association	dataset	threshold value	standardized value
Seh1-associated complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.402
PI3K-Akt signaling pathway	KEGG Pathways 2026	1.0	null
TNF signaling pathway	KEGG Pathways 2026	1.0	null
FoxO signaling pathway	KEGG Pathways 2026	1.0	null
GTEx AdrenalGland 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	3.58892
E2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4608
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.9057
GSE221327_1_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	142.319
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6242
GSE131649_4_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Focal epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
Coronavirus disease - COVID-19	KEGG Pathways 2026	1.0	null
Renal cell carcinoma	KEGG Pathways 2026	1.0	null
Alzheimer disease	KEGG Pathways 2026	1.0	null
cAMP signaling pathway	KEGG Pathways 2026	1.0	null
Toll-like receptor signaling pathway	KEGG Pathways 2026	1.0	null
MGA::EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8803
GSE174498,GSE174500_0_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.2143
Pathways in cancer	KEGG Pathways 2026	1.0	null
MicroRNAs in cancer	KEGG Pathways 2026	1.0	null
Eukaryotic translation initiation factor 3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.112
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.642
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AGE-RAGE signaling pathway in diabetic complications	KEGG Pathways 2026	1.0	null
Non-alcoholic fatty liver disease	KEGG Pathways 2026	1.0	null
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
Neuroectodermal tumor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.425
HIF-1 signaling pathway	KEGG Pathways 2026	1.0	null
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Endometrial cancer	KEGG Pathways 2026	1.0	null
HSF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4389
Melanoma	KEGG Pathways 2026	1.0	null
GATOR1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.481
GSE213228_4_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6111
Fc gamma R-mediated phagocytosis	KEGG Pathways 2026	1.0	null
Hepatitis B	KEGG Pathways 2026	1.0	null
Insulin resistance	KEGG Pathways 2026	1.0	null
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST12-Unnamed_8_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Focal adhesion	KEGG Pathways 2026	1.0	null
Hepatitis C	KEGG Pathways 2026	1.0	null
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.9469
Neutrophil extracellular trap formation	KEGG Pathways 2026	1.0	null
Phospholipase D signaling pathway	KEGG Pathways 2026	1.0	null
GSE213228_1_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Estrogen signaling pathway	KEGG Pathways 2026	1.0	null
Choline metabolism in cancer	KEGG Pathways 2026	1.0	null
Fc epsilon RI signaling pathway	KEGG Pathways 2026	1.0	null
GSE216043_10_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Acute myeloid leukemia	KEGG Pathways 2026	1.0	null
Bacterial invasion of epithelial cells	KEGG Pathways 2026	1.0	null
Leukocyte transendothelial migration	KEGG Pathways 2026	1.0	null
Integrin signaling	KEGG Pathways 2026	1.0	null
Cholinergic synapse	KEGG Pathways 2026	1.0	null
GSE174498,GSE174500_3_v_4_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.369
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7159
Herpes simplex virus 1 infection	KEGG Pathways 2026	1.0	null
Colorectal cancer	KEGG Pathways 2026	1.0	null
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.4931
Sphingolipid signaling pathway	KEGG Pathways 2026	1.0	null
Ras signaling pathway	KEGG Pathways 2026	1.0	null
Platelet activation	KEGG Pathways 2026	1.0	null
Human T-cell leukemia virus 1 infection	KEGG Pathways 2026	1.0	null
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3221
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9856
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Epstein-Barr virus infection	KEGG Pathways 2026	1.0	null
Amoebiasis	KEGG Pathways 2026	1.0	null
Apoptosis	KEGG Pathways 2026	1.0	null
Chagas disease	KEGG Pathways 2026	1.0	null
Autophagy - animal	KEGG Pathways 2026	1.0	null
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3662
Proteoglycans in cancer	KEGG Pathways 2026	1.0	null
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9099
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.9889
Chemical carcinogenesis - reactive oxygen species	KEGG Pathways 2026	1.0	null
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.7466
C-type lectin receptor signaling pathway	KEGG Pathways 2026	1.0	null
IgSF CAM signaling	KEGG Pathways 2026	1.0	null
Osteoclast differentiation	KEGG Pathways 2026	1.0	null
Viral carcinogenesis	KEGG Pathways 2026	1.0	null
Prostate cancer	KEGG Pathways 2026	1.0	null
PMC8872993-41380_2021_1274_MOESM4_ESM.xlsx-Table_S6-Supplementary_Table_S6_Differentially-Expressed_Genes_after_T-3_KD_in_hiPSC-derived_Astrocytes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7091
Diabetic cardiomyopathy	KEGG Pathways 2026	1.0	null
Shigellosis	KEGG Pathways 2026	1.0	null
Phosphatidylinositol signaling system	KEGG Pathways 2026	1.0	null
E2F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3175
GSE163282_12_v_10_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Human cytomegalovirus infection	KEGG Pathways 2026	1.0	null
