association	dataset	threshold value	standardized value
GSE168401_2_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43122
Dbf4-dependent protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.776
cell part	GO Cellular Component Annotations 2015	1.0	null
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17051
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827143
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.86244
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.997817
GTEX-SE5C-0426-SM-4BRUI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19605
TP53-23651856-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.42632
GSE184356_1_v_2_tfam_human	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.39757
Lung adenocarcinoma_LUAD_TCGA-44-7661-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE111247_2_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Respiratory epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.729
Lung adenocarcinoma_LUAD_TCGA-78-7540-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
DACH1	ChEA Transcription Factor Targets	1.0	null
BRCA1	ENCODE Transcription Factor Targets	1.0	null
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.078038
MYC	ENCODE Transcription Factor Targets	1.0	null
Perturb_6799_KD_SNHG5_SRP068373	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endopiriform nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19726
RARA-24833708-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943094
Hereditary retinal dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.223
orbital frontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.845679
GTEX-U4B1-1926-SM-3DB9E	GTEx Tissue Sample Gene Expression Profiles	1.0	2.79653
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDMYZ	DepMap CRISPR Gene Dependency	1.0	4.94807
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.254
Norepinephrine (hydrochloride)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0227987
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.45
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Inward rectifier potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.834
Lung squamous cell carcinoma_LUSC_TCGA-MF-A522-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-33-BM51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331458
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45935
pancreas	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
posterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20884
EFO-27	COSMIC Cell Line Gene Mutation Profiles	1.0	null
AE-37-MC27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215625
PMC12184396-pnas.2421883122.sapp.pdf-30-BCL11A_BCL11A	Rummagene Transcription Factor Associations 2026	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Inner hair cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.745
Cytosolic region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.702
NCI-H1105	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KP4_PANCREAS	CCLE Cell Line Proteomics	1.0	6.42465
Field CA1, stratum radiatum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73051
RELA	ENCODE Transcription Factor Targets	1.0	null
mantle zone of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21757
FOXF2	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC8033524-EMMM-13-e13162-s004.xlsx-d_GREAT_on_NFIB_bound-genes_HF-Unnamed_0_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201877_1_v_0_yap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29335
SP in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.891373
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213588_10_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
flj23420	GeneRIF Biological Term Annotations	1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0556
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893931
GSE130676_0_v_1_suds3_human	RummaGEO Gene Perturbation Signatures	1.0	null
RUNX1-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A3LQ-01A-21R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dentate (lateral) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23415
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Abnormality Of The Outer Ear	DisGeNET Gene-Disease Associations	1.0	null
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217552_3_v_2_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GABA receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.391
r4 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24648
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03475
Autoimmune disease of central nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BPH-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.81275
HDAC2_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
oocyte	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.59846
includes	GeneRIF Biological Term Annotations	1.0	null
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredPeptides-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.57
GTEX-XPVG-2526-SM-4B66D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.845611
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
monoatomic anion transmembrane transport	GO Biological Process Annotations 2025	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SL-01B-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anophthalmia	MGI Mouse Phenotype Associations 2023	1.0	null
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.67548
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
anion	GeneRIF Biological Term Annotations	1.0	null
VDR-33458620-PRIMARYEPITHELIAL-HUMAN-PROSTATE	ChEA Transcription Factor Targets 2022	1.0	null
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239439
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03364
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-200c	TargetScan Predicted Conserved microRNA Targets	1.0	0.085563
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.25
GTEX-O5YW-0426-SM-3MJHJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903888
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.884
NCIH838	CCLE Cell Line Gene Expression Profiles	-1.0	-1.95127
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
JUN_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRF_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562	DepMap CRISPR Gene Dependency	1.0	5.07364
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14913
periventricular stratum of r5Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03523
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC7519331-pnas.1921408117.sd11.xlsx-ERM_OMM_DualBiotinylated_APEXSq-Ensembl_Gene_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUZ12_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.18483
GSE193993_1_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of neutrophils	HPO Gene-Disease Associations	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.477056
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46669
IGR1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46261
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-2666-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.824657
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05548
Integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
abnormality of leukocytes	HPO Gene-Disease Associations	1.0	null
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.874998
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.7611
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052532
CB-55-AK76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234341
MAP4K4	MSigDB Cancer Gene Co-expression Modules	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A1HS-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09122
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
r4 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.586
Lung squamous cell carcinoma_LUSC_TCGA-58-8391-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5007-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-A8OW-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE131649_2_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-21-WS76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204784
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE154577_7_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10593
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SIX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_4_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146982_3_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19783
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.949131
nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.935324
N1E-115 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.141
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05312
GSE242083,GSE242098_3_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-6216-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.625395
LN319	CCLE Cell Line Gene Expression Profiles	1.0	1.74866
abnormality of the mouth	HPO Gene-Disease Associations	1.0	null
Lung fibroblast	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MD-86-UW46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275106
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.7074
GTEX-RUSQ-0426-SM-47JWR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26236
SARS-BatSRBD_36Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.3668
PMC12703482-AMS-21-5-213605-s2.xlsx-Supplementary_Table_SXI-SMR_results_of_expression_levels_of_VDR_target_genes_in_liver_and_risk_of_hepatocellular_carcinoma_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3144-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Rectum adenocarcinoma_READ_TCGA-AH-6643-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XYKS-2626-SM-4BRUT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24532
RMGI	CCLE Cell Line Gene CNV Profiles	-1.0	-2.58965
AD-58-PW17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.673798
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CF-81-DS26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214465
496100315_TCx_no dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.38901
Prostate adenocarcinoma_PRAD_TCGA-EJ-5514-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Elagolix sodium_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0166349
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sin3a_22783022_mcf7_lof_human_gpl570_gds4388	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.00348
GTEX-N7MT-0011-R5a-SM-2I3G6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850647
phenotypic abnormality	HPO Gene-Disease Associations	1.0	null
all	GeneRIF Biological Term Annotations	1.0	null
retropontine reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12358
GSE134375_3_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41219
Leukodystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.773
abnormality of cellular immune system	HPO Gene-Disease Associations	1.0	null
CC-03-PW00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207637
EGR1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bronchial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
EP300_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.882607
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959237
POU2F2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE254649_2_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
connective tissue	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CD-35-BD44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20141
105_ACTG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.08118
Pancreatic beta cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.819
TestisLeydigCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.55754
PBX3	ENCODE Transcription Factor Targets	1.0	null
EA-22-SB72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.41218
Perturb_3785_KD_TOX4_SRP041162	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.28363
GSE195559_2_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10022497-Table2.XLSX-ZEB1YAP1_genes_and_H69_genes-ZEB1_YAP1_activated_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14445
caudal prosubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.873955
CMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19751
SRF_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AR-35650195-DSRCT-HUMAN-MESENCHYMAL-SARCOMA	ChEA Transcription Factor Targets 2022	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A512-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.467531
Mueller cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.94
lysosomal membrane	GO Cellular Component Annotations 2025	1.0	null
CB-62-TB77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203808
localized	GeneRIF Biological Term Annotations	1.0	null
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03364
Sarcoma_SARC_TCGA-IF-A4AK-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MJ-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980976
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-O5YV-0426-SM-3LK66	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998355
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.13517
SW1116	CCLE Cell Line Gene CNV Profiles	1.0	2.16487
GTEX-XUJ4-0326-SM-4BOP9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70661
CTCF_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Osteoarthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
abnormal thymus medulla morphology	MGI Mouse Phenotype Associations 2023	1.0	null
Supraoptic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.086
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF5	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.474588
H3K9ac_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_6496_KD_PIEZO1_SRP392492	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_12247_KD_ESRRA_SRP028155	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Inward rectifying potassium channel	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.396
Brain - Frontal Cortex (BA9)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.972185
PMC9643473-Table1.xls-MAF_0_005-Gene_refGenecanonical_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QVJO-0011-R4A-SM-2S1QL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841201
Perturb_17822_KO_Stat1_SRP277338	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Erythroid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.146
CSTB_KO_GSE47516_678_mouse_mouse cerebellum at P30	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.682948
BF-22-EP86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247187
Infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7379-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCFC1	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ACOT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04736
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A550-01A-61R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ion channel complex	GO Cellular Component Annotations 2015	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HI-7170-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242555_1_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8307
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.453656
Perturb_14445_KO_Mtor_SRP144775	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.99057
Posterior spinal root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.638
BFTC905	CCLE Cell Line Gene Expression Profiles	1.0	1.50181
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
S0-EE-Y6WJ_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346976
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-87-II61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.436687
MCF7_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112443
MITF_02_85	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59619
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.409
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94175
abnormality of myeloid leukocytes	HPO Gene-Disease Associations	1.0	null
Epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.729
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_8997_KO_KDM6A_SRP309312	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.17515
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04449
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1275
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
transmembrane transporter complex	GO Cellular Component Annotations 2015	1.0	null
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-03-QM41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.664774
KYO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73614
morphine_mus musculus_gpl6246_gse17731	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2111
Head and neck cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
PMC10037107-JEM_20221755_TableS6.docx-0-IL4-p_D419G-STAT6_targets_in_Jurkats_2_STAT6	Rummagene Transcription Factor Associations 2026	1.0	null
Chronic Otitis Media	DisGeNET Gene-Disease Associations	1.0	null
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.415
POLR2G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21337
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Baricitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146158
HEC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAX_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Leucine-rich repeat, typical subtype	InterPro Predicted Protein Domain Annotations	1.0	null
Malignant tumor of pancreas_saliva_GSE14245	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.25883
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AZD-7648_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0200847
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.76
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41764
NRM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66226
VA-92-QP54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.684494
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.884773
Recurrent Skin Infections	DisGeNET Gene-Phenotype Associations	1.0	null
A549_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229027
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3HY-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.401
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
GSE211128_2_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.447445
TestisIntersitial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.971152
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91107
GSE171180,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OHPM-1826-SM-2YUNF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986338
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AU-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AD-72-RI24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09526
GTEX-T2IS-2626-SM-32QPP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35045
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE167474_2_v_3_naa40_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-13-CX28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.38212
DD-43-WW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24205
UBA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43244
MXI1	ENCODE Transcription Factor Targets	1.0	null
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pyramidal layer of S	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11271
HOXB4-20404135-EML-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
PMC7991738__F1	PFOCR Pathway Figure Associations 2024	1.0	null
brain	HPA Tissue Gene Expression Profiles	1.0	1.60342
Perturb_7304_OE_SF3B1_SRP286876	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.46368
layer 3 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84369
Perturb_3455_KO_Mecp2_SRP017936	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.84466
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.26165
HD-62-KE69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.31914
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endometrium_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.16703
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33798
hydronephrosis	MGI Mouse Phenotype Associations 2023	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6464-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
malabsorption	HPO Gene-Disease Associations	1.0	null
hsa-miR-4290	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
GALNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30844
mRNA_POU5F1_16518401	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.82288
Transmembrane transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-V955-2626-SM-3NM9F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53791
TE-9	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.06279
RBM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46398
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
channel	GeneRIF Biological Term Annotations	1.0	null
TCF12/HEB-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_15686_KO_Stat1_SRP277338	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
H3K18ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
U266B1	CCLE Cell Line Gene CNV Profiles	1.0	1.46691
DACT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03081
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HEB	MotifMap Predicted Transcription Factor Targets	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2870-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24506
hsa-miR-4722-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.199275
QF-00-NO42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245236
GTEX-NPJ8-0011-R5a-SM-2HMJY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981278
Perturb_11424_KD_KIF4A_SRP324259	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.57408
primary motor cortex (area M1, area 4)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.980571
GSE219195_0_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03475
YY1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ID-70-SM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242848
skin rash	HPO Gene-Disease Associations	1.0	null
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85926
FD-25-KX07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.927736
CAL12T	CCLE Cell Line Gene Expression Profiles	1.0	1.5809
GTEX-TMMY-2226-SM-4DXTN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999321
lateral subdivision of area 9	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.07134
abnormality of cation homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.152351
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05178
Perturb_358_KD_SIRT5_SRP311327	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.54141
HE-10-QN66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.31773
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LAMA-84	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.0942
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormality of connective tissue	HPO Gene-Disease Associations	1.0	null
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-OOBK-0425-SM-3LK5O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949249
GTEX-WHSB-0326-SM-3LK6K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93002
Lung adenocarcinoma_LUAD_TCGA-50-6595-01A-12R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUGC3	CCLE Cell Line Gene CNV Profiles	1.0	1.47886
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.93
PMC6347712-pnas.1812449116.sd06.xlsx-iPSC_IRF7_48h_rest_RNAExpress-Gene_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8403
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.6985
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of r10BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18227
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A6RX-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.995406
PMC12629827-mmc8.xlsx-DDR2_KD-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
OE21	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.88996
496100551_PCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.38021
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
mantle zone of r8BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11515
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09921
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.72484
GSE249098_1_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE121198,GSE129782_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137902
1min_EGF vs ctrl_HeLa (Human) [17081983]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14287
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25856
spleen	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.73108
glycine-tRNA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.804
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.45287
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52493
Lung squamous cell carcinoma_LUSC_TCGA-22-5482-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
decreased CD8-positive, alpha-beta T cell number	MGI Mouse Phenotype Associations 2023	1.0	null
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.925948
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
RNASEH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49824
decreased marginal zone B cell number	MGI Mouse Phenotype Associations 2023	1.0	null
mantle zone of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04984
JHU029	DepMap CRISPR Gene Dependency	1.0	3.91954
GSE193993_1_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE239844_7_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126017
OVTOKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.96655
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.42
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.43573
ATF3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the lung	HPO Gene-Disease Associations	1.0	null
MCF7_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013996
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDVN-2326-SM-2S1PF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33257
H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15391_KD_CHD6_SRP399677	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.38091
PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Anterior olfactory nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.49549
RNF2	ENCODE Transcription Factor Targets	1.0	null
GSE169205_0_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865879
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182179_2_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perivascular astrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.379
GTF3C2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Costunolide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00933443
PMC6347712-pnas.1812449116.sd05.xlsx-iPSC_IRF7_48h_RNAExpress-Gene_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QMRM-0626-SM-447BQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17014
RNF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929743
GTEX-S95S-0226-SM-4B656	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32711
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23271
GSE202434,GSE202438_9_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary T cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.1087
BCL11A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Field CA1, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33902
SOX9-26525672-CHIP-SEQ-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-EGR1_DC_ChIP-seq_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
AA-85-LB25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.42916
Connective tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_11389_KD_BRG1_SRP261084	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.13184
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HASPIN	Kinase Library Serine Threonine Kinome Atlas	1.0	null
Status epilepticus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.235
DAUDI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYB_02_24	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60466
Riluzole hydrochloride_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0246367
Perturb_13830_KO_ZC4H2_SRP386383	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.2416
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
voltage-gated calcium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.296
r3 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85474
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-BatSRBD_12Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.58313
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
agammaglobulinemia	HPO Gene-Disease Associations	1.0	null
SKNSH	DepMap CRISPR Gene Dependency	1.0	2.98001
arthritis	HPO Gene-Disease Associations	1.0	null
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.08122
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.668028
POLR2A_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.29616
JUN_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.48093
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
KO52	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45714
NOS1	DepMap CRISPR Gene Dependency	1.0	2.54483
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.80749
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13321
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147328
GTEX-WFG7-2326-SM-3GIKV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74086
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.874063
Warts	DisGeNET Gene-Disease Associations	1.0	null
Trypomastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.569
GSE57871_5_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
light-harvesting complex, peripheral complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.675
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20327
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.68081
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.62704
decreased body weight	MGI Mouse Phenotype Associations 2023	1.0	null
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.578473
Diabetic Neuropathy_Sciatic Nerve_GSE11343	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.1495
GTEX-OHPM-0526-SM-2YUMJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59921
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.553809
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.16236
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.388
Aorta endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.801
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.12669
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-4456	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Lung adenocarcinoma_LUAD_TCGA-64-5815-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CHD2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TEAD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DC-23-UM36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344344
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
mRNA_SOX9_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
superficial stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.92796
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61001
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.382
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.55658
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.997103
CC-55-CD84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.487139
GTEX-QDVJ-0926-SM-2I5FU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10163
primary motor-sensory cortex (samples)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22195
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y7-01A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SETDB1-19884257-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
chloride transmembrane transport	GO Biological Process Annotations 2025	1.0	null
GTEX-RU72-1326-SM-2TF6T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942798
EC-82-LV30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.80353
GSE227698_5_v_0_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Entorhinal area, lateral part, layer 2a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27763
biological regulation	GO Biological Process Annotations 2015	1.0	null
H3K4me3_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Miscellaneous transport and binding events	Reactome Pathways 2024	1.0	null
dramatically	GeneRIF Biological Term Annotations	1.0	null
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30222
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.52838
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Toxic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.376
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.944227
intracellular glucose homeostasis	GO Biological Process Annotations 2025	1.0	null
ED-71-GA72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.43104
hsa-miR-499-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0706
K562_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166361
FLI1	ChEA Transcription Factor Targets	1.0	null
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE76425_1_v_10_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
leukocyte activation	GO Biological Process Annotations 2015	1.0	null
GSE111247_0_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Glucose intolerance	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.19
Primary visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69958
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23162
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_3533_OE_HLAG_SRP386253	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE48812_4_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
head of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.982877
r5 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03457
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VP-A875-01A-31R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
GSE156708_1_v_0_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prediabetes syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.299
GR-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.850939
PMC9314667-Table_1.xlsx-Regulons-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3672	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
nrf1_22586274_liver_lof_mouse_gpl4134_gse35124	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.184511
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17565
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
PMC11309649-medi-103-e37185-s002.xlsx-Sheet1-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
SRY	ChEA Transcription Factor Targets	1.0	null
GE-98-ZI68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212592
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.726
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051638
LRP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18157
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.99561
Hypogammaglobulinemia	DisGeNET Gene-Disease Associations	1.0	null
positive regulation of myoblast differentiation	GO Biological Process Annotations 2023	1.0	null
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.76909
dorsolateral prefrontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.60884
hsa-miR-4711-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48811
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.995578
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
External carotid artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.74
Brain Lower Grade Glioma_LGG_TCGA-DU-6393-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80515
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.729
medial trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.43756
GTEX-S4Q7-0626-SM-4AD5M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930932
papilloma	HPO Gene-Disease Associations	1.0	null
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYC_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30844
PMC4123081__F4	PFOCR Pathway Figure Associations 2024	1.0	null
METTL7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24994
Colorectaladenocarcinoma	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.967516
GSE145639_1_v_4_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.873361
LOUCY	CCLE Cell Line Gene CNV Profiles	-1.0	-2.44706
TAF1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
RCOR1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.42017
hsa-miR-323b-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
Membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NR2F2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3380-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Glucocorticoid receptor pathway	WikiPathways Pathways 2024	1.0	null
GTEX-Q2AH-0826-SM-48TZN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865321
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
USF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PQ-0426-SM-3NMCI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21996
SNU-C2B	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.01434
Macroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.192
KLF15_KO_GDS4780_419_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Vitelliform macular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.806
MY-M12	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-4.50556
immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.178403
GSE48812_4_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.912409
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDVN-0226-SM-48TZ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68064
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.028097
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
KDM5B	ENCODE Transcription Factor Targets	1.0	null
FOXP1-21924763-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
6863_PSMC6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20914
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78074
abnormal location of ears	HPO Gene-Disease Associations	1.0	null
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30037
posteroventral (inferior) parietal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.935044
PMC5771393-ACEL-17-na-s003.xlsx-FOXO1_Correlation_Pos-HUGO_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-568	TargetScan Predicted Conserved microRNA Targets	1.0	0.140752
ursodeoxycholic acid_mus musculus_gpl6246_gse22608	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_12229_KD_WTAP_SRP197044	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.71541
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PATU8988T	DepMap CRISPR Gene Dependency	1.0	2.43507
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_TGX-221_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169414
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CW-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.903422
CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_K562_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.12357
SIHA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XV7Q-2426-SM-4BRV8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3627
STK33	Kinase Library Serine Threonine Kinome Atlas	1.0	null
layer IIIu of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.928177
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.36625
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CREB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_3_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.36182
GSE216352,GSE216354_1_v_0_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
USF2_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
decreased DN2 thymocyte number	MGI Mouse Phenotype Associations 2023	1.0	null
SK-MEL-30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.850576
Sarcoma_SARC_TCGA-HS-A5N7-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.38468
Sepsis	DisGeNET Gene-Disease Associations	1.0	null
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256532
Nucleus ambiguus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29236
NANOG	ENCODE Transcription Factor Targets	1.0	null
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.425
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.85637
Lytic vacuole membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
IDH3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69418
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259897
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07353
Facial motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21468
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875434
r3 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.77569
RH18	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58739
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
monoatomic anion channel activity	GO Molecular Function Annotations 2025	1.0	null
PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4152
hilus of the DG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34212
waved hair	MGI Mouse Phenotype Associations 2023	1.0	null
mode of inheritance	HPO Gene-Disease Associations	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
