Pathway Commons Protein-Protein Interactions	1.0	null
MMAA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.005981
GTEX-Q2AH-0626-SM-48TZJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.914262
BRD-K67666705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4955
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R53T-0726-SM-48FCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863363
Integrin alpha6-beta4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.058
Epidermal stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.108
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
TBX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00518594
GTEX-QMR6-1326-SM-32PLB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
TTBK2	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-875-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
BRD-K82662168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47968
CYP2C8	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K95935249	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69209
VCAP	CCLE Cell Line Gene Expression Profiles	1.0	1.34763
TOP2A	Pathway Commons Protein-Protein Interactions	1.0	null
COL8A1	Pathway Commons Protein-Protein Interactions	1.0	null
Extracellular exosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
ACAT1	Pathway Commons Protein-Protein Interactions	1.0	null
DNAJC10	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K95648552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29002
GTEX-U8XE-0326-SM-3DB8P	GTEx Tissue Sample Gene Expression Profiles	1.0	2.31163
ITPRIPL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00561425
DAZAP1	Pathway Commons Protein-Protein Interactions	1.0	null
phenotypic abnormality	HPO Gene-Disease Associations	1.0	null
hydrastinine-1436	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CCL24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00460042
MKN7	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61924
BRD-K74445272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15932
RPS25	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WFON-1926-SM-3LK7L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999963
Kidney Chromophobe_KICH_TCGA-KN-8434-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RANBP2	Pathway Commons Protein-Protein Interactions	1.0	null
supramolecular fiber organization	GO Biological Process Annotations 2023	1.0	null
GTEX-Q734-0826-SM-48U1G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-O5YT-0126-SM-48TBW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13088
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.190281
trans-Golgi network transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.744
CEACAM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00805007
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.16683
Epidermolytic palmoplantar keratoderma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.658
EFTUD2	Pathway Commons Protein-Protein Interactions	1.0	null
HSPG2	Pathway Commons Protein-Protein Interactions	1.0	null
ACOX1	Pathway Commons Protein-Protein Interactions	1.0	null
PSMB6	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.67145
MARK2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X8HC-0126-SM-4E3JW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48739
HSPA4L	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.84606
SMAD3	Hub Proteins Protein-Protein Interactions	1.0	null
ASAH1	Pathway Commons Protein-Protein Interactions	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.04062
GTEX-XBEW-0126-SM-4AT66	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PMC1683566__F5	PFOCR Pathway Figure Associations 2024	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K89767945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30009
NCI-H1650	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.09257
LGALS7B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932505
SQSTM1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12307501-Table1.xlsx-ST12-Supplementary_Table_12_Results_of_the_comparisons_of_AP_expression_levels_between_different_biological_age_groups_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_4_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-TMMY-0226-SM-33HBA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62615
GTEX-XBEC-1526-SM-4AT68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
BRD-K48358706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0777
Cornified envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.419
GTEX-XLM4-0011-R2B-SM-4AT5Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
NDUFV2	Pathway Commons Protein-Protein Interactions	1.0	null
SGOL2	Pathway Commons Protein-Protein Interactions	1.0	null
abnormal skin pigmentation	MGI Mouse Phenotype Associations 2023	1.0	null
C-4-I	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.49019
HT-144	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	3.00604
hsa-miR-1253	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
HMGB2	Pathway Commons Protein-Protein Interactions	1.0	null
AXIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0042072
NCI-H2347	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Periodontal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
CHD7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00383247
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	0.102001
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900566
BRD-K12107215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9251
SLC22A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00579828
BRD-K35429158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44511
MRTO4	Pathway Commons Protein-Protein Interactions	1.0	null
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13107
SUPT16H	Pathway Commons Protein-Protein Interactions	1.0	null
SG231	DepMap CRISPR Gene Dependency	1.0	2.67423
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredPeptides-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
AP2M1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K75637705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66648
AHCY	Pathway Commons Protein-Protein Interactions	1.0	null
GSE225900_1_v_0_hsdl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
pachyonychia congenita	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.24298
GTEX-TKQ2-0926-SM-4DXU5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.899197
Morphine	CTD Gene-Chemical Interactions	1.0	null
PSG9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00836167
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	288.0
BRD-K19320442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2321
HADHB	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K10906552_7887507_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PSMA4	Pathway Commons Protein-Protein Interactions	1.0	null
IHH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00595869
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.02671
COPS6	Pathway Commons Protein-Protein Interactions	1.0	null
J82	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45641
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02508
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
IQGAP2	Pathway Commons Protein-Protein Interactions	1.0	null
RAB7A	Pathway Commons Protein-Protein Interactions	1.0	null
ACTL6A	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77346
NALM-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
HSPH1	Pathway Commons Protein-Protein Interactions	1.0	null
MAP1LC3A	Hub Proteins Protein-Protein Interactions	1.0	null
Natural killer cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.633
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K35308744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06183
tonsil_8b1	HPA Tissue Sample Gene Expression Profiles	1.0	1.02416
PPP2R5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00529786
JEKO1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.22905
ACADM	Pathway Commons Protein-Protein Interactions	1.0	null
P300-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Kidney	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.517
BRD-K76420749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18064
NF1	MSigDB Cancer Gene Co-expression Modules	1.0	null
GTEX-X4XX-1126-SM-3NMBY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881994
PELP1	Pathway Commons Protein-Protein Interactions	1.0	null
IDS	Pathway Commons Protein-Protein Interactions	1.0	null
increased ear pigmentation	MPO Gene-Phenotype Associations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2725-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SND1	Pathway Commons Protein-Protein Interactions	1.0	null
A549	BioGPS Cell Line Gene Expression Profiles	1.0	1.00921
skin_5e	HPA Tissue Sample Gene Expression Profiles	1.0	1.95944
uterine cervix	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Heavy chain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.188
small intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.124632
WSU-DLCL2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-P4QT-0226-SM-3LK68	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98243
PSMD9	Pathway Commons Protein-Protein Interactions	1.0	null
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WFG8-1726-SM-4LVM6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923977
EEF1G	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-O5YW-0126-SM-3LK6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04053
EIF4E	Pathway Commons Protein-Protein Interactions	1.0	null
Brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.15
BRD-K89806367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07067
HUH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59888
Hypertension	CTD Gene-Disease Associations	1.0	1.18293
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21935
RPS27	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.024
PSMA2	Pathway Commons Protein-Protein Interactions	1.0	null
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.273986
BRD-K73001304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32441
posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.55562
BRD-K18268126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16047
SBDS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00531663
BRD-K14392329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46288
protein binding	GO Molecular Function Annotations 2015	1.0	null
PPIH	Pathway Commons Protein-Protein Interactions	1.0	null
Tricellular tight junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.672
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
PDCD10	Pathway Commons Protein-Protein Interactions	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-4110-01A-02R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8104-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
positive regulation of developmental process	GO Biological Process Annotations 2023	1.0	null
Integumentary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.329
BRD-K81757081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60237
FYCO1	Pathway Commons Protein-Protein Interactions	1.0	null
RENBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00489641
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
preweaning lethality, incomplete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
ETS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1304
CRCGN017_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06615
GTEX-R55C-0008-SM-48FCF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883664
BRD-K86143816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21623
C1S	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00654378
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.0337
HSPA7	Pathway Commons Protein-Protein Interactions	1.0	null
Lassa Fever Virus_4hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.99918
fetal membrane	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.101778
BRD-K75981085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35795
CD8B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00578804
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
TUBA1B	Pathway Commons Protein-Protein Interactions	1.0	null
FSCN1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XLM4-0011-R9A-SM-4AT45	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846115
PRMT5	Pathway Commons Protein-Protein Interactions	1.0	null
ATG4A	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-548f	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
KRT80	Pathway Commons Protein-Protein Interactions	1.0	null
C18orf32	Pathway Commons Protein-Protein Interactions	1.0	null
BCOR-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-XMD1-0011-R11A-SM-4AT5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
MLANA	MSigDB Cancer Gene Co-expression Modules	1.0	null
HCC1806	GDSC Cell Line Gene Expression Profiles	1.0	1.43187
YLPM1	Pathway Commons Protein-Protein Interactions	1.0	null
Desmosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.941
UO31	BioGPS Cell Line Gene Expression Profiles	1.0	0.909149
ZW10	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K75036062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43783
BRD-K33748896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24017
SRP14	Pathway Commons Protein-Protein Interactions	1.0	null
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
AKR1C1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XUJ4-1826-SM-4BOOU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05028
nephropathy	GWASdb SNP-Phenotype Associations	1.0	0.552815
Gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.717
20220088-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
ONS-76	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ITGA4	Pathway Commons Protein-Protein Interactions	1.0	null
ATF3_01_33	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.27017
ZR75_1	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.11122
BRD-K91239327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02722
BRD-K62650632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34914
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.093756
MCF 10A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
WDFY3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X88G-0126-SM-47JZ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61546
KBTBD6	Pathway Commons Protein-Protein Interactions	1.0	null
ACTN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564496
DU4475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03329
Hematopoietic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.633
GTEX-QDT8-2926-SM-32PKC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
Kc cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.611
SLC22A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00612128
BRD-K22508525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18997
MAP2K7	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE184892_7_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-QMR6-0011-R5A-SM-32PKT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951512
oa1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.51
single-organism developmental process	GO Biological Process Annotations 2015	1.0	null
EIF6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K24877937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05388
PDCD1LG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00717715
CALU3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42978
CRCGN015_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0366
GTEX-XLM4-3026-SM-4AT6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
HEBP1	Pathway Commons Protein-Protein Interactions	1.0	null
KRT85	Pathway Commons Protein-Protein Interactions	1.0	null
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6828
EBNA1-20929547-CHIP-SEQ-RAJI-CELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
cytoplasm	GO Cellular Component Annotations 2015	1.0	null
GTEX-R3RS-0126-SM-3GIJL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64186
Keratinocyte_Skin_Human	CellMarker Gene-Cell Type Associations	1.0	null
RPL4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-REY6-1426-SM-48FDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
IL9R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0052089
GTEX-XMD1-0011-R6A-SM-4AT5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82662
GTEX-PWN1-2526-SM-48TDS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930861
H3K9me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Urinary system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.593
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848002
BRD-K52124788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38791
IFNA8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00624933
CAD cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.534
GTEX-QMR6-0011-R7A-SM-32PKL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PICALM	Pathway Commons Protein-Protein Interactions	1.0	null
grhl3_16949565_skin_lof_mouse_gpl1261_gds2629	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.859143
GTEX-TKQ1-0426-SM-4DXT4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
HERC5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00473104
PMC7450072-41598_2020_71096_MOESM1_ESM.xlsx-Table1_SS_vs_AA_RBC_lys-Gene_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-O5YT-1826-SM-32PK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
ANXA1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QMR6-0011-R6A-SM-32PKP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GPATCH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00672391
LXF289_LUNG	CCLE Cell Line Proteomics	1.0	4.19676
BRD-K91654198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3127
NCI-H1623	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
DYNC1LI1	Pathway Commons Protein-Protein Interactions	1.0	null
KRT32	Pathway Commons Protein-Protein Interactions	1.0	null
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R3RS-0726-SM-3GIJR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873708
HLA-B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QMR6-0011-R8A-SM-32PKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GALK1	Pathway Commons Protein-Protein Interactions	1.0	null
orbital frontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.54979
MAGEA9	MSigDB Cancer Gene Co-expression Modules	1.0	null
hsa-miR-527	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
SAMHD1	Pathway Commons Protein-Protein Interactions	1.0	null
hyperkeratosis	MGI Mouse Phenotype Associations 2023	1.0	null
