association dataset threshold value standardized value GSE129293_0_v_1_chd4_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN016_MCF10A.WT.HP_24H:D19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.18875 Cellular bud neck COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.557 GSE195568_2_v_0_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE128730_3_v_1_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.99585 GSE261563_5_v_1_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null GSE217776,GSE217829_2_v_6_sgf29_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_5600_KD_ESCCAL1_SRP259187 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE205163,GSE205164_3_v_7_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null GSE247230_0_v_1_anp32b_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_2605_OE_SEPTIN9_SRP159553 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.30164 DAOY cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.579 CRCGN016_MCF10A.WT.HP_24H:B23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.07322 FERD3L JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.2596 GSE149035_1_v_0_hepacam_human RummaGEO Gene Perturbation Signatures -1.0 null GSE149359_2_v_0_asap2_human RummaGEO Gene Perturbation Signatures 1.0 null negative regulation of gluconeogenesis GO Biological Process Annotations 2025 1.0 null Skeletal muscle satellite cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.515 GSE160304,GSE163392_4_v_3_zswim8_human RummaGEO Gene Perturbation Signatures -1.0 null Cellular anatomical entity COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Pineal gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.134 GSE205163,GSE205164_3_v_0_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null GSE258991_1_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Hepatocarcinogenesis DisGeNET Gene-Disease Associations 1.0 null Perturb_422_KD_FOXM1_SRP371675 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -13.7311 FF-86-NH56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.366819 Spleen TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Pancreatic Carcinoma DisGeNET Gene-Disease Associations 1.0 null Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE158834_2_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GSE152441,GSE152442_1_v_3_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ZFP57 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.5433 striated muscle cell differentiation GO Biological Process Annotations 2025 1.0 null GSE157894_1_v_0_cystine_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN017_MCF10A.WT.HP_24H:A15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0671 CRCGN014_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.417 GSE242083,GSE242098_2_v_5_med1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE118077_1_v_8_sprr5_human RummaGEO Gene Perturbation Signatures 1.0 null TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.3152 GSE233679_6_v_3_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE125014_1_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null BB-87-SF89_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.324046 Flexor tendon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.509 CRCGN015_HEPG2_48H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.45657 GC-04-UF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.217368 GSE233679_6_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE193402_0_v_1_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE94849_7_v_0_pinometostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE157894_1_v_3_cystine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE199092_2_v_0_ddx5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE202434,GSE202438_13_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null Adenocarcinoma DisGeNET Gene-Disease Associations 1.0 null ZNF343 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 55.0929 GSE188382_4_v_0_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE146546,GSE146807_0_v_1_igf2bp1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE211262,GSE211263_2_v_1_pbrm1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE201309_1_v_2_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE239688_2_v_3_canagliflozin_human RummaGEO Drug Perturbation Signatures -1.0 null ZNF331 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.0876 GSE242555_1_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null YA-92-YO01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.242234 regulation of myotube differentiation GO Biological Process Annotations 2025 1.0 null GSE207787_3_v_2_pdha1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE237053_1_v_0_comt_human RummaGEO Gene Perturbation Signatures -1.0 null GSE233679_6_v_8_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null Nucleus COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GSE199204,GSE211619_4_v_6_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE185865_0_v_1_celf6_human RummaGEO Gene Perturbation Signatures -1.0 null regulation of mitotic cell cycle GO Biological Process Annotations 2025 1.0 null GSE149901_2_v_0_anlotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE235701,GSE261434_2_v_1_enasidenib_human RummaGEO Drug Perturbation Signatures 1.0 null BA-86-AL61_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.223848 GSE195568_2_v_10_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null Embryonic structure TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.052 GSE178714_1_v_4_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE132369,GSE132371_4_v_0_cccp_human RummaGEO Drug Perturbation Signatures 1.0 null GSE207514,GSE207515_2_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE197850_4_v_0_glucagon_human RummaGEO Drug Perturbation Signatures 1.0 null GSE95077_1_v_0_amiloride_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_HEPG2_48H:P22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.27045 CB-16-SY72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.306844 GSE70935_3_v_5_cyfip1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE206516,GSE206518_0_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null AR4-2J cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.529 MutS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.708 Las1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.844 GSE215086_8_v_7_batf_human RummaGEO Gene Perturbation Signatures 1.0 null PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2 Rummagene Transcription Factor Associations 2026 1.0 null GSE206784_2_v_4_ninl_human RummaGEO Gene Perturbation Signatures -1.0 null PMC11237048-41598_2024_64364_MOESM1_ESM.pdf-21-ENSG00000162599_NFIA Rummagene Transcription Factor Associations 2026 1.0 null FB-66-UU47_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.223215 Septin ring COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.535 GSE217452_3_v_1_docetaxel_human RummaGEO Drug Perturbation Signatures -1.0 null GSE163297_0_v_2_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null Integral component of lumenal side of endoplasmic reticulum membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.537 Perturb_374_KD_DHX16_SRP309315 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 15.8307 Sid2-Mob1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.585 GSE202434,GSE202438_12_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE235066_4_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null SP8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 198.484 CRCGN015_MCF10A_48H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.0552 GSE209911_0_v_1_ncstn_human RummaGEO Gene Perturbation Signatures -1.0 null GSE210662_2_v_1_znf165_human RummaGEO Gene Perturbation Signatures 1.0 null GSE182854_2_v_3_sirt1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE48812_3_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null Serine/threonine/dual specificity protein kinase, catalytic domain InterPro Predicted Protein Domain Annotations 1.0 null GSE110268_0_v_3_foxd1_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN015_MCF10A_48H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.06015 GSE147893,GSE147897_2_v_1_rbm4_human RummaGEO Gene Perturbation Signatures 1.0 null GSE110268_2_v_3_foxd1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE201309_5_v_0_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE215849_2_v_1_muc1_human RummaGEO Gene Perturbation Signatures 1.0 null Actin cytoskeleton-regulatory complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.7 GSE138050,GSE148257_1_v_2_progesterone_human RummaGEO Drug Perturbation Signatures -1.0 null Piccolo NuA4 histone acetyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.62 GSE233679_12_v_2_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:L01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9247 PMC8384902-mmc5.xlsx-H128_PROX1_ChIP-Symbol_PROX1 Rummagene Transcription Factor Associations 2026 1.0 null GSE112714_2_v_3_ctnnb1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE182179_0_v_3_kdsr_human RummaGEO Gene Perturbation Signatures 1.0 null NE-20-WM78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.932408 KLF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 216.365 Protein kinase, ATP binding site InterPro Predicted Protein Domain Annotations 1.0 null GSE213715_0_v_1_iqgap2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE211128_9_v_0_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE238018_1_v_0_mxra8_human RummaGEO Gene Perturbation Signatures 1.0 null GSE97352_1_v_2_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE233679_5_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE143944_2_v_0_ribociclib_human RummaGEO Drug Perturbation Signatures 1.0 null regulation of cell cycle GO Biological Process Annotations 2025 1.0 null PMC9882185-media-2.xlsx-All_B2-AR_targets-gene_id_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE206516,GSE206518_3_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE137325_3_v_0_copanlisib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE164529_0_v_1_tamoxifen_human RummaGEO Drug Perturbation Signatures 1.0 null GSE201309_5_v_3_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null Newly Diagnosed Childhood Ependymoma DisGeNET Gene-Disease Associations 1.0 null GSE235066_7_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_MCF10A_48H:J16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.6683 Smooth muscle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.265 KLF15 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 302.052 GSE140965_2_v_4_mybpc3_human RummaGEO Gene Perturbation Signatures 1.0 null GSE178714_6_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null CF-87-AS90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.744186 GSE233679_6_v_10_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null Preoptic area TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.394 GSE233679_5_v_3_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null Gastric adenocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.961 JD-81-YX02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.64618 GSE233679_6_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null GLIS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 67.4275 Adrenal cortex cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.82 GSE175787_13_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GSE143499_0_v_1_gata6_human RummaGEO Gene Perturbation Signatures 1.0 null FF-86-NH56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.338075 GSE193258,GSE193259_2_v_6_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null Hairy cell leukemia cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.789 GSE135030_3_v_5_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null Phyllodes Tumor DisGeNET Gene-Disease Associations 1.0 null Ltk TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.977 