cyclic-GMP-AMP transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML2-OVERLAP_GENES_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QH-01A-21R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.97769
SFTPC_KO_GSE35989_48_mouse_lung (type II cells)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
JF-96-HH81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.623997
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.487
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
TYK2_knockdown_176_GSE44652	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.65338
A549_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013068
GSE103122_0_v_1_riok3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3192	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GTF2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-1326-SM-4BOPV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01669
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94213
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPD	ENCODE Transcription Factor Targets	1.0	null
FOXP3-21729870-TREG-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
SREBP2-21459322-LIVER-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE133764_2_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleus of the diagonal band, left, horizontal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.72381
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H322M	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.51248
GTEX-RWSA-0926-SM-47JXW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10057
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92028
K562_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022915
GD-51-SU60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.72345
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.944629
RAD21_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Q7-1326-SM-4AD74	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71438
GSE230744,GSE237803_5_v_2_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100500_PCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15149
TFAP2C	ChEA Transcription Factor Targets	1.0	null
SIX5	ENCODE Transcription Factor Targets	1.0	null
Primary somatosensory area, trunk, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67927
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BCL3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE128730_0_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
USF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Aorta smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4993-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FB-95-JD99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.322186
primary motor cortex (area M1, area 4)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.31257
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4363
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-5319-01A-01R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the abdominal organs	HPO Gene-Disease Associations	1.0	null
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
positive regulation of insulin secretion	GO Biological Process Annotations 2025	1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.3487
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Osteomyelitis	DisGeNET Gene-Disease Associations	1.0	null
edema	IMPC Knockout Mouse Phenotypes	1.0	null
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.5161
orbital frontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15977
paravermis of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17394
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of myoblast differentiation	GO Biological Process Annotations 2025	1.0	null
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATF3-23680149-GBM1-GSC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU1J-1926-SM-2TF6S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0794
PMC2694838-1471-2164-10-241-S2.xls-Sheet1-Regulated_genes_by_ZNF191_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
ELF1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N6-A4V9-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.1777
GTEX-V1D1-2426-SM-3GAER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22643
decreased double-positive T cell number	MGI Mouse Phenotype Associations 2023	1.0	null
Posterior lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.692
Lung adenocarcinoma_LUAD_TCGA-55-6984-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5044-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.065
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964103
Primary somatosensory area, upper limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02105
plasma	GeneRIF Biological Term Annotations	1.0	null
chloride transport	GO Biological Process Annotations 2023	1.0	null
A549_Decitabine_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0102057
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BCLAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
thymus hypoplasia	MGI Mouse Phenotype Associations 2023	1.0	null
inorganic anion transmembrane transport	GO Biological Process Annotations 2025	1.0	null
GSE202434,GSE202438_8_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE215086_0_v_1_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182179_5_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PrPC_KO_GDS4352_358_mouse_Developing hippocampus from FVB newborns (4.5-day-old)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Entorhinal area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16419
NOMO1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47873
HB-92-XE24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.64932
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H4K20me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE165636_0_v_4_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-DX-A6BA-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DT-40 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.557
SKMEL1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57743
MIN-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.722
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.519
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M8-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NFK9-0526-SM-2YUNL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42067
hippocampus (hippocampal formation)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.967186
UWB1289	DepMap CRISPR Gene Dependency	1.0	2.59035
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.916277
7607_RUVBL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.737037
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.22412
GSE210373_0_v_1_cntnap4_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.60053
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-5565-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051724
TGFB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62907
glucose homeostasis	GO Biological Process Annotations 2023	1.0	null
UAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08241
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of skin physiology	HPO Gene-Disease Associations	1.0	null
medial preoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.959546
anion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
lymphnode_4a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.844459
COR-L26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.73152
hsa-miR-4656	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE128730_7_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
UBTF	ENCODE Transcription Factor Targets	1.0	null
Linear nucleus of the medulla	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60948
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08033
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cellular homeostasis	GO Biological Process Annotations 2015	1.0	null
RKO-E6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17824
estradiol_homo sapiens_gpl570_gse16683	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
496100555_TCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.11991
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cytoplasmic vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.906
RCOR1-19997604-NEURONS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4W-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4314	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
superficial stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04668
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MITF	ChEA Transcription Factor Targets	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-68-7755-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967418
H-69AR cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.069
GTEX-QVJO-0126-SM-3GIK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04963
SD-69-QA40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250874
SAP30	ENCODE Transcription Factor Targets	1.0	null
CTCF_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TP63_01_327	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.62433
GTEX-S3XE-0226-SM-4AD6I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962788
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
locus ceruleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.49859
intracellular glucose homeostasis	GO Biological Process Annotations 2023	1.0	null
PMC7617064-EMS151900-supplement-Extended_Data_Figure_7_Source_Data.xlsx-D23_NFIX-Logfold_change_threshold_1_0_1_NFIX	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.350091
A549_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149471
Autoimmune hemolytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
mantle zone of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3152
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.692
Steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.091
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
MAZ	ENCODE Transcription Factor Targets	1.0	null
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.366024
Autoimmune disease of the nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
Agammaglobulinemia	DisGeNET Gene-Disease Associations	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5KY-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-5394-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBTF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78051
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EK-01A-12R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreas	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929765
VA-06-DB75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211492
Stria vascularis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.739
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
periventricular stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85364
SR786	CCLE Cell Line Gene Expression Profiles	-1.0	-1.924
JUN-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE77108_8_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE128730_0_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
substrate-specific transporter activity	GO Molecular Function Annotations 2015	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.62485
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWN1-0626-SM-48TDT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944396
GSE118816_2_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	1.0	null
1935_CTNNA1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.523063
WC-33-YP46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.387517
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Foxn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.9981
SRF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SJXC-0526-SM-2XCFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75197
HTC-C3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3591-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.09606
intermediate stratum of DG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34421
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
posteroventral (inferior) parietal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.6079
SIN3B	ChEA Transcription Factor Targets	1.0	null
GSE154577_13_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SMARCA4_02_47	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60565
regulation of insulin secretion	GO Biological Process Annotations 2025	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5263-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GSE146982_7_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235066_4_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03364
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
verrucae	HPO Gene-Disease Associations	1.0	null
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182179_0_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.912359
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE254649_3_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Oculodentodigital dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
AA-88-PJ86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223191
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.06818
increased IgG2a level	MGI Mouse Phenotype Associations 2023	1.0	null
GSE239844_1_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Anterior olfactory nucleus, external part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42193
cell surface	GO Cellular Component Annotations 2015	1.0	null
neoplasm	HPO Gene-Disease Associations	1.0	null
enlarged lung	MGI Mouse Phenotype Associations 2023	1.0	null
AB-30-CR11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.662131
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03475
STAT1	ENCODE Transcription Factor Targets	1.0	null
GTEX-UTHO-0726-SM-3GAEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.935879
GSE135244_0_v_1_trdmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
RD-92-QT24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260111
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-7030-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1793	CCLE Cell Line Gene Expression Profiles	1.0	1.44922
Ventral posterolateral nucleus of the thalamus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16974
Eye disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.519
Lung squamous cell carcinoma_LUSC_TCGA-77-8144-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.42105
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SRF	ENCODE Transcription Factor Targets	1.0	null
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
FD-62-ZB67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.430848
uterine cervix	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
QE-18-WG07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276986
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
GSE202434,GSE202438_4_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6356-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic alpha cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.159
MCF7_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142188
BCL3-23251550-MUSCLE-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4379
ETV1_01_161	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.1
Pancreatic islet cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.808
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YV-1026-SM-3LK72	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897955
superficial stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71107
ELF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
AF-30-GH67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.518882
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.361901
GSE205163,GSE205164_5_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05127
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824505
GATA3	JASPAR Predicted Transcription Factor Targets	1.0	null
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
abnormality of the gastrointestinal tract	HPO Gene-Disease Associations	1.0	null
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TRPM7_defectivemutant_306_GSE23102	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.58896
GSE116492,GSE116495_3_v_2_stag2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.5435
Perturb_12078_KO_Ezh1_SRP060232	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.16796
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.42042
GSE224311_3_v_0_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BICR18	CCLE Cell Line Gene Expression Profiles	1.0	2.40535
CDK8_knockdown_63_GSE19199	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.37948
BICR22	CCLE Cell Line Gene CNV Profiles	1.0	1.59429
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.50483
CADO-ES1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abnormality of humoral immunity	HPO Gene-Disease Associations	1.0	null
Gap junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.218
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24044
ATF2	MotifMap Predicted Transcription Factor Targets	1.0	null
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_proteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Hyperplasia	CTD Gene-Disease Associations	1.0	1.27626
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918831
BE-27-RQ61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29356
ATF1	MotifMap Predicted Transcription Factor Targets	1.0	null
AA-22-PQ14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249987
SKMEL24	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39605
VMRCRCZ	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62045
GSE158834_0_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.888791
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.864619
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.9696
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.27867
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31023
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RERF-LC-SQ1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
arcuate nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04674
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.41435
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOSL2	ENCODE Transcription Factor Targets	1.0	null
substrate-specific transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-PLZ5-0726-SM-2I5F9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962961
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59315
FLI1_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lymph node	HPA Tissue Protein Expression Profiles	-1.0	-1.76164
Vascular smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.686
Neuroendocrine tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.809
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4908-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE154577_7_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H2373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21097
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKMEL5_SKIN	CCLE Cell Line Proteomics	1.0	2.23936
GSE146982_0_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_8_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
Penfluridol_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0353854
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
head of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08308
GTEX-UTHO-2926-SM-3P5Z9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872103
Pulmonary artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.227
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DL-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A7WH-01A-22R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AH-0626-SM-48TZJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08158
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114883_0_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_1_ZZZ3_ChIP-seq_peaks-Genebody_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.31678
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14453
superficial dorsofrontal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54305
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
abnormality of the integument	HPO Gene-Disease Associations	1.0	null
hsa-miR-3680	TargetScan Predicted Conserved microRNA Targets	1.0	0.03694
Insulinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.979
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.96957
A549_S-Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153864
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EOMES	ChEA Transcription Factor Targets	1.0	null
EP300_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-129-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
planum polare, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.899138
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882133
SP in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40983
GTEX-XOTO-2126-SM-4B64U	GTEx Tissue Sample Gene Expression Profiles	1.0	2.23475
AC-31-PL89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.805851
mantle zone of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08853
FARAGE	DepMap CRISPR Gene Dependency	1.0	2.26031
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5553-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormality of head or neck	HPO Gene-Disease Associations	1.0	null
OVOL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0112
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
deltaEF1	MotifMap Predicted Transcription Factor Targets	1.0	null
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38321
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.519
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A2QG-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
venetoclax_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.017618
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ChIP_TCFCP2L1_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
ion channel activity	GO Molecular Function Annotations 2015	1.0	null
disruption	GeneRIF Biological Term Annotations	1.0	null
Perturb_11426_KD_PRMT1_SRP357238	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.94578
oculomotor nuclear complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.896969
single-organism localization	GO Biological Process Annotations 2015	1.0	null
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.82203
decreased transitional stage B cell number	MGI Mouse Phenotype Associations 2023	1.0	null
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.08196
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE157635_1_v_0_trem2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.442875
Glia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.174
EJM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
abnormal T cell selection	MGI Mouse Phenotype Associations 2023	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4583-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC4686761-ncomms10068-s3.xlsx-S2E-MSC_up_specific-Supplementary_Data_2E_-_expression_of_up-regulated_genes_2_fold_change_specifically_in_MSC_PTEN-_-_vs_MSC_PTEN_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4448	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
voltage-gated potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.786
HT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
lateral (dentate) cerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57404
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
STAT3-29892750-EML-MOUSE-BONEMARROW	ChEA Transcription Factor Targets 2022	1.0	null
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
respiratory tract infection	HPO Gene-Disease Associations	1.0	null
sinusitis	HPO Gene-Disease Associations	1.0	null
GAL3ST3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77787
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE114883_0_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144827
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
open-angle glaucoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.519
PMC10940914-mmc4.docx-0-PRDM16_PRDM16	Rummagene Transcription Factor Associations 2026	1.0	null
UBE2T	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53246
GTEX-X261-1026-SM-3NMDL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40755
HT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC7429792-40104_2020_487_MOESM3_ESM.xlsx-MSC_enriched_miRNA_target-NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
S0-EE-Y9JI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.291116
hsa-miR-4667-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100323_FWM_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.70917
GTEX-WHWD-2426-SM-3LK6S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893861
Macula densa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.709
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7430-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Betamethasone dipropionate_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00842487
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.401765
abnormal eye morphology	MGI Mouse Phenotype Associations 2023	1.0	null
Perturb_559_OE_NUP98HOXA10_SRP158432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.61133
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46436
anterodorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10303
GTEX-SNOS-0626-SM-4DM5F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1204
MCF7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905434
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
r7 part of the basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07398
GTEX-U3ZN-0926-SM-4DXTU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09772
BHY	CCLE Cell Line Gene Expression Profiles	1.0	1.67881
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.13911
basal nucleus of meynert, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01305
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.43446
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0353
increased thymocyte apoptosis	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-OHPL-3026-SM-3MJGS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24357
GATA2	ChEA Transcription Factor Targets	1.0	null
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282373
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cpae	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.801
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE209582_1_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
DLX5_OE_GDS4577_345_mouse_Otic vesicle derived 2B1 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
hsa-miR-4675	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Hippocampal region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13871
GTEX-S3XE-0326-SM-4AD6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.431
GTEX-XPVG-2926-SM-4B66G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20609
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83672
NCIH1581_LUNG	CCLE Cell Line Proteomics	1.0	4.18893
MYC_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HB-92-XE24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27366
immature B cell differentiation	GO Biological Process Annotations 2023	1.0	null
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.927559
A549_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174936
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JEKO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.11637
dorsolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.824686
AP-4	MotifMap Predicted Transcription Factor Targets	1.0	null
Perturb_7351_KD_SFPQ_SRP281189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.99345
mantle zone of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.01679
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97678
ARID3A	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-374c	TargetScan Predicted Conserved microRNA Targets	1.0	0.082179
PMC12729234-10194_2025_2222_MOESM1_ESM.xlsx-Table_S6-Table_S6_MR_results_of_the_significant_genes_from_human_brain_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Subiculum, ventral part, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31041
abnormality of transition element cation homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.224076
Perturb_2164_KD_Chd8_SRP062904	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.574
Gnathodiaphyseal dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HNF4G	ENCODE Transcription Factor Targets	1.0	null
GTEX-NFK9-1326-SM-3LK5I	GTEx Tissue Sample Gene Expression Profiles	1.0	2.29163
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.873792
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23974
Body Height	DisGeNET Gene-Phenotype Associations	1.0	null
layer 5 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25116
RFX5	ENCODE Transcription Factor Targets	1.0	null
GSE189859,GSE189861_4_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326175
single-organism transport	GO Biological Process Annotations 2015	1.0	null
B875 antenna complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.784
r8 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2486
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
monoatomic anion transport	GO Biological Process Annotations 2025	1.0	null
channel activity	GO Molecular Function Annotations 2015	1.0	null
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
YY1_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
breast	HPA Tissue Protein Expression Profiles	-1.0	-1.30178
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A114-11A-12R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041155
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38923
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT2_02_18	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59749
MYC_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.69086
Syntrophin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.177
central gray substance of midbrain, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.94116
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-A75K-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964755
H3K79me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BA-68-FJ41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202783
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.880238
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_231_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Anteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44797
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-203-ZNF79_ZNF79	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2ES-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15685_KO_Stat1_SRP277338	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26829
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896714
osteomyelitis	HPO Gene-Disease Associations	1.0	null
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8728_KD_ZNF414_SRP269946	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.969987
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.222
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Focal epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BE-92-TW08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298594
AZD-7648_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.013117
DF-93-BT88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.60382
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-96-HO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215396
small intestine	HPA Tissue Protein Expression Profiles	1.0	1.99325
Pancreatic islet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.796
PMC11684804-jci-135-174981-s193.xlsx-DESeq2_pseudobulk_AA_Ag_vs_Pre-Gene_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
r5 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03726
EOMES-20176728-TSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DC-51-WE27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.433515
OCI-AML5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.23162
ED-87-UE76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213848
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76828
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
GSE143692_2_v_3_trim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
cyclic-GMP-AMP transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE133087_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PANC 03.27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.854454
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LB-11A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_4_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CMAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97774
YY1_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216043_10_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Large granular lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.35
HC-09-KP12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222941
posterior (caudal) superior temporal cortex (area 22c)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.838113
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TASK1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP4	ENCODE Transcription Factor Targets	1.0	null
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0977
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-A5EL-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54018
hsa-miR-641	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07569
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.752056
VA-06-DB75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.67407
GTEX-PWCY-2226-SM-2S1OP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44155
ChIP_SETDB1_19884257	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
TRMT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34607
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246099
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.043366
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE229973_4_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R55G-0626-SM-48FDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43259
GTEX-QCQG-1926-SM-2S1PI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14266
GTEX-PSDG-1026-SM-48TCV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20496
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-7332-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7827_SET_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.81162
HOXB4-20404135-EML-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-U3ZN-1626-SM-4DXTZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943092
E2F6_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thp1	HPA Cell Line Gene Expression Profiles	-1.0	-1.28128
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.845496
abnormality of the eye	HPO Gene-Disease Associations	1.0	null
Null cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.35
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-0626-SM-4DXT3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987749
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.84051
KLF15_KO_GDS4780_509_mouse_heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.22053
GTEX-XBED-0726-SM-4GIAR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07879
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22431
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PRDM1	ENCODE Transcription Factor Targets	1.0	null
abnormality of the periorbital region	HPO Gene-Disease Associations	1.0	null
external part of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42514
Rectum adenocarcinoma_READ_TCGA-DT-5265-01A-21R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Weight Loss	CTD Gene-Disease Associations	1.0	1.10527
ERMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79561
FA-80-DR66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290317
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896714
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.405
Glaucoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
r8 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12709
RC-K8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6881
RAB10	MSigDB Cancer Gene Co-expression Modules	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r8BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44623
M14	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abnormality of the ear	HPO Gene-Disease Associations	1.0	null
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11756
monoatomic anion transport	GO Biological Process Annotations 2023	1.0	null
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the outer ear	HPO Gene-Disease Associations	1.0	null
GSE144484_2_v_1_mllt6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7832-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
esophagus_5b	HPA Tissue Sample Gene Expression Profiles	1.0	0.909491
inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.992632
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.095
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.491
A549_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142775
GTEX-S4Z8-0626-SM-4AD6J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15481
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03442
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.15552
RH30	DepMap CRISPR Gene Dependency	1.0	3.17942
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.862827
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385494
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CJM	CCLE Cell Line Gene Expression Profiles	1.0	1.61348
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899461
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169205_3_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A66Y-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.752
Fetal_Intestine_Large	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.912324
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02275
inflammatory abnormality of the skin	HPO Gene-Disease Associations	1.0	null
HS 255.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.55489
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thorax	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07549
Dentate gyrus, polymorph layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57455
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.993661
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2J2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.507
abnormal renal tubule morphology	MGI Mouse Phenotype Associations 2023	1.0	null
PMC7316257-pone.0233899.s011.xlsx-AR_regulated_genes-genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X8HC-0526-SM-4E3JA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878515
Intercalated cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.193
Thyroid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.54316
GTEX-XYKS-0426-SM-4BRW4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12688
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
purine ribonucleotide transport	GO Biological Process Annotations 2023	1.0	null
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KAT2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0094358
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905529
Perturb_4180_KO_Tsc1_SRP279018	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.20231
ventrolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09887
homeostatic process	GO Biological Process Annotations 2015	1.0	null
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9928584-41556_2022_1059_MOESM3_ESM.xlsx-Table_8-Supplementary_Table_8_ETV6-repressed_genes_defined_by_dTAG_at_72_hours_ETV6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.91465
Reticulum trabeculare	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.647
Pseudopalisading cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.851
EF-85-DA07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230666
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.95393
GTEX-P4QS-1826-SM-2S1NI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28292
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3461-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EE-01-FB85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217755
ELK1	ENCODE Transcription Factor Targets	1.0	null
21205295-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-OHPL-0426-SM-3TW8X	GTEx Tissue Sample Gene Expression Profiles	1.0	2.65974
abnormality of the nervous system	HPO Gene-Disease Associations	1.0	null
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
five	GeneRIF Biological Term Annotations	1.0	null
GR-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
recurrent respiratory infections	HPO Gene-Disease Associations	1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.325
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GATA3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_1027_KO_Ovgp1_SRP379795	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.0772
AU565_BREAST	CCLE Cell Line Proteomics	1.0	3.18546
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
epicanthus	HPO Gene-Disease Associations	1.0	null
abnormality of fluid regulation	HPO Gene-Disease Associations	1.0	null
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.826678
