association dataset threshold value standardized value GSE201657_0_v_1_ash2l_human RummaGEO Gene Perturbation Signatures -1.0 null Colon cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.376 496100391_FWM_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.11368 VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.862955 GSE197571_3_v_1_foxm1_human RummaGEO Gene Perturbation Signatures -1.0 null HIPK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77327 AA-99-PN83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.59313 NB-80-IM48_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.235382 Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Melanoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.718 CB-16-SY72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.543535 IRF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.4942 Seh1-associated complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.291 ventromedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.45724 upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02864 GB-57-XV52_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.45458 PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain stem cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.423 CRCGN015_MCF10A.WT.HP_24H:F01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.81986 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E2-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mammary gland tumor cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.408972 WC-09-GD62_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.558891 KLF10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 206.3 basal ventral medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.26714 WDR75 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22282 facial motor nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12815 CA-48-SW47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.53898 dentate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.949297 ZNF76 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99499 Uveal melanoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.024 CRCGN008_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5755 AB-64-ZX70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.874587 EBF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.2796 GPR25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34926 CB-02-XL81_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.343072 Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6VB-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-69-7979-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IB-56-JN40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.723078 CCN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52076 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4696-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE152734,GSE152735_2_v_0_pbrm1_human RummaGEO Gene Perturbation Signatures -1.0 null ERCC6L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68397 XC-61-SE50_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.214773 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8XI-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-HR-A5NC-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.292616 PMC2518525-pone.0002847.s002.xls-Dec_genes_AA-CA_p_0_01-Unnamed_1_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null OB-15-UL37_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.485334 SLC66A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33752 Central nervous system benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.099 GD-46-BU97_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.261444 Thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.732 GSE216043_11_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null rostral division of VL Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1023 KC-26-JQ92_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.669386 Colonic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.369 LD-39-FL02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.245941 QD-57-GT11_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.229866 Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.589 SP1 ENCODE Transcription Factor Targets 1.0 null recurrence GeneRIF Biological Term Annotations 1.0 null GSE186647,GSE217288_1_v_4_hnrnpc_human RummaGEO Gene Perturbation Signatures -1.0 null JA-85-SW39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.234808 GSE231720,GSE231724_3_v_0_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null GCM2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.9995 brain_a HPA Tissue Sample Gene Expression Profiles 1.0 1.2278 GSE216043_3_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null CKLF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32368 VA-48-RJ44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.38159 BF-49-QA17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.263137 QD-57-GT11_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.256354 layer II of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.86763 cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.452962 OSBPL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24545 central part of CEl Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.983851 Endocrine gland cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.812 GSE195568_2_v_10_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null BD-69-GX17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.953041 CTCF_LNCaP clone FGC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_HEPG2_48H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.77451 Sense organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Lymphatic system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.528 Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ASPSCR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92256 CRCGN014_HEPG2_24H:L05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.16449 HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.982577 AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null Meningioma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.038 CRCGN015_MCF10A.TP53.M_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.04165 SIHA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.82791 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7414-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YU-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Stomach Carcinoma DisGeNET Gene-Disease Associations 1.0 null FD-48-HZ39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.09353 AD-29-IG16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.311126 OF-05-CB18_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.34429 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A5Y1-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ovary_6a HPA Tissue Sample Gene Expression Profiles 1.0 0.96712 QA-34-PH05_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.298238 Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.685 ND-68-CU31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.253552 Integumentary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.438 parataenial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07984 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FB-39-CW59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.05749 GA-77-MH38_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.243801 Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3Z7-01A-12R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BE-81-QL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.819558 Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 496100484_FWM_no dementia_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.04421 TA-19-YA45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.416533 Brain Lower Grade Glioma_LGG_TCGA-QH-A6X8-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44606 ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.780948 HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.949311 Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JW-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-K1-A6RV-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A681-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE120612_4_v_5_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null IP6K1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79516 GC-04-UF36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.731141 CRCGN013_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.13399 endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.219047 VZ in rostral cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03647 KBTBD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60327 NCI-H650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.83756 Hepatocellular carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.79 AA-88-PJ86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.516595 GD-46-BU97_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.3582 SPIB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33099 UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.966835 HDQ-P1 COSMIC Cell Line Gene CNV Profiles -1.0 -2.93416 organelle LOCATE Curated Protein Localization Annotations 1.0 null ZNF816 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.5973 central nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.075377 central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 AB-85-JR73_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.528839 FE-10-KQ78_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.349552 SOX8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.94505 NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1106 496100507_FWM_dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.11426 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7915-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.864 RB-55-KL42_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.436888 CRCGN017_MCF10A.WT.HP_24H:P12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.084 exon GeneRIF Biological Term Annotations 1.0 null JD-81-YX02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.832318 Stomach cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.607 SNU-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0171 carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053003 GSE196117_1_v_7_clarithromycin_human RummaGEO Drug Perturbation Signatures -1.0 null Anaplastic astrocytoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.604 EB-11-MR93_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.259106 some GeneRIF Biological Term Annotations 1.0 null glioma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.375368 Esophageal Carcinoma DisGeNET Gene-Disease Associations 1.0 null UF-27-HS98_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.1035 Prostate adenocarcinoma_PRAD_TCGA-EJ-7314-01A-31R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Spinal cord TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.067 BC-54-ON71_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.728865 POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE116930,GSE116935_1_v_6_hes7_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN013_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.36416 GSE202434,GSE202438_7_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null wehi164 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.272 renal cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.181222 BD-18-MM33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.493953 GSE148200_1_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null paraventricular nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.60296 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3ET-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JB-23-ZE86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.387916 GATA4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.8837 MADD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20274 GSE176008_8_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null AD-99-SN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.602306 DA-20-VR86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.50335 skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -1.41365 FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.63557 SP2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 151.97 CRCGN012_HEPG2_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.442 SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CF-42-OS28_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.25772 AC-30-XU83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.625695 monocyte-derived dendritic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.147 Damo TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.628 CF-42-OS28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.452673 Ovarian cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.654 GSE234637_1_v_0_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null PMC9911396-41467_2023_36178_MOESM11_ESM.xlsx-Sheet1-Genes_in_10kb_vicinity_of_ZBTB12_ChIP-seq_peaks_ZBTB12 Rummagene Transcription Factor Associations 2026 1.0 null EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.74321 