association dataset threshold value standardized value BRD-K21124684 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46194 CSNK1G3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00556288 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K70712801 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33002 TestisLeydigCell BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.875237 Viral cardiomyopathy_Myocardial tissue_GSE4172 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.35856 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.69985 octreotide LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20789 BRD-K11310449 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31944 H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner CP in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03234 BRD-K44548010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.92935 MAP4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00790995 BRD-K92524823 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33466 BRD-K02708799_GSK-1059615_MCF7_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null METAP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00381687 MCAM LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00638421 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K67141726 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70167 CREBBP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00500206 ITGAE LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00323814 BRD-K11573765 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.50632 BRD-A19500257_geldanamycin_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NID1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00626992 HSD3B2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00605482 BRD-K56253099 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49827 H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PLPBP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00569052 NCI-H1666 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.920046 NCIH1869 CCLE Cell Line Gene CNV Profiles -1.0 -1.38956 H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null CCR2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00525426 BRD-K43389675_DAUNORUBICIN_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KMS-21BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.34586 BRD-K19103068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57001 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30963 H3K4me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 537 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29109 SLC25A2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00535063 BRD-K26376097 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57136 BRD-U61997977_WZ-4-145_HME1_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.889492 BRD-K15380626 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83359 BRD-K94088431 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19283 NCI-H2810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.969089 EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.29055 ventral tegmental area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.888726 BRD-K70154746 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22556 BRD-K99221119 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23059 BRD-K02630367 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29948 GLO1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0079525 H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Alzheimer's Disease_Entorhinal cortex_GSE5281 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.70154 BRD-K75234292 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79103 H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K07706477 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21385 H3K4me1_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null DLAT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00685994 MDH2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00432812 H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.87328 RERFLCKJ CCLE Cell Line Gene CNV Profiles -1.0 -1.51223 H3K4me3_Adipose Nuclei Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TC-71 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24056 BRD-K96239538 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.20349 outer CP in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.99415 BRD-K64728664 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45404 NFKB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0121725 CAPAN-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.012 BRD-A18328003_GDC-0980_MDAMB231_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null WT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00464466 BRD-K55392659 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19925 H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K73474555 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40051 ALDH18A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00462035 TRIM27 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.004507 HMCN2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00876426 paracentral lobule, posterior part, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18058 BRD-K96623405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72271 H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GRK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00745776 substantia nigra, compact part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.48557 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K45519638 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.15326 BRD-K30288714 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5205 BRD-K49865102_PD-0325901_HS578T_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K97255584 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38242 BRD-K23327891 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21926 NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67796 KPNA7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00550072 COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09396 L3MBTL3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00660397 SPIRE2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0076055 GTL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.876965 BRD-K71485313 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03836 FFAR3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0057547 SCLY LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00572229 PA-TU-8988S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.012 H3K4me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CHEK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00455601 BRD-A37105798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73922 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K88573743_A443654_HCC515_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ADCK5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00532973 fulvestrant_homo sapiens_gpl570_gse22533 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CDK18 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00611784 H3K4me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K85656316 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42135 H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.74645 decitabine_homo sapiens_gpl570_gse30985 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null COX7C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00672574 caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.43899 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K20160406 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02869 BRD-K67011787 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09402 H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07862 BRD-K07464613 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80296 BRD-K89338967 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21865 BRD-K51175229 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10938 BRD-K79561909 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23441 AMIGO1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00559756 H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null inner CP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.894612 BRD-A36630025_-666_CORL23_6.0_h_0.35_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA2 ENCODE Transcription Factor Targets 1.0 null BRD-A14878925 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14481 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RUNX3 ENCODE Transcription Factor Targets 1.0 null SHPK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00720396 BRD-K66909712 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07626 KCNK4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00663878 medial geniculate complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.27708 PRXL2B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00561679 LCP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00543079 H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K22797212 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.09257 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K21662756 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45806 HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.26023 BRD-K67131822 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08646 H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2018 BRD-A94366206 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5072 CMTM2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0051468 H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NTRK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00500155 H3K4me3_CD19 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null DYRK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00584452 BRD-K68463857 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29089 BT474 CCLE Cell Line Gene CNV Profiles 1.0 1.87319 