SIN3A_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sensory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.519
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.55466
MCF7_Epothilone A_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012716
RAD21_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5844-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA1	ENCODE Transcription Factor Targets	1.0	null
A549_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015464
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.14919
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01907
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A5XV-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PSDG-1126-SM-2S1ON	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954551
GSE48812_7_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lrrc5	GeneRIF Biological Term Annotations	1.0	null
BARX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11782
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08883
GSE48812_11_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hypertelorism	HPO Gene-Disease Associations	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
response to stress	GO Biological Process Annotations 2015	1.0	null
ablated	GeneRIF Biological Term Annotations	1.0	null
Eye-conjunctival epithelial cell	Tabula Sapiens Gene-Cell Associations	1.0	5.09923
QA-34-PH05_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.469564
Prostate adenocarcinoma_PRAD_TCGA-HC-8262-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.17592
GTEX-XQ3S-0126-SM-4BOO9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900417
dystrophin-associated glycoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.07
MCF7_Meprednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152712
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SF-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.25
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.53805
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225323
BB-42-FF52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316173
FD-59-TC81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.92266
primary somatosensory cortex (area S1, areas 3,1,2)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.874057
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61475
PPARD	ChEA Transcription Factor Targets	1.0	null
GSE146982_3_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206516,GSE206518_0_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04396
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE200839,GSE233826_5_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2934
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.83133
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.416148
granule cell layer of the DG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.82746
KE39	CCLE Cell Line Gene CNV Profiles	1.0	1.39681
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03681
hsa-miR-141	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956263
intermediate stratum of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00766
GSE230174_0_v_1_dagla_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.883098
GTEX-RM2N-1826-SM-2TF5B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11178
lung	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053015
JUN_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999117
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.999676
Clopidogrel_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0171178
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.52126
abnormality of facial skeleton	HPO Gene-Disease Associations	1.0	null
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YV-1626-SM-2YUNJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42614
BB-20-UU03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.708236
BxPC-3	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.69719
BC-00-YH62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.776788
DSTYK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05129
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.44335
PMC5651844-41467_2017_1173_MOESM10_ESM.xlsx-ZZZ3_occupied_genes-Supplementary_Data_7_ZZZ3_occupied_genes_and_overlaps_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
Leucine-rich repeat-containing protein 8, N-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
GSE197555_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cortical collecting duct cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.501
SALE	CCLE Cell Line Gene Expression Profiles	1.0	3.25052
GTEX-XPT6-2226-SM-4B66R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.995543
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.971645
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3N6-01A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tongue epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.068
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
USF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE244710_3_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCC13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EGR1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal embryo size	MGI Mouse Phenotype Associations 2023	1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26734
Macropinosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.368
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-EU-5904-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
monoatomic ion channel activity	GO Molecular Function Annotations 2023	1.0	null
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946742
protein hexamerization	GO Biological Process Annotations 2025	1.0	null
GTEX-TMMY-1026-SM-4DXTI	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02094
GSE169356_0_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebellar nuclei of CbH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01303
NCI-H508	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
anion transport	GO Biological Process Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3454-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21767
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.895187
GSE57871_5_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18734
VDR-24763502-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NCIH1876	CCLE Cell Line Gene CNV Profiles	1.0	2.09041
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052428
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10058
496100336_TCx_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.27901
GB-64-HC34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.317878
SNU349	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45741
GSE202434,GSE202438_8_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.62697
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE158834_0_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
EM2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54291
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
chloride transport	GO Biological Process Annotations 2025	1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3764_KD_CHD7_SRP352803	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.74966
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8858874-NIHMS1764275-supplement-Supplemental_Table_2.xlsx-R1_SOX2_bound_genes_5000bp_6-9--Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
BXPC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.28572
AD-18-XC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293611
GSE189609_1_v_0_hax1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE219195_4_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
JUND_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.892925
EC-60-CX20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243977
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22993
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Basal ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.124
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r1 part of vestibulocerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39692
ME1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.7071
layer 3 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01338
PMC12703482-AMS-21-5-213605-s2.xlsx-Supplementary_Table_SXVII-SMR_results_of_expression_levels_of_VDR_target_genes_in_peripheral_blood_and_risk_of_sarcoma_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
thymocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.281776
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.5392
decreased immature B cell number	MGI Mouse Phenotype Associations 2023	1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
glis2_17618285_kidney_lof_mouse_gpl2897_gds2817	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.106
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8701
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_4_Overlap_of_ERM_proteom-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13045
Eye-radial glial cell	Tabula Sapiens Gene-Cell Associations	1.0	1.16192
r6 part of rostral ventromedial reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2008
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SN-01A-12R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.816753
AU565	DepMap CRISPR Gene Dependency	1.0	2.1168
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r9 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50427
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.43993
t-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.114463
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.506581
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fields of Forel	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74223
OSTM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20121
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4072
transporter activity	GO Molecular Function Annotations 2015	1.0	null
Mesothelioma_MESO_TCGA-NQ-A57I-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG5-1226-SM-447AR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51281
Lung squamous cell carcinoma_LUSC_TCGA-60-2707-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-51-4081-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45801
GTEX-T5JC-0226-SM-32PMA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46456
IRF1	ENCODE Transcription Factor Targets	1.0	null
SIN3A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5291205-srep41905-s3.xlsx-LPS_datasets_gmx-Unnamed_4_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_11445_KD_GATA2_SRP178865	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.72079
G-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
knockdown	GeneRIF Biological Term Annotations	1.0	null
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.911589
Endocrine pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.796
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL-12T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.39455
MCIXC	DepMap CRISPR Gene Dependency	1.0	3.36579
Fingolimod (hydrochloride)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0302334
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
cetuximab_homo sapiens_gpl570_gse21483	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC5651844-41467_2017_1173_MOESM7_ESM.xlsx-ZZZ3_ChIP-seq_peaks-Unnamed_6_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
response to abiotic stimulus	GO Biological Process Annotations 2015	1.0	null
JAK2_knockout_79_GSE26188	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.12569
PBX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mucous acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.593
A549_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223875
EF-61-NY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227544
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
20101236-SuppTable7b	GeneSigDB Published Gene Signatures	1.0	null
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
CREB1	ChEA Transcription Factor Targets	1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.860173
Ion channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.36
GTEX-NPJ8-0526-SM-3MJHN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07483
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.573686
LA-44-KW22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2739
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE114883_1_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Fever	DisGeNET Gene-Phenotype Associations	1.0	null
TD-09-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230041
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCL3-23251550-MUSCLE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ID-00-IC14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289304
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.584
6043_PAK1IP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.510208
Dentate gyrus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30335
SIX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_7_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A704	CCLE Cell Line Gene Expression Profiles	-1.0	-2.39791
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Thymus	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.25514
substantia nigra, compact part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12341
Adrenocortical carcinoma_ACC_TCGA-OR-A5J9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201270,GSE201272_5_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Fenofibrate_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0123199
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.76904
CORL24	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40195
NFYB	ENCODE Transcription Factor Targets	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34009
mantle zone of r10BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08923
GB-73-QS80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.378658
RKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17824
hsa-miR-4804-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
FOXA1_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2823_FAHD2B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.534934
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_1_BioID_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4719	TargetScan Predicted Conserved microRNA Targets	1.0	0.15008
GTEX-XV7Q-0526-SM-4BRWR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45432
abnormality of nervous system morphology	HPO Gene-Disease Associations	1.0	null
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.1411
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206565
PMC6436215-13073_2019_626_MOESM2_ESM.xlsx-PCM-NR1H2_NR1H2	Rummagene Transcription Factor Associations 2026	1.0	null
sodium:potassium-exchanging ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.399
H1_Cell_Line	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.854638
abnormality of the head	HPO Gene-Disease Associations	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928973
Acute Myeloid Leukemia_LAML_TCGA-AB-2846-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.252
GSE122425_1_v_0_nsun2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pancreatic duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.851
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
L-type voltage-gated calcium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.576
USF1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IB-33-TE51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203361
ETS1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pituicyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.179
HEK-293F cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.698
DAOY_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	2.18583
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187824
SNU489	CCLE Cell Line Gene CNV Profiles	1.0	1.37338
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.75235
Congenital Absence Of Germinal Epithelium Of Testes	DisGeNET Gene-Disease Associations	1.0	null
CREBBP	ENCODE Transcription Factor Targets	1.0	null
HF-91-IU60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.309281
BB-86-UL91_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.343591
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.32293
NCIH2126	DepMap CRISPR Gene Dependency	1.0	2.28448
cell differentiation	GO Biological Process Annotations 2015	1.0	null
CB-02-XL81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.401566
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
IZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07925
MYOG	ENCODE Transcription Factor Targets	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7890-01A-12R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r5BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24359
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7288-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE239844_6_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
layer 4 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55008
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887791
SRY-25088423-EMBRYONIC GONADS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
7393_RNF4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.65454
Subiculum, ventral part, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11536
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZEB1	ENCODE Transcription Factor Targets	1.0	null
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67956
Autoimmune disease of musculoskeletal system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
GTEX-SNOS-0426-SM-32PMH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04052
RNF130	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08505
Perturb_11433_KD_NKX25_SRP152523	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.60912
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70443
GTEX-Q2AH-0326-SM-48U1K	GTEx Tissue Sample Gene Expression Profiles	1.0	2.38897
DLGAP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44814
SRF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNF4A	ENCODE Transcription Factor Targets	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6146-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skin	HPA Tissue Protein Expression Profiles	-1.0	-1.46537
NEK1	Kinase Library Serine Threonine Kinome Atlas	1.0	null
cotransfection	GeneRIF Biological Term Annotations	1.0	null
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.01972
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43631
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OQ-01A-32R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE188382_4_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4433-01A-22R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
NE-34-OZ69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290472
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34517
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5ER-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HHV8_72Hour-BEC_20080955_GSE16354	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.7079
Nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.519
Roxadustat_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00992441
Vitamin D receptor pathway	WikiPathways Pathways 2024	1.0	null
MBD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6650964__F5a	PFOCR Pathway Figure Associations 2024	1.0	null
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17657
H3K79me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.73851
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.990239
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Granular lamina of the cochlear nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35346
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
PMC10834420-12276_2023_1140_MOESM2_ESM.xls-ST12-Unnamed_5_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
QA-34-PH05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.947184
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6795-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE174498,GSE174500_3_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ammon's horn	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06287
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUN-01A-12R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of the middle ear	HPO Gene-Disease Associations	1.0	null
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.9751
Cco	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.867
YY1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MA-58-RR04_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.437187
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03364
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.80169
Plasma membrane raft	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.622
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D4-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8HM-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormality of b cells	HPO Gene-Disease Associations	1.0	null
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GA-28-SS67_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.489979
HNF4A	ChEA Transcription Factor Targets	1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08971
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.444663
QA-34-PH05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.606776
Leukocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.35
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1919
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE139455_4_v_1_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.078
GTEX-OHPN-2726-SM-2I5H4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08441
Uterine Carcinosarcoma_UCS_TCGA-N8-A56S-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE144500_8_v_2_ventx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NKX2-5-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ion channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PMC6650964__F5a	PFOCR Pathway Figure Associations 2023	1.0	null
primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.768801
GTEX-O5YT-0426-SM-3MJHD	GTEx Tissue Sample Gene Expression Profiles	1.0	2.36727
hsa-let-7e-5p	MiRTarBase microRNA Targets	1.0	null
GA-10	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.66436
ARHGEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45699
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.884257
GTEX-VJYA-0726-SM-4KL1T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46846
SREBP2-21459322-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE235066_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-Normal_309_TCF7_rep1_sorted_pea-Gene_Name_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
ZR751	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.10698
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-GK-A6C7-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
carboxylic acid transmembrane transport	GO Biological Process Annotations 2025	1.0	null
H3K4me1_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.74756
Acute Myeloid Leukemia_LAML_TCGA-AB-2881-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE123734_1_v_0_mien1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7519331-pnas.1921408117.sd18.xlsx-ERM_OMM_DualBiotinylated_APEXSq-Ensembl_Gene_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50977
A10 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.579
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
WA-15-KX40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308585
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
SUDHL8	DepMap CRISPR Gene Dependency	1.0	3.34838
FOXA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14585
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
SRY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09315
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_Rectal Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
AURKA_druginhibition_196_GSE57810	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.68196
hsa-miR-191	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
HEK-293 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.725
Agammaglobulinemia, Non-Bruton Type	DisGeNET Gene-Disease Associations	1.0	null
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE207728,GSE207808_2_v_1_c646_human	RummaGEO Drug Perturbation Signatures	-1.0	null
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19523
T84	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PA-TU-8902	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09664
GSE80537_0_v_2_adhfe1_human	RummaGEO Gene Perturbation Signatures	1.0	null
lymphocyte differentiation	GO Biological Process Annotations 2015	1.0	null
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.27258
GSE162892_3_v_5_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5K8-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.6725
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.86126
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the sinuses	HPO Gene-Disease Associations	1.0	null
ZFAND2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88926
abnormal thymus morphology	MGI Mouse Phenotype Associations 2023	1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.982002
EGR1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abducens nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00807
Prostate adenocarcinoma_PRAD_TCGA-HC-A8CY-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216043_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4341-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DC-23-UM36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222133
absent thymus corticomedullary boundary	MGI Mouse Phenotype Associations 2023	1.0	null
PMC10534007-Table_2.xlsx-S5_unique_up_MSC_B-721_elements_included_exclusively_in_BFTC905_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Arteriosclerotic cardiovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
hsa-miR-1	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
purine ribonucleotide transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933173
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GD-46-BU97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344198
DA-10-GX45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256865
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
HAP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.019
inner CP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02111
17676974-TableS1	GeneSigDB Published Gene Signatures	1.0	null
SIX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
L-363	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-4.30043
GTEx Nerve 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-11.3256
TEX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99207
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32499
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135918
VMCUB1	CCLE Cell Line Gene Expression Profiles	1.0	2.5552
GSE154197_1_v_0_ints13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-206	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.82294
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE169205_4_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XV7Q-1126-SM-4BRVS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12329
Spleen	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.859751
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36574
LOX-IMVI cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.703
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Leucine rich repeat 4	InterPro Predicted Protein Domain Annotations	1.0	null
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
SIX5_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0844
SKES1_BONE	CCLE Cell Line Proteomics	1.0	2.11377
substantia nigra, pars compacta, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.90842
Brain Lower Grade Glioma_LGG_TCGA-HT-7684-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSC-39	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC1599	CCLE Cell Line Gene CNV Profiles	1.0	1.42418
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-2_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Collecting duct cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.883
oculomotor nuclear complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02711
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RE-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
midbrain reticular formation, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26437
r6 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12496
Sarcoma_SARC_TCGA-DX-A7EM-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JD-62-HR05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.926768
THAP1	ENCODE Transcription Factor Targets	1.0	null
17660535-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
GTEX-U3ZM-0526-SM-4DXTB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43316
POLR2A	ENCODE Transcription Factor Targets	1.0	null
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1c-List_of_1682_genes_differentially_regulated_by_GLI1_FDR_0_1_GLI1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KC-32-GO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23489
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09585
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
BACH1	ENCODE Transcription Factor Targets	1.0	null
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.286736
OVOL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.113
MOLM13	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59738
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KAT2A	ENCODE Transcription Factor Targets	1.0	null
K562_Trichostatin A_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183383
BD-90-DK64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.410758
hsa-miR-874	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
SNU-407	COSMIC Cell Line Gene Mutation Profiles	1.0	null
low-set ears	HPO Gene-Disease Associations	1.0	null
POLR2AphosphoS5_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SRY-25088423-EMBRYONIC-GONADS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79869
CTCF_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
ISHIKAWAHERAKLIO02ER_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	3.78073
Vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GABPA_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.023699
r9 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.83221
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2776
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6269
PMC12035534-gfae237_supplemental_file.pdf-64-RUNX1_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
OVSAHO_OVARY	CCLE Cell Line Proteomics	1.0	2.004
AD-00-WA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.416944
CREB3L4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8392
PMC11385326-joces-137-261952-TableS5.xlsx-AP2_possible_cargo-Gene_names_AP2_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
Glioblastoma multiforme cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.509
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.222
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.349
CB-24-AT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.971597
hsa-miR-486-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
SF268	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.567376
blood vessel	GTEx Tissue Gene Expression Profiles	1.0	1.45759
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47933
MAFF	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MU-A8JM-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5637904-PATH-243-193-s015.xlsx-human_down_in_ductal_SOX11-Table_S4C_Downregulated_genes_in_lesions_and_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_the_mammary_duct_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of the tracheobronchial system	HPO Gene-Disease Associations	1.0	null
AF-67-LZ82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.757896
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19372
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.53074
polymorphic layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.58155
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
ELF1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100324_FWM_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01948
496100407_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.41917
GSE235605,GSE235701_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.891937
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.846967
TAF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
decreased T cell number	MGI Mouse Phenotype Associations 2023	1.0	null
BE-27-RQ61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216409
pre-t-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.278955
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FLI1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29367
cyclic-GMP-AMP transmembrane import across plasma membrane	GO Biological Process Annotations 2023	1.0	null
A549_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216005
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.791747
Leydig cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.821
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9232687-13238_2021_887_MOESM3_ESM.xlsx-37_KD_sgCDC20_vs_sgNTC-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
thymic epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.71009
FLI1	MotifMap Predicted Transcription Factor Targets	1.0	null
abnormal B cell differentiation	MGI Mouse Phenotype Associations 2023	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-7711-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A23B-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205714
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE253795_1_v_0_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
hyperkeratosis	MGI Mouse Phenotype Associations 2023	1.0	null
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.591497
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01052
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of cell differentiation	GO Biological Process Annotations 2025	1.0	null
essential	GeneRIF Biological Term Annotations	1.0	null
RAP2A	MSigDB Cancer Gene Co-expression Modules	1.0	null
Escherichia coli infection of the central nervous system_CNS - Brain (MMHCC)_GSE3253	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.9422
Male Infertility	DisGeNET Gene-Phenotype Associations	1.0	null
PMC3680531-cc-12-1510-s01.pdf-20-ZNF655_ZNF655	Rummagene Transcription Factor Associations 2026	1.0	null
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.11081
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MT-0326-SM-48TDP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8805
Sarcoma_SARC_TCGA-DX-A3UB-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE57871_6_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Amino acid transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.79
Poisoning	CTD Gene-Disease Associations	1.0	1.32369
SMAD4	ChEA Transcription Factor Targets	1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BronchialEpithelialCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.24789
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PPM1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04639
HO-1-N-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EF-01-LB20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351311
SDHA	Pathway Commons Protein-Protein Interactions	1.0	null
CALU6	DepMap CRISPR Gene Dependency	1.0	4.73709
JURLMK1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.32097
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BCL3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
dorsolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.876616
GTEX-SSA3-0326-SM-32QPS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01552
SKMEL24	DepMap CRISPR Gene Dependency	1.0	10.3759
skin ulcer	HPO Gene-Disease Associations	1.0	null
GSE93124_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AIM2 inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.141
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_MYCN_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
piriform cortex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.888806
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GJA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06897
paraparesis	MGI Mouse Phenotype Associations 2023	1.0	null
T98G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896714
EM2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.92027
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955308
PMC9170756-mmc6.xlsx-P6-Table_S3_The_JUN-targeted_responders_to_FFA_treatments_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
DB-56-XL71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.497157
Early endosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.668
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LXR-22292898-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Malabsorption, Ctcae	DisGeNET Gene-Phenotype Associations	1.0	null
DA-66-OE69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225587
immune system process	GO Biological Process Annotations 2015	1.0	null
medial pallium (hippocampal allocortex)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12689
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.73037
Perturb_4260_OE_MEIS1_SRP201342	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.199
biological_process	GO Biological Process Annotations 2015	1.0	null
GSE235066_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NOL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2754
DE-52-BS63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265755
Silver ion transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.986
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1500	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.793366
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.07902
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
VDR-21846776-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.34301
MYCN-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
subpretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00347
r6 part of ventral gigangocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2479
BA-69-TQ80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.493737
Lung adenocarcinoma_LUAD_TCGA-49-6767-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.825073
H3K9ac_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A74L-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TP53-23651856-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FD-72-CE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259847
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCFCP2L1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE230174_0_v_1_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-3617	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
DOK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07755
hsa-miR-4292	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
GTEX-XUW1-0726-SM-4BOP5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.940934
hsa-miR-125b	TargetScan Predicted Conserved microRNA Targets	1.0	0.175726
ED-91-LY45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.558146
Upper respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
537 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32132
Inflammation	CTD Gene-Disease Associations	1.0	1.65314
GSE215086_1_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bestrophinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.902
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
response to osmotic stress	GO Biological Process Annotations 2015	1.0	null
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FLI1	ENCODE Transcription Factor Targets	1.0	null
pre-b cell differentiation	GO Biological Process Annotations 2015	1.0	null
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.130857
r7 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21073
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.53476
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Endoplasmic reticulum-Golgi intermediate compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.213
protein hexamerization	GO Biological Process Annotations 2023	1.0	null
HCT-116 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.606
GTEX-U3ZN-1726-SM-4DXUQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911552
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
integral component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.436565
Collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.26
Lytic vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Renal medulla cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.871
mantle zone of r7BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21788
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.3046
NCIH2030	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61409
GSE175787_13_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
mammarygland.lact.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.05452
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.965369