lower (caudal) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.64877 Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.792 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A69H-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11214527-mmc5.xlsx-TP53-gene_TP53 Rummagene Transcription Factor Associations 2026 1.0 null Pituitary GTEx Tissue Gene Expression Profiles 2023 1.0 3.61203 GSE226355,GSE226357_1_v_0_ybx1_human RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-4695-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.361556 located GeneRIF Biological Term Annotations 1.0 null NB-17-SQ59_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20075 AD-86-OB87_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.659472 Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN015_MCF10A.TP53.M_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.02245 HCC1162 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24215 Lung squamous cell carcinoma_LUSC_TCGA-58-8386-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BF-97-LS55_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.67867 lateral nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21715 Prostate adenocarcinoma_PRAD_TCGA-V1-A8WW-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-98-A53B-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AA-48-XT80_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.895568 squamous cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.523816 AB-09-EA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.234815 GSE150895,GSE150896_0_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null BC-00-YH62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.885907 Acute Myeloid Leukemia_LAML_TCGA-AB-2849-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2R9-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.32906 hsa-miR-3200-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GSE129241_3_v_0_valproic acid_human RummaGEO Drug Perturbation Signatures -1.0 null nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068414 FE-56-PV35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.37752 AC-30-XU83_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.334087 PMC3355086-pgen.1002728.s003.xlsx-Tabelle1-HEY2_upregulated_HEY2 Rummagene Transcription Factor Associations 2026 1.0 null Oral squamous cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.257 NE-94-VE83_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.491033 Internal male genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.224 provided GeneRIF Biological Term Annotations 1.0 null Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 muscle GTEx Tissue Gene Expression Profiles -1.0 -1.2311 IA-76-ZU47_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.398805 SC-17-WW78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.243083 Nephroblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.218 GSE256181_2_v_0_etv2_human RummaGEO Gene Perturbation Signatures 1.0 null MDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44617 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.447687 NR2C2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 72.2978 HSPBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8463 Lung squamous cell carcinoma_LUSC_TCGA-60-2721-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null prostate_4b HPA Tissue Sample Gene Expression Profiles 1.0 0.962442 Cervical cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.239 glioblastoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.443347 GSE120612_6_v_1_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE120612_4_v_2_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN016_MCF10A.WT.HP_24H:H17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.34843 UF-27-HS98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.22381 Female reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.66 GSE175787_4_v_7_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null HD-29-LW24_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.246223 trunk TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.074966 HCC1359 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.66426 ZNF135 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 67.5021 CRCGN015_HEPG2_48H:L20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.01107 HD-51-KD29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.345264 MYRF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28008 BE-27-XF09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.835704 medial portion of the shell Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.31278 GSE225762_1_v_0_pcmt1_human RummaGEO Gene Perturbation Signatures 1.0 null Tumor Progression DisGeNET Gene-Phenotype Associations 1.0 null CRCGN015_MCF10A.TP53.M_24H:F22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0985 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HG-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CD-13-QZ32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.321697 KP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.38224 KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01445 OV7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.891136 NKX2-4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.5378 ZNF684 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 51.1434 AF-99-HA02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.634614 ZA-63-AC60_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.247758 Neuroblastoma DisGeNET Gene-Disease Associations 1.0 null layer V of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.51249 PD-70-VS77_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.01738 ZNF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.9916 GD-66-XE49_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.216685 fastigial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.28991 DC-51-WE27_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.26984 POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nes HPA Cell Line Gene Expression Profiles 1.0 0.848711 SP1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PD-70-VS77_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.58028 GSE238018_1_v_2_mxra8_human RummaGEO Gene Perturbation Signatures -1.0 null GSE118077_7_v_2_sprr5_human RummaGEO Gene Perturbation Signatures -1.0 null BB-86-BE19_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.27773 FOSL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216043_7_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null VD-88-MW70_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.594484 bone marrow HPA Tissue Gene Expression Profiles -1.0 -0.90408 GSE234637_1_v_0_ikzf1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE119978,GSE180930_0_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null PMC12381255-41389_2025_576_MOESM3_ESM.xlsx-Differentiated_SRCAP-1879-Gene_SRCAP Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6WE-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TA-34-CK62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.981045 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.270819 CRCGN015_HEPG2_48H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.1778 High grade glioma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.901 UQCRQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78244 MYC ENCODE Transcription Factor Targets 1.0 null Telencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Lung squamous cell carcinoma_LUSC_TCGA-68-7757-01B-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null GSE238116_3_v_2_egr1_human RummaGEO Gene Perturbation Signatures -1.0 null BEL-7402 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.623 B-cell lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.009 SLC20A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23619 F2R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89496 EE-03-SG02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.812882 PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null EC-62-OE64_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.03251 AC-76-JB92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.11821 CRCGN009_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.2747 GSE238018_3_v_2_mxra8_human RummaGEO Gene Perturbation Signatures -1.0 null NCI-H2030 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.41524 Hepatitis B DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.305 OE-84-HO42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.49858 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6228-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null neuroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.131321 oral cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.744627 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-96-7544-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BE-92-TW08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.214328 ANAPC7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07755 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A57G-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WB-82-EL69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201568 UF-06-JB00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.758248 OSGEPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07692 Cyclophosphamide CTD Gene-Chemical Interactions 1.0 null hsa-miR-335-5p MiRTarBase microRNA Targets 1.0 null pallidohypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.956511 GSE242199_9_v_11_ntrk2_human RummaGEO Gene Perturbation Signatures -1.0 null FB-66-UU47_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.56721 PLAG1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 148.0 lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18883 MC-51-BT07_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.558481 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2971 hsa-miR-4457 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 MA-58-RR04_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.606372 Lung adenocarcinoma_LUAD_TCGA-86-8673-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CC-18-YW57_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.278514 hsa-miR-4435 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 Liver cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.805 liver_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.09679 panels GeneRIF Biological Term Annotations 1.0 null RNPEPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.587 CE-18-AP15_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.11477 HC-74-HM63_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.361663 Testis TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE214248_0_v_1_cxcl8_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN011_HEPG2_24H:I19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.49815 GSE223893_11_v_10_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN008_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.5587 CA-48-JF51_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.273036 Prostate adenocarcinoma_PRAD_TCGA-KK-A8II-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-64-5774-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null squamous cell carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.105695 Primary hematopoietic stem cells G-CSF-mobilized Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.847491 OC-71-BZ81_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.331319 reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 AD-51-LE62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.384832 Acn TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.905 YA-78-MS95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.77913 urinary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.056063 Peripheral nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Tumor Cell Invasion DisGeNET Gene-Phenotype Associations 1.0 null CC-68-YZ44_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.487764 Myelomonocytic leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.679 olfactory tubercle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02221 a-172 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.13988 ZNF440 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33234 KF-18-RY71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.85039 MHC class I peptide loading complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.277 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EF-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6950-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null blood GTEx Tissue Gene Expression Profiles -1.0 -1.00354 prognostic GeneRIF Biological Term Annotations 1.0 null Esophageal squamous cell carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.853 skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -0.995999 AB-71-CI37_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.31893 bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.975777 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.905635 RPL29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15908 anterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.26086 Acute Myeloid Leukemia_LAML_TCGA-AB-2817-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YD-49-HM53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.86448 