DYX1C1	Pathway Commons Protein-Protein Interactions	1.0	null
PSMA7	Pathway Commons Protein-Protein Interactions	1.0	null
RPL14	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
Pachyonychia congenita	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.366
SNRPB2	Pathway Commons Protein-Protein Interactions	1.0	null
HSPA4	Pathway Commons Protein-Protein Interactions	1.0	null
RUNX-20019798-JUKART-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-XUW1-0926-SM-4BONX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02092
Gut	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
CAD	Pathway Commons Protein-Protein Interactions	1.0	null
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
YWHAE	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T6MN-0126-SM-32PLP	GTEx Tissue Sample Gene Expression Profiles	1.0	3.53088
IL1RL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00537741
SUPT11	CCLE Cell Line Gene Expression Profiles	1.0	2.2063
SRSF5	Pathway Commons Protein-Protein Interactions	1.0	null
TTC9C	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QDT8-0008-SM-48U2F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900884
BRD-K37564297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42741
NFAT5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00550574
PARP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00445609
CAL-78	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.55685
OV-90	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-4.63645
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VPS26A	Pathway Commons Protein-Protein Interactions	1.0	null
GABARAP	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q2AG-0926-SM-48U1Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
MCF12A	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.742136
arsenic trioxide_homo sapiens_gpl201_gse48441	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PUM1	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphoid cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Xanthophore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.008
BRD-K67626198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59828
253JBV	CCLE Cell Line Gene Expression Profiles	1.0	1.41836
KRT6B	Pathway Commons Protein-Protein Interactions	1.0	null
GSN	Pathway Commons Protein-Protein Interactions	1.0	null
RPF2	Pathway Commons Protein-Protein Interactions	1.0	null
Cerebral lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.9179
GTEX-UPJH-0326-SM-3GADU	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18808
GTEX-OXRP-0126-SM-3NB32	GTEx Tissue Sample Gene Expression Profiles	1.0	2.17538
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ichthyosis	GeneRIF Biological Term Annotations	1.0	null
esophagus	HPA Tissue Protein Expression Profiles	1.0	1.63028
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	89.7781
HNRNPUL2	Pathway Commons Protein-Protein Interactions	1.0	null
PSMD4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K43979194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07564
Dermal fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.408
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DST	Pathway Commons Protein-Protein Interactions	1.0	null
Papilloma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
CMTM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00509551
GRB2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GHSR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00609229
MAP3K4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00699401
ACSL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00744009
GSE131649_2_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RM2N-1426-SM-2TF4H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50477
BRD-K45077605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11462
non-membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061329
BRD-A95683194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14338
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.964512
Squamous epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.538
hereditary mucosal leukokeratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.77225
BRD-A85712510_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TYROBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00790695
TAL1_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD4	Pathway Commons Protein-Protein Interactions	1.0	null
SF3B1	Pathway Commons Protein-Protein Interactions	1.0	null
tongue epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.423054
PMC6073502__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5892-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW954	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.1427
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
HUT78	CCLE Cell Line Gene Expression Profiles	1.0	1.97086
epidermis development	GO Biological Process Annotations 2015	1.0	null
GTEX-NPJ8-0126-SM-2YUNR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27002
SERPINB12	Pathway Commons Protein-Protein Interactions	1.0	null
serous cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.580417
FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8429
TENM3	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MA-AA41-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10170086-41598_2023_34519_MOESM6_ESM.xlsx-Shee2-The_differentially_expressed_genes_between_the_BARX2_high_and_BARX2_low_group_of_LIHC_patients_BARX2	Rummagene Transcription Factor Associations 2026	1.0	null
NEK9	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredProteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SIK2	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-3139	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
ARF6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K60780031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90693
NUP214	Pathway Commons Protein-Protein Interactions	1.0	null
JUP	Pathway Commons Protein-Protein Interactions	1.0	null
epidermolysis bullosa simplex	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.30663
BRD-K40109091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08577
ARL2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WXYG-2326-SM-4E3I6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42089
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20274
Lung squamous cell carcinoma_LUSC_TCGA-77-6842-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JM1	CCLE Cell Line Gene CNV Profiles	1.0	2.59998
PMC5998130-41467_2018_4619_MOESM7_ESM.xlsx-specificity_NCOA3-Gene_Name_NCOA3	Rummagene Transcription Factor Associations 2026	1.0	null
IL15_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-7525-01A-31R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Allergic contact dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.891
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42184
BRD-K70735803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49255
RPS7	Pathway Commons Protein-Protein Interactions	1.0	null
protein complex	GO Cellular Component Annotations 2015	1.0	null
GTEX-QCQG-0126-SM-48U27	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841948
GTEX-Q2AI-0426-SM-48U13	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826231
Prostate adenocarcinoma_PRAD_TCGA-HC-A632-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K55815187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27884
QKI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00644672
SLC5A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00659026
Perturb_1294_KO_Krt17_SRP298760	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.58072
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QV31-0008-SM-447AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903884
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.388
U2SURP	Pathway Commons Protein-Protein Interactions	1.0	null
Phellem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.634
GTEX-XQ8I-0426-SM-4BOPO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10802
PAFAH1B2	Pathway Commons Protein-Protein Interactions	1.0	null
AMPD1	Pathway Commons Protein-Protein Interactions	1.0	null
tongue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.371994
RPL34	Pathway Commons Protein-Protein Interactions	1.0	null
Squamous cell neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.341
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.153688
keratinocyte migration	GO Biological Process Annotations 2025	1.0	null
BRD-K38487270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54165
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC11073972-41375_2024_2232_MOESM2_ESM.xlsx-REL-14_CD7_CD1a-_L-IC_DEG-DEG_L2FC_1_0_FDR_0_05_REL	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CL-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRC_DEPLETION_GDS3532_96_human_U2OS cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
EXOSC9	Pathway Commons Protein-Protein Interactions	1.0	null
LTV1	Pathway Commons Protein-Protein Interactions	1.0	null
GAK	Pathway Commons Protein-Protein Interactions	1.0	null
TRA2A	Pathway Commons Protein-Protein Interactions	1.0	null
EXOSC2	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H2452	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.09635
PMC10238271-41388_2023_2678_MOESM8_ESM.pdf-3-PAX5_PAX5	Rummagene Transcription Factor Associations 2026	1.0	null
MTHFD1L	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U3ZH-2026-SM-3DB78	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30671
HIPK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00489872
GALE	Pathway Commons Protein-Protein Interactions	1.0	null
GP1BB	Pathway Commons Protein-Protein Interactions	1.0	null
Corneal dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.367
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
COPS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15546
stamen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.25858
H3K9me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Tail	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.556
ARHGEF1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
BRD-K29767311_NCGC00183415-01_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HSP90AB2P	Pathway Commons Protein-Protein Interactions	1.0	null
HIF-2alpha_DEPLETION_GDS2760_643_human_Hypoxic MCF-7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-V1D1-2026-SM-3GAF4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08297
hair shaft	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.941785
CDC42BPA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540839
RS11846	BioGPS Cell Line Gene Expression Profiles	1.0	1.43856
ATP6V1B2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K91766181	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24609
Skin	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
TSC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0077967
CLIC2	Pathway Commons Protein-Protein Interactions	1.0	null
USP39	Pathway Commons Protein-Protein Interactions	1.0	null
PTPRB	MSigDB Cancer Gene Co-expression Modules	1.0	null
TUBB6	Pathway Commons Protein-Protein Interactions	1.0	null
LN-229	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.59682
Lung adenocarcinoma_LUAD_TCGA-44-2657-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GOLGA7	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S16_LF_C2_8h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
RPN2	Pathway Commons Protein-Protein Interactions	1.0	null
RVH-421	GDSC Cell Line Gene Expression Profiles	-1.0	-1.43204
YES1	Pathway Commons Protein-Protein Interactions	1.0	null
WHSC1	ENCODE Transcription Factor Targets	1.0	null
ABHD6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0040601
Epidermolysis bullosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.247
GTEX-OIZH-0126-SM-2HMIS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67613
HSPA8	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78058
GM2A	Pathway Commons Protein-Protein Interactions	1.0	null
BROX	Pathway Commons Protein-Protein Interactions	1.0	null
EPS15	Pathway Commons Protein-Protein Interactions	1.0	null
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.960642
CYP4Z2P	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-548a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S01_LF_C1_3h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
MRPS27	Pathway Commons Protein-Protein Interactions	1.0	null
VSTM2L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00621416
GSE98898_4_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Autosomal recessive congenital ichthyosis 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.428
LRPPRC	Pathway Commons Protein-Protein Interactions	1.0	null
BAG2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55C-1026-SM-48FCM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866161
RPL7A	Pathway Commons Protein-Protein Interactions	1.0	null
HSP90AA2	Pathway Commons Protein-Protein Interactions	1.0	null
OAT	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-3924-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFV	Pathway Commons Protein-Protein Interactions	1.0	null
MAGOH	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A01528713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36805
TAL1_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TUFM	Pathway Commons Protein-Protein Interactions	1.0	null
WDR11	Pathway Commons Protein-Protein Interactions	1.0	null
TPM3	Pathway Commons Protein-Protein Interactions	1.0	null
Infundibulum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.086
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.86991
KRT27	Pathway Commons Protein-Protein Interactions	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.434906
ANXA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00404274
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.905996
GTEX-X4EP-0126-SM-3P5YV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26856
BRD-K70949282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63987
TMED10	Pathway Commons Protein-Protein Interactions	1.0	null
RPS11	Pathway Commons Protein-Protein Interactions	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.378
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	52.6426
CRCGN014_HEPG2_3H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08447
Nipple	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.472
CHTOP	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K47237224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18577
GTEX-SN8G-0126-SM-32PLI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31522
BECKER	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XLM4-2026-SM-4AT4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
skin_5f	HPA Tissue Sample Gene Expression Profiles	1.0	1.77508
ZCCHC8	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5711-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
profenamine-3376	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K55479099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20954
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GIMAP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00470506
CRCGN017_MCF10A.WT.HP_24H:N11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08875
BRD-K18645499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05963
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
M07E	CCLE Cell Line Gene Expression Profiles	1.0	1.36355
U-698-M	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.24645
C7orf50	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-143	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
NUP93	Pathway Commons Protein-Protein Interactions	1.0	null
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.979046
SMARCA5	Pathway Commons Protein-Protein Interactions	1.0	null
496100312_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.14128
BRD-K41192699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74372
tacrolimus-169	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.52856
Bullous congenital ichthyosiform erythroderma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.734
GTEX-X62O-0126-SM-4E3JN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04086
BRD-K15008902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15664
GTEX-R55E-0126-SM-2TC5Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25456
BRD-K28375929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47423
spiramycin-3762	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PRSS1	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB7C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.7145
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NPHP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.725
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
KEAP1	Pathway Commons Protein-Protein Interactions	1.0	null
LOUCY	GDSC Cell Line Gene Expression Profiles	1.0	1.62102
RFC5	Pathway Commons Protein-Protein Interactions	1.0	null
RASSF1	Pathway Commons Protein-Protein Interactions	1.0	null
PKP1	Pathway Commons Protein-Protein Interactions	1.0	null
LARP1	Pathway Commons Protein-Protein Interactions	1.0	null
PRKAB1	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EB-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GFAP	Pathway Commons Protein-Protein Interactions	1.0	null
ZCCHC11	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K96491043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16967
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21935
electric organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.486716
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-XOTO-0126-SM-4B66N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83636
IL16	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K44265418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47787
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A5KG-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.979046
C84	DepMap CRISPR Gene Dependency	1.0	2.23877
hyperkeratosis	HPO Gene-Disease Associations	1.0	null
ae3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.115
amygdaloid complex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.73719
GTEX-QEL4-0008-SM-447AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
STAT3	MotifMap Predicted Transcription Factor Targets	1.0	null
CHRNA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00807072
STAT5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00538908
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.7324
RAE1	Pathway Commons Protein-Protein Interactions	1.0	null