GSE184892_7_v_2_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null GSE217452_3_v_0_docetaxel_human RummaGEO Drug Perturbation Signatures -1.0 null GSE202434,GSE202438_6_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE209698_2_v_1_calcitriol_human RummaGEO Drug Perturbation Signatures 1.0 null GSE133764_1_v_0_chd2_human RummaGEO Gene Perturbation Signatures 1.0 null CCR4-NOT core complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.57 cAMP response element binding protein binding GO Molecular Function Annotations 2025 1.0 null GSE147876,GSE147877_2_v_10_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE176305_0_v_1_rotenone_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_MCF10A.WT.HP_24H:P14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05706 positive regulation of apoptotic process GO Biological Process Annotations 2025 1.0 null CRCGN017_MCF10A.TP53.M_24H:A14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.64099 retromer, cargo-selective complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.581 HDA1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.593 Adrenocortical cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.778 GSE235701,GSE261434_0_v_3_enasidenib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE146982_3_v_6_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null Nasopharynx TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.265 GSE206226_2_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null PMC5799303-41598_2018_19627_MOESM3_ESM.xlsx-S12_THP1_AT_pFDR_0_3-Unnamed_1_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null GSE197555_0_v_2_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null SUP-T1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.53 GSE233679_14_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE132369,GSE132371_3_v_0_cccp_human RummaGEO Drug Perturbation Signatures 1.0 null GSE201309_5_v_8_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE112365_0_v_1_sirt1_human RummaGEO Gene Perturbation Signatures 1.0 null Rlc TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.514 GSE238018_1_v_4_mxra8_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_6297_KD_CGA_SRP355115 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE203329_2_v_1_mettl5_human RummaGEO Gene Perturbation Signatures 1.0 null Ma-Mel-19 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.004 ZNF524 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 52.2861 GSE77108_8_v_2_saha_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN014_HEPG2_24H:M15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.19767 GSE193402_0_v_4_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A.WT.HP_24H:P13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.21261 GSE202434,GSE202438_8_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null DB-21-FY75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.360355 Sin3-type complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.573 GSE225869_3_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN016_MCF10A.TP53.M_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.8463 FD-20-OG99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.293823 Zona glomerulosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.676 BeWo cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.607 Ovary cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.502 GSE130956_0_v_1_icaritin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE226249_2_v_8_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null regulation of anoikis GO Biological Process Annotations 2025 1.0 null GSE149359_2_v_1_asap2_human RummaGEO Gene Perturbation Signatures 1.0 null Pinealocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.023 GSE211128_9_v_5_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE245270_1_v_0_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null GSE215086_1_v_7_batf_human RummaGEO Gene Perturbation Signatures 1.0 null Salivary Duct Carcinoma DisGeNET Gene-Disease Associations 1.0 null Epidermal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.584 GSE203060_0_v_2_kdm4c_human RummaGEO Gene Perturbation Signatures -1.0 null GSE123638,GSE123639_0_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures -1.0 null G-361 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.815 regulation of metal ion transport GO Biological Process Annotations 2025 1.0 null CRCGN017_MCF10A.WT.HP_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.71615 GSE236437_0_v_3_aldosterone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE198794_2_v_3_usp18_human RummaGEO Gene Perturbation Signatures 1.0 null MTF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.7825 GSE118816_0_v_3_myo1c_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN008_HEPG2_24H:P05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.14615 GSE231524,GSE231526_0_v_1_dusp6_human RummaGEO Gene Perturbation Signatures 1.0 null GSE134375_0_v_2_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE147876,GSE147877_4_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE71972_11_v_6_histamine_human RummaGEO Drug Perturbation Signatures -1.0 null KLF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 112.888 ZNF213 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 65.6827 Tumor Progression DisGeNET Gene-Phenotype Associations 1.0 null GSE175787_5_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null Photoreceptor connecting cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.069 GSE168797_2_v_5_cannabidiol_human RummaGEO Drug Perturbation Signatures -1.0 null GSE173201_0_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE149359_3_v_0_asap2_human RummaGEO Gene Perturbation Signatures 1.0 null Muscle Spasticity DisGeNET Gene-Phenotype Associations 1.0 null GSE242199_6_v_7_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null Nucleus preopticus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.663 CRCGN015_HEPG2_48H:H13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.0597 Perturb_8985_KD_OPA1_SRP216831 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -16.5902 HC-74-HM63_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.265591 CRCGN015_HEPG2_48H:A13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.41188 PMC8684775-CTM2-11-e640-s002.xlsx-Sheet1-Table_S3_MAF_file_of_the_CCS_samples_MAF Rummagene Transcription Factor Associations 2026 1.0 null GSE233679_14_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE143944_2_v_3_ribociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE132369,GSE132371_2_v_0_cccp_human RummaGEO Drug Perturbation Signatures 1.0 null GSE202434,GSE202438_13_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE128730_7_v_6_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_9650_KO_RNASEH2B_SRP355094 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.4732 GSE233679_12_v_4_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE135514_2_v_7_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null colo792 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.572 Childhood Glioblastoma DisGeNET Gene-Disease Associations 1.0 null GSE210682_2_v_1_methadone_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN009_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.42477 Synovitis DisGeNET Gene-Disease Associations 1.0 null Plant cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.984 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-2cell_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null CRCGN015_MCF10A_48H:P04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.1039 Viscus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 GSE153354_0_v_1_tcf19_human RummaGEO Gene Perturbation Signatures 1.0 null GSE230283_1_v_0_birc2_human RummaGEO Gene Perturbation Signatures 1.0 null Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE229671,GSE229673_3_v_1_yrdc_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN017_MCF10A.WT.HP_24H:K16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.09975 MZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.9527 SP9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 208.375 GSE234637_3_v_0_ikzf1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE126463_1_v_3_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null Arcopallium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.061 CRCGN015_MCF10A.TP53.M_24H:D17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1725 PMC9634663-DataSheet10.xlsx-K562-MYC-AID_RNA-Seq_1326_MYC Rummagene Transcription Factor Associations 2026 1.0 null EE-03-SG02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.359932 GSE239844_6_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null negative regulation of biosynthetic process GO Biological Process Annotations 2025 1.0 null CRCGN011_HEPG2_24H:I24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.27365 ED-05-LQ40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.709605 GSE193258,GSE193259_2_v_4_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE151090_2_v_1_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE130401_4_v_3_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null Plantaris muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.518 GSE121866_0_v_3_six4_human RummaGEO Gene Perturbation Signatures 1.0 null mdccmsb1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.047 GSE80537_5_v_2_adhfe1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE158458_2_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE202434,GSE202438_4_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null TBY-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.838 regulation of cell differentiation GO Biological Process Annotations 2025 1.0 null GLIS3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 63.0952 GSE121198,GSE129779_0_v_2_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null GTEx Blood 20-29 vs 70-79 GTEx Tissue-Specific Aging Signatures 1.0 3.07282 GSE190316,GSE190324_1_v_9_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE118077_7_v_8_sprr5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE233679_5_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE138863_3_v_1_disulfiram_human RummaGEO Drug Perturbation Signatures 1.0 null OF-05-CB18_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.2446 GSE244710_3_v_2_srsf1_human RummaGEO Gene Perturbation Signatures 1.0 null SKOV-3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.081 GSE135352_2_v_4_napabucasin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE202434,GSE202438_3_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE203429_0_v_1_angptl8_human RummaGEO Gene Perturbation Signatures -1.0 null GSE135350_2_v_7_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN008_HEPG2_24H:J17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0188 GTEx Thyroid 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures 1.0 8.08214 GSE171837_3_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures -1.0 null b63 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.702 GSE182179_0_v_1_kdsr_human RummaGEO Gene Perturbation Signatures 1.0 null GSE239844_8_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null ZIC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 176.421 GSE193993_1_v_3_sstr2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE145171_0_v_1_prox1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE240030,GSE252532_0_v_2_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_2_RFX1 Rummagene Transcription Factor Associations 2026 1.0 null GD-66-XE49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.213841 Nuclear pore linkers COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.688 GSE120612_7_v_0_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE74251_0_v_3_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null Kco TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.505 GSE138841_0_v_1_trim6_human RummaGEO Gene Perturbation Signatures -1.0 null GSE119978,GSE180930_3_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE243199_1_v_0_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null