H3K4me1_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
protein-containing complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.35985
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.68
pretectal region	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.880779
MA-32-UX14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227872
KLF4	ChEA Transcription Factor Targets	1.0	null
AF-72-PP21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.545149
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.964821
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7919
Posterior parietal association areas, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63388
JUND_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Stinger	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.19
CD14+_Monocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.74769
17023574-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Amygdala	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.124
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.27093
sepsis	HPO Gene-Disease Associations	1.0	null
TEAD1	JASPAR Predicted Transcription Factor Targets	1.0	null
hsa-miR-4640-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
Fedratinib (hydrochloride hydrate)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0134207
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09648
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Esophagus - Gastroesophageal Junction	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.983421
CREB1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1	ENCODE Transcription Factor Targets	1.0	null
vrac	GeneRIF Biological Term Annotations	1.0	null
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20506
Perturb_13912_KD_TARDBP_SRP169127	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.79705
epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052137
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5B_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-CoV MA15_Day7-PFU-10^5_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.87745
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPM-0126-SM-2YUN9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92409
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06815
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.859174
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.05629
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CK-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chloride transmembrane transport	GO Biological Process Annotations 2023	1.0	null
ARHGDIA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21811
hsa-miR-335-5p	MiRTarBase microRNA Targets	1.0	null
GTEX-PX3G-1626-SM-2S1PT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02118
Supporting cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.592
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.825
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07448
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.468
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.832957
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEx Skin 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-5.94507
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52951
hippocampus (cortex Ammonis)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01852
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.72812
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.49557
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.52718
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.93356
Penis_Foreskin_Keratinocyte_Primary_Cells_skin02	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.830044
Osteopetrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05192
SPI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.87239
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.08797
BB-16-BE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.367961
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Cation channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.824
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3504_GPN3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578554
G142	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GATA2-21666600-HMVEC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
A549_Danusertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137509
superficial stratum of r6BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27194
GSE214505_0_v_1_akr1b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bronchioalveolar carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.445
Primary somatosensory area, trunk	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11536
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202825_2_v_1_ano1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cells - EBV-transformed lymphocytes	GTEx Tissue Gene Expression Profiles 2023	1.0	2.04245
b-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.466111
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPR173	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00324
TRIM28-19339689-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
abnormality of the liver	HPO Gene-Disease Associations	1.0	null
Iron	dbGAP Gene-Trait Associations	1.0	0.008237
pre-B cell differentiation	GO Biological Process Annotations 2023	1.0	null
NUGC-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.919419
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253856
lung	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.855362
GTEX-WFON-2526-SM-3LK7P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916027
GTEX-WFG7-0926-SM-4LMK7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.98559
VDR-24787735-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A905-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052531
Astrocyte_Brain_Human	CellMarker Gene-Cell Type Associations	1.0	null
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
AE-14-NN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.378358
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053664
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90798
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.77671
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE154577_7_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92574
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12136
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XLM4-2926-SM-4AT59	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92841
GSE134375_3_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU1J-0326-SM-46MUM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44776
Sinusitis	DisGeNET Gene-Disease Associations	1.0	null
ATF2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5ES-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ME-93-CO85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233105
A549_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157839
BRCA1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-2.05576
protein complex oligomerization	GO Biological Process Annotations 2025	1.0	null
various	GeneRIF Biological Term Annotations	1.0	null
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20386
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-79-5596-01A-31R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294632
Acute Myeloid Leukemia_LAML_TCGA-AB-2937-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9420_TUBB_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.586646
mineral metabolism disease	GWASdb SNP-Disease Associations	1.0	0.330638
Cervical cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
USF1_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Exocrine acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.962
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
C4-dicarboxylate transport	GO Biological Process Annotations 2025	1.0	null
Calcium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.28
immature b cell differentiation	GO Biological Process Annotations 2015	1.0	null
ChIP_TRIM28_19339689	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-T5JW-1326-SM-4DM5G	GTEx Tissue Sample Gene Expression Profiles	1.0	3.38906
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
JF-62-LU77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.888837
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.901508
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
uterus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.47098
DAUDI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32636
GSE145639_1_v_6_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79862
MA-31-VM30_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336342
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Posterior parietal association areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31247
SMAD2	ChEA Transcription Factor Targets	1.0	null
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14985
GSE198683_1_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.830824
Lung adenocarcinoma_LUAD_TCGA-75-6214-01A-41R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230692
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.599
HOP-92	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.938133
lung fibroblast	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GE-40-GQ38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.567981
Prefrontal cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.207
MCAS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.15627
HELA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE211128_4_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25018
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.2271
GTEX-VJWN-0426-SM-3GIJI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55574
EHEB	CCLE Cell Line Gene Expression Profiles	-1.0	-2.22364
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cns infection	HPO Gene-Disease Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4899-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Alcohol poisoning_Pancreas_GSE3311	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.690194
K562_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177356
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.54954
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10593
TE8	CCLE Cell Line Gene CNV Profiles	1.0	1.33291
monoatomic ion channel complex	GO Cellular Component Annotations 2023	1.0	null
GSE132369,GSE132371_5_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.911499
MA-06-DJ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218359
ELF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCL3	ENCODE Transcription Factor Targets	1.0	null
PEER	CCLE Cell Line Gene CNV Profiles	-1.0	-1.92345
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.85951
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.45598
Primary somatosensory area, upper limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29636
PMC10794847-mmc2.xlsx-PBRM1_KD_up-Table_S1_Differentially_expressed_genes_with_PBRM1_knockdown_in_the_progenitor_state_Related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
C1QTNF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0421
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2842
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC4944136-srep28995-s2.xls-OTX2-gene_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LD-48-CY61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228653
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.18226
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GM12878	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.63506
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217541,GSE217543_0_v_1_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148200_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, trunk, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.10944
SKCO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38557
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Exanthema	DisGeNET Gene-Phenotype Associations	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21808
GSE226355,GSE226357_3_v_4_ybx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
r9 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10528
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8612
anophthalmia	IMPC Knockout Mouse Phenotypes	1.0	null
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.916915
GTEX-OXRK-0526-SM-3NB2F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06067
r9 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38822
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216043_11_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
URB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03909
Byzanthine Arch Palate	DisGeNET Gene-Disease Associations	1.0	null
monoatomic anion transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
Sertoli cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.616
EVSA-T	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-4.32135
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SC-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.986069
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE195559_6_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
URI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07456
Bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02864
Primary somatosensory area, upper limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71624
lung	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endogenous	GeneRIF Biological Term Annotations	1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-2926-SM-2TF66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93456
TE-15-RO34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313519
SP1	ENCODE Transcription Factor Targets	1.0	null
CF-48-QD87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.589663
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
rectum_8c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.835121
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.13606
guanine nucleotide transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
estradiol_homo sapiens_gpl570_gse29881	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
layer 1 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.23179
CTCF_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DYRK1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48869
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7583-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nitrogen compound transport	GO Biological Process Annotations 2025	1.0	null
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12118
GTEX-OIZH-3026-SM-3NB1G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01096
dorsal part of PcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05769
MYD88_Deficiency_GDS2650_652_mouse_LUNG	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
ID-90-NM43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256225
CSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33936
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.391931
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
Malignant Tumor Of Colon	DisGeNET Gene-Disease Associations	1.0	null
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
G120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06697
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TCF12	ENCODE Transcription Factor Targets	1.0	null
Perturb_17317_KO_Ddx5_SRP284247	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.2675
dehydration	HPO Gene-Disease Associations	1.0	null
KYSE-150	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.835805
H3K4me1_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
dorsal motor nucleus of the vagus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.952325
periventricular stratum of r2Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.48562
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-86-XI84_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.72682
agammaglobulinemia 5	OMIM Gene-Disease Associations	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CB-02-XL81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.327955
MGE-Lateral region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.97613
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE70935_3_v_5_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CITED4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11779
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.08242
CC-03-PW00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202838
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25452
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KAT2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_Activation - 24 hours_GDS2025_726_mouse_Pancreatic islet beta cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-P4QT-0126-SM-2I3FL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826815
abnormality of the upper respiratory tract	HPO Gene-Disease Associations	1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3690	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Gonadotrophic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.171
Abdominal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.622
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.391
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.38443
SP2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UJHI-0226-SM-4IHJL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02001
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28405
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE169205_3_v_2_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S3.xlsx-Day_4_GATA6-dependent_genes-GATA6-dependent_mRNA_expression_Day_4_Definitive_Endoderm_FDR_0_05_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-429	TargetScan Predicted Conserved microRNA Targets	1.0	0.075559
DDR1_knockdown_169_GSE39207	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	3.13631
Perturb_1490_KO_Rpl23a_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.32903
Perturb_11401_KD_ECI2_SRP066238	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.4799
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SETDB1-19884257-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.964821
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.03481
AE-78-XJ76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262786
JVM2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51932
MRPL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10317
GTEX-U8XE-1226-SM-4E3HN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15979
hsa-miR-4486	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
HA-22-CY42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229957
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.94
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38346
BICR22	CCLE Cell Line Gene Expression Profiles	1.0	1.82582
AA-52-JS03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.34794
ATF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
15496427-Table4	GeneSigDB Published Gene Signatures	1.0	null
Sarcoma_SARC_TCGA-DX-A3UC-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.567
membrane	GeneRIF Biological Term Annotations	1.0	null
Osteosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
GTEX-XAJ8-0626-SM-47JY4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849572
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19087
hsa-miR-4763-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Recurrent Respiratory Infections	DisGeNET Gene-Phenotype Associations	1.0	null
Perturb_293_KO_GPX4_SRP255715	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
A-CA-04-2009(H1N1)_36Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.91622
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.3594
GSE48812_8_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.02981
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.22
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.18671
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.45367
GSE128333_2_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BOD1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33631
17724462-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-QDVJ-0626-SM-48U1T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.99125
Penis_Foreskin_Keratinocyte_Primary_Cells_skin03	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.999079
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.222
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Astrocyte_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.619859
SP1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831818
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.810835
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.990709
medial part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31238
Brain Lower Grade Glioma_LGG_TCGA-DH-5141-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052723
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.35
E2F4	ENCODE Transcription Factor Targets	1.0	null
GTEX-S4UY-0426-SM-3K2AF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04415
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
stratum radiatum of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20849
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72001
NUGC4	CCLE Cell Line Gene CNV Profiles	1.0	1.82879
Seminiferous tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.588
BC3H1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.473
Parotid acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.217
positive regulation of peptide hormone secretion	GO Biological Process Annotations 2023	1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AH-2026-SM-2S1PX	GTEx Tissue Sample Gene Expression Profiles	1.0	3.22949
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.02438
GSE85880,GSE85881_4_v_2_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NSUN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46497
BSDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99994
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64695
Myotonia congenita	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.162
JUND-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Transport of small molecules	Reactome Pathways 2024	1.0	null
hsa-miR-1587	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE154577_2_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.62008
GSE215086_1_v_7_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RAD21_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91537
ROCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11213
Common Wart	DisGeNET Gene-Disease Associations	1.0	null
SMAD3-18955504-HaCaT-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-X62O-2226-SM-46MW3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872158
K562_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179806
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE212848_1_v_0_pum1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.686
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00365
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06447
SLC12A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41585
GSE193993_0_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perisynaptic space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.249
GTEX-OIZH-0526-SM-2HMKV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938312
GSE60217_1_v_9_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
abnormal thymus physiology	MGI Mouse Phenotype Associations 2023	1.0	null
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
substantia nigra, pars compacta, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.17963
Dentate gyrus, granule cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49574
GTEX-WI4N-1026-SM-3LK7N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869207
LK2_LUNG	CCLE Cell Line Proteomics	1.0	2.2131
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5323-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE229468,GSE229471_0_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
MEIS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24565
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936517
STING complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.018
RUNX1_KO_GDS1511_251_mouse_Embryos at E12	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72473
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905048
EE-99-ZM45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287771
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YD38	CCLE Cell Line Gene CNV Profiles	1.0	1.75253
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0706
r8 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47576
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cabozantinib (S-malate)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0260776
Primary somatosensory area, barrel field, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84089
GSE121198,GSE129779_3_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ALX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51838
NKX2-5-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SUM1315MO2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.04643
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.353
Microglial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.179
lateral trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24359
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16166618-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
CTCF_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z6-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WholeBlood	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.32929
Lung adenocarcinoma_LUAD_TCGA-78-7542-01A-21R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
GAREM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44035
BCL11A	ENCODE Transcription Factor Targets	1.0	null
Hippocampal formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14506
Allergic disease (asthma, hay fever or eczema)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.852288
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060982
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE123638,GSE123639_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02428
ATF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-5311-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE154577_2_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal eye morphology	IMPC Knockout Mouse Phenotypes	1.0	null
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
C127I cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.244
PSN1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.887074
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	1.99325
CSTB_KO_GDS5090_199_mouse_Cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SF767	CCLE Cell Line Gene CNV Profiles	1.0	1.3671
GTEX-XUZC-2026-SM-4BRW9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.27417
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95302_2_v_3_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
HEP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
20min_EGF vs ctrl_HeLa (Human) [17081983]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands	1.0	null
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE261563_3_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
2790_EXOSC3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.504647
outer CP in (rostral) midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885561
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
autosomal dominant inheritance	HPO Gene-Disease Associations	1.0	null
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.903064
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
Atherosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z2-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BICR22	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.16041
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87839
nfe2l2_22586274_liver_lof_mouse_gpl4134_gse35124	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.650259
Ost-alpha/Ost-beta complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.55
PMC9424213-41467_2022_32537_MOESM5_ESM.xlsx-HeLa_IER3-AS1sh_DEGs-DEGs_in_HeLa_IER3-AS1sh_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7J9-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KAT2B	ENCODE Transcription Factor Targets	1.0	null
NCIH211	CCLE Cell Line Gene Expression Profiles	-1.0	-1.85203
inorganic anion transmembrane transport	GO Biological Process Annotations 2023	1.0	null
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
GTEX-R55G-0826-SM-2TC5U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866472
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.87933
GSE191037_0_v_1_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S4P3-0426-SM-4AD56	GTEx Tissue Sample Gene Expression Profiles	1.0	2.2206
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lymphnode_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.954702
2812_F8A1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.566986
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.93208
decreased B cell number	MGI Mouse Phenotype Associations 2023	1.0	null
ZNF771	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4684
ELAVL1	Pathway Commons Protein-Protein Interactions	1.0	null
JHOS4	DepMap CRISPR Gene Dependency	1.0	2.75286
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
OCIAML2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.90974
lateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09623
HDAC6	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BC-76-HY47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.670503
17676974-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE233679_12_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIG-M5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26035
Hesperidin_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0169142
cation-transporting ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.376
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE150049_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MHH-PREB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FE-06-GR60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.585286
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-RY-A840-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.923
Nucleus y	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08017
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-338-DOT1L_DOT1L	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QLQ7-1926-SM-2S1R6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4381
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.276495
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Contractile vacuolar membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.563
PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
ATF3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MFE280	CCLE Cell Line Gene CNV Profiles	1.0	1.82261
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2277
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70J-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gbm cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.142
BV173	CCLE Cell Line Gene Expression Profiles	-1.0	-1.9575
cell activation	GO Biological Process Annotations 2015	1.0	null
GSE196117_1_v_7_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Retrosplenial area, lateral agranular part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27763
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Colon Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
RCOR1-19997604-NEURONS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-SNOS-1726-SM-32PLN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858495
JUND_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
hypoglossal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1246
ATF3	ENCODE Transcription Factor Targets	1.0	null
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8151
H2BK15ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
caudal subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.888944
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
monoatomic ion channel activity	GO Molecular Function Annotations 2025	1.0	null
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial part of r8B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31591
GSE121198,GSE129779_3_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ethinyl estradiol_mus musculus_gpl75_gds285	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_17821_KO_Stat1_SRP277338	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GABPA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XV7Q-0826-SM-4BRV7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10617
G-MEL	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.35478
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312215
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Entorhinal area, lateral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02785
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T8EM-0426-SM-4DM7E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06817
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05602
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.30653
Dentate gyrus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18362
GTEX-PSDG-0526-SM-2S1OH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97985
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
RCOR1	ChEA Transcription Factor Targets	1.0	null
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.887954
MA-43-MR37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257623
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.875
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
mRNA_POU5F1_20526341	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838953
Verteporfin_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0191029
PMC7782698-41467_2020_20367_MOESM9_ESM.xlsx-Student_s_t-test_BP1_ILK_GFP-Gene_names_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.0476
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39737
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.789329
GSE153354_0_v_1_tcf19_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.394
PMC11459127-pnas.2406837121.sd04.xlsx-Sheet1-AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Posterior parietal association areas, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87675
FOXP1-21924763-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of PCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19947
GSE140997_4_v_3_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.381359
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340346
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214897
TBX5-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
lysosome	GO Cellular Component Annotations 2023	1.0	null
reduces	GeneRIF Biological Term Annotations	1.0	null
Cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
NOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46586
BD-61-OO16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.939514
Medullary collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.726
dorsal thalamus_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.949727
KLF4-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
LRRC75B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25573
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Umbilical vein endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
PMC3680531-cc-12-1510-s02.pdf-23-ZNF655_ZNF655	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZS-06A-12R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5355-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H4K91ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
S-117	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ETS1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6861-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H9 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.03814
Entorhinal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09776
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0723
dorsolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13983
PRDM14-20953172-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Cellulitis	DisGeNET Gene-Phenotype Associations	1.0	null
hsa-miR-370	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
3422_GMNN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500139
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18473
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826014
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.889155
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_5_TbID_-biotin_ERM_proteo-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.884666
PMC10274745-media-4.xlsx-S3A-Table_S3_Reanalysis_of_publicly_available_data_to_identify_AR_and_ER_direct_target_genes_related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NPJ8-2626-SM-2D7W2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13506
Obesity	DisGeNET Gene-Disease Associations	1.0	null
A549_ZM 447439_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.011501
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
Fusidic acid_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0225038
NFYA	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Anteromedial visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07841
SUPT3H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02921
GTEX-XAJ8-0726-SM-47JY5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917357
7565_RRP36_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.607129
Fenofibrate_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0268145
SMAD3	ChEA Transcription Factor Targets	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Z-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-6_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
TO14	DepMap CRISPR Gene Dependency	1.0	2.15839
Liver Diseases	CTD Gene-Disease Associations	1.0	1.04978
Sarcoma_SARC_TCGA-UE-A6QU-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63297
Hypothalamus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.938161
GSE48812_8_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.367675
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pyramidal layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37069
TCF12_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GF-37-MB64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.358763
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05981
Perturb_3782_KD_RGS18_SRP041162	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Pia mater	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.527
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.31
MTA3	ENCODE Transcription Factor Targets	1.0	null
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU2F2	ENCODE Transcription Factor Targets	1.0	null
superficial stratum of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12144
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99585
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7177-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HNF4G_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-193b	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
Anteromedial visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12419
OC-314	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.662
SMAD4-21799915-A2780-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.67
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I7-06A-22R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38967
NB13	DepMap CRISPR Gene Dependency	1.0	3.60412
spanning component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.496205
YF-47-HO48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297692
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH2171	DepMap CRISPR Gene Dependency	1.0	2.16063
SCC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HELA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.51484
GSE131649_6_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
transport	GO Biological Process Annotations 2015	1.0	null
GSE206516,GSE206518_2_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-15.0571
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.46144
AD-86-OB87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.28571
Astroglial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.206
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20418
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
KON	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.07407
PD-26-DC63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.321131
Vomeronasal organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.521
INPP5J	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26491
GTEX-UJMC-0726-SM-3GADX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25838
GTEX-WYJK-0826-SM-3NM8Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966086
abnormality of lymphocytes	HPO Gene-Disease Associations	1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.946337
Encephalomyelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
AD-37-UF49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248554
