association dataset threshold value standardized value RCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87317 GTEX-REY6-0126-SM-48FDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.02062 Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXA1_OE_GDS4957_10_human_LNCaP prostate cancer cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null paracentral lobule, posterior part, left, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.86924 ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Basal ganglion TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-XLM4-0011-R10A-SM-4AT5P GTEx Tissue Sample Gene Expression Profiles 1.0 1.00324 GSE76425_0_v_5_lenalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null RP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53666 GTEX-T5JC-0011-R7A-SM-32PME GTEx Tissue Sample Gene Expression Profiles 1.0 0.861098 PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19389 CELSR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90182 ATG9B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60037 DPYSL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4994 lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.967643 KLK8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83768 DNAAF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88968 IGLON5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44853 hsa-miR-4728-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GNAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20104 MAPRE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46468 VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.87577 hsa-miR-4505 TargetScan Predicted Conserved microRNA Targets 1.0 0.670641 METTL25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36561 TXNRD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57442 GTEX-TKQ2-1526-SM-4DXUN GTEx Tissue Sample Gene Expression Profiles 1.0 1.17544 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HTR1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.9434 Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 RFX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0117 Edinger-Westphal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.901169 BATF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.7107 ESR1-26153859-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null SP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.97547 V, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.988828 VMRCRCZ CCLE Cell Line Gene CNV Profiles -1.0 -2.16492 SKRC31 CCLE Cell Line Gene Expression Profiles 1.0 1.6903 GTEX-U8T8-0426-SM-3DB8X GTEx Tissue Sample Gene Expression Profiles 1.0 1.89936 H3K27me3_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-98-A53H-01A-12R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null RH18 CCLE Cell Line Gene CNV Profiles -1.0 -1.78234 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.48381 BATF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.5225 H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null posterior group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.39678 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q7-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELOF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03639 PMC10305740-pwac061_suppl_supplementary_table_s1.xlsx-FOXO3-knockout_bulk_RNA-seq-Unnamed_1_FOXO3 Rummagene Transcription Factor Associations 2026 1.0 null PMC12659123-12864_2025_12285_MOESM12_ESM.xlsx-Table_S12-Table_S12_Differentially_expressed_genes_after_SPI1_knockdown_SPI1 Rummagene Transcription Factor Associations 2026 1.0 null KLHL18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70287 CDX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37921 MAFA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.3821 USP25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71062 GSE224096_1_v_0_cocaine_human RummaGEO Drug Perturbation Signatures 1.0 null TRUB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.44171 PMC4905481-oncotarget-07-11397-s002.xlsx-Pinin_KD-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QVJO-0011-R2A-SM-2S1QK GTEx Tissue Sample Gene Expression Profiles 1.0 0.835525 GTL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.937419 layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.90202 CAMA1 CCLE Cell Line Gene CNV Profiles 1.0 1.51934 CLSTN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15211 THP1 DepMap CRISPR Gene Dependency 1.0 5.16564 GSE216043_11_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null NIFK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12525 GTEX-XOTO-3026-SM-4B65M GTEx Tissue Sample Gene Expression Profiles 1.0 0.995253 outer CP in midcingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.860523 SIK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67083 RPS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59842 ZFP30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.12362 H3K27me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE159678_6_v_2_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null NPM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4907 H3K27me3_H7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1913 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 orbital frontal cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.58623 rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2015 NCIH1092 CCLE Cell Line Gene Expression Profiles -1.0 -1.47941 Mesothelioma_MESO_TCGA-MQ-A4LP-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H4K20me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Stomach GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.611004 GTEX-QVUS-0011-R6A-SM-3GACX GTEx Tissue Sample Gene Expression Profiles 1.0 0.875693 occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.833989 GTEX-R55E-2526-SM-2TC6H GTEx Tissue Sample Gene Expression Profiles 1.0 0.930436 PPARGC1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83415 TTC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40629 H3K27me3_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.999448 ZFP42 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.9532 MZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15591 ARFGAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99264 CSPG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83569 DIAPH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22831 hsa-miR-3189-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 MDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44617 OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.901834 ZNF726 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00365 OTUD7B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8295 TBP ENCODE Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-6975-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIRT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80081 COQ10A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4467 NFE2L2_02_174 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.62803 GSE216043_10_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.876719 PMC7445411-CPR-53-e12862-s006.xlsx-Sheet1-Supplementary_Table_S4_Gene_expression_profiling_of_NT-MSC_and_III-MSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null thyroid_5a HPA Tissue Sample Gene Expression Profiles -1.0 -1.85091 GTEX-WHSE-0011-R8A-SM-3P5Z1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.97535 AHR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8502 lateral medullary reticular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.850587 H3C14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50218 amygdaloid complex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.54513 496100324_FWM_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.56481 PAX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17526 TMEM191C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71508 amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.70386 Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXP2 ENCODE Transcription Factor Targets 1.0 null Neostriatum TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K27me3_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NUGC-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.857972 hsa-miR-3158-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 cerebellar cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.914126 ECGI10 CCLE Cell Line Gene CNV Profiles 1.0 2.4116 Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUR-01A-21R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SYNCRIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65202 SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.28751 Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SPIC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77183 SLR20 CCLE Cell Line Gene Expression Profiles 1.0 1.89503 LHX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84531 SK-MEL-28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.869159 ZNF76 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.4652 POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ESS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90323 H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SOX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52509 STEAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79738 JMJD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20828 dorsolateral prefrontal cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.835524 HCC1419 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35205 FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11981 GLIS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 65.189 Crus I, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.03011 PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_72h_1-Unnamed_0_PDX1 Rummagene Transcription Factor Associations 2026 1.0 null COLO 794 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0254 ventrolateral prefrontal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.902066 GTEX-QDT8-0011-R1A-SM-32PKS GTEx Tissue Sample Gene Expression Profiles 1.0 0.920956 CLDN10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25381 H3K27me3_cardiac mesoderm_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-A67M-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR3C1_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOSL1::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.289 FASTK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2174 KLHL31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67319 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SA-A6C2-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHRNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8056 X, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.96028 UNKL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38826 posteroventral (inferior) parietal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.930041 NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.29235 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.46915 GMIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88218 H3K27me3_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10554 RKO-E6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07714 CNOT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64595 PF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86345 GTEX-PX3G-2026-SM-48U1H GTEx Tissue Sample Gene Expression Profiles 1.0 0.829875 GTEx Testis 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures 1.0 4.33412 CDR2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43382 LC1F CCLE Cell Line Gene Expression Profiles -1.0 -1.78874 inner SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.839845 496100571_FWM_dementia_TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.31732 V, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00516 ABI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36399 STK35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.31411 GATA3-27048872-CHIP-SEQ-THYMUS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null KLF11 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 91.5241 NES CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40166 HGS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71978 NR1D2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.3766 EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TFAP4::ETV1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.7504 Irregular astigmatism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.002 IGFBPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6322 CAL12T CCLE Cell Line Gene CNV Profiles 1.0 1.395 GSE146982_7_v_1_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-ensembl_AR Rummagene Transcription Factor Associations 2026 1.0 null MRPL36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04811 HT144 CCLE Cell Line Gene Expression Profiles -1.0 -2.08374 Bladder Urothelial Carcinoma_BLCA_TCGA-S5-A6DX-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MEIOB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14226 PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_2-1769_genes_are_more_than_four-fold_upregulated_in_PRDM8-_-_compared_to_control_PRDM8 Rummagene Transcription Factor Associations 2026 1.0 null CXADR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77458 MPV17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51393 upper (rostral) rhombic lip_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.954901 POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE176008_8_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null MAN1B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82251 anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.1062 globose nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.926164 SREBF2 JASPAR Predicted Transcription Factor Targets 1.0 null DBNDD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.31585 TMEM170A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4028 NCI-H1373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.50972 T98G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.840235 ACTN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59989 dorsal lateral geniculate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.92424 Prostate adenocarcinoma_PRAD_TCGA-V1-A8MK-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LRRC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67598 CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JC-2426-SM-3NMDB GTEx Tissue Sample Gene Expression Profiles 1.0 0.919599 GTEX-SUCS-1326-SM-4DM5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.30459 superficial layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.824975 inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.37187 SHH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52199 Esophageal squamous epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.702 TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-5280-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XAJ8-1126-SM-47JYA GTEx Tissue Sample Gene Expression Profiles 1.0 1.10852 GSE193351_1_v_2_ruxolitinib_human RummaGEO Drug Perturbation Signatures 1.0 null anterior orbital gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.852725 NCIH1581 CCLE Cell Line Gene CNV Profiles -1.0 -1.71514 Lung adenocarcinoma_LUAD_TCGA-93-A4JO-01A-21R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PKIA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32443 orbital frontal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.826235 liver_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.20061 H3K27me3_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZFP91 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64534 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.963535 NUP58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07763 PMC4021073-1471-2407-14-278-S4.xlsx-Sheet1-Supplementary_Table_S5_Genes_with_GATA3_ChIP-seq_peak_within_10kb_from_transcription_start_site_TSS_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T5JC-0011-R5A-SM-32PLK GTEx Tissue Sample Gene Expression Profiles 1.0 0.879844 VCPIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92985 ventromedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.20153 Secretory granule membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.341 GTPBP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65626 H4K20me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null liver GTEx Tissue Gene Expression Profiles -1.0 -1.15671 UCSD-242L Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35689 temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05405 stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.03388 MUSTN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62247 BCAR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62999 KLF17 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.394 BT20 CCLE Cell Line Gene CNV Profiles 1.0 2.5102 FOSL2::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.2471 SK-MEL-24 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.22717 CAL 27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.976714 PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null GTEX-P4PP-1726-SM-2S1NS GTEx Tissue Sample Gene Expression Profiles 1.0 1.12667 GTEX-OOBJ-2126-SM-3NB1N GTEx Tissue Sample Gene Expression Profiles 1.0 1.05276 MON1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24841 GTEX-QMR6-0011-R11A-SM-32PKK GTEx Tissue Sample Gene Expression Profiles 1.0 1.01383 MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DOHH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53176 HCC78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.940034 RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16423 MCEE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.41933 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7923-01A-12R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF728 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.41212 PLXNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92823 SMAD4 ChEA Transcription Factor Targets 1.0 null PGBD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36273 primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.4316 layer I of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.870706 NR3C1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SEMA3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90969 GTEX-QEG4-0126-SM-48TZE GTEx Tissue Sample Gene Expression Profiles 1.0 1.04831 ZBTB7C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.2156 UTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67743 