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MEL-745A cl. DS19 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.375 bonemarrow_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.19472 Secondary Malignant Neoplasm Of Lung DisGeNET Gene-Disease Associations 1.0 null ME2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83721 EE-02-BO83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.45131 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8630-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NRARP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5292 GSE264621_1_v_6_secretin_human RummaGEO Drug Perturbation Signatures 1.0 null FMR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2158 Parietal lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.144 BC-40-TU13_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.718021 CRCGN015_MCF10A.WT.HP_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.09034 BZW1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67921 NE-95-RP07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203336 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.549 GSE121043_0_v_1_aldh1a1_human RummaGEO Gene Perturbation Signatures 1.0 null Oligodendroglioma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.329 Lung adenocarcinoma_LUAD_TCGA-55-6983-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EF-74-KW12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.02789 EF-01-LB20_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.354859 143B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.98097 inner CP in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.868042 Rectal Mucosa Donor 31 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.19679 nucleus accumbens, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.05428 Brain Lower Grade Glioma_LGG_TCGA-FG-A4MT-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head And Neck Carcinoma DisGeNET Gene-Disease Associations 1.0 null POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Breast Carcinoma DisGeNET Gene-Disease Associations 1.0 null S0-EE-Y7IR_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.90979 GSE216043_7_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Viral infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.521 Pigment granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.033 midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13527 oral cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.164841 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.39 Cerebral hemisphere TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Glioblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.84 BB-87-SF89_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.73024 brain cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.165741 NCI-H3122 COSMIC Cell Line Gene CNV Profiles -1.0 -2.93416 c4ii TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.5 CA-63-LW25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.34397 TPCN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99667 CRCGN017_MCF10A.WT.HP_24H:A15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.123 HT-55 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0171 Primary immunodeficiency disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.176 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43P-01A-31R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OVISE cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.995 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-BI-A0VS-01A-11R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.391931 AE-51-ZO26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.553282 CRCGN012_HEPG2_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0104 CE-96-GH46_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.18425 DC-22-OP01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.726969 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4770-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE202434,GSE202438_10_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null KA-29-AB08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.565868 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7J9-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Canarypox (Disorder) DisGeNET Gene-Disease Associations 1.0 null POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-96-HO33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.62397 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I0-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE195663_7_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null AC-84-QG99_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.244704 Breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.733 Melanocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.774 female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.301398 EA-84-SC49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.11564 Bone marrow cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.316 GSE175787_11_v_7_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null FADU COSMIC Cell Line Gene CNV Profiles -1.0 -2.93416 BD-96-HO33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.17255 FF-86-NH56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.23501 oculomotor nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.61644 wehi3b TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.95 WC-09-GD62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.49879 BC-14-CG34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.900342 astrocytoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.068485 Basal ganglion TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Bile Duct Carcinoma DisGeNET Gene-Disease Associations 1.0 null FC-85-OX77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.33705 ZFHX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53867 oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.41787 CTCF_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN010_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1583 496100409_FWM_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.39016 CRCGN009_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.66437 DPY19L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53082 OCI-LY-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.948623 CRCGN015_HEPG2_48H:M08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.01248 GA-94-MC54_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.805905 Sarcoma_SARC_TCGA-SI-AA8B-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FW-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5432-01A-02R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE202434,GSE202438_8_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null FOXO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09267 AE-42-HT01_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.204061 Acute Myeloid Leukemia_LAML_TCGA-AB-2843-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DB-56-XL71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.07923 IA-65-QX27_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.410413 CTCF_LNCaP clone FGC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Chronic Lymphocytic Leukemia DisGeNET Gene-Disease Associations 1.0 null WD-97-SF27_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.267954 hsa-miR-4731-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 MRPS25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26179 GSE135312_1_v_2_bmpr2_human RummaGEO Gene Perturbation Signatures -1.0 null LF-94-HB11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.14366 OF-05-CB18_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.22315 kidney cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.067435 Prostate adenocarcinoma_PRAD_TCGA-M7-A71Z-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WB-48-EF24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.48654 HCC1187 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.94254 astrocytoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.413912 CYTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.67639 developmental disorder of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.046733 PLK2 Kinase Library Serine Threonine Kinome Atlas 1.0 null KC-26-JQ92_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.77128 DE-73-JX23_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.00916 Lung squamous cell carcinoma_LUSC_TCGA-60-2708-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NDUFA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5554 AB-71-CI37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.411269 Temporal lobe TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ID-90-NM43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.364068 GSE149621_0_v_1_olaparib_human RummaGEO Drug Perturbation Signatures -1.0 null LARGE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92441 GSE169356_2_v_3_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-A4XC-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null paraventricular nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.27419 Biliary tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.001 IB-33-TE51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.78791 GSE216043_3_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE154936_3_v_2_remdesivir_human RummaGEO Drug Perturbation Signatures 1.0 null xp11 GeneRIF Biological Term Annotations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4078-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YD-49-HM53_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.58379 BA-46-YF32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.418333 LRRC14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23599 PICK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77277 HCC366 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27568 MCF10F Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.16584 TAT protein transport complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.913 head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.070177 dentate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.985986 Brain Lower Grade Glioma_LGG_TCGA-HT-7884-01B-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular part LOCATE Curated Protein Localization Annotations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4858-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VK-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung non-small cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.696 OVCA 429 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04944 Malignant ovarian surface epithelial-stromal neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.06 PMC12824661-BLOOD_BLD-2024-027020-mmc6.xls-Table_S14-HES4_Up_HES4 Rummagene Transcription Factor Associations 2026 1.0 null Melanocytic Nevus DisGeNET Gene-Disease Associations 1.0 null BE-27-RQ61_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.213316 ACADSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15865 JC-63-DO70_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.489055 BC-13-OQ01_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.695058 Muscle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.72766 AIM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97073 MRPL22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46812 Head and neck carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.45 AA-76-VE74_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.332333 GSE118077_7_v_8_sprr5_human RummaGEO Gene Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3PL-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN011_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2982 Acute Myeloid Leukemia_LAML_TCGA-AB-2949-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE169152_3_v_7_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.861485 DA-85-SU90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.05192 Infratentorial cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.184 QA-58-CX23_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.416971 EA-62-MI89_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.594666 TCF12_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE147876,GSE147877_2_v_11_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Ovarian clear cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.171 III, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.877217 DC-51-WE27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.624167 QA-07-KC40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.937411 DA-66-OE69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.47579 FF-86-NH56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.4371 DB-56-XL71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.672916 Uterine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.297 Male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.579 periventricular nucleus, preoptic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.46711 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7286-01A-11R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AF-72-PP21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.205751 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JD-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.95298 astroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.176995 TP53BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82255 Hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.747 PMC12358297-41388_2025_3481_MOESM3_ESM.xlsx-S9_ASCL1-regulated_genes-Unnamed_1_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null GSE238018_3_v_4_mxra8_human RummaGEO Gene Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-90-A4ED-01A-31R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nucleus LOCATE Predicted Protein Localization Annotations 1.0 null DB-56-XL71_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.63857 JD-44-KF86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.56263 VD-76-SO91_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.344447 PMC10528072-NIHMS1928302-supplement-5.xlsx-ASCL1-target_genes-ABAT_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null core of nucleus accumbens Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08313 epithelioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06048 MRPL19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11983 brain_3c HPA Tissue Sample Gene Expression Profiles 1.0 1.59483 IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.80934 CB-88-LG34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.318792 layer IIIu of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25233 NAALADL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47151 G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.861485 BD-04-NG34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.253937 PC-68-HN64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.296355 GSE160817_5_v_1_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null Sarcoma_SARC_TCGA-SI-A71Q-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Peripheral nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.194 QF-71-QI30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.523471 GSE213228_4_v_3_irak2_human RummaGEO Gene Perturbation Signatures -1.0 null JD-44-KF86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.03005 NCBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54547 Prostate adenocarcinoma_PRAD_TCGA-YL-A8SA-01A-21R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TFAP2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.477 Primary bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.164 GSE193258,GSE193259_5_v_4_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null IRF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22513 cell part LOCATE Curated Protein Localization Annotations 1.0 null SW 1463 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22758 FA-63-WI26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.797321 SG in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.906364 OC-10-FB51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.31862 Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A871-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KYSE-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0443 GB-64-HC34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.233004 VMAC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55722 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061625 PNRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19149 Neoplasm Metastasis DisGeNET Gene-Phenotype Associations 1.0 null KCNK6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5931 GSE236502_1_v_3_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.996 marker GeneRIF Biological Term Annotations 1.0 null AA-23-FM46_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.892439 BF-02-AC35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.962136 Oral squamous cell carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.882 PD-11-LM65_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.458564 NKX2-8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1528 Whole Blood GTEx Tissue Gene Expression Profiles 2023 1.0 2.29709 AF-41-QY60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.511009 GALR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85553 skeletalmuscle_c HPA Tissue Sample Gene Expression Profiles -1.0 -2.04531 KLF17 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.6354 SG in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46022 Integral component of endoplasmic reticulum membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.234 OSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87173 NKX2-5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.5514 intracellular membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null GSE216273,GSE216292_14_v_2_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null YAE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.5319 IC-18-TY61_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.756548 NE-94-VE83_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.19754 CRCGN013_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.42542 ZKSCAN1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.821 ADD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3249 DF-93-BT88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.285402 AE-04-SN76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.327691 TRMU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45181 XRCC5_02_159 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.5502 Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QH-01A-11R-A220-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lb23 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.805 Brain - Spinal cord (cervical c-1) GTEx Tissue Gene Expression Profiles 2023 1.0 0.982148 VZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00538 liver GTEx Tissue Gene Expression Profiles -1.0 -1.13578 Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 AB-97-BI36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.48541 Adult Liver Carcinoma DisGeNET Gene-Disease Associations 1.0 null brain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.076033 ENKD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10065 GSE202434,GSE202438_2_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN017_MCF10A.WT.HP_24H:E07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4451 Benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.188 LA-42-ER00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.62377 GSE216043_10_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null caco2 HPA Cell Line Gene Expression Profiles -1.0 -1.45928 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Urinary bladder cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.18 Lung adenocarcinoma_LUAD_TCGA-55-8204-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A_48H:B22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.76079 Liver cirrhosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.245 periaqueductal gray substance, ventral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.92782 GSE176008_4_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null Renal cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.951 FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.43521 PMC8481886-Table_2.xlsx-A_subsets-common_MSC_HSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DF-00-BU08_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.233105 CDKN2AIPNL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51918 ED-71-GA72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.503166 dorsal lateral geniculate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.52631 CE-69-HJ13_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.769319 CRCGN014_HEPG2_24H:J15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.77475 RARG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98139 Bladder disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.159 SHOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01083 ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01445 AA-13-DN24_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.200908 RXRA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6472-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE160817_3_v_8_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null LHX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60777 DA-40-HO94_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.631469 LA-42-ER00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.48799 Testicular cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.05 ZD-85-ND87_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.92209 CC-44-MG29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.478473 Breast disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.732 glial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.150256 external granular (germinal) layer of upper rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08757 TRMT10A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72682 DB-24-CQ08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.748579 ZB-16-BR73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.337452 FA-23-LP18_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.673403 KB-49-NF63_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.296017 ARL4D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95341 Lung squamous cell carcinoma_LUSC_TCGA-98-8021-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null excretory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.0759 CRCGN008_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6163 FC-13-VS25_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.73505 endometrium_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.17864 EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.0417 WF-96-ME07_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.658274 Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IE-01A-21R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D9-A1X3-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null organelle LOCATE Predicted Protein Localization Annotations 1.0 null lateral hypothalamic area, mammillary region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.984339 EC-62-OE64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.2341 ZNF441 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54866 HDAC7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81461 SPIC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71769 Prostate adenocarcinoma_PRAD_TCGA-YL-A8SL-01B-21R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Childhood Neuroblastoma DisGeNET Gene-Disease Associations 1.0 null PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD Rummagene Transcription Factor Associations 2026 1.0 null RBM15_02_171 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.58496 IRF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.8333 hsa-miR-4715-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 PD-70-VS77_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.54323 Stomach carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.302 AA-39-BD24_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.22671 UF-27-HS98_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.24239 Melanoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.091 GSE235550_2_v_0_hspa9_human RummaGEO Gene Perturbation Signatures -1.0 null IC-76-JU42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.375328 HD-29-LW24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.212087 DB-18-UF01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.443417 EC-62-OE64_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.962331 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZD-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null glia TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.148757 AD-16-HL96_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.267662 cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.40886 CRCGN015_MCF10A_48H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.63412 BE-49-XN43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.391434 Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A40Y-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null proliferation GeneRIF Biological Term Annotations 1.0 null DF-84-RT50_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.717 ME-31-RM40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.64335 organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063053 AE-42-HT01_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.828803 Hodgkin lymphoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.597 SLFN11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98406 VIIIA, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.2834 Lymphoid leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.2 S0-EE-Y4UM_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.330542 496100616_FWM_no dementia_TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.23647 GSE158182_3_v_0_pnpla3_human RummaGEO Gene Perturbation Signatures 1.0 null TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.26364 Male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.192 RBMX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40668 intellectual disability DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.168854 Bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.133 mouth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.076609 hsa-miR-639 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Myelomonocytic