association	dataset	threshold value	standardized value
UQCRHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57763
LUC7L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39472
A549_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142087
COQ5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51814
BRD-K71944937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10152
Retrosplenial area, lateral agranular part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0743
GSE242333_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC2450	DepMap CRISPR Gene Dependency	1.0	3.44138
Cecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
LU65	CCLE Cell Line Gene Expression Profiles	1.0	1.58882
mood disorder	GWASdb SNP-Disease Associations	1.0	0.321297
Lung adenocarcinoma_LUAD_TCGA-78-7166-01A-12R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNRPA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0100492
retina	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
RNF125	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14727
C2CD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10494
intermediate stratum of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
BRD-K85622666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53399
ZNF513	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59128
ZFX-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hematopoietic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06968
Prestwick-665-2186	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K03861440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14437
PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K45022385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20733
DPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98231
BRD-K40960913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33819
PDZD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8817
nucleus of the inferior collicular brachium, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39665
SOCS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8597
Fetallung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.68821
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
belongs	GeneRIF Biological Term Annotations	1.0	null
lung	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054972
TMEM86A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31676
NOS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PANC0213	CCLE Cell Line Gene CNV Profiles	-1.0	-1.89817
MED10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69586
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
Sarcoma_SARC_TCGA-DX-A3UF-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7173
C1orf56	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67029
Acute Myeloid Leukemia_LAML_TCGA-AB-2950-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SARS-CoV MA15_Day2-PFU-10^5_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.55653
PMC7064337-elife-51373-supp2.xlsx-847_genes_down-regulated-List_of_847_genes_down-regulated_after_PHF19_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE70935_2_v_4_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TMEM59L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54809
MRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47498
Birth Weight	CTD Gene-Disease Associations	1.0	1.04276
CCDC180	Pathway Commons Protein-Protein Interactions	1.0	null
GSE146982_7_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TMEM17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01882
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17401
CCDC134	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91011
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A818-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.836055
LEF1-29337183-MESC-MOUSE-STEM	ChEA Transcription Factor Targets 2022	1.0	null
Human lens epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.638
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.4917
EBF1-22473956-BONE-MARROW-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NCIH2052	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.44992
LOUCY	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HUT78	CCLE Cell Line Gene CNV Profiles	1.0	1.52722
C3orf14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43708
TAF15_02_163	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.16993
mantle zone of DgSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07571
hsa-miR-4263	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
CMK	CCLE Cell Line Gene Expression Profiles	-1.0	-1.96846
hsa-miR-3662	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.5726
CRCGN010_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24732
SLC12A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16258
dorsal periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.8724
Respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Asthma	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.822185
BRD-K87722624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54925
layer 3 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05952
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9809
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.910541
TIG3TD	CCLE Cell Line Gene Expression Profiles	-1.0	-2.5707
GSE242290_1_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lens epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.172
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
SNU308	CCLE Cell Line Gene CNV Profiles	-1.0	-2.78942
C6orf132	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84766
KRT8	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K61124142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35065
prokaryotic	GeneRIF Biological Term Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A9FL-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-ND-A4WA-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148262,GSE150691_1_v_0_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-361-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-4790-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
CRCGN014_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.57595
BRD-K51207618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57373
GSE122708,GSE123105_2_v_1_pcf11_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K99525048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25719
BRD-K53748177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.52595
spliced	GeneRIF Biological Term Annotations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5360-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_10644_KO_Gclc_SRP321080	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.4267
SH3YL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26355
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17401
Dystonia 23	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.726
leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.286026
H3K9me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A54347351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26211
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6814
Infralimbic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03231
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	0.877031
ZC4H2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18487
intermediate stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01315
eye	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
BRD-K84233319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50933
MRPL36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04811
hippocampus (hippocampal formation)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04021
POLM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56427
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.93088
BRD-A97759891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55851
inner CP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06384
mantle zone of r9BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.79341
BRD-K62852603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72463
PC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1925
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07954
epidermal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06327
PLAGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0719
ZNF354C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35692
MRPL35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88123
CNN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77791
MMAC-SF	COSMIC Cell Line Gene CNV Profiles	1.0	2.76305
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5361-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.8228
TF-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.659
CELF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35214
hsa-miR-526b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
YBX1	Pathway Commons Protein-Protein Interactions	1.0	null
lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06684
PMC4486168-pone.0131961.s006.xlsx-Sheet1-ARID3B_Upregulated_Genes_ARID3B	Rummagene Transcription Factor Associations 2026	1.0	null
PRAME	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09836
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59943
ADRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08746
KDM1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.10054
hsa-miR-4308	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
mast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.170819
hsa-miR-3942-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
ZFYVE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99046
HMX1_Deficiency_GDS4810_324_mouse_Retinas of C57BL/6J	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K92941354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06856
perimammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59878
ZMIZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86025
BRD-K05304510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04566
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HF-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.057849
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A82F-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0666
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_3_AP1_Up_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
Bed nuclei of the stria terminalis, posterior division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1114
TADA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69777
A549_BMS-911543_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170497
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	1.0	3.11756
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.78066
Perturb_1128_KO_Myc_SRP168941	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.23698
BRD-K72437469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01751
HCC202	CCLE Cell Line Gene CNV Profiles	-1.0	-2.70518
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01803
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7087
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UMUC1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.95928
Basolateral amygdalar nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
GPR20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37241
superficial stratum of r9BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.62338
CRCGN016_MCF10A.TP53.M_24H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01216
Necrosis	CTD Gene-Disease Associations	1.0	1.55353
granular layer of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34402
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.235167
ZNF563	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82976
hsa-miR-802	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21191
GJC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98627
hsa-miR-4422	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-K12107215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.954
ADAMTS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47517
disorder	GeneRIF Biological Term Annotations	1.0	null
Tear	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.665
PABPN1	Pathway Commons Protein-Protein Interactions	1.0	null
ATP6V1G1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.924
GABARAPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2442
vertebrate	GeneRIF Biological Term Annotations	1.0	null
A549_Fasudil_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129295
inner CP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17324
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
NLGN4Y	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78852
TBC1D10A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66846
hsa-miR-1224-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
ACSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84781
BRD-K50976856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28097
BRD-K56775726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28708
Lung adenocarcinoma_LUAD_TCGA-93-7348-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K94275706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19682
Multipotent progenitor cell_Stomach_Human	CellMarker Gene-Cell Type Associations	1.0	null
WDR46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42635
MZ in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.886449
PLXNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92823
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DHRS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60279
FOXQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87314
Acrosomal matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.76
GSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.4528
CCDC74A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67881
inner CP in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3882
leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073704
BRD-K45522895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11027
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF732	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.10379
layer V of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.936356
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
hsa-miR-548m	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
A549_Iniparib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141172
BRD-K20714346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36895
496100383_HIP_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.61092
TAB1	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224503
P53-22387025-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MARK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04578
CASKI	DepMap CRISPR Gene Dependency	1.0	3.78004
DLD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63467
lens	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-561	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
CDC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.66043
A549_Selisistat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0239906
Anterior olfactory nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14175
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.83772
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040059
PMC10591418-12711_2023_849_MOESM11_ESM.xls-AA_E18_vs_LS_E18-gene_name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146982_4_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A50287893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37013
CDC42EP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30567
BRD-K61022988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11462
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.51838
OlfactoryBulb	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.974397
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.14511
HT55	Achilles Cell Line Gene Essentiality Profiles	1.0	1.13302
BRD-K48143921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20062
alpha-amino acid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.4016
CIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75025
ZNF324B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38162
GSE207471_2_v_3_btla_human	RummaGEO Gene Perturbation Signatures	1.0	null
OLIG2-29049317-MOUSE-SPINALCORD	ChEA Transcription Factor Targets 2022	1.0	null
CHLA57	DepMap CRISPR Gene Dependency	1.0	4.15283
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5344
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.26259
GSE121319_1_v_0_gprc5a_human	RummaGEO Gene Perturbation Signatures	1.0	null
DKMG	Achilles Cell Line Gene Essentiality Profiles	1.0	1.55623
NFE2-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
UBXN2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54147
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6685
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
bone marrow	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223177
glutamate-ammonia ligase activity	GO Molecular Function Annotations 2023	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7161-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
m1 melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.686776
XRCC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31217
Hnf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.7614
melanocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06806
SNU423	CCLE Cell Line Gene CNV Profiles	1.0	1.3468
PANC0203	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3735
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6266
VAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5524
Agranular insular area, ventral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5699-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211356
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2219
Acute Myeloid Leukemia_LAML_TCGA-AB-3000-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0539
JM1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K26314798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.159
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0992
BRD-K59821747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20661
Eye degenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
Ciliary epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.604
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A0C8-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-6737-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Secondary motor area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01315
anterior pretectal nucleus, dorsal core part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17401
CRCGN013_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47245
PHYHIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67354
Anterior hypothalamic nucleus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20696
OE33	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.5832
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040405
OVMIU	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BHLHA15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67896
BRD-K97682096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27554
Neoplasms	CTD Gene-Disease Associations	1.0	1.02225
ammonia ligase activity	GO Molecular Function Annotations 2015	1.0	null
FARAGE	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_17446_KD_NOX4_SRP290143	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.01557
external part of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86975
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23707
A549_PFI-1_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157295
Brain Lower Grade Glioma_LGG_TCGA-DH-5140-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLEKHN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.36139
NCIH1437	CCLE Cell Line Gene Expression Profiles	1.0	2.79316
GPBP1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74624
A549_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016335
ZNF493	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28678
TARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06046
P2RX7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0042172
Nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
NOP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03072
NCI H23	BioGPS Cell Line Gene Expression Profiles	1.0	1.16628
CISD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98864
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
8MGBA	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73016
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12284
GSE246195,GSE246305_4_v_3_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1434
Obesity-related traits	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.530103
CHAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45976
TRAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12982
EW22	DepMap CRISPR Gene Dependency	1.0	3.96036
UBE2D3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00531623
CRCGN016_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.80714
amyotrophic lateral sclerosis	GWASdb SNP-Phenotype Associations	1.0	0.510092
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054508
TNKS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53593
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16038
ventral part of CoP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1721
temporotympanic muscle trigeminal motor cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11291
L-Glutamic Acid	DrugBank Drug Targets	1.0	null
HMGN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70559
POU2F2	JASPAR Predicted Transcription Factor Targets	1.0	null
Alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Primary somatosensory area, upper limb, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11291
primary auditory cortex (core)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.967172
medial part of r2B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01315
JHH1	CCLE Cell Line Gene Expression Profiles	1.0	2.04933
RNASE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37727
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
LEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28443
SFT2D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06281
STOML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92138
BRD-K94409042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23238
Perturb_7783_KD_BS691_SRP030639	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
PPIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27398
Peters anomaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
PNPLA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14675
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6024-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Glutamine synthetase/guanido kinase, catalytic domain	InterPro Predicted Protein Domain Annotations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7910-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MARCKSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21782
A549_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142191
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.8487
NCIH1563	CCLE Cell Line Gene Expression Profiles	1.0	1.39176
H3118	DepMap CRISPR Gene Dependency	1.0	3.0734
ITPRID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15805
NHEJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5328
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58137
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PATU8902	DepMap CRISPR Gene Dependency	1.0	2.68584
mantle zone of r3BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11291
FAM76B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57997
BRD-K11089039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22683
NCIN87	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.36058
H2AC19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47255
TFDP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59695
NCI-H2126	GDSC Cell Line Gene Expression Profiles	1.0	2.38242
BICDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71548
retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.185016
BRD-K93697231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3069
BRD-K75094875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07786
mantle zone of CoPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1719
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A57E-11A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOS::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8414
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.2314
Intrinsic component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.205
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
paraventricular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26249
TMEM179B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0433
TAB3	Pathway Commons Protein-Protein Interactions	1.0	null
basolateral amygdaloid nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17401
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1972
A549_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162945
Eye accommodation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.307
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6345
BRD-K13927197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87566
BRD-K55648964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17899
HEYA8	Achilles Cell Line Gene Essentiality Profiles	1.0	1.8126
Glutamine glutamate conversion	PANTHER Pathways	1.0	null
breast	HPA Tissue Protein Expression Profiles	-1.0	-0.826216
epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060734
C6orf62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61602
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5589-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K54198678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47124
KNS-81-FD	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN008_HEPG2_24H:E12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06745
DMS454	CCLE Cell Line Gene Expression Profiles	1.0	1.43976
PFKFB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61427
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
MAGED4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29309
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3923
ILF2	Pathway Commons Protein-Protein Interactions	1.0	null
FZR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22105
BRD-K47951404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57246
BRD-K47508820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73939
BRD-K39863565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19882
within	GeneRIF Biological Term Annotations	1.0	null
Bile duct carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
BRD-K52139780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07606
Mucopolysaccharidosis	DisGeNET Gene-Disease Associations	1.0	null
BRD-A21877498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0207
LZTS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18488
BRD-K65392908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55563
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN008_HEPG2_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11345
PSORS1C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99858
NTAQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54537
HOXA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59491
HT144	DepMap CRISPR Gene Dependency	1.0	2.37448
Prostate adenocarcinoma_PRAD_TCGA-EJ-5542-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
GSE147366_3_v_0_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9148
SOX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5078
BRD-K95479169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72338
chromosomal part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046395
acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067342
RNASE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33372
IKZF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22616
Epstein-Barr virus copy number in lymphoblastoid cell lines	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.639794
subbrachial nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14929
SNU324	CCLE Cell Line Gene CNV Profiles	-1.0	-1.79772
NCI-H2135	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.61315
FOXR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40446