regulation of gluconeogenesis GO Biological Process Annotations 2025 1.0 null GSE233679_14_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE111247_0_v_1_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE206516,GSE206518_3_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE93156_1_v_0_idelalisib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE130676_0_v_2_suds3_human RummaGEO Gene Perturbation Signatures 1.0 null High vocal center TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.593 GSE242555_1_v_0_fn3k_human RummaGEO Gene Perturbation Signatures 1.0 null lm8 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.503 TFAP2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 161.977 spermathecal-uterine valve TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.808 Perturb_2881_KD_YAP1/WWTR1_SRP201886 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.1345 GSE121198,GSE129779_3_v_1_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null GSE135514_2_v_9_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE211215_1_v_0_akr1b1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE199092_1_v_0_ddx5_human RummaGEO Gene Perturbation Signatures 1.0 null Epithalamus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.134 KLF11 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 173.745 FC-85-OX77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.267973 Plant vessel TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.652 GSE178714_6_v_7_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE175787_4_v_7_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null Cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GSE233679_14_v_15_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE157894_2_v_0_cystine_human RummaGEO Drug Perturbation Signatures -1.0 null EC-9706 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.17 H-NS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.514 Prdm4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.8044 GSE111247_11_v_3_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null Myosin phosphatase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.785 OK cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.726 GSE114013,GSE114014_1_v_3_itraconazole_human RummaGEO Drug Perturbation Signatures 1.0 null membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Apical plasma membrane urothelial plaque COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.728 GSE71468,GSE76476_2_v_3_rbfox1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE160001,GSE160670_0_v_2_lapatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE213588_8_v_7_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null PB-18-HD85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.786905 GSE233679_6_v_4_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE99875_2_v_0_everolimus_human RummaGEO Drug Perturbation Signatures 1.0 null Large Cell Neuroendocrine Carcinoma DisGeNET Gene-Disease Associations 1.0 null ZBTB14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 65.4502 Exoskeleton TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.687 IC-05-WD74_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.257054 CRCGN016_MCF10A.WT.HP_24H:A21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8504 CRCGN015_MCF10A_48H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.7596 GSE182680,GSE182683_0_v_11_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null GSE158834_0_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null TFAP2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 209.131 GSE121198,GSE129779_0_v_1_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null GSE135030_11_v_4_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE219195_4_v_2_rbm12_human RummaGEO Gene Perturbation Signatures 1.0 null GSE219195_0_v_2_rbm12_human RummaGEO Gene Perturbation Signatures 1.0 null KLF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 115.782 GSE202434,GSE202438_15_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null Placenta TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.052 DYRK1A Kinase Library Serine Threonine Kinome Atlas 1.0 null Calu-6 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.579 Collecting duct cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.832 GSE233679_6_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null WB-48-EF24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.477041 TCF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.8983 GSE121198,GSE129782_1_v_0_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null GSE242083,GSE242098_2_v_0_med1_human RummaGEO Gene Perturbation Signatures -1.0 null EGR4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 189.281 Adult Glioblastoma DisGeNET Gene-Disease Associations 1.0 null GSE119345_2_v_3_bexarotene_human RummaGEO Drug Perturbation Signatures -1.0 null GSE184892_7_v_5_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null GSE115395_2_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE142210_2_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE135514_8_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null RA-27-ST16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.300362 Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_2_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null GSE198794_0_v_3_usp18_human RummaGEO Gene Perturbation Signatures 1.0 null A2780/CDDP cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.707 Osteoarthritis DisGeNET Gene-Disease Associations 1.0 null Peripheral blood TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.195 MV4-11 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.74 GSE48812_0_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null GSE233679_5_v_15_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Diastolic blood pressure GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.1 GSE149366_1_v_0_sulconazole_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_MCF10A.TP53.M_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1608 BB-87-SF89_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.29736 VEZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 93.4843 Salt gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.545 Plastron TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.512 GSE71972_9_v_12_histamine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE164874_5_v_6_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_2699_KD_EXOSC8_ERP005752 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.22513 MCM core complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.931 DB-54-GQ68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.408015 GSE132369,GSE132371_5_v_0_cccp_human RummaGEO Drug Perturbation Signatures 1.0 null GSE232714_0_v_1_raver1_human RummaGEO Gene Perturbation Signatures -1.0 null protein kinase binding GO Molecular Function Annotations 2025 1.0 null TORC2 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.509 GSE157282_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null L-type voltage-gated calcium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.659 GSE213228_1_v_3_irak2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE213228_4_v_0_irak2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE149760_0_v_5_elof1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE195559_0_v_9_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE158834_0_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GSE142588_2_v_1_cinobufagin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE115542_2_v_0_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null cardiac muscle cell differentiation GO Biological Process Annotations 2025 1.0 null ND-39-PO34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.250519 Microvillus membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.574 GSE169356_0_v_1_ivermectin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE77108_5_v_9_saha_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_HEPG2_48H:H19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.78939 GSE202434,GSE202438_2_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE207135_2_v_0_sod2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE173201_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE130246_1_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE174498,GSE174500_3_v_7_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null Metastatic Malignant Neoplasm To Brain DisGeNET Gene-Disease Associations 1.0 null Zona fasciculata TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.687 GSE146982_3_v_5_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE217552_3_v_4_fisetin_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_HEPG2_48H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.57929 GSE213410_2_v_3_calcitriol_human RummaGEO Drug Perturbation Signatures 1.0 null GSE217552_3_v_2_fisetin_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_HEPG2_48H:B11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.11905 GSE96649_1_v_2_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null Abdominal Pain DisGeNET Gene-Phenotype Associations 1.0 null GSE221577_4_v_5_pik3r1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE142210_9_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE244710_1_v_0_srsf1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE80182_2_v_1_prmt5_human RummaGEO Gene Perturbation Signatures -1.0 null GSE225901_2_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Hyphal tip COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.577 GSE201110_0_v_1_sirt4_human RummaGEO Gene Perturbation Signatures -1.0 null SP5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 115.388 GSE105173,GSE105175_1_v_0_dhx36_human RummaGEO Gene Perturbation Signatures 1.0 null GSE178714_5_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN011_HEPG2_24H:L12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.72235 CRCGN016_MCF10A.WT.HP_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.47156 Medulloblastoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.522 GTEx Blood 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures 1.0 14.7007 GSE135030_8_v_10_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE147366_1_v_4_med13_human RummaGEO Gene Perturbation Signatures -1.0 null GSE203329_0_v_1_mettl5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE202434,GSE202438_15_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE221327_1_v_2_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null EGR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 180.693 GSE191015_0_v_2_gsdmb_human RummaGEO Gene Perturbation Signatures -1.0 null GSE191021_1_v_0_nono_human RummaGEO Gene Perturbation Signatures 1.0 null PMC10769395-media-2.xlsx-S2D_EF_Repressed_genes-Ebegboni_et_al_Supplemental_Table_S2D_Increased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null GSE217552_3_v_0_fisetin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE224294_4_v_2_ngly1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE239688_2_v_1_canagliflozin_human RummaGEO Drug Perturbation Signatures -1.0 null nucleus GO Cellular Component Annotations 2025 1.0 null GSE244233_1_v_0_quercetin_human RummaGEO Drug Perturbation Signatures 1.0 null c8166 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.696 GSE205976,GSE205978_1_v_4_cep83_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.65022 Perturb_7892_KD_LAS1L_SRP321656 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE158632_2_v_4_oxyquinoline_human RummaGEO Drug Perturbation Signatures 1.0 null Cellular bud neck septin structure COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.673 GSE227592_5_v_3_adar_human RummaGEO Gene Perturbation Signatures 1.0 null GSE131649_2_v_3_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE77108_3_v_2_saha_human RummaGEO Drug Perturbation Signatures 1.0 null ZBTB7C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.854 