BYSL	Pathway Commons Protein-Protein Interactions	1.0	null
Lung	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.678
Ichthyosis bullosa of Siemens	ClinVar Gene-Phenotype Associations 2025	1.0	null
RPL38	Pathway Commons Protein-Protein Interactions	1.0	null
NAP1L4	Pathway Commons Protein-Protein Interactions	1.0	null
IGR39	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44489
YWHAG	Pathway Commons Protein-Protein Interactions	1.0	null
KLHL12	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WI4N-1026-SM-3LK7N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17222
GTEX-R55G-1126-SM-48FDG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827374
ACACA	Pathway Commons Protein-Protein Interactions	1.0	null
U2AF2	Pathway Commons Protein-Protein Interactions	1.0	null
CIRBP	Pathway Commons Protein-Protein Interactions	1.0	null
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAPK8	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
NCI-H345	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CAPZA1	Pathway Commons Protein-Protein Interactions	1.0	null
PUF60	Pathway Commons Protein-Protein Interactions	1.0	null
LN235	DepMap CRISPR Gene Dependency	1.0	3.1894
intermediate filament cytoskeleton	GO Cellular Component Annotations 2015	1.0	null
impaired skin barrier function	MGI Mouse Phenotype Associations 2023	1.0	null
ERG-20517297-VCAP-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
stratified epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.06162
hsa-miR-4488	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GTEX-XUYS-0126-SM-47JWZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72382
lesions	GeneRIF Biological Term Annotations	1.0	null
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053884
DU-145	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K00620786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25132
SAR1B	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8046-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U4B1-1026-SM-4DXT1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839641
SUGP2	Pathway Commons Protein-Protein Interactions	1.0	null
VAMP8	Pathway Commons Protein-Protein Interactions	1.0	null
structural molecule activity	GO Molecular Function Annotations 2015	1.0	null
TTN	Pathway Commons Protein-Protein Interactions	1.0	null
EJM	DepMap CRISPR Gene Dependency	1.0	3.63709
RAC2	Pathway Commons Protein-Protein Interactions	1.0	null
CDSN	Pathway Commons Protein-Protein Interactions	1.0	null
SUB1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S7SF-1926-SM-4AT5B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.978092
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7183-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7888-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BNIP1	MSigDB Cancer Gene Co-expression Modules	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79068
Hemorrhage	CTD Gene-Disease Associations	1.0	1.22727
MOLT16	CCLE Cell Line Gene Expression Profiles	1.0	2.05133
NDUFS1	Pathway Commons Protein-Protein Interactions	1.0	null
KAT2A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE164494_0_v_2_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Hair shaft	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.933
ZNF638	Pathway Commons Protein-Protein Interactions	1.0	null
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17473
PTGES3	Pathway Commons Protein-Protein Interactions	1.0	null
SRM	Pathway Commons Protein-Protein Interactions	1.0	null
Intermediate filament cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
GJC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00863422
RPLP1	Pathway Commons Protein-Protein Interactions	1.0	null
NTSR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00664096
BRD-K27824953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97494
CFHR5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00521134
colon	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.900404
BRD-K73780763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16976
BRD-K46742113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47246
R3HCC1	Pathway Commons Protein-Protein Interactions	1.0	null
HADHA	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U3ZM-0926-SM-4DXSW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860325
RPL35	Pathway Commons Protein-Protein Interactions	1.0	null
HEC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HNRNPA1	Pathway Commons Protein-Protein Interactions	1.0	null
LN-229	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05714
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TT-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
integument phenotype	MPO Gene-Phenotype Associations	1.0	null
RPS4X	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12700831-41594_2025_1680_MOESM4_ESM.xlsx-D9_EC_Hits_2_5FC_Filtered_Out-Mapped_Gene_Symbol_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
Internal female genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HNRNPR	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q2AG-3026-SM-48U1L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850005
Polyketide synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.324
GATA1-19941826-K562-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4051
PMC9942993-pone.0281645.s002.xlsx-AR-as_all-ENSEMBL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12302463-12935_2025_3917_MOESM6_ESM.xls-MR-4980-MR_analysis_results_of_ieu-b-4980_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PFKL	Pathway Commons Protein-Protein Interactions	1.0	null
AR-27623747-22RV1-MOUSE-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
NUDHL1	CCLE Cell Line Gene CNV Profiles	1.0	1.67519
BIK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0056772
SAFB	Pathway Commons Protein-Protein Interactions	1.0	null
RBM15B	Pathway Commons Protein-Protein Interactions	1.0	null
Skin stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.13
KRT77	Pathway Commons Protein-Protein Interactions	1.0	null
RPS16	Pathway Commons Protein-Protein Interactions	1.0	null
EEF1A2	Pathway Commons Protein-Protein Interactions	1.0	null
primary auditory cortex (core)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.75524
CCRF-CEM	GDSC Cell Line Gene Expression Profiles	1.0	2.22457
Perturb_18382_KO_Izumo1r_SRP354764	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
HIST1H1B	Pathway Commons Protein-Protein Interactions	1.0	null
TKT	Pathway Commons Protein-Protein Interactions	1.0	null
Basal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
IL5RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00816706
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Epidermolytic acanthoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.071
PTPN23	Pathway Commons Protein-Protein Interactions	1.0	null
PMS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00511219
Corneal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.345
Lamellar body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.364
EIF2S3	Pathway Commons Protein-Protein Interactions	1.0	null
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-U3ZH-1426-SM-4DXSR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
BRD-K83916197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15883
SLC6A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00680706
Prepuce	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.284
DSP	Pathway Commons Protein-Protein Interactions	1.0	null
cytoskeleton	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
SSB	Pathway Commons Protein-Protein Interactions	1.0	null
EEA1	Pathway Commons Protein-Protein Interactions	1.0	null
laminin-5 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.247
ichthyosis	HPO Gene-Disease Associations	1.0	null
SRY	ChEA Transcription Factor Targets	1.0	null
golgi apparatus	GO Cellular Component Annotations 2015	1.0	null
IMMT	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN013_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4288
BRD-K71836501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01425
ventrolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.33162
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.75
Prostate adenocarcinoma_PRAD_TCGA-HC-8265-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
all	HPO Gene-Disease Associations	1.0	null
AIFM1	Pathway Commons Protein-Protein Interactions	1.0	null
FOXP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00503888
PREX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00465945
BRD-K42138859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16725
PRH2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K41729242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2565
SU-DHL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34097
LGR4	Pathway Commons Protein-Protein Interactions	1.0	null
protein modification process	GO Biological Process Annotations 2023	1.0	null
GTEX-RWSA-1126-SM-2XCAZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826515
GLRX3	Pathway Commons Protein-Protein Interactions	1.0	null
RPTN	Pathway Commons Protein-Protein Interactions	1.0	null
Mafb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.3058
BRD-K73500518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82708
SNU1214	CCLE Cell Line Gene Expression Profiles	1.0	1.76321
MKI67	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K31372389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19762
CAMK2D	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPL	Pathway Commons Protein-Protein Interactions	1.0	null
MYL4	Pathway Commons Protein-Protein Interactions	1.0	null
Hair follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.133
dorsolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.895961
KRT18	Pathway Commons Protein-Protein Interactions	1.0	null
CDK3	Pathway Commons Protein-Protein Interactions	1.0	null
VAPA	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887586
PMC12260418-pnas.2425984122.sd02.xlsx-TEAD1_6fraction_test_result-Unnamed_3_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
STX1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00496842
BRD-K84932026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04485
LMNB1	Pathway Commons Protein-Protein Interactions	1.0	null
AREG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00704929
Pigment granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.41
HSDL2	Pathway Commons Protein-Protein Interactions	1.0	null
TTC24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00517216
RPA1	Pathway Commons Protein-Protein Interactions	1.0	null
BMP2K	Pathway Commons Protein-Protein Interactions	1.0	null
STK33	Pathway Commons Protein-Protein Interactions	1.0	null
leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.094073
Hallux	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.592
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3897
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900566
IL4	MSigDB Cancer Gene Co-expression Modules	1.0	null
CCDC141	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00626061
GSE217541,GSE217543_3_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-FC-A5OB-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K86039224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38659
single-organism process	GO Biological Process Annotations 2015	1.0	null
PLOD1	Pathway Commons Protein-Protein Interactions	1.0	null
GABRG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00785442
NCIH2170	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32525
BRD-K81471597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01975
NCIH1105	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80464
confirmed	GeneRIF Biological Term Annotations	1.0	null
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.726065
DDX27	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6073502__F2	PFOCR Pathway Figure Associations 2023	1.0	null
PRPF3	Pathway Commons Protein-Protein Interactions	1.0	null
SUPB15	CCLE Cell Line Gene Expression Profiles	1.0	1.35062
NHP2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K02759046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35697
MLLT10	MSigDB Cancer Gene Co-expression Modules	1.0	null
Female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.717
PRDX3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K65868510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01036
golgi apparatus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14962
TEX10	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K66248685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25735
SKA2	Pathway Commons Protein-Protein Interactions	1.0	null
HUH6	DepMap CRISPR Gene Dependency	1.0	3.53622
GSTO1	Pathway Commons Protein-Protein Interactions	1.0	null
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4202
SGPL1	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPCL1	Pathway Commons Protein-Protein Interactions	1.0	null
PACSIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00747757
RPL22	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TKQ1-0526-SM-4DXTG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
EIF3C	Pathway Commons Protein-Protein Interactions	1.0	null
RPL26L1	Pathway Commons Protein-Protein Interactions	1.0	null
Epidermolysis bullosa simplex	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.399
CTSA	Pathway Commons Protein-Protein Interactions	1.0	null
GSE200099_2_v_0_honokiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.261964
NFATC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00368941
RPS13	Pathway Commons Protein-Protein Interactions	1.0	null
PRPF8	Pathway Commons Protein-Protein Interactions	1.0	null
APOE	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WY7C-2126-SM-3NB2R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26141
BRD-K62012036_GR-108_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K44549496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17874
GTEX-XQ3S-1526-SM-4BOOC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70663
POFUT2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XK95-0226-SM-4AT58	GTEx Tissue Sample Gene Expression Profiles	1.0	0.995735
phycobiont	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.267102
GTEX-WH7G-2026-SM-3NMBL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03727
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K38347298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41702
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.1639
HT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hippocampus (hippocampal formation)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.983348
keratinocyte proliferation	GO Biological Process Annotations 2015	1.0	null
SLC25A1	Pathway Commons Protein-Protein Interactions	1.0	null
FUS	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
RPL27A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K35259368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36612
SIK3	Pathway Commons Protein-Protein Interactions	1.0	null
DDX17	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VIM	Pathway Commons Protein-Protein Interactions	1.0	null
TNRC6B	Pathway Commons Protein-Protein Interactions	1.0	null
PMVK	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4221415__F5	PFOCR Pathway Figure Associations 2023	1.0	null
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34649
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042837
RPS24	Pathway Commons Protein-Protein Interactions	1.0	null
PTEN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0054503
Hnf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.7918
496100349_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	6.48571
Lung squamous cell carcinoma_LUSC_TCGA-90-7767-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K05411364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42047
GTF3C3	Pathway Commons Protein-Protein Interactions	1.0	null
karakoline-2203	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K82968130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93161
SNU213	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35372
abnormal skin appearance	MPO Gene-Phenotype Associations	1.0	null
CORO1B	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8025515-12859_2021_4105_MOESM12_ESM.xlsx-PW1-gene_stable_id_PEG3	Rummagene Transcription Factor Associations 2026	1.0	null
PSMD12	Pathway Commons Protein-Protein Interactions	1.0	null
CAV2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00809895
GTEX-QCQG-1726-SM-3GIJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.31672
RPS15A	Pathway Commons Protein-Protein Interactions	1.0	null
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.36008
BRD-K85275903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29817
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.065
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AdrenalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.54358
nucleus	GO Cellular Component Annotations 2025	1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.80846
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.04765
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
P12-ICHIKAWA	GDSC Cell Line Gene Expression Profiles	1.0	2.81602
PMC11073972-41375_2024_2232_MOESM2_ESM.xlsx-REL-13_CD7_CD1a_DEG-DEG_L2FC_1_0_FDR_0_05_REL	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-516b	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
CHL1DM	DepMap CRISPR Gene Dependency	1.0	2.11591
CLTB	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WXYG-2026-SM-4E3IY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22418
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.46682
GCN1L1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MH-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100368_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.528
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Epidermal lamellar body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.983
Retina	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.533
H1FX	Pathway Commons Protein-Protein Interactions	1.0	null
Icthyosis	DisGeNET Gene-Disease Associations	1.0	null
ALB	Pathway Commons Protein-Protein Interactions	1.0	null
IL3RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00576482
chorion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.286381
RPS14	Pathway Commons Protein-Protein Interactions	1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	1.0	1.09691
PMC9643473-Table1.xls-MAF_0_005-Gene_refGeneWithVer_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
inflorescence	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072802