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59981
ZNF578	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88834
ZNF24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.73
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.898598
Lung squamous cell carcinoma_LUSC_TCGA-39-5034-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
glutamine metabolic process	GO Biological Process Annotations 2015	1.0	null
HT29	BioGPS Cell Line Gene Expression Profiles	1.0	0.835155
Lung adenocarcinoma_LUAD_TCGA-49-6743-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5166
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
hsa-miR-377	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GARIN1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0548
BRD-K65314728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43808
r2 part of the trigeminal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01315
GSE228181_3_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.925784
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.717
medial part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.947
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2746
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24028
SF3B3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64251
JHESOAD1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.32082
superficial stratum of Ist	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22855
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.836055
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.059954
superficial stratum of RtC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59878
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HIC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13165
CHST6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53428
p1B part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00181
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A410-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5879-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF211	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4169
SNG-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0407
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.844884
C4orf36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65416
intergeniculate leaflet	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
mantle zone of AStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
r10 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.95482
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
P300-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
FOSL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0262
intermediate stratum of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6121
OCT4-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MRPS35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90975
MYRFL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3077
SSB	Pathway Commons Protein-Protein Interactions	1.0	null
CTSL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23393
EXOSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86096
A549_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229799
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
SEC23A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39361
ASB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80041
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.47564
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.5536
ITSN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53646
BRCA1_DEPLETION_GDS3791_38_human_Hela	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
hsa-miR-4461	TargetScan Predicted Conserved microRNA Targets	1.0	0.072324
NCIH522	CCLE Cell Line Gene Expression Profiles	1.0	1.73446
BRD-K48880196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16637
Lung squamous cell carcinoma_LUSC_TCGA-90-A59Q-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PTOV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82067
HOXA10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70854
RBM46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53357
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EJ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39390441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79571
GSE116242_0_v_1_olig2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-448	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
ZNF781	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87941
Anterior olfactory nucleus, external part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47898
Multilymphoid progenitor cell_Umbilical cord blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
NKX6-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4286
PMC6813882-NIHMS1526297-supplement-2.pdf-18-KLF6_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
skin	HPA Tissue Gene Expression Profiles	-1.0	-0.969592
Acute Myeloid Leukemia_LAML_TCGA-AB-2808-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.78401
BRD-K07755570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0591
DDX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52068
BRD-K33221810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23073
hsa-miR-3156-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GATA3-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-1253	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BRD-K71592817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02778
JEKO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57081
hsa-miR-4490	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GOS3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4894
anterior olfactory area, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28672
septostriatal part of the olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17401
NCAPD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13215
A549_NVP-BSK805 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0263469
BRD-K42987166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1167
hsa-miR-498	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
GSE154350_1_v_0_ascl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleus of the inferior collicular brachium, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44526
HCC366	CCLE Cell Line Gene CNV Profiles	1.0	1.59581
SH3GL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0975
intermediate stratum of PcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17401
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE146982_4_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K13038935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35119
SELENBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2134
Anteroventral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26193
NCIH1395	CCLE Cell Line Gene Expression Profiles	1.0	2.40872
A549_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176987
SLC35A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08087
SW1783	Achilles Cell Line Gene Essentiality Profiles	1.0	1.12612
PMC6934839-41598_2019_56277_MOESM2_ESM.xlsx-ONECUT2_DOWN-Gene_Symbol_ONECUT2	Rummagene Transcription Factor Associations 2026	1.0	null
Inferior salivatory nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05875
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
RAB21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53997
BRAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25229
LRFN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24042
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.25989
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5985-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LPAR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17642
lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.569552
EFE184	DepMap CRISPR Gene Dependency	1.0	2.78445
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A82B-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5691-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.5507
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
SLC49A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20887
Metabolite levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.504576
Adrenocortical carcinoma_ACC_TCGA-OR-A5LL-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Aminoglutethimide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201141
BRD-K43284834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58479
VDR-24787735-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CISD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93094
Infralimbic area, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69524
CAPN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53962
ZXDC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3455
A549_AZD1480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193384
BRD-K31093279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76007
BRD-K74486924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11589
BRD-K64451677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41278
BRD-K39227064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31386
PGM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00267
BRD-K19527338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74091
ODF2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15979
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.3792
mantle zone of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43727
NCIH2110	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48869
retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.444884
AdrenalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.833407
RBMXL2	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN014_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.36783
ABCA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95994
RMUGS	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33397
BRD-K97247086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24555
superficial stratum of r2Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
BRD-A20305532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12632
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.8951
RARA_KD_GDS4065_42_human_MCF-7	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
primary motor cortex (area M1, area 4)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.947099
PAX5_OE_GDS4978_548_human_L428-PAX5	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
DUT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52515
GTF3C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45707
Precommissural nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05875
RELCH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2816
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A556-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF559	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51874
A549_SRT3025 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143248
LRRC41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47236
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4340-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSC4	DepMap CRISPR Gene Dependency	1.0	6.72777
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.53103
rhombomere 11	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45629
G141	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9015
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.081
MZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39409
NFYA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K58113140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28947
SMRT-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CCDC88A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12735
CRCGN014_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.2908
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02423
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.4679
MAFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4742
SOX6-21985497-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
LS-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
JHH5	CCLE Cell Line Gene Expression Profiles	1.0	1.53294
ZNF217_OE_GDS4885_317_human_MDA-MB-231 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
AOB, mitral cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46958
CCDC136	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53744
disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.158605
BRD-K05222558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55373
BRD-K82082713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31777
H3K9me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.027451
lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.470375
GSE154936_3_v_4_remdesivir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UBE4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6429
Fibula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.746
SPG21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05892
SEC31B	Pathway Commons Protein-Protein Interactions	1.0	null
ORC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67655
Central amygdalar nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59878
hsa-miR-606	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
CRCGN014_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.97665
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.46686
Gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
TE4	CCLE Cell Line Gene Expression Profiles	1.0	1.74835
BRD-K41307047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77583
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
BRD-K67561376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68617
dorsolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13108
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3326
BRD-K50700697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90603
ZKSCAN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3057
A549_M344_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131283
A375	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K78681155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89787
GSE197342_2_v_0_berberine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Hindbrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Lung adenocarcinoma_LUAD_TCGA-69-7764-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TIGD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38448
uterus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.881805
RUNX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7004
A549_Daphnetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161871
BRD-K30530468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72688
medial mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
NCIH1869	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47126
PMC9894241-pnas.2211429119.sd05.xlsx-G3_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.11908
SHQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62367
BRD-K73296174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0404
BRD-K55642725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53096
MFAP3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82568
BRD-K06157545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18054
FARS2	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3WX-01A-22R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDK8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56723
Cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HUWE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00667593
bronchus	HPA Tissue Protein Expression Profiles	1.0	0.877031
mantle zone of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.94722
Metencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ZNF772	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67023
TIGAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94669
HEY	DepMap CRISPR Gene Dependency	1.0	4.49609
GPHA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01482
Acute Myeloid Leukemia_LAML_TCGA-AB-2880-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27003
A549_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161817
PTPN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39246
H4C6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.70545
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7561
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
TRAF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31666
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.76868
PMC3419980-leu201249x4.xls-H3K9Ac-RUNX1ETO_peaks_2fold-All_gene_regions_overlapping_with_RUNX1-ETO_peaks_changing_histone_acetylation_more_than_2-fold_after_knock-down_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
organonitrogen compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
A549_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165942
Lissencephaly 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.387
Nephridium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.702
RCCFG2	DepMap CRISPR Gene Dependency	1.0	2.68198
BRD-K03265347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06385
hsa-miR-4317	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
atrophy/degeneration affecting the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.510092
nasopharynx	HPA Tissue Protein Expression Profiles	1.0	0.877031
CRCGN014_HEPG2_3H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4729
CRCGN013_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9641
HS 940.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.9028
ERAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14922
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
mammarygland.lact.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.18477
IFT46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96252
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5973-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7044-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29825
BRD-K38358574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57048
A549_PCI-34051_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203053
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00108
hsa-miR-640	TargetScan Predicted Conserved microRNA Targets	1.0	0.075559
KYSE-140	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28283
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I7-06A-22R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CLDND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.9804
A549_ZM 447439_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251438
CRCGN014_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.98317
CA9-22	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.974643
CRCGN017_MCF10A.WT.HP_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09695
GSE217363_4_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3211
FAM216A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48992
reported	GeneRIF Biological Term Annotations	1.0	null
USP10	Pathway Commons Protein-Protein Interactions	1.0	null
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
A549_Azacitidine_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190914
SSNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30999
GSE217378_1_v_0_lin28b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K46095779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19771
KNS-62	GDSC Cell Line Gene Expression Profiles	-1.0	-2.00394
GSE227592_10_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Inner acrosomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.662
PHC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51546
MIR122_OE_GDS3470_573_human_Embryonic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CL11	CCLE Cell Line Gene CNV Profiles	-1.0	-2.07292
NCIH1385	CCLE Cell Line Gene Expression Profiles	1.0	1.37273
GSE228181_0_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF691	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42096
PCGF2-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PRPS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00503077
Eye	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
JUND	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Anterior olfactory nucleus, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08221
splicing	GeneRIF Biological Term Annotations	1.0	null
BRD-K21546432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16241
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5690-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stratum lacunosum-moleculare of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.833265
HOMEZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11931
CELSR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90182
EPHA4_knockout_227_GSE34430	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.52858
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.9405
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.48282
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JA-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1423
PARN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72239
TTC9C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25972
Perturb_7809_KD_IBTK_SRP079879	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.63851
CRCGN017_MCF10A.WT.HP_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1528
SPDEF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00510422
ACTR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78469
hsa-miR-4679	TargetScan Predicted Conserved microRNA Targets	1.0	0.123298
acute lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069674
DMS-53	GDSC Cell Line Gene Expression Profiles	1.0	1.62353
BMAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29187
BRD-K47858507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25923
CDC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15163
NCIH1435	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3259
ZNF175	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30722
RNF31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09561
HEPG2	DepMap CRISPR Gene Dependency	1.0	2.96258
GSE217526_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TMEM219	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68442
CRCGN011_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.628
PMC3923219-mmc2.xls-Table_S1-Table_S1_Differential_Gene_Expression_in_GFP-PRDM1_transduced_H9_hESCs_PRDM1	Rummagene Transcription Factor Associations 2026	1.0	null
KPTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47831
SMURF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5091
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WM-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Costunolide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155054
ligase activity, forming carbon-nitrogen bonds	GO Molecular Function Annotations 2015	1.0	null
CREBL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5563
BRD-K25097691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12708
ZNF749	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50837
layer 3 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05875
GSE202434,GSE202438_9_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
STS-0421	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.878645
TPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93362
FUCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06291
BRD-K95417411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10668
GATAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97155
Lung squamous cell carcinoma_LUSC_TCGA-56-7223-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CORL51	CCLE Cell Line Gene Expression Profiles	1.0	1.40446
SH4	CCLE Cell Line Gene CNV Profiles	-1.0	-2.31154
Iris dilator muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.0
TTLL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82395
hsa-miR-1291	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
BRD-K75620843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00504
ATP8B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47289
smallintestine	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.865493
FAM229B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75984
PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K37515001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08023
BRD-K88385836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87909
Lymphnode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.964424
lateral part of r5B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13644
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13023
ZNF582	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8362
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21509
EMX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87629
PMC9883165-41375_2022_1744_MOESM3_ESM.xlsx-RNA-Seq_of_CEBPA_specific_genes-Unnamed_1_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF98	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7973
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.1418
PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K90956468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04008
FBXO41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06516
EPB41L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99914
C22orf39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.791
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TLR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18674
single-organism biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE215086_4_v_7_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KIF20A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55483
BRD-K53335788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84773
H3K27me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MED20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99742
MORCPR	CCLE Cell Line Gene Expression Profiles	1.0	1.56656
BRD-K48676303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21295
Lung squamous cell carcinoma_LUSC_TCGA-90-A4ED-01A-31R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Roxadustat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.020256
Retrosplenial area, lateral agranular part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0743
lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.758193
CCNQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81645
bone marrow cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.695354
TBC1D23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12959
RAF1_activemutant_219_GSE42964	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.43054
CCM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16061
pallidal amygdala	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59878
kidney_b	HPA Tissue Sample Gene Expression Profiles	1.0	1.30412
EW7	DepMap CRISPR Gene Dependency	1.0	4.65242
PPP1R15B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27488
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7435-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Vermiform appendix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Uterus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00895
BRD-K73581966	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1313
ZDHHC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.62019
RELA_01_30	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.29546
BRD-K97526959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31008
A549_ENMD-2076_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183897
AP1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62321
metaraminol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02783
KRT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87305
BRD-K23430426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2255
MZ in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.936356
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.925784
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.71686
NDUFB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97147
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040804
GSE218060_7_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
r9 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.62379
NFATC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03076
LSR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39569
Sclerocornea	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.518