NRBP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0080042 BRD-K69093885 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.35544 RT4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01328 GAS2L3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00447435 RPS6KA6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00507598 KHK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00639357 IZ in midcingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.889051 BRD-K46994278 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.12023 BRD-K04395157 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14822 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null G59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17086 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null H3K27me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K86491317 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45045 NCIH1395 CCLE Cell Line Gene CNV Profiles 1.0 1.36843 NFKB1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00646138 preoptic region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.905909 QPCT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00725191 BRD-K73874262 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85125 BRD-K42367391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39017 BRD-K01278504 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20151 CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K75007044 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01041 KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.876965 BRD-K82785545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62812 head of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25724 BRD-K33986892 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2587 BRD-K11873306 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33575 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.876965 PCCB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00374628 basomedial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.397 H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K9ac_Peripheral Blood Mononuclear Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K63997411 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47707 H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.995592 paraventricular nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.978064 cytoplasm LOCATE Predicted Protein Localization Annotations 1.0 null JHUEM3 CCLE Cell Line Gene CNV Profiles -1.0 -1.37077 BRD-K05841284 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51137 PAPSS1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00454017 BRD-K86677819 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62017 H3K4me3_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K90444258 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.54272 MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CP in rostral hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.848831 CKS1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0071156 CKM LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00860346 amygdalohippocampal transition zone, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.876502 H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null lingual gyrus, right, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.56366 DTHD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00441184 BRD-K19220233_JNK-9L_HME1_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.894154 RPL13A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00544511 RCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.902027 SPATS2L LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00674701 TNNI3K LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00508112 BRD-K78615842 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30266 CTCF ENCODE Transcription Factor Targets 1.0 null layer IIIa of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.63855 PON1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00695525 TNFRSF10B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00911702 Fetallung BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.23872 STK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00492703 MKN74 CCLE Cell Line Gene CNV Profiles 1.0 1.80606 midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.67465 SERPINB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00491071 BRD-K44298652 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57296 RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SAA4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0073115 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.09181 ventral tegmental area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00149 FASTKD3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00866181 BRD-K79090631_CGP-60474_A375_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K05886700 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04552 NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.012 PIM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00502682 basolateral nucleus (basal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.890336 external granular (germinal) layer of upper rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.53934 BRD-K72264770_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EBC1 CCLE Cell Line Gene CNV Profiles 1.0 2.01392 GABPA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null WNT7A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00573361 H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FCRL2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00514779 AKT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00369124 ventral posterior medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03474 CSGALNACT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00812091 H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K95033255 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54884 layer IIIb of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12956 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K96663576 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25383 OVTOKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13329 SH2D1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00483091 SK-MEL-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.927665 AZIN2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00497053 pineal gland Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.00406 USP7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00725025 H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K69671285 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12695 H3K27me3_H7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null STK17A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00685977 CAKI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.919368 IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2173 H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07773 NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.995592 NUGC-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.5647 BRD-K46942548 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55079 pontobulbar body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36203 BRD-K72414522_AZD-5438_HME1_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null tardbp_19910924_hek293e_lof_human_gpl570_gds3730 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.503994 BRD-K83547183 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.11887 H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null mammillary body, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.26391 H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.91905 BRD-K83289131_CAY10618_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.49738 GlobusPallidus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.891498 CP in caudal hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.999224 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.78976 BRD-K41887762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2961 BRD-K52075040_-666_RMUGS_6.0_h_44.4_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00519302 BRD-K97330035 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10319 BRD-K28370158 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00503 ADSS2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00488342 LDHAL6A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00726809 H3K4me3_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K33151492 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19371 H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RAD21 ENCODE Transcription Factor Targets 1.0 null BRD-K85767870 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1879 Dorsal claustrum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22301 RORC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0087062 RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K64860451 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.44543 MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H358 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09396 H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null organelle LOCATE Predicted Protein Localization Annotations 1.0 null HELA BioGPS Cell Line Gene Expression Profiles -1.0 -1.81625 III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.2296 inner CP in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.985586 BRD-K30964193 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.00226 H3K4me3_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null nucleus subputaminalis Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02719 BRD-A52729710 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.148 H3K4me3_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NQO1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00629958 POU2F2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00728121 COLO679 CCLE Cell Line Gene CNV Profiles -1.0 -1.82382 CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34555 ELL2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00650527 MPL LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00605127 BRD-K72359187 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43183 BRD-K43389698_BMS-387032_A549_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.904828 SP1 ENCODE Transcription Factor Targets 1.0 null BRD-K07013504 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26284 HS 936.