GATA1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
RBMXL1	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-SI-A71Q-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K84386253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23892
Enterobactin synthetase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.269
RPS2	Pathway Commons Protein-Protein Interactions	1.0	null
regulation of epidermis development	GO Biological Process Annotations 2025	1.0	null
GTEX-U3ZH-0226-SM-3DB7B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825886
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WH7G-2326-SM-3NMBC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29271
GTEX-T5JC-0426-SM-32PLO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23212
VCL	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.24562
TTN	MSigDB Cancer Gene Co-expression Modules	1.0	null
DYNC1LI2	Pathway Commons Protein-Protein Interactions	1.0	null
RPS3	Pathway Commons Protein-Protein Interactions	1.0	null
ATAD3A	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3TX-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
vagina	HPA Tissue Protein Expression Profiles	1.0	1.63028
EIF5	Pathway Commons Protein-Protein Interactions	1.0	null
TBK1	Pathway Commons Protein-Protein Interactions	1.0	null
KYSE-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12476
NME6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0059366
DMS454	CCLE Cell Line Gene CNV Profiles	1.0	1.41496
MARK4	Pathway Commons Protein-Protein Interactions	1.0	null
YMB1	CCLE Cell Line Gene Expression Profiles	1.0	1.35621
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.0
BRD-K95264594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34768
CAMK1D	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XBEW-1526-SM-4AT4K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874783
AGRN	Pathway Commons Protein-Protein Interactions	1.0	null
DKC1	Pathway Commons Protein-Protein Interactions	1.0	null
tissue development	GO Biological Process Annotations 2015	1.0	null
MAP1LC3A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QLQ7-0008-SM-447AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874958
SETBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00694694
EWSR1_KD_GDS4962_469_human_Ewing sarcoma and prostate cancer	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K77965546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15326
GTEX-U4B1-0008-SM-4DXUW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PDCD1	MSigDB Cancer Gene Co-expression Modules	1.0	null
merocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.565232
U343	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3275
BRD-K47326075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22989
SYPL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00589679
BRD-K17232330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.202
BRD-K95578456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24938
PMC8494348-pone.0257161.s002.xlsx-D20-OXT_ext_D20-OXT_NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FLCN	Pathway Commons Protein-Protein Interactions	1.0	null
WDR5	Pathway Commons Protein-Protein Interactions	1.0	null
LARP4B	Pathway Commons Protein-Protein Interactions	1.0	null
PHF5A	Pathway Commons Protein-Protein Interactions	1.0	null
C1QBP	Pathway Commons Protein-Protein Interactions	1.0	null
IGFBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00429264
Granular corneal dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
BRD-K02837259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37921
Pigmentation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.451
Eccrine sweat gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.444
primary motor cortex (area M1, area 4)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28398
nucleus	GO Cellular Component Annotations 2015	1.0	null
SLC25A3	Pathway Commons Protein-Protein Interactions	1.0	null
Blood plasma	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.217
IQGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
Female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CCT3	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11586
BRD-K79833963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05492
GTEX-QDT8-1326-SM-48TYY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851632
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.273986
SEC61A1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q2AH-1526-SM-48TZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977161
BCKDHA	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-2964a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
GTEX-QMR6-0011-R1A-SM-32PKW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-VJWN-0126-SM-3GIK7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18025
RPL35A	Pathway Commons Protein-Protein Interactions	1.0	null
STX4	Pathway Commons Protein-Protein Interactions	1.0	null
PC-14	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-U3ZN-1026-SM-4DXTC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-U8T8-1226-SM-4E3IH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87501
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05714
CSTB	Pathway Commons Protein-Protein Interactions	1.0	null
PRKAB2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K45569026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11635
GTEX-WI4N-0726-SM-3TW93	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933017
BRD-K03067624_EMETINE HYDROCHLORIDE_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
keratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.677504
ES4	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.99766
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
XPNPEP3	Pathway Commons Protein-Protein Interactions	1.0	null
LETM2	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_2467_KO_NAT10_SRP388804	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.79155
BRD-K86073842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66702
Hair disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.642
Hemidesmosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.733
ANKRD17	Pathway Commons Protein-Protein Interactions	1.0	null
hypergranulosis	MGI Mouse Phenotype Associations 2023	1.0	null
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900566
NSUN2	Pathway Commons Protein-Protein Interactions	1.0	null
SURF4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K61370861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22077
PPIL1	Pathway Commons Protein-Protein Interactions	1.0	null
G3BP2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QDT8-0011-R4A-SM-32PKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
MDAMB436	CCLE Cell Line Gene CNV Profiles	-1.0	-1.538
PRMT1	Pathway Commons Protein-Protein Interactions	1.0	null
SJRH30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
ATP8B4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583295
ELMO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00680592
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2603
papaverine-5769	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal blistering of the skin	HPO Gene-Disease Associations	1.0	null
GTEX-XBEC-0326-SM-4AT4M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
CIC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00543935
GTEX-WI4N-0626-SM-3TW8Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943629
CCT4	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8425-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_3H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79145
PTGR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00616572
CORL279	CCLE Cell Line Gene Expression Profiles	-1.0	-2.61079
AURKB	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XLM4-2926-SM-4AT59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-PWOO-0326-SM-48TDB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952134
NQO1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.WT.HP_24H:N10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26539
corynanthine-2786	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4276
EPPK1	Pathway Commons Protein-Protein Interactions	1.0	null
CDCA4	Pathway Commons Protein-Protein Interactions	1.0	null
cytoskeletal part	GO Cellular Component Annotations 2015	1.0	null
BRD-K28728910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63655
HCC1569	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
NXF1	Pathway Commons Protein-Protein Interactions	1.0	null
Autosomal recessive congenital ichthyosis 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.345
PCMT1	Pathway Commons Protein-Protein Interactions	1.0	null
DMS79	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77301
S100A9	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K72467884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12646
GTEX-NPJ8-2626-SM-2D7W2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
IGHG2	Pathway Commons Protein-Protein Interactions	1.0	null
PTPRR	MSigDB Cancer Gene Co-expression Modules	1.0	null
ANKRD27	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0061187
BRD-K16604405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3762
EIF3E	Pathway Commons Protein-Protein Interactions	1.0	null
SNU-283	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.65954
MOV10	Pathway Commons Protein-Protein Interactions	1.0	null
SEPT9	Pathway Commons Protein-Protein Interactions	1.0	null
GTPBP4	Pathway Commons Protein-Protein Interactions	1.0	null
Atopic dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.905
MCM4	Pathway Commons Protein-Protein Interactions	1.0	null
MELK	Pathway Commons Protein-Protein Interactions	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.798958
F-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.582
XRCC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00424617
CELF2	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPU	Pathway Commons Protein-Protein Interactions	1.0	null
Subcortical maternal complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.765
PSMA6	Pathway Commons Protein-Protein Interactions	1.0	null
PYCR1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-POYW-0826-SM-2XCEM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942172
Oral mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.662
CDX2-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
buccal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.793959
TE-441-T	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.32879
DMRT1-23473982-TESTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
f2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.976
MAPK14	Pathway Commons Protein-Protein Interactions	1.0	null
EPS15L1	Pathway Commons Protein-Protein Interactions	1.0	null
Ectropion	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.692
DNAJA2	Pathway Commons Protein-Protein Interactions	1.0	null
SERPINB3	Pathway Commons Protein-Protein Interactions	1.0	null
BT474	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.73485
BZW2	Pathway Commons Protein-Protein Interactions	1.0	null
HCFC1	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9353
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04431
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06171
BRD-K23800773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66944
Rectum adenocarcinoma_READ_TCGA-BM-6198-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.03078
BRD-K50140257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06792
GTEX-W5WG-1826-SM-4KL2Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46418
Prostate adenocarcinoma_PRAD_TCGA-G9-7521-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PDHA1	Pathway Commons Protein-Protein Interactions	1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.52727
sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04298
abnormality of the skin	HPO Gene-Disease Associations	1.0	null
breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.065116
Junctional epidermolysis bullosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.669
JVE253	DepMap CRISPR Gene Dependency	1.0	3.40089
CUL5	Pathway Commons Protein-Protein Interactions	1.0	null
PPIA	Pathway Commons Protein-Protein Interactions	1.0	null
thick epidermis stratum granulosum	MGI Mouse Phenotype Associations 2023	1.0	null
NME1	Pathway Commons Protein-Protein Interactions	1.0	null
EIF3K	Pathway Commons Protein-Protein Interactions	1.0	null
DOCK7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A23955117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08484
describe	GeneRIF Biological Term Annotations	1.0	null
PPP1CA	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A856-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K79807180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02949
BRD-A52193669_2816_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RALY	Pathway Commons Protein-Protein Interactions	1.0	null
Basal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.843
BRD-K74039237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30933
PMC4221415__F5	PFOCR Pathway Figure Associations 2024	1.0	null
NDUFA2	Pathway Commons Protein-Protein Interactions	1.0	null
SMC2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RNOR-2426-SM-48FDY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PPP2R2B	Pathway Commons Protein-Protein Interactions	1.0	null
KMOE-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC9942993-pone.0281645.s002.xlsx-AR-as_all-SYMBOL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
samples	GeneRIF Biological Term Annotations	1.0	null
RAJI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MST1R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00548065
SLC35C1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00574213
PSMD1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE135400_1_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K32577562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1958
GTEX-TMMY-1026-SM-4DXTI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
NR2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
ESRRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6342
ARFGEF2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K77354700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.986
BRD-K68424387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02999
LCP1	Pathway Commons Protein-Protein Interactions	1.0	null
estradiol_homo sapiens_gpl1225_gse1486	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HTK	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46515
PSMC4	Pathway Commons Protein-Protein Interactions	1.0	null
ERG	ChEA Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.737
MEC1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.52208
NAPG	Pathway Commons Protein-Protein Interactions	1.0	null
VPS28	Pathway Commons Protein-Protein Interactions	1.0	null
GRPEL1	Pathway Commons Protein-Protein Interactions	1.0	null
RUVBL2	Pathway Commons Protein-Protein Interactions	1.0	null
RBM3	Pathway Commons Protein-Protein Interactions	1.0	null
ESR1-26153859-T47D-HUMAN-BREAST-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-QV44-1026-SM-447CG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870671
orbital frontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.39059
MSH3	MSigDB Cancer Gene Co-expression Modules	1.0	null
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.647686
PSME3	Pathway Commons Protein-Protein Interactions	1.0	null
RUVBL1	Pathway Commons Protein-Protein Interactions	1.0	null
S100A8 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.707
CSNK1A1	Pathway Commons Protein-Protein Interactions	1.0	null
ADAMTSL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00484099
positive regulation of developmental process	GO Biological Process Annotations 2025	1.0	null
EXOSC10	Pathway Commons Protein-Protein Interactions	1.0	null
RASSF5	Pathway Commons Protein-Protein Interactions	1.0	null
CCT8	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5373-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ABCB9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00825673
NCIH526	CCLE Cell Line Gene Expression Profiles	1.0	2.17215
RPS6KA1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE77178_1_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K63008302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52478
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SNRNP27	Pathway Commons Protein-Protein Interactions	1.0	null
plant embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088102
BRD-K12359218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19675
BRD-K32145037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08615
YWHAQ	Pathway Commons Protein-Protein Interactions	1.0	null
496100576_HIP_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.96419
PRPF38B	Pathway Commons Protein-Protein Interactions	1.0	null
PIK3C2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0056844
PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
KRT16	Pathway Commons Protein-Protein Interactions	1.0	null
NSDHL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00319937
UBE2N	Pathway Commons Protein-Protein Interactions	1.0	null
keratinocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.126592
FLI1	ENCODE Transcription Factor Targets	1.0	null
skin	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
piracetam-5043	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
CEACAM21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00501459
Clathrin coat of trans-Golgi network vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.763
NAPA	Pathway Commons Protein-Protein Interactions	1.0	null
HDAC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00515013
COASY	Pathway Commons Protein-Protein Interactions	1.0	null
supramolecular fiber organization	GO Biological Process Annotations 2025	1.0	null
TFG	Pathway Commons Protein-Protein Interactions	1.0	null
Ichthyosis Bullosa Of Siemens	DisGeNET Gene-Disease Associations	1.0	null
abnormal craniofacial morphology	MPO Gene-Phenotype Associations	1.0	null
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.90178
RPL18	Pathway Commons Protein-Protein Interactions	1.0	null
PSMD11	Pathway Commons Protein-Protein Interactions	1.0	null
SUZ12	ChEA Transcription Factor Targets	1.0	null
BRD-K66383189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14892
KDR	MSigDB Cancer Gene Co-expression Modules	1.0	null
HCC1428	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.54528
skin	HPA Tissue Gene Expression Profiles	1.0	2.19448
MDM2	Hub Proteins Protein-Protein Interactions	1.0	null