carboxylic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
ISTMES2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43889
Skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9148
chr6_63438760_T_G_b38	GTEx eQTL 2025	1.0	1.06857
outer CP in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.931231
LSM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15465
synovial tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.109955
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.892375
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q5-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOXC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3219
ventrolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.878125
Langer-Giedion Syndrome	DisGeNET Gene-Disease Associations	1.0	null
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.944094
Perturb_15737_KO_Camk2d_SRP281889	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.79839
GSE197564,GSE198513_2_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-V1-A8WV-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CBX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23854
CHD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12452
NCI-H1395	GDSC Cell Line Gene Expression Profiles	1.0	2.40078
HL60	Achilles Cell Line Gene Essentiality Profiles	1.0	2.51077
Paraventricular hypothalamic nucleus, magnocellular division, medial magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04346
OVMANA	CCLE Cell Line Gene Expression Profiles	1.0	1.67743
IQSEC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97522
Esophageal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.678
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34001
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.2771
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A184-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13574
SH3BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50494
NCKAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98288
DDX56	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33027
PMC12211054-spectrum.00100-25-s0002.pdf-56-IRF7_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
DPRX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1886
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81I-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6545035-12943_2019_1031_MOESM7_ESM.xlsx-Sheet1-Supplementary_table_5_The_significant_reduced_genes_in_TET1_knockdown_cells_TET1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K63169405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14549
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.934144
layer 4 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11291
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
SREBF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15328
GSK3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48169
SH3GLB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69872
septopallidal part of the olfactory tuberculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
Lung adenocarcinoma_LUAD_TCGA-62-A46S-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100515_HIP_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.23973
LSM3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Orthogonal array	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.779
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29949
BRD-K69699301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15442
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A5Y1-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TP73	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.22411
ABHD17A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4919
RPIA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93882
ANKFY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38487
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05698
EBC1	DepMap CRISPR Gene Dependency	1.0	4.30972
hsa-miR-3200-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.031759
GJA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32838
Muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K72892670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28332
BRD-K41324679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07991
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7397-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF141	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00482346
glutamate-ammonia ligase activity	GO Molecular Function Annotations 2015	1.0	null
PRKRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05298
SART3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14623
mast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.331194
HCC1569	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PPM1J	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74689
BRD-K78873216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52335
LRRC59	Pathway Commons Protein-Protein Interactions	1.0	null
lung	GeneRIF Biological Term Annotations	1.0	null
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6792
BID	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18601
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.973517
C1orf216	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20181
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71W-01A-12R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PECAPJ41CLONED2	DepMap CRISPR Gene Dependency	1.0	3.85587
GSE210476_11_v_10_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMAD1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TRIM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26298
PTBP1_02_144	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.45943
APOB	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K55562948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10301
A549_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157519
BRD-K59484021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47766
SEPHS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00664099
Acute Myeloid Leukemia_LAML_TCGA-AB-2955-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stratum radiatum of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.987224
ZNF354B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55048
IRS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95357
Biliary tract cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
Lung adenocarcinoma_LUAD_TCGA-97-7938-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BTN3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7059
DDX25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74553
ventral linear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09898
Lung adenocarcinoma_LUAD_TCGA-L9-A444-01A-21R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K67011787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27305
GJD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94398
NDUFA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03598
MESP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01087
non-gestational choriocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
ADD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18706
NCI-H1573	GDSC Cell Line Gene Expression Profiles	1.0	1.45229
NCO2	CCLE Cell Line Gene CNV Profiles	1.0	1.50964
TNFSF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58907
FOSL1::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.09
BRD-K36493118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24068
BRD-K98578493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20019
BRD-K14476597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01694
ATG9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60037
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03446
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.910541
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3609
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.46603
Lens cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.902
BRD-K75724196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22341
BRD-K35717699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48857
hsa-miR-2053	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NDUFS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02545
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1081
lateral tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18991
PMC9894241-pnas.2211429119.sd05.xlsx-G4_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
Presubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38612
internal globus pallidus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05875
SLPI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00495637
Paw	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.541
Frontal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.167
motor neuron atrophy	GWASdb SNP-Phenotype Associations	1.0	0.510092
NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3937
SLR20	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73317
HMGCS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81585
BRD-K51707293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.925
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2R8-01A-21R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLAMF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00497422
ZNF471	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49761
hsa-miR-3161	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
DMRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83248
BT483	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7728
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6603
EM2	CCLE Cell Line Gene CNV Profiles	1.0	1.85055
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3131
ZC3H12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26965
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IK-01A-32R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_02_185	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.80735
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1972
Colon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
chr6_63437739_A_T_b38	GTEx eQTL 2025	1.0	2.77842
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.927078
U87MG	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54344
A549_SRT2104_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157247
PMC11058205-42003_2024_6202_MOESM6_ESM.xlsx-Data3a_DirectGene_CEBPA-Data3a_Genes_directly_regulated_by_CEBPA_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
r9 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59085
HOXD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61483
BRD-K78438852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08283
PSMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10003
lens nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.03083
BRD-K31870622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68694
GCNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01919
organic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K96431636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41812
GNE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67782
SCPEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32212
BRD-K28691459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08189
osteoblasts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.14189
heart muscle	HPA Tissue Protein Expression Profiles	1.0	0.877031
Acute Myeloid Leukemia_LAML_TCGA-AB-2862-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.983206
Depressive Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
lateral part of alar p3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26193
NCCLMS1C1	DepMap CRISPR Gene Dependency	1.0	4.11238
RMUGS	Achilles Cell Line Gene Essentiality Profiles	1.0	1.04073
CRCGN015_MCF10A.TP53.M_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.466
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.997
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5988-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
periventricular stratum of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
embryonic fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.159712
TE15	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.0683
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.94055
TLX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3739
GSE146982_7_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170008
Lef1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.9473
primary auditory cortex (core)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.223
A549_SRT2104_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110913
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.874894
ARFIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47421
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052679
heart	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.911073
superficial stratum of p3ZL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0743
Postlarva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.599
NCIH2342	CCLE Cell Line Gene Expression Profiles	1.0	1.50183
CALD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51855
ERG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23452
TCF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19773
HOXA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2656
sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K71141540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09847
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.24899
BRD-K79937734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57843
hsa-miR-1910	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE119978,GSE180930_6_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172073
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.46584
PLK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1215
sublayer 6b of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17401
GSN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19873
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07122
shoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.290652
BRD-K63645840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04502
ATF3	ChEA Transcription Factor Targets	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.33641
GSE119978,GSE180930_6_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF197	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22453
MYNN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14695
RNF139	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55035
Perturb_8357_KO_DAPK1_SRP356770	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.95197
MNX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5388
SLC4A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47843
RASD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65596
sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046527
BRD-K78813464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41608
KIF3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00503689
BRD-K19502817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12803
Bile duct cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
ACCMESO1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53343
UBA52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03659
NSMAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.51989
ENY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65098
GSE180951_6_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.876832
ERF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42486
DNAJC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90933
TPCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.185
GMPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01986
hsa-miR-499a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
BRD-K81266242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63797
CRCGN010_HEPG2_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44903
CDX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37921
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4642-01B-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00565773
cellular process	GO Biological Process Annotations 2015	1.0	null
A549_SRT3025 HCl_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163177
Lung adenocarcinoma_LUAD_TCGA-NJ-A55O-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K83569804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06343
PARP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41659
subbrachial nucleus, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45668
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
INA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.412
GSE146982_3_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.2824
inner CP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28843
Sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_ZM 447439_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163099
hsa-miR-4666-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Stat6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.4989
HCaRG_OE_GDS2426_711_human_HEK293 kidney cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
mucopolysaccharidosis iv	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.31624
NCIH2030	CCLE Cell Line Gene Expression Profiles	1.0	1.77943
SOX10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4414
NCIH292	CCLE Cell Line Gene Expression Profiles	-1.0	-1.5171
Anterior olfactory nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51384
PARPBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.46968
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.3807
tonsil	HPA Tissue Protein Expression Profiles	-1.0	-0.826216
Senile cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.49
BRD-K33462260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94293
SEC24D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74631
MYO1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53244
FANCI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67412
thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047954
FSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95018
NSDHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02573
GSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2891
A673	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80085
KHSRP	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65126
medial part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.30686
molecular_function	GO Molecular Function Annotations 2015	1.0	null
BRD-K42253676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09703
BRD-K33805386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01476
GSE197555_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DGCR8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56365
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.30604
PMC12172627-NIHMS2085635-supplement-5.xlsx-E2F1_GENIE_Results-Unnamed_1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
eldeline-3750	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TE4	CCLE Cell Line Gene CNV Profiles	1.0	1.49958
SU-DHL-8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-34b	TargetScan Predicted Conserved microRNA Targets	1.0	0.15008
DMS-79	COSMIC Cell Line Gene Mutation Profiles	1.0	null
layer 2 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
BRD-K46162352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53557
Lung adenocarcinoma_LUAD_TCGA-86-8073-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00867
WDR77	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8158
496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.68444
BRD-K59606563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32639
BRD-K32146668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00396
Bladder Urothelial Carcinoma_BLCA_TCGA-H4-A2HQ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIRT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30091
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5613
FLI1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4833-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150655
SCML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50818
Lung squamous cell carcinoma_LUSC_TCGA-56-7582-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JDP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4114
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A6HO-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Hesperadin_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0107179
CRCGN009_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.62238
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29802
PTCD3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K05796780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04064
SH2B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53592
BRD-A42579861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50927
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.1068
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.062
dorsomedial preoptic area, superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0743
endogenous depression	GWASdb SNP-Disease Associations	1.0	0.674534
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_4day-MOI-10^3_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.24595
NCIH1650	Achilles Cell Line Gene Essentiality Profiles	1.0	1.41972
suprachiasmatic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59878
NCIH2023	CCLE Cell Line Gene Expression Profiles	1.0	2.20724
DBF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52203
hsa-miR-23a	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
GSE197342_1_v_0_berberine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TBRG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39193
superficial stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10995
RUNX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56027
BRD-K59445060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14599
OVCAR-8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
18801183-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.66311
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.45405
LS	DepMap CRISPR Gene Dependency	1.0	2.50978
BRD-K77082178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15398
Vitreous humor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.929
small intestine	HPA Tissue Protein Expression Profiles	1.0	0.877031
LIM1215	COSMIC Cell Line Gene Mutation Profiles	1.0	null
rostral periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44642
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22611
Female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BCS1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97164
VENTX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8091
ACSL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56704
ATXN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30338
mantle zone of r2BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01315
periventricular stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05321
BRD-K26680822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60664
ZNF365	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67613
ZNF774	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71403
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3358-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3160-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
BRD-K45091989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09753
CKS1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45137
reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26193
SRP14	Pathway Commons Protein-Protein Interactions	1.0	null
P53_DN.V2	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
A549_Ellagic acid_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191357
Prostate adenocarcinoma_PRAD_TCGA-J4-A6M7-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0915
A549_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0106598
SAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08863
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P7-A5NX-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVKATE	CCLE Cell Line Gene CNV Profiles	-1.0	-1.82569
PNKP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47234
GDAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38578
BRD-K53110645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50504
A549_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015178
BRD-K97138361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24867
USP33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97911
hsa-miR-4760-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
ESYT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56454
ZBTB32	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.008
DPRX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58998
ARX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16597
BRD-K04192407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10286
NR1D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78131
CRCGN017_MCF10A.TP53.M_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47093
TCFCP2L1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
GTF2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04013
PABIR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84484
Retinitis Pigmentosa	DisGeNET Gene-Disease Associations	1.0	null
BRD-K67980271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.023
Lateral terminal nucleus of the accessory optic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01315
hsa-miR-23b	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
A549_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208992
HEATR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77979
Oligospermia	CTD Gene-Disease Associations	1.0	1.15089
COLO-800	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Superior olivary complex, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40064
BRD-K36465335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6463
Appendix	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.961907
RMGI	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46134
CRCGN015_MCF10A.WT.HP_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39357
A549_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155679
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.578
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA2_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4422-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
synthetases	GeneRIF Biological Term Annotations	1.0	null
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.878125
CRCGN010_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.34795
organonitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
chaperonelike	GeneRIF Biological Term Annotations	1.0	null
PMC12088458-pnas.2419691122.sd01.xlsx-CAGE_genes-Non-stringent_differentially_expressed_genes_from_CAGE_sequencing_upon_TBX3_overexpression_in_HCT116_TBX3	Rummagene Transcription Factor Associations 2026	1.0	null
C19orf53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50049
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
pimethixene-2395	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.3416
A375	CCLE Cell Line Gene Expression Profiles	-1.0	-2.57225
ALDH1A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00410314
Skin Cutaneous Melanoma_SKCM_TCGA-GF-A769-01A-32R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF227	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20543
huh-7	BioGPS Cell Line Gene Expression Profiles	1.0	1.89634
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57525
Presbyopia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.417
ESRRB-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
micropexophagy-specific membrane apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.841
r7 part of the dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05363
Medial septal complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0336
KLF4-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
A549_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210886
MEX3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.67289
ALAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.01487
glutamine family amino acid metabolic process	GO Biological Process Annotations 2015	1.0	null
CDK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58298
CRCGN009_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10702