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.952642 UACC812 CCLE Cell Line Gene CNV Profiles -1.0 -1.39272 BRD-K71415389 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.24642 basal nucleus of Meynert Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.8337 Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.13555 BRD-K05322955 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09504 H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SG in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.36112 JAM2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00668716 HCC38 CCLE Cell Line Gene CNV Profiles 1.0 1.54686 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K49908787 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66199 BRD-K02321382 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18136 BRD-K97943226 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31163 IFNL3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00461866 H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TBK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00719642 BRD-K63547380 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.09319 H3K4me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TestisSeminiferousTubule BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.68357 BRD-K92241597_CHR 2797_HT29_6.0_h_80.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K21423945 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2016 TNNI3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00584881 GABPA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KCNK12 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00318977 BRD-K25757432 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46346 H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0054 BRD-K43992612 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.15861 occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.37137 POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K86884344 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.08096 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.876965 H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-A56359832_-666_WSUDLCL2_6.0_h_160.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null A498 BioGPS Cell Line Gene Expression Profiles 1.0 0.974499 H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RENBP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00529695 NDUFA8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00623919 IL2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00665017 BRD-K56032186 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18937 NCI-H2110 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.77119 BRD-K46313713 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18796 inner CP in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00746 BCAT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00764279 BRD-K09663164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.93652 PLXNA4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00610993 H3K27me3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSDMB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00610086 tylosin-tartrate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12099 CD34+ BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.959513 MAFK ENCODE Transcription Factor Targets 1.0 null imatinib_homo sapiens_gpl96_gds3046 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00627 ALPK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00708284 H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null RSKR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00610441 H3K4me3_Brain Germinal Matrix Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ALPG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00699134 H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null COLO 794 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24115 BRD-A75409952_wortmannin_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null medial mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.64172 STK38L LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00531925 BRD-K83755051 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29198 Ovary BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.57077 LIVF001-023 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.39329 CTCF_GM13976_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NCIH1694 CCLE Cell Line Gene CNV Profiles -1.0 -1.88821 KDM2B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00432644 pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.30235 GCKR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00599244 VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.32238 MYC ENCODE Transcription Factor Targets 1.0 null HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2018 BRD-K39516553 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0668 BRD-K20617704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02319 EGLN3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00444826 BRD-K49525275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91995 BRD-K54212583 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69875 SUPT11 CCLE Cell Line Gene CNV Profiles -1.0 -1.35982 ASPA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00700846 A172 BioGPS Cell Line Gene Expression Profiles -1.0 -0.867829 planum temporale, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.915406 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.833104 ARF6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00685737 MDAMB361 CCLE Cell Line Gene CNV Profiles -1.0 -2.03641 H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUCLG2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00734553 BRD-A86629089 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14671 H3K4me3_Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null inner SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05709 H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TOP1MT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00595366 H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K60635455 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25111 central gray of the pons, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.1997 GALK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00469445 BRD-K33767223 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.40274 inner CP in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.34195 TRPA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00751231 GLS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00763334 BRD-K50443235 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.91995 BRD-K15291808 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30723 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K65137277 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13315 BRD-K74767736 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22711 BRD-K16411174 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11129 BRD-K69918256 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25219 H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K27058632 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.8855 BRD-K19220233_JNK-9L_A375_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null REST ENCODE Transcription Factor Targets 1.0 null WIDR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.902027 RHOH LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0045448 VIIAt Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.15261 globose nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.21839 BRD-K77345736 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.45367 BRD-K73581966 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37763 MMP15 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00556416 inner CP in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06665 BRD-K57734337 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23715 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PTGDR2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00455584 layer VI of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -3.41306 POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PLA2G2D LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00470934 BRD-A73590800 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64136 TYK2_knockdown_35_GDS4754 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.64126 BRD-K54881917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0015 PRSS36 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00678279 BRD-K69984954 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69555 H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PIK3C3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0056738 RL952 CCLE Cell Line Gene CNV Profiles -1.0 -1.74472 H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FXYD2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00813506 BRD-K21040167 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69908 BRD-K22715231 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12442 59M CCLE Cell Line Gene CNV Profiles -1.0 -1.56686 SNU1272 CCLE Cell Line Gene CNV Profiles -1.0 -1.34072 BRD-K89574562 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23673 inner CP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23217 BRD-K69932463_AZD-8055_HME1_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K73387470 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56761 BRD-K87472370 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71856 SPEG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00614749 BRD-K01979737 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41306 BRD-K43271856 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13098 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K94325918_-666_MDST8_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K74705119 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.62882 H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K46639367 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32339 BRD-K17140735_-666_SW620_6.