Esophagus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.265 Spindle pole centrosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.64 GSE239844_1_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE202434,GSE202438_6_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null adenyl ribonucleotide binding GO Molecular Function Annotations 2025 1.0 null CRCGN015_HEPG2_48H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6283 GSE51684,GSE51741_2_v_4_c9orf72_human RummaGEO Gene Perturbation Signatures -1.0 null GSE142210_9_v_5_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE172146_2_v_0_mettl1_human RummaGEO Gene Perturbation Signatures -1.0 null regulation of sodium ion transport GO Biological Process Annotations 2025 1.0 null phosphorylation GO Biological Process Annotations 2025 1.0 null GSE135352_0_v_3_napabucasin_human RummaGEO Drug Perturbation Signatures 1.0 null ZBTB24 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 125.054 GSE158834_2_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE196259_2_v_0_gcm1_human RummaGEO Gene Perturbation Signatures 1.0 null regulation of striated muscle cell differentiation GO Biological Process Annotations 2025 1.0 null GSE233679_12_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null positive regulation of anoikis GO Biological Process Annotations 2025 1.0 null GSE253795_1_v_0_alkbh5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE95077_5_v_2_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null GSE174498,GSE174500_5_v_7_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null PMC7064337-elife-51373-supp2.xlsx-652_genes_up-regulated-List_of_652_genes_up-regulated_after_PHF19_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null Y-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.822 Epilepsy DisGeNET Gene-Disease Associations 1.0 null GSE149621_3_v_1_olaparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE164529_0_v_3_tamoxifen_human RummaGEO Drug Perturbation Signatures 1.0 null DF-00-BU08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.326241 GSE239688_2_v_5_canagliflozin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE77108_0_v_2_saha_human RummaGEO Drug Perturbation Signatures 1.0 null FE-82-WB22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.221697 GB-46-CK08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.869571 JE-72-KV75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.255235 Zfp809 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 37.582 GSE135352_0_v_4_napabucasin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE118077_4_v_2_sprr5_human RummaGEO Gene Perturbation Signatures -1.0 null GSE176326_1_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Connecting tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.709 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null GSE146982_3_v_5_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE111247_14_v_3_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE226355,GSE226357_3_v_4_ybx1_human RummaGEO Gene Perturbation Signatures 1.0 null DB-21-FY75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.587101 CRCGN016_MCF10A.WT.HP_24H:B22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.92086 GSE248770_0_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE195559_0_v_4_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE199092_3_v_0_ddx5_human RummaGEO Gene Perturbation Signatures -1.0 null GSE213650_0_v_1_everolimus_human RummaGEO Drug Perturbation Signatures 1.0 null ZD-18-MI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.339712 GSE233679_12_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null AB-18-YN11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.45272 GSE218098,GSE218099_1_v_0_tcf19_human RummaGEO Gene Perturbation Signatures -1.0 null Melanoma DisGeNET Gene-Disease Associations 1.0 null GSE89569_3_v_0_nr0b1_human RummaGEO Gene Perturbation Signatures 1.0 null Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SMAD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.7299 CRCGN016_MCF10A.WT.HP_24H:K19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.13754 GSE148200_4_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null MSL complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.652 NHLH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.8363 CRCGN015_MCF10A_48H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.35684 Suprachiasmatic nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.504 Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE213588_8_v_2_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE221327_1_v_0_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null GSE150055_0_v_2_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null Type II protein secretion system complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.581 GSE118490_1_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:P05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.17565 GSE206226_0_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE135030_8_v_7_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null PMC8384902-mmc5.xlsx-H128_ASCL1_ChIP-Symbol_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null GSE205913_1_v_0_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null MA-06-DJ95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.28532 GSE142210_3_v_5_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Adrenocortical carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.028 GSE133763_0_v_2_chd1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE205630_0_v_1_gmds_human RummaGEO Gene Perturbation Signatures 1.0 null GSE239844_7_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null Axonal spine COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.513 Lung TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE135514_8_v_5_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE202434,GSE202438_3_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE171845_4_v_3_ccne1_human RummaGEO Gene Perturbation Signatures 1.0 null Blood TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.195 WE-48-PP43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.485887 negative regulation of DNA-binding transcription factor activity GO Biological Process Annotations 2025 1.0 null GSE143743_0_v_2_c9orf72_human RummaGEO Gene Perturbation Signatures 1.0 null Tmm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.994 GSE213588_9_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null Hypothalamic nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.465 CE-20-VA70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.202324 TFAP2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 180.304 CRCGN017_MCF10A.TP53.M_24H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.19387 GSE227592_8_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null GSE162892_3_v_2_sox9_human RummaGEO Gene Perturbation Signatures -1.0 null GSE70935_3_v_4_cyfip1_human RummaGEO Gene Perturbation Signatures -1.0 null protein serine/threonine kinase activity GO Molecular Function Annotations 2025 1.0 null Gall bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.265 GSE233049_2_v_0_atf3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE172494_3_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE164874_5_v_3_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null KLF13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.6426 KLF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 85.5966 GSE226115,GSE226116_2_v_0_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE214685_0_v_1_nsun2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE128333_3_v_0_tcf4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE187006_3_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null photoperiodism GO Biological Process Annotations 2025 1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Vibrissa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.507 GSE233679_12_v_9_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null ZIC5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 217.289 GSE173201_2_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null pl90 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.728 Cervical squamous cell carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.307 CRCGN015_HEPG2_48H:M23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.17773 RNA-directed RNA polymerase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.844 GSE226355,GSE226357_1_v_0_ybx1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE129241_4_v_0_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN016_MCF10A.WT.HP_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.69795 Anaplasia DisGeNET Gene-Disease Associations 1.0 null GSE184892_4_v_1_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null GSE155836,GSE155839_3_v_2_alvocidib_human RummaGEO Drug Perturbation Signatures -1.0 null ZNF707 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 83.4978 Non-Small Cell Lung Carcinoma DisGeNET Gene-Disease Associations 1.0 null Glucagon signaling pathway KEGG Pathways 2026 1.0 null negative regulation of lipid biosynthetic process GO Biological Process Annotations 2025 1.0 null Ventral aorta TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.893 GSE236003_2_v_3_ubr5_human RummaGEO Gene Perturbation Signatures -1.0 null Rpd3L complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.766 GSE135352_2_v_3_napabucasin_human RummaGEO Drug Perturbation Signatures 1.0 null Nucleus preopticus medialis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.506 GSE113005_0_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null Thoracic ganglion TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.748 CRCGN011_HEPG2_24H:B03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0773 GSE149621_0_v_1_olaparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE238116_1_v_0_egr1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE248769_1_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE235066_7_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE135514_8_v_9_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE202434,GSE202438_8_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.265198 ZNF354C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6875 NR1I2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.5681 ZBTB7B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.2054 Adrenal glomerulosa cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.683 GSE48812_8_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null KLF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 203.247 GSE133763_0_v_1_chd1_human RummaGEO Gene Perturbation Signatures 1.0 null UF-27-HS98_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.832236 Adrenal gland cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.833 Protein kinase-like domain InterPro Predicted Protein Domain Annotations 1.0 null GSE149000_2_v_0_cyp3a5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE190555,GSE190557_2_v_3_chd4_human RummaGEO Gene Perturbation Signatures 1.0 null GSE238018_3_v_0_mxra8_human RummaGEO Gene Perturbation Signatures -1.0 null S0-EE-Y4UM_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.228644 GSE233679_12_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null metal ion binding GO Molecular Function Annotations 2025 1.0 null GSE190316,GSE190324_0_v_11_rbm4_human RummaGEO Gene Perturbation Signatures 1.0 null magnesium ion binding GO Molecular Function Annotations 2025 1.0 null PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-down-Gene_ID_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null GSE261563_9_v_1_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null GSE182179_2_v_4_kdsr_human RummaGEO Gene Perturbation Signatures -1.0 null GSE96544_1_v_0_mebendazole_human RummaGEO Drug Perturbation Signatures 1.0 null GSE223609,GSE223610_0_v_1_kdm6a_human RummaGEO Gene Perturbation Signatures -1.0 null regulation of