SNU1076 CCLE Cell Line Gene Expression Profiles 1.0 1.42537 BRCA1 ENCODE Transcription Factor Targets 1.0 null TC32 CCLE Cell Line Gene Expression Profiles 1.0 2.60372 GTEX-T6MN-0326-SM-32PMK GTEx Tissue Sample Gene Expression Profiles 1.0 0.849531 RWDD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79322 GSE195559_0_v_9_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null ZSWIM9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05762 GNS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51573 GTEX-PX3G-2526-SM-48TZV GTEx Tissue Sample Gene Expression Profiles 1.0 0.939377 NABP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05339 SGF29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.35997 PARP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03587 ERF::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1208 ZNF747 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0199 RPS27L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84338 ZNF768 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.8472 PMC12092893-12672_2025_2715_MOESM1_ESM.pdf-7-TCF23_TCF23 Rummagene Transcription Factor Associations 2026 1.0 null TTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35869 tuberomammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.922978 MRPS21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93638 TXNL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24028 TRIM14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26298 hsa-miR-3197 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 BICR22 CCLE Cell Line Gene CNV Profiles 1.0 1.34259 GSE213588_8_v_11_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null TFAP2C_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.80441 globus pallidus, internal segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.30453 TAF1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.354 SMOX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61324 Lung adenocarcinoma_LUAD_TCGA-86-A4P7-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Urinary tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GTEX-QMR6-0011-R6A-SM-32PKP GTEx Tissue Sample Gene Expression Profiles 1.0 1.00259 Schnyder corneal dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.152 AHDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73785 SELENON CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60743 GTEX-XMD1-0011-R10A-SM-4AT4A GTEx Tissue Sample Gene Expression Profiles 1.0 0.906646 GTEX-QDT8-0011-R4A-SM-32PKM GTEx Tissue Sample Gene Expression Profiles 1.0 1.15708 anterior group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.30609 Lipocalin/cytosolic fatty-acid binding domain InterPro Predicted Protein Domain Annotations 1.0 null JVM3 DepMap CRISPR Gene Dependency 1.0 2.51591 HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null CD248 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90024 inferior olive, dorsal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13456 ATAD3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.45112 Calycin-like InterPro Predicted Protein Domain Annotations 1.0 null CCDC97 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19469 Bladder Urothelial Carcinoma_BLCA_TCGA-SY-A9G0-01A-12R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DYNC2I2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05314 L1236 CCLE Cell Line Gene CNV Profiles -1.0 -1.32879 UNC5D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02985 CLU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99969 heart_6a HPA Tissue Sample Gene Expression Profiles 1.0 1.09738 GTEX-WFON-2026-SM-4LVMW GTEx Tissue Sample Gene Expression Profiles 1.0 1.06018 CEP131 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20703 GSE226249_0_v_8_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PIAS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.38474 NCIH1573 CCLE Cell Line Gene CNV Profiles -1.0 -1.41962 Lung GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.596 GTEX-XMD1-2826-SM-4AT5F GTEx Tissue Sample Gene Expression Profiles 1.0 0.834411 GTEX-XGQ4-2526-SM-4AT57 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06445 GTEX-XUJ4-2726-SM-4BOQ1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09896 PMC10042887-41419_2023_5742_MOESM3_ESM.xlsx-Table_S3-Table_S3_Differently_expressed_genes_in_HOXB3_vs_HOXB3-_aPCA_HOXB3 Rummagene Transcription Factor Associations 2026 1.0 null KLHL26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50175 VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.82405 GTEX-QLQW-1426-SM-2S1QU GTEx Tissue Sample Gene Expression Profiles 1.0 0.916948 SOX8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.94505 SALE CCLE Cell Line Gene Expression Profiles 1.0 1.46639 GOLGA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67032 UBE2L5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52111 JAGN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69426 GTEX-QDT8-0011-R3A-SM-32PKR GTEx Tissue Sample Gene Expression Profiles 1.0 0.900557 CRNKL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83103 RNF17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63489 Perturb_8940_Mut_RB1_SRP220467 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -9.80048 GTEX-XBED-2526-SM-47JYD GTEx Tissue Sample Gene Expression Profiles 1.0 1.09433 ZNF253 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75306 GTEX-XBEC-0126-SM-4GIDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.32041 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7051-11A-02R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51H-06A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FM-8000-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WDR18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90108 PPIP5K2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50307 ZNF417 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94846 I-II Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.927797 THP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39712 PM20D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16632 CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null B3GNT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59135 TP53INP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.4926 NFYA ENCODE Transcription Factor Targets 1.0 null COA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71165 SURF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33968 ELOVL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91424 IL17RD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15266 LIG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68769 Forebrain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 brain_3b HPA Tissue Sample Gene Expression Profiles 1.0 1.13256 FSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89137 TRIM39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60757 GTEX-RTLS-0326-SM-2TF6A GTEx Tissue Sample Gene Expression Profiles 1.0 0.970462 SNAI3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.9815 SLC41A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57976 UTP20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96201 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RM-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GHITM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49951 496100577_FWM_probable Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.02663 TRNP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.1317 KRT8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.319 GGA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04366 GTEX-Q2AH-1926-SM-2S1PN GTEx Tissue Sample Gene Expression Profiles 1.0 1.1486 Brain Lower Grade Glioma_LGG_TCGA-S9-A6TS-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PAAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88394 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.4282 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A1A1-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.872869 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7055-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MMP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10742 PARP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21377 TSC22D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54937 BTG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31316 IREB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10373 STX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84735 posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.11402 Fallopian Tube GTEx Tissue Gene Expression Profiles 2023 1.0 2.19649 prostate_4a HPA Tissue Sample Gene Expression Profiles 1.0 1.15203 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3WY-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COX7B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97754 TGBC1TKB DepMap CRISPR Gene Dependency 1.0 3.40991 Lung squamous cell carcinoma_LUSC_TCGA-60-2715-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QVUS-2826-SM-3GADB GTEx Tissue Sample Gene Expression Profiles 1.0 1.252 RGPD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6701 NR2C1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52943 WDR46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42635 GTEX-X4XX-0011-R1B-SM-3P622 GTEx Tissue Sample Gene Expression Profiles 1.0 0.895861 ZNF611 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27981 DYRK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15694 Lung adenocarcinoma_LUAD_TCGA-55-6980-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.199971 primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.877836 MXI1 ENCODE Transcription Factor Targets 1.0 null APLN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76981 GPR37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40885 GTEX-REY6-0626-SM-2TF4G GTEx Tissue Sample Gene Expression Profiles 1.0 1.78647 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AS-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU626 CCLE Cell Line Gene CNV Profiles -1.0 -1.6066 SYT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9831 H3K27me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.840235 Corpus striatum TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A85J-01A-12R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE164874_5_v_14_prednisolone_human RummaGEO Drug Perturbation Signatures 1.0 null lateral group of nuclei, right, dorsal division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.07998 SOHLH2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0922 abducens nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.22092 IRF2BPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09493 NR1D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81774 KLF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 86.4011 PMC7594423-12915_2020_895_MOESM13_ESM.xlsx-Table_S6B-Table_S6B_-_Differentially_Expressed_genes_shared_between_BRCA_TRIM25_amp_and_Type_II_LGG_CIC_Del_CIC Rummagene Transcription Factor Associations 2026 1.0 null GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.8403 IGFBP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01027 CASP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67516 KMS20 CCLE Cell Line Gene Expression Profiles 1.0 1.88868 CYREN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98769 superior olivary complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.914073 SKMEL24 CCLE Cell Line Gene CNV Profiles -1.0 -1.51661 RAD21 ENCODE Transcription Factor Targets 1.0 null SERINC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36153 C8orf82 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35718 TCF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.9942 NHEJ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5328 H3K27me3_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HYCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55234 ZBTB24 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.3744 AGTPBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69208 GNG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20211 CREB3L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8039 OUMS23 DepMap CRISPR Gene Dependency 1.0 2.01095 GSE216757_4_v_1_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE96649_1_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null H4K20me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SCMH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12993 CORL279 CCLE Cell Line Gene Expression Profiles -1.0 -1.74862 GNRH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79704 GTEX-W5WG-2326-SM-3GIJH GTEx Tissue Sample Gene Expression Profiles 1.0 0.832139 thyroid gland HPA Tissue Gene Expression Profiles -1.0 -1.03021 PE/CA-PJ15 COSMIC Cell Line Gene CNV Profiles 1.0 3.12177 ZNF420 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4481 EDEM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91128 Acute Myeloid Leukemia_LAML_TCGA-AB-2927-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R55G-2126-SM-2TC67 GTEx Tissue Sample Gene Expression Profiles 1.0 1.3408 NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.90712 SFN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26052 DHODH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05932 PNMA8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64262 PANC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.840235 abnormality of the endocrine system GWASdb SNP-Phenotype Associations 1.0 0.171212 RKO CCLE Cell Line Gene CNV Profiles 1.0 1.69139 DCTN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68075 posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02822 PINLYP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70784 caudal subdivision of medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.5547 GTEX-PWOO-2526-SM-2S1PG GTEx Tissue Sample Gene Expression Profiles 1.0 1.14875 Lung adenocarcinoma_LUAD_TCGA-J2-A4AG-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null outer SZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.853183 GSE68925_1_v_0_fasudil_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE226249_0_v_4_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBPJL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72889 anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28934 CNOT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25986 KM12 COSMIC Cell Line Gene Mutation Profiles 1.0 null SMAD3 MotifMap Predicted Transcription Factor Targets 1.0 null CDC42EP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28326 Eye-corneal keratocyte Tabula Sapiens Gene-Cell Associations 1.0 0.304098 POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DNASE1L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33262 CMBL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41909 cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.45873 HDAC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61598 Adrenal gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 CDKN2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24986 STYX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78211 ITGA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7327 central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.32226 NR2C2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 62.9685 Lung adenocarcinoma_LUAD_TCGA-97-A4M2-01A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA2 ENCODE Transcription Factor Targets 1.0 null PDCD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.0363 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DDAH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.388 CNOT10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.585 BCAN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04989 TMEM242 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44344 GTEX-XLM4-1526-SM-4AT6D GTEx Tissue Sample Gene Expression Profiles 1.0 0.919401 E2F3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82451 SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QMR6-0011-R4A-SM-32PKU GTEx Tissue Sample Gene Expression Profiles 1.0 1.32907 ZNF703 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34724 ASPHD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05433 GTEX-NL3H-0011-R7a-SM-2I3G5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.871168 PAICS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19185 CXCL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76537 STAT6 MotifMap Predicted Transcription Factor Targets 1.0 null NR3C1_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null Small Intestine - Terminal Ileum GTEx Tissue Gene Expression Profiles 2023 1.0 1.29629 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3201 KCNQ4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18732 Brain Lower Grade Glioma_LGG_TCGA-S9-A7J2-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A97Q-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7780220-12943_2020_1301_MOESM8_ESM.xlsx-Fig_3A_RNA-seq_DEGs-Summary_701_LPS-induced_DEGs_361_THZ1-sensitive_DEGs_in_blue_of_macrophages_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null SREK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66371 H4K20me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WEY5-0826-SM-4LMIH GTEx Tissue Sample Gene Expression Profiles 1.0 1.02318 HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19496 KINGS1 DepMap CRISPR Gene Dependency 1.0 2.81666 KCNIP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27456 outer plexiform zone in extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.54653 MIOS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54914 TRA2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34052 CBLN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3936 striatum_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.927292 ATF7IP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03589 CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.963535 CCDC177 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11927 TP53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38655 GATA2_02_28 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.62803 SPRING1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79308 Sarcoma_SARC_TCGA-LI-A67I-01A-31R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anal sac TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.267 PTGES2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63084 GSE180525,GSE180528_1_v_0_tbx3_human RummaGEO Gene Perturbation Signatures 1.0 null DMS454 CCLE Cell Line Gene Expression Profiles -1.0 -2.05485 Prostate adenocarcinoma_PRAD_TCGA-EJ-A46D-01A-21R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3C2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98491 