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.90573 PLK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00636425 BRD-K19320442 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18169 VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.259 HKDC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00610233 nucleus of the diagonal band, left, vertical division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.25107 RSPH9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00521383 BRD-K27914478 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58855 H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PNP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0031081 BRD-K05940224 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86458 PBX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K67578145_GDC-0879_HEPG2_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PTPA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00540326 POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HUH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30963 H3K27me3_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCR5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00483013 BRD-K43390655 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53814 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K40175214_torin-1_HME1_3_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PLCL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00617392 H3K27me3_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A20463452 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65317 BRD-K12306640 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25379 NCVADR RES BioGPS Cell Line Gene Expression Profiles 1.0 0.857093 BRD-A45889380_QUINACRINE HYDROCHLORIDE_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCIH660 CCLE Cell Line Gene CNV Profiles -1.0 -1.51347 HCC1806 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.83309 BRD-K18245187 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05666 ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K64890080_BI 2536_SNUC4_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K18296568 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.27032 RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.87372 oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19279 BRD-K39809702 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03204 BRD-A28153253 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15501 DGKQ LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00931718 BRD-K77795481 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05262 VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.947381 H3K27ac_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KYNU LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00551142 GRIN3B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00818832 IFNA14 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00404249 H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K76654183 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16239 BRD-K68300789 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.11702 BRD-K12524155 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10105 H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null E2F6_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CKMT1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00794578 EZH2 ENCODE Transcription Factor Targets 1.0 null POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TFF2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00596574 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13329 BRD-K71221636 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.42122 RIDA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00541842 BRD-K75036062 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5115 CKMT2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00621814 BRD-A30962679 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00774 BRD-K21313369 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48239 RFX5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2722 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17028 BRD-K30917841 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.91971 RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null outer CP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2415 JHH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00627 LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.952642 H9 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.922143 BRD-K38450726 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.32531 ARPC5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00565911 H3K9ac_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null deep layers of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.18665 JURKAT BioGPS Cell Line Gene Expression Profiles 1.0 1.43383 C32TG Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.840509 ORM2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00582307 SETD1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00497985 H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27me3_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CBLIF LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00644501 BRD-A81407814 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.92807 bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.859708 H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null FHL2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00491832 TYK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00547493 BRD-K68665079 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56592 SG in dysgranular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.960479 BRD-K21143905 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25805 BRD-K84932026 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15602 SLC5A2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00528275 H3K4me3_CD3 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NME3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00551875 KASUMI1 CCLE Cell Line Gene CNV Profiles -1.0 -2.75441 KLF10 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00420528 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA ENCODE Transcription Factor Targets 1.0 null BRD-K60866521_idelalisib_HA1E_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TNNC2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00884762 BRD-K14671528 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.4773 MTTP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00588441 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K64800655_PHA-793887_MCF7_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.902027 BRD-K22608982 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76566 BRD-K39858575 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48128 SEPHS2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0073616 lateral hypothalamic area, tuberal region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.50818 H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NAP1L4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0052003 VRK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0070949 BRD-K22229373 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5007 BRD-K01787291 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12403 BRD-K37850190 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19116 H3K4me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KALRN LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00554471 CR1L LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00568525 external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.972368 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GLP1R LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00471372 PBX3 ENCODE Transcription Factor Targets 1.0 null BRD-K38417094 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63193 MAPK1IP1L LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00365921 TestisGermCell BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.19959 BRD-K13646706 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08305 outer CP in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.827083 H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K76742876 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06926 BRD-K66632266 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24048 KRTCAP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00642318 TNFRSF11A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00654274 BRD-K21409337 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13998 H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-U41416256_THZ-2-98-01_HME1_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BLK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00610236 RNASE3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00544524 BRD-K23280067 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17928 E2F6_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCL4L2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0057201 BRD-K18620798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17577 BRD-K67022703 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03437 RKN CCLE Cell Line Gene CNV Profiles 1.0 1.64154 G122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07773 A549 CCLE Cell Line Gene CNV Profiles 1.0 1.36902 BRD-K19315592 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58243 MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null central nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.46429 LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.49738 RUNX1T1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00460887 H3K27me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCIH2110 CCLE Cell Line Gene CNV Profiles -1.0 -1.57545 TYK2_knockdown_176_GSE44652 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.64126 BRD-K49371609_528116.cdx_MCF7_24.0_h_0.09_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRAF LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00982849 III Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.825261 BRD-K37203382 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51305 IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22718 SP1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BGC823 CCLE Cell Line Gene CNV Profiles 1.0 1.45629 outer CP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04983 imatinib_homo sapiens_gpl96_gds3042 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K89274813_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CI-1040 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77411 outer CP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.850959 IFNA21 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00420347 BRD-K24689407 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19583 IP6K1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00551539 H3K4me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K69932463_AZD-8055_HME1_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null JL1 CCLE Cell Line Gene CNV Profiles -1.0 -1.35363 parataenial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.54748 H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K34620971 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11346 BRD-K73789395_ZM 336372_HT29_24.0_h_102.71_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K71493061 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53039 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null supramammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.852243 strychnine-hcl LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13467 POLR2A ENCODE Transcription Factor Targets 1.0 null H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30963 HDQP1 CCLE Cell Line Gene CNV Profiles 1.0 2.28103 H3K4me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null stratum radiatum of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.80702 CDH1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0055902 RFK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00605717 REST_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDK17 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00876179 H3K4me1_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KDM2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00433633 POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JMSU1 CCLE Cell Line Gene CNV Profiles -1.0 -2.13639 PHC3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00483654 H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null inner CP in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.24891 PKN3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0064053 A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.876965 BRD-K44622259 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.17102 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ALPK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00500359 ITGB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00744576 IX Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1212 BRD-K52973286 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12304 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.940815 nucleus of Darkschewitsch, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.885425 NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.61825 UMUC1 CCLE Cell Line Gene CNV Profiles 1.0 2.24798 H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null WEE1_druginhibition_307_GSE38972 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.05232 H3K4me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SLC1A7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00480377 flurandrenolide LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05423 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.835821 BRD-K94347944 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0165 GABRR1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00478447 PLA2R1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00548199 RKN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54392 BRD-K68574010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06926 NCI-H1781 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.90573 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null deferasirox_homo sapiens_gpl570_gds3558 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TOP2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00373967 NUGC2 CCLE Cell Line Gene CNV Profiles -1.0 -2.73727 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD51C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00364725 polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.71615 DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05258 MAX ENCODE Transcription Factor Targets 1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K60255752 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68298 H3K4me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ROBO1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00551689 BRD-K91137832 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38276 BRD-K64800655_PHA-793887_A549_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GPC4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00585033 BRD-K66939340 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2675 BRD-K76611906 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16491 BRD-K63068307_ZSTK-474_HME1_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K35100006 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34498 HT-29 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.901213 ZNF384 ENCODE Transcription Factor Targets 1.0 null POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K76628522 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.41219 H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ribavirin_homo sapiens_gpl570_gds4391 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K79090631_CGP-60474_A549_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null anterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02552 ADSS1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00849368 BRD-K58941403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43729 MXRA8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00497543 NDUFB6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00599791 RPS6KA5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00554247 BRD-A48913311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31372 H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K82823804_PD 407824_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K24523560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.91661 BRD-K42918627_GSK-2126458_HME1_3_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MKN-74 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1398 MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HARA CCLE Cell Line Gene CNV Profiles 1.0 1.76959 H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K72636697_QL-X-138_MCF7_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Primary T cells from cord blood Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -2.0876 DMS153 CCLE Cell Line Gene CNV Profiles -1.0 -1.45002 MCF10DCIS.COM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.995592 COLO-818 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.49707 HEC265 CCLE Cell Line Gene CNV Profiles -1.0 -1.8144 FGB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00626514 BRD-K72034681 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16055 BRD-K40220562 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68722 H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HUH6 CCLE Cell Line Gene CNV Profiles -1.0 -1.63747 BRD-K78126613_MENADIONE_NOMO1_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A78982410 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34766 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GPER1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00551038 BRD-K49108064 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.98703 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC2998 BioGPS Cell Line Gene Expression Profiles -1.0 -1.8957 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.988771 CD300LF LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00626005 BRD-K59207957 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18924 H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K04108962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.87061 BRD-K76900919 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.86753 BRD-K44426506 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06674 RBBP5 ENCODE Transcription Factor Targets 1.0 null BRD-A19037878_trichostatin A_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null inner SZ in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01529 H3K4me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K88384015 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.57125 IP6K3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00775793 caudal subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16013 H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null subthalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.967083 AXL LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00622113 WDR87 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00506989 GATA2_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.993749 