GTEX-S341-1726-SM-3K2AK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.51954
GTEX-WYJK-0126-SM-3NMAB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78271
pentetic acid-3387	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XGQ4-1026-SM-4AT4L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
BRD-K97468369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4892
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.01
Palate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.151
GSE218060_5_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCL	Pathway Commons Protein-Protein Interactions	1.0	null
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
NCIH1436	CCLE Cell Line Gene Expression Profiles	-1.0	-1.5264
SF1	Pathway Commons Protein-Protein Interactions	1.0	null
(-)-atenolol-6725	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
tinidazole-4370	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K90103010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39295
GEMIN5	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4481	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
TOMM34	Pathway Commons Protein-Protein Interactions	1.0	null
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
SLITRK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00454303
PRKCA	MSigDB Cancer Gene Co-expression Modules	1.0	null
NIF3L1	Pathway Commons Protein-Protein Interactions	1.0	null
Bacterial Infection_Leukocyte - Monocyte - Macrophage (MMHCC)_GSE6435	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.76988
SEC22B	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-759	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Forearm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.008
SIRT5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00716352
PCBD1	Pathway Commons Protein-Protein Interactions	1.0	null
thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.062449
membrane-bounded vesicle	GO Cellular Component Annotations 2015	1.0	null
LRRC4C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00618336
UBE2L3	Pathway Commons Protein-Protein Interactions	1.0	null
GM97	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.85332
BRD-K67689282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77483
RBMXL2	Pathway Commons Protein-Protein Interactions	1.0	null
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.86576
EIF4A1	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphoblast	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
cellular_component	GO Cellular Component Annotations 2015	1.0	null
Vitiligo	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
RBBP7	Pathway Commons Protein-Protein Interactions	1.0	null
PUS10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0051625
TNFSF14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0058011
RBM12B	Pathway Commons Protein-Protein Interactions	1.0	null
MEP1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00390864
HSPD1	Pathway Commons Protein-Protein Interactions	1.0	null
CUL1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
ESRRB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00482671
KRT82	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TML8-0926-SM-4DXSJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PDHB	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K42296822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32623
USP15	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K58382884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18004
MEC1	DepMap CRISPR Gene Dependency	1.0	3.39935
GTEX-XMD1-0526-SM-4AT4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847794
GTEX-Q2AH-0126-SM-48U2B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864663
AP2S1	Pathway Commons Protein-Protein Interactions	1.0	null
Null cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.633
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.9124
SCN5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00736982
NAA38	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-7030-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
flower	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076576
TKKK	DepMap CRISPR Gene Dependency	1.0	2.21696
DU145_PROSTATE	CCLE Cell Line Proteomics	1.0	4.17914
GTEX-R55F-0126-SM-48FCK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30789
GABARAP	Hub Proteins Protein-Protein Interactions	1.0	null
U2AF1	Pathway Commons Protein-Protein Interactions	1.0	null
ACTBL2	Pathway Commons Protein-Protein Interactions	1.0	null
RH41_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	2.99712
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
PMC12721900-jci-136-187998-s161.xlsx-Flag-ETS1_vs_vector-Gene_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
PRKAR2A	Pathway Commons Protein-Protein Interactions	1.0	null
PPP1CC	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K98560805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06124
BRD-K64859133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00008
TRPM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00632682
BRD-K42679620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13138
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21935
PSMD3	Pathway Commons Protein-Protein Interactions	1.0	null
PAK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00505549
polycystic kidney	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K14163107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3956
GSE217776,GSE217829_1_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
DLD	Pathway Commons Protein-Protein Interactions	1.0	null
RPS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0057861
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4202
abnormal corneocyte morphology	MGI Mouse Phenotype Associations 2023	1.0	null
ESYT2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6073502__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Intracellular non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
184A1N4	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.853493
Other source	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.567
GTEX-XGQ4-0526-SM-4AT6C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
Netherton syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.653
BRD-K92640680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18523
BRD-K65823297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36307
skin_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.9471
SLC5A11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572631
PMC7709111__F5	PFOCR Pathway Figure Associations 2023	1.0	null
SLC44A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00689086
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3666
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
PIK3R6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00655745
ZBTB32	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00525564
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.395
F7	Pathway Commons Protein-Protein Interactions	1.0	null
PFN2	Pathway Commons Protein-Protein Interactions	1.0	null
Chondrodysplasia punctata	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
RPL10A	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
MAP7	Pathway Commons Protein-Protein Interactions	1.0	null
Gall bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.417
GSE218060_7_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21935
PNU-0230031-3629	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RIT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00729848
hsa-miR-3679-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
SAS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EIF3B	Pathway Commons Protein-Protein Interactions	1.0	null
Scabies	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
DBN1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_2262_KO_Uhrf2_SRP105534	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.30936
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.65279
PMC12500496-262_2025_4178_MOESM2_ESM.xlsx-THP1_enriched_for_control-gene_name_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
BAG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00406968
GTEX-REY6-2126-SM-48FD9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
Hair	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.75
TTLL12	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q2AI-0926-SM-48U1F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
TRIM45	Pathway Commons Protein-Protein Interactions	1.0	null
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Atopic dermatitis 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
TUBA1C	Pathway Commons Protein-Protein Interactions	1.0	null
RPS5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K85720719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0038
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.38866
GTEX-XMD1-0011-R1A-SM-4AT4C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886787
YBX3	Pathway Commons Protein-Protein Interactions	1.0	null
movement of cell or subcellular component	GO Biological Process Annotations 2015	1.0	null
EIF5A2	Pathway Commons Protein-Protein Interactions	1.0	null
COA6	Pathway Commons Protein-Protein Interactions	1.0	null
Supramolecular polymer	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
SEC24A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QMR6-1426-SM-32PLA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
RBM7	Pathway Commons Protein-Protein Interactions	1.0	null
RAB33B	Pathway Commons Protein-Protein Interactions	1.0	null
SEMA3G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00804816
BRD-K89935890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03627
REC1	CCLE Cell Line Gene CNV Profiles	1.0	1.74495
BRD-K30214445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04943
GSE149880_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SHC1	Pathway Commons Protein-Protein Interactions	1.0	null
RBM15	Pathway Commons Protein-Protein Interactions	1.0	null
Cutaneous Paget's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
abnormal limb morphology	MPO Gene-Phenotype Associations	1.0	null
RPL7	Pathway Commons Protein-Protein Interactions	1.0	null
chorionic villus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.31332
family	GeneRIF Biological Term Annotations	1.0	null
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887867
abnormal autopod morphology	MPO Gene-Phenotype Associations	1.0	null
BRD-K38650960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22954
monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.49274
RARS	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8ID-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K96663576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10569
MATR3	Pathway Commons Protein-Protein Interactions	1.0	null
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42184
Blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.633
GTEX-S32W-2126-SM-2XCB1	GTEx Tissue Sample Gene Expression Profiles	1.0	2.82356
EW-12	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51509
GTEX-WHSE-0126-SM-3NMBT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07751
SPATA19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00688704
GSE220813_0_v_1_zfp750_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intermediate filament	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
HNRNPF	Pathway Commons Protein-Protein Interactions	1.0	null
HL60	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.65092
primary somatosensory cortex (area S1, areas 3,1,2)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.71671
SEC61B	Pathway Commons Protein-Protein Interactions	1.0	null
PTPN11	Pathway Commons Protein-Protein Interactions	1.0	null
ACSM2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00615806
NCOA5	Pathway Commons Protein-Protein Interactions	1.0	null
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9518
BRD-K19264579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18984
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T6MO-1626-SM-32QOM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17139
TFAP2A-17053090-MCF7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K23327891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34163
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.057819
BRD-K59522787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52109
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06621
BRD-K27226238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30742
nicardipine-6297	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CA SKI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
NOM1	Pathway Commons Protein-Protein Interactions	1.0	null
KE37	CCLE Cell Line Gene Expression Profiles	1.0	2.47941
PEBP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XV7Q-2526-SM-4BRV9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01092
positive regulation of epidermis development	GO Biological Process Annotations 2025	1.0	null
NCIH2106	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57721
GSE196117_1_v_11_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPL18A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K95735693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02392
aplasia/hypoplasia of the skin	HPO Gene-Disease Associations	1.0	null
MMP2	Pathway Commons Protein-Protein Interactions	1.0	null
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
PMC9668345__F3	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-A68175400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15567
SLK	Pathway Commons Protein-Protein Interactions	1.0	null
UCK2	Pathway Commons Protein-Protein Interactions	1.0	null
SLC16A1	Pathway Commons Protein-Protein Interactions	1.0	null
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.57221
BRD-K97298761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30341
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04434
GTEX-XLM4-0426-SM-4AT54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
TMEM160	Pathway Commons Protein-Protein Interactions	1.0	null
Uterine endometrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.94
GTEX-TKQ2-1226-SM-4DXSV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
TAGLN2	Pathway Commons Protein-Protein Interactions	1.0	null
salivary gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.241438
BRD-K21771537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18378
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.708
nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.979046
serine-type endopeptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.198
RPL29	Pathway Commons Protein-Protein Interactions	1.0	null
LPIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00675978
extracellular region part	GO Cellular Component Annotations 2015	1.0	null
Dental lamina	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.895
MAP1LC3B	Hub Proteins Protein-Protein Interactions	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.25858
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7515
CREB1	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-TSE9-2826-SM-4DXTF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
HIP1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76934
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PANC0213	CCLE Cell Line Gene Expression Profiles	-1.0	-2.05272
BRD-K56889360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18728
breast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061596
ZNF384_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU620	DepMap CRISPR Gene Dependency	1.0	3.25733
PMC12069319-Table1.xlsx-OCAB_p35_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
PANC1	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.02274
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4895-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DDX21	Pathway Commons Protein-Protein Interactions	1.0	null
SK-LMS-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.98757
HOP-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14932
Buccal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.221
Protease inhibitor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.175
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.5459
autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.591337
PSMG1	Pathway Commons Protein-Protein Interactions	1.0	null
ACO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0043602
GM1600	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.33408
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
ACSL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00530855
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3N5-01A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XMD1-0011-R2B-SM-4AT5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-QDVN-1126-SM-48TZ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
BRD-K35923751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0779
EBC1_LUNG	CCLE Cell Line Proteomics	1.0	3.64629
BRD-K76742876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24343
ZBED2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6669
ATP5B	Pathway Commons Protein-Protein Interactions	1.0	null
HSPA6	Pathway Commons Protein-Protein Interactions	1.0	null
HUPT3	CCLE Cell Line Gene CNV Profiles	-1.0	-2.03042
Cytoplasmic vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.858
CRK	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6971-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VTA1	Pathway Commons Protein-Protein Interactions	1.0	null
ADCK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0047813
ITPKC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00555139
GTEX-XBED-1326-SM-4AT4F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GSE218060_7_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.666
BRD-K99939253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35899
BRD-K48860650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37268
RAVER1	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5766-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PHB	Pathway Commons Protein-Protein Interactions	1.0	null
leaf epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.253248
ESR1	MSigDB Cancer Gene Co-expression Modules	1.0	null
GMDS	Pathway Commons Protein-Protein Interactions	1.0	null
SRP9	Pathway Commons Protein-Protein Interactions	1.0	null
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4124
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3N6-01A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K16238077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08645