KMT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96041
PSPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12143
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A4BA-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-HR-A5NC-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01082
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13174
r9 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.4976
DNAJA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1059
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.08596
A549_2-Methoxyestradiol_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0322812
COR-L32	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.424
BAIAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18498
CEP43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43455
ZNF487	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65937
OGFOD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00469005
Bed nuclei of the stria terminalis, posterior division, interfascicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14442
Retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
TK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.975676
Lung squamous cell carcinoma_LUSC_TCGA-66-2756-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GYG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83873
PODXL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94225
CSRP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32036
1,4-chrysenequinone-7139	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE217378_2_v_0_lin28b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116819
HEBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31482
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02586
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24015
GSE121866_1_v_3_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ATG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05753
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.968949
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041013
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.25748
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.77725
GSE125219,GSE125221_3_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
HACD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56466
ZNF599	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32736
RPS25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3174
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
GSE102870_3_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
viral genome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.39471
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RT-A6Y9-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
EZH2-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.25989
PCI-4B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
intermediate stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.10439
CRX-20693478-RETINA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
P31-FUJ	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K98968761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32913
DDX21	Pathway Commons Protein-Protein Interactions	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
GRHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4603
outer CP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51858
Gastrodermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.102
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.1035
LOX-IMVI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.844884
BRD-A21814529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18031
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4864-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
glutamine biosynthetic process	GO Biological Process Annotations 2015	1.0	null
HDDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84623
UBE2K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49035
COLO792	CCLE Cell Line Gene CNV Profiles	-1.0	-1.52388
A549_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206394
BRD-K86008496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14394
ZFYVE16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34811
TPRKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83407
liver_d	HPA Tissue Sample Gene Expression Profiles	1.0	0.97626
ITGA11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0045029
PRDX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43686
EXOC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68681
LARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28371
CASC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92679
hsa-miR-4275	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Superior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43802
BRD-K77643021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08473
DNAAF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.93347
TP53_01_31	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.00817
lateral superior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09163
PTPN1_KD_GSE54157_673_human_KM-H2	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
ZNF90	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65849
NCIH2286	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34119
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2625
BRCA1_DEPLETION_GDS3791_502_human_Hela cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K41306114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16954
HOXB5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7415
substance-related disorder	GWASdb SNP-Disease Associations	1.0	0.135652
DNMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20365
Brain Lower Grade Glioma_LGG_TCGA-HT-A74H-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TOV112D	CCLE Cell Line Gene Expression Profiles	-1.0	-1.72135
Lung squamous cell carcinoma_LUSC_TCGA-22-4594-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K92520489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.025
Agranular insular area, ventral part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.88065
CRX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6155
RGL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74888
EKVX	GDSC Cell Line Gene Expression Profiles	1.0	2.09328
NCIH522	CCLE Cell Line Gene CNV Profiles	1.0	2.88339
hsa-miR-4703-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
BRD-K00551139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13916
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Cataract 38	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.401
INSIG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95879
NCI-H1734	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32102
Skeletal muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ABCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61281
A549	BioGPS Cell Line Gene Expression Profiles	1.0	1.12884
glutamine family amino acid biosynthetic process	GO Biological Process Annotations 2023	1.0	null
CRCGN011_HEPG2_24H:A09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1396
NMYC-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K18409585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02935
GNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50999
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A06158172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0324
ATRX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56027
inner CP in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.82945
BRD-K06226868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06559
BRD-K97241181	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54423
Lung adenocarcinoma_LUAD_TCGA-97-A4M5-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12913833-12672_2026_4481_MOESM3_ESM.xlsx-Table_S1-Table_S1_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Glutamine synthetase, catalytic domain	InterPro Predicted Protein Domain Annotations	1.0	null
FOXE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39085
PLBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27447
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.389289
BRD-K63984483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55073
MRPL21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41545
BRD-A95442017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08248
EBC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K66700691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12671
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9775
GDAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66327
MZ7-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A42Z-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AURKC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49954
GSE188382_4_v_0_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RABGEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90801
GSE211262,GSE211263_0_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SLC25A1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE242290_3_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AICD_Induced  expression / Over-expression_GDS1979_288_human_SHEP-SF neuroblastoma	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ATPAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22595
LPS141	DepMap CRISPR Gene Dependency	1.0	2.3475
hsa-miR-1256	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.388535
predominantly	GeneRIF Biological Term Annotations	1.0	null
LEUTX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78984
abnormal motor neuron morphology	GWASdb SNP-Phenotype Associations	1.0	0.510092
Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6131-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44948
lymphoblastoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061939
GSE210662_3_v_0_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cerebellum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
NCIH1623	CCLE Cell Line Gene Expression Profiles	1.0	2.16511
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
PJA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20807
BRD-K79072801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34582
TMEM106C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00661
PMC10282096-41467_2023_39038_MOESM4_ESM.xlsx-All_genes_Upregulated-ENSG00000177426_TGIF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE207728,GSE207808_2_v_1_c646_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K53104784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07277
Posterior polar cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.363
ZNF354A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7459
BRD-K40985311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04759
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TOV-21G	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE121043_0_v_1_aldh1a1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_FLLL32_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130459
lateral septal nucleus, intermedio-intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63533
BRD-K66605600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71477
BRD-K99783492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15935
MESSA	CCLE Cell Line Gene CNV Profiles	-1.0	-1.99385
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K76738405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11203
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28212
TMEM81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52281
BRD-K52735829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68411
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.884602
SNTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99942
MMAC-SF	COSMIC Cell Line Gene Mutation Profiles	1.0	null
jurkat cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23604
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100573_HIP_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.27043
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.11908
PRSS50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89655
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5580-11A-02R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124721
SOX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6177
A-CA-04-2009(H1N1)_0Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.89088
centromedian nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59878
Posterior parietal association areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05875
lens fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.06691
496100502_TCx_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.42514
reticular complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26193
CDK5RAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88943
UMUC7	DepMap CRISPR Gene Dependency	1.0	2.64275
ATG2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0043
NEDD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42472
primary motor cortex (area M1, area 4)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13374
RP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1202
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01315
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4309
METTL27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.07377
BRD-K47314501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33718
DENND5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0771
BRD-K52500055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33985
GSE200982_0_v_2_plac8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Anteromedial nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0743
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
t-lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.08636
superficial stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.50491
PABPC1L2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15876
BRD-K13619800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19401
NOMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35034
PPP1R15A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33463
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.32344
SRSF7_02_02	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.39855
BRD-K34209560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19623
GSE125219,GSE125221_5_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cornelia De Lange Syndrome	DisGeNET Gene-Disease Associations	1.0	null
CCDC82	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20412
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.994425
BRD-K76518272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25044
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.972773
TNS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64029
superficial stratum of PO1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0743
interanterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26193
lens	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.934911
CRCGN015_HEPG2_48H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.51293
BRD-K44052748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10097
GSE146982_4_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K70588377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20433
FBXL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21048
SUPT7L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65541
A549_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144045
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6782
A549_Fasudil_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128007
NCI-H522	COSMIC Cell Line Gene CNV Profiles	1.0	2.76305
CFPAC1	CCLE Cell Line Gene CNV Profiles	1.0	2.13838
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular amino acid metabolic process	GO Biological Process Annotations 2015	1.0	null
lymphocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061231
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81G-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNF122	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01127
skeletal muscle	HPA Tissue Protein Expression Profiles	1.0	0.877031
BRD-K45714931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14501
ZNF589	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51569
Lens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.296
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PRKCSH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78487
A549_PFI-1_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178237
BRD-K37803976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04626
IFITM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27543
Juvenile Myoclonic Epilepsy	DisGeNET Gene-Disease Associations	1.0	null
KYO1	DepMap CRISPR Gene Dependency	1.0	2.06167
tear gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.635167
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.925784
SPG11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73123
BRD-K59626557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60249
TFAP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39085
PMC11058205-42003_2024_6202_MOESM6_ESM.xlsx-Data3b_DirectGene_FOXA1-Data3b_Genes_directly_regulated_by_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-7771-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PAPOLG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07098
SLR24	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.13728
BRD-K52688277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20909
OLIG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2681
A549_JNJ-7706621_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126963
BRD-K44298652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03553
DDAH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34827
PPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92715
ASH1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06474
hsa-miR-4789-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
SUMO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43279
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_Jurkat_LPS_vs_DC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
M059K	CCLE Cell Line Gene CNV Profiles	1.0	1.36374
HCC364	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55335
hsa-miR-505	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
A549_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129967
NR4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98694
glutamine metabolic process	GO Biological Process Annotations 2023	1.0	null
NCIH1650	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60755
BRD-K21176717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05261
nitrogen utilization	GO Biological Process Annotations 2023	1.0	null
SCH	COSMIC Cell Line Gene CNV Profiles	1.0	2.76305
LC1SQSF	CCLE Cell Line Gene CNV Profiles	1.0	2.50205
A549_Roxadustat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135834
CRCGN015_MCF10A.TP53.M_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4345
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Resveratrol_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139917
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.976043
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071985
erythroleukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.369747
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
HOXA7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	12.9209
A549_Aminoglutethimide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162931
SNU-C2B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GATD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04696
FGFR3_KD_GDS4454_79_human_RT112	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054885
Testis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K40001470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05475
CDV3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26003
CRCGN017_MCF10A.TP53.M_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52295
periventricular stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10229
Heart	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
VPS33B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03458
liver	HPA Tissue Gene Expression Profiles	1.0	1.23031
hsa-miR-4729	TargetScan Predicted Conserved microRNA Targets	1.0	0.115091
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE88819_7_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NIPA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76399
HDGF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02554
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27404
hsa-miR-412	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
AGS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_14475_KO_Trim28_SRP305340	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.30723
A549_SNS-314 Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202693
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7886-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SLC27A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84733
A549_JNJ-7706621_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131344
MAPK8IP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51938
EVX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94143
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040312
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
provirus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.425531
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0849
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.925784
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068389
mantle zone of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.30699
GATA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0991
ZBTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73171
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.33895
TGM2_KD_GSE23702_713_human_NB4 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PPP1R17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30605
TP63_01_196	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.88634
EIF4A1	Pathway Commons Protein-Protein Interactions	1.0	null
SOX21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27088
NH-12	GDSC Cell Line Gene Expression Profiles	-1.0	-1.44254
hsa-miR-3163	TargetScan Predicted Conserved microRNA Targets	1.0	0.03694
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.66243
BRD-K68072222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63337
chr6_63431296_A_G_b38	GTEx eQTL 2025	1.0	1.3684
H513	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MG-262-7068	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.48441
GSE168233_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE254526,GSE254528_0_v_1_phf19_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UACC257	CCLE Cell Line Gene CNV Profiles	1.0	1.68605
synoviocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.374993
BRD-K84800135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49285
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
HYAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23083
GAS2L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81719
CRCGN015_MCF10A_48H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00209
COTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49699
ZBTB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52782
GSE209928_0_v_1_kmt2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CSMD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00622292
NCIH1573	CCLE Cell Line Gene Expression Profiles	1.0	1.44378
mantle zone of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59878
glutamine family amino acid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
EZH2	ENCODE Transcription Factor Targets	1.0	null
BRD-K16312305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34452
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.543359
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.993398
TCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81403
Superior olivary complex, periolivary region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46996
SLF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2663
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228181_4_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Glaucoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
layer IIIb of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.929655
A549	GDSC Cell Line Gene Expression Profiles	1.0	1.60104
Adrenocortical carcinoma_ACC_TCGA-OR-A5KO-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRIM54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7385
IFIT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8973
A549_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146966
hsa-miR-1270	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
NO-10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
medial part of r3B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11291
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.388
BRD-K81952048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54089
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.289
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_3Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.41288
Lung adenocarcinoma_LUAD_TCGA-MP-A4T8-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE119978,GSE180930_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HELB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56073
lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.295492
Gynecophoral canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.105
Fundus of striatum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11616
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
NR6A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.15296
NCIH2126	CCLE Cell Line Gene Expression Profiles	1.0	2.86912
CL-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57585
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10735
496100359_PCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.75258
A549_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169272
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38099
BRD-K93998074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03937
ITPA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00643914
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GATA3_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBM47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.21769
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.940777
Uterine Carcinosarcoma_UCS_TCGA-N6-A4VD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bmmc cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.398735
PRKAG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00546053
C10orf82	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82599
Acute Myeloid Leukemia_LAML_TCGA-AB-3008-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29191
FEZF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91097
Perturb_8811_KD_CGAS_SRP340417	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Acute Myeloid Leukemia_LAML_TCGA-AB-2979-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1264	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
hsa-miR-4658	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
A549_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141493
SETDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28233
MFM-223	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K87929769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88118
NCIH2172	CCLE Cell Line Gene Expression Profiles	1.0	1.97733
Perturb_13876_OE_ABCC1_SRP301382	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
oxoacid metabolic process	GO Biological Process Annotations 2015	1.0	null
RRAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40371
SF126	GDSC Cell Line Gene Expression Profiles	-1.0	-1.83388
mantle zone of RtC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26193
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055161
GNG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02421
MCM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17309
intermediate stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
E2F1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CREBBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30069
hsa-miR-4291	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