SUPT3H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77114 TNNC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.85115 CRABP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06047 globus pallidus, external segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.90605 GSE223893_11_v_10_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null ESR2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.2452 Brain Lower Grade Glioma_LGG_TCGA-TM-A84L-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HIVEP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93835 KBTBD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23411 orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.25203 MAF::NFE2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.6119 ELF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88635 GSE216043_10_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null HAX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58128 AGA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20013 CELF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85325 UQCRHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57763 ARID4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81512 FOXO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.96881 Lung squamous cell carcinoma_LUSC_TCGA-60-2726-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IKZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.0727 SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.840235 H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RT-112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.6159 GSE164874_5_v_12_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null USB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24709 OVTOKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.82266 Primary B cells from cord blood Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.6746 GSE237053_1_v_0_comt_human RummaGEO Gene Perturbation Signatures 1.0 null PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-S_72h_1-Unnamed_0_PDX1 Rummagene Transcription Factor Associations 2026 1.0 null CCNI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.49463 RTN4R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66653 GART CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49183 INSM1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.6667 COX17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33278 E2A MotifMap Predicted Transcription Factor Targets 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93Y-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01821 NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.901834 parabigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.886252 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ7-2826-SM-2I3FU GTEx Tissue Sample Gene Expression Profiles 1.0 0.825608 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.4814 GSE245270_2_v_4_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-6D-AA2E-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TSSC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21554 ATP8B3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32327 hsa-miR-324-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GTEX-TKQ1-1326-SM-4DXU7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.962941 ZC3H7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72091 ARHGEF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21672 Epididymal fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.837 H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6TX-01A-21R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A623-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.858266 Skin Cutaneous Melanoma_SKCM_TCGA-D9-A3Z3-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100532_FWM_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.59362 anterior group of nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.916298 LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39712 KCNE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24121 PPARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.2857 MICALL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2718 HSPBAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23845 GTEX-NL3H-0011-R4a-SM-2I3GK GTEx Tissue Sample Gene Expression Profiles 1.0 1.17259 COLO 201 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11981 Ovary TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OS-01A-12R-A220-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4527 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TH-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8939_Mut_RB1_SRP220467 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -17.3288 Skin Cutaneous Melanoma_SKCM_TCGA-D9-A3Z4-01A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null globose nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.991074 SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.73968 GATA2-21666600-HMVEC-HUMAN ChEA Transcription Factor Targets 2022 1.0 null KLF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27464 POR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65324 Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUS-01A-12R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBE2D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71303 SG in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.42133 GATA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26456 ZNF568 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62932 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PPP4R3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69155 FYN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25731 BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GOS3 CCLE Cell Line Gene CNV Profiles 1.0 1.41495 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null KIJK DepMap CRISPR Gene Dependency 1.0 2.6238 GRIN2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21089 GSE204929_0_v_1_ywhag_human RummaGEO Gene Perturbation Signatures -1.0 null NETO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82402 GTEX-XLM4-0011-R4B-SM-4AT5C GTEx Tissue Sample Gene Expression Profiles 1.0 1.28778 urinary system disease GWASdb SNP-Disease Associations 1.0 0.339792 RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UROS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72663 hsa-miR-3652 TargetScan Predicted Conserved microRNA Targets 1.0 0.123298 FOSL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.2063 ZNFX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19589 GSE131649_6_v_10_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null CPNE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50773 SMAD4-21799915-A2780-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null TNFRSF10A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98354 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2166 GPAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.30707 ME1 CCLE Cell Line Gene Expression Profiles 1.0 1.77288 Lung squamous cell carcinoma_LUSC_TCGA-43-A56U-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-3002-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF7L2 ENCODE Transcription Factor Targets 1.0 null HNF4G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.43707 MATR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7278 PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-S_48h_1-Unnamed_0_PDX1 Rummagene Transcription Factor Associations 2026 1.0 null FOSB::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.7749 SDF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81457 KP-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.963535 GTEX-OXRL-2126-SM-3NM98 GTEx Tissue Sample Gene Expression Profiles 1.0 0.905036 TMF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3159 GTEX-OHPK-1726-SM-48TC4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00522 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.031556 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FD-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8942_KO_RB1_SRP220467 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 internal segment of globus pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.838024 GRB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6747 HINT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80528 ERH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11025 ZNF585B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69488 NCIH1734 CCLE Cell Line Gene Expression Profiles -1.0 -1.54817 CEBPB ENCODE Transcription Factor Targets 1.0 null GSE128333_3_v_5_tcf4_human RummaGEO Gene Perturbation Signatures -1.0 null GID8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74686 FOSL1::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5341 FOS JASPAR Predicted Transcription Factor Targets 1.0 null PICK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77277 GTEX-XMK1-2026-SM-4B65K GTEx Tissue Sample Gene Expression Profiles 1.0 1.21941 TLCD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41366 TBC1D24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55832 IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.935871 Rectum adenocarcinoma_READ_TCGA-AF-2687-01A-02R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49058 AP3D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65996 GSE120612_6_v_1_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null TMEM39A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5118 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19T-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RHOT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25274 Lung squamous cell carcinoma_LUSC_TCGA-63-A5MT-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-609 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 CAL29 DepMap CRISPR Gene Dependency 1.0 4.6652 MTHFD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24669 Sperm flagellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.135 NCI-H196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.855795 GTEX-UPJH-0126-SM-4IHLL GTEx Tissue Sample Gene Expression Profiles 1.0 1.20001 IV, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.57599 Brain Lower Grade Glioma_LGG_TCGA-VW-A7QS-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PPP4R3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26442 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44R-06A-41R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE155031_5_v_1_dextran_human RummaGEO Drug Perturbation Signatures 1.0 null IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08343 SUZ12 ENCODE Transcription Factor Targets 1.0 null CRELD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15538 ZNF552 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68176 mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.45668 PMC10795826-jciinsight-8-170518-s128.xlsx-Fig_5B-Gene_Regulated_by_VDR_VDR Rummagene Transcription Factor Associations 2026 1.0 null SMO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98382 GTEX-WOFM-1626-SM-3MJFX GTEx Tissue Sample Gene Expression Profiles 1.0 1.04596 hsa-miR-378g TargetScan Predicted Conserved microRNA Targets 1.0 0.248923 CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFKB1 JASPAR Predicted Transcription Factor Targets 1.0 null MARCKSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21782 IFIH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36832 YTHDF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77265 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.937419 GSE216043_10_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GATA2-21666600-HMVEC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null FAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25902 IVD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20401 SAP30 ENCODE Transcription Factor Targets 1.0 null GTEX-XLM4-3026-SM-4AT6L GTEx Tissue Sample Gene Expression Profiles 1.0 1.17253 MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01383 ventrolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.60886 GTEX-WHSE-0011-R2A-SM-3P5ZL GTEx Tissue Sample Gene Expression Profiles 1.0 0.916895 ECC12 CCLE Cell Line Gene Expression Profiles -1.0 -2.45709 GSE207514,GSE207515_1_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures -1.0 null Cerebral cortex TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE115364_0_v_1_idh3a_human RummaGEO Gene Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GF-A2C7-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HOXB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5948 PTPN23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45798 ELK1 ENCODE Transcription Factor Targets 1.0 null ZNF775 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02179 QSER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70845 ZNF708 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.0636 GTEX-NL3H-0011-R3a-SM-2I3GL GTEx Tissue Sample Gene Expression Profiles 1.0 1.02568 PMC10170086-41598_2023_34519_MOESM6_ESM.xlsx-Sheet3-The_overlapping_genes_between_significantly_co-expressed_genes_and_significantly_differentially_expressed_genes_of_BARX2_in_LIHC_BARX2 Rummagene Transcription Factor Associations 2026 1.0 null ITPKC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62407 Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE159678_6_v_7_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-T6MN-2026-SM-4DM7L GTEx Tissue Sample Gene Expression Profiles 1.0 1.19763 ZSCAN30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.46486 TFAP2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.97301 CRB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29215 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12796 SBNO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37814 ZBTB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49383 GLIS3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 68.225 IZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.892043 PFDN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86065 ARRDC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69579 primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.70261 496100484_FWM_no dementia_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.22177 ZNF750 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91298 MAPK8IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90122 496100316_TCx_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.10802 H3K27me3_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUPT11 CCLE Cell Line Gene Expression Profiles 1.0 3.40794 GTEX-QMR6-0011-R7A-SM-32PKL GTEx Tissue Sample Gene Expression Profiles 1.0 1.16852 CANT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56205 INAFM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7735 ADRB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63127 Lung-vein endothelial cell Tabula Sapiens Gene-Cell Associations 1.0 0.394794 GSE193351_1_v_9_ruxolitinib_human RummaGEO Drug Perturbation Signatures 1.0 null METTL17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3989 GXYLT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4317 QRSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16842 A253 CCLE Cell Line Gene Expression Profiles -1.0 -2.01386 LRRC32 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52963 OCI-LY-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.866508 hsa-miR-335-5p MiRTarBase microRNA Targets 1.0 null Urinary system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 NCKAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98288 MYC_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ovary_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.1796 Keratoconus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.353 RNF121 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84807 Pancreatic adenocarcinoma_PAAD_TCGA-US-A77J-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-8309-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NHEK cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.756 RASA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.33124 AM38 CCLE Cell Line Gene Expression Profiles -1.0 -2.38208 FIBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36174 DCP1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93483 ATP1B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3952 FAH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12717 GTEX-V955-1926-SM-4KL1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.07747 GTEX-W5X1-2826-SM-3GILM GTEx Tissue Sample Gene Expression Profiles 1.0 0.89312 Sarcoma_SARC_TCGA-HS-A5N8-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LRRFIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61744 GSE198794_0_v_3_usp18_human RummaGEO Gene Perturbation Signatures -1.0 null PPIP5K1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71387 SLCO4A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9602 DYNC1I2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74363 SPDEF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57663 ZNF792 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57105 NCIH211 CCLE Cell Line Gene CNV Profiles -1.0 -1.56383 BOLA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19253 INA6 DepMap CRISPR Gene Dependency 1.0 2.2894 GTEX-Q2AH-1526-SM-48TZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.01367 SPAG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46281 HNRNPH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.16852 testis_7a HPA Tissue Sample Gene Expression Profiles 1.0 1.44561 HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.865392 TCAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45263 Perturb_3687_KD_RARRES2_SRP287866 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.68436 occipital pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.996721 GTEX-RNOR-0011-R4A-SM-3GAD3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.892627 RNH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77208 PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null G3BP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3421 Lung adenocarcinoma_LUAD_TCGA-55-7574-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03259 ZNF582 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16346 olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23748 Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5J6-01A-31R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FN3K CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64767 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A94W-01A-12R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.90445 