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A182-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Aurora A Inhibitor I_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144395
Lingula (I), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43613
Perturb_8676_KD_ZNF281_SRP251817	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.02332
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28528
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Ischemic Stroke	DisGeNET Gene-Disease Associations	1.0	null
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WA-15-KX40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202734
HPAC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.35536
CB-24-AT90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.507294
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12802643-mmc10.xlsx-EC2-EC2_Endothelial_subcluster_2_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1534	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.846967
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.78295
HS 895.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12005
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5834-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9332
GATA3-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
r10 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32377
r9 part of nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.044
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40065
SA-31-VB03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2714
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
Breast - Mammary Tissue	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.30515
ventrolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1408
GSE167474_1_v_3_naa40_human	RummaGEO Gene Perturbation Signatures	-1.0	null
miR-targeted genes in lymphocytes - TarBase(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
TAX1BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30936
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Fatty Liver	CTD Gene-Disease Associations	1.0	1.08904
UM-UC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.49141
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-2826-SM-3GADB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896094
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Subiculum, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18833
Endolysosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.897
Lung adenocarcinoma_LUAD_TCGA-69-8453-01A-12R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CF-24-KQ98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.508354
CTCF_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63691
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67752
PMC10037107-JEM_20221755_TableS6.docx-0-IL4-p_E382Q-STAT6_targets_in_Jurkats_1_STAT6	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of blood and blood-forming tissues	HPO Gene-Disease Associations	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.919096
GTEX-W5WG-2226-SM-4LMI3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26039
Glaucoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.519
intermediate stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36753
ID-90-NM43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.36211
Organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04409
Intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24859
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-let-7b-5p	MiRTarBase microRNA Targets	1.0	null
light-harvesting complex, core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.784
DC-45-WU45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.647082
YY1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HNF4A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.732
FOXO1_KD_GDS2720_477_mouse_LSK	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-T5JC-1726-SM-4DM6U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10482
TRIM28_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P44H-0426-SM-2XCEZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07033
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mantle zone of CA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01508
anterior (rostral) cingulate (medial prefrontal) cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.89957
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838002
GTEX-S3XE-1826-SM-3K2B4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.74878
JUND-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
HGC-27	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.17265
HTR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00251
guanine nucleotide transmembrane transport	GO Biological Process Annotations 2025	1.0	null
regulation of biological quality	GO Biological Process Annotations 2015	1.0	null
PK59	CCLE Cell Line Gene Expression Profiles	1.0	1.49357
CREB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Apicoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.747
Retrohippocampal region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00928
decreased CD4-positive, alpha-beta T cell number	MGI Mouse Phenotype Associations 2023	1.0	null
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.403661
GSE211215_1_v_0_akr1b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06289
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-A5G3-01A-31R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A2IZ-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TP53	ChEA Transcription Factor Targets	1.0	null
hsa-miR-3938	TargetScan Predicted Conserved microRNA Targets	1.0	0.050854
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.029
r4 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12002
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.842933
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.827522
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A5W8-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Luminespib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139835
SIN3A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239844_1_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
smoothmuscle_8c	HPA Tissue Sample Gene Expression Profiles	1.0	1.32455
HNF4A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A6M7-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_11420_KD_TMEFF2_SRP302700	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GTEX-RUSQ-0826-SM-47JWW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27017
cyclic nucleotide transport	GO Biological Process Annotations 2025	1.0	null
8661_TAF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.32792
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67578
4-aminobutyrate transaminase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.588
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.23588
UD-07-US73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.78575
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCF7L2_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GA-89-ZT62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20472
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3154
SNU398	DepMap CRISPR Gene Dependency	1.0	2.72661
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23946
Brain edema	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.877
spanning component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.496205
HCT-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Fetal_Intestine_Small	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.989944
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896714
Perturb_11439_KO_RB1_SRP253428	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.90968
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.848304
GTEX-U3ZN-2226-SM-3DB88	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975325
Primary somatosensory area, mouth, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07841
GTEX-PW2O-0426-SM-48TCC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07845
u937	HPA Cell Line Gene Expression Profiles	-1.0	-0.981081
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of skeletal morphology	HPO Gene-Disease Associations	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC5651844-41467_2017_1173_MOESM10_ESM.xlsx-ZZZ3_occupied_genes-Unnamed_5_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-14-CG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.681248
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0157
monoatomic anion transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
GSE71468,GSE76476_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
17616640-TableS3	GeneSigDB Published Gene Signatures	1.0	null
Arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
GTEX-O5YV-0626-SM-3LK64	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53265
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03475
8666_TAF5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.598849
PMC9232687-13238_2021_887_MOESM3_ESM.xlsx-37_KD_sgCDC20_vs_sgNTC-Differentially_expressed_genes_DEGs_upon_CDC20_knockdown_under_37_culture_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993506
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.780612
H4K20me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE235701,GSE261434_2_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
transporter complex	GO Cellular Component Annotations 2015	1.0	null
Glioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.232
JUN-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
5163_MPHOSPH10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.540227
KCL-22	COSMIC Cell Line Gene Mutation Profiles	1.0	null
OCI-AML3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.43948
HCC78	DepMap CRISPR Gene Dependency	1.0	2.94473
GATA3	ENCODE Transcription Factor Targets	1.0	null
BRD4-25478319-HGPS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormal eye morphology	HPO Gene-Disease Associations	1.0	null
GATA2_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8727_KD_ZNF414_SRP269946	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.3323
PMC12663032-mmc7.xlsx-Supp_T6-Supplemental_Table_6_Dual_treated_vs_vehicle_treated_MSC_top_DEGs_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Primary somatosensory area, barrel field, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.71398
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q734-2026-SM-3GADA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892377
MCF7_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139289
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.927914
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
b cell differentiation	GO Biological Process Annotations 2015	1.0	null
HSC-2	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.94367
Carcinoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.768
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.117
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23668
mantle zone of PcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0533
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_8_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05324
Retrosplenial area, lateral agranular part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30138
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMD1-0011-R3B-SM-4AT5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26285
dorsolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.914545
intermediate stratum of r8BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12851
protein complex oligomerization	GO Biological Process Annotations 2023	1.0	null
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.265663
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.56877
abnormality of the immune system	HPO Gene-Disease Associations	1.0	null
Caveola	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.625
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Serum metabolite concentrations in chronic kidney disease	GWAS Catalog SNP-Phenotype Associations 2025	1.0	4.1699
MEF2A	JASPAR Predicted Transcription Factor Targets	1.0	null
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00001
Kidney renal papillary cell carcinoma_KIRP_TCGA-UZ-A9PL-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305839
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.076
Perturb_11868_OE_Ezh2_SRP059688	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.77361
GTEX-WHSE-0126-SM-3NMBT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32035
abnormality of the bronchi	HPO Gene-Disease Associations	1.0	null
Cochlear nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.88013
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.53146
SNU1214	CCLE Cell Line Gene CNV Profiles	1.0	2.48675
ad158	GeneRIF Biological Term Annotations	1.0	null
GATA1_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013178
BC3C	CCLE Cell Line Gene CNV Profiles	1.0	1.34722
Tumor Progression	DisGeNET Gene-Phenotype Associations	1.0	null
Malabsorption	DisGeNET Gene-Phenotype Associations	1.0	null
GSE154577_6_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77763
Demyelinating disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
GTEX-OIZH-0226-SM-2YUMH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978142
Pimozide_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0260435
JUN_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23208
Field CA1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46436
GSE140997_4_v_6_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the globe	HPO Gene-Disease Associations	1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250757
hel	HPA Cell Line Gene Expression Profiles	-1.0	-0.874059
ATF1	ENCODE Transcription Factor Targets	1.0	null
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
unknown	GeneRIF Biological Term Annotations	1.0	null
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mast cells	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.844789
PMC10794847-mmc5.xlsx-PIAS1_KD_up-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.218212
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213228_4_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
AA-49-BD04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32843
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DD-42-DB72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.337904
abnormality of ion homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.152351
PMC11329632-41419_2024_6969_MOESM3_ESM.pdf-5-TFAP4_TFAP4	Rummagene Transcription Factor Associations 2026	1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
MCF10DCIS.COM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0918
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.60837
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
superficial stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.43922
premature death	MGI Mouse Phenotype Associations 2023	1.0	null
decreased pre-B cell number	MGI Mouse Phenotype Associations 2023	1.0	null
GSE135514_2_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BHY	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.54586
Chloride channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.653
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07677
A549_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152402
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.74574
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
Mean platelet volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.830103
Entorhinal area, medial part, ventral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03714
FOXA1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.914416
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14453
CD71+_EarlyErythroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.927486
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PP-0426-SM-3NM9H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08212
HCV JFH-1_24Hour_20200238_GSE20948	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.94661
GABP	MotifMap Predicted Transcription Factor Targets	1.0	null
FE-10-KQ78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.367799
GSE244710_1_v_0_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
caudal presubiculum (postsubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2013
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66879
igr39	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.502
hsa-miR-609	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Meckel syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.859444
Autosomal dominant vitreoretinochoroidopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.641
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.335968
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.996
CatSper complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.991
GSE131649_6_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_13113_KO|KD_Mbnl1/Mbnl2|Mbnl3_SRP045573	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.41389
dorsal cochlear nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08914
PMC5637904-PATH-243-193-s015.xlsx-human_down_in_ductal_SOX11-Unnamed_6_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SN8G-0326-SM-32PLG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19276
hsa-miR-3618	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
Leucine-rich repeat	InterPro Predicted Protein Domain Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A42Q-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EX-01A-12R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.40328
GSE151083_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Retinitis Pigmentosa_Retina_GSE128	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.19365
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TA-19-YA45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.365475
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14463
MCF7_Busulfan_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148198
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.848282
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.646
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.99667
GTEX-XBED-1026-SM-48TCB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835594
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38536
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
guanine nucleotide transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NPJ8-1826-SM-2YUNC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988801
Sertoli cell-only syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.342
PMC9305137-PATH-256-297-s005.xlsx-CIC_associated_DE_genes_IDH1-R-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DND-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.423974
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
YY1-26981420-C2C12-MOUSE-MUSCLE	ChEA Transcription Factor Targets 2022	1.0	null
OE21	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IB-06-YD91_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.515663
DB-24-CQ08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316826
Perturb_3775_KD_DPPA5_SRP041162	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_16088_KD_Pml_SRP306364	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.56064
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nuclear receptors meta pathway	WikiPathways Pathways 2024	1.0	null
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.909
NOP53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96291
PMC12616242-can-24-3452_supplementary_table_s4_suppst4.xlsx-EWSR1-FLI1-KDM6B_genes-Genes_associated_to_EWSR1_FLI1-KDM6B_peaks_in_A-673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
TE-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XUJ4-2826-SM-4BOQ2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29605
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
pre-B cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.144
Perturb_8884_KD_UPF1_SRP142324	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.51703
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.836148
ESR1-26153859-T47D-HUMAN-BREAST-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.953394
HNF4, COUP	MotifMap Predicted Transcription Factor Targets	1.0	null
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organic anion transport	GO Biological Process Annotations 2025	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A6SG-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941062
hsa-miR-655	TargetScan Predicted Conserved microRNA Targets	1.0	0.088999
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952017
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4698-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257448
r7 part of parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64696
A549_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161441
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Zbtb2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.2336
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adenine nucleotide transport	GO Biological Process Annotations 2023	1.0	null
Primary somatosensory area, barrel field, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.89268
Perturb_13950_KD_IGF2BP1_SRP291708	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.79037
SMC3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMEL	CCLE Cell Line Gene Expression Profiles	1.0	2.29099
TD-31-KS49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218006
GSE195559_0_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.992068
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.64343
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.609
transmembrane transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.004883
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
purine ribonucleotide transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
Middle cerebral artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.535
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
dorsal endopiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6301
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10165825-13046_2023_2674_MOESM1_ESM.xlsx-Supplementary_Table_S7-Supplementary_Table_S7_Differential_expression_results_for_the_TEAD-TP63_directly_regulated_genes_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.23575
Penis_Foreskin_Fibroblast_Primary_Cells_skin02	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.854638
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68T-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221577_1_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TFEC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6374
PMC12803930-mmc1.pdf-39-CSRNP2_CSRNP2	Rummagene Transcription Factor Associations 2026	1.0	null
GR-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.75149
Neuroinflammation and glutamatergic signaling	WikiPathways Pathways 2024	1.0	null
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-PVOW-1626-SM-48TC9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43207
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13359
Perturb_12092_KD_Krt14_SRP066319	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.2643
molecular layer of S	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41143
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BE-31-XV38_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211282
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.60207
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14230_KO_Dpagt1_SRP230444	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.80338
D-54MG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.626
Cerebral artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.529
VMRCLCD	DepMap CRISPR Gene Dependency	1.0	6.07442
increased regulatory T cell number	MGI Mouse Phenotype Associations 2023	1.0	null
STING-associated vasculopathy with onset in infancy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
integral component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.152271
adenine nucleotide transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
superficial stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64782
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
ATF3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4IQ-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYBL2	ENCODE Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A894-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S341-0526-SM-4AD5U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28008
H3118	DepMap CRISPR Gene Dependency	1.0	2.51016
positive regulation of insulin secretion	GO Biological Process Annotations 2023	1.0	null
PNMA8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05771
Fanconi-like syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
monoatomic ion transport	GO Biological Process Annotations 2025	1.0	null
Plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC4728380-ncomms10153-s8.xlsx-High_affinity_MYC_Targets-Unnamed_0_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of the intestine	HPO Gene-Disease Associations	1.0	null
SARS-CoV_48Hour_20090954_GSE17400	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.7601
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35359
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
glucose homeostasis	GO Biological Process Annotations 2025	1.0	null
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03266
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.455
Dentate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69068
GSE171401_1_v_0_adnp_human	RummaGEO Gene Perturbation Signatures	1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
ZNF217_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.932
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.48331
layer 2 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.93563
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.88882
AB-74-VK99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235397
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.36458
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-Gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.408
Asthma, allergic_Lung Tissue_GSE3184	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.43828
Perturb_7219_KD_RNF2_SRP321650	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
NCIH1581	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47899
NCI-H1770	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34009
r8 part of inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.10163
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
AA-56-QO38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326388
496100438_PCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.47146
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
superior temporal gyrus, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.868221
E2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cloning	GeneRIF Biological Term Annotations	1.0	null
16166618-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
Agenesis of the corpus callosum with peripheral neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.39
Brain Lower Grade Glioma_LGG_TCGA-DU-5871-01A-12R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUZC-0426-SM-4BOPE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.99957
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Peripheral motor neuropathy_Sciatic Nerve_GSE1947	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.0671
single-organism process	GO Biological Process Annotations 2015	1.0	null
Perturb_15512_KD_FOXA1_SRP353748	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.72664
Anterior olfactory nucleus, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50028
GABPA_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7141_RBBP5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.57475
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lytic vacuole membrane	GO Cellular Component Annotations 2023	1.0	null
WC-33-YP46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240788
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE174498,GSE174500_5_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16618758-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
abnormality of the ocular region	HPO Gene-Disease Associations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5332-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OHPK-0426-SM-3MJH3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62509
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21097
VZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.931914
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blood protein disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.01554
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.356
putamen, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.901266
GTEX-OOBJ-0426-SM-3NB1S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934903
Perturb_11446_KD_TMEFF2_SRP302699	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.7397
Lysosomal membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GTEX-RUSQ-0326-SM-47JWS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57118
GSE131660_1_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153867_6_v_4_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE247230_0_v_1_anp32b_human	RummaGEO Gene Perturbation Signatures	1.0	null
CDK7_knockdown_138_GSE31534	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.1609
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261905
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39147
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Colon - Sigmoid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.56807
MCF7_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129828
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.53159
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ELF1-20517297-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3901
PMC9170756-mmc6.xlsx-all_differential_proteins-Table_S3_The_JUN-targeted_responders_to_FFA_treatments_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
H3K79me2_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831423
Lysosomal lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.748
MCF7_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131772
bed nucleus of stria terminalis	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.833474
Pancreatic delta cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.083
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
r9 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25857
FOXP3-21729870-TREG-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
10123_ZIC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.873664
A-Vietnam-1203-2004(H5N1)_24Hour_None_GSE43204	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.96101
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.895623
r7 part of rostral ventromedial reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70548
Lung squamous cell carcinoma_LUSC_TCGA-98-A539-01A-31R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019754
COLO-818	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.846967
NLRP3 inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.601
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11751
Perturb_263_KO_GPX4_SRP255715	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
TF-29-QU48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.300096
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A196-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cus cation efflux complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.986
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1YX-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AD-18-XC14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269605
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.004756
PMC9988762-43032_2022_1002_MOESM1_ESM.xlsx-Integrate_DEGs_PGR_Gain_Site-Gene_Symbol_PGR	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.835805
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08765
BV-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.049
Inner medullary collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.73
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNUPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7543
GTEX-R55C-0826-SM-48FCL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25015
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
leukocyte differentiation	GO Biological Process Annotations 2015	1.0	null
BC-09-JG96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211892
GSE223908,GSE223909_1_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	3.05478
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929191
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.43381
monoatomic ion channel complex	GO Cellular Component Annotations 2025	1.0	null
Phenylephrine (hydrochloride)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0145179
intermediate part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08923
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	-1.0	null
lytic vacuole membrane	GO Cellular Component Annotations 2025	1.0	null
abnormality of granulocytes	HPO Gene-Disease Associations	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30035
Pancreatic adenocarcinoma_PAAD_TCGA-2L-AAQA-01A-21R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AE-19-BK71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214104
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.28333
CNS cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.506
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HIV_Infected-mDC_None_GSE42058	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.8618
Prostate adenocarcinoma_PRAD_TCGA-HC-7821-01A-12R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
FOXP2	ENCODE Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DH-A66F-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37362
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
superficial stratum of CA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01852
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32538
r7 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67794
SNU-C2B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MBD4	ENCODE Transcription Factor Targets	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05357
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.14968
Pulmonary artery endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.238
4822_MAP7D1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.541098
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.394
HELA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CBC184 (BICD2)	NURSA Protein Complexes	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.838747
localization	GO Biological Process Annotations 2015	1.0	null
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ1-1226-SM-4GICJ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18912
GD-82-CS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.297184
BA-75-VA57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303042
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.993713
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.997927
SNU5	DepMap CRISPR Gene Dependency	1.0	4.40384
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fatigue	DisGeNET Gene-Phenotype Associations	1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IM-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CREB1-23762244-HIPPOCAMPUS-RAT	ChEA Transcription Factor Targets 2022	1.0	null
orbital frontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.914298
LD-69-ZV56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228903
TYK2_knockdown_35_GDS4754	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.65338
SREBF2	ChEA Transcription Factor Targets	1.0	null
SARS-CoV MA15_Day2-PFU-10^2_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.51781
GSE184892_6_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
Aorta thoracica smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.712
PMC12035534-gfae237_supplemental_file.pdf-65-IRF2_IRF2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
Bronchiectasis	DisGeNET Gene-Disease Associations	1.0	null
MITF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2867
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1001
GSE134375_3_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12703482-AMS-21-5-213605-s2.xlsx-Supplementary_Table_SXVI-SMR_results_of_expression_levels_of_VDR_target_genes_in_peripheral_blood_and_risk_of_prostate_cancer_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
facial motor nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12756
GTF2B	ENCODE Transcription Factor Targets	1.0	null
r6 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08781
Lung squamous cell carcinoma_LUSC_TCGA-18-5592-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.93761
CML-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100340_TCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14352
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10028
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25067
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2558
hsa-miR-4521	TargetScan Predicted Conserved microRNA Targets	1.0	0.123298
NUGC2	CCLE Cell Line Gene CNV Profiles	1.0	1.38404
GSE146982_7_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 2 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0871
hsa-miR-613	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
Lung adenocarcinoma_LUAD_TCGA-53-7624-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hs-766T	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	3.53448
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	1.0	null
E2F1	ENCODE Transcription Factor Targets	1.0	null
GSE135030_8_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201735
Subfornical organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.009
CSTB_KO_GDS5090_200_mouse_Cerebellar granule cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T8EM-1626-SM-3DB7K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951801
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20362
bone marrow	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.24486
Hepatitis, Autoimmune_Hepatic Tissue_GSE867	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.81141
DB-56-XL71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.5149
K562_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160441
MAP3K6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13081
abnormality of iron homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.447412
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-X4XY-1726-SM-46MVO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16468
GSE109565_12_v_4_glyphosate_human	RummaGEO Drug Perturbation Signatures	1.0	null
AE-38-LX10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370186
Orthogonal array	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.844
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22336
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0691
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.870418
iron metabolism disease	GWASdb SNP-Disease Associations	1.0	0.524507
ATPase dependent transmembrane transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.183
neoplasm by anatomical site	HPO Gene-Disease Associations	1.0	null
DAN-G	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.508
GSE249098_3_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.85139
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98216
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58779
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Natural killer cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.35
JD-00-YJ41_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221801
Verteporfin_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0171846
CCK81	CCLE Cell Line Gene Expression Profiles	-1.0	-1.62285
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3975	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.846967
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF3-23680149-GBM1-GSC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01393
types	GeneRIF Biological Term Annotations	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04538
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.910838
NCOR1-26117541-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5710-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
decreased DN3 thymocyte number	MGI Mouse Phenotype Associations 2023	1.0	null
NE-00-JZ19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221104
ZSCAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32268
GTEX-XBED-2426-SM-4AT4O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58824
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.45067
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TEAD2_TEAD2	Rummagene Transcription Factor Associations 2026	1.0	null
CIART	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20078
Lung squamous cell carcinoma_LUSC_TCGA-94-A5I4-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
JB-23-ZE86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318724
Rectum adenocarcinoma_READ_TCGA-EI-7004-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Penfluridol_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0271362
5213_MRPL30_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.61438
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19405
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.71439
DA-81-VY50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269921
BC-09-XN48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.752547
SARS-CoV MA15_Day7-PFU-10^3_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.93492
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7390-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRIM28	ChEA Transcription Factor Targets	1.0	null
KLF4-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
positive regulation of myoblast differentiation	GO Biological Process Annotations 2025	1.0	null
hsa-miR-1908	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Esophageal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
CYB561D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17415
MAX_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ5-0426-SM-3P612	GTEx Tissue Sample Gene Expression Profiles	1.0	2.23712
TKKK	DepMap CRISPR Gene Dependency	1.0	4.83309
5205_MRPL21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.633932
PMC7064337-elife-51373-supp2.xlsx-847_genes_down-regulated-List_of_847_genes_down-regulated_after_PHF19_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
COLO201	CCLE Cell Line Gene Expression Profiles	1.0	1.43247
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXP1	ChEA Transcription Factor Targets	1.0	null
Diarrhea	DisGeNET Gene-Phenotype Associations	1.0	null
S0-EE-Y6WJ_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346095
TEAD4_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09921
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.275
AD-30-VB23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.332077
TMEM63A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46597
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FA-36-VA24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.732358
superficial stratum of r7BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6834
MAX	ENCODE Transcription Factor Targets	1.0	null
r10 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10951
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.45403
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
QB-88-PG52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346868
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U8XE-2526-SM-4E3IT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01736
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_2_ZZZ3_occupied_genes-ATAC1_bound_genes_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
outer CP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.897951
hsa-miR-511	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
Erlotinib_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0258035
irinotecan_rattus norvegicus_gpl1355_gds3466	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46H-01A-31R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-1.18556
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896714
Renal distal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.962
colon	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.09882
Prostate adenocarcinoma_PRAD_TCGA-EJ-8472-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain - Cerebellum	GTEx Tissue Gene Expression Profiles 2023	1.0	2.94976
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5A	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
protein binding	GO Molecular Function Annotations 2015	1.0	null
morphological abnormality of the gastrointestinal tract	HPO Gene-Disease Associations	1.0	null
GTEX-XMD1-0011-R6A-SM-4AT5K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27231
Micronucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.828
intrinsic component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.135321
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Heart - Left Ventricle	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.85327
Thymopentin_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.021848
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Primary somatosensory area, trunk, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27664
Perturb_12249_KD_ESRRA_SRP028155	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_16309_KD_RECQL4_SRP270276	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.6116
GSE169590_6_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.441092
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
Traumatic brain injury	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.453
Astrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.208
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.84458
EP300_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9643473-Table1.xls-MAF_0_005-HGVS_gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
BE-70-YH17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270545
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7211-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10154691-Table2.xlsx-Table_2B-Table_2B_Significantly_differentially_expressed_AR_target_genes_fold_change_Log2_1_and_FDR-corrected_p-value_0_05_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FB-33-LI31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.532189
small spleen	MGI Mouse Phenotype Associations 2023	1.0	null
RKO	CCLE Cell Line Gene CNV Profiles	1.0	1.92444
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54018
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
11192_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504537
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14949
GSE175787_8_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cortical collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.005
PMC10915192-ab-23-0304-Supplementary-Table-S7.pdf-17-MEIS2_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
irinotecan_rattus norvegicus_gpl1355_jejunum_gds3466	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormal respiratory system morphology	HPO Gene-Disease Associations	1.0	null
HA-32-YH61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.707983
DC-47-KV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.43788
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-5775-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.43258
iodide	GeneRIF Biological Term Annotations	1.0	null
PDCD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0057
Visceral hump	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.589
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.54734
YY1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of r9BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10669
Lung adenocarcinoma_LUAD_TCGA-44-7662-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-GT-4	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.34549
FOS	ENCODE Transcription Factor Targets	1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52572
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.958615
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08596
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.70184
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
PMC12703482-AMS-21-5-213605-s2.xlsx-Supplementary_Table_SXIV-SMR_results_of_expression_levels_of_VDR_target_genes_in_peripheral_blood_and_risk_of_melanoma_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.54239
GC-73-YI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.26783
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_4_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KDF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08929
TB-06-VB30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.58315
VTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40097
EE-01-FB85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280196
KC-21-PG56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215527
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-O5YW-0526-SM-2YUMX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42467
entorhinal cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04984
neoplasm of the skin	HPO Gene-Disease Associations	1.0	null
Field CA1, stratum pyramidale	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33798
QGP1_PANCREAS	CCLE Cell Line Proteomics	1.0	2.94038
H3K27ac_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2M5-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRF_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vas efferens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.532
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOXB4	ChEA Transcription Factor Targets	1.0	null
SP2	ENCODE Transcription Factor Targets	1.0	null
posterior orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3054
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.966605
Lymphoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.35
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.871722
subethmoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01681
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.02808
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0544
SMAD3-18955504-HACAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
TIRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61864
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39222
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.0613
PMC9643473-Table1.xls-MAF_0_005-Gene_refGeneWithVer_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TP63	ChEA Transcription Factor Targets	1.0	null
STAT5A	ENCODE Transcription Factor Targets	1.0	null
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38079
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal eye physiology	HPO Gene-Disease Associations	1.0	null
EC-01-PH79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227596
Pacemaker cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.746
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.545
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.5502
WA-62-RP29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260065
hsa-miR-200a	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.27286
Glaucoma	DisGeNET Gene-Disease Associations	1.0	null
abnormality of the skeletal system	HPO Gene-Disease Associations	1.0	null
hsa-miR-4802-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.285
1716_CNOT1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01687
outer SZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.890369
Glial cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.142
GTEX-PWO3-1026-SM-2I5F2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09814
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
four	GeneRIF Biological Term Annotations	1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAD cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.546
FOXD4L5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17896
GSE231829_0_v_1_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.506
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43823
H3K4me1_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.94964
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5440-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.07282
SKES1	CCLE Cell Line Gene CNV Profiles	1.0	2.15564
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BV173	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80139
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.897044
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F1-01A-11R-A034-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-DX-A3UA-01A-12R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RELA_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31916
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
supraoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00128
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TW-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XMD1-0011-R5A-SM-4AT47	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34089
AD-51-LE62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243901
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.69778
TMCO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22212
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5767-11B-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
10min_EGF vs ctrl_HeLa (Human) [17081983]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands	1.0	null
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.7598
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.929951
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967368
Pancreatic adenocarcinoma_PAAD_TCGA-FB-A5VM-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell volume homeostasis	GO Biological Process Annotations 2015	1.0	null
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C6 glioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.67105
TSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2025
NCIH1793	CCLE Cell Line Gene CNV Profiles	1.0	1.50814
GTEX-NPJ7-2826-SM-2I3FU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75465
GSE226770_1_v_6_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.76834
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.203
EGR1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Synaptic vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.802
Brimonidine_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0154603
GTEX-RU1J-0126-SM-2TF6Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17826
HCC78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00739
GSE142588_2_v_3_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.311682
dorsal motor nucleus of the vagus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.875599
urinarybladder_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.04244
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28528
Lung squamous cell carcinoma_LUSC_TCGA-85-8481-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4067464-onc2013378x3.xls-Sheet1-Supplementary_Table_1_Top_1000_E2F4_Chip-Seq_targets_that_are_repressed_by_p53_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_8_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GE-29-ZM45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232032
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9992472-41467_2023_36735_MOESM5_ESM.xlsx-SOX11_OE_9h_in_SH-EP-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
organic anion transport	GO Biological Process Annotations 2023	1.0	null
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
8645_TACC3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.6096
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
frontal pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.998089
BE-73-IJ64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.483457
umbilicalcord	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.02157
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Polycystic Ovary Syndrome_Skeletal muscle_GSE6798	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.44278
posteroventral (inferior) parietal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05893
Squamous Cell Carcinoma Of Esophagus	DisGeNET Gene-Disease Associations	1.0	null
NCI-H841	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Posterior parietal association areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33902
E2F6	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MR-01A-31R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.73137
RUNX3	ENCODE Transcription Factor Targets	1.0	null
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mantle zone of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03523
GSE224311_3_v_4_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55581
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
A-2780 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.411
EP300_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2710-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OXRN-1326-SM-3LK5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08799
FOXA1_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE108495_1_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-85-SU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.946899
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.868152
abnormal lung morphology	MGI Mouse Phenotype Associations 2023	1.0	null
HES3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61169
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.88094
digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ELF1	ChEA Transcription Factor Targets	1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OTX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6365
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-0626-SM-4LMK6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35039
reconstitute	GeneRIF Biological Term Annotations	1.0	null
USF1_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CFPAC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54398
NB7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
17880687-TableS3	GeneSigDB Published Gene Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CA-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE139540_0_v_2_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.00116
PMC9174260-41467_2022_30960_MOESM6_ESM.xlsx-S3-RAS2_unique_GATA2-Gene_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.91836
r7 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04127
GSE175787_13_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-67-PZ77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236683
PMC9509360-41419_2022_5262_MOESM6_ESM.xlsx-Fig_2D_MSC_targeted_RNF4-Down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
abdominal symptom	HPO Gene-Disease Associations	1.0	null
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30876
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15968
Orbital Separation Excessive	DisGeNET Gene-Phenotype Associations	1.0	null
CB-69-DJ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244292
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
cell surface	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
abnormality of immune system physiology	HPO Gene-Disease Associations	1.0	null
SUZ12	ENCODE Transcription Factor Targets	1.0	null
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.60537
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Glioma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-XUW1-1126-SM-4BONZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01672
Lung adenocarcinoma_LUAD_TCGA-55-8302-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BA-39-HG26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344699
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.873792
lymphocyte activation	GO Biological Process Annotations 2015	1.0	null
BC-82-PP66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.67558
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GD-46-BU97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.606171
CENPO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33438
SARC9371	COSMIC Cell Line Gene Mutation Profiles	1.0	null
abnormality of metabolism/homeostasis	HPO Gene-Disease Associations	1.0	null
CSTB_KO_GDS5090_398_mouse_cerebella	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3MA-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EFO-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.82493
primary auditory cortex (core)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18619
HNF4A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUN_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal T cell differentiation	MGI Mouse Phenotype Associations 2023	1.0	null
body of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.858547
ML264_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0227295
superior frontal gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.68172
GSE155162,GSE155169_1_v_3_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8603_SURF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.633024
COVID-19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
MA-43-MR37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304989
IMCD cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.882
Acute Myeloid Leukemia_LAML_TCGA-AB-2810-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21856
0min_EGF vs ctrl_HeLa (Human) [17081983]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands	1.0	null
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1864
RPP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81852
SP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.64027
PMC3636213-pgen.1003459.s012.xlsx-Sheet1-KD_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
FOXM1	ENCODE Transcription Factor Targets	1.0	null
BCAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14708
ELF1-20517297-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46414
esophagus_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.28374
DV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.85726
7607_RUVBL1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.625748
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.69144
FOSL2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17177833-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
CE-15-YU05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246985
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
S0-EE-YEL3_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22968
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.399217
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1919
hsa-miR-208a	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
Field CA1, stratum lacunosum-moleculare	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79393
HMEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.917821
intermediate stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05352
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCFCP2L1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01087
Cerebral degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.687
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
tm95	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.931
hsa-miR-1	MiRTarBase microRNA Targets	1.0	null
MYCN-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16634
H3K9ac_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE206226_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RM2N-0426-SM-2TF4T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924243
Fibroblast	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC6802116-41467_2019_12517_MOESM5_ESM.xlsx-Sheet1-D9_8_GNF2-SERPINB5_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.365
KBM-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.108
vincristine_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0259805
PMC7991738__F1	PFOCR Pathway Figure Associations 2023	1.0	null
volume-sensitive anion channel activity	GO Molecular Function Annotations 2025	1.0	null
lung cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054705
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1915	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
E2F4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM1A	ENCODE Transcription Factor Targets	1.0	null
diarrhea	HPO Gene-Disease Associations	1.0	null
MHH-PREB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
ZR-75-30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CBX3	ENCODE Transcription Factor Targets	1.0	null
PSN1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85741
H3K4me1_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ARID1A_01_108	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.603
FOXP3	ChEA Transcription Factor Targets	1.0	null
abnormality of cell physiology	HPO Gene-Disease Associations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6797-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
20460173-ImmPortComprehensiveListofImmune-RelatedGenes	GeneSigDB Published Gene Signatures	1.0	null
abnormal skeletal muscle morphology	MGI Mouse Phenotype Associations 2023	1.0	null
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HC-01-FD24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.38862
ion transport	GO Biological Process Annotations 2015	1.0	null
SIX5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1	ENCODE Transcription Factor Targets	1.0	null
GSE242555_1_v_0_fn3k_human	RummaGEO Gene Perturbation Signatures	1.0	null
SIN3B-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.84768
FOS_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THAP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
positive regulation of protein secretion	GO Biological Process Annotations 2025	1.0	null
GATA2-21666600-HMVEC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A8OC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.874568
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.19161
SKRC31	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55022
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40109
Cerebrovascular cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.647
GTEX-X8HC-2826-SM-46MWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3587
Alpelisib_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0107428
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08664
Perturb_82_KD_HOXC4_SRP192852	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.97345
METTL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02849
Brain Lower Grade Glioma_LGG_TCGA-HT-7608-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA1-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TM-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.776
MCF7_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124913
para-abducens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06378
GSE169590_0_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormality of globe location	HPO Gene-Disease Associations	1.0	null
el2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.645
HDGFL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08433
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.08516
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QT-1826-SM-2S1NJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00142
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SR cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.552
2307_DNASE1L1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.642341
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NANOG_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectal Mucosa Donor 31	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.17252
GSE195503_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.465133
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824187
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6952-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.654
CREB1-23762244-HIPPOCAMPUS-RAT	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
decreased double-negative T cell number	MGI Mouse Phenotype Associations 2023	1.0	null
BT-474	COSMIC Cell Line Gene Mutation Profiles	1.0	null
isoforms	GeneRIF Biological Term Annotations	1.0	null
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.450237
esophagus_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.5214
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14638
r10 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0576
Agammaglobulinemia	ClinVar Gene-Phenotype Associations 2025	1.0	null
H3K4me3_CD19 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
AB-85-JR73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.419916
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
testis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.15403
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
VMRCLCP	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4822
OE-75-WF43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.457336
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-68-7756-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
single-organism developmental process	GO Biological Process Annotations 2015	1.0	null
abnormal axial skeleton morphology	HPO Gene-Disease Associations	1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_3_TurboID_1hr_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
BHY cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.017
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bronchial epithelial cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.729
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.56732
MDAMB157_BREAST	CCLE Cell Line Proteomics	1.0	3.36736
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.636367
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241782
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25733
EBF1-22473956-LYMPHODE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06541
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15116
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.1002
AE-43-UJ94_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24193
Lingula (I)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41898
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMAD4-21799915-A2780-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
tonsil	HPA Tissue Protein Expression Profiles	-1.0	-1.30178
ELK4_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
currents	GeneRIF Biological Term Annotations	1.0	null
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BAEC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.846
NCIH2030	CCLE Cell Line Gene Expression Profiles	-1.0	-1.64647
CE-18-AP85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295181
ES-WA7 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.3688
import into cell	GO Biological Process Annotations 2023	1.0	null
m.dunni	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.571
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00268
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_foreskin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7505_RPS16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.746314
principal sensory nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12411
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.32474
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.871446
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.990104
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.19083
CCK-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cystic fibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.739
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.46689
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05726
GOTO	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.2354
AE-51-ZO26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.23435
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17532
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.951723
cellulitis	HPO Gene-Disease Associations	1.0	null
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WYJK-0426-SM-3NM9G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955554
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r2 part of vestibular nucleus Y	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.49311
JUN_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28125
GSE190316,GSE190324_0_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
genomic	GeneRIF Biological Term Annotations	1.0	null
Cervix - Ectocervix	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.936229
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24201
EB2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.930419
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate part of r8B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11515
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051333
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10058
capan2	HPA Cell Line Gene Expression Profiles	1.0	0.943703
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.36
ABCG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11941
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54J-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.679894
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100462_PCx_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.38642
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-N7MS-1626-SM-3LK5F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861515
QB-88-PG52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285171
BA-53-FM66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.367597
cingulate gyrus, retrosplenial part, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.4228
RPS13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0694
SUM190PT	DepMap CRISPR Gene Dependency	1.0	8.32097
GSE213228_1_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTF3C2	ENCODE Transcription Factor Targets	1.0	null
Sertoli cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.766
SCC-25	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.08369
NUGC-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
JHESOAD1	CCLE Cell Line Gene Expression Profiles	1.0	1.71224
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.54891
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gout	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.64236
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932153
GSE140997_2_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary somatosensory area, barrel field, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.33719
KAP1-27257070-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158008
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.842375
A549_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189268
Choroid plexus epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.706
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.978201
PMC11551338-pnas.2411189121.sd01.xlsx-VDR-Unnamed_0_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.55473
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040308
SNU1076	CCLE Cell Line Gene CNV Profiles	1.0	2.19022
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Malotilate_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.036421
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.56177
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AB-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HUVEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.861537
RPS4X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21917
high palate	HPO Gene-Disease Associations	1.0	null
CNTRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70865
22RV1	CCLE Cell Line Gene Expression Profiles	1.0	1.93792
NE-34-OZ69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.56939
CAL27	CCLE Cell Line Gene CNV Profiles	1.0	1.44088
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YW-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TM-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.83
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13801
BCL3	ChEA Transcription Factor Targets	1.0	null
FOXA2	ENCODE Transcription Factor Targets	1.0	null
Colon - Transverse	GTEx Tissue Gene Expression Profiles 2023	1.0	1.83196
GSE158834_0_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.28865
GSE196117_6_v_7_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD4_knockdown_223_GSE50865	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.41133
Lung adenocarcinoma_LUAD_TCGA-55-7726-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7248-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FD-48-HZ39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216806
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.585411
respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Accessory facial motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12156
CREB1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3663-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
abnormal craniofacial morphology	MGI Mouse Phenotype Associations 2023	1.0	null
GSE208171_0_v_1_zc4h2_human	RummaGEO Gene Perturbation Signatures	1.0	null
OVK-18	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GB-57-XV52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.365271
abnormal lung morphology	IMPC Knockout Mouse Phenotypes	1.0	null
BXPC3	CCLE Cell Line Gene Expression Profiles	1.0	1.80179
cellular developmental process	GO Biological Process Annotations 2015	1.0	null
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8384902-mmc6.xlsx-DEG_ASCL1_3TF_shared-GeneSymbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal immunoglobulin level	HPO Gene-Disease Associations	1.0	null
YAPC	CCLE Cell Line Gene Expression Profiles	1.0	1.50791
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
ATF2	ENCODE Transcription Factor Targets	1.0	null
prenatal lethality, incomplete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15954
volumeregulated	GeneRIF Biological Term Annotations	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2842
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
T-84 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.208
EOMES-20176728-TROPHOBLAST STEM CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.841812
BE-31-XV38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.349258
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51227
GTEX-SNOS-0326-SM-4DM6C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09516
thyroid	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.45303
hsa-miR-4693-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BA-77-US35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.57216
Pentoxifylline_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0274694
TRIM41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8525
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3152
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RD-50-EO07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272179
PMC12703482-AMS-21-5-213605-s2.xlsx-Supplementary_Table_SXIII-SMR_results_of_expression_levels_of_VDR_target_genes_in_peripheral_blood_and_risk_of_breast_cancer_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FA-88-II68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.347597
HEC108_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	3.68388
GTEX-S95S-0426-SM-4B64I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928118
WM2664_SKIN	CCLE Cell Line Proteomics	1.0	2.22979
influx	GeneRIF Biological Term Annotations	1.0	null
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10603
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-193a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36552
stomach_3b	HPA Tissue Sample Gene Expression Profiles	1.0	0.940646
Macular degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.10069
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_2_TurboID_10m_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
A549_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136113
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20745
MCAS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.983763
CE-24-LQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.367564
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.869483
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SETDB1	ChEA Transcription Factor Targets	1.0	null
GTEX-QV31-0326-SM-447BM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42624
K562_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0256324
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832987
esophagus	HPA Tissue Gene Expression Profiles	1.0	1.2371
fat_8b	HPA Tissue Sample Gene Expression Profiles	1.0	1.00959
Kidney Chromophobe_KICH_TCGA-KN-8421-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.90716
Aicardi-Goutieres syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.233
fourtransmembrane	GeneRIF Biological Term Annotations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4326-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KB-49-NF63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213109
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF417	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4885
hypoglossal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.5208
SKMEL1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.81876
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01087
GSE184892_7_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10442_KO_Zfhx3_SRP187824	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.2508
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24306
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Down Syndrome_CNS - Brain - Cerebellum (MMHCC)_GSE1611	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.90997
GSE220097_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ECC10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WEY5-2126-SM-3GILK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00031
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73B-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
positive regulation of cell differentiation	GO Biological Process Annotations 2023	1.0	null
DA-10-GX45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254028
Ventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6461
parietal cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19855
Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03082
estradiol_mus musculus_gpl75_gse280	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