MMAA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00577051 BRD-A21584801_brivanib_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null WNT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00669166 basal ventral medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.889106 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null PCSK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00508998 BRD-K94629607 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36935 COLO 679 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.44034 CAL78 CCLE Cell Line Gene CNV Profiles -1.0 -1.45776 BRD-K22874335 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43851 H3K4me2_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null UACC257 BioGPS Cell Line Gene Expression Profiles 1.0 1.0603 ARL5B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00768872 BRD-K90697694 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01507 KDM4A ENCODE Transcription Factor Targets 1.0 null H3K4me3_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27me3_H7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DorsalRootGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.914295 BRD-K40175214_torin-1_HME1_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null outer CP in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.894 H3K4me3_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.849702 rostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05768 BRD-K07303502_Arachidonyl trifluoro-methyl ketone_SKLU1_6.0_h_80.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K30628727 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47218 BRD-K42995703 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00462 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.854136 imatinib_homo sapiens_gpl96_gds3045 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K56977200 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13468 BRD-K84143716 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06193 H3K4me1_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.52337 H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ES-I3 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.43043 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POMC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00682058 basomedial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13843 EKVX BioGPS Cell Line Gene Expression Profiles -1.0 -0.972339 YARS2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00531256 BRD-K27083306 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.66813 BRD-K72437469 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80935 olfactory tubercle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14074 BRD-K18290923 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09473 VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07998 MUTZ5 CCLE Cell Line Gene CNV Profiles 1.0 1.55197 BRD-K01759041 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2606 BRD-A67788537_Salermide_HT29_6.0_h_120.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NEU2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00510956 BRD-K05228434 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30152 BRD-K09250623 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44451 H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GPR183 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00476021 BRD-K63068307_ZSTK-474_A375_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null iPS-18 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.20988 H3K4me1_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K06593056_-666_A549_6.0_h_20.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null KIF19 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00613615 TAF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null imatinib_homo sapiens_gpl96_gds3043 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null caudal putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06792 H3K9ac_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K98595604 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36914 BRD-K71537579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25952 H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K45642123 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3687 GRIN2C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00612879 BRD-K55220938 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61792 KYAT3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00606967 EZH2_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K06529600 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.52251 DU145 BioGPS Cell Line Gene Expression Profiles 1.0 1.67207 HT1197 CCLE Cell Line Gene CNV Profiles -1.0 -1.333 H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K39176069 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28201 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K42918627_GSK-2126458_HME1_3_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Crus I, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.906819 NEK5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00516376 E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.49707 H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.859284 OVCAR4 CCLE Cell Line Gene CNV Profiles 1.0 2.06423 substantia nigra, pars compacta, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.66633 RFX5 ENCODE Transcription Factor Targets 1.0 null BRD-K13898728 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21411 BRD-K37906761 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0538 BRD-K46739745 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5751 BRD-K88573743_A443654_HT29_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K07691486_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TRRAP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00692332 BRD-K70979181 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4479 CFPAC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.840509 BRD-K03321770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56139 AIP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00503173 BRD-K42918627_GSK-2126458_HME1_3_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCC4011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.87372 TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.90573 H3K4me3_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CLK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00767761 MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K83567669 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32191 COLO 678 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.982906 BRD-K12271646 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68917 BRD-K88573743_A443654_HT29_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RIOK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00506008 MOR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67796 BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.50054 BRD-K81418486_vorinostat_SW620_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.919368 BRD-K05041614 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24349 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LOVO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10877 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K95146554 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04902 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K25269762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44314 outer CP in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16999 NCI-H322M COSMIC Cell Line Gene CNV Profiles 1.0 3.12177 supraoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.76761 IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.755 RORA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00607137 BRD-K01877528_TL_HRAS26_SNUC4_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.09122 substantia nigra, pars reticulata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.926854 AK9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00634668 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HCC1806 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 BRD-K04269696 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22284 RAD21_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null outer SZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2497 BRD-K61451401 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.40314 BRD-K12502280_TG101348_NOMO1_6.