CAOV3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58144
PMC12700831-41594_2025_1680_MOESM4_ESM.xlsx-D9_MC_Hits_2_5FC_Filtered_Out-Mapped_Gene_Symbol_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12717993-MEC-34-e17796-s002.xlsx-ST12_WGS_RFMix_genes_2_anc-Unnamed_14_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12234789-41467_2025_61560_MOESM3_ESM.xlsx-Supplementary_data_1-Only_YY1_IP-MS_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
TGM1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-O5YV-2026-SM-2D7VS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PMC12271601-mmc2.xlsx-OUT_cells_01-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WK11-2726-SM-3NMAQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08349
PMC6488577-41598_2019_43010_MOESM2_ESM.xlsx-Proteingroups_MBD3_pos-Gene_names_MBD3	Rummagene Transcription Factor Associations 2026	1.0	null
LANCL1	Pathway Commons Protein-Protein Interactions	1.0	null
CALML5	Pathway Commons Protein-Protein Interactions	1.0	null
S100A9 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.715
VSIG8	Pathway Commons Protein-Protein Interactions	1.0	null
STON2	Pathway Commons Protein-Protein Interactions	1.0	null
MTR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00690514
CDK4	Pathway Commons Protein-Protein Interactions	1.0	null
HG3	DepMap CRISPR Gene Dependency	1.0	13.503
BRD-K84601599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78303
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHWD-1826-SM-3LK6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03138
proliferation	GeneRIF Biological Term Annotations	1.0	null
CCNT1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K43684831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01954
Acute Myeloid Leukemia_LAML_TCGA-AB-2874-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XXEK-2226-SM-4BRUM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62535
abnormal kidney morphology	IMPC Knockout Mouse Phenotypes	1.0	null
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915437
RPS17	Pathway Commons Protein-Protein Interactions	1.0	null
SNRPG	Pathway Commons Protein-Protein Interactions	1.0	null
PEF1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K03254663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69133
Skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.419
GBAS	Pathway Commons Protein-Protein Interactions	1.0	null
Eosinophil Count Procedure	DisGeNET Gene-Phenotype Associations	1.0	null
PNOC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00448521
BRD-K89863047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71731
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0442
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963935
abnormal foot pad morphology	MPO Gene-Phenotype Associations	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
MOLP-8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QLQW-1126-SM-2S1Q8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28234
IRS4	Pathway Commons Protein-Protein Interactions	1.0	null
PLS3	Pathway Commons Protein-Protein Interactions	1.0	null
DHX8	Pathway Commons Protein-Protein Interactions	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KOSC-2	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.89326
PMC9643473-Table1.xls-MAF_0_005-Gene_refGenecanonical_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
ENO2	Pathway Commons Protein-Protein Interactions	1.0	null
hair	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.70845
GTEX-P44H-0226-SM-2XCEU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14081
Recessive dystrophic epidermolysis bullosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.441
BRD-K05902089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.079
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A112-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.837571
BRD-K81144230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41469
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.17
GSE253041_1_v_0_ramp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EFNA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00825464
GTEX-TMMY-0626-SM-33HBD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842505
seedling	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.088102
SFRP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00768954
Skin epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.612
PURA	Pathway Commons Protein-Protein Interactions	1.0	null
HBZ	Pathway Commons Protein-Protein Interactions	1.0	null
primary motor-sensory cortex (samples)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.846426
PLEC	Pathway Commons Protein-Protein Interactions	1.0	null
HS 578T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.90178
Mouth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
Autosomal recessive congenital ichthyosis 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.268
GTEX-N7MT-1226-SM-2D7W4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.903821
GJB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00617406
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4378
BRD-K69408624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61452
mexiletine-4338	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CHD4	ENCODE Transcription Factor Targets	1.0	null
GTEX-PLZ5-2026-SM-2S1O4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08725
BRD-A71590475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08924
abnormality of metabolism/homeostasis	HPO Gene-Disease Associations	1.0	null
PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
CORL105	CCLE Cell Line Gene CNV Profiles	-1.0	-1.90715
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059228
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.601
WT1-25993318-PODOCYTE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.633
SCN2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00584379
GAA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00290615
496100379_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.67906
HaCaT cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.201
GTEX-QDT8-0011-R5A-SM-32PKN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
DMRT1-23473982-TESTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SF-1626-SM-3K2AY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5576
GSE116930,GSE116935_3_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QDT8-0126-SM-48TZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12483
BRD-K27384243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07162
GTEX-OHPM-0426-SM-3TW8V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
RPL31	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WYVS-1626-SM-3NM9R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11393
MPP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K23440419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04289
Supramolecular fiber	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
hsa-miR-708	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
SPINK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00542442
POLR2C	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K96776591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83579
GSE114883_1_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hydrastine hydrochloride-1740	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100384_HIP_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.19565
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUMA1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X585-2426-SM-46MW2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34268
TUBA3C	Pathway Commons Protein-Protein Interactions	1.0	null
MAP4K3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00577141
BRD-K65446780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18104
PTBP1	Pathway Commons Protein-Protein Interactions	1.0	null
LS-180	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.75883
PDLIM5	Pathway Commons Protein-Protein Interactions	1.0	null
HSF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7043
increased tail pigmentation	MPO Gene-Phenotype Associations	1.0	null
SW948	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.7051
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.207529
LRBA	Pathway Commons Protein-Protein Interactions	1.0	null
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.9741
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.962977
SF3B3	Pathway Commons Protein-Protein Interactions	1.0	null
ANXA2	Pathway Commons Protein-Protein Interactions	1.0	null
HP1BP3	Pathway Commons Protein-Protein Interactions	1.0	null
496100626_FWM_no dementia_TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03231
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.026823
SIN3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00813466
KHDRBS1	Pathway Commons Protein-Protein Interactions	1.0	null
ACOT8	Pathway Commons Protein-Protein Interactions	1.0	null
CAPRIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00674802
JAM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00712373
GTEX-XGQ4-0426-SM-4AT4I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
BRD-K47087435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50905
RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.96486
GTEX-XYKS-1426-SM-4BRUO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21851
GTEX-XUJ4-2426-SM-4BOO3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28962
YWHAB	Pathway Commons Protein-Protein Interactions	1.0	null
GGH	Pathway Commons Protein-Protein Interactions	1.0	null
PI4KA	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A76K-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CYBB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00515549
mm96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.753
SNRPC	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8432-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827147
PLCG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00611088
WDR48	Pathway Commons Protein-Protein Interactions	1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.69427
gingiva	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.404039
GTEX-XGQ4-1826-SM-4AT6F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
VPS13B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00505386
Immune system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.633
PABPC4	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPK	Pathway Commons Protein-Protein Interactions	1.0	null
Embryonic structure	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
FAU	Pathway Commons Protein-Protein Interactions	1.0	null
VCAM1	Pathway Commons Protein-Protein Interactions	1.0	null
IL27RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.006862
NCIH1355	CCLE Cell Line Gene CNV Profiles	1.0	1.84426
GTEX-S32W-0726-SM-2XCBL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931073
ACTN4	Pathway Commons Protein-Protein Interactions	1.0	null
RPS6KA3	Pathway Commons Protein-Protein Interactions	1.0	null
RCC2	Pathway Commons Protein-Protein Interactions	1.0	null
G292CLONEA141B1	DepMap CRISPR Gene Dependency	1.0	3.67071
epidermal hyperplasia	MGI Mouse Phenotype Associations 2023	1.0	null
CKB	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
BRD-K04875192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66197
Lichen planus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
TNIP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00597883
FAS	MSigDB Cancer Gene Co-expression Modules	1.0	null
Endomembrane system	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.441
MCCC2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QLQ7-0826-SM-447B3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PMC7415402-oncotarget-11-2995-s004.xlsx-EWS-FLI1_Type_1_vs_Type_2-Gene_Symbol_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
NAMALWA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K69035249	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60734
P12ICHIKAWA	CCLE Cell Line Gene Expression Profiles	1.0	1.54976
Fetal Death	CTD Gene-Disease Associations	1.0	1.10596
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
RANGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
IKBKE	Pathway Commons Protein-Protein Interactions	1.0	null
CUL4B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE174498,GSE174500_3_v_4_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
F5 meningioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.093
C8orf33	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T2YK-2226-SM-32QPT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918938
BRD-K24549321	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02786
GTEX-N7MT-1026-SM-3TW8T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.909696
GTEX-NPJ8-0326-SM-2D7VV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
Supramolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
PMC7571286-tvst-9-11-16_s004.xlsx-MaxQuant_-_SRF-Unnamed_209_SRF	Rummagene Transcription Factor Associations 2026	1.0	null
KYSE270	CCLE Cell Line Gene Expression Profiles	-1.0	-2.24357
KRT73	Pathway Commons Protein-Protein Interactions	1.0	null
NFKB1	Pathway Commons Protein-Protein Interactions	1.0	null
intermediate filament	GO Cellular Component Annotations 2023	1.0	null
BRD-K18688395	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00315
SSR4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U412-0008-SM-4DXTE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PMC6073502__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
ARHGDIB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00543773
SNU719	CCLE Cell Line Gene Expression Profiles	-1.0	-1.80858
ATG3	Pathway Commons Protein-Protein Interactions	1.0	null
FSHR	MSigDB Cancer Gene Co-expression Modules	1.0	null
SLC7A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00473527
GTEX-X3Y1-2026-SM-3P5YM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08492
PMC10246347-12859_2023_5340_MOESM7_ESM.xlsx-GATA1_HDAC_PPI-Supplementary_Table_9_GATA1-HDAC2_regulatory_network_Nodes_proteins_are_represented_both_as_official_gene_names_and_taxon_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
TPI1	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	110.238
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
MDA-MB-415	GDSC Cell Line Gene Expression Profiles	1.0	2.50517
GTEX-PX3G-3026-SM-48TZR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846482
epidermis development	GO Biological Process Annotations 2025	1.0	null
BCAS2	Pathway Commons Protein-Protein Interactions	1.0	null
Epidermal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.377
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ameboidal-type cell migration	GO Biological Process Annotations 2015	1.0	null
GTEX-XMD3-0008-SM-4AT4V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-T2IS-0226-SM-32QPH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876048
Serine protease inhibitor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.182
Prostate adenocarcinoma_PRAD_TCGA-YL-A8HM-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
T24	BioGPS Cell Line Gene Expression Profiles	1.0	1.43856
HSP90AB1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A4ZT-11A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K20495487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08027
ABCF1	Pathway Commons Protein-Protein Interactions	1.0	null
Scalp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.443
bladder	GTEx Tissue Gene Expression Profiles	-1.0	-1.44788
Colorectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.667
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1-22570637-MALME-3M-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5030-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6366-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Melanophore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.557
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-A5DJ-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BOLA2	Pathway Commons Protein-Protein Interactions	1.0	null
LUC7L2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UPK5-0426-SM-3GAEK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08614
hyperpigmentation	MPO Gene-Phenotype Associations	1.0	null
SUM 149PT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.90178
CCT7	Pathway Commons Protein-Protein Interactions	1.0	null
ANGPTL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00676997
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-RNOR-0011-R9A-SM-2TF52	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835592
GTEX-X4XY-0226-SM-4E3IZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05118
GTEX-SUCS-0226-SM-32PLQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846594
DNAJA1	Pathway Commons Protein-Protein Interactions	1.0	null
integument	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
epidermolytic	GeneRIF Biological Term Annotations	1.0	null
Keratinocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.382
Edema	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K78344913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65758
HCFC2	Pathway Commons Protein-Protein Interactions	1.0	null
scaly skin	MPO Gene-Phenotype Associations	1.0	null
CLTCL1	Pathway Commons Protein-Protein Interactions	1.0	null
phenformin-21	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Serous cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.582
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900566
PSMD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00921485
BRD-K64066545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3938
PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
GBA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00528824
18722011-SuppTable2r	GeneSigDB Published Gene Signatures	1.0	null
MYO1B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K85909950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24907
KDM2B-26808549-CHIP-SEQ-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-NFK9-1726-SM-3TW8P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933612
HSC-4	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.87755
BRD-K71501826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11053
IL12B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00572573
AAMP	Pathway Commons Protein-Protein Interactions	1.0	null
TGBC52TKB	DepMap CRISPR Gene Dependency	1.0	3.15528
LSM3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K83547183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30479