Leukemia DisGeNET Gene-Disease Associations 1.0 null hsa-miR-4698 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 CRCGN012_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.55464 AA-22-UI44_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.22014 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8061-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JC-02-ZR15_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.829695 FBXO34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85773 glioblastoma multiforme DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.162306 Lung adenocarcinoma_LUAD_TCGA-55-6979-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DD-26-VR55_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.370637 GA-47-MH68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.767329 Autoimmune disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.148 AB-85-JR73_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.218351 ZNF263 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.1926 adrenal gland HPA Tissue Protein Expression Profiles 1.0 1.34745 GSE120612_7_v_1_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null Prostate disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.574 AC-43-ZC52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.448404 SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16054 AB-80-CK34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.377114 JD-44-KF86_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.3656 NCI-H650 COSMIC Cell Line Gene CNV Profiles -1.0 -2.93416 AC-28-RT00_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.720098 PATZ1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 305.562 CRCGN015_HEPG2_48H:J16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.30323 nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 Ovarian carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.062 mammary gland cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.407832 H4C8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99858 ATP8B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61696 layer VI of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.02901 DA-66-OE69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.82902 Sarcoma_SARC_TCGA-DX-A23R-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Glioblastoma DisGeNET Gene-Disease Associations 1.0 null MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.82856 Gonadal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.665 FB-66-UU47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.32429 overall GeneRIF Biological Term Annotations 1.0 null GSE120612_7_v_5_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null Endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.664 inner SZ in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.931971 POLR2A ENCODE Transcription Factor Targets 1.0 null AB-21-VE32_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.511786 AMD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34579 GSE143782_3_v_4_calcitriol_human RummaGEO Drug Perturbation Signatures -1.0 null significance GeneRIF Biological Term Annotations 1.0 null PC-68-DU31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.454098 Melanoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.036 hsa-miR-200a TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A4XK-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AA-49-BD04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.597172 ORMDL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43218 Hematopoietic system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.593 WC-16-IR43_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.817173 JUND_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STX16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0023 mortality GeneRIF Biological Term Annotations 1.0 null BC-25-VR48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.494551 DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -13.5693 Vertebrate muscular system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE239844_6_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null BA-56-QV45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.42347 RASSF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17322 AD-11-RL84_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.241985 KA-72-WY22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.646288 HEPA 1-6 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.704 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A8O6-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZB-16-BR73_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.252617 POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE94849_1_v_4_pinometostat_human RummaGEO Drug Perturbation Signatures -1.0 null SIN3A ENCODE Transcription Factor Targets 1.0 null ID-00-IC14_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.14036 FC-20-EQ58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.43785 intermediate portion of DFC (area 9/46) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.887675 YC-45-JD42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.57989 Carcinoma Of Lung DisGeNET Gene-Disease Associations 1.0 null AD-58-PW17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.312951 BC-10-OR76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.225351 KMT2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60722 AF-00-QK19_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.383012 GD-66-XE49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.46084 Ganglion TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 DF-00-BX35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.5951 Occipital lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.063 Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78N-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SC-72-YW56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.10622 DD-75-HY40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.07842 Acute Myeloid Leukemia_LAML_TCGA-AB-2995-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.55617 AGO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.046 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YT-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 magnocellular division of VA Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.977405 Branch TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.584 Amelanotic melanoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.14 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.543 IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13864 EB1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.9319 HINT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78723 Sarcoma_SARC_TCGA-X6-A7WC-01A-12R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.824 Hypopharynx TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.674 Barr body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.778 Fluorouracil CTD Gene-Chemical Interactions 1.0 null GSE210388_2_v_0_ror2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE151412_2_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null HC-92-HE59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.91573 JD-87-KA71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.372749 status GeneRIF Biological Term Annotations 1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null Connective tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.305 CA-68-KG29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.304392 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.036 Skin melanoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.406 CCDC88C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9386 GSE174498,GSE174500_5_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null AD-16-HL96_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.05596 PAX8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54122 NA-30-HS87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.33643 Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 TAF1 ENCODE Transcription Factor Targets 1.0 null CRCGN014_HEPG2_3H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3352 Kidney Chromophobe_KICH_TCGA-KL-8336-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PLK3 Kinase Library Serine Threonine Kinome Atlas 1.0 null GSE152699,GSE152723_3_v_1_vemurafenib_human RummaGEO Drug Perturbation Signatures -1.0 null PJVK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61496 brain_3b HPA Tissue Sample Gene Expression Profiles 1.0 2.57891 PUSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40921 X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.80971 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 Respiratory system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.871 GSE236280_0_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.737 AF-99-HA02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.953813 AE-13-CX28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.328894 CB-49-OG36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.60723 Esophageal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.297 ZD-18-MI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.38518 HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0443 HD-89-HC56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.467036 posterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01624 Renal cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.577 KA-81-AG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.359154 Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Brain stem glioma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.476 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HP-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CF-42-OS28_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.643393 NCI-H1793 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1323 Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7ME-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:M15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.09182 supramammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.41042 BE-04-AN21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.264166 hel HPA Cell Line Gene Expression Profiles -1.0 -1.45928 ZFP14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 58.8161 Prostate adenocarcinoma_PRAD_TCGA-HC-A76X-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE96777,GSE96778_3_v_2_zbtb4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE240386,GSE242143_1_v_6_morc2_human RummaGEO Gene Perturbation Signatures -1.0 null Mesothelioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.59 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.949311 VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12165 Cardiac muscle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.19031 NSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19707 496100562_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.05031 Glioma DisGeNET Gene-Disease Associations 1.0 null AA-58-FJ71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.953584 Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV6-01A-21R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WC-09-GD62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.4421 pituitary GTEx Tissue Gene Expression Profiles 1.0 1.34139 hsa-miR-450b-5p TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 DA-33-BM26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.884914 Gonad TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 oral GeneRIF Biological Term Annotations 1.0 null TCF7L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05123 Parapsoriasis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.006 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZT-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRDM9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 302.023 GSE125862_2_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN013_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.0841 MA-06-DJ95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.6759 Lung adenocarcinoma_LUAD_TCGA-91-6836-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CYCS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50858 non-Hodgkin lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.182 POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner SZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2093 hsa-miR-891b TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A4IJ-01A-31R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GNA13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69803 Prostate cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.573 NR1D2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.7288 relevance GeneRIF Biological Term Annotations 1.0 null WDFY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65677 IZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.978008 TENM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30462 upper (rostral) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.45228 astroglia TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.176049 BC-01-JL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.520845 astrocytoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.368624 