small thymus	MGI Mouse Phenotype Associations 2023	1.0	null
Perturb_160_KD_Ago2_SRP259987	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.67426
Bone marrow-derived macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.303
Cochlear nucleus, subpedunclular granular region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.00818
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7336
Migraine	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
Brain Lower Grade Glioma_LGG_TCGA-DB-5279-01A-03R-2347-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLCB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0326
GTEX-OXRL-1826-SM-2YUMV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72253
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.340142
TAL1	ENCODE Transcription Factor Targets	1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.451
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5753-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43333
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT5A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1397
Hyperglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.29
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03906
Conjunctivitis	DisGeNET Gene-Disease Associations	1.0	null
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044436
CTCF_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_6_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7058-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PANC 05.04	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20552
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
TBX5-21415370-HL-1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_15121_KD_PRKAB1_SRP076036	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
A549_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158465
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BL-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
anion channel activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-XAJ8-1226-SM-47JYS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86911
MIR140_OE_GDS3461_575_mouse_C3H10T1/2 fibroblast cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CREB1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.829459
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.87412
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05779
Internal carotid artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.634
G43417UB	GlyGen Glycosylated Proteins	1.0	null
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-398	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896714
GTEX-XXEK-0726-SM-4BRWF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95909
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.73687
SP1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06449
RCOR1	ENCODE Transcription Factor Targets	1.0	null
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46669
EC-01-PH79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290697
NCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HN-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inner CP in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.994274
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.4726
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
r6 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45208
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74739
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QXCU-0926-SM-48FEP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38192
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A76R-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4336_KD_PML2_SRP221023	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.5705
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
RMC-6236_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0335543
membrane part	GO Cellular Component Annotations 2015	1.0	null
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5291205-srep41905-s3.xlsx-LPS_datasets_gmx-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
A172	DepMap CRISPR Gene Dependency	1.0	2.23147
substrate-specific channel activity	GO Molecular Function Annotations 2015	1.0	null
CTCF_fibroblast of lung_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.846894
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A0YX-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-SMAD3_target_genes_hES_SMAD3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
L540	CCLE Cell Line Gene Expression Profiles	-1.0	-1.90512
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.944227
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.0163
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33008
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Low Set Ears	DisGeNET Gene-Disease Associations	1.0	null
GTEX-XUZC-0626-SM-4BOPG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78017
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-51-4079-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ion channel complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.992079
GTEX-RWS6-0526-SM-4GIAJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03966
H3K18ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
abnormality of the oral cavity	HPO Gene-Disease Associations	1.0	null
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10356
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06022
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.65139
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.417562
Hematopoietic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.35
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
molecular layer of the DG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56868
intermediate part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09557
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.244
SRF_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4726-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.17031
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.412
enlarged lung	IMPC Knockout Mouse Phenotypes	1.0	null
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05299
JUN_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.308122
GSE202434,GSE202438_6_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ILKAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35742
H3K79me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.37
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14869
ntera2	HPA Cell Line Gene Expression Profiles	1.0	1.38542
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
required	GeneRIF Biological Term Annotations	1.0	null
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052661
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.48555
hsa-miR-4480	TargetScan Predicted Conserved microRNA Targets	1.0	0.056784
CC-03-PW00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.590121
Methylprednisolone succinate_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.014994
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TP53	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Niclosamide (olamine)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0252098
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tail	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.736
Anterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.95825
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20964
primary motor cortex (area M1, area 4)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13296
molecular_function	GO Molecular Function Annotations 2015	1.0	null
PMC12616242-can-24-3452_supplementary_table_s4_suppst4.xlsx-EWSR1FLI-KDM6A_genes-Genes_associated_to_EWSR1_FLI1-KDM6A_peaks_in_A-673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QDT8-0006-SM-32PL3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27752
U-251MG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.882
496100496_FWM_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.59389
NCIH358	DepMap CRISPR Gene Dependency	1.0	2.00014
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.53448
BC3C	CCLE Cell Line Gene Expression Profiles	1.0	1.94256
Sarcoma_SARC_TCGA-K1-A3PN-01A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A83J-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE184892_6_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.217
ETK-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23102
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.82498
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TFE3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6513
PCI6A	DepMap CRISPR Gene Dependency	1.0	9.93863
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23418
DBTRG05MG	DepMap CRISPR Gene Dependency	1.0	4.47229
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-548ad	TargetScan Predicted Conserved microRNA Targets	1.0	0.082179
GSE118939_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_6_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LS 174T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
f96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.511
PRDM1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4141_KO_Apoe_SRP131850	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.87635
Epimastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.586
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-1826-SM-32PK9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.19352
positive regulation of protein secretion	GO Biological Process Annotations 2023	1.0	null
guanine nucleotide transmembrane transport	GO Biological Process Annotations 2023	1.0	null
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2923
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
A-Vietnam-1203-2004(H5N1)_24Hour_21865398_GSE28166	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.43368
Perturb_6589_KO_Zfp708_SRP186171	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.7514
ELK3-25401928-HUVEC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
RSV_24Hour_19459069_GSE3397	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.66052
HCC366	DepMap CRISPR Gene Dependency	1.0	2.82046
DA-10-GX45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.684351
Entorhinal area, medial part, ventral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12509
BICR18	CCLE Cell Line Gene CNV Profiles	1.0	3.27619
RAGE_knockout_269_GSE22873	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.82557
PCI4B	DepMap CRISPR Gene Dependency	1.0	2.08502
OVCA420	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.39202
hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.325187
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
SIX5_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r5 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63691
GSE213611_1_v_0_nuf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CC-18-YW57_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.444442
ZNF217	ENCODE Transcription Factor Targets	1.0	null
NEUROD2-26341353-CORTEX-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Eye degenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.6927
GTEX-P4QS-0526-SM-2I3ET	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05155
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06567
Lung adenocarcinoma_LUAD_TCGA-69-7974-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.630255
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
hsa-miR-200b	TargetScan Predicted Conserved microRNA Targets	1.0	0.085563
GSE199204,GSE211619_4_v_7_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.862095
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
positive regulation of peptide hormone secretion	GO Biological Process Annotations 2025	1.0	null
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
BA-84-TD72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260863
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323809
GSE236003_0_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
erg_19359602_huvec_lof_human_gpl570_gds3557	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.089121
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_14370_KD_IGF2BP1_SRP131243	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.21792
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.45845
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.921912
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.070973
SB-94-ZA83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.391338
K562_GSK J1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203347
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.85951
TFAP2C-20629094-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
DOHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.968962
Renal tubular transport disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
496100504_TCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0012
GATA2	ENCODE Transcription Factor Targets	1.0	null
XBP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6393
17724462-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GTEx BloodVessel 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	-1.0	-8.99543
GTEX-POMQ-0426-SM-3P61G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957308
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12228
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
locus ceruleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.59588
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4961-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE224311_3_v_1_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
bonemarrow	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.58974
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7365-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
increased pro-B cell number	MGI Mouse Phenotype Associations 2023	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
FOXA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.69441
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
abnormality of the abdomen	HPO Gene-Disease Associations	1.0	null
TFAP2C-20629094-MCF7-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6147-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	0.938695
hsa-miR-193b-3p	MiRTarBase microRNA Targets	1.0	null
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RASIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08334
SIN3B-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12685885-Table1.xlsx-Table_S9-Du_PanCancer_ATF3_SMC_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
ZBTB7A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7253-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
r6 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33581
GTEX-OIZH-1826-SM-2YUNP	GTEx Tissue Sample Gene Expression Profiles	1.0	2.6134
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Astroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.213
Electrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.746
r2 part of anteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.90491
GSE195559_8_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115395_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
K562_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163571
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39278
GSE156708_1_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Capecitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152748
GTEX-XPT6-0326-SM-4B66V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47849
passive transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
8184_SMN2_ENST00000380743.4	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.63758
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.94126
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051227
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3194-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.304
POLR2A_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
iron	GAD Gene-Disease Associations	1.0	null
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.30256
JC-53-YE56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21784
superficial stratum of S	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26092
Male infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.283
Sarcoma_SARC_TCGA-X6-A8C6-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180185_7_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DC-47-KV62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298969
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.98589
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.659888
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PF-59-CY33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.681734
496100327_PCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16995
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83057
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040294
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967586
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03475
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201334
CTCF_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LD-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Field CA3, stratum lacunosum-moleculare	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14953
RAJI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.56109
GSE206516,GSE206518_5_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
isthmic portion of paranigral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12993
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
decrease	GeneRIF Biological Term Annotations	1.0	null
Ribonuclease H2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.824
Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
ATF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G361	CCLE Cell Line Gene CNV Profiles	1.0	1.41694
GTEX-X62O-1626-SM-46MW9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86755
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Epididymal white adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.948
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8325-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39314
SMAD2-18955504-HACAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
HCC1937_BREAST	CCLE Cell Line Proteomics	1.0	2.11221
Leukoencephalopathy with vanishing white matter 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
amygdaloid complex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.831765
SMC3	ENCODE Transcription Factor Targets	1.0	null
DACH1-20351289-MDA-MB-231-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G28T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
SR786	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80726
USF2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7536
r2 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.69318
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHK-1726-SM-3MJFK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58796
APOBEC3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12396
DDX41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47398
edema	MGI Mouse Phenotype Associations 2023	1.0	null
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Glial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.167
17880687-TableS2	GeneSigDB Published Gene Signatures	1.0	null
H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-RNOR-2226-SM-2TF5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21594
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE130676_0_v_2_suds3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8851354-Table_5.xlsx-Ruxolitinib_reg_FD-bound-Supplementary_Table_5_Genes_regulated_by_ruxolitinib_that_are_FUS-DDIT3_targets_in_MLS_402-91_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MN-2526-SM-32PMN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842713
STAT3	ENCODE Transcription Factor Targets	1.0	null
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872752
parvicellular part of Lat	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.75831
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.443
PMC5637904-PATH-243-193-s015.xlsx-human_down_in_ductal_SOX11-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.516313
PMC3607232-mmc3.xlsx-RUNX1_targets_in_K562_and_SEM-x_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TSE9-0526-SM-3DB7Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969353
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85162
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, mouth, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05072
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890086
CCRF-SB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24462
JHU-029	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.94536
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.54554
Mesothelioma_MESO_TCGA-MQ-A4LV-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPARG-20176806-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
AB-71-CI37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.656969
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.781
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.44056
GSE178267_2_v_0_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_9092_KD_HUR_SRP293260	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.5355
designated	GeneRIF Biological Term Annotations	1.0	null
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
DB-24-CQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276743
NCOR1	ENCODE Transcription Factor Targets	1.0	null
GTEX-RTLS-1126-SM-46MUQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841572
GSE230744,GSE237803_5_v_3_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.985012
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C1orf198	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04754
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979986
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84868
Lysosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Pyroptosome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.655
medial part of r7B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09063
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15011
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J6-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE134375_0_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE230744,GSE237803_0_v_3_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
PL21	CCLE Cell Line Gene Expression Profiles	-1.0	-1.94562
monoatomic anion transmembrane transport	GO Biological Process Annotations 2023	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01202
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052682
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NV-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
adenine nucleotide transport	GO Biological Process Annotations 2025	1.0	null
superficial stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44912
ATF3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EB1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04882
GSE249098_1_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	1.0	null
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.99782
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredProteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OIZI-1126-SM-3NB1F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33097
JUN_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865799
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE71468,GSE76476_2_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RUSQ-2026-SM-4GIAK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07891
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40352
CTCF_mammary epithelial cell_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Electric organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.776
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.66296
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZM-0326-SM-4DXUJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19603
FOSL1-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.56156
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.12771
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CUX1	ENCODE Transcription Factor Targets	1.0	null
MA-58-RR04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.358635
17880687-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Syncytium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.272
H3K4ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-X5EB-2626-SM-4E3HZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15173
RUNX2	JASPAR Predicted Transcription Factor Targets	1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29249
BF-10-IO69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.517979
abnormality of the respiratory system	HPO Gene-Disease Associations	1.0	null
Perturb_16512_KD_PAX9_SRP300302	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Coughing	DisGeNET Gene-Phenotype Associations	1.0	null
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Meningitis	DisGeNET Gene-Disease Associations	1.0	null
GSE226355,GSE226357_1_v_0_ybx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-36-TL21_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298324
Retrosplenial area, lateral agranular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08621
Retinal pigment epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.288
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Vascular endothelial cell_Kidney_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
TAGLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74889
golgi apparatus	LOCATE Predicted Protein Localization Annotations	1.0	null
Neutropenia	DisGeNET Gene-Disease Associations	1.0	null
hsa-miR-4319	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
hsa-miR-184	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
family	GeneRIF Biological Term Annotations	1.0	null
UBLC1_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	2.1221
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.498
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962801
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PMC8719356-NIHMS1762846-supplement-2.xlsx-cluster_EC2_x_cluster_EC1-ID_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
developmental process	GO Biological Process Annotations 2015	1.0	null
5588_NEDD8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.707216
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.953385
HO-1-N-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.12955
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24532
COLO-680N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6329-01A-13R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EC-82-LV30_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219496
Aorta cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
Tentacle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.597
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84517
A549_A-366_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148797
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00066
BT20_BREAST	CCLE Cell Line Proteomics	1.0	2.02008
Ligustrazine_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0227049
facial motor nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.25124
Duchenne muscular dystrophy (DMD)_Muscle - Striated (Skeletal) (MMHCC)_GSE1025	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.52744
icSARS CoV_12Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.32724
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.897231
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.93712
thymus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.250953
medial part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05214
NCIH1915	CCLE Cell Line Gene CNV Profiles	-1.0	-2.19876
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17305
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16667
DE-73-JX23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.582842
Nucleus ambiguus, dorsal division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69065
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.92715
USF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6106
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SUP-M2	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.93827
OE-50-VB46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.296369
abnormality of skeletal physiology	HPO Gene-Disease Associations	1.0	null
HA-99-PM50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.498385
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11349
MA-31-VM30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.841207
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NFIC_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DLD-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8T8-0326-SM-3DB93	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09357
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
JUND_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21808
small_intestine	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.07046
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.6672
GTEX-OHPK-1826-SM-2YUMR	GTEx Tissue Sample Gene Expression Profiles	1.0	2.4949
Lung adenocarcinoma_LUAD_TCGA-05-4403-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
QA-58-CX23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.49833
Inferior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50282
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A5RQ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A-VN-1203-2004(H5N1)_Day7-10^3pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.79106
IZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.907674
Cervix disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896714
protein complex	GO Cellular Component Annotations 2015	1.0	null
periventricular stratum of r6Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12427
periventricular stratum of r1Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.92213
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
STK33_knockdown_50_GSE15151	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	3.27192
volume-sensitive anion channel activity	GO Molecular Function Annotations 2023	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZC3H11A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Coronavirus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06711
PE-69-DO79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20962
POLR1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28888
NELFE	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-3977	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
ISTMEL1	DepMap CRISPR Gene Dependency	1.0	2.09599
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.93897
Cerebellum	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.28352
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.92867
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34434
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09921
SSBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11122
GCIY	DepMap CRISPR Gene Dependency	1.0	2.8344
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE168233_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.754194
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.851279
GSE174498,GSE174500_5_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A7U6-01A-12R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE126463_4_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6495_KD_PIEZO1_SRP392492	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Contractile vacuole complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.743
496100516_FWM_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03431
ATF2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-8500-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135030_8_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU620	CCLE Cell Line Gene CNV Profiles	1.0	1.38126
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
17699763-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
NCI-H1793	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.89578
GSE132694,GSE132717_0_v_2_meis1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41442
regulation of myoblast differentiation	GO Biological Process Annotations 2023	1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.857129
PMC6138639-41467_2018_6247_MOESM5_ESM.xlsx-S2_7_ChIP-seq_RNA-seq_overlaps-49_common_elements_in_ZZZ3_bound_and_shZZZ3_Up_genes_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
pc3	HPA Cell Line Gene Expression Profiles	1.0	0.852632
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.05713
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.898895
TCF3	ENCODE Transcription Factor Targets	1.0	null
2793_EXOSC6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.42219
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2562
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
talrrp	GeneRIF Biological Term Annotations	1.0	null
MTFR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31082
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
dorsal lateral geniculate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12512
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XGQ4-1526-SM-4AT6H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973231
b cell deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.997392
GTEX-SNMC-0526-SM-4DM69	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871641
hsa-miR-4650-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.065994
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.978436
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24351
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6599
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3217_KO_Stat1_SRP271755	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.54982
cyclic nucleotide transport	GO Biological Process Annotations 2023	1.0	null
MCF7_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146297
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UJMC-0626-SM-4IHJQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.969019
miR-targeted genes in muscle cell - TarBase(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MT-0011-R6a-SM-2I3G3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862394
GTEX-OHPL-1826-SM-2YUN8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34216
mantle zone of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19947
GSE173394_1_v_0_nfatc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SRF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.46858
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9314667-Table_1.xlsx-Regulons-HES6_HES6	Rummagene Transcription Factor Associations 2026	1.0	null
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.46
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34034
SRF_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25574
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73271
SARS-CoV_12Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.55339
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.283
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intestine-407 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.397
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32405
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
PRECLH	CCLE Cell Line Gene Expression Profiles	1.0	1.36081
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE169356_2_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BF-26-MB27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242318
transverse gyri, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.866129
TCF12_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2203_DHX15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.666485
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.27939
PMC12703482-AMS-21-5-213605-s2.xlsx-Supplementary_Table_SXV-SMR_results_of_expression_levels_of_VDR_target_genes_in_peripheral_blood_and_risk_of_hepatocellular_carcinoma_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.969424
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-33a-5p	MiRTarBase microRNA Targets	1.0	null
decreased T cell proliferation	MGI Mouse Phenotype Associations 2023	1.0	null
fasciola cinerea	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21955
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25552
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GATA2_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.456
ae2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.354
MCF7_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153121
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.97176
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX5	ENCODE Transcription Factor Targets	1.0	null
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.413
GTPBP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01192
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-765	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
DB-56-XL71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207595
Lung squamous cell carcinoma_LUSC_TCGA-58-A46N-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KB cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.37
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927255
NRF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.986182
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
AB-32-WM54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349681
abnormal embryo size	IMPC Knockout Mouse Phenotypes	1.0	null
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RO-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hypotonicityinduced	GeneRIF Biological Term Annotations	1.0	null
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.729
GTEX-RUSQ-0626-SM-2TF5V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828972
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.995335
PRXL2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80112
GTEX-U8T8-2226-SM-3DB95	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42119
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
ELF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-NPJ8-1926-SM-3MJGB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5621
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-A5NK-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1944	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.63768
r7 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05214
GSE240444_2_v_3_idasanutlin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26909
r3 part of anteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71009
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_3hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
midbrain raphe nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01705
PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
7649_SAP30BP_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.561568
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.239307
Adagrasib_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0222663
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-4.12845
KATOIII	CCLE Cell Line Gene Expression Profiles	1.0	1.49588
SP4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
oral mucosa	HPA Tissue Protein Expression Profiles	-1.0	-3.26937
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VV-A829-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
X-linked agammaglobulinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.991
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_7_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11785
abnormality of the face	HPO Gene-Disease Associations	1.0	null
Agammaglobulinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.146
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38537
regulation of insulin secretion	GO Biological Process Annotations 2023	1.0	null
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985014
pre-B cell differentiation	GO Biological Process Annotations 2025	1.0	null
GSE128333_4_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136591
inner SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.84563
hsa-miR-4329	TargetScan Predicted Conserved microRNA Targets	1.0	0.072324
CE-18-CG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216531
intermediate stratum of r7BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07332
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73352
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
rnf2_21051595_92dot1_lof_human_gpl10558_gse24896	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.134341
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.883823
CE-19-PD79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308382
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZD-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20U-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.871099
DACH1-20351289-CHIP-SEQ-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CREB1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
monoatomic ion transport	GO Biological Process Annotations 2023	1.0	null
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.82562
ED-02-CL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.956533