JVM3	CCLE Cell Line Gene CNV Profiles	1.0	1.41229
KRT24	Pathway Commons Protein-Protein Interactions	1.0	null
AP-1 adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.764
CCND2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00835631
HMGB1	Pathway Commons Protein-Protein Interactions	1.0	null
DIMT1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QMR6-0011-R2A-SM-32PKV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33858
tail	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.434523
BRD-K16937802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19068
ULK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519525
PMC10025425-mmc3.xlsx-ADNP_CNCR1-gene_ADNP	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.50101
BRD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00518801
hsa-miR-4306	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
LRRC47	Pathway Commons Protein-Protein Interactions	1.0	null
UBASH3B	Pathway Commons Protein-Protein Interactions	1.0	null
TNK2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K58774452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40746
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPS3A	Pathway Commons Protein-Protein Interactions	1.0	null
SCNN1D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00815586
GOLGB1	Pathway Commons Protein-Protein Interactions	1.0	null
CREB1-26743006-CHIP-SEQ-LNCAP-ABL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
UNC93B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00593848
CTV-1	GDSC Cell Line Gene Expression Profiles	1.0	1.49123
BRD-K86300178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06541
kidney failure	GWASdb SNP-Disease Associations	1.0	0.366531
PIP5K1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00453348
Liver hepatocellular carcinoma_LIHC_TCGA-4R-AA8I-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QCQG-1526-SM-48U25	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
EVSA-T	GDSC Cell Line Gene Expression Profiles	1.0	1.7071
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc_7Hour_None_GSE43204	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.45974
TAL1_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849683
keratin filament	GO Cellular Component Annotations 2015	1.0	null
BRD-K40876208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13649
PDIA3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QEL4-0926-SM-3GAD1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874397
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
DDOST	Pathway Commons Protein-Protein Interactions	1.0	null
ITSN2	Pathway Commons Protein-Protein Interactions	1.0	null
SMARCC1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE171837_1_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16765
GPR141	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00710873
IFNA10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0049637
posteroventral (inferior) parietal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.897772
GTEX-UJMC-0426-SM-4IHJF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867263
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.882791
Lung squamous cell carcinoma_LUSC_TCGA-22-5480-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTSD	Pathway Commons Protein-Protein Interactions	1.0	null
NUDC	Pathway Commons Protein-Protein Interactions	1.0	null
cutaneous	GeneRIF Biological Term Annotations	1.0	null
generalized abnormality of skin	HPO Gene-Disease Associations	1.0	null
MAP1S	Pathway Commons Protein-Protein Interactions	1.0	null
ARF1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XPVG-2126-SM-4B667	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04417
NQO2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832233
Lef1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.4218
GTEX-RWSA-0526-SM-2XCBC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824051
SRSF2	Pathway Commons Protein-Protein Interactions	1.0	null
PSMC5	Pathway Commons Protein-Protein Interactions	1.0	null
polymeric cytoskeletal fiber	GO Cellular Component Annotations 2025	1.0	null
Keratohyalin granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.223
SAP30	ENCODE Transcription Factor Targets	1.0	null
HSD17B10	Pathway Commons Protein-Protein Interactions	1.0	null
TIMM50	Pathway Commons Protein-Protein Interactions	1.0	null
RPL26	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X4XX-0126-SM-3NMC2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13046
GSE164494_0_v_2_rab22a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DDX11	MSigDB Cancer Gene Co-expression Modules	1.0	null
GRAP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00768278
NCIH650	DepMap CRISPR Gene Dependency	1.0	2.11566
PXR (PXR:RXR)	MotifMap Predicted Transcription Factor Targets	1.0	null
CARM1	Pathway Commons Protein-Protein Interactions	1.0	null
SEC24B	Pathway Commons Protein-Protein Interactions	1.0	null
DARS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00596909
NUP205	Pathway Commons Protein-Protein Interactions	1.0	null
HIST3H3	Pathway Commons Protein-Protein Interactions	1.0	null
Erythema	DisGeNET Gene-Phenotype Associations	1.0	null
TMEM71	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00604537
GTEX-REY6-0926-SM-48FDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837956
GTEX-TMMY-2226-SM-4DXTN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
ATF3-27146783-CHIP-SEQ-COLON-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
GLUD1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T2IS-0126-SM-4DM6O	GTEx Tissue Sample Gene Expression Profiles	1.0	2.23196
H3K9me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NSMAF	Pathway Commons Protein-Protein Interactions	1.0	null
KRAS.KIDNEY_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6035
TNIK	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K24748087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0979
GRSF1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X5EB-2226-SM-46MW4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86262
Dermal papilla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.679
GTEX-TSE9-1226-SM-4DXTM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WQUQ-0426-SM-3MJFU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93216
SMAD3-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9067
OGT	Pathway Commons Protein-Protein Interactions	1.0	null
TRPV5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00550359
GOTO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PSMA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555087
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
TSR2	Pathway Commons Protein-Protein Interactions	1.0	null
FLNC	Pathway Commons Protein-Protein Interactions	1.0	null
EOMES	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00688412
SRRT	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC9195629-Table1.xlsx-Supplementary_Table_1-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
trichostatin A-1785	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SKA3	Pathway Commons Protein-Protein Interactions	1.0	null
NUP210	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE235234_2_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MDM2	MSigDB Cancer Gene Co-expression Modules	1.0	null
CRCGN011_HEPG2_24H:H06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5278
BRD-K78656517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3458
RERFLCMS_LUNG	CCLE Cell Line Proteomics	1.0	2.84595
BRD-K97746859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23425
GTEX-QDVN-1326-SM-48TZ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886491
cornified envelope	GO Cellular Component Annotations 2023	1.0	null
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PTK2B	Pathway Commons Protein-Protein Interactions	1.0	null
PRKAG1	Pathway Commons Protein-Protein Interactions	1.0	null
TBC1D15	Pathway Commons Protein-Protein Interactions	1.0	null
HCC15	CCLE Cell Line Gene CNV Profiles	1.0	1.70128
SMZ1	DepMap CRISPR Gene Dependency	1.0	2.3544
HYOU1	Pathway Commons Protein-Protein Interactions	1.0	null
ETV3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2626
RPL13A	Pathway Commons Protein-Protein Interactions	1.0	null
PGK1	Pathway Commons Protein-Protein Interactions	1.0	null
KRT3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-VUSG-2526-SM-4KL1V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38323
DNAJC13	Pathway Commons Protein-Protein Interactions	1.0	null
RBM25	Pathway Commons Protein-Protein Interactions	1.0	null
microcystin RR	CTD Gene-Chemical Interactions	1.0	null
keratin	GeneRIF Biological Term Annotations	1.0	null
Epidermis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTSB	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE221577_2_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HPRT1	Pathway Commons Protein-Protein Interactions	1.0	null
RPS15	Pathway Commons Protein-Protein Interactions	1.0	null
Keratin, type II	InterPro Predicted Protein Domain Annotations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H2-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.86991
PMC5889290-koni-07-04-1412909-s001.xlsx-GSC-exo_vs_Fibro-exo_stat_sign-Gene_name_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
Fibrinogen complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.232
SMAD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.010514
Skin mucus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.193
Gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.667
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8105
Autoimmune disease of musculoskeletal system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.785
MDAMB415	CCLE Cell Line Gene Expression Profiles	1.0	1.54066
extracellular vesicular exosome	GO Cellular Component Annotations 2015	1.0	null
Hair follicle bulge	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.934
SF3A3	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A82E-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABBR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00584181
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.7281
HIST1H4F	Pathway Commons Protein-Protein Interactions	1.0	null
PRPS2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
BRD-K50575036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33024
ACO2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12804025-mmc2.xlsx-LPS-Unnamed_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
SNX3	Pathway Commons Protein-Protein Interactions	1.0	null
P53-21459846-SAOS-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K53491881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0229
TACR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00715386
PMC12260418-pnas.2425984122.sd01.xlsx-TEAD4_6fraction_test_result-Unnamed_3_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
laudanosine-1741	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYL6	Pathway Commons Protein-Protein Interactions	1.0	null
Epidermolysis bullosa simplex with mottled pigmentation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.969
BRD-K93993174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79887
BRD-K88087295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52168
ALDH1A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00437888
GTEX-WRHU-2826-SM-3MJG8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0547
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38128
SBC-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-4.42136
TAL1	ENCODE Transcription Factor Targets	1.0	null
JHOS4	DepMap CRISPR Gene Dependency	1.0	2.16949
SF767	CCLE Cell Line Gene Expression Profiles	1.0	1.45227
FLNA	Pathway Commons Protein-Protein Interactions	1.0	null
P4HB	Pathway Commons Protein-Protein Interactions	1.0	null
BHLHE40	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00475156
TREX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00769515
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
GTEX-QMR6-1926-SM-32PL9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
HBG2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDT8-3026-SM-32PKB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
KRT33B	Pathway Commons Protein-Protein Interactions	1.0	null
SNAP23	Pathway Commons Protein-Protein Interactions	1.0	null
ficolin-1-rich granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.635
KCNA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0093819
hsa-miR-28-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.90178
KTN1	Pathway Commons Protein-Protein Interactions	1.0	null
DHX30	Pathway Commons Protein-Protein Interactions	1.0	null
TGM2	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100569_TCx_possible Alzheimer's disease_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.54284
eye and adnexa disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043691
PRKAB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00512449
DDX47	Pathway Commons Protein-Protein Interactions	1.0	null
ZYX	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K34297711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.728
BRD-K50162138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21577
MAPRE1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-2861	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
CRCGN017_MCF10A.TP53.M_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21212
SNRPF	Pathway Commons Protein-Protein Interactions	1.0	null
craniofacial phenotype	MPO Gene-Phenotype Associations	1.0	null
NARS	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K44975377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25195
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KIAA0368	Pathway Commons Protein-Protein Interactions	1.0	null
PIN1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4888-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRSS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00623085
BRD-K55171585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49949
CRCGN017_MCF10A.WT.HP_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00175
Epidermal nevus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.962
ALDH3A2	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus (hippocampal formation)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.00014
GTEX-TMMY-0008-SM-4DXU3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
ESYT1	Pathway Commons Protein-Protein Interactions	1.0	null
Acantholysis	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-U4B1-0926-SM-4DXUV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1413
ri1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.532
hsa-miR-548e	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Eyelid disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.272
FLG2	Pathway Commons Protein-Protein Interactions	1.0	null
skin	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
INPPL1	Pathway Commons Protein-Protein Interactions	1.0	null
integumentary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.062162
BRD-K36164005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08746
RPS23	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K45904718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44128
BRD-K67856917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18866
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Unnamed_4_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QDT8-0626-SM-48TYW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
ARPC4	Pathway Commons Protein-Protein Interactions	1.0	null
CP67-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Iris dilator muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.632
BCAP31	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4633-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
ADH1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00812871
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K13719101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14864
Keratinocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.275
ABCE1	Pathway Commons Protein-Protein Interactions	1.0	null
SNAPC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540304
3M complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.603
S100A16	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K27194553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85488
DDX42	Pathway Commons Protein-Protein Interactions	1.0	null
ACY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496619
TE1_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	4.19429
PMC10794847-mmc2.xlsx-PBRM1_KD_up-Table_S1_Differentially_expressed_genes_with_PBRM1_knockdown_in_the_progenitor_state_Related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
tonsil_8a1	HPA Tissue Sample Gene Expression Profiles	1.0	1.093
BRD-K23363278_CYT997_SW620_6.0_h_1.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K90133009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23669
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.77193
BRD-K02535446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71106
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SMAD2/3-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MRPS28	Pathway Commons Protein-Protein Interactions	1.0	null
CSF2RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0079459
NDUFA9	Pathway Commons Protein-Protein Interactions	1.0	null
MSN	Pathway Commons Protein-Protein Interactions	1.0	null
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Stratum spinosum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.358
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.94188
BRD-K56424158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2158
GTEX-PX3G-0426-SM-48U1C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
IPO4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XGQ4-0826-SM-4AT4T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862791
Urinary tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.593
DNMT1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K90325960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89474
GSE118077_7_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNRPB	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5551-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K58118393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00687
HBG1	Pathway Commons Protein-Protein Interactions	1.0	null
SKIV2L2	Pathway Commons Protein-Protein Interactions	1.0	null
YTHDF2	Pathway Commons Protein-Protein Interactions	1.0	null
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.428