MHC class II protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.651 hypoglossal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.832499 GTEX-NPJ8-1526-SM-2D7VU GTEx Tissue Sample Gene Expression Profiles 1.0 1.00927 dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.96288 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A76A-01A-51R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PCI15A DepMap CRISPR Gene Dependency 1.0 3.84555 lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.901873 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.924123 PHTF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02544 USF2 JASPAR Predicted Transcription Factor Targets 1.0 null SKA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47899 Sperm head COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.972 YOD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87353 inner CP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08635 HMEL CCLE Cell Line Gene Expression Profiles 1.0 1.54814 Liver hepatocellular carcinoma_LIHC_TCGA-WQ-A9G7-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VMRCLCP CCLE Cell Line Gene CNV Profiles -1.0 -1.57889 ZNF658 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56136 GTEX-RM2N-1326-SM-48FCW GTEx Tissue Sample Gene Expression Profiles 1.0 1.04489 ALS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10447 Lung squamous cell carcinoma_LUSC_TCGA-51-4081-11A-01R-1758-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EYA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91784 NIPA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68454 Lung adenocarcinoma_LUAD_TCGA-MP-A4TD-01A-32R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate-fibroblast Tabula Sapiens Gene-Cell Associations 1.0 0.0320103 ZNF75D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.4454 YDJC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.2559 lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.25281 SG in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.39451 GSE193351_4_v_0_ruxolitinib_human RummaGEO Drug Perturbation Signatures 1.0 null VIIAt Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.5583 inner CP in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00237 NANS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84451 EXOSC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90244 GATA1_02_60 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.61891 TCL1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26253 RFX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1464 premotor cortex (area 6) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.00279 TNP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48036 Seminal plasma TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.161 parasubicular cortex (parasubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1663 PRDM9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 154.786 ETV2::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.6482 CRB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12061 ZNF682 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.052 NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.37721 GTEX-S95S-1526-SM-2XCDH GTEx Tissue Sample Gene Expression Profiles 1.0 0.955982 PLXND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50865 PAIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78002 GLB1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09775 UOK101 DepMap CRISPR Gene Dependency 1.0 2.70507 NFYB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86468 NFIC::TLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.4375 GTEX-XQ8I-0726-SM-4BOPU GTEx Tissue Sample Gene Expression Profiles 1.0 0.959916 hsa-miR-4292 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 CTCF-27219007-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-P44H-0011-R4A-SM-2XCEW GTEx Tissue Sample Gene Expression Profiles 1.0 1.06766 VIIIA, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.31485 DDX43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.84443 H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1IB-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SJXC-0326-SM-2XCFI GTEx Tissue Sample Gene Expression Profiles 1.0 0.979187 ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE128730_4_v_1_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-4430 TargetScan Predicted Conserved microRNA Targets 1.0 0.123298 GTEX-N7MS-0126-SM-3TW8O GTEx Tissue Sample Gene Expression Profiles 1.0 1.27623 GTEX-OHPN-0011-R5A-SM-2I5FF GTEx Tissue Sample Gene Expression Profiles 1.0 0.934888 Bronchoalveolar system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MO-2026-SM-33HB4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.830242 GSE216757_0_v_2_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null HK2 CCLE Cell Line Gene Expression Profiles 1.0 1.45366 SKA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10409 LXF-289 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.937419 MIEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6612 TXNDC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41144 GRM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61065 H3K27me3_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3TV-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nerve GTEx Tissue Gene Expression Profiles 1.0 1.39147 496100592_FWM_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.80336 DMS 273 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.840235 DUSP12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51126 dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.85031 GTEX-V955-2526-SM-4JBJG GTEx Tissue Sample Gene Expression Profiles 1.0 1.25513 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.964531 ABL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20406 ZNF285 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49043 H3K27me3_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RN64-2326-SM-48FDW GTEx Tissue Sample Gene Expression Profiles 1.0 1.62397 mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.94052 ovary_8a HPA Tissue Sample Gene Expression Profiles -1.0 -1.85091 GSE155031_6_v_0_dextran_human RummaGEO Drug Perturbation Signatures -1.0 null PHETA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42526 SKOV3 DepMap CRISPR Gene Dependency 1.0 3.03435 Ltk TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.605 testis_7f HPA Tissue Sample Gene Expression Profiles 1.0 1.18562 Skeletal Muscle Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.886388 Bronchus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 hippocampus (hippocampal formation)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.881189 medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.980328 Kidney Chromophobe_KICH_TCGA-KN-8428-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TFE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68062 PCMTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51827 EPB41L5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91821 FAIM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12272 LGR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36066 GSE213588_10_v_11_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null PMC5195898-NIHMS825571-supplement-3.xlsx-Sheet1-H1975_M1_vs_H1975_M1_CIC_reconstitution_Differential_gene_expression_CIC Rummagene Transcription Factor Associations 2026 1.0 null DECR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39099 DLGAP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18473 PLAG1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 92.3889 Duodenum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35689 GTEX-U3ZH-1526-SM-4DXV1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.41918 MAFG::NFE2L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.823 NUP133 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.35876 posteroventral (inferior) parietal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21021 N4BP2L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89074 FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.937419 TGFBR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91576 CAL-62 COSMIC Cell Line Gene Mutation Profiles 1.0 null testis_7b HPA Tissue Sample Gene Expression Profiles 1.0 1.60894 dorsorostral division of MFC (area 32) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.986307 GTEX-RNOR-0326-SM-2TF51 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04643 RCOR1 ENCODE Transcription Factor Targets 1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null ZNF530 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 98.2008 SUZ12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30196 SNX27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38994 PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-R55D-0126-SM-48FEL GTEx Tissue Sample Gene Expression Profiles 1.0 1.15225 PMC10510228-13287_2023_3481_MOESM7_ESM.xlsx-DEGs-Differentially_expressed_genes_DEGs_in_bone_marrow-derived_MSCs_from_six_human_donors_cultured_at_high_confluency_MSC-HC_versus_low_confluency_MSC-LC_MSC Rummagene Transcription Factor Associations 2026 1.0 null testis_7d HPA Tissue Sample Gene Expression Profiles 1.0 1.39434 Ganglion TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 TAPBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31524 Brain - Spinal cord (cervical c-1) GTEx Tissue Gene Expression Profiles 2023 1.0 1.27473 MARCHF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1057 CCNY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02165 H4K20me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Syntrophin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.682 RPMI7951 DepMap CRISPR Gene Dependency 1.0 3.54103 GTEX-RVPU-0011-R3A-SM-2XCAE GTEx Tissue Sample Gene Expression Profiles 1.0 1.00993 MZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.6418 Lung squamous cell carcinoma_LUSC_TCGA-85-A4PA-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRDM8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32539 ETV5::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 58.6218 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11096100-41588_2024_1714_MOESM3_ESM.xlsx-ST18-Unnamed_1_ST18 Rummagene Transcription Factor Associations 2026 1.0 null Lung adenocarcinoma_LUAD_TCGA-97-8172-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTF3C6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42295 ME1 CCLE Cell Line Gene CNV Profiles -1.0 -2.83621 JJN3 CCLE Cell Line Gene Expression Profiles 1.0 1.48459 ZEB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.3624 GATD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04696 ASPC1 DepMap CRISPR Gene Dependency 1.0 2.4009 MSI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45606 Prostate adenocarcinoma_PRAD_TCGA-VP-A879-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE226249_0_v_1_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-NL3H-0011-R1a-SM-48TDJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.30215 NR3C1 ENCODE Transcription Factor Targets 1.0 null RARA::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.2174 IDH3G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78144 FXYD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90273 C7orf50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54262 GTEX-RUSQ-2126-SM-47JXK GTEx Tissue Sample Gene Expression Profiles 1.0 1.15345 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I9-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.72111 UQCRFS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92574 GTEX-XOTO-0011-R8A-SM-4B65J GTEx Tissue Sample Gene Expression Profiles 1.0 0.934581 GTEX-UPJH-0626-SM-4IHJN GTEx Tissue Sample Gene Expression Profiles 1.0 1.36096 hsa-miR-3663-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.082179 PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Significant_DE_genes_in_AKT1_vs_KLF4_meningiomas_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.849353 NUCB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37619 TIMM44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2015 C10orf82 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82599 GSE193351_1_v_0_ruxolitinib_human RummaGEO Drug Perturbation Signatures 1.0 null superior frontal gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.44313 POGLUT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.13533 Eye-fibroblast Tabula Sapiens Gene-Cell Associations 1.0 0.757578 HOXA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57349 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null amygdaloid complex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04525 SLC5A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68375 NB10 DepMap CRISPR Gene Dependency 1.0 3.07506 PMC11252405-41467_2024_50426_MOESM4_ESM.xlsx-Fig_S4c-CTCF_CTCF Rummagene Transcription Factor Associations 2026 1.0 null ATP2C1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63439 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YQ-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XQ3S-2726-SM-4BOP2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28919 MZ in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.941502 STBD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78429 Htk TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.911 HFE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00487 EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.866508 Lung-alveolar fibroblast Tabula Sapiens Gene-Cell Associations 1.0 -0.0586856 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A41B-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KRT18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22966 ZDHHC13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00998 PMC12586484-41598_2025_22484_MOESM2_ESM.xlsx-Supplementary_Table_1-Supplementary_Table_1_DEGs_in_ATOH8-depleted_EVT_ATOH8 Rummagene Transcription Factor Associations 2026 1.0 null ZNF740 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 118.487 HOP-92 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.877715 SERTAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28462 RBBP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91647 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MAFA_MAFA Rummagene Transcription Factor Associations 2026 1.0 null TFAP2A JASPAR Predicted Transcription Factor Targets 1.0 null PACADD161 DepMap CRISPR Gene Dependency 1.0 2.08467 GTEX-R55E-0011-R5A-SM-2TC5N GTEx Tissue Sample Gene Expression Profiles 1.0 0.850337 MARK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4655 MAN2B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45807 HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.837084 H2AK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FOXH1-21741376-EPCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Telencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K27me3_cardiac mesoderm_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA1_OE_GDS4957_144_human_LNCaP prostate cancer cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null PMC11184788-40164_2024_526_MOESM4_ESM.xls-MSC-EV_proteins-Unnamed_4_MSC Rummagene Transcription Factor Associations 2026 1.0 null ELP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84454 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H0-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PKDCC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30762 GTEX-S3XE-1526-SM-4AD5A GTEx Tissue Sample Gene Expression Profiles 1.0 0.923212 GSE216352,GSE216354_1_v_0_keap1_human RummaGEO Gene Perturbation Signatures 1.0 null COA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04559 GFER CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47354 NFE2L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01562 pancreas_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.85091 FOS ENCODE Transcription Factor Targets 1.0 null GSE128333_4_v_1_tcf4_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XLM4-0011-R8A-SM-4AT44 GTEx Tissue Sample Gene Expression Profiles 1.0 0.972241 496100497_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.40018 GSE173201_0_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null ZMPSTE24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0245 MAFK ENCODE Transcription Factor Targets 1.0 null Intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 SMARCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88841 GDPD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20222 GON7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74069 GTEX-WHSE-0011-R1A-SM-3P5ZK GTEx Tissue Sample Gene Expression Profiles 1.0 0.999802 Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUM-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HG3 DepMap CRISPR Gene Dependency 1.0 2.09468 EDNRB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1381 SNU886 DepMap CRISPR Gene Dependency 1.0 4.11053 ZNF74 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31935 PDE5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07916 Skin Cutaneous Melanoma_SKCM_TCGA-D9-A6EA-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A5BI-01A-31R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PLEKHA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55012 PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Unnamed_4_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null ALMS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21399 NR3C1_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_3686_KD_RARRES2_SRP287866 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.88236 MBD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.10047 BATF::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6116 GTEX-XLM4-0011-R2B-SM-4AT5Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.973917 DAN-G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20642 GTEX-PLZ6-1726-SM-2S1O6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.926999 amygdaloid complex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.42053 Lung squamous cell carcinoma_LUSC_TCGA-98-A53C-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CUL7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44457 GTEX-P44H-0526-SM-2XCF1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.868126 HCST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16578 MAFK JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.8151 OSBPL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33498 BHLHE40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.39313 GTEX-T8EM-0126-SM-4DM5R GTEx Tissue Sample Gene Expression Profiles 1.0 1.02805 TAF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48784 cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.40976 FOXE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18518 RNF213 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95653 GSE146982_7_v_1_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null MEX3D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80532 H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null E2F1 JASPAR Predicted Transcription Factor Targets 1.0 null NCIH2030 CCLE Cell Line Gene CNV Profiles -1.0 -1.82093 COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06205 cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.56712 MZT2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55249 STARD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59099 GSE216043_7_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null SLC12A9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6073 ZNF845 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96376 hsa-miR-22 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.99675 HT55 DepMap CRISPR Gene Dependency 1.0 5.74696 H3K27me3_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.14119 MYRF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23002 SIRPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79693 beta-N-acetylhexosaminidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.128 H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null AGAP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77478 ECSIT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89838 SLC35B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02703 ERGIC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75805 IZ in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.929081 DRAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67438 Corneal ectasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.011 S100A13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76555 medial portion of the shell Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.904394 Adrenocortical carcinoma_ACC_TCGA-PK-A5H9-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4TH-01A-31R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null INHA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63332 BT-20 COSMIC Cell Line Gene CNV Profiles 1.0 3.12177 METTL8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41421 INMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27823 CMAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9379 MZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25489 H4K20me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PQBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39178 20460173-ImmPortAntimicrobials GeneSigDB Published Gene Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y6-01A-21R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP in perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.40018 LLGL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41889 RARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0512 CSNK1G2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51519 FOSL1::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.2836 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A69E-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KASUMI1 CCLE Cell Line Gene Expression Profiles -1.0 -2.31919 PAIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35661 JUP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68334 Kidney TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 occipital pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -3.31005 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.43959 ASMTL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14155 GTEX-NL3H-0011-R5a-SM-2I3GB GTEx Tissue Sample Gene Expression Profiles 1.0 1.03438 GTEX-WHSE-0011-R3A-SM-3P5ZM GTEx Tissue Sample Gene Expression Profiles 1.0 0.916498 DOC2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81097 MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XGQ4-2026-SM-4AT6G GTEx Tissue Sample Gene Expression Profiles 1.0 1.09953 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44607 SAMD14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22437 NGRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85669 GTEX-QMR6-1426-SM-32PLA GTEx Tissue Sample Gene Expression Profiles 1.0 0.894787 CABLES2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.56035 TNFRSF25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18273 NKX2-2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.4413 LHX8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45208 GTEX-T5JC-0011-R4A-SM-32PLT GTEx Tissue Sample Gene Expression Profiles 1.0 0.998241 SCOC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.30805 GFUS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22953 PET100 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10244 GTEX-R55C-1426-SM-48FED GTEx Tissue Sample Gene Expression Profiles 1.0 1.26445 Lung squamous cell carcinoma_LUSC_TCGA-56-8625-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null kidney disease GWASdb SNP-Disease Associations 1.0 1.57774 NCIH1876 CCLE Cell Line Gene Expression Profiles -1.0 -1.66797 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IG-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YU-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null E2F6 JASPAR Predicted Transcription Factor Targets 1.0 null Sperm plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.492 SNU245 CCLE Cell Line Gene Expression Profiles 1.0 1.36116 MON DepMap CRISPR Gene Dependency 1.0 2.31754 HOXB13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94011 Brain Lower Grade Glioma_LGG_TCGA-DH-A66F-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF675 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.6272 VDAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98893 GTEX-QXCU-0126-SM-2TC5Q GTEx Tissue Sample Gene Expression Profiles 1.0 2.28655 GTEX-S3XE-1926-SM-3K2B3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2453 NHP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08869 LMF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26779 JHOS4 CCLE Cell Line Gene CNV Profiles -1.0 -1.38752 Sarcoma_SARC_TCGA-QQ-A5VA-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05052 GTEX-WHSB-2026-SM-3LK6H GTEx Tissue Sample Gene Expression Profiles 1.0 1.19492 MDAMB453 DepMap CRISPR Gene Dependency 1.0 5.0097 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 RAB11FIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.433 CORL311 CCLE Cell Line Gene CNV Profiles -1.0 -1.4444 GTEX-P44H-0011-R5A-SM-2XCEX GTEx Tissue Sample Gene Expression Profiles 1.0 1.11841 X Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.64459 OV56 CCLE Cell Line Gene Expression Profiles 1.0 1.49036 MAST3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37231 subgranular zone of rostral dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.80838 Acrosomal vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.067 TFAP2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 172.978 RND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3411 GATA3_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU16 DepMap CRISPR Gene Dependency 1.0 2.10597 B3GAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07339 ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09829 ACAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93467 GTEX-XLM4-2926-SM-4AT59 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0838 HELZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55233 KLM1 CCLE Cell Line Gene CNV Profiles 1.0 1.58873 PRKAA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13192 Brain Lower Grade Glioma_LGG_TCGA-DB-A4XC-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRIX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06304 Cytoplasmic vesicle lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.729 PXR, CAR, LXR, FXR MotifMap Predicted Transcription Factor Targets 1.0 null SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20642 Female accessory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.709 PRKD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3264 NR1D1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.2395 ZBTB6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.8904 IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.15264 KLF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 77.4261 POU4F3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63321 CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletal muscle HPA Tissue Protein Expression Profiles -1.0 -0.838662 ALDH3A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73839 GTEX-XMD1-0011-R3B-SM-4AT5R GTEx Tissue Sample Gene Expression Profiles 1.0 0.886652 ZNF322 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42377 SNAI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.9897 HROB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46146 HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67611 POLR2A ENCODE Transcription Factor Targets 1.0 null FOS_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAPOLA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59217 ZNF263 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6273 MZ in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.999608 GSE146982_7_v_5_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null PEER CCLE Cell Line Gene CNV Profiles -1.0 -2.15608 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20642 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBMS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10183 VPS45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99373 MUS81 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13617 Sperm head-tail coupling apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.323 BACH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3641 NDUFB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0071 caudal group of intralaminar nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.31017 KIF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91674 SOS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5664 OVCAR8 CCLE Cell Line Gene Expression Profiles -1.0 -1.50379 TSHZ3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7945 TAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18317 HCC2935 CCLE Cell Line Gene Expression Profiles -1.0 -1.82456 MX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10214 Brain Lower Grade Glioma_LGG_TCGA-DB-A75M-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-6981-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X4XX-0011-R5A-SM-46MWN GTEx Tissue Sample Gene Expression Profiles 1.0 0.835572 TTC31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19004 GTEX-UTHO-0011-R6A-SM-3GIJW GTEx Tissue Sample Gene Expression Profiles 1.0 0.904716 NFE2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.0831 GSE168797_2_v_3_cannabidiol_human RummaGEO Drug Perturbation Signatures -1.0 null Vomeronasal organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.679 Ectoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.923 LS-411N COSMIC Cell Line Gene Mutation Profiles 1.0 null JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE76425_0_v_12_lenalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null BAG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54388 PECAPJ15 CCLE Cell Line Gene CNV Profiles 1.0 2.42348 GTEX-XOTO-0326-SM-4B66K GTEx Tissue Sample Gene Expression Profiles 1.0 1.68412 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43S-01A-21R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GMEB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49397 MYC ENCODE Transcription Factor Targets 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A8P0-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null brain HPA Tissue Gene Expression Profiles 1.0 1.17551 FASLG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10088 ZFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07081 GTEX-XPT6-1626-SM-4B655 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10857 GSE118939_1_v_0_nras_human RummaGEO Gene Perturbation Signatures 1.0 null TMEM200B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36752 NPPC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09419 496100507_FWM_dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.15466 Kidney Chromophobe_KICH_TCGA-KL-8326-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA3 ENCODE Transcription Factor Targets 1.0 null TRIM61 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52862 FOS JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.0185 RETREG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51505 testis_7e HPA Tissue Sample Gene Expression Profiles 1.0 1.24149 CDAN1_02_197 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.6256 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE245270_2_v_5_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12607 MAX ENCODE Transcription Factor Targets 1.0 null GSE131649_6_v_11_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null chr9_136999551_A_G_b38 GTEx eQTL 2025 1.0 1.44107 GATA2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.42181 fastigial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.64438 LINGO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02378 GTEX-QDT8-0011-R8A-SM-32PKE GTEx Tissue Sample Gene Expression Profiles 1.0 1.21717 Lung adenocarcinoma_LUAD_TCGA-62-A46U-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PIAS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00057 GSE206729_4_v_1_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null CDK11B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72158 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE159678_6_v_3_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null TUB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55289 AP1B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62321 GATA2-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Excretory gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 KS-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.840235 REXO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02424 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A726-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.5413 brain GTEx Tissue Gene Expression Profiles 1.0 1.0226 PMC8635809-Table_2.xls-LPS-downregulated-Unnamed_4_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11849 EGR2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.4295 GTEX-R55C-1926-SM-2TF4K GTEx Tissue Sample Gene Expression Profiles 1.0 1.26021 H3K27me3_cardiac mesoderm_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null KP2 CCLE Cell Line Gene Expression Profiles -1.0 -1.49671 CEMIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81972 H4K20me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H441 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.839244 GTEX-TKQ1-0926-SM-4DXU2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.30985 KYAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96098 Eye-limbal stromal cell Tabula Sapiens Gene-Cell Associations 1.0 0.213402 orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.78194 Lung adenocarcinoma_LUAD_TCGA-55-6972-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE145990_1_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null paracentral lobule, posterior part, right, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.32734 mediodorsal nucleus of thalamus_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.902776 LN428 CCLE Cell Line Gene Expression Profiles 1.0 2.20099 Lung squamous cell carcinoma_LUSC_TCGA-98-A53D-01A-32R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LEPROT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41846 stratum pyramidale of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.4742 external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.50899 EFO-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.6159 ATP5MK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1848 soft tissue HPA Tissue Protein Expression Profiles -1.0 -0.747216 Secretory granule lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.785 hsa-miR-3064-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.062888 PFAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94744 8505C CCLE Cell Line Gene Expression Profiles -1.0 -3.04156 DUSP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19107 LN235 CCLE Cell Line Gene Expression Profiles 1.0 1.3945 MAP3K7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05967 LN340 CCLE Cell Line Gene Expression Profiles 1.0 1.86982 Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NK-01A-12R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCO2 CCLE Cell Line Gene CNV Profiles 1.0 1.42851 colonrectum_f HPA Tissue Sample Gene Expression Profiles -1.0 -1.18431 ZFAND3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57956 A172 CCLE Cell Line Gene CNV Profiles 1.0 1.66103 interpeduncular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16924 ABCG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51013 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7U8-06A-21R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE131649_6_v_5_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null ELK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42808 GTEX-N7MT-0011-R3a-SM-2I3GC GTEx Tissue Sample Gene Expression Profiles 1.0 0.994631 NSMCE4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28146 GTEX-XAJ8-1326-SM-47JYT GTEx Tissue Sample Gene Expression Profiles 1.0 1.00871 RNF34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28943 hsa-miR-4731-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.187098 Skin - Sun Exposed (Lower leg) GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.642886 NUGC4 CCLE Cell Line Gene CNV Profiles 1.0 1.5964 FBXW9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64366 MEN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54711 mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.61219 SR786 CCLE Cell Line Gene CNV Profiles -1.0 -2.11277 GTEX-QDT8-0011-R5A-SM-32PKN GTEx Tissue Sample Gene Expression Profiles 1.0 0.836836 KLF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 108.695 RBBP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.5722 NAALADL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47151 SP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09393 ZNF225 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34893 HIC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.5357 GSE199204,GSE211619_4_v_2_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null Crus II, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.866688 