CRCGN008_HEPG2_24H:L04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.286 AC-47-YZ27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.864563 PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53 Rummagene Transcription Factor Associations 2026 1.0 null EF-85-DA07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.400408 Cutaneous Melanoma DisGeNET Gene-Disease Associations 1.0 null CB-92-VC05_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.334803 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.33 Rectum adenocarcinoma_READ_TCGA-F5-6702-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7VF-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE102505_1_v_3_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.46529 YA-78-MS95_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.23982 FAM47E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44114 survival GeneRIF Biological Term Annotations 1.0 null cellular_component LOCATE Curated Protein Localization Annotations 1.0 null CHUK_knockdown_108_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.50058 Epithelioid cell melanoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.044 Small Cell Carcinoma Of Lung DisGeNET Gene-Disease Associations 1.0 null ELF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.3452 Lung adenocarcinoma_LUAD_TCGA-MP-A4T6-01A-32R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 ZNF235 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43123 GSE226355,GSE226357_1_v_4_ybx1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE151612_0_v_8_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Sarcoma_SARC_TCGA-RN-A68Q-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-8359-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HT-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN008_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1587 PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-334-CEBPB_CEBPB Rummagene Transcription Factor Associations 2026 1.0 null NE-20-WM78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.858871 Peripheral nervous system neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.328 AC-28-RT00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.809626 pyrophosphate-dependent phosphofructokinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.568 OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.992496 HCC1419 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.653421 ZNF536 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21859 JE-22-JR20_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.33057 AE-95-UU45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.394803 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EC-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058994 Stolon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.623 head and neck squamous cell carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.59405 FC-35-BX82_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.305986 SLC2A10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97691 Lung adenocarcinoma_LUAD_TCGA-55-8506-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE102505_6_v_3_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null PD-94-WO47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.535053 Testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.449 ZNF461 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42581 B-lymphocyte cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.256 JE-72-KV75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.959543 PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null UBC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31806 RA-42-CM42_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.522499 AIMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2995 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08421 SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.61925 anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.52504 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A410-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CC-50-FK24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.366974 MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.865012 SUB1_02_161 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.23704 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20V-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7831-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-75-5147-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and neck squamous cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.422 GSE210870_0_v_2_snai1_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF644 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46021 VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07667 GAS2L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91852 NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00174 RA-42-CM42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.368437 Disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.584 Lung adenocarcinoma_LUAD_TCGA-50-6591-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM10248_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Spinal cord disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.044 LD-14-PB06_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.228347 TCF12 ENCODE Transcription Factor Targets 1.0 null Reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.813 AA-22-UI44_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.0183 MAP7D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88292 Primary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.987 malignant glioma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.538893 AA-52-JS03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.447918 496100380_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.9569 AD-58-PW17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.552308 KA-75-LP02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.08072 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PDCD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36035 AE-56-SL06_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.12523 RPS6KB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62361 C1orf174 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60358 UBE2D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6906 12734205-TableS2 GeneSigDB Published Gene Signatures 1.0 null Heart - Left Ventricle GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.771108 SE-15-AV21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.482507 PA-75-VL17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.45208 GSE264621_1_v_3_secretin_human RummaGEO Drug Perturbation Signatures 1.0 null Avian pallium TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1IA-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OS-01A-12R-A220-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE160817_3_v_1_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null GA-87-BR97_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.56141 Transcription factor TFIIIC complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.514 KB-49-NF63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.21731 Lymphatic system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.528 AD-58-PW17_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.750716 CRCGN008_HEPG2_24H:H01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.85175 AD-53-VC77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.319225 GSE234637_2_v_0_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null HB-06-WU12_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.37042 fastigial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.50606 THEM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88385 CB-16-SY72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.71167 Liver And Intrahepatic Biliary Tract Carcinoma DisGeNET Gene-Disease Associations 1.0 null Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.771 JA-85-SW39_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.254886 KLF14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 131.853 LSM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.635 nucleus accumbens, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.84464 Integumentary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.487 GSE175787_8_v_2_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null ACADVL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13444 CRCGN010_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.31703 MSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74546 DA-27-BW20_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.40405 ME-31-RM40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.26494 496100360_FWM_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.08226 Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6789-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE240386,GSE242143_8_v_6_morc2_human RummaGEO Gene Perturbation Signatures -1.0 null PMC12178937-mmc6.xlsx-L_MAFF_KDvsL_C_deg_all-gene_id_MAFF Rummagene Transcription Factor Associations 2026 1.0 null BD-38-QC39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.41747 CRCGN010_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.01821 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 VSX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25278 ZNF513 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59128 HD-62-KE69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.395108 Sperm annulus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.655 POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216043_10_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE120612_6_v_0_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null CREB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58456 PNMA6F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66796 VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20342 NSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01726 macroglia TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.166045 a24 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.21 Lung adenocarcinoma_LUAD_TCGA-MN-A4N5-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RXRG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.9531 Bone marrow disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.311 ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.30654 PMC7445411-CPR-53-e12862-s006.xlsx-Sheet1-Supplementary_Table_S4_Gene_expression_profiling_of_NT-MSC_and_III-MSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null WIPI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67623 ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.07257 MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.49532 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E6-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210870_0_v_1_snai1_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN008_HEPG2_24H:G24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.54805 Myeloid leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.388 epithelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05242 QE-79-XO29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.389028 LRRC8E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01453 RD-90-OY66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.54395 CRCGN008_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0587 KA-75-LP02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.89698 NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.25032 globose nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.986305 ZNF281 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 274.82 layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.52422 SLU7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10788 Brain Lower Grade Glioma_LGG_TCGA-VM-A8CD-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Retrotransposon nucleocapsid COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.222 Limbic system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ZNF221 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38987 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PD-70-VS77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.96828 SLC8B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71178 HD-51-KD29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.53551 FE-10-KQ78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.38971 KC-26-JQ92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.548473 arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.83002 mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060748 Thoracic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.731 POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GC-04-UF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.03878 MAD2L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.4586 IKZF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.23779 anterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.41703 S0-EE-YEKU_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.54887 brain GTEx Tissue Gene Expression Profiles 1.0 1.37562 LGALS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90024 bonemarrow_5a HPA Tissue Sample Gene Expression Profiles -1.0 -0.933228 