MYOM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00538742
hsa-miR-1279	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Lens epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.895
BRD-K15343038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03124
melanoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071957
A549_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018688
Sclera	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.958
major	GeneRIF Biological Term Annotations	1.0	null
ES4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06684
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
Medial septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9034
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MCM3	Pathway Commons Protein-Protein Interactions	1.0	null
A549_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144452
Anterior olfactory nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59265
GSTZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22583
superficial stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17401
BRD-K76600600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05134
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.839964
Cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.547
BRD-K40117723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4229
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J3-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-5654-11A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13402127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39346
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.24732
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070674
GSE246195,GSE246305_2_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26366
PMC10256799-41598_2023_36660_MOESM3_ESM.pdf-1-DLX6_DLX6	Rummagene Transcription Factor Associations 2026	1.0	null
MIA-PACA-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22279
DENND4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95117
L-Glutamic acid	HMDB Metabolites of Enzymes	1.0	null
LRIG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99235
BRD-K31372389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51564
hsa-miR-4715-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
A549_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145281
polymorphic layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4324
placenta_6b	HPA Tissue Sample Gene Expression Profiles	1.0	0.994706
Mucopolysaccharidosis IVA	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.25
r10 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19229
Blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.219
BRD-K07384081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3588
lateral part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29536
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
NKX6-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.6053
NOTO	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2501
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.918968
A549_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140188
substance dependence	GWASdb SNP-Disease Associations	1.0	0.225966
BLVRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23234
TPM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62728
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.639619
RTKN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02338
PMC11960529-mmc4.xlsx-Ventricular_ZNF711_KOoverCT-gene_ZNF711	Rummagene Transcription Factor Associations 2026	1.0	null
A549_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168326
HOXD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.12742
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.1662
Lung adenocarcinoma_LUAD_TCGA-44-A47B-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
APELA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35762
BRD-K14269958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25899
RAB33B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.11228
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EL-01A-12R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.92112
BRD-K09991945_GSK-3-inhibitor-II_HA1E_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MEF2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4738
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051023
Internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ZMYM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51593
PES1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30078
abnormality of nervous system morphology	GWASdb SNP-Phenotype Associations	1.0	0.067369
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26193
BRD-K21969044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12375
STRN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87622
LIN54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47384
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.42587
ZNF490	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.34378
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.02062
FAAP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4165
inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.489691
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.3524
A549_SB431542_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162874
cerebralcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.2273
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.966974
HES7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51707
Mafb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.2626
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.074108
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5983
BRD-K43381631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44274
MDA-MB-231	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Ppara	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.6007
Rectum adenocarcinoma_READ_TCGA-DC-6157-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PTPN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00585997
hsa-miR-3646	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
A549_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149416
C17orf107	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27304
ACO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34208
A549_BMS-911543_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0114462
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Danusertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0244535
H3K27me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Vitreous chamber of the eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.912
supraoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.946359
hsa-miR-580	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
bone marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.141128
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.216528
CASP7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00440155
PSMC6	Pathway Commons Protein-Protein Interactions	1.0	null
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.30629
variant	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-3121-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
DROSHA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90776
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GHITM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49951
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
SRSF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06456
BBOX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00432033
CEP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04624
Kidney Chromophobe_KICH_TCGA-KN-8422-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11058205-42003_2024_6202_MOESM5_ESM.xlsx-Data2c_CEBPA_ChIP-Unnamed_9_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
decamethonium bromide-4094	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC38A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58192
HEXIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56813
r9 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58995
Acute Myeloid Leukemia_LAML_TCGA-AB-2806-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A172	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Integument	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
EXD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43572
BRD-K00359952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14447
DETROIT562	CCLE Cell Line Gene Expression Profiles	-1.0	-1.61116
meprylcaine-6123	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K36718828	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17158
GSE214248_0_v_1_cxcl8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Autosomal Recessive Retinitis Pigmentosa	DisGeNET Gene-Disease Associations	1.0	null
CRCGN017_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78261
BRD-K88190816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.402
BRD-K49704392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73868
NCI-H1437	GDSC Cell Line Gene Expression Profiles	1.0	2.81384
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.963
GLS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28081
BRD-K98245381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43746
CRCGN015_MCF10A_48H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06306
PMC11193738-41467_2024_48647_MOESM8_ESM.xlsx-Data_S5-Data_S5_HNF4A-bound_gene_targets_identified_from_ChIP-Seq_in_hepatic_cells_D8_Hep_and_HepG2_cells_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.049112
Colorectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
glutamine biosynthetic process	GO Biological Process Annotations 2023	1.0	null
WSU-NHL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4396-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H4C8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99858
A549_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201027
thyroid	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46784
SKMEL5	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.99617
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.3122
NUDT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68578
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.215534
Sarcoma_SARC_TCGA-IW-A3M5-01A-22R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
Glutamine synthetase, beta-Grasp	InterPro Predicted Protein Domain Annotations	1.0	null
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25143
INTS11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92783
DDX46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14252
RAD51C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.295
Spinal nucleus of the trigeminal, oral part, middle dorsomedial part, dorsal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0743
Lung adenocarcinoma_LUAD_TCGA-78-7167-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FREM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45262
PLXNC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00484546
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9384
CRCGN014_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15836
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.332
CLCN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20837
PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
PIDD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25554
OLIG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00492733
Reticular nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0743
NFE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38542
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19C-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53438
DBTRG05MG	DepMap CRISPR Gene Dependency	1.0	2.49623
C12orf29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89704
CRCGN016_MCF10A.TP53.M_24H:C10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04506
small intestine	HPA Tissue Gene Expression Profiles	-1.0	-0.969592
Gaucher's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
Lung adenocarcinoma_LUAD_TCGA-50-6594-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
2313287	DepMap CRISPR Gene Dependency	1.0	6.5431
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2332
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A4XK-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6B2-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A513-01A-12R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retrosplenial area, lateral agranular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59878
FUOM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.36677
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8029
KDM3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52728
Accessory olfactory bulb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1935
OCT4-21477851-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC12978397-wjon-17-02-247-s002.xlsx-S2-Suppl_2_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47352
RAF1_overexpression_220_GSE42964	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.27344
CCDC102A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4873
MUC3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88505
BRD-K19536737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31496
RPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49446
RUNX1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-23c	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
RAJI	DepMap CRISPR Gene Dependency	1.0	4.93341
BRD-K55598155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03052
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2617
hsa-miR-3679-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
496100497_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.34072
ELP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58008
PSMB8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7255
Pancreatic adenocarcinoma_PAAD_TCGA-LB-A8F3-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4427-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.9982
Omasum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.642
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11905
BRD-K08754235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59249
Telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00042
External ectoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.217
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.8706
BRD-K49526793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94905
CRCGN017_MCF10A.TP53.M_24H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8298
SLC17A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10644
superficial stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39225
ART5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40507
CHRNA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.84584
GATA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.082
NCIH1944	DepMap CRISPR Gene Dependency	1.0	3.42497
CRCGN014_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.58558
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02394
TCF23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6617
ZFX_KD_GSE43021_130_human_NOMO1	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
IFT27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98595
breast carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.167452
MRK-NU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RD	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Ureterocele	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
SFXN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97555
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4669
Bed nuclei of the stria terminalis, posterior division, principal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20003
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.992129
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7311
Lyf-1	MotifMap Predicted Transcription Factor Targets	1.0	null
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7421
Charcot-Marie-Tooth disease type 4F	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.423
BRD-K94685203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04616
H2AC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29913
depression	GWASdb SNP-Phenotype Associations	1.0	0.578018
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37716
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GB-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-5654-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K55606442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92199
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08855
kidney_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.37911
GSE147366_3_v_2_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.62933
BRD-K09511124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58459
GSE172019_2_v_8_rnf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
YY1_KD_GDS3788_488_human_HeLa	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K10541973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61979
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	1.0	1.47687
LARP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24247
intermediate stratum of r4Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01315
fleroxacin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30765
inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.49155
GSE211262,GSE211263_3_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
r9 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23742
organic acid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
ARMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66715
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.4305
BRD-K38694430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61885
UBE2D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03546
RNF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63489
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.1
Cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
TOV21G	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.04152
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12216
BRD-K60057192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23887
ELAVL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71096
A549_FLLL32_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151026
ALDH9A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0052964
BRD-K66299486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71332
Central amygdalar nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26193
NUGC-3	GDSC Cell Line Gene Expression Profiles	1.0	1.49913
Selinexor _NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0152151
NEUROD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32131
hsa-miR-3647-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.199275
Sarcoma_SARC_TCGA-SG-A849-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47906308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58125
ALEXANDERCELLS	CCLE Cell Line Gene Expression Profiles	1.0	1.63228
SRY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.31332
intermediate stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72908
A549_Resveratrol_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150269
A549_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138905
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.66
AKAP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11739
parabigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.03406
ZEB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4742
CA SKI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6151
EBF1-22473956-LYMPHODE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K69349031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22495
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.217554
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039986
duodenum	HPA Tissue Protein Expression Profiles	1.0	0.877031
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3214
BRD-K85656316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16459
MEG-01	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abnormal emotion/affect behavior	GWASdb SNP-Phenotype Associations	1.0	0.292599
PAPSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0682
fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.396087
r4 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01315
GSE113005_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
nucleus sagulum, superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10974
Lung adenocarcinoma_LUAD_TCGA-55-8092-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ammonia ligase activity	GO Molecular Function Annotations 2023	1.0	null
GRK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496252
Male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN017_MCF10A.WT.HP_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6752
IWS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87039
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DL-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TFEC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5687
BIN67	DepMap CRISPR Gene Dependency	1.0	2.3813
hsa-miR-1290	TargetScan Predicted Conserved microRNA Targets	1.0	0.034317
BRD-K15474464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46805
BRD-K76336129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29208
anterior pretectal nucleus, ventral superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72413
LC1F	CCLE Cell Line Gene CNV Profiles	1.0	2.17932
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21191
GOSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05725
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
Lung adenocarcinoma_LUAD_TCGA-97-8179-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156022
CRCGN014_HEPG2_3H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1619
INA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81016
RNASE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93825
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
WDR35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33564
superficial stratum of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28635
ERI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60162
SK-N-DZ	GDSC Cell Line Gene Expression Profiles	-1.0	-1.4688
BRD-K14037093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01756
PMC9894241-pnas.2211429119.sd05.xlsx-G6_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
outer CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.845897
Lens	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NFYA	ENCODE Transcription Factor Targets	1.0	null
ECGI10	CCLE Cell Line Gene CNV Profiles	1.0	2.33811
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26139
A549_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225362
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5982-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bile duct adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845906
KMS-12-BM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K95129711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04153
PRR35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4966
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
GATB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72717
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HCC70	DepMap CRISPR Gene Dependency	1.0	2.87331
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K97466946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05483
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH2172	CCLE Cell Line Gene CNV Profiles	1.0	1.72347
sphingolipidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.774932
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7786-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC25A44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10241
H3K27me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.49457
NCI-H2030	GDSC Cell Line Gene Expression Profiles	1.0	1.71614
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.39258
primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16295
fundus dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.789672
ZFPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06006
hsa-miR-3606	TargetScan Predicted Conserved microRNA Targets	1.0	0.026857
Mature cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.575
PRKAA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20151
AGXT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49361
outer CP in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.969764
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.4904
BRD-K17061569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25625
BRD-K07794261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52603
myoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.125783
USF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80094
pa317	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.374
BRD-K15343767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57373
BRD-K30895360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38654
CMYC-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MYH14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44772
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.66609
TMEM59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09076
ZNF23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10347
CAOV4	CCLE Cell Line Gene CNV Profiles	-1.0	-2.01867
SARS-BatSRBD_Day2_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.92675
NHLRC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50583
BRD-K50596260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21891
fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.578016
Lung squamous cell carcinoma_LUSC_TCGA-39-5011-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
morphological abnormality of the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.075453
KP1N	DepMap CRISPR Gene Dependency	1.0	3.76019
SYNGR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42307
BCORL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65478
CRCGN017_MCF10A.TP53.M_24H:E03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17945
PRKACA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33848
CYCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50858
Uterine Carcinosarcoma_UCS_TCGA-NF-A4WU-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
myelomonocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.564434
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.874875
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34846
BRD-K45974539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45066
NEUROG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.988
BRD-K14074563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11307
PRDM5-23873026-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE148262,GSE150691_3_v_2_hdlbp_human	RummaGEO Gene Perturbation Signatures	1.0	null
r4 part of medial paralemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17534
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4720-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GSE119978,GSE180930_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PCI-6A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Seedpod	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.648
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20631
outer CP in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07519
RUFY3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35245
Perturb_472_KD_ARAF_SRP259289	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.72273
JEG3	DepMap CRISPR Gene Dependency	1.0	2.6591
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12123
posteroventral (inferior) parietal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.916654
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TB-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13637593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27648
Brain stem	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.49072
PECAPJ15	DepMap CRISPR Gene Dependency	1.0	2.24012
IFIH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00601021
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.903692
BRD-K66425065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36607
ECGI10	DepMap CRISPR Gene Dependency	1.0	3.69608