SETD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.58792 rostral group of intralaminar nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.03566 496100323_FWM_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.22963 POLR3D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91454 NRIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94459 Primary open angle glaucoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.003 CAOV3 CCLE Cell Line Gene CNV Profiles -1.0 -1.329 JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.964531 Small intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 OXSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83604 ZBTB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.27207 EW8 CCLE Cell Line Gene Expression Profiles 1.0 1.53248 Prostate adenocarcinoma_PRAD_TCGA-KC-A4BL-01A-31R-A250-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-S_72h_2-down-regulated_PDX1 Rummagene Transcription Factor Associations 2026 1.0 null ACD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7402 striatum_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.885732 POU2AF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76001 DDX60 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98238 LRRC61 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9286 primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.88377 EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CACNG7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97043 GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PLEKHA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28474 ZGPAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37265 H3K27me3_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCI-H2373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10287 EMC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2273 TIMMDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79672 PRRX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.246 Accessory sex gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.743 SOX17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63008 THP1 CCLE Cell Line Gene CNV Profiles 1.0 1.39417 PIAS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78495 PMC10305740-pwac061_suppl_supplementary_table_s1.xlsx-FOXO3-knockout_bulk_RNA-seq-Differentially_expressed_genes_identified_in_bulk_RNA-seq_of_FOXO3-_-_vs_FOXO3_hMyotubes_FOXO3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QMR6-0011-R10A-SM-32PKO GTEx Tissue Sample Gene Expression Profiles 1.0 0.956479 Gastrointestinal tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaD_vs_NC-Gene_ERG Rummagene Transcription Factor Associations 2026 1.0 null emboliform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.62308 Brain Lower Grade Glioma_LGG_TCGA-HT-A5RB-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PCDHGC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49595 FTSJ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06946 CAKI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.42602 GTEX-QVJO-1426-SM-2S1QY GTEx Tissue Sample Gene Expression Profiles 1.0 0.978126 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6HZ-11A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsomedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05457 MCM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49789 GTEX-RWSA-2026-SM-47JX8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10993 NCI-H2803 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.82266 GTEX-PWO3-0926-SM-2I5EY GTEx Tissue Sample Gene Expression Profiles 1.0 0.94594 GSE183327,GSE183328_3_v_0_ddit3_human RummaGEO Gene Perturbation Signatures -1.0 null MAP7D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00905 ARPC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47449 ADAMTS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01367 H3K27me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RANBP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57626 Pancreatic adenocarcinoma_PAAD_TCGA-FB-A4P5-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CCNYL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61697 SLF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38048 XPOT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86531 DDHD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77711 SND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65202 GSE216043_10_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null VSIG10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67989 H2AL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28258 outer SZ in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.36742 BICR 22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.96839 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-L4-A4E6-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC4263976-jpm-04-00282-s001.pdf-14-FOS_FOS Rummagene Transcription Factor Associations 2026 1.0 null ventrolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05993 CORL24 CCLE Cell Line Gene CNV Profiles -1.0 -1.52436 SRSF7_02_06 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.64386 EAPP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61087 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BE-01A-21R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COPE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87667 HNF4, COUP MotifMap Predicted Transcription Factor Targets 1.0 null SNU46 DepMap CRISPR Gene Dependency 1.0 2.74789 NCIH1105 CCLE Cell Line Gene Expression Profiles -1.0 -1.87688 NR3C1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPVG-2226-SM-4B65U GTEx Tissue Sample Gene Expression Profiles 1.0 1.10254 MDAMB415 CCLE Cell Line Gene CNV Profiles -1.0 -1.39828 GTEX-X4XX-3026-SM-3NMB2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.968621 Lung adenocarcinoma_LUAD_TCGA-86-8671-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null TANGO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00308 HCC515 DepMap CRISPR Gene Dependency 1.0 2.3037 Brain Lower Grade Glioma_LGG_TCGA-S9-A7IZ-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.15823 medial subdivision of central nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.63967 PNPLA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38109 iPS-20b Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.57146 TSKU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03604 GTEX-WH7G-1926-SM-4LVMM GTEx Tissue Sample Gene Expression Profiles 1.0 1.05095 hippocampus (hippocampal formation)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.29756 COPS7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43988 CP in caudal hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07077 PDLIM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32466 GTEX-NFK9-0426-SM-2YUNK GTEx Tissue Sample Gene Expression Profiles 1.0 0.95841 KML1 DepMap CRISPR Gene Dependency 1.0 3.46015 Vesicle lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.619 hsa-miR-3187-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.248923 CHGB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34995 PAQR7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32347 AFG3L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76821 SKMEL30 DepMap CRISPR Gene Dependency 1.0 2.01325 V Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.918725 CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09171 THRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.824 PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Thygro-r__CIC-1n_h-r__CIC-2n_h-r_CIC Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S7SE-0326-SM-4AT5Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.974628 MLF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53728 abducens nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.86678 H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null abnormality of circulating hormone level GWASdb SNP-Phenotype Associations 1.0 1.43889 GTEX-P44H-0011-R10A-SM-2XCEK GTEx Tissue Sample Gene Expression Profiles 1.0 1.01348 OXTR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25502 OCIMY7 DepMap CRISPR Gene Dependency 1.0 3.20235 ZNF268 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89094 HDAC6 ENCODE Transcription Factor Targets 1.0 null thyroid_5b HPA Tissue Sample Gene Expression Profiles -1.0 -0.892184 Brain - Hypothalamus GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.607253 Crus I, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.24196 GSE223893_2_v_9_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-A67S-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hippocampus (hippocampal formation)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.958744 H3K27me3_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null RELB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.896 H3K27me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RBAK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67965 H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE155031_6_v_4_dextran_human RummaGEO Drug Perturbation Signatures -1.0 null Sperm midpiece COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.11 hsa-miR-4530 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GSE131649_6_v_3_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null CFPAC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.50972 SP in entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.13722 MYO1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57953 lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04261 RC-K8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.49928 CHD2 ENCODE Transcription Factor Targets 1.0 null H3K9me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RFX5 ENCODE Transcription Factor Targets 1.0 null KPL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.23885 GSE238116_1_v_0_egr1_human RummaGEO Gene Perturbation Signatures -1.0 null CLN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9951 H3K27me3_mononuclear cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH28 DepMap CRISPR Gene Dependency 1.0 2.98743 LNCAP-CLONE-FGC COSMIC Cell Line Gene Mutation Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4TI-01A-21R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lower limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.86337 primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.39527 disease GWASdb SNP-Disease Associations 1.0 0.02949 OELE CCLE Cell Line Gene Expression Profiles 1.0 1.43673 CGB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2514 H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19P-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.329 IV, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.06906 CDA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31877 496100418_TCx_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.0525 Prostate adenocarcinoma_PRAD_TCGA-FC-A66V-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKIC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.79275 CHST14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81996 orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0551 OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.99675 Lung adenocarcinoma_LUAD_TCGA-97-A4M1-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MTMR11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5589 CDC42BPB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1989 MRAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34314 SNU1076 CCLE Cell Line Gene CNV Profiles 1.0 2.03251 TARS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38344 ASCL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.9696 Pancreatic adenocarcinoma_PAAD_TCGA-H6-A45N-11A-12R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC38A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31017 EWSR1-FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 168.629 GTEX-X4EO-0126-SM-3P5YN GTEx Tissue Sample Gene Expression Profiles 1.0 1.2558 Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DQ-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BJHTERT CCLE Cell Line Gene Expression Profiles 1.0 2.41444 ELL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33284 vagina HPA Tissue Protein Expression Profiles -1.0 -0.838662 primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.98904 MACROH2A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47862 GOLT1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6662 NCIH1623 CCLE Cell Line Gene Expression Profiles 1.0 1.36915 GSE205163,GSE205164_2_v_4_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null IGR1 CCLE Cell Line Gene CNV Profiles -1.0 -1.6748 TMEM190 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31277 H3K27me3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZM-1626-SM-4DXSK GTEx Tissue Sample Gene Expression Profiles 1.0 0.958523 GTEX-PLZ5-1526-SM-3P5ZX GTEx Tissue Sample Gene Expression Profiles 1.0 1.08195 USP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.94783 SMAD4-21799915-A2780-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Keratocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.163 TSC22D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69558 GTEX-WFG8-1926-SM-4LVM1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.899886 RPLP0 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05561 ACSF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.096 ZNF101 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58361 LPAR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12184 ZBTB7B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.1957 PSMA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73528 EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67611 GTEX-U8T8-1126-SM-4DXUE GTEx Tissue Sample Gene Expression Profiles 1.0 1.82859 T84 DepMap CRISPR Gene Dependency 1.0 3.90177 FN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82375 RHOH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19432 DPEP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63158 CORO1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71508 ZC3HC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84653 LU99 CCLE Cell Line Gene CNV Profiles 1.0 1.34259 TFAP2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 173.829 Caudate nucleus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6326-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PGBD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3781 MAF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.5621 TCF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.9257 all GWASdb SNP-Phenotype Associations 1.0 0.031501 SP9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 74.0653 GATA2_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Epididymal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.714 PITPNC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.887 PARP15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24725 VI, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.15359 GTEX-S95S-1126-SM-4B64E GTEx Tissue Sample Gene Expression Profiles 1.0 0.89493 SKRC31 CCLE Cell Line Gene CNV Profiles -1.0 -1.72749 Perturb_13978_OE_RNU11_SRP178463 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.86271 GSE146982_7_v_5_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null H4 COSMIC Cell Line Gene Mutation Profiles 1.0 null RREB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 176.455 UMRC6 CCLE Cell Line Gene Expression Profiles 1.0 1.5291 LSG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25088 ZNF341 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.2278 hsa-miR-4486 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 NCIH1755 DepMap CRISPR Gene Dependency 1.0 4.16326 RMUGS DepMap CRISPR Gene Dependency 1.0 2.14108 VASH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57152 HHV-8_72Hour_18587055_GSE6489 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.99592 PDXK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36826 ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.890586 oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.11448 inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.64575 GATA3-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1435 CCLE Cell Line Gene CNV Profiles -1.0 -1.62328 chr9_136965502_C_T_b38 GTEx eQTL 2025 1.0 2.44065 RAF1_activemutant_219_GSE42964 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.45652 GSE186739_0_v_1_asic3_human RummaGEO Gene Perturbation Signatures -1.0 null MYC_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null WBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36559 hsa-miR-1285 TargetScan Predicted Conserved microRNA Targets 1.0 0.226173 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4843-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6HX-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MARK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04578 basal ventral medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.839584 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5VU-01A-21R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TNFRSF18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14957 LDHA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70549 ATP6AP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64522 PMM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31839 superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28691 GSE131649_6_v_8_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null MGAT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03324 GSE223893_2_v_10_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.840622 PHF14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15669 SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.99559 Lung adenocarcinoma_LUAD_TCGA-05-4397-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gracile nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.40175 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4699-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DHFR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99564 NB17 DepMap CRISPR Gene Dependency 1.0 10.3012 MANBAL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.17159 hsa-miR-4261 TargetScan Predicted Conserved microRNA Targets 1.0 0.050854 Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8S1-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBC1D13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41185 CCDC28A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14572 DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.42602 LRRC58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94224 