triglyceride biosynthetic process GO Biological Process Annotations 2025 1.0 null GSE175787_5_v_7_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_3525_KD_NDP52_SRP345438 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 MA-10 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.989 GSE150895,GSE150896_0_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE229973_4_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE171837_3_v_2_bortezomib_human RummaGEO Drug Perturbation Signatures -1.0 null Malignant Neoplasm DisGeNET Gene-Disease Associations 1.0 null GSE182179_5_v_4_kdsr_human RummaGEO Gene Perturbation Signatures -1.0 null BC-10-SB73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.321187 Red vs. brown/black hair color GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.8 GSE211128_3_v_5_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null AA-32-DP01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.410941 GSE135030_11_v_1_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE193993_0_v_3_sstr2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE200839,GSE233826_3_v_4_tnrc18_human RummaGEO Gene Perturbation Signatures 1.0 null GSE168797_1_v_6_cannabidiol_human RummaGEO Drug Perturbation Signatures -1.0 null HC-92-HE59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.693177 Gluteal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.641 GSE245270_1_v_4_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null GSE77108_6_v_2_saha_human RummaGEO Drug Perturbation Signatures 1.0 null UMR-106 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.584 GSE157296,GSE157298_4_v_3_kbtbd4_human RummaGEO Gene Perturbation Signatures -1.0 null Developmental and epileptic encephalopathy ClinVar Gene-Phenotype Associations 2025 1.0 null CRCGN015_MCF10A_48H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.88705 Stria terminalis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.792 GSE183606_1_v_0_rutaecarpine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE255410,GSE255416_1_v_0_foxo1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE131649_2_v_9_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_14626_KO_OGT_SRP146064 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.4307 GSE217452_2_v_0_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_HEPG2_48H:A14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.88575 CRCGN015_HEPG2_48H:B22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.03674 Perturb_14089_KO_SMARCA2_SRP295674 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE214212_2_v_0_chd6_human RummaGEO Gene Perturbation Signatures 1.0 null GSE138863_2_v_1_disulfiram_human RummaGEO Drug Perturbation Signatures 1.0 null GSE98898_8_v_1_hoxa1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE238018_3_v_5_mxra8_human RummaGEO Gene Perturbation Signatures -1.0 null ZNF682 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 100.943 MAZ JASPAR Predicted Human Transcription Factor Targets 2025 1.0 121.575 GSE133329_0_v_3_trim28_human RummaGEO Gene Perturbation Signatures 1.0 null GSE215086_5_v_7_batf_human RummaGEO Gene Perturbation Signatures 1.0 null GSE199204,GSE211619_4_v_3_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null Bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.265 GSE133764_2_v_0_chd2_human RummaGEO Gene Perturbation Signatures 1.0 null Anterior visceral endoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.52 GSE213588_8_v_6_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE171837_0_v_2_bortezomib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE225869_2_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE146982_3_v_6_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null h4tg TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.348 Oil gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.939 GSE77108_0_v_7_saha_human RummaGEO Drug Perturbation Signatures -1.0 null GSE213588_10_v_7_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE147876,GSE147877_2_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE236504,GSE236505_0_v_1_atmin_human RummaGEO Gene Perturbation Signatures 1.0 null Protein kinase domain InterPro Predicted Protein Domain Annotations 1.0 null Organism form TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.052 PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_left-x_TFEB_KO_con_VS_WT_con_DOWN_TFEB Rummagene Transcription Factor Associations 2026 1.0 null ZNF669 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.76 Epitrochlearis muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.678 GSE233679_12_v_11_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null Mpp10 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.701 GSE158834_10_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GSE208350_4_v_1_fgfr1_human RummaGEO Gene Perturbation Signatures -1.0 null ZBTB6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.9555 ZBED4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 329.32 GSE202434,GSE202438_6_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE158182_3_v_0_pnpla3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE196962_2_v_1_parg_human RummaGEO Gene Perturbation Signatures -1.0 null GSE152441,GSE152442_7_v_3_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE211128_7_v_6_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null Box C/D RNP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.563 GSE161825_1_v_0_tipranavir_human RummaGEO Drug Perturbation Signatures -1.0 null Leukemia DisGeNET Gene-Disease Associations 1.0 null GSE147876,GSE147877_2_v_6_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE233679_5_v_8_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null Rheumatoid Arthritis DisGeNET Gene-Disease Associations 1.0 null GSE102870_3_v_0_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE135514_2_v_6_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE126463_5_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null ZNF454 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 208.649 GSE175787_11_v_6_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null DD-75-HY40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.304814 AA-11-RO46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.275893 GSE219274,GSE219276_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null Serine/threonine-protein kinase, SIK1/2 InterPro Predicted Protein Domain Annotations 1.0 null GSE87617_1_v_0_ascl1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE135030_8_v_5_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null GF-35-IT27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.559796 GSE200839,GSE233826_3_v_6_tnrc18_human RummaGEO Gene Perturbation Signatures -1.0 null GSE158182_3_v_7_pnpla3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE119978,GSE180930_2_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE199204,GSE211619_4_v_7_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_6296_KD_NIPBL_SRP221332 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 18.9586 GSE95077_5_v_4_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null col10 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.559 AB-64-ZX70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.233511 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null Transcription factor TFIID complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.719 496100318_PCx_probable Alzheimer's disease_TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.4431 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE233679_14_v_9_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_MCF10A.WT.HP_24H:L01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.95782 GSE78199_0_v_3_tamoxifen_human RummaGEO Drug Perturbation Signatures 1.0 null karpas45 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.981 LC-12-VN85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.297833 GSE146982_4_v_5_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE158438_4_v_12_lenalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE216043_10_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Preosteoclast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.539 DC-51-WE27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.284152 PMC11390959-41598_2024_70075_MOESM3_ESM.xlsx-520_DMD_common_down_gene_list-HES4_HES4 Rummagene Transcription Factor Associations 2026 1.0 null GSE190761_0_v_1_samd1_human RummaGEO Gene Perturbation Signatures -1.0 null Adrenal gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.777 MYOD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.9213 DA-35-DU85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.263169 EGR2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 144.594 GSE186471_1_v_0_carnosol_human RummaGEO Drug Perturbation Signatures 1.0 null negative regulation of triglyceride biosynthetic process GO Biological Process Annotations 2025 1.0 null GSE190316,GSE190324_6_v_9_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null Cellular bud neck septin ring COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.673 CRCGN017_MCF10A.WT.HP_24H:E01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2519 GSE164529_0_v_2_tamoxifen_human RummaGEO Drug Perturbation Signatures 1.0 null Mpk TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.886 Shu complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.542 GSE239844_4_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE146982_4_v_1_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null Epididymal white adipose tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.591 GSE239844_1_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null Gli1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.7394 Septin cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.524 GSE126463_1_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null Akd TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.68 Cleavage apparatus septin structure COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.673 GSE114013,GSE114014_1_v_4_itraconazole_human RummaGEO Drug Perturbation Signatures 1.0 null GSE239844_1_v_5_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE151612_0_v_2_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE174498,GSE174500_0_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null TCFL5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.072 GSE245270_1_v_5_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null GSE191110_0_v_1_dnajc12_human RummaGEO Gene Perturbation Signatures 1.0 null GSE235701,GSE261434_2_v_3_enasidenib_human RummaGEO Drug Perturbation Signatures -1.0 null EC-62-OE64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.423958 GSE102467_3_v_0_pazopanib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE205332_1_v_0_queuine_human RummaGEO Drug Perturbation Signatures 1.0 null CC-61-HH09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.407828 Organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_id_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE159893_2_v_0_genistein_human RummaGEO Drug Perturbation Signatures -1.0 null Zfp961 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 36.9697 GSE164874_5_v_10_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null Ependymoma DisGeNET Gene-Disease Associations 1.0 null GSE128730_3_v_5_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote InterPro Predicted Protein Domain Annotations 1.0 null GSE150895,GSE150896_0_v_1_kif15_human RummaGEO Gene Perturbation Signatures -1.0 null GSE217552_3_v_5_fisetin_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H510 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.718 Perturb_9187_OE_NeuroD4_SRP390425 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE228261_0_v_1_elesclomol_human RummaGEO Drug Perturbation Signatures -1.0 null PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Supplementary_Table_4B_DEGs_in_ATF4-def_cells_comparing_Tg_2h_to_its_DMSO_control_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null