496100324_FWM_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14185
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.372
BRD-K30025024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34732
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29825
A549_Selisistat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231845
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
OLFML2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54889
MDST8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15941
DEDD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67255
A549_Streptozotocin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017367
OSTM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21357
GALNT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01449
hsa-miR-4803	TargetScan Predicted Conserved microRNA Targets	1.0	0.09606
CAS1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.05005
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040482
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17401
MARCHF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01654
NCI-H1650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.67628
Kidney Chromophobe_KICH_TCGA-KN-8433-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K89440651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45367
ZFHX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549161
ILF3	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Cimetidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170313
BRD-K49094605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79604
UXT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1274
TAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80961
PHC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82962
superficial stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72413
HCC1569	CCLE Cell Line Gene CNV Profiles	1.0	1.46109
BRD-K12710356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1077
PU1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RC3H2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55941
BRD-K28165728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36494
CLDN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18135
A549_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117571
glutamine	GeneRIF Biological Term Annotations	1.0	null
RNF40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00259
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUPM2	DepMap CRISPR Gene Dependency	1.0	2.59384
Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
substantianigra	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.0488
GSTA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554931
orbital frontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.3182
ARHGEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55757
Refractive error	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.844884
PCYT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.41208
GSE242290_3_v_7_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100522_PCx_dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12195
CRCGN014_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78607
diagonal part of septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07593
primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.915137
c2c12 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.252261
PMC11426526-ppat.1012555.s011.xlsx-DEG_MDDC_Jurkat_LPS_vs_MDDC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Lens nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.868
r5 part of ventral lateral lemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71815
59M	CCLE Cell Line Gene Expression Profiles	-1.0	-2.88773
H3K27me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
alpha-amino acid metabolic process	GO Biological Process Annotations 2015	1.0	null
NPM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48386
intermediate stratum of RtC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26193
Orbital area, medial part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35124
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7388-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146546,GSE146807_0_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K11404512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0802
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1135
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11291
BRD-K94903598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040732
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25143
BRD-K12132610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03137
EXOSC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78429
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.110043
PRB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17076
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5891-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RN-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Subgeniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
BRD-K44932450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.629
BRD-K90918886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13811
mantle zone of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59878
BRD-K62497619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28754
RPSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32493
hsa-miR-197	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
ZNF541	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39605
CD244	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536699
CYP1B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00711765
NREP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69029
Perturb_16610_KO_Phb_SRP229743	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.876951
superficial stratum of r2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01315
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0418
CDX2-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
KPL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9015
BRD-K42671261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0925
ARAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21914
ZFP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.07033
A549_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148357
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.22415
r3 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11077
A549_Ruxolitinib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140538
virion	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.190814
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.880776
Lung squamous cell carcinoma_LUSC_TCGA-22-1017-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K14246348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37473
EOGT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44711
BRD-A84816049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20484
NZM42	DepMap CRISPR Gene Dependency	1.0	2.0623
orbital frontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	3.38633
Ebolavirus(ZEBOV)_1day_Spleen_None_GSE57214	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.02819
Gilles de la Tourette syndrome	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.717
GSE227592_0_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF595	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98876
Prostate adenocarcinoma_PRAD_TCGA-VN-A88L-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C1QBP	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K33456231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00417
eye	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Mel-18_KD_GDS2724_103_human_DAOY medulloblastoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
KLK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77323
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41Q-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.328628
Ciliary muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.779
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01803
ESRRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38978
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.33016
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.933381
BRD-K04371719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43657
hsa-miR-4307	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
Sense organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.3
pterigoid muscle trigeminal motor cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17401
abnormal neuron morphology	GWASdb SNP-Phenotype Associations	1.0	0.510092
USF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.74356
BRD-K04366109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82352
Central medial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05875
BRD-K92134254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05791
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.9005
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9053
CRCGN009_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.64767
BRD-K90801819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02467
PSMD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45586
VAMP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38192
testis	HPA Tissue Protein Expression Profiles	1.0	0.877031
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.06248
SYK_knockdown_279_GDS3609	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.3873
PMC6299095-41389_2018_108_MOESM4_ESM.xlsx-T47D-TRPS1_peak-gene_symbol_TRPS1	Rummagene Transcription Factor Associations 2026	1.0	null
pregeniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0743
BRPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86667
H2AZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70368
ALX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43293
placenta_3a	HPA Tissue Sample Gene Expression Profiles	1.0	0.956964
ZSCAN18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1641
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05792
SNRNP200	Pathway Commons Protein-Protein Interactions	1.0	null
bone marrow	HPA Tissue Protein Expression Profiles	-1.0	-1.30022
trimipramine-4163	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
BACH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7968
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46147
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2241
ZNF783	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46874
BRD-K25755601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01983
BRD-K46239950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93851
HCC1187	Achilles Cell Line Gene Essentiality Profiles	1.0	1.16011
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22934
SFSWAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43299
primary auditory cortex (core)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1135
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q9-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR3C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94227
A549_Fasudil_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208864
En-1	MotifMap Predicted Transcription Factor Targets	1.0	null
SIGMAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32873
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3387-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K29661539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27325
TMEM39B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43601
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.972773
hsa-miR-4303	TargetScan Predicted Conserved microRNA Targets	1.0	0.065994
ZBTB26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50547
CRCGN010_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19291
PMC13000489-mmc1.xlsx-Table_S3-Table_S3_LC_related_genes_screened_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00608
Mitotic spindle microtubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.546
Vestimentum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.333
Iris smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.772
organic substance biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Vertebrate muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN014_HEPG2_24H:H18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4437
BRD-K82118272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07128
prethalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05875
A549_Sodium Phenylbutyrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147547
CRCGN015_MCF10A.WT.HP_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00992
ZNF425	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99428
liminal reticular formation of m2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34479
tendon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.129719
mucopolysaccharidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.66199
CRCGN017_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62381
UBXN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9156
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.47946
prostate	HPA Tissue Protein Expression Profiles	1.0	0.877031
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K66963756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43258
NCIH1944	CCLE Cell Line Gene Expression Profiles	1.0	1.85003
BRD-K35288606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10104
LCOR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76563
superficial stratum of r3BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1114
BRD-A53381587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20402
Orbital area, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22202
NCAPH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07776
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NH-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K25710391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47407
HGC-27 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.646
MYC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76214
Biliary papillomatosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
PLEKHG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57965
Sarcoma_SARC_TCGA-SI-A71Q-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cSARS Bat SRBD_30Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.45304
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K54922310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5775
Perturb_6704_KD_LPA2_SRP057199	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.08814
SG in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10369
TP63_01_201	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.56282
eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.714189
CRCGN015_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71335
FOXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87254
mantle zone of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28635
FAM104B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95044
BRD-A39031631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87434
hippocampus	HPA Tissue Protein Expression Profiles	-1.0	-1.95975
Perturb_10638_Mut_Cryaa_SRP104440	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.54899
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
NBDY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.31018
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MS-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FAM200A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60822
Retinitis pigmentosa 25	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.707
Sarcoma_SARC_TCGA-QQ-A8VH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99555
ZNF513	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00786244
MCM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46929
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8535
Rectum adenocarcinoma_READ_TCGA-DC-6154-01A-31R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125155
hippocampus (hippocampal formation)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.39633
respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.273308
C18orf25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91657
intermediate part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.79436
acid-ammonia (or amide) ligase activity	GO Molecular Function Annotations 2015	1.0	null
ACHN	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.28492
A549_PCI-34051_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132673
COLO-829	COSMIC Cell Line Gene Mutation Profiles	1.0	null
AP2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00594
TRIM17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18328
CYP2S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15219
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.844884
BRD-K37151525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36811
GSE254649_2_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IGROV1	DepMap CRISPR Gene Dependency	1.0	3.07728
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
sublayer 6b of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0743
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47X-01A-31R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ANP32B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37973
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.382884
GSE240386,GSE242143_1_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20351
BRD-K75380271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15899
UBXN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63879
BRD-K50598383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64278
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.08223
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	53.3649
OXER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71094
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.975676
HNRNPH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.16852
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6937-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4325-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMEM120B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15158
Primary Malignant Neoplasm Of Lung	DisGeNET Gene-Disease Associations	1.0	null
BRD-K83270526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21416
OPTN_KD_GDS2892_268_human_HeLa	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BE-13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
skin cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067795
Inflammation	CTD Gene-Disease Associations	1.0	1.60291
Hypertrophy	CTD Gene-Disease Associations	1.0	1.07983
Brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
THYN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87374
lymphoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060801
metabolic process	GO Biological Process Annotations 2015	1.0	null
glutamine biosynthetic process	GO Biological Process Annotations 2025	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7351-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-AH-6897-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Divalproex Sodium_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150735
RAG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2346
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1395
LRRN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28007
CORO2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23119
H3K9me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
EGFR_OE_GDS1925_167_human_Estrogen receptor (ER) alpha positive MCF-7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CCDC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37958
Prostate adenocarcinoma_PRAD_TCGA-CH-5790-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UMPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86152
A549_Alisertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105639
BRD-K00950228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10517
A549_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201575
ZDHHC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47365
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6962-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU2AF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11033
virion part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.193394
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36744
GSE146982_4_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6137307-mmc2.xlsx-STAT2-IFNa-Table_S1_STAT2-IFNa_Related_to_Figures_1_4_STAT2	Rummagene Transcription Factor Associations 2026	1.0	null
RPS17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89676
NFE2L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00700847
Intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CDX2-21402776-INTESTINAL-VILLUS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
1321N1	CCLE Cell Line Gene CNV Profiles	1.0	2.02297
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5712-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of r5BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13685
FNBP1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48369
FHOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37771
NPAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47334
IGFLR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7619
r2 part of principal trigeminal sensory nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
kidney	HPA Tissue Gene Expression Profiles	1.0	1.37197
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K22875057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41821
rhombomere 10	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9092
STAU1_DELETION_GDS3370_56_human_HeLa	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BHLHE23	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0444
BRD-K79232672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48491
ZBED5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7337
TRIM52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00067
BRSK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90723
spleen	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.10282
EGFR_druginhibition_83_GSE27640	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.69079
MV411	Achilles Cell Line Gene Essentiality Profiles	1.0	1.00082
BRD-K56778317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19239
CASZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70972
TMEM186	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38442
Cholangiocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
Uterine Carcinosarcoma_UCS_TCGA-N5-A59E-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.25989
YD38	DepMap CRISPR Gene Dependency	1.0	3.95449
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9411
hsa-miR-1179	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
PICALM	Pathway Commons Protein-Protein Interactions	1.0	null
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	55.3735
SEC24B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80747
RPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97466
small molecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Retrochiasmatic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26193
RAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43237
KBTBD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60327
BRD-K94862255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32266
496100653_PCx_probable Alzheimer's disease_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.60037
GSE193258,GSE193259_5_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-506	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.717
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
JUN	ChEA Transcription Factor Targets	1.0	null
BRD-K54732353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64299
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052122
GSE192870_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6133-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lens fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.534
HOXD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4638
RUNX2	ChEA Transcription Factor Targets	1.0	null
HuH-7	GDSC Cell Line Gene Expression Profiles	1.0	1.57909
r3 part of reticulotegmental nucleus, shell portion	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05875
BRD-K69348766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54299
A549_TMP195_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186627
PITHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5925
PCDHB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01543
BRD-K80733946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47855
CCDC88C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9386
CRCGN013_HEPG2_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06424
NPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29703
A549_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154167
PMC10335698-pone.0285806.s007.xlsx-DMKN-shRNA_KD_Vs_ShSrc-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE90710_1_v_0_med13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0100187
Microphthalmia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.1805
RBBP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77478
withaferin A-3819	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07954
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0585
BRD-K04321001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44229
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.36817
SNU466	CCLE Cell Line Gene CNV Profiles	-1.0	-1.75167
PNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.28566
BRD-K76713927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15711
Central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pallidal septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43727
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2737
PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
DDX60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98238
layer VI of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07543
NCI 460	BioGPS Cell Line Gene Expression Profiles	1.0	0.982142
CNOT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.585
investigated	GeneRIF Biological Term Annotations	1.0	null
HSF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0968
BRD-K16525290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21904
BRD-K54151058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22274
BRD-K61242732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02081
intermediate stratum of m2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16989
NOA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25159
all	GWASdb SNP-Phenotype Associations	1.0	0.030298
BRD-K10452371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78328
hsa-miR-3529	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
ASMTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14155
EOLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08903
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053345
H3C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98491
RHOXF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96942
BRD-K97332312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00864
hsa-miR-767-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.471
CDK10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03474
mantle zone of r2Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
FASN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10876
FMR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2158
Lung adenocarcinoma_LUAD_TCGA-55-1596-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5587-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.102751
BRD-K56761719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33476
CD37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77802
LIME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68582
BICR22	DepMap CRISPR Gene Dependency	1.0	2.90158
SPATA25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.35807
LC-1-SQ	COSMIC Cell Line Gene CNV Profiles	1.0	2.76305
A549_ITSA-1_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185632
MAP3K6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65961
MKN7	GDSC Cell Line Gene Expression Profiles	-1.0	-2.38306
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3Z9-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4782