GTEX-RVPU-0011-R7A-SM-2XCAB GTEx Tissue Sample Gene Expression Profiles 1.0 1.03411 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1395 DepMap CRISPR Gene Dependency 1.0 2.25222 GSE245270_2_v_3_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null PRKX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28497 FADU CCLE Cell Line Gene CNV Profiles 1.0 1.73639 GNL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4756 ADAMTS16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47517 Adrenocortical carcinoma_ACC_TCGA-OR-A5KV-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CFPAC1 CCLE Cell Line Gene CNV Profiles -1.0 -1.62328 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-11A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MGA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1258 GTEX-X5EB-2526-SM-4E3HY GTEx Tissue Sample Gene Expression Profiles 1.0 2.27532 CISD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93094 H3K27me3_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZSCAN5C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66361 Lung adenocarcinoma_LUAD_TCGA-44-5645-11A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CITED1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64327 PROX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6782 Lung adenocarcinoma_LUAD_TCGA-86-A4P8-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null doxorubicin_homo sapiens_gpl6947_gse25741 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Alimentary canal TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PMC7806950-mmc3.xlsx-Sheet5-Table_S3_Comparison_of_DEGs_following_targeting_of_dSaCas9-repressors_to_DUX4_DUX4 Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DH-A7UV-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ASPRV1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52734 REEP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05389 TIE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26126 TAGLN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74889 Sarcoma_SARC_TCGA-DX-AB2J-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE202434,GSE202438_9_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE224096_2_v_0_cocaine_human RummaGEO Drug Perturbation Signatures 1.0 null FBXL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03132 TFAP2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 170.45 GTEX-QVJO-1325-SM-2S1QX GTEx Tissue Sample Gene Expression Profiles 1.0 0.944281 TDRKH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97979 TGIF2LY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72595 B3GNT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79999 TYSND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49819 TBC1D3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43436 GTEX-OIZI-0126-SM-3NB13 GTEx Tissue Sample Gene Expression Profiles 1.0 0.912118 PIK3CD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24736 RAD21_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cauda epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.948 GTEX-XPVG-2826-SM-4B66J GTEx Tissue Sample Gene Expression Profiles 1.0 0.863046 ZHX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77541 EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRINP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23236 pontine raphe nucleus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18923 CEBPB JASPAR Predicted Transcription Factor Targets 1.0 null Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ZBTB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33342 Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100611_FWM_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.71588 medial subdivision of area 10 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.968498 PACS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40676 TBRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5025 GSE226249_0_v_3_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null FOSL2::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.3385 amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.992018 EPB41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53089 SUN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48509 PLIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0881 SPINT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3235 MAFA MotifMap Predicted Transcription Factor Targets 1.0 null HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.840235 PMC10170086-41598_2023_34519_MOESM6_ESM.xlsx-Shee2-The_differentially_expressed_genes_between_the_BARX2_high_and_BARX2_low_group_of_LIHC_patients_BARX2 Rummagene Transcription Factor Associations 2026 1.0 null VIIAf Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.39561 ESO26 COSMIC Cell Line Gene Mutation Profiles 1.0 null ELK4 ENCODE Transcription Factor Targets 1.0 null GATA2_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPAG8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38639 NKX2-5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77096 bonemarrow_6a HPA Tissue Sample Gene Expression Profiles -1.0 -0.870833 GTEX-PWO3-1026-SM-2I5F2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.928375 RH30 DepMap CRISPR Gene Dependency 1.0 3.67342 Dry eye syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.004 Acrosomal membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.575 SUPT1 CCLE Cell Line Gene CNV Profiles -1.0 -2.64524 SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.63305 MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16131 H3K27me3_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.27362 GATA3_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DENND5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0771 EIF3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12489 mediodorsal nucleus of thalamus_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07065 SLC9A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23935 OSGIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78331 JAG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16874 mediodorsal nucleus of thalamus_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.884058 WASHC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29103 Primary hematopoietic stem cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.15906 medial geniculate complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.03697 ZNF213 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 84.5779 inferior olivary complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.24376 BARD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.6925 GTEX-S7PM-0626-SM-4AD4Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.69645 CEP250 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80918 RAD21_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FU-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EOLA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09615 WWC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78146 TRIM68 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10868 IX Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04856 BATF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7083 RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12796 PMC7806950-mmc2.xlsx-KRAB_Significant-DEGs-Table_S2_Significant_DEGs_following_targeting_of_dSaCas9-repressors_to_DUX4_DUX4 Rummagene Transcription Factor Associations 2026 1.0 null YAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40189 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07276 RAB12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38822 LRRC34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56517 NCI-H211 COSMIC Cell Line Gene Mutation Profiles 1.0 null DIPK2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52041 ZNF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 54.401 hsa-miR-4283 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 DYNC2I1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55305 NTF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69082 NCIH1876 CCLE Cell Line Gene CNV Profiles 1.0 2.08846 GTEX-WEY5-2226-SM-3GILQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.22948 TENT5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.13383 NAA20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35186 Perturb_15239_KD_ERCC6L2_SRP349996 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.7149 lymphnode_4b HPA Tissue Sample Gene Expression Profiles 1.0 0.886065 CHST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65147 SNG-M COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-R55E-0726-SM-48FCZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.78118 MRPS23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88304 Lung adenocarcinoma_LUAD_TCGA-55-7995-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FDXACB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14479 NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07584 GSE133329_2_v_3_trim28_human RummaGEO Gene Perturbation Signatures 1.0 null BLCAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.63571 VAMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87601 PE/CA-PJ15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.40369 XPR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09316 STOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64437 USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06205 G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.937419 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GK-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HMGB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16263 HCC202 CCLE Cell Line Gene Expression Profiles 1.0 1.59178 inner SZ in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.897017 SK-BR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13504 ZNF280D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13373 laterodorsal subdivision of area 8 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.830272 testis_4a HPA Tissue Sample Gene Expression Profiles 1.0 0.934353 striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08151 JUN JASPAR Predicted Transcription Factor Targets 1.0 null CPSF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95285 IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.59672 SNX21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02594 hsa-miR-4650-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.175726 CYB5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57733 Brain Lower Grade Glioma_LGG_TCGA-WY-A85D-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNOS-1126-SM-4DM67 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00817 ZIC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77284 GTEX-XUW1-0626-SM-4BOP4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06314 TFAP2A ENCODE Transcription Factor Targets 1.0 null KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.853626 GSE172146_3_v_1_mettl1_human RummaGEO Gene Perturbation Signatures 1.0 null NEIL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02442 GSE131649_6_v_0_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null EBF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.9927 MSANTD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83297 MDA-MB-453 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.61634 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.6136 PRDM16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18467 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10679 NRL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11476 USP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23107 MTRFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53975 SP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.34509 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KM-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDCA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67777 liver HPA Tissue Gene Expression Profiles -1.0 -1.13252 cuneate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.856743 TMEM50A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14279 PANK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36284 GTEX-OIZI-0426-SM-2XCEF GTEx Tissue Sample Gene Expression Profiles 1.0 0.978439 NH12 DepMap CRISPR Gene Dependency 1.0 3.05025 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZJ-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Esophagus - Mucosa GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.622256 KYSE30 CCLE Cell Line Gene CNV Profiles 1.0 1.97858 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.838945 ANXA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66846 Prostate adenocarcinoma_PRAD_TCGA-G9-6379-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNRNP25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33348 SCGB3A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72848 GSE128333_3_v_0_tcf4_human RummaGEO Gene Perturbation Signatures -1.0 null RBL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.47228 TRIO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88726 Uterine Carcinosarcoma_UCS_TCGA-N8-A4PI-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ENGASE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34746 GSE245270_1_v_4_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-S_48h_2-down-regulated_PDX1 Rummagene Transcription Factor Associations 2026 1.0 null 496100543_FWM_probable Alzheimer's disease_TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.0652 SPRY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92966 MSRB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16029 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19496 CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SF-2126-SM-3K2B2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32572 U2SURP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97599 Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-A4AQ-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H4C11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85171 Epididymosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.965 NCI-H446 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.50853 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AD-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZFP14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 73.0438 CCDC112 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30268 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-11A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GDPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63619 H3K79me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MDAMB453 CCLE Cell Line Gene CNV Profiles 1.0 1.81047 KBTBD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67722 ETFRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8002 RSL1D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43208 primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.75084 L1236 DepMap CRISPR Gene Dependency 1.0 2.46595 Meningioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.522 ZNF707 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.6197 GSE199204,GSE211619_4_v_6_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null PPP1R12A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.69088 SNUC1 DepMap CRISPR Gene Dependency 1.0 2.58249 SP8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 104.572 SNX19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78908 outer CP in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.91837 IM95 DepMap CRISPR Gene Dependency 1.0 4.44565 GSE226249_0_v_7_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null GSE196117_6_v_0_clarithromycin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X5EB-2026-SM-4E3KA GTEx Tissue Sample Gene Expression Profiles 1.0 1.06406 Brain Lower Grade Glioma_LGG_TCGA-FG-A4MX-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QDT8-2926-SM-32PKC GTEx Tissue Sample Gene Expression Profiles 1.0 1.20117 G112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.840235 H3K27me3_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.30693 CL11 CCLE Cell Line Gene Expression Profiles -1.0 -1.56833 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-XOTO-0226-SM-4B66H GTEx Tissue Sample Gene Expression Profiles 1.0 0.843884 cerebellar cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.70128 LRIG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32025 MYOD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.7917 Lung-plasmacytoid dendritic cell Tabula Sapiens Gene-Cell Associations 1.0 0.122706 DFCI024 CCLE Cell Line Gene Expression Profiles 1.0 1.9042 KPNA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34635 H3K9me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null colonrectum_d HPA Tissue Sample Gene Expression Profiles -1.0 -0.914538 GTEX-XLM4-0011-R7A-SM-4AT5L GTEx Tissue Sample Gene Expression Profiles 1.0 0.973943 TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null METTL23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93219 SMG6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50819 LRP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0923 outer CP in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20412 MNT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39309 RFX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63176 RECQL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0363 MOLM6 CCLE Cell Line Gene CNV Profiles 1.0 1.9126 SG in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.44029 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X8-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PSAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25865 HOXC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1613 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.28637 ZNF284 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96833 Human - Motor Cortex - Cluster - PVALB+ ISG20+ Layer 3-5 GABAergic neuron HuBMAP Azimuth Cell Type Annotations 1.0 null MZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04613 c-MYC_KD_GDS2526_109_human_Hela cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null COL6A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87102 H3K27me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null LN18 CCLE Cell Line Gene Expression Profiles -1.0 -1.87728 GTEX-X585-3026-SM-46MWF GTEx Tissue Sample Gene Expression Profiles 1.0 0.86898 CYBC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95826 SW1116 CCLE Cell Line Gene CNV Profiles 1.0 2.00296 ZFX_02_172 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.32193 KDM5B ENCODE Transcription Factor Targets 1.0 null