MYCN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.616 GID complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.646 Viral RNA-directed RNA polymerase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.905 REST JASPAR Predicted Human Transcription Factor Targets 2025 1.0 61.6212 Blond vs. brown/black hair color GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.4699 GSE110580_1_v_0_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE111881_0_v_1_znf768_human RummaGEO Gene Perturbation Signatures 1.0 null LLC-RK1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.853 GSE210101,GSE210114_7_v_3_urod_human RummaGEO Gene Perturbation Signatures 1.0 null Nucleus preopticus medianus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.526 Aortic adventitial fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE192771_2_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.432626 GSE200839,GSE233826_5_v_6_tnrc18_human RummaGEO Gene Perturbation Signatures -1.0 null Lymphoid tissue TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Carcinogenesis DisGeNET Gene-Phenotype Associations 1.0 null JC-06-ED36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.445593 GSE210388_2_v_0_ror2_human RummaGEO Gene Perturbation Signatures 1.0 null Cell tip COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.811 GSE202434,GSE202438_10_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE134896_0_v_7_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE153867_6_v_3_olaparib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE166920_6_v_3_adalimumab_human RummaGEO Drug Perturbation Signatures 1.0 null DD-36-YH76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.834107 Host extracellular space COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.51 GSE184892_6_v_1_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null ZNF549 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 80.2018 GE-53-SM76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.593297 CRCGN014_HEPG2_3H:D02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.49561 BC-25-VR48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.538022 GSE154197_1_v_2_ints13_human RummaGEO Gene Perturbation Signatures -1.0 null GSE48812_8_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN016_MCF10A.WT.HP_24H:A22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.22033 entrainment of circadian clock by photoperiod GO Biological Process Annotations 2025 1.0 null BB-87-SF89_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.30883 GSE211215_1_v_0_pemetrexed_human RummaGEO Drug Perturbation Signatures -1.0 null GSE146982_4_v_5_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE169205_3_v_6_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF93 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 118.09 CRCGN015_MCF10A_48H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.51355 GSE202434,GSE202438_12_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE77108_5_v_2_saha_human RummaGEO Drug Perturbation Signatures 1.0 null GSE199204,GSE211619_4_v_5_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null UF-06-JB00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.296312 GSE216043_7_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE146982_3_v_1_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE205730,GSE205731_2_v_0_tazemetostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE68925_1_v_0_fasudil_human RummaGEO Drug Perturbation Signatures 1.0 null HF-91-IU60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.782173 wc1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.606 CRCGN016_MCF10A.WT.HP_24H:M05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.09021 NMuMg cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.796 GSE203181_0_v_1_phosphoramidon_human RummaGEO Drug Perturbation Signatures -1.0 null GSE135514_2_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null kinase binding GO Molecular Function Annotations 2025 1.0 null GSE140651,GSE140653_2_v_1_med1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE48812_9_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null GSE202434,GSE202438_4_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null Vastus medialis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.769 GSE218060_7_v_4_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE225982_1_v_0_ezetimibe_human RummaGEO Drug Perturbation Signatures 1.0 null GSE135030_8_v_2_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE157894_2_v_3_cystine_human RummaGEO Drug Perturbation Signatures -1.0 null PMC8948659-ADVS-9-2104491-s013.xlsx-Sheet1-Supplemental_Table_9_related_to_Figure_7_Differential_genes_highly_correlated_with_TP53_deletion_in_H929_cells_by_RNA-seq_TP53 Rummagene Transcription Factor Associations 2026 1.0 null GSE158834_0_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GSE123105,GSE124556_0_v_2_pcf11_human RummaGEO Gene Perturbation Signatures -1.0 null HINFP JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.7493 Adult Ependymoma DisGeNET Gene-Disease Associations 1.0 null GSE190076_0_v_1_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null Allergic disease (asthma, hay fever or eczema) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.8 Intimal Sarcoma DisGeNET Gene-Disease Associations 1.0 null GSE125014_1_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Pain DisGeNET Gene-Phenotype Associations 1.0 null Wart TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.942 GSE242521,GSE242522_0_v_1_mettl3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE219274,GSE219276_2_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null a238 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.02 GSE190316,GSE190324_1_v_11_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null Immune system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE249098_3_v_2_mthfd1l_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN010_HEPG2_24H:I02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.04457 GSE205729,GSE205731_2_v_1_tazemetostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE111247_11_v_9_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE233679_14_v_8_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null AC-50-FR41_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.211559 MYOG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.1411 GSE175787_4_v_6_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null GSE211474,GSE212779_0_v_1_phf8_human RummaGEO Gene Perturbation Signatures -1.0 null Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE254649_3_v_1_cstf2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE200839,GSE233826_2_v_4_tnrc18_human RummaGEO Gene Perturbation Signatures 1.0 null GSE213228_1_v_5_irak2_human RummaGEO Gene Perturbation Signatures -1.0 null ZNF740 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 327.972 oc316 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.025 negative regulation of triglyceride metabolic process GO Biological Process Annotations 2025 1.0 null ZNF135 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 51.3101 GSE242199_6_v_0_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE146982_3_v_1_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null Tfcp2l1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 51.6852 Coughing DisGeNET Gene-Phenotype Associations 1.0 null Adrenal cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.633 GSE118816_2_v_3_myo1c_human RummaGEO Gene Perturbation Signatures 1.0 null GLIS2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 140.13 GSE148262,GSE150691_1_v_0_hdlbp_human RummaGEO Gene Perturbation Signatures -1.0 null KLF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 290.462 AA-23-FM46_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.317974 F5 meningioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.831 CRCGN011_HEPG2_24H:H04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.178 CRCGN015_HEPG2_48H:L20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.93642 Gin4 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.673 GSE89057_0_v_1_sox5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE225869_2_v_0_cd44_human RummaGEO Gene Perturbation Signatures -1.0 null GSE195503_3_v_2_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE128730_4_v_6_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null HEY cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.83 CRCGN015_MCF10A_48H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.45268 KLF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 239.084 Perturb_3687_KD_RARRES2_SRP287866 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.49129 GSE158458_2_v_3_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE213588_9_v_11_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN017_MCF10A.TP53.M_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.23848 GSE147876,GSE147877_4_v_6_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE134615_1_v_0_lats1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE135030_11_v_6_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE140651,GSE140653_3_v_7_med1_human RummaGEO Gene Perturbation Signatures -1.0 null MPT synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.107 GSE200839,GSE233826_3_v_0_tnrc18_human RummaGEO Gene Perturbation Signatures 1.0 null Intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GSE211128_4_v_6_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null DA-35-DU85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.358611 GSE149035_1_v_5_hepacam_human RummaGEO Gene Perturbation Signatures -1.0 null GSE200839,GSE233826_2_v_6_tnrc18_human RummaGEO Gene Perturbation Signatures -1.0 null GSE238018_3_v_2_mxra8_human RummaGEO Gene Perturbation Signatures -1.0 null FB-39-CW59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.770217 GSE213588_10_v_6_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_1_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null GSE225901_2_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF148 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 345.901 GSE132369,GSE132371_1_v_0_cccp_human RummaGEO Drug Perturbation Signatures 1.0 null Spinal cord TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.462 RREB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 191.364 GSE233679_6_v_13_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE233679_6_v_2_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null BA-56-QV45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.377805 GSE77108_0_v_9_saha_human RummaGEO Drug Perturbation Signatures -1.0 null GSE175787_5_v_10_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null Osteocyte cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.514 Serine/threonine-protein kinase, active site InterPro Predicted Protein Domain Annotations 1.0 null GSE234637_3_v_0_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE244710_1_v_2_srsf1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE154350_1_v_0_ascl2_human RummaGEO Gene Perturbation Signatures -1.0 null Pharynx TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.265 Leukoplakia DisGeNET Gene-Disease Associations 1.0 null GSE211128_2_v_1_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null GSE166184,GSE166185_1_v_0_sox2_human RummaGEO Gene Perturbation Signatures -1.0 null ZE-45-CG69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.825926 GSE154197_1_v_0_ints13_human RummaGEO Gene Perturbation Signatures -1.0 null GSE94849_3_v_2_pinometostat_human RummaGEO Drug Perturbation Signatures -1.0 null GSE146982_4_v_6_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE239844_1_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null Cell envelope Sec protein transport complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.544 cardiac muscle tissue development GO Biological Process Annotations 2025 1.0 null GSE120612_7_v_1_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null