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K48143921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22678 preoptic region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.51144 H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.89809 BRD-K12175788 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65282 BRD-K47881755 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79823 BRD-K60918542 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52637 MYH2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00612424 inner SZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01177 MYB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00376273 BRD-K73395020_ARP 101_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TIAL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00583706 NCI-H2803 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13329 VIIB, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.41346 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K90741031 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.60008 anterior orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.96845 SKMEL5 BioGPS Cell Line Gene Expression Profiles -1.0 -1.08102 NCIH2126 CCLE Cell Line Gene CNV Profiles -1.0 -2.3514 H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K10189430 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.88412 BRD-K98117883 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6457 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IZ in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.935823 BRD-K50000283_PHA-767491_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13696 CHRNA2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00479175 NEK9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00429099 BRD-K63626200 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59656 H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null E2F6 ENCODE Transcription Factor Targets 1.0 null H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TAFAZZIN LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00504736 HCC1599 CCLE Cell Line Gene CNV Profiles -1.0 -1.70446 H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NMB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.005357 BRD-K08458391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.96911 NCI-H2126 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.20339 E2F6_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K34447537 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25561 U251MG CCLE Cell Line Gene CNV Profiles 1.0 1.38743 ALB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00804289 central nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.56411 CES1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00688278 substantia nigra, pars compacta, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.48593 H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K42918627_GSK-2126458_MCF10A_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K45398957 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.09569 H3K4me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K28578807 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31037 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-A85216385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51787 SNB19 BioGPS Cell Line Gene Expression Profiles -1.0 -0.994104 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SU-DHL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20386 upper (rostral) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22589 stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.28973 H2AFZ ENCODE Transcription Factor Targets 1.0 null H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.21655 H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null inner SZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09063 AOX1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00368102 KNS42 CCLE Cell Line Gene CNV Profiles 1.0 1.57563 H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Testis BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.26179 BRD-K86722849 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14754 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K18416855 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5072 NCIH226 CCLE Cell Line Gene CNV Profiles -1.0 -1.43405 BRD-A47829399_artesunate_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ULK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00680154 HUNS1 CCLE Cell Line Gene CNV Profiles 1.0 1.45183 RUSC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0057637 H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.901213 BRD-K85909950 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17849 BRD-K06792661_Narciclasine_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CDK10 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00722861 LRGUK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00719166 BRD-K63987422 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.964 H3K4me3_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null body of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0691 ATP2A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0056557 BRD-K12111274 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54017 cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.07987 BRD-K33044659 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01601 VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.861293 Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.58212 UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.81755 BRD-K94992087 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17148 BRD-K62193937 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42965 BRD-K91818277 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22509 COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05323 SLC6A8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00863789 H3K4me3_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null nucleus LOCATE Predicted Protein Localization Annotations 1.0 null KCNC4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00904289 STAT2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00506215 BACE1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00612389 HH CCLE Cell Line Gene CNV Profiles -1.0 -1.73569 MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.833104 FYB1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00474193 cortico-medial group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.924232 BRD-K20895937 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57787 SHSYSY-RA BioGPS Cell Line Gene Expression Profiles 1.0 1.15335 BRD-K06845853 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75443 MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27591 GLDC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00579121 LYAR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00540336 lower (caudal) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22523 H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IL21 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00717829 H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null lateral tuberal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.76029 BRD-K21680192_mitoxantrone_MCF7_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.933505 BRD-K73261812_-666_LOVO_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TPR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0042603 BRD-K99681648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69241 CBX3 ENCODE Transcription Factor Targets 1.0 null BRD-K81801123 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45218 BRD-K79090631_CGP-60474_A549_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null paraventricular nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.1715 H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CDC42BPG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00692616 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null supraoptic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.879761 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K04219533 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03619 LUDLU1 CCLE Cell Line Gene CNV Profiles 1.0 1.48931 BRD-K66110520 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05514 TestisIntersitial BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.7888 NCI-H2052 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30963 DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13696 H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO818 CCLE Cell Line Gene CNV Profiles 1.0 1.34525 BRD-K90736603 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55289 KIF3B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00403198 BRD-A55408860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63087 SKMEL3 CCLE Cell Line Gene CNV Profiles 1.0 1.68985 BRD-K92712671 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72751 SP1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null TEX14 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00506008 RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17086 BRD-K26941844 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01386 UBE2D3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00646699 JL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45938 LXF-289 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.876965 BRD-K84246050 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.06167 superficial layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.985924 LMTK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00560222 BRD-A47416464 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.45352 SNRK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00518792 BRD-K92701606 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.02002 SW 1463 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09396 BRD-K06431647 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.99125 BRD-K26108750 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35919 H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.44807 BRD-K77320034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91887 E2F6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOLR1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00509436 BRD-K38118226 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86336 dorsorostral division of MFC (area 32) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.845993 OSM LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00530906 JHESOAD1 CCLE Cell Line Gene CNV Profiles 1.0 1.4706 SIN3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K32760954 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08534 HIF3A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00483899 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0053643 HCA-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.42217 GSTA4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00609846 BRD-A05883068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58856 TPK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00516938 BRD-K74176533 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.0976 BRD-K28995832 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49802 TIMM23 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00573498 IDH3A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00534015 H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null corpus callosum Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.862639 POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1806 COSMIC Cell Line Gene CNV Profiles 1.0 3.12177 CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRKL LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0198841 H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K81035073 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67762 BRD-K56301217_A112550.cdx_NCIH2073_6.