ECI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69768 anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.968201 H2AFZ ENCODE Transcription Factor Targets 1.0 null ENDOG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5815 SKMM2 DepMap CRISPR Gene Dependency 1.0 2.22022 MAX_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO 857 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.998505 Prostate adenocarcinoma_PRAD_TCGA-J4-A67Q-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04603 ZNF443 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.61291 GTEX-S341-1926-SM-3K2BA GTEx Tissue Sample Gene Expression Profiles 1.0 1.22003 GSE164874_5_v_13_prednisolone_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27me3_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HLA-A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.26573 LXF289 CCLE Cell Line Gene CNV Profiles 1.0 1.43936 ELK4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCKIPSD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7055 Prostate adenocarcinoma_PRAD_TCGA-J4-A67R-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_72h_2-down-regulated_PDX1 Rummagene Transcription Factor Associations 2026 1.0 null hippocampus (hippocampal formation)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.31023 JUND ENCODE Transcription Factor Targets 1.0 null Facioscapulohumeral muscular dystrophy 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.581 H3K27me3_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNX17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54674 GSE199204,GSE211619_4_v_7_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null medial mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08762 ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null HOMER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96136 DGKA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25489 SPAST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85933 A704 CCLE Cell Line Gene CNV Profiles -1.0 -1.74288 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5VV-06A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NADK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07369 ZNF566 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39785 Lung adenocarcinoma_LUAD_TCGA-55-6969-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE245270_1_v_3_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null RKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07714 IL17RA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19504 THUMPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46398 lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.893236 Lung adenocarcinoma_LUAD_TCGA-44-6778-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A6E3-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RTL8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40874 Acute Myeloid Leukemia_LAML_TCGA-AB-2803-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14081 ARMC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18335 Human - Tonsil - L1 - Plasmacytoid dendritic HuBMAP Azimuth Cell Type Annotations 1.0 null KLHL34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94119 ERVV-1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63292 H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QMR6-0011-R5A-SM-32PKT GTEx Tissue Sample Gene Expression Profiles 1.0 1.17306 Sarcoglycan complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.665 SEPTIN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90206 ACTG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23436 lateral group of nuclei, right, ventral division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.67095 ZNF556 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.08784 GPATCH11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86556 DSN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56553 CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWSA-2426-SM-47JXR GTEx Tissue Sample Gene Expression Profiles 1.0 1.55658 Perturb_253_KD_USP18_SRP364866 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null INSIG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9587 FANCA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32228 496100516_FWM_probable Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.3032 MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.28751 dorsolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.828833 RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11849 ML-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.6159 SH3BP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50494 ZBED3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.26123 GTEX-OHPN-0011-R1A-SM-2I5GB GTEx Tissue Sample Gene Expression Profiles 1.0 0.92654 FOSL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3592 MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.865392 496100504_TCx_probable Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.08464 AKAP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3765 dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.29174 stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.824303 LNZ308 CCLE Cell Line Gene Expression Profiles 1.0 2.18262 GTEX-R55F-0226-SM-48FCI GTEx Tissue Sample Gene Expression Profiles 1.0 0.885724 ZNF382 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18596 DPF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03948 Prostate adenocarcinoma_PRAD_TCGA-J4-A83J-11A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEL9217 DepMap CRISPR Gene Dependency 1.0 3.94196 Spermatozoon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.353 GALNT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01449 GTEX-QMR6-0011-R1A-SM-32PKW GTEx Tissue Sample Gene Expression Profiles 1.0 1.3617 LCMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57526 CPT1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33717 GSE210662_3_v_1_znf165_human RummaGEO Gene Perturbation Signatures -1.0 null ALKAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84992 TSC22D4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27262 Cerebral hemisphere TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 OVTOKO CCLE Cell Line Gene Expression Profiles 1.0 1.58929 central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.64501 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.43691 ABHD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5093 MEX3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74251 VI, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.25497 inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.30232 SRRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74395 hsa-miR-1972 TargetScan Predicted Conserved microRNA Targets 1.0 0.15008 Eye-retinal pigment epithelial cell Tabula Sapiens Gene-Cell Associations 1.0 0.93897 Brain Lower Grade Glioma_LGG_TCGA-VM-A8C8-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKNSH DepMap CRISPR Gene Dependency 1.0 2.62532 rostral presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.07208 ZNF33B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01079 GTEX-SUCS-1726-SM-32PM8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.971458 HYOU1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76707 stratum pyramidale of caudal CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10699 H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.998505 Lung adenocarcinoma_LUAD_TCGA-75-7025-01A-12R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LUC7L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.122 GSE133329_0_v_3_trim28_human RummaGEO Gene Perturbation Signatures 1.0 null MED16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89232 hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.71666 pancreas GTEx Tissue Gene Expression Profiles -1.0 -0.959233 TFB2M CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82784 Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A97G-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.964531 ZNF143 ENCODE Transcription Factor Targets 1.0 null GTEX-P44H-2426-SM-2XCEJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.920692 Lung adenocarcinoma_LUAD_TCGA-38-4630-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USF2 ENCODE Transcription Factor Targets 1.0 null GALK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21164 G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01258 SNU349 CCLE Cell Line Gene CNV Profiles -1.0 -1.59808 TFAP2C ENCODE Transcription Factor Targets 1.0 null SLC30A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.43313 MUC3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88505 TRIM13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57568 Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.964531 AGL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95729 HCC2302 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.840235 GABPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.09374 GATA2-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.961637 POLR1H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22536 SLC25A51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92592 KSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36967 GFPT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44816 Facioscapulohumeral muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.254 FAM72A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86597 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A7CZ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1419 CCLE Cell Line Gene CNV Profiles 1.0 1.41198 TMEM81 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05968 GTEX-TSE9-0326-SM-3DB82 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06357 Outer acrosomal membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.122 SNRPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.3201 USF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.6706 amygdaloid complex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04548 EGR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98549 NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-WY-A858-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJMC-1926-SM-3GADS GTEx Tissue Sample Gene Expression Profiles 1.0 0.97395 NFKB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.7227 hsa-miR-612 TargetScan Predicted Conserved microRNA Targets 1.0 0.303626 stratum radiatum of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.828596 TFAP2E JASPAR Predicted Human Transcription Factor Targets 2025 1.0 55.8143 AKTIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22066 caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2267 GTEX-P44H-0011-R8A-SM-2XCEL GTEx Tissue Sample Gene Expression Profiles 1.0 1.25429 HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19301 CCNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60058 parietal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16554 SMC3 ENCODE Transcription Factor Targets 1.0 null KHM1B CCLE Cell Line Gene Expression Profiles 1.0 1.8201 NKX6-2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76716 GTEX-WHSE-2926-SM-3NMBG GTEx Tissue Sample Gene Expression Profiles 1.0 1.28687 POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ABCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61281 MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE111247_14_v_12_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null DLAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04089 GTEX-P44H-0011-R1A-SM-3NM8J GTEx Tissue Sample Gene Expression Profiles 1.0 1.41494 HELA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35205 hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.990866 SOX12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.31087 PE01 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.73968 TTLL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71007 MTPAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71141 paracentral lobule, anterior part, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.881375 DKK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60719 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-06A-22R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USP17L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3932 TMEM165 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52885 HIC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13165 COLO 320DM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.837084 Kidney Chromophobe_KICH_TCGA-KN-8434-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral group of nuclei, left, ventral division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.860899 Calycin InterPro Predicted Protein Domain Annotations 1.0 null MDAMB361 DepMap CRISPR Gene Dependency 1.0 4.53989 Brain - Cortex GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.639135 GTEX-X4EP-0011-R2B-SM-3P625 GTEx Tissue Sample Gene Expression Profiles 1.0 0.985391 NPDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87887 AKT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73399 HCC33 CCLE Cell Line Gene Expression Profiles -1.0 -2.25548 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null NDUFC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20536 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V1-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ANKRD40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05385 RBM11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9902 hippocampus (hippocampal formation)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.60455 outer SZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.858837 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.998505 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2BC13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55219 OCI-LY-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16131 EJM DepMap CRISPR Gene Dependency 1.0 2.71525 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GT-01A-12R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.57504 GSE202434,GSE202438_10_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null amygdaloid complex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08077 ATP2B4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55269 Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NH-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH2887 DepMap CRISPR Gene Dependency 1.0 4.41163 SLFN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22435 GSE245270_2_v_0_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null GSE223893_11_v_9_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null VTI1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83595 GTEX-WYJK-0326-SM-3NMA8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2048 Median body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.8 LYRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48078 RNF146 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71855 disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.036049 GSE131649_6_v_1_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null UACA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15976 Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUV-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.93153 JUND_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ASNSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66937 PGAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00628 YIPF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.6571 GATA3_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PKN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83714 Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Congenital sucrase-isomaltase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.213 GTEX-WH7G-2626-SM-3NMBE GTEx Tissue Sample Gene Expression Profiles 1.0 1.12473 NFKB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63827 CHRNB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20512 RAB33B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.11228 XRCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12926 AQP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68371 PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD Rummagene Transcription Factor Associations 2026 1.0 null DEGS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16841 HCC630 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03949 PLEKHB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61111 bonemarrow_6b HPA Tissue Sample Gene Expression Profiles -1.0 -0.892599 RNASEH2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1513 HSPH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48875 NFYA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6ES-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.904457 NCIH322 CCLE Cell Line Gene CNV Profiles 1.0 1.75069 VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.54839 layer II of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.888243 GTEX-QCQG-2026-SM-2S1PH GTEx Tissue Sample Gene Expression Profiles 1.0 0.840883 GTEX-RVPU-0011-R10A-SM-2XCAH GTEx Tissue Sample Gene Expression Profiles 1.0 1.14368 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QK-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RNF168 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59497 GATA2 ChEA Transcription Factor Targets 1.0 null MAZ ENCODE Transcription Factor Targets 1.0 null Artery - Tibial GTEx Tissue Gene Expression Profiles 2023 1.0 1.67888 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100631_PCx_dementia_TBI_77_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.2037 ABCB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60441 H3K27me3_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA3_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNRD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57071 outer SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05788 IZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.909861 HUPT4 DepMap CRISPR Gene Dependency 1.0 6.16757 GTEX-U4B1-1526-SM-4DXSL GTEx Tissue Sample Gene Expression Profiles 1.0 1.03128 OTX2_silencing_GDS4472_136_human_D425 medulloblastoma (MB) cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K27me3_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SSBP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99245 LDHD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.57969 orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.62127 NEO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07556 CTTNBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76967 VPS39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98919