PLAGL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 113.322 ZNF460 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 234.391 GSE128730_4_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE202434,GSE202438_12_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE48812_11_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GSE210101,GSE210114_4_v_3_urod_human RummaGEO Gene Perturbation Signatures 1.0 null GSE239844_11_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null Nidopallium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.55 GSE193351_1_v_0_ruxolitinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE250089_0_v_3_epcam_human RummaGEO Gene Perturbation Signatures 1.0 null GSE221633_0_v_1_trim24_human RummaGEO Gene Perturbation Signatures 1.0 null GSE233679_14_v_13_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE96649_1_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE186471_1_v_2_carnosol_human RummaGEO Drug Perturbation Signatures 1.0 null PMC5799303-41598_2018_19627_MOESM3_ESM.xlsx-S12_THP1_AT_pFDR_0_3-Unnamed_2_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null GSE48812_3_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null NHLH2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 100.456 GSE128730_7_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE225901_0_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null GSE192771_2_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE135350_3_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE202434,GSE202438_15_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE214382,GSE214383_0_v_2_ascl1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE195503_3_v_0_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null ll29 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.58 GSE175787_4_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null Gli2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.5405 GSE249404_0_v_1_oxytocin_human RummaGEO Drug Perturbation Signatures 1.0 null DNA-binding transcription factor binding GO Molecular Function Annotations 2025 1.0 null GSE163297_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_MCF10A.TP53.M_24H:A24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3383 Wnt signalosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.58 DC-51-WE27_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.542858 GSE182185_0_v_1_pstk_human RummaGEO Gene Perturbation Signatures -1.0 null GSE119978,GSE180930_0_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null protein modification process GO Biological Process Annotations 2025 1.0 null GSE219195_0_v_5_rbm12_human RummaGEO Gene Perturbation Signatures -1.0 null mBAF complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.512 GSE175787_4_v_2_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null protein autophosphorylation GO Biological Process Annotations 2025 1.0 null GSE210911_1_v_0_crem_human RummaGEO Gene Perturbation Signatures -1.0 null NF-21-HQ00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.602168 GSE135514_2_v_5_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE202434,GSE202438_6_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE202434,GSE202438_15_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.313279 EF-74-KW12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.230031 Hic1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.7798 GSE206784_3_v_4_ninl_human RummaGEO Gene Perturbation Signatures -1.0 null GSE149621_2_v_1_olaparib_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN013_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.54158 negative regulation of CREB transcription factor activity GO Biological Process Annotations 2025 1.0 null GSE207514,GSE207515_1_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures 1.0 null Pineal gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.998 HEY1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0009 ZNF701 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 62.053 GSE233679_14_v_3_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN017_MCF10A.WT.HP_24H:A14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35835 GSE171837_0_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE168797_2_v_0_cannabidiol_human RummaGEO Drug Perturbation Signatures -1.0 null GSE213588_10_v_3_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE202434,GSE202438_7_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H1944 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.53 Cysteine synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.549 GSE149760_0_v_1_elof1_human RummaGEO Gene Perturbation Signatures 1.0 null Rab-protein geranylgeranyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.609 CRCGN016_MCF10A.WT.HP_24H:F14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.70074 Pupal wing TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.649 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE135030_11_v_9_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.5399 Early Myoclonic Encephalopathy DisGeNET Gene-Disease Associations 1.0 null Liver cancer stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.645 Glioblastoma DisGeNET Gene-Disease Associations 1.0 null GSE233679_5_v_9_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE202434,GSE202438_9_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null B-lymphoblastoid cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.97 Degenerative Polyarthritis DisGeNET Gene-Disease Associations 1.0 null Activin AB complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.528 GSE135514_8_v_7_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null Respiratory system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_2_CTCF Rummagene Transcription Factor Associations 2026 1.0 null GSE126776_0_v_1_pelp1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE249098_1_v_0_mthfd1l_human RummaGEO Gene Perturbation Signatures 1.0 null GSE193258,GSE193259_2_v_3_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE128563_2_v_6_venetoclax_human RummaGEO Drug Perturbation Signatures 1.0 null JA-85-SW39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.249368 Sporophyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.542 GSE201309_1_v_3_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE121866_1_v_3_six4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE225869_3_v_0_cd44_human RummaGEO Gene Perturbation Signatures -1.0 null Renal proximal tubule cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.959 GSE135350_2_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE134029_3_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE126463_6_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE236437_2_v_3_aldosterone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE168473_0_v_1_isoniazid_human RummaGEO Drug Perturbation Signatures -1.0 null GSE236003_1_v_3_ubr5_human RummaGEO Gene Perturbation Signatures -1.0 null GSE162892_3_v_2_isox_human RummaGEO Drug Perturbation Signatures -1.0 null Ekl TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.908 GSE178714_5_v_7_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE242199_9_v_7_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null FE-10-KQ78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.399523 GSE233049_1_v_3_atf3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE184892_4_v_5_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null GSE229973_3_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE218727_0_v_1_zkscan3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE161800_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null SAS acetyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.716 SNAI2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.014 GSE195503_1_v_2_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null H4 histone acetyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.83 GSE233679_12_v_13_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null Oc cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.934 GSE188721_3_v_4_mesp1_human RummaGEO Gene Perturbation Signatures 1.0 null E2F8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.6142 GSE235550_1_v_0_hspa9_human RummaGEO Gene Perturbation Signatures 1.0 null ZEB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.2368 PD-70-VS77_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.243311 GSE210101,GSE210114_8_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN011_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.0877 Perturb_14712_KD_TBX3_SRP305624 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.01686 Intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GSE202434,GSE202438_3_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_8044_KD_GIPC_SRP264915 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 9.48391 GSE213588_10_v_2_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE184892_4_v_2_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null GSE218727_2_v_1_zkscan3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE213650_3_v_1_everolimus_human RummaGEO Drug Perturbation Signatures 1.0 null GSE119978,GSE180930_6_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE128730_4_v_5_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE164874_5_v_13_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_13728_KD_KRAS_SRP116072 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE128333_2_v_1_tcf4_human RummaGEO Gene Perturbation Signatures 1.0 null PMC6525352-12859_2019_2805_MOESM4_ESM.xlsx-BRM_ZF_Human_integration-gene_id_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null GSE128730_0_v_1_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null CE-18-AP15_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.235224 GSE196259_1_v_3_gcm1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE193402_0_v_2_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null EGR3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 197.67 Gonad TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 TCF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.1056 GSE89729_0_v_1_ppard_human RummaGEO Gene Perturbation Signatures -1.0 null GSE135030_3_v_1_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null PMC6525352-12859_2019_2805_MOESM4_ESM.xlsx-BRM_ZF_Human_integration-Tracking_ID_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null GSE135030_8_v_0_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE186280_1_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null ASCL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 77.9265 negative regulation of small molecule metabolic process GO Biological Process Annotations 2025 1.0 null GSE158834_0_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Nrf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 81.7893 Neural arch TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.606 Ebf4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.5467 GSE145790_0_v_1_bruceantin_human RummaGEO Drug Perturbation Signatures 1.0 null AA-58-FJ71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.404273 Cytoproct COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.645 PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_id_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE165548_2_v_13_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE146982_4_v_6_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE130956_0_v_3_icaritin_human RummaGEO Drug Perturbation Signatures 1.0 null Perinuclear region of cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.558 GSE153867_6_v_8_olaparib_human RummaGEO Drug Perturbation Signatures -1.0 null f2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.714 Dendritic cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.195 GSE233679_5_v_13_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null Systolic blood pressure GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.35229 cardiocyte differentiation GO Biological Process