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null lomofungin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.07943 BRD-A81615860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00108 H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K66573697 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0306 BRD-K32145037 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03986 BRD-K21990363 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.9584 BRD-K52882725 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10783 H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.925623 H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MC116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.3444 BRD-A96334094 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76315 OGFOD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00684151 BRD-A11130173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10978 BRD-K67096634 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13956 BRD-K94049419 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07508 H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PPP1R16B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00493784 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AFG3L2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00356189 BRD-K64937432 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01495 BRD-K88583132 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07986 dorsal lateral geniculate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.76832 H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PPCDC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00718562 TAF1 ENCODE Transcription Factor Targets 1.0 null BRD-K11643336 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26189 OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.332 BRD-K85977749 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3777 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08464 CYP51A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00437398 BRD-K58779593 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.92435 I-II Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.854709 BRD-K80851151 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42493 Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.55489 BRD-K91577886 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4956 BRD-A71722688 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.03142 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EWSR1_KD_GDS4962_469_human_Ewing sarcoma and prostate cancer GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CPS1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00486678 NELL2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00507994 BRD-K70949282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08681 H3K27ac_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K92134254 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70256 H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KYSE-150 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.95874 BRD-K17299182 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08028 VEGFC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00689285 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1869 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36214 BRD-K54660148 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54366 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K63420290 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15162 IPPK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00422743 GUCY2D LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00690313 BRD-K25710391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.68011 rostral division of VL Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.36574 H3K4me3_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null lateral hypothalamic area, anterior region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04549 GLRX2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00460982 SHSYSY+RA BioGPS Cell Line Gene Expression Profiles 1.0 1.27164 deep layers of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.874523 NCIH1781 CCLE Cell Line Gene CNV Profiles 1.0 1.65784 BRD-K50851442 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53592 BRD-K22974051 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34966 BRD-K64800655_PHA-793887_A375_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PRKACG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00630484 BRD-K94452277 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07799 CD109 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00607762 BRD-K64601990 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29872 H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K41307363 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81046 NCI-H1930 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.833803 BRD-K90475322 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.5145 MXI1 ENCODE Transcription Factor Targets 1.0 null NCIH322 CCLE Cell Line Gene CNV Profiles 1.0 1.97202 BRD-K33272502_DG-041_A673_6.0_h_40.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null IRF2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00515842 LCP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00575007 BRD-K36923996 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83374 BRD-K44427106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24827 BRD-K60772078 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38589 AICD_Induced expression / Over-expression_GDS1979_288_human_SHEP-SF neuroblastoma GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K20068050 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14079 H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K27726368 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54045 EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.62636 stratum pyramidale of caudal CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.971325 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SF268 BioGPS Cell Line Gene Expression Profiles 1.0 0.922027 H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null BRD-K15160697 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2104 H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K80495774 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01623 NDUFS5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0049042 central gray substance of midbrain, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.952764 KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.64398 CCKBR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00530206 MICALL2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00498245 BRD-K96970199 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03347 CP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.91841 LDHA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00405944 BRD-K97977764 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28203 TE10 CCLE Cell Line Gene CNV Profiles 1.0 1.3787 KAT7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00558264 KYSE150 CCLE Cell Line Gene CNV Profiles 1.0 2.50687 BRD-K50000283_PHA-767491_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K83122599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41167 K562 BioGPS Cell Line Gene Expression Profiles 1.0 2.41625 TRPV4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00667389 BRD-K50721666 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00114 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K74811560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.23841 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.26578 CALU3 CCLE Cell Line Gene CNV Profiles -1.0 -2.08659 BRD-K40958081 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33341 KYSE-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.012 H3K4me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SNU1214 CCLE Cell Line Gene CNV Profiles 1.0 1.445 BRD-K14813155 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00313 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null outer CP in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11777 BRD-K05928130 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10761 BRD-A45498368_WYE-125132_MDAMB231_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K49443464 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.31863 BRD-K29802952 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42667 VIIAf Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.31516 imatinib_homo sapiens_gpl96_gds3049 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ARHGEF2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00418922 SP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.46235 H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K01757377 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.13751 BRD-K93484038 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27144 SIN3A ENCODE Transcription Factor Targets 1.0 null OFD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00476668 H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K15779027 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.10116 BRD-K50670216 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32616 E2F6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NOLC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00376091 rostral migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.985127 Wholebrain BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.05156 BRD-K73357447 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67917