periventricular stratum of AStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59878
lateral terminal nucleus of the accessory optic tract, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.8675
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.82837
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0818
posterior (caudal) superior temporal cortex (area 22c)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34852
XPNPEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81745
FOXG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45586
H3K36me3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ITGA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12587
Agranular insular area, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
ZCCHC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69985
GSE138863_3_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K90527476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14854
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MDA-MB-231	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37864
Ileocecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ZNF334	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7893
rectum	HPA Tissue Protein Expression Profiles	1.0	0.877031
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5348
SPATS2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47929
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.2811
bed nucleus of stria terminalis, lateral amygdaloid division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
A549_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206144
Posterior parietal association areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59878
CRCGN016_MCF10A.TP53.M_24H:O23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01748
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
BRD-K33961669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02999
hsa-miR-590-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
Breast fibrosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.465
BRD-K60484506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.512
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4115-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LIN28B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE180185_7_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Tozasertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113704
SLC27A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77792
BRD-K07614312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19425
YH-13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Iris	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.638
MEIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3159
principal sensory nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.890805
BRD-K11310449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05639
PMC8494348-pone.0257161.s002.xlsx-only_D20_-_OXT_NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
ERICH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91864
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.829943
Agranular insular area, dorsal part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59878
CLPTM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39108
FANCM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4225
CRCGN011_HEPG2_24H:L17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2314
HOXD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25644
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
NCI-H820	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04346
GSE180951_1_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GPX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5823
FAM124B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49374
mantle zone of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12086
Lung adenocarcinoma_LUAD_TCGA-97-A4M2-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FLNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40881
Posterior parietal association areas, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.01476
GSE193258,GSE193259_5_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
glutamine synthetase activity	GO Molecular Function Annotations 2025	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.387781
Ebolavirus(ZEBOV)_3day_Liver_None_GSE57214	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.81635
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5459
HTRA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49281
SLR23	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.13739
GSE147366_3_v_5_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.8731
PMC8185471-mmc4.xlsx-hESC-DEGs_between_SOX15_KO_hESCs_and_WT_hESCs_cells_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
NECTIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15783
SOX2-22085726-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SKNSH	DepMap CRISPR Gene Dependency	1.0	2.45437
ARHGDIB_Transfection_GDS4455_551_human_UM-UC-3 bladder carcinoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
TE-6	GDSC Cell Line Gene Expression Profiles	-1.0	-1.85974
inner CP in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04399
A549_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0230932
lateral orbital frontal cortex (area 12/47)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34847
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A2C5-11A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08712
intermediate stratum of AStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11291
ZNF239	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73922
hsa-miR-576-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
SUPT6H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68747
DPPA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54405
BRD-K98374711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29706
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A4Z6-06A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4251	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
NCI-H1650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SLC22A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00639398
single-organism process	GO Biological Process Annotations 2015	1.0	null
OTX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51177
GFY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88334
SARS-dORF6_60Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.94292
hsa-miR-409-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
Inferior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.7021
ZBTB32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50521
ASH2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58569
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92445
liver_c	HPA Tissue Sample Gene Expression Profiles	1.0	1.23029
parasubicular cortex (parasubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.824123
ovary	HPA Tissue Protein Expression Profiles	-1.0	-2.7248
Orbital area, ventrolateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06058
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1403
BRD-K01417352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00609
GSE214335_1_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134918
hsa-miR-3907	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I2-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.238706
BRD-K62460895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09951
nih-3t3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.763226
Connective tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Central amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26193
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.957614
ORAI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58996
GSE147366_1_v_4_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Fatty Liver	CTD Gene-Disease Associations	1.0	1.11775
CRCGN010_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9996
DTYMK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91609
ammonia ligase activity	GO Molecular Function Annotations 2025	1.0	null
DLST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75714
myoblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.152972
A3KAW	DepMap CRISPR Gene Dependency	1.0	2.41634
MEIS1-26253404-OPTIC-CUPS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DIS3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50492
hsa-miR-342-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
BRD-K26233698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31764
BRD-K03214579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23839
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.923082
CAOV3	DepMap CRISPR Gene Dependency	1.0	4.75819
CTCF	ENCODE Transcription Factor Targets	1.0	null
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PSMB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07909
BRD-K86065375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11851
TrigeminalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.866902
ZFPM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22927
DDX50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68454
NANOG-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RBM48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34538
embryonic fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.672506
DNAJB14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21288
ZNF280B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00589264
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
CEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09549
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16954
JUN-21703547-K562-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
INTS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0479
Ovotestis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.546
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.45332
LMX1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46887
Reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.876951
HOXB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0486
FAM131B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30243
GSE102870_1_v_2_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.717
HSBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85116
CRCGN008_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14975
PRDM5-23873026-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF646	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78416
Lens disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.596
retromammillary area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01315
SP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41998
cerebellum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.883214
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.89305
RERFLCMS	CCLE Cell Line Gene Expression Profiles	1.0	1.35436
EHF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92793
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.1223
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0931
496100473_TCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0119
HCC2998	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.849184
glutamine family amino acid biosynthetic process	GO Biological Process Annotations 2025	1.0	null
best	GeneRIF Biological Term Annotations	1.0	null
BRD-K96547094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04245
BRD-K16643911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04771
depressive	GeneRIF Biological Term Annotations	1.0	null
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36744
JARID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32952
outer CP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3077
GOLGA6L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68182
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.13622
lens epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.458759
BRD-K60337438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06546
GSE158632_2_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K41033271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05732
PGF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54374
STAU1	Pathway Commons Protein-Protein Interactions	1.0	null
SPRY4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59441
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.26712
H4C16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93741
Mesothelioma_MESO_TCGA-LK-A4O4-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845906
LSM12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55621
TSPAN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21391
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.868918
LYAR	Pathway Commons Protein-Protein Interactions	1.0	null
eye	GeneRIF Biological Term Annotations	1.0	null
TBX20-22080862-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
placenta	HPA Tissue Gene Expression Profiles	1.0	1.11887
C2CD4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.44748
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.830293
Lung adenocarcinoma_LUAD_TCGA-97-A4M3-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11711664-41598_2025_85366_MOESM6_ESM.xlsx-AA-METABOLIC_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
OELE	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.11533
KLHL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33318
A549_Tozasertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148485
Tic disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.717
BRD-K81246784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12487
A549_PHA-680632_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167073
CARD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16943
ZSCAN5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2354
VHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65555
H3C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69885
ZFP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14807
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20947
Symbiosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.648
HOXB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3936
A549_Glesatinib(MGCD265)_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0255763
CTBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33791
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34564
BRD-K25351976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63989
hsa-miR-552	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Cardiovascular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Rectum adenocarcinoma_READ_TCGA-EI-6885-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87000197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36462
ZNF613	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6479
ETS1-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
JPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58441
BRD-K48412518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26707
A549_Ofloxacin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141151
NKX2-4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14555
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	1.0	0.915343
Age at first birth	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
A549_JQ1_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.019417
SMTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95441
lost	GeneRIF Biological Term Annotations	1.0	null
erythroleukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.391931
orbital frontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.53201
GNB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11103
Epilepsy	DisGeNET Gene-Disease Associations	1.0	null
r2 part of trigeminal sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
GATA2	ENCODE Transcription Factor Targets	1.0	null
GSE228181_4_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
layer IIIu of area 35r	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3293
endometrium	HPA Tissue Protein Expression Profiles	-1.0	-0.948935
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.28767
PTK7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00617056
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01082
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1479
Lung adenocarcinoma_LUAD_TCGA-73-4670-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TK-01A-42R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inner CP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01469
BRD-K52218664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99927
superficial stratum of CoPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86832
WDR83OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85793
NINJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87562
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.477367
DMPK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00598108
GSE203329_0_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DEK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73116
Myelomonocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.655
Male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HS2ST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74733
H1-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30108
ZNF135	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89956
SYNDIG1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61782
amygdaloid complex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.03139
gallbladder	HPA Tissue Protein Expression Profiles	1.0	0.877031
BRD-K79402882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83245
Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
hsa-miR-124	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
EKVX	BioGPS Cell Line Gene Expression Profiles	1.0	1.43209
snp	GeneRIF Biological Term Annotations	1.0	null
inner CP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.951553
hsa-miR-3924	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
rhombomere 9	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20301
BRD-K28512751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04671
TMEM86B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54581
PSN1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.826793
BRD-K02311826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00806
ID1_01_117	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60578
PAQR9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51747
BCAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50003
TMEM14C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85943
BRD-K31195910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11211
SART1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60364
ZBTB7C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89965
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.974643
BRD-K87930002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4831
BRD-K55393423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28577
intermediate stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45291
A549_Iniparib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208339
hsa-miR-4766-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
MYL12B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17776
BRD-A94420133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23244
LS513	Achilles Cell Line Gene Essentiality Profiles	1.0	1.25173
BBLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.85485
CRCGN016_MCF10A.TP53.M_24H:F11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24127
primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.86793
LYNX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24591
RFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19114
NUDT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47828
MONO-MAC-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
dihydroergotamine-mesylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5114
POLG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68588
HT1376	DepMap CRISPR Gene Dependency	1.0	3.40443
HNRNPR	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-7109-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5766-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PXDNL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93826
A549_Mocetinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137721
NCI-H1355	GDSC Cell Line Gene Expression Profiles	1.0	1.76706
BRD-K54979104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11162
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
ISCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.36115
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Rectum adenocarcinoma_READ_TCGA-AG-3725-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C6orf141	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74672
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053038
SPTAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8119
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.104614
POGZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0862
HCC1954	CCLE Cell Line Gene CNV Profiles	1.0	1.79446
CHRNA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13968
butyrylcholine-cl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00896
BRD-A05635986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.64016
ASTE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.57093
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.81656
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
Diabetic cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
enzyme	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4652-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
BRD-A59683007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38128
SALL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97003
MRPS21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93638
IRX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09264
CRCGN015_MCF10A_48H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30748
H3K27me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Orbital area, medial part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6684
PMC9894241-pnas.2211429119.sd05.xlsx-G7_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
RNF20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63713
M059K	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28518
A549_Trametinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0322641
Brain Lower Grade Glioma_LGG_TCGA-HT-7855-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
20421987-TableS4	GeneSigDB Published Gene Signatures	1.0	null
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cataract 44	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.659
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.876951
BRD-K21443215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.35979
r9 part of trigeminal transition zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10353
sense organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
intermediate stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40448
POLI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35047
lateral part of MM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26193
GSE70935_2_v_0_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.6152
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1429
CRCGN011_HEPG2_24H:L15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.051
H2AB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8037
PA-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ATOH8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43052
posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32116
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.5899
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.897257
CTRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56373
ZNG1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33167
COLO741	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43513
SNRPB	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K54881917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.29042
CXCR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75403
GSE125219,GSE125221_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Retrosplenial area, lateral agranular part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0743
Linear nucleus of the medulla	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01223
Forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K22390389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19019
MDAMB435S	CCLE Cell Line Gene CNV Profiles	1.0	1.80926
RSRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20986
BRD-K47804666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03216
lymphocytic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063986
BRD-K75136523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27743
Lung adenocarcinoma_LUAD_TCGA-55-7727-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182179_0_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
GSS	DepMap CRISPR Gene Dependency	1.0	2.25266
CRCGN010_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18555
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.869289
NR3C1	JASPAR Predicted Transcription Factor Targets	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.271
eye and adnexa disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047869
class	GeneRIF Biological Term Annotations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5581-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBE2I	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58814
synovium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.151157
CRCGN017_MCF10A.WT.HP_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.656
NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
RBM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84485
A549_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136851
BRD-K77751431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85182
Orbital area, medial part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34479
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TB-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144277
superior periolivary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.14984
Accessory olfactory bulb, mitral layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26596
Chromosome Aberrations	CTD Gene-Disease Associations	1.0	1.32162
DHX9	Pathway Commons Protein-Protein Interactions	1.0	null
TCCPAN2	DepMap CRISPR Gene Dependency	1.0	2.95943
SLC9A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59097
ABI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.36399
DIRAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30832
Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KW-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
terminal nucleus of the stria medullaris	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59516
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0669
COX7A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40733
496100510_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.1314
EPCAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40051
Lung adenocarcinoma_LUAD_TCGA-78-7150-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K06911479	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05243
SK-MEL-5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
glutamine metabolic process	GO Biological Process Annotations 2025	1.0	null
CL11	DepMap CRISPR Gene Dependency	1.0	3.51422
POU3F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45436
TOP2B-26459242-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
tendon sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.143375
NCIH1339	CCLE Cell Line Gene CNV Profiles	1.0	1.56285
Mucopolysaccharidosis IV	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.22
SDR42E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28626
Sarcoma_SARC_TCGA-SI-AA8C-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K23963854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07577
ORC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92685
lambdoid septal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04067
Selinexor _NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00735983
LTB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552342
Gall bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
DU-145	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K71414336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12099
BRD-K85051145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76113
AOB, outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44661
melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069508
Adrenal gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CSNK2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16079
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
REH	Achilles Cell Line Gene Essentiality Profiles	1.0	1.10489
BRD-K26976202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5075
hsa-miR-182	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
MAML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19806
small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
CXCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76537
peripeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17401
SCRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52449
Lung squamous cell carcinoma_LUSC_TCGA-60-2714-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSPA1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30301
OVCAR8	CCLE Cell Line Gene CNV Profiles	1.0	1.51506
BRD-K23593468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36189
Depressive Disorder, Major	HuGE Navigator Gene-Phenotype Associations	1.0	null
Ciliary body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.87
CFL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00689292
r10 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.21022
SH3PXD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45031
EXO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75232
BRD-K49472569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57862
NASP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28812
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1702
H3K9me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SRF	JASPAR Predicted Transcription Factor Targets	1.0	null
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9724
SLC27A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02024
Infralimbic area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26907
hsa-miR-4513	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Lung squamous cell carcinoma_LUSC_TCGA-NK-A5CT-01A-31R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K06116445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87925
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4678
PRKX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26753
IGR37	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46617
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RJ-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AN3 CA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.963007
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
RCCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12788
BRD-K63800697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32916
VPS25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90708
HCC364	Achilles Cell Line Gene Essentiality Profiles	1.0	1.1725
LTF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91972
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7485
A549_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242979
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-579	TargetScan Predicted Conserved microRNA Targets	1.0	0.078844
SUZ12-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A681-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6366-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_10_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MORF4L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82037
HIGD2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5511
Geniculate group, ventral thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0743
GSE192870_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.996781
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4775	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.78089
BRD-K30761927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47413
PTRHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81116
BRD-K54100265	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25397
Perturb_527_KD_RUNX3_SRP201921	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
antigen	GeneRIF Biological Term Annotations	1.0	null
OCIP5X	DepMap CRISPR Gene Dependency	1.0	2.17966
CRCGN009_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.44856
lens	GeneRIF Biological Term Annotations	1.0	null
BRD-K83690550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65482
BRD-K24070365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05967
FOXO3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10733
form	GeneRIF Biological Term Annotations	1.0	null
biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BRD-K86586698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34444
striohypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47804
layer 2 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13951
Lung adenocarcinoma_LUAD_TCGA-55-8085-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GJA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33669
Primary somatosensory area, lower limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26193
CENPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87922
PNMA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61779
BRD-K24382357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15417
Ventral sucker	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.74
SAP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02174
SLC39A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92257
PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0073
Ventral premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17401
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
A549_UNC1999_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142482
DAGLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70395
ESD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8107
SP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.843655
GSE138050,GSE148257_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LN18	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.34026
diclazuril	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75555
COV434	Achilles Cell Line Gene Essentiality Profiles	-1.0	-3.20002
BRD-K32476586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92394
BRD-K54224946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08343
Lung adenocarcinoma_LUAD_TCGA-55-7913-01B-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DNAJB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21101
hsa-miR-339-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1203
GSE197555_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NADK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07369
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NA-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gaucher's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.988535
HDAC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1341
Lung squamous cell carcinoma_LUSC_TCGA-21-5787-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VRK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68677
SYNCRIP	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A42246453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14903
GAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39123
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF680	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8255
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ING2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35527
BRD-K06332513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65715
CYP2U1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05524
PRDM5	ChEA Transcription Factor Targets	1.0	null
SW48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RGPD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34455
SEPSECS	Pathway Commons Protein-Protein Interactions	1.0	null
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053736
LRRC8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45431
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.848314
A549_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178466
hsa-miR-4288	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6022-01A-21R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRIX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06304
CLCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17448
outer CP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.873097
BRD-K06698399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15727
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4444
ACOT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32172
LAGE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66501
BRD-K74826740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26718
BRD-K08811598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38367
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36744
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
STX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44238
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.950537
HUH7	CCLE Cell Line Gene Expression Profiles	1.0	1.90554
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058465
r10 portion of the hypoglossal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15394
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51E-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49325049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16622
ABCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2641
embryonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.581218
TP53_01_37	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.6359
ZNF469	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9927
Spinal nucleus of the trigeminal, oral part, caudal dorsomedial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59878
frontalcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.944818
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.5454
GSE138863_2_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
NARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60528
breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.048977
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
Myopia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.835234
Large intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
C17orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39327
A549_Aminoglutethimide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177361
MOLP2	CCLE Cell Line Gene CNV Profiles	1.0	1.92726
A549_Mocetinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159376
hsa-miR-632	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE168797_1_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YBX3	Pathway Commons Protein-Protein Interactions	1.0	null
SLC25A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67744
SRSF7_02_06	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.5025
Lung squamous cell carcinoma_LUSC_TCGA-85-8584-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
diethylstilbestrol-4369	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC16A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57756
BRD-K12918607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05877
ZNF414	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12029
Myelomonocytic Leukemia	DisGeNET Gene-Disease Associations	1.0	null
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.8112
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.03034
HDAC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54699
MDA-MB-453	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SSH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38294
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51N-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K32680124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09907
H3K27me3_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ligase activity	GO Molecular Function Annotations 2015	1.0	null
HUPT3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55871
BRD-K64055724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28042
PMC9424213-41467_2022_32537_MOESM5_ESM.xlsx-HeLa_IER3-AS1sh_DEGs-DEGs_in_HeLa_IER3-AS1sh_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HAGH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81742
ventral posterolateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
Lung adenocarcinoma_LUAD_TCGA-50-5930-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bacteriocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.679
inner CP in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.995935
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARRDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10798
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7353-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
kidney_d	HPA Tissue Sample Gene Expression Profiles	1.0	0.930511
hsa-miR-3613-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE80182_2_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
layer 1 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42827
PMC9883165-41375_2022_1744_MOESM3_ESM.xlsx-RNA-Seq_of_CEBPA_specific_genes-RNA-Seq_analysis_of_genes_associated_with_a_DHS_that_has_a_CEBPAx2_specific_Hi-C_interaction_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3607-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
Female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Lung adenocarcinoma_LUAD_TCGA-55-7815-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RORA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44294
Prestwick-1080-3796	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MDAMB231	CCLE Cell Line Gene CNV Profiles	1.0	1.52595
Lung adenocarcinoma_LUAD_TCGA-95-A4VK-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Accessory olfactory bulb, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24879
BEN	CCLE Cell Line Gene Expression Profiles	1.0	1.47801
FAM124A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67868
ventrolateral prefrontal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34852
A172	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.54074
Bulbourethral gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.619
DDX28	Pathway Commons Protein-Protein Interactions	1.0	null
ACD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7402
ZNF440	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33234
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041659
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.01832
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.2863
Ventral part of the lateral geniculate complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59878
BRD-K21707058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26332
A549_Tucidinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.020162
PMC11192681-11033_2024_9703_MOESM1_ESM.xlsx-common_ZFPs-C2H2-ZNF_genes_commonly_appearing_as_DEGs_WT_vs_SETDB1_KO_cells_in_HAP1_and_293T_cells_SETDB1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A80081229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32687
RAVER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03953
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular amino acid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.78089
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SETD1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00491424
CRCGN014_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35125
TAGLN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64263
TBX19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27427
BRD-K42199095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07733
BAZ2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16259
ZKSCAN1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2452	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K04147413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06708
mental depression	GWASdb SNP-Disease Associations	1.0	0.439363
retinitis pigmentosa	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.527676
POLK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61647
UBR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09696
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
A549_Divalproex Sodium_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136164
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
genomewide	GeneRIF Biological Term Annotations	1.0	null
Lennox-Gastaut Syndrome	DisGeNET Gene-Disease Associations	1.0	null
GSE168797_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Tazemetostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126937
BRD-K56950366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19695
BRD-K46994278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3188
HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6051
MOCS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30584
SAP130	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74503
BRD-K31987278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11085
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.41
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.47379
SOX2	ChEA Transcription Factor Targets	1.0	null
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22279
HOXC8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6502
BRD-A77440546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63119
superficial stratum of r5BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47842
Adrenocortical carcinoma_ACC_TCGA-OR-A5JW-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBX20-22328084-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NCI-H748	COSMIC Cell Line Gene Mutation Profiles	1.0	null
nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-4773	TargetScan Predicted Conserved microRNA Targets	1.0	0.199275
A549_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0101063
PDE12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98161
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.53815
ATF3-23680149-GBM1-GSC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PITPNM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03922
Barhl2	MotifMap Predicted Transcription Factor Targets	1.0	null
JADE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27103
TT2609-C02	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN008_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1588
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.876151
18318837-TableS1	GeneSigDB Published Gene Signatures	1.0	null
hsa-miR-4329	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
major depressive disorder	GWASdb SNP-Disease Associations	1.0	0.674534
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040264
MLLT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09952
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.870897
GSE180951_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.466
P32-ISH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
striatal amygdala	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
PAK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.13253
LXR-22158963-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TC71	DepMap CRISPR Gene Dependency	1.0	4.69304
ESET-19884257-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
alar plate of p3 (alar prethalamus)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05875
SCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98393
PTCD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36076
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1685
CDC42SE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61871
hsa-miR-328	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
cell part	GO Cellular Component Annotations 2015	1.0	null
AOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8909
BRD-K91799761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77626
BRD-K62572662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6089
PMC8530322-pone.0258316.s002.xlsx-GG_778_no-AA_778_no-Symbol_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N8-A56S-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1355	CCLE Cell Line Gene Expression Profiles	1.0	1.57229
GPI-PLD_OE_GDS2049_176_human_Hepatoma HepG2 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
bone marrow cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.143131
A549_Danusertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137404
BRD-K59667434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65308
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.52077
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	1.0	5.55642
L3MBTL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2108
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A22089150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74796
TNPO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86957
hsa-miR-4310	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
Lung	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Primary somatosensory area, mouth, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01315
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042771
BICR78	DepMap CRISPR Gene Dependency	1.0	10.5682
SCCOHT1	DepMap CRISPR Gene Dependency	1.0	2.04481
carboxylic acid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BRD-K58534227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7954
A549_PFI-1_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140351
RPL22L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77984
YBX2	Pathway Commons Protein-Protein Interactions	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051019
hsa-miR-607	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
LOX-1_OE_GDS4262_432_human_HAECT - aortic endothelial cell line - 2 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
hsa-miR-620	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
DHX30	Pathway Commons Protein-Protein Interactions	1.0	null
CCDC28B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02859
ZNRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5505
PHARC syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
BRD-K88224221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29711
GSE174701_4_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K39087188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22235
PER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39762
MRPL53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50691
Rectum adenocarcinoma_READ_TCGA-F5-6812-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4509	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Eye	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.3
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
drug dependence	GWASdb SNP-Disease Associations	1.0	0.600463
Intrinsic component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.206
NB13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DNM2	Pathway Commons Protein-Protein Interactions	1.0	null
ELP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84454
LN428	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.12773
Prostate gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
NCI-H1793	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29128
Primary somatosensory area, upper limb, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59878
SERBP1	Pathway Commons Protein-Protein Interactions	1.0	null
oxaliplatin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54992
branch	GeneRIF Biological Term Annotations	1.0	null
STAT3-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MEF2A	JASPAR Predicted Transcription Factor Targets	1.0	null
SUZ12-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2940-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CFAP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65209
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K32431589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30859
CRCGN012_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8605
GSE101467_0_v_1_dock8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HNRNPDL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11452
ARG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7088
NCI-H23	GDSC Cell Line Gene Expression Profiles	1.0	1.83781
GSE171837_1_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PACS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06337
temporal muscle trigeminal motor cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26193
Ileal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.513
TE-8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DNASE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93324
amygdalo-striatal transition	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59878
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5696-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRKAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94127
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8107
BRD-K41331757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06904
TCP10L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26109
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.05872
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6090-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A76X-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-490-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
amygdaloid complex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13066
SULT4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11833
Posterodorsal preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22104
Posterior parietal association areas, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0743
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
malespecific	GeneRIF Biological Term Annotations	1.0	null
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18526
EVSAT	DepMap CRISPR Gene Dependency	1.0	4.20021
ZC3HAV1	Pathway Commons Protein-Protein Interactions	1.0	null
Specific developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.717
PMC4487811-mmc3.xlsx-siRE_enriched_geneLists-siRE_occupancy_pattern_gene_lists_after_RUNX1_ETO_knock_down_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8671
NAA35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.52684
8505C	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K50053371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18753
VAC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55793
esophagus	HPA Tissue Gene Expression Profiles	-1.0	-0.969592
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GH-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
AGL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95729
Imago	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.86
UHRF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.23322
liver	GTEx Tissue Gene Expression Profiles	1.0	1.23671
CRCGN017_MCF10A.WT.HP_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1871
oseltamivir-phosphate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23931
GEMIN4	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WV-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FLNA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77218
tf-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.614571
hsa-miR-3646	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
A549_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158972
E2F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9941
SOX2-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
superficial stratum of DgSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14645
central amygdaloid nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39183
NCI-H522	GDSC Cell Line Gene Expression Profiles	1.0	2.01922
Intergeniculate leaflet of the lateral geniculate complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0743
ATF3-23680149-GBM1-GSC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0743
Head	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bach1::Mafk	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.2895
SLC6A15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44948
layer 1 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05875
response to nutrient levels	GO Biological Process Annotations 2023	1.0	null
BRD-K38434557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01743