Annotations 2025 1.0 null GSE220942_2_v_1_galnt7_human RummaGEO Gene Perturbation Signatures -1.0 null GSE242199_9_v_0_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN017_MCF10A.WT.HP_24H:A23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.41395 GSE245270_2_v_3_isoproterenol_human RummaGEO Drug Perturbation Signatures 1.0 null GD-79-TW34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.242407 GSE158834_10_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Chiasma COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.512 Perturb_253_KD_USP18_SRP364866 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 UF-27-HS98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.971113 GSE239688_4_v_1_canagliflozin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE98898_7_v_2_hoxa1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE158834_2_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null PMC8872993-41380_2021_1274_MOESM4_ESM.xlsx-Table_S6-Supplementary_Table_S6_Differentially-Expressed_Genes_after_T-3_KD_in_hiPSC-derived_Astrocytes_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE123861_1_v_0_sin3a_human RummaGEO Gene Perturbation Signatures 1.0 null GSE128730_0_v_5_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE228430_1_v_3_fabp5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE128333_3_v_5_tcf4_human RummaGEO Gene Perturbation Signatures -1.0 null voltage-gated sodium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.872 GSE178714_1_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE168918_1_v_0_tmprss4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE178714_1_v_7_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null Set3 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.768 GSE169590_0_v_1_rptor_human RummaGEO Gene Perturbation Signatures -1.0 null GSE236003_0_v_3_ubr5_human RummaGEO Gene Perturbation Signatures -1.0 null GSE172016_2_v_5_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null GSE157036,GSE166411_3_v_1_halofuginone_human RummaGEO Drug Perturbation Signatures 1.0 null Df TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.541 CRCGN017_MCF10A.TP53.M_24H:E08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7855 EC-62-OE64_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.342906 DNA replication factor C complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.873 GSE134896_0_v_3_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null Robust nucleus of arcopallium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.238 Alzheimer disease and age of onset GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.61549 GSE199204,GSE211619_4_v_0_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE164874_5_v_9_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null GSE48812_4_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GSE48812_11_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GSE227698_2_v_4_g0s2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE234043_0_v_1_abcb1_human RummaGEO Gene Perturbation Signatures 1.0 null HB-06-WU12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.57127 GSE142210_9_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Epididymis TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.265 GSE238116_3_v_2_egr1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE218949_0_v_1_cep20_human RummaGEO Gene Perturbation Signatures 1.0 null GSE202434,GSE202438_3_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE193993_5_v_3_sstr2_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF610 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 201.187 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN Rummagene Transcription Factor Associations 2026 1.0 null 7SK snRNP COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.583 CRCGN015_MCF10A.TP53.M_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.13432 GSE207787_1_v_2_pdha1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE116930,GSE116935_1_v_6_hes7_human RummaGEO Gene Perturbation Signatures -1.0 null GSE245778_1_v_0_runx1_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN016_MCF10A.WT.HP_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.18849 Mo-B cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.819 WC-16-IR43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.282879 Testis TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Colorectal Carcinoma DisGeNET Gene-Disease Associations 1.0 null GSE264010_0_v_1_parp1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE217526_0_v_1_parthenolide_human RummaGEO Drug Perturbation Signatures -1.0 null sno(s)RNA-containing ribonucleoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.885 Calcineurin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.477 GSE197555_1_v_3_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE135514_8_v_6_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null mpkCCD cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.175 PWR-1E cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.619 496100412_FWM_possible Alzheimer's disease_TBI_87_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.04225 Lumbar spine TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.79 LC-12-VN85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.27523 GSE147283_1_v_3_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null protein phosphorylation GO Biological Process Annotations 2025 1.0 null Vagina TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.265 GSE233679_12_v_10_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE112962,GSE112963_2_v_1_ddx5_human RummaGEO Gene Perturbation Signatures -1.0 null GSE211267_1_v_0_trim21_human RummaGEO Gene Perturbation Signatures 1.0 null NCI-H358 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.664 Ribonuclease MRP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.549 KF-18-RY71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.278072 GSE242333_0_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE186460_0_v_2_baricitinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE192771_2_v_1_mt1g_human RummaGEO Gene Perturbation Signatures 1.0 null GSE174498,GSE174500_5_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null GSE239844_11_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null Renal tubule epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.647 GSE182854_2_v_0_sirt1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE235516_0_v_1_zdhhc2_human RummaGEO Gene Perturbation Signatures 1.0 null Rectum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.265 GSE235550_2_v_0_hspa9_human RummaGEO Gene Perturbation Signatures 1.0 null GSE196259_2_v_3_gcm1_human RummaGEO Gene Perturbation Signatures 1.0 null Slow twitch muscle fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.607 GSE134375_3_v_7_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null GLI3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.9901 PMC6187090-mmc1.xlsx-TP53_positive-Symbol_TP53 Rummagene Transcription Factor Associations 2026 1.0 null Intracellular anatomical structure COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GSE193993_4_v_7_sstr2_human RummaGEO Gene Perturbation Signatures -1.0 null intracellular membrane-bounded organelle GO Cellular Component Annotations 2025 1.0 null S0-EE-X7LX_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.206751 GSE182179_2_v_3_kdsr_human RummaGEO Gene Perturbation Signatures -1.0 null GSE183113_1_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null Mitotic checkpoint complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.661 Osteocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.203 KLF17 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 106.015 GSE233679_6_v_11_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE48812_8_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GSE128333_4_v_1_tcf4_human RummaGEO Gene Perturbation Signatures 1.0 null GSE114013,GSE114014_0_v_4_itraconazole_human RummaGEO Drug Perturbation Signatures 1.0 null GSE222758_0_v_1_clofazimine_human RummaGEO Drug Perturbation Signatures 1.0 null Pheochromocytoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.835 BD-61-OO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.419824 NR4A2::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.5837 histamine-gated chloride channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.532 GSE219195_1_v_3_rbm12_human RummaGEO Gene Perturbation Signatures 1.0 null GSE154936_3_v_2_remdesivir_human RummaGEO Drug Perturbation Signatures 1.0 null Uterine cervix TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.265 GSE222598_1_v_0_sf3b4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE206516,GSE206518_5_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null IC-05-AW29_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.202511 CRCGN017_MCF10A.WT.HP_24H:I16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.05655 33B cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.564 GSE95386_0_v_1_trim24_human RummaGEO Gene Perturbation Signatures 1.0 null GSE48812_4_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GSE174498,GSE174500_0_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null negative regulation of carbohydrate metabolic process GO Biological Process Annotations 2025 1.0 null GSE202434,GSE202438_4_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null Childhood Ependymoma DisGeNET Gene-Disease Associations 1.0 null ZIC1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 111.012 496100391_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.42875 Liver Carcinoma DisGeNET Gene-Disease Associations 1.0 null CRCGN008_HEPG2_24H:P02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.08255 Perturb_7744_KD_HNRNPC_ERP001458 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 16.9784 GSE169205_0_v_5_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE77108_4_v_2_saha_human RummaGEO Drug Perturbation Signatures 1.0 null PR cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.51 GSE214183_1_v_0_phf8_human RummaGEO Gene Perturbation Signatures 1.0 null AC-30-XU83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.282734 GSE135030_3_v_2_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null SK-MEL-28 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.664 Photoreceptor distal connecting cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.097 GSE156454_0_v_1_tamoxifen_human RummaGEO Drug Perturbation Signatures 1.0 null DB-54-GQ68_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.491011 Perinuclear endoplasmic reticulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.601 GSE111247_2_v_7_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null Rhabdomere COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.637 GSE48812_4_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GSE219274,GSE219276_3_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN011_HEPG2_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1937 GSE245270_1_v_3_isoproterenol_human RummaGEO Drug Perturbation Signatures 1.0 null BD-04-NG34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.399509 Neoplasm Metastasis DisGeNET Gene-Phenotype Associations 1.0 null GSE240809_0_v_1_hnrnpa2b1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE233183,GSE233187_2_v_9_larp1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE195503_1_v_0_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null Neuronal dense core vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.558 GSE126776_2_v_1_pelp1_human RummaGEO Gene Perturbation Signatures 1.0 null ATP binding GO Molecular Function Annotations 2025 1.0 null GSE233679_5_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE164874_5_v_11_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null SP3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 228.798 Cellular bud COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.543 GSE142994_0_v_1_ellagic acid_human RummaGEO Drug Perturbation Signatures -1.0 null