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Signaling pathways regulating pluripotency of stem cells	KEGG Pathways 2026	1.0	null
GSE158182_5_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102505_5_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Regulation of actin cytoskeleton	KEGG Pathways 2026	1.0	null
Influenza A	KEGG Pathways 2026	1.0	null
Chronic myeloid leukemia	KEGG Pathways 2026	1.0	null
Gastric cancer	KEGG Pathways 2026	1.0	null
Growth hormone synthesis, secretion and action	KEGG Pathways 2026	1.0	null
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Regulation of lipolysis in adipocytes	KEGG Pathways 2026	1.0	null
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.1022
Longevity regulating pathway - multiple species	KEGG Pathways 2026	1.0	null
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cellular senescence	KEGG Pathways 2026	1.0	null
Natural killer cell mediated cytotoxicity	KEGG Pathways 2026	1.0	null
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.8098
Inflammatory mediator regulation of TRP channels	KEGG Pathways 2026	1.0	null
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3777
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.445
GSE216043_3_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Type II diabetes mellitus	KEGG Pathways 2026	1.0	null
Small cell lung cancer	KEGG Pathways 2026	1.0	null
Spinocerebellar ataxia	KEGG Pathways 2026	1.0	null
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9467
Chemokine signaling pathway	KEGG Pathways 2026	1.0	null
mTOR signaling pathway	KEGG Pathways 2026	1.0	null
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1217
Hepatocellular carcinoma	KEGG Pathways 2026	1.0	null
VEGF signaling pathway	KEGG Pathways 2026	1.0	null
Carbohydrate digestion and absorption	KEGG Pathways 2026	1.0	null
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1341
GSE163282_0_v_5_aspirin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PD-L1 expression and PD-1 checkpoint pathway in cancer	KEGG Pathways 2026	1.0	null
Breast cancer	KEGG Pathways 2026	1.0	null
B cell receptor signaling pathway	KEGG Pathways 2026	1.0	null
Axon guidance	KEGG Pathways 2026	1.0	null
GnRH secretion	KEGG Pathways 2026	1.0	null
Chemical carcinogenesis - receptor activation	KEGG Pathways 2026	1.0	null
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Fluid shear stress and atherosclerosis	KEGG Pathways 2026	1.0	null
Relaxin signaling pathway	KEGG Pathways 2026	1.0	null
GSE218060_7_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Aldosterone-regulated sodium reabsorption	KEGG Pathways 2026	1.0	null
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6554
Human papillomavirus infection	KEGG Pathways 2026	1.0	null
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hormone signaling	KEGG Pathways 2026	1.0	null
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6032
Yersinia infection	KEGG Pathways 2026	1.0	null
JAK-STAT signaling pathway	KEGG Pathways 2026	1.0	null
Non-small cell lung cancer	KEGG Pathways 2026	1.0	null
GSE144120_3_v_1_plcg2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Thyroid hormone signaling pathway	KEGG Pathways 2026	1.0	null
GSE148321,GSE169423_2_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149621_2_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE218060_7_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Longevity regulating pathway	KEGG Pathways 2026	1.0	null
GSE188382_4_v_0_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Progesterone-mediated oocyte maturation	KEGG Pathways 2026	1.0	null
Glioma	KEGG Pathways 2026	1.0	null
Kaposi sarcoma-associated herpesvirus infection	KEGG Pathways 2026	1.0	null
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.4714
GSE116492,GSE116495_3_v_2_stag2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144484_2_v_1_mllt6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE185744,GSE185747_2_v_3_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174498,GSE174500_5_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Insulin signaling pathway	KEGG Pathways 2026	1.0	null
AMPK signaling pathway	KEGG Pathways 2026	1.0	null
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.394
GSE193402_0_v_4_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Measles	KEGG Pathways 2026	1.0	null
GSE176008_0_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pancreatic cancer	KEGG Pathways 2026	1.0	null
GSE209898,GSE209899_0_v_1_flcn_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE231829_0_v_1_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE209898,GSE209899_0_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neurotrophin signaling pathway	KEGG Pathways 2026	1.0	null
Prolactin signaling pathway	KEGG Pathways 2026	1.0	null
Central carbon metabolism in cancer	KEGG Pathways 2026	1.0	null
Human immunodeficiency virus 1 infection	KEGG Pathways 2026	1.0	null
Rap1 signaling pathway	KEGG Pathways 2026	1.0	null
GSE236497,GSE236500_1_v_0_pemrametostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lipid and atherosclerosis	KEGG Pathways 2026	1.0	null
GSE201270,GSE201272_5_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171352_2_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prion disease	KEGG Pathways 2026	1.0	null
T cell receptor signaling pathway	KEGG Pathways 2026	1.0	null
ErbB signaling pathway	KEGG Pathways 2026	1.0	null