BA-84-WN26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.219769 CRCGN015_HEPG2_48H:I06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4142 Lung squamous cell carcinoma_LUSC_TCGA-33-4533-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TNFSF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81752 Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CTCF ENCODE Transcription Factor Targets 1.0 null PRKAR1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3285 Lung adenocarcinoma_LUAD_TCGA-97-7547-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.834543 hypoglossal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.862461 Colorectal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.667 FA-80-DR66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.203 GSE226408_1_v_0_inpp4b_human RummaGEO Gene Perturbation Signatures -1.0 null CC-09-YG11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.440722 Lung adenocarcinoma_LUAD_TCGA-86-7953-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4 Rummagene Transcription Factor Associations 2026 1.0 null tuberomammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.60559 NCI-H1373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00045 CB-16-SY72_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.36675 P-19 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.656 outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.912529 RASL11A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86942 VIIIA Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.960488 embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065748 mpp89 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.077 POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null oral squamous cell carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.783557 AF-25-BS76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.240687 AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -5.72581 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6960-01A-41R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EF-80-OD07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.638133 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null liver HPA Tissue Gene Expression Profiles -1.0 -1.27478 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YM-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3022 496100317_FWM_no dementia_no TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.17439 AB-71-CI37_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.403148 ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null Mouth disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.107 Eye TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 LCMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99876 Lung squamous cell carcinoma_LUSC_TCGA-43-7658-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ethmoid bone TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.527 Acute Myeloid Leukemia_LAML_TCGA-AB-2934-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOSL2 ENCODE Transcription Factor Targets 1.0 null PK-59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1106 CRCGN011_HEPG2_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.10365 SUM52PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.722039 Nongerminomatous Germ Cell Tumor DisGeNET Gene-Disease Associations 1.0 null GSE223893_2_v_9_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null AC-33-YJ09_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.229122 Uterine Carcinosarcoma_UCS_TCGA-N9-A4PZ-01A-22R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AF-00-QK19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.49226 CRCGN014_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.70845 CETN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77732 PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null GSE196117_1_v_0_clarithromycin_human RummaGEO Drug Perturbation Signatures -1.0 null EA-18-FP00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.60355 SERP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82434 Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3ZE-01A-11R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Solid Neoplasm DisGeNET Gene-Phenotype Associations 1.0 null CRCGN016_MCF10A.TP53.M_24H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.03134 METTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75791 SEPTIN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22873 brain cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.387781 TA-34-CK62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.822029 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A66X-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KB-78-BE93_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.374056 GSX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5368 IKKB Kinase Library Serine Threonine Kinome Atlas 1.0 null X Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.48082 Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.328 Stomach GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.551951 AA-30-BE85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.558543 Cerebral lobe TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Corpus callosum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.121 B16-F1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.553 FD-29-MM50_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.277272 Prostate adenocarcinoma_PRAD_TCGA-CH-5794-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BD-18-MM33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.921018 GSE193258,GSE193259_9_v_0_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null Leukemia DisGeNET Gene-Disease Associations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5526-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BE-92-TW08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.902659 AD-30-VB23_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.353052 HEY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.517 IA-76-ZU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.461509 600MPE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.921224 Melanosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.057 Car cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.502 Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Musculoskeletal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.439 adenocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065911 ZBTB14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.7337 independent GeneRIF Biological Term Annotations 1.0 null TCF20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.05139 GGCT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32591 CRCGN015_HEPG2_48H:G06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.83121 lateral hypothalamic area, tuberal region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.942248 EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.46572 Childhood Glioblastoma DisGeNET Gene-Disease Associations 1.0 null BB-77-QQ71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.47392 driver GeneRIF Biological Term Annotations 1.0 null Head and neck cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.549 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.240826 GSE199204,GSE211619_4_v_6_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null motor nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05787 CC-04-FJ21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.96734 GA-77-MH38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.24749 XD-08-ZW85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.555812 Acute leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.033 KA-81-AG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.18562 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.1071 TIMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21922 GSE102132_2_v_1_irf3_human RummaGEO Gene Perturbation Signatures 1.0 null PMC9013128-NIHMS1795992-supplement-4.xlsx-SKmel147_ARID2_KO_Downregulated-Gene_name_ARID2 Rummagene Transcription Factor Associations 2026 1.0 null Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.085 Germ Cell Tumor DisGeNET Gene-Disease Associations 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8311-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BC-54-ON71_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.576899 FC-20-EQ58_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.767998 GSE151412_2_v_3_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null Multiple Myeloma DisGeNET Gene-Disease Associations 1.0 null Temporal lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.359 BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.07475 IL18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21692 POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-7670-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NTPCR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12607 breast adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.099593 DA-35-DU85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.277577 CTCF_02_185 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.0 IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.01947 GA-47-MH68_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.288758 DA-20-VR86_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.02349 COV362 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16671 SP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 230.082 DC-51-WE27_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.20696 CRCGN014_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.15879 PRKAR2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20408 B16-F10 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.264 poor GeneRIF Biological Term Annotations 1.0 null Synovial sarcoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.631 Bile duct cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.047 Breast - Mammary Tissue GTEx Tissue Gene Expression Profiles 2023 1.0 4.05035 iPS-18 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.1574 hsa-miR-3197 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 HD-29-PZ41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.750182 ATAD2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51082 ESCO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5642 Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WV-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KB-78-BE93_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.286412 CB-87-RB49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.249338 QE-79-XO29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.384505 AA-23-FM46_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.04501 FB-33-LI31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.294638 CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -5.63343 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19E-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null T47D Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.16864 POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A4QR-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-91-6835-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4TF-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DC-93-NP78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.800723 Sarcoma_SARC_TCGA-DX-A6B8-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE152699,GSE152723_0_v_2_vemurafenib_human RummaGEO Drug Perturbation Signatures 1.0 null EE-03-SG02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.85462 CRCGN011_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0553 ISG20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61431 GSE216043_10_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null KLF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 161.224 MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5QA-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DCBLD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02665 ZNF548 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24361 Childhood Leukemia DisGeNET Gene-Disease Associations 1.0 null GSE80098,GSE80366_0_v_8_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null BL698 (DIDO1) NURSA Protein Complexes 1.0 null GSE129241_4_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5879-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE175787_5_v_9_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5KV-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in subcallosal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.45192 MA-58-RR04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.353698 glioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.226411 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MT-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HB-87-YY34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.231624 Cholangiocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.814 MAP4K4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58107 GSE216043_11_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null SC-25-HE80_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.325557 brain HPA Tissue Gene Expression Profiles 1.0 1.71862 JC-06-ED36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -7.15178 KLF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 