PD-71-MW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.567586
GSE239844_11_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.895916
Breast_vHMEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.29021
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052276
hsa-miR-607	TargetScan Predicted Conserved microRNA Targets	1.0	0.123298
Perturb_9091_OE_HUR_SRP293260	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.4573
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2726
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4189
TAF1	ENCODE Transcription Factor Targets	1.0	null
Osteoclastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.186
1127_C8ORF76_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.695695
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE223908,GSE223909_4_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.03525
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3434-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5451-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABA-A receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.27
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25214
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-652-ENSG00000196152_ZNF79	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13467
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23134
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE203329_2_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-88-WQ63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236962
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-PAX6_UNIQUE_DYS_GENES-PAX6_TLE_vs_TL_log2FoldChange_1_padj_0_1_PAX6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154577_2_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TFCP2L1	ChEA Transcription Factor Targets	1.0	null
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.932977
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.5464
HCC89	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00739
hsa-miR-208b	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82693
infertility	MGI Mouse Phenotype Associations 2023	1.0	null
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
GTEX-QVJO-0526-SM-447CE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91229
K562_Rigosertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148678
estradiol_homo sapiens_gpl1225_gse1486	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-NEUN_UNIQUE_DYS_GENES-PAX6_TLE_vs_TL_log2FoldChange_1_padj_0_1_PAX6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-REY6-0726-SM-2TF4M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27627
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
DHPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57021
Perturb_15897_KD_GLI1_SRP241956	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.7155
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28032
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QCQG-0326-SM-2I3ES	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918562
PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR	Rummagene Transcription Factor Associations 2026	1.0	null
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CTBP2	ENCODE Transcription Factor Targets	1.0	null
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F4_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4652-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
JURLMK1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.05595
NCIH1755	DepMap CRISPR Gene Dependency	1.0	3.7301
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290476
SPI1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49546
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
18691415-Table5f	GeneSigDB Published Gene Signatures	1.0	null
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NTERA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.836989
ATF	MotifMap Predicted Transcription Factor Targets	1.0	null
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREBBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NP2	DepMap CRISPR Gene Dependency	1.0	2.12809
GSE60217_1_v_2_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SF767	CCLE Cell Line Gene Expression Profiles	1.0	1.58156
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Frt	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.076
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
UACC812	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.09056
HKGZCC	DepMap CRISPR Gene Dependency	1.0	2.13595
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01421
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02864
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.18505
Ebf2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.7845
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE229671,GSE229673_0_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.3476
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505358
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUN	ENCODE Transcription Factor Targets	1.0	null
Perturb_8994_KD_CCDC144NLAS1_SRP135858	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
COLO 206F	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.950365
hsa-miR-3176	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
lrrc8like	GeneRIF Biological Term Annotations	1.0	null
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
PMC8755441-main.nxml--IRF3_KO_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
H2AK5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
r8 part of the paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44989
A549_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164469
TET2_KO_GDS4287_429_mouse_LSK - bone marrow progenitor population	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
hacat	HPA Cell Line Gene Expression Profiles	1.0	2.19073
Astrocyte projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.276
abnormality of the skull	HPO Gene-Disease Associations	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cell surface	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
TBX5	ChEA Transcription Factor Targets	1.0	null
18081427-TableS8	GeneSigDB Published Gene Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IY-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05134
GSE205976,GSE205978_1_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
SMAD2-18955504-HaCaT-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203017
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917124
GTEx Uterus 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-3.74351
Primary somatosensory area, nose	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16141
purine ribonucleotide transport	GO Biological Process Annotations 2025	1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
mantle zone of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08781
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.67398
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal joint morphology	HPO Gene-Disease Associations	1.0	null
FE-29-XM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.427933
OCI-AML5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.317
GSE131649_2_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HDAC2_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Chlorhexidine (diacetate)_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0246215
PXR (PXR:RXR)	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MO-1926-SM-32QOJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75517
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
Bronchial epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.729
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.41974
HS766T	CCLE Cell Line Gene Expression Profiles	1.0	1.89677
GTEX-W5X1-0826-SM-3GILN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904793
Prostate adenocarcinoma_PRAD_TCGA-VP-A87D-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Congenital Epicanthus	DisGeNET Gene-Disease Associations	1.0	null
Megalencephalic leukoencephalopathy with subcortical cysts	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.558
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Amelanotic melanoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.649
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
member	GeneRIF Biological Term Annotations	1.0	null
GSE229468,GSE229471_2_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
lysosome	GO Cellular Component Annotations 2025	1.0	null
Copper ion transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.985
Perturb_12524_KD_Linc00673_SRP212104	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
DC-22-OP01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.375509
Hypb_Deficiency_GDS3641_523_mouse_Yolk sac from E10.5 embryos	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.58942
anion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
Testicular cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.688
DNM1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41156
GSE102870_7_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ebolavirus(EBOV)_3day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.25192
LOVO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.31932
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.584
CREB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6929
intermediate part of r7B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21788
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12917211-Table1.xlsx-Table_S13-Table_S13_Gene-level_perturbation_statistics_from_the_virtual_KLF5_knockout_model_in_malignant_ductal_cells_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KPL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.99909
MDAMB134VI	CCLE Cell Line Gene Expression Profiles	-1.0	-2.89755
abnormality of temperature regulation	HPO Gene-Disease Associations	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PML	ENCODE Transcription Factor Targets	1.0	null
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
motor nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06228
AD-99-SN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.704293
agammaglobulinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.09167
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.1709
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_9-Supplemental_Table_9_Limma_DE_Analysis_of_HC_AA_to_EA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
FOXA1-26457646-LHSAR-HUMAN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.66809
mantle zone of r9BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09416
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QLQ7-0926-SM-447BC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954375
lateral hemisphere of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10926
NOZ	DepMap CRISPR Gene Dependency	1.0	6.1419
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-7941-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dentate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07107
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247249
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
CAL-148	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.49736
LD-69-ZV56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.579923
SPI1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.738346
BC-15-MR23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.28546
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_24Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.20148
GTEX-RTLS-0526-SM-2TF64	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903906
6377_PISD_ENST00000266095.5	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.628883
CB-02-XL81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.406586
GSE193993_5_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.37271
GTEX-XQ3S-1126-SM-4BOPK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12002
GSE148269,GSE148273_0_v_1_arid4b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970551
EP300_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
external ear malformation	HPO Gene-Disease Associations	1.0	null
MYCN	ChEA Transcription Factor Targets	1.0	null
Perturb_13653_KD_CELSR2_SRP149837	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.7341
GSE60217_1_v_8_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hallermann-Streiff syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
monoatomic anion channel activity	GO Molecular Function Annotations 2023	1.0	null
DIRAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09922
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
16715129-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
CHK1_KD_GSE54267_672_human_U2OS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8D-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_WT_3T3_ONLY_1626_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
periventricular stratum of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58197
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.41135
GTEx Uterus 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-11.8582
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.947945
Adrenocortical carcinoma_ACC_TCGA-OR-A5J5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
decreased DN4 thymocyte number	MGI Mouse Phenotype Associations 2023	1.0	null
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RU-01A-31R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-00-YH62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.380232
TEAD4	ENCODE Transcription Factor Targets	1.0	null
GTEX-S4P3-1126-SM-4AD52	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864844
abnormal thymus apoptosis	MGI Mouse Phenotype Associations 2023	1.0	null
Nafamostat (mesylate)_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00867316
nucleus of diagonal band	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19003
Lung squamous cell carcinoma_LUSC_TCGA-22-4609-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
recurrent infections	HPO Gene-Disease Associations	1.0	null
abnormal T cell physiology	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-R55C-1826-SM-3GADI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07337
MCF7_Ramelteon_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015046
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896714
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09788
Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TG-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932652
ZNF143	ENCODE Transcription Factor Targets	1.0	null
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
Pitavastatin (Calcium)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0294584
superficial stratum of ERCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04815
PMC9105874__F2	PFOCR Pathway Figure Associations 2024	1.0	null
cyclic-GMP-AMP transmembrane import across plasma membrane	GO Biological Process Annotations 2025	1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02992
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Temporal lobe epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94944
EBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lysosomal membrane	GO Cellular Component Annotations 2023	1.0	null
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06333
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Clouston syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
YY1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-0944-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-RWS6-0426-SM-47JXH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06619
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30209
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2889-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894108
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8858874-NIHMS1764275-supplement-Supplemental_Table_2.xlsx-R1_SOX2_bound_genes_5000bp_6-9--Nearest_Ensembl_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
HSC3	DepMap CRISPR Gene Dependency	1.0	3.11878
C-4-I	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_Givinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143254
m1 part of paranigral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02107
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HC-89-WQ85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223223
GATA2_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TP63_01_330	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.62433
Primary visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00426
intrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.118458
abnormality of the palate	HPO Gene-Disease Associations	1.0	null
absent corpus luteum	MGI Mouse Phenotype Associations 2023	1.0	null
POLR2AphosphoS2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.124
LY-2584702 (tosylate salt)_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00968101
Retinal pigment epithelium cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.162
GTEX-QVJO-1325-SM-2S1QX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943446
Pinosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.355
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulatory	GeneRIF Biological Term Annotations	1.0	null
Endolysosome lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.618
hsa-miR-3191	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
K562	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.983533
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12361
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21745
Hypothyroidism	DisGeNET Gene-Disease Associations	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.666
AC-36-TL21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264744
abnormality of b cell physiology	HPO Gene-Disease Associations	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vacuolar membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BPAEC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.541
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0426-SM-3NB31	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62757
ELK4	ENCODE Transcription Factor Targets	1.0	null
DB-69-JG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286426
abnormality of the orbital region	HPO Gene-Disease Associations	1.0	null
GSE239844_6_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETS1_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r9BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50282
MDA-MB-361	COSMIC Cell Line Gene Mutation Profiles	1.0	null
named	GeneRIF Biological Term Annotations	1.0	null
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.363
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04194
abnormality of the skin	HPO Gene-Disease Associations	1.0	null
GSE96649_1_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.503
GTEX-XGQ4-2426-SM-4AT55	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42035
Anterior pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04562
BE-42-IC00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.843806
PANC0213	CCLE Cell Line Gene CNV Profiles	1.0	1.43772
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-8314-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of PCPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53957
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981667
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.9545
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992819
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
rt1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.504
GSE196259_2_v_3_gcm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
igr37	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.003
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.197
ATPase inhibitor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.818
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE203017_0_v_1_irs2_human	RummaGEO Gene Perturbation Signatures	1.0	null
AA-52-JS03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.436021
SRF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
b cell activation	GO Biological Process Annotations 2015	1.0	null
layer 1 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.7588
Liver hepatocellular carcinoma_LIHC_TCGA-LG-A6GG-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
m2 part of paranigral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00498
GSE229671,GSE229673_3_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205817
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.896714
adenine nucleotide transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929191
LAMA84	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78878
GTEX-V955-0926-SM-4JBJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13168
PMC4029819-pone.0098069.s006.xlsx-Sheet1-Table_S5_FSS_analysis_of_FOXA1_high_versus_FOXA1_low_cases_in_metastases_p-value_0_01_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.876432
BC-00-YH62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.355259
immature B cell differentiation	GO Biological Process Annotations 2025	1.0	null
GTEX-N7MT-1226-SM-2D7W4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62542
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
YA-44-LW45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.527727
ATF3	ChEA Transcription Factor Targets	1.0	null
abnormality of the eyelid	HPO Gene-Disease Associations	1.0	null
LS-411N	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-5.73026
ZBTB33_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TSC22D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12468
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	3.2272
A549_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154947
Perturb_16312_KD_SF3B4_SRP349464	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Ehrlich ascites carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.812
r1 part of vestibular nucleus Y	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.91269
hsa-miR-378g	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.858769
Brain Lower Grade Glioma_LGG_TCGA-HT-7616-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPP1CC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41555
FD-62-ZB67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.48214
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5557-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
XE-69-AT35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351397
GSE186633_1_v_0_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE197555_0_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.368
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal craniofacial morphology	IMPC Knockout Mouse Phenotypes	1.0	null
GSE178340_5_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.594
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.00215
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19286
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283274
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLI1_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE131649_4_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XXEK-1226-SM-4BRUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29013
IRAK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3431
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06837
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12196
hsa-miR-4741	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
hsa-miR-149-5p	MiRTarBase microRNA Targets	1.0	null
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05604
Failure To Thrive	DisGeNET Gene-Disease Associations	1.0	null
B800-820 antenna complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.818
Lung adenocarcinoma_LUAD_TCGA-78-8655-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C-127 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.675
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239688_2_v_5_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE251992_1_v_0_saracatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
decreased thymocyte number	MGI Mouse Phenotype Associations 2023	1.0	null
GSE234289_4_v_1_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_8_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-570	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GT-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HA-E2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Taste bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.093
SIX5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
otitis media	HPO Gene-Disease Associations	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.464366
KSR1_knockout_126_GSE28228	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.25622
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01512
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of DG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64011
HCC2998	DepMap CRISPR Gene Dependency	1.0	2.29269
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.826337
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE134375_6_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09279
GSE231891_3_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
olfactory part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.47307
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.49011
Pulmonary artery endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.314
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PC-18-VX23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.14877
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181424
AFMID	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53602
B800-850 antenna complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.833
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.76361
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4QS-0426-SM-3NMCQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61744
HCV JFH-1_48Hour_20200238_GSE20948	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.31294
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.423
GSE196259_1_v_3_gcm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1934
membrane	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22274
Relugolix_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0230505
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7284-01B-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SYK_druginhibition_287_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.33986
Omeprazole (sodium)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00631532
Hypertrophy	CTD Gene-Disease Associations	1.0	1.45063
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6937
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.79925
a24	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.342
brain_3b	HPA Tissue Sample Gene Expression Profiles	1.0	3.42284
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146982_3_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Dehydration	DisGeNET Gene-Phenotype Associations	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
10min_PPase_inhibitors vs ctrl_Hepa1-6 (Mouse) [18846507]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs	1.0	null
mantle zone of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05214
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16087_KD_Pml_SRP306364	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.78497
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.27329
Combined immunodeficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
DB-40-HA40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.366566
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
postnatal growth retardation	MGI Mouse Phenotype Associations 2023	1.0	null
GSE178532_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
IST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11151
NRF1	ENCODE Transcription Factor Targets	1.0	null
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08099
GSE131649_4_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ChIP_KLF4_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7518_KD_TRDMT1_SRP217219	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.39362
Entorhinal area, medial part, ventral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05769
UTP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31829
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01087
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UE-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DA-27-BW20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225709
hsa-miR-648	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
AE-11-VB80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212469
AD-54-FG24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.523078
Primary somatosensory area, barrel field	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1855
JUND_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
morphological abnormality of the central nervous system	HPO Gene-Disease Associations	1.0	null
CSR_EARLY_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872136
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.510828
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28-19339689-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOSL2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETCC016	DepMap CRISPR Gene Dependency	1.0	4.07257
17286852-Table2	GeneSigDB Published Gene Signatures	1.0	null
JD-12-YK78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.313684
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.59689
dorsolateral part of Lat	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36611
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.875936
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976219
localized skin lesion	HPO Gene-Disease Associations	1.0	null
Perturb_16563_KO_Atf4_SRP320716	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.98244
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5324-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148488
Arthritis	DisGeNET Gene-Disease Associations	1.0	null
GSE230646_0_v_2_rbpms_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992417
Perturb_11640_KD_ITCH_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.26941
GTEX-RUSQ-1926-SM-2TF6K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09702
generalized abnormality of skin	HPO Gene-Disease Associations	1.0	null
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.197
SFTPC_KO_GDS4876_476_mouse_Lung Type II cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
EGR1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Medroxyprogesterone acetate_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0238175
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
REST_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
estradiol_mus musculus_gpl4134_gse23241	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JC-67-FV32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298122
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959116
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2641
FB-39-CW59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273016
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39427
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6417
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42773
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3RC-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CREB	MotifMap Predicted Transcription Factor Targets	1.0	null
SNU308	CCLE Cell Line Gene Expression Profiles	1.0	1.35545
doxorubicin_homo sapiens_gpl10558_gse42531	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.55846
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TE-32-AC63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.528982
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868352
GSE168171,GSE168173_0_v_1_ddx41_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-15-EL49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.540828
Pulmonary artery endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.601
TAF7	ENCODE Transcription Factor Targets	1.0	null
volume	GeneRIF Biological Term Annotations	1.0	null
GTEX-XMD1-2826-SM-4AT5F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88743
Brain Lower Grade Glioma_LGG_TCGA-VW-A7QS-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
all	HPO Gene-Disease Associations	1.0	null
NCI-H650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
XRK3F2_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0123946
GSE149359_3_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_17548_KD_HMGN5_SRP354633	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
AB-01-NB05_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243327
GSE146982_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
X-linked recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.432
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.01565
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J8-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
GSE60217_1_v_10_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SP1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inflammatory abnormality of the eye	HPO Gene-Disease Associations	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.81
Posterior parietal association areas, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28059
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4326
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Agammaglobulinemia	CTD Gene-Disease Associations	1.0	2.88009
SP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14472
KB-3-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.818
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_11363_KD_TMEFF2_SRP302699	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.181
HNF4G_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46902
GSE248935_1_v_0_cd14_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE215086_5_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-125a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.111118
CREB1	ENCODE Transcription Factor Targets	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-3909	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE171572_3_v_4_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
skeletal muscle	HPA Tissue Protein Expression Profiles	1.0	1.99325
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.879734
PMC4123081__F4	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34304
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
aspartate transmembrane transport	GO Biological Process Annotations 2025	1.0	null
BB-42-FF52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2009
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE223908,GSE223909_1_v_3_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.939917
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JIMT1_BREAST	CCLE Cell Line Proteomics	1.0	5.83988
Perturb_5354_KO_Dux_SRP201141	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.5961
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7415-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8047442-EMBJ-40-e105492-s003.xlsx-MR_plot_analysis-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE115542_5_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WYBS-0426-SM-3NM9M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27376
16651409-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169590_0_v_5_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE261177_0_v_1_tnfrsf12a_human	RummaGEO Gene Perturbation Signatures	1.0	null
meningitis	HPO Gene-Disease Associations	1.0	null
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SIN3A	ENCODE Transcription Factor Targets	1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1562
Phellem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Synaptic cleft	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.151
GSE207135_1_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE188382_4_v_0_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
SRF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1	ENCODE Transcription Factor Targets	1.0	null
XB-53-OZ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202966
PMC13127299-mmc2.xlsx-FOXM1_kdRNAseq-hgnc_symbol_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.88332
A427	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.33375
SNU1041	CCLE Cell Line Gene Expression Profiles	1.0	1.48092
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933275
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4749-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
mantle zone of S	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25995
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63102
Connexin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.049
LXF-289	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01087
fibroblast	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AB-53-AW00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20484
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18506
GTEX-OOBJ-1826-SM-3NB1C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979889
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271105
H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3955
Brain infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
PMC6305442-Table_1.docx-0-IKZF1_IKZF1	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
P2URK562	DepMap CRISPR Gene Dependency	1.0	3.44007
GSE207611,GSE207612_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.492549
NCI-H1155	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE234289_3_v_1_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10645393-jci-133-169200-s102.xlsx-Table_S14_AR-V_DNA-PK_DEGs-Supplementary_Table_14_Overlapping_DEG_list_from_CWR22Rv1-AR-EK_cells_depleted_of_AR-V7_and_treated_with_DNA-PK_inhibitor_NU5455_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
r2 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.01679
EGR1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ND-39-PO34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.464103
other	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-670	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.62976
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.63347
Pancreatic adenocarcinoma_PAAD_TCGA-FB-A545-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.98626
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-OXRP-0926-SM-48TC1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00145
Lung adenocarcinoma_LUAD_TCGA-55-8089-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
B cell deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.029
response to stimulus	GO Biological Process Annotations 2015	1.0	null
NR2F2	ENCODE Transcription Factor Targets	1.0	null
Lung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.987797
STAT3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_H3K36me3_18692474_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CB-32-EI69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.26113
KCTD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05756
r10 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04599
PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.91832
hypogammaglobulinemia	HPO Gene-Disease Associations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A3IB-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH211	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46706
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.348
Megalencephalic Leukoencephalopathy	DisGeNET Gene-Disease Associations	1.0	null
TAL1-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Avian pallium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.124
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.957725
MCF12A	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.997927
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.69756
CPC-N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
OA-80-YT10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306095
SF3B3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53129
hsa-miR-4324	TargetScan Predicted Conserved microRNA Targets	1.0	0.062888
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CG-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.945195
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Embryonic kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.724
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DJ-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128333_3_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF577	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15646
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.409725
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Posterior parietal association areas, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03967
hsa-miR-3922-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49301
small thymus cortex	MGI Mouse Phenotype Associations 2023	1.0	null
E2F4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE119603_1_v_0_oxaliplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ES5	DepMap CRISPR Gene Dependency	1.0	3.21755
YWHAZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42259
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5690-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYBL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.686