SUM102PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.46016
Alopecia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.342
HERC2	Pathway Commons Protein-Protein Interactions	1.0	null
RANBP6	Pathway Commons Protein-Protein Interactions	1.0	null
HIST1H2AB	Pathway Commons Protein-Protein Interactions	1.0	null
AGFG1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QMRM-0926-SM-447BR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0011-R5A-SM-32PL7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973544
CIZ1	Pathway Commons Protein-Protein Interactions	1.0	null
DHX57	Pathway Commons Protein-Protein Interactions	1.0	null
PSMB2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A25184723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15816
intermediate filament cytoskeleton	GO Cellular Component Annotations 2025	1.0	null
BRD-K37616496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00252
RPL15	Pathway Commons Protein-Protein Interactions	1.0	null
Vesiculobullous skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.245
NOC3L	Pathway Commons Protein-Protein Interactions	1.0	null
GUCY2F	Pathway Commons Protein-Protein Interactions	1.0	null
17823660-TableS2	GeneSigDB Published Gene Signatures	1.0	null
U937	CCLE Cell Line Gene Expression Profiles	1.0	1.66831
KRT7	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H441	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.91864
LPCAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00716978
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913517
EMD	Pathway Commons Protein-Protein Interactions	1.0	null
skin cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.0627
Lung squamous cell carcinoma_LUSC_TCGA-96-A4JL-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
keratin filament	GO Cellular Component Annotations 2025	1.0	null
Subcutaneous tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.827
eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044345
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9837
SNRNP70	Pathway Commons Protein-Protein Interactions	1.0	null
LOUNH91	DepMap CRISPR Gene Dependency	1.0	3.40139
GTEX-QDT8-0011-R3A-SM-32PKR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973079
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
IPO5	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.04767
lichen planus	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.415398
hearing/vestibular/ear phenotype	MPO Gene-Phenotype Associations	1.0	null
PDCD5	Pathway Commons Protein-Protein Interactions	1.0	null
CDK16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00528315
CENPE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00716125
RAN	Pathway Commons Protein-Protein Interactions	1.0	null
GATA2-19941826-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
LLGL1	Pathway Commons Protein-Protein Interactions	1.0	null
ALDH9A1	Pathway Commons Protein-Protein Interactions	1.0	null
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
CD2AP	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:F10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44805
EVSAT	CCLE Cell Line Gene Expression Profiles	1.0	1.6972
APOB	Pathway Commons Protein-Protein Interactions	1.0	null
RNPS1	Pathway Commons Protein-Protein Interactions	1.0	null
XRCC5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K11846531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52154
Connexin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.758
Respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.678
keratin filament	GO Cellular Component Annotations 2023	1.0	null
MM253	DepMap CRISPR Gene Dependency	1.0	2.11047
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
LN340	DepMap CRISPR Gene Dependency	1.0	3.42883
KANK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00539646
MARK1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K47461610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00481
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.8197
SERPINB2	Pathway Commons Protein-Protein Interactions	1.0	null
496100358_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.39048
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
hexylcaine-5768	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ALDH2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K86716312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35308
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K69777784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37304
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
RNF212	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0067358
ATXN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549741
thick epidermis	MGI Mouse Phenotype Associations 2023	1.0	null
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42184
BRD-K63730594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08177
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973168
SUPT5H	Pathway Commons Protein-Protein Interactions	1.0	null
Intermediate filament protein	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K63996931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25739
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
STIP1	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-8216-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Golgi apparatus	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.441
GSTP1	Pathway Commons Protein-Protein Interactions	1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064601
ESD	Pathway Commons Protein-Protein Interactions	1.0	null
QARS	Pathway Commons Protein-Protein Interactions	1.0	null
POF1B	Pathway Commons Protein-Protein Interactions	1.0	null
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.7193
MYBBP1A	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S27_LF_C2_24h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
CANX	Pathway Commons Protein-Protein Interactions	1.0	null
SLR20	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51794
GTEX-QDVN-0526-SM-48TZ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842547
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.192
GTEX-S4Q7-1426-SM-3K2B9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966538
RPL23	Pathway Commons Protein-Protein Interactions	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.978
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
EEF1A1	Pathway Commons Protein-Protein Interactions	1.0	null
YAE1D1	Pathway Commons Protein-Protein Interactions	1.0	null
NAT10	Pathway Commons Protein-Protein Interactions	1.0	null
GSE76425_0_v_12_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K87141723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50366
TNPO1	Pathway Commons Protein-Protein Interactions	1.0	null
squamous epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.564833
BRD-K95913506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05733
CAT	Pathway Commons Protein-Protein Interactions	1.0	null
Lens nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.55
PU.1	MotifMap Predicted Transcription Factor Targets	1.0	null
abnormal testis morphology	MGI Mouse Phenotype Associations 2023	1.0	null
organelle part	GO Cellular Component Annotations 2015	1.0	null
skin	GTEx Tissue Gene Expression Profiles	1.0	2.18987
GTEX-U3ZM-0826-SM-4DXU6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.059703
BRD-K44139185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44741
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RNMT	Pathway Commons Protein-Protein Interactions	1.0	null
XPO5	Pathway Commons Protein-Protein Interactions	1.0	null
EIF4G1	Pathway Commons Protein-Protein Interactions	1.0	null
MDN1	Pathway Commons Protein-Protein Interactions	1.0	null
PPP1CB	Pathway Commons Protein-Protein Interactions	1.0	null
GPC6	Pathway Commons Protein-Protein Interactions	1.0	null
ARCN1	Pathway Commons Protein-Protein Interactions	1.0	null
HTATSF1	Pathway Commons Protein-Protein Interactions	1.0	null
RTCB	Pathway Commons Protein-Protein Interactions	1.0	null
EIF2AK2	Pathway Commons Protein-Protein Interactions	1.0	null
RPS9	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K73261251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94933
PCCB	Pathway Commons Protein-Protein Interactions	1.0	null
Digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.311
dihydroergocristine-1745	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HAT1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K60460300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07473
BRD-K99516890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02906
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5107-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K92124212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45959
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
GSE160817_7_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.027607
NCBP1	Pathway Commons Protein-Protein Interactions	1.0	null
RFC2	Pathway Commons Protein-Protein Interactions	1.0	null
Contact Dermatitis	DisGeNET Gene-Disease Associations	1.0	null
A3-KAW	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.47741
IGF2BP1	Pathway Commons Protein-Protein Interactions	1.0	null
LGMN	Pathway Commons Protein-Protein Interactions	1.0	null
EIF4G2	Pathway Commons Protein-Protein Interactions	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
AGO3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RWS6-2026-SM-2XCB5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38228
congenital ichthyosiform erythroderma	HPO Gene-Disease Associations	1.0	null
HCC202	CCLE Cell Line Gene Expression Profiles	1.0	1.65876
SPTAN1	Pathway Commons Protein-Protein Interactions	1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051147
PRKCI	Pathway Commons Protein-Protein Interactions	1.0	null
LAPTM5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00516608
Lymphoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.633
GDF15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00690833
MAP7D1	Pathway Commons Protein-Protein Interactions	1.0	null
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13519
17349526-Table2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-QEG5-1126-SM-33HC2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85003
RSL1D1	Pathway Commons Protein-Protein Interactions	1.0	null
ACTR2	Pathway Commons Protein-Protein Interactions	1.0	null
IARS	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12405659-CTM2-15-e70437-s001.xlsx-Supplementary_Table_5-BioGrid-interaction_protein_with_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
ATF2	MSigDB Cancer Gene Co-expression Modules	1.0	null
hair disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.502292
DDX24	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U3ZN-2326-SM-3DB7W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26923
AT6.1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.604
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.05173
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930797
CRCGN016_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.25188
SNU739	DepMap CRISPR Gene Dependency	1.0	2.58917
PWP1	Pathway Commons Protein-Protein Interactions	1.0	null
KHSRP	Pathway Commons Protein-Protein Interactions	1.0	null
FTSJ3	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-7950-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRIM41	Pathway Commons Protein-Protein Interactions	1.0	null
Mesothelioma_MESO_TCGA-SC-A6LM-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
juxtaglomerular apparatus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.942645
PC	Pathway Commons Protein-Protein Interactions	1.0	null
upper epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.834899
skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.17679
YTHDC2	Pathway Commons Protein-Protein Interactions	1.0	null
ITGAE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0036588
SRSF11	Pathway Commons Protein-Protein Interactions	1.0	null
PVR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00475493
Ulcer tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.479
Meningioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.743
LYRM7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00621457
PRKCB	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RVPU-2226-SM-2XCAQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87184
FEN1	Pathway Commons Protein-Protein Interactions	1.0	null
NXPE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00609009
intermediate filament organization	GO Biological Process Annotations 2023	1.0	null
TUBB6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00361496
RPLP2	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16477
STMN1	Pathway Commons Protein-Protein Interactions	1.0	null
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.62
ORM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00535381
PPA1	Pathway Commons Protein-Protein Interactions	1.0	null
PRRC2C	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13	Rummagene Transcription Factor Associations 2026	1.0	null
QKI	Pathway Commons Protein-Protein Interactions	1.0	null
DOK7	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-520h	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
NGF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00668555
CIP2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00726173
SKA1	Pathway Commons Protein-Protein Interactions	1.0	null
CXCR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060606
Sebum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.786
GTEX-O5YT-0326-SM-32PKA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
PMC1683566__F5	PFOCR Pathway Figure Associations 2023	1.0	null
Gingiva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.373
cell migration	GO Biological Process Annotations 2015	1.0	null
KARS	Pathway Commons Protein-Protein Interactions	1.0	null
Vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.748
vesicle	GO Cellular Component Annotations 2015	1.0	null
GTEX-QMR6-0011-R4A-SM-32PKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
APOBEC3B	Pathway Commons Protein-Protein Interactions	1.0	null
edema	HPO Gene-Disease Associations	1.0	null
GTEX-VUSG-2326-SM-4KL1U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1685
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6327
PDAP1	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus (hippocampal formation)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.49731
IGF2BP3	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-5397-01A-01R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CPNE1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-N7MT-0726-SM-3TW8S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32772
BRD-K67670670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18852
Juxtaglomerular apparatus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.549
SRY-25088423-EMBRYONIC GONADS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
SFTPD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00894631
BRD-K77601667	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10501
RAD51D	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE114883_0_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Stratum basale	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.144
VMRCLCD	CCLE Cell Line Gene CNV Profiles	1.0	2.20807
PRPF4	Pathway Commons Protein-Protein Interactions	1.0	null
DDX6	Pathway Commons Protein-Protein Interactions	1.0	null
SU-DHL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33858
BRD-K96627018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61492
TUHR10TKB	CCLE Cell Line Gene Expression Profiles	1.0	1.89882
apud cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.386273
GTEX-SIU8-0826-SM-2XCDQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856373
JHH-7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of epidermal morphology	HPO Gene-Disease Associations	1.0	null
Hair follicle outer root sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.592
COLO-320-HSR	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FBXO22	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Lung Injury_Whole blood_GSE10474	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.794
KRT5	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H441	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MRPL43	Pathway Commons Protein-Protein Interactions	1.0	null
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.13139
BRD-K63864604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19462
Intermediate filament protein, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
BLNK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00493032
inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.10441
TIAL1	Pathway Commons Protein-Protein Interactions	1.0	null
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.552815
GTEX-S7PM-0126-SM-4AD6S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59856
ZNF207	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K93051667	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30111
ZNF326	Pathway Commons Protein-Protein Interactions	1.0	null
Nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.467
SPTBN1	Pathway Commons Protein-Protein Interactions	1.0	null
PDIA6	Pathway Commons Protein-Protein Interactions	1.0	null
CCR6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00530474
Porokeratosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.409
DSG4	Pathway Commons Protein-Protein Interactions	1.0	null
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9743
HCC2218	CCLE Cell Line Gene Expression Profiles	1.0	1.45278
GTEX-UPIC-1626-SM-4IHKT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34547
GTEX-Q2AI-1326-SM-2S1PL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16052
EIF3G	Pathway Commons Protein-Protein Interactions	1.0	null
scaly skin	MGI Mouse Phenotype Associations 2023	1.0	null
NH-12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN008_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1573
PMC10025425-mmc3.xlsx-ADNP_WH-gene_ADNP	Rummagene Transcription Factor Associations 2026	1.0	null
STK4	Pathway Commons Protein-Protein Interactions	1.0	null
JUN	JASPAR Predicted Transcription Factor Targets	1.0	null
AURKA	Pathway Commons Protein-Protein Interactions	1.0	null
MDA-MB-361	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-NFK9-0226-SM-2HMKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53683
SLC25A13	Pathway Commons Protein-Protein Interactions	1.0	null
PIGK	Pathway Commons Protein-Protein Interactions	1.0	null
TCP1	Pathway Commons Protein-Protein Interactions	1.0	null