149.201 TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA3 JASPAR Predicted Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-93-8067-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE143782_3_v_11_calcitriol_human RummaGEO Drug Perturbation Signatures -1.0 null SG in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.1838 radiation GeneRIF Biological Term Annotations 1.0 null Cell type benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.193 AA-22-UI44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.06024 choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.88249 AA-79-SX47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.284488 JUND ENCODE Transcription Factor Targets 1.0 null NCI-H2073 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.21531 GSE236502_2_v_3_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null Liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.73 RA-27-ST16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.882494 Lung squamous cell carcinoma_LUSC_TCGA-63-5131-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TNKS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53593 NHEK Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.0152 Kidney Chromophobe_KICH_TCGA-KN-8427-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BD-49-MD69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.02769 CRCGN015_HEPG2_48H:G04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.87115 NAA10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.14553 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.948623 YA-85-VH07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.262385 DOR 13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.891136 GSE203017_0_v_1_irs2_human RummaGEO Gene Perturbation Signatures -1.0 null Muscular system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 CA-75-HA22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.263216 VD-88-MW70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.21154 Synovium cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.584 predictive GeneRIF Biological Term Annotations 1.0 null GSE169356_0_v_5_ivermectin_human RummaGEO Drug Perturbation Signatures 1.0 null GD-46-BU97_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.743186 IC-28-HS37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.811 CA-68-TC79_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.314749 FF-86-NH56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.87073 Lung squamous cell carcinoma_LUSC_TCGA-63-A5MW-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GA-59-RW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.86594 PMC12634441-41375_2025_2771_MOESM7_ESM.xlsx-RNAseq-Table_S2_Bulk_RNA-seq_GATA2_vs_control_Only_p-adj_0_05_GATA2 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN009_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.45744 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YD-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIPR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18466 GSE160817_5_v_6_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null GSE172016_2_v_1_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null hs431 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.947 smoothmuscle_8b HPA Tissue Sample Gene Expression Profiles 1.0 0.855914 DA-28-TM43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.372345 GSE102870_3_v_0_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null Integral component of organelle membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.148 GB-57-XV52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.543694 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6868-01B-12R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.39761 JE-04-LS32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.610661 GSE102505_5_v_0_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null BE-28-WW67_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.986646 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6873-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EJ-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MXRA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72865 astrocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.177933 Sarcoma_SARC_TCGA-IW-A3M5-01A-22R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE147876,GSE147877_2_v_10_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Esophageal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.283 lateral hypothalamic area, anterior region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.999009 DMS 273 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.966835 HCC89 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22935 GSE202434,GSE202438_12_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null BD-04-NG34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.35345 KC-48-OO62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.4797 GSE237053_1_v_0_comt_human RummaGEO Gene Perturbation Signatures 1.0 null placenta HPA Tissue Protein Expression Profiles 1.0 0.723802 PITPNC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.887 MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09915 KA-29-AB08_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.0388 DGKE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3781 skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -1.51451 GSE158458_2_v_3_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A8XE-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Htk TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.663 GF-35-IT27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.16766 Cytotoxic T-lymphocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.467 correlate GeneRIF Biological Term Annotations 1.0 null maged4 GeneRIF Biological Term Annotations 1.0 null Leukopenia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.012 AE-85-KE62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.800455 AE-39-DG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.58897 VIIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.27977 KE-37-MN32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.02738 BB-87-SF89_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.403806 PANC 05.04 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.936197 Renal carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.594 GSE159049_3_v_0_sox2_human RummaGEO Gene Perturbation Signatures -1.0 null Male reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.249 breast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.352969 CRCGN008_HEPG2_24H:O08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.22545 GSE143499_0_v_1_gata6_human RummaGEO Gene Perturbation Signatures -1.0 null PMC9714459-DataSheet3.xlsx-Supplement_3A-1166_common_elements_in_MSC_and_Fibroblasts_MSC Rummagene Transcription Factor Associations 2026 1.0 null Non-Small Cell Lung Carcinoma DisGeNET Gene-Disease Associations 1.0 null CRCGN011_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1434 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZJ-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null u-87mg cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.636785 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null HA-17-MS45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.425054 CRCGN008_HEPG2_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.055 Skin - Sun Exposed (Lower leg) GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.771108 FC-20-EQ58_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.21818 Seminoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.082 S0-EE-X7LX_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.233289 t47d HPA Cell Line Gene Expression Profiles -1.0 -1.45928 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null Biliary tract cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.076 DC-17-ZB19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.3404 U2AF2_02_170 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 4.08746 LF-94-HB11_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.322861 QB-42-MC63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.289499 Skin Cutaneous Melanoma_SKCM_TCGA-W3-A825-06A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-141 TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 TE-15-RO34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.467208 EBV-B cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.592 thorax TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.106808 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HI-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GD-39-YG36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.206951 Brain Lower Grade Glioma_LGG_TCGA-QH-A6X4-01A-51R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hs-578t cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.934054 CD-05-PU90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.762818 I-II Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.61575 PHACTR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21803 GSE226408_2_v_3_inpp4b_human RummaGEO Gene Perturbation Signatures 1.0 null SPIB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.1968 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7374-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4801 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 BA-39-HG26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.346774 CRCGN015_HEPG2_48H:F16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.56645 mda-mb-231 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.280717 oral mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.439123 early GeneRIF Biological Term Annotations 1.0 null WC-16-IR43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.03513 LC-12-VN85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.572364 Brain_Germinal_Matrix Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.975254 FC-15-XG61_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.214562 AB-30-CR11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.421961 squamous cell carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.45567 breast cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.36526 COR-L311 COSMIC Cell Line Gene CNV Profiles -1.0 -2.93416 YD-49-HM53_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.68988 Lung squamous cell carcinoma_LUSC_TCGA-85-8352-01A-31R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BE-79-QU25_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.957078 Bile duct adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.06 CRCGN013_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.51525 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ED-05-LQ40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.23449 Liver Carcinoma DisGeNET Gene-Disease Associations 1.0 null GSE132369,GSE132371_1_v_0_cccp_human RummaGEO Drug Perturbation Signatures -1.0 null Bile duct carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.058 Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.772 CRCGN008_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.84135 Lung squamous cell carcinoma_LUSC_TCGA-52-7810-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.235748 USP21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30845 GSE186647,GSE217288_1_v_7_hnrnpc_human RummaGEO Gene Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4SY-01A-21R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CC-61-HH09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.2532 TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-VP-A876-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LA-42-ER00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.26439 Breast_vHMEC Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.25608 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J5-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-3_E2F2-Gene_E2F2 Rummagene Transcription Factor Associations 2026 1.0 null Sarcoma_SARC_TCGA-JV-A5VF-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RARA::RXRG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.1254 GA-88-CF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.68111 Skin cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.095 ZNF530 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 115.527 SYNDIG1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61782 Lung adenocarcinoma_LUAD_TCGA-64-5775-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DB-54-GQ68_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.06327 anterior amygdaloid area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10931 Intraocular melanoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.019 GSE216043_11_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null BC-10-SB73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.46982 Lung adenocarcinoma_LUAD_TCGA-MN-A4N1-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.82921 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I7-06A-22R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JD-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FB-66-UU47_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.657054 TBX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1418 RB-55-KL42_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.224699 Melanoma DisGeