association	dataset	threshold value	standardized value
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PCCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44838
PRAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11753
GSE193258,GSE193259_2_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Electron transfer flavoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.637
LEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28443
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.568
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.203
LRRC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23599
JMJD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27113
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	103.395
GSE175787_5_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EPB41L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97883
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.493
RHOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92389
hsa-miR-4639-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9399
Euchromatin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.155
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1225
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.835926
GSE223893_2_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63789
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.66085
PMC3526425-1471-2164-13-572-S3.xlsx-STAT6-STAT6_STAT6	Rummagene Transcription Factor Associations 2026	1.0	null
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5667
DD-74-PJ26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201742
CRCGN014_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4749
PHETA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89823
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202347
CRCGN012_HEPG2_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12453
GSE119978,GSE180930_0_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1414
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2706
OKF-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.76
PPARD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19772
KARPAS-422 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.558
Cutaneous Melanoma	DisGeNET Gene-Disease Associations	1.0	null
Nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.44
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SELENOI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41635
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
DVL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52389
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Squamous Cell Carcinoma Of Oropharynx	DisGeNET Gene-Disease Associations	1.0	null
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.20466
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18489
GSE238018_1_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CNFN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04028
AE-13-CX28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202342
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.835926
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00954
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
CRCGN017_MCF10A.WT.HP_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03585
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
Peritubular contractile cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.627
Hepa-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
Intraocular melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.342
SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9064
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.958976
Head and neck carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.312
CRCGN016_MCF10A.TP53.M_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08903
CREM	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9142
Nuclear lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00954
BLOC1S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68749
PRKCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5802
GSE193258,GSE193259_5_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1705
RCOR1_02_204	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61305
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.445
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.958
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.20298
COPS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15546
Multiple myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.52
RGL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74888
RNF40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00259
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217071
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
skin	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE162623_0_v_1_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NR2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
Colon carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
CARHSP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15493
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.90607
A-375 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.734
Nuclear body	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
RPL22L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77984
GSE110802_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
blood	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GLRX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98101
Stage, Esophageal Cancer	DisGeNET Gene-Disease Associations	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.817
CRCGN012_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.79265
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PANC 05.04	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847348
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6618
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AP4M1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66808
Melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.766
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8568
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-SUPPLEMENTARY_TABLE_12_Bulk_RNA-seq_results_of_invasive_fractions_from_GBM43_CTH_knockdwn_vs_GBM43_control_cells_invading_3D_hydrogels_AR	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4775	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
SNU-475 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.599
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8151
RASGEF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98537
u26684	HPA Cell Line Gene Expression Profiles	1.0	0.859051
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.726
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
KCNIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27456
GSE153443_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
hl60	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
MHC class I peptide loading complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.018
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02091
Head and neck squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.272
MAGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67604
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
ZNF784	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.96256
ZNF461	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42581
GSE140997_10_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.28655
NUDCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88885
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
LACTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99515
MAP3K12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62414
TEAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79216
TFAP2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.258
Papillary Thyroid Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
hek293	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
nucleoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.162
ct96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.808
LDHA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70549
Nephroblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5875
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19301
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.552
PMC7300082-41598_2020_66556_MOESM11_ESM.xlsx-Supplementary_Table_10-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
Renal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.284
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.61895
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.239
CRCGN012_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8705
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23562
PML body	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
496100600_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.76703
HNRNPLL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21709
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.835926
SHOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02157
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.983395
UXT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36213
GSE140997_2_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pachytene cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.523
ATP6V0D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23053
CENPU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05935
gl6	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.546
GSE202825_2_v_1_ano1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
NFKB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63827
DCLRE1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82504
GSE238018_1_v_2_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JDP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9521
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6887
PMC4498179-srep11671-s1.pdf-117-ZNF99_ZNF99	Rummagene Transcription Factor Associations 2026	1.0	null
Cellular bud neck	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.083
PRELID3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11171
CRCGN010_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.35374
CRCGN017_MCF10A.WT.HP_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14245
MTHFS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15163
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23875
CRCGN017_MCF10A.WT.HP_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0146
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.834841
PMC11568168-41598_2024_79607_MOESM3_ESM.xls-11-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
Conventional (Clear Cell) Renal Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.497
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4669
CRCGN010_HEPG2_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03854
SETBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15779
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.65102
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.4325
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
Endodermal sinus tumor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.7373
Oral squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.79
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.949
Septin ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.061
Cellular anatomical entity	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sensory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
TSTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59125
GSE57871_5_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GATA2	ENCODE Transcription Factor Targets	1.0	null
GPR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64885
NUDT16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57288
GSE175787_11_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CLDN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18135
Cell envelope Sec protein transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.503
CRCGN013_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03671
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
hsa-miR-466	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Esophagus - Gastroesophageal Junction	GTEx Tissue Gene Expression Profiles 2023	1.0	7.21239
hsa-miR-940	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Ectc	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.522
GSE142210_2_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Myeloid neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.484
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218122
CCDC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37958
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2755
RNPEPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.587
Apoptotic body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.341
CRCGN017_MCF10A.WT.HP_24H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5255
TM9SF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34906
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.317278
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1366
Male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.213
IFT52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32121
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41016
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.659
LIMD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63797
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Laryngeal squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.693
KLLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70632
GJA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32838
Cellular bud neck septin structure	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.288
BEX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01618
LOU-NH91	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.990068
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205125
496100548_HIP_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0188
PMC8040704-jcav12p2673s2.xlsx-Down-regulated_genes_in_EBF1-Unnamed_0_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6639357-41467_2019_11150_MOESM4_ESM.xlsx-SupTab1_Activated_genes_diffex-Supplementary_Data_1_Fold_change_and_p-value_of_all_activated_protein_coding_genes_upon_DNMT1-KO_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
HCC89	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05926
CHAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63885
GSE240386,GSE242143_1_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-876-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.655
hsa-miR-3942-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.542
Integral component of endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.975
NBDY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.31018
colo800	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.671
Urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.533
RAB3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.43274
Organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Bronchial cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.501
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.147
JAK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61152
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263502
CRCGN011_HEPG2_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23005
nuclear body	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02576
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
GSE164505,GSE164506_3_v_1_indisulam_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GALK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31622
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.442
RMDN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68678
intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Germ cell and embryonal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
TRAM1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14098
Gin4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.288
CRCGN016_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04917
Esophageal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.31
celecoxib_homo sapiens_gpl8300_gse11237	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1774
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.494
PMC11385078-jciinsight-9-172336-s272.xlsx-1DEseq2_Report_AA_BL_vs_EA_BL-Unnamed_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
nb4	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
mcf7	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.350842
TRIT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48413
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23487
NADK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07369
hsa-miR-216a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.356989
PMC12240782-Table3.xlsx-Sheet1-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
Intrinsic component of endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.975
GSE111247_14_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214685_0_v_1_nsun2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE221327_4_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Integumentary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.352
PMC5055179-CAM4-5-2522-s008.xlsx-S1-Supplementary_Table_S1_Properties_of_genes_upregulated_by_MBD-TET1-CDwt_TET1	Rummagene Transcription Factor Associations 2026	1.0	null
PIAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46308
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.26336
ATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5194
HMGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98031
MCM8-MCM9 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.166
ATP2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.50634
PEAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0507
Oral squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
Prostate Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2684
BMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44319
GSE229973_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AGO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.046
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312617
Groin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.659
PCMTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51827
7td1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.561
FNBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55131
CRCGN017_MCF10A.WT.HP_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12885
hsa-miR-98-5p	MiRTarBase microRNA Targets	1.0	null
hsa-miR-4504	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
IGFBPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6322
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.83043
Transitional cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
bexarotene_homo sapiens_gpl96_gds2777	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24885
organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.983395
TMEM81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32751
DNMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85424
IC-05-AW29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.38317
NAT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04823
Kidney Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242290_3_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.641
HAX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58128
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5749
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	230.818
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
LARP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45171
GSE230573_1_v_0_dcaf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DD-74-PJ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.389142
GSE193258,GSE193259_5_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-445-HSFX1_HSFX1	Rummagene Transcription Factor Associations 2026	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MYEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94728
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7298
SK-MEL-37 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.819
STX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58748
TBX20	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0644
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.676
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.908661
ADCY9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51073
CRCGN015_MCF10A.TP53.M_24H:E24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03395
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13124
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18404
Myelodysplastic syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
GAL3ST3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.20009
USP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64226
Septin cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.964
deferasirox_homo sapiens_gpl570_gds3558	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SNU-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.913974
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
HILPDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39002
Intracellular anatomical structure	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220824
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9553
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2827
B3GALT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87603
CNEP1R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6736
Melanoma	DisGeNET Gene-Disease Associations	1.0	null
Sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.431
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.5637
hsa-miR-31	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
hsa-miR-4499	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
FOXR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82707
JY cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.73
CRCGN017_MCF10A.TP53.M_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27207
KP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1615
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.7383
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226948
CRCGN016_MCF10A.WT.HP_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13056
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.83518
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.8209
CRCGN008_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8579
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09803
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33462
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00874
Embryonal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.427
I-kappaB/NF-kappaB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.715
Melanoma associated antigen, MAGE, N-terminal	InterPro Predicted Protein Domain Annotations	1.0	null
WDR76	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56202
Lymphoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.591
Tonsillar Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Seminoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.433
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.913974
Leukocyte disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.402
NAALADL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47151
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2898
RPS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4681
GSE139540_0_v_1_menadione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314326
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0587
GSE150072,GSE169209_6_v_11_qser1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.2823
GSE125862_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.816
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1429
GSE221327_5_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29469
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23562
GSE131649_6_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216273,GSE216292_14_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF354B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55048
H2BC26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62887
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.476
GSE200839,GSE233826_2_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
SK-MEL cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.724
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Connective tissue cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RNF182	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38815
CRCGN017_MCF10A.WT.HP_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15595
POLQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85922
Small Cell Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
Embryonal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.416
CHST14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80115
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-ensembl_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6235
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5078
hsa-miR-3167	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
NHBE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.51
T2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.232
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.308835
ATF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8676
Oral cavity cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
LHX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61447
GSE127261_1_v_2_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.606
Skin cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.762
GSE240386,GSE242143_1_v_4_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160765_2_v_1_twist1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Synovial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.785
CRCGN015_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29321
SK-MEL-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.735
CRCGN014_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07845
LCLC-97TM1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.8601
Cytotoxic T-lymphocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.852
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21577
GSE163297_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CENPJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62373
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9119
Oropharynx (Excludes Nasopharynx)	DisGeNET Gene-Disease Associations	1.0	null
GB-57-XV52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205568
PDZD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8817
NRF1_02_62	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59422
PRDM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32539
RANBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70862
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
TMEM167A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56988
GSTZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22583
nucleoplasm part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CRCGN014_HEPG2_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44463
FOSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4719
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Aorta smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.589
Secondary Malignant Neoplasm Of Lymph Node	DisGeNET Gene-Disease Associations	1.0	null
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7532
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.55466
THRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.699
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.55605
RALGAPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83676
OVCA 429	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.939019
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
GSE229973_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
GAMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58247
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.20777
MRPL20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8438
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33548
NALF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66503
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7631
GSE235550_2_v_0_hspa9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0582
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3957
CAPAN-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.571
CRCGN016_MCF10A.WT.HP_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71836
Plasma membrane respirasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.536
TMEM250	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5837
CRCGN017_MCF10A.WT.HP_24H:F24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32115
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01719
MAGE homology domain	InterPro Predicted Protein Domain Annotations	1.0	null
hsa-miR-590-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
496100352_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.24193
ZNF572	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23744
GOLM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63961
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.913974
AC-30-XU83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236414
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223402
Germ cell cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.423
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.737
FOS	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE145682_1_v_0_nbdy_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Spermatoproteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.617
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.8601
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.437
ATAD3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.45112
nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
klf4_17017123_rko_gof_human_gpl96_gds1942	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.575032
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
ETV5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05633
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09803
hsa-miR-4427	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Laryngeal squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.506
Spear	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.535
CRCGN008_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54045
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.36434
TRAF3IP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57659
Skin melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.415
GSE223893_11_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ARC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74575
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227464
SUPT7L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65541
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4648
Laryngeal benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.263
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00954
CTCF	ENCODE Transcription Factor Targets	1.0	null
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4049
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352657
PMC3290552-pone.0032232.s006.xls-MUC4-KD_vs_Mock-Unnamed_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
Esophageal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
RNF41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7077
hsa-miR-549	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Gonad	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.373
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.9229
colo857	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.145
CRCGN017_MCF10A.WT.HP_24H:N18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1618
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
Stomach carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.297
hsa-miR-548p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Testicular cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
POLR2A	ENCODE Transcription Factor Targets	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.166
CBY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97427
MDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44617
hsa-miR-4789-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313713
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.086
NPPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09419
NarGHI complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.546
Cataract 37	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
MC-30-BS07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258894
Intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.567
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.7179
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74006
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149035_1_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
Ovary epithelial cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.395491
JUN	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE221327_10_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
CA-72-JV60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216243
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3589
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.57561
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN008_HEPG2_24H:M24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12815
PAQR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32347
CARMIL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51432
nuclear part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.835926
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.493913
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5636
hsa-miR-4773	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
ZNF229	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4337
GSE202434,GSE202438_12_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CREB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58456
Aorta thoracica smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
CRCGN008_HEPG2_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14175
CRCGN011_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1187
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.582
ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.24053
KRCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63851
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.618
CRCGN016_MCF10A.TP53.M_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0516
SERF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51337
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
MYO18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34277
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47605
CRCGN017_MCF10A.WT.HP_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23127
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59567
XPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09316
Oral cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.823
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Autosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.889
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8535
PMC8040704-jcav12p2673s2.xlsx-Down-regulated_genes_in_EBF1-Unnamed_5_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
TARDBP_02_169	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.62171
MT-ND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7337
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.468
ENAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51182
hsa-miR-4694-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
UBE2NL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6385
hsa-miR-628-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Testicular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.132
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295607
GSE242333_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9098
ASNS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11926
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.72
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1447
yy2_20215434_hela_lof_human_gpl570_gds3788	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.141757
wehi164	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.856
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-371-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.342628
Internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.194
GSE186287_1_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3044
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.9122
SPIN2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18738
EEIG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42982
capan2	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
Bladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.512
DHX35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67497
KCNIP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07312
PELI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58757
Nucleoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PPC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.812
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311092
nes	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
GSE214212_2_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.377
ODR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00772
MAZ_02_199	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59406
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3087
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.104
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.38284
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0333
hsa-miR-890	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.1577
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13124
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-894-ENSG00000171116_HSFX1	Rummagene Transcription Factor Associations 2026	1.0	null
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.83518
THRAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00074
Eb	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.646
GSE216043_10_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
CRCGN015_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6593
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3828
GSE175787_8_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.609
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.7093
EB1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.76641
FBXO17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28256
GADD45B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1655
CDAN1_02_197	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60866
STAT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22646
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SRF	JASPAR Predicted Transcription Factor Targets	1.0	null
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.297
ORMDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43218
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.351
CRCGN015_MCF10A.WT.HP_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20547
col10	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.575
RIMKLA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73607
EE-98-PF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240192
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.507
GSE143662_0_v_1_dcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9834
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4943
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.335894
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
RIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1365
MYC_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFAT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82024
Uterine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
IGSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42617
RBM15_02_171	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.67231
TMEM186	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29394
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.519426
PMM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31839
ZBTB7C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.5884
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	78.978
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.909459
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
RAB3GAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88741
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9187
hsa-miR-151-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Synovium cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.413
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.243
FAM91A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63405
folic acid_homo sapiens_gpl2700_gds3656	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF333	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19761
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0415
Testis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.414
Testicular cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.0
MRPL23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18341
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3433
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7724
ZNF324	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93555
GSE221327_10_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.321165
PNKP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59046
hsa-miR-202	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GSE48812_9_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7093
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.33577
imatinib_homo sapiens_gpl96_gds3045	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
NR2F2	ENCODE Transcription Factor Targets	1.0	null
Intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
USF2_02_25	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59611
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.587
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2782
BRD3OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63027
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.983395
VPRBP_KD_GDS4829_90_human_DU145 prostate cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
TCTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85352
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239604
H1-4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71636
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.496
LRRC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67598
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23487
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.335822
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.40141
Renal Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE238018_1_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.61225
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6473
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.477
ZNF829	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42624
A-Netherlands-602-2009(H1N1)_30Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.36345
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46405
ZNF24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1125
Colorectal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.562
UM-UC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.83518
Septin collar	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.687
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8102
GSE223893_2_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16979
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.83518
NUP58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07763
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00874
IFRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.07319
Primary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.082
ZNF264	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08064
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0582
Cellular bud	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.069
RHBDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50831
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Aorta cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.589
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
UBE2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27914
GFPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70589
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.5864
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bj	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.701
u937	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
C10orf95	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34634
KE-73-XV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266596
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE186287_1_v_0_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Collagen trimer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.64
N6AMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50084
IRF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1051
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9492
Bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.572
VWDE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81369
DPYSL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85741
Embryonic carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.883
PDCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82919
OSGEP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43253
SPEGNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08787
ar_21330406_lncap_lof_human_gpl570_gds4113	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.968768
rh30	HPA Cell Line Gene Expression Profiles	-1.0	-0.826749
GSE229973_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1634
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4718
496100382_PCx_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13228
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3151
PML body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.187
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Melanoma-associated antigen 2/12	InterPro Predicted Protein Domain Annotations	1.0	null
HDAC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86667
Intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
hsa-miR-4700-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
SLC16A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09233
NCKAP5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86744
WSU-DLCL2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
NRIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07055
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.97542
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.65246
hsa-miR-4501	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
ZFP57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90916
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.0065
SPAST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85933
Mitotic septin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.868
MYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8847
GSE117212,GSE117214_0_v_1_zbtb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.436
ZNF90	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65849
Musculoskeletal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
G-401 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.681
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.983395
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	191.395
PIGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78843
Skin cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.352
skmel31	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.539
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1801
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01291
Colonic adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.772
IDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55992
ZNF99	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70835
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.237
FD-62-ZB67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211153
Ocular cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Teratocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.824
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	99.8513
B4GALNT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1503
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE221327_4_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PYGB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84002
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARHGAP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79696
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.696237
u266	HPA Cell Line Gene Expression Profiles	1.0	0.862474
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
CRCGN017_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8391
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	6.40356
ZNF692	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96087
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3384
Vascular smooth muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.582
NR2F2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Laryngeal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.884
GSE140997_2_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.97492
SPI1	ENCODE Transcription Factor Targets	1.0	null
SH2D3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25159
ERVK3-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50502
hsa-miR-4496	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GSE48812_0_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6905
CRCGN013_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1945
Spermatogonium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.491
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
UBE2N	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33787
GSE238018_1_v_5_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RDH10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35328
GSE167224,GSE168147_3_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.4821
LMNB2_02_191	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.65263
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	6.25216
PMC12583649-41419_2025_8086_MOESM11_ESM.xlsx-Sup_Table_4-Supplementary_Table_4_Mean_Influence_MI_of_regulators_in_DMSO_Capmatinib_or_Trametinib_treatment_under_HGF_stimulation_conditions_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
LRRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04695
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.9557
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7418
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.2616
k562	HPA Cell Line Gene Expression Profiles	1.0	0.832891
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.084
RABIF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07103
Bladder carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1642
Teratoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
PRPSAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4474
GSE193157_0_v_1_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF284	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96833
NEIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8532
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.961
OLFML3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4405
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1052
Cytotoxic T-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.928
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GIGYF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09578
BHLHE22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37979
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Melanoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.626
Synovial sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.413
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9119
P-19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.711
MYOZ3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3112
Bartter disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
Cleavage apparatus septin structure	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.288
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1036
Squamous Cell Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
MEL-745A cl. DS19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.572
Kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.46
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5695
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.09193
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	6.87198
COLO 800	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.72807
GSE214931_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3470785-NIHMS377161-supplement-3.pdf-458-BCL6_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
F-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.597
CCDC124	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48373
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE169205_4_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100466_PCx_probable Alzheimer's disease_no TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02252
CRCGN017_MCF10A.WT.HP_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.83585
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.615
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZGPAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37265
GSE221327_1_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
A10 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.792
ZNF582	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16346
PMC9526582__F2	PFOCR Pathway Figure Associations 2024	1.0	null
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6541
pml body	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.881714
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.395
Nuclear cap binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.756
R1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
hsa-miR-1291	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
PB-18-HD85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251612
ZHX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20489
Esophageal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.554
PPFIA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42905
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.1618
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.579
CRCGN009_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2216
Cellular bud neck septin ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.288
ETNK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84148
CREB3L4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.929
GSE206729_2_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Secondary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.571
NOBOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10526
CRCGN009_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7566
Renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.279
Peripheral Nervous System Diseases	CTD Gene-Disease Associations	1.0	2.88009
hsa-miR-9-5p	MiRTarBase microRNA Targets	1.0	null
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.97492
nuclear lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GCLM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49046
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
NHDF cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.735
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.236
Proteasome activator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.57
arsenic trioxide_homo sapiens_gpl201_gse48441	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1264 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.236
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0741
Laryngeal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.167
PHYHIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67354
TAT protein transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.042
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.20842
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.63027
ZSCAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72208
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CORO1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32936
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.447
496100350_FWM_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.23067
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.724
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.645
HTR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68669
CRCGN013_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14245
NDUFB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57415
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.83518
CEBPB	JASPAR Predicted Transcription Factor Targets	1.0	null
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.3566
MTHFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89327
DNAJC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24412
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.411
MIA PACA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.835926
Sentinel Node (Disorder)	DisGeNET Gene-Disease Associations	1.0	null
GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and neck cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.449
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6529
GSE221327_6_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:M24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24855
Eye cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.609
GSE193258,GSE193259_5_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HPAC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.835926
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.486
C4orf3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61582
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.835926
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE140997_10_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
EMC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59131
GSE143662_3_v_1_dcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8531
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ERCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67397
NKX2-4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14555
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.0622
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Seminoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.127
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Testicular cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.123
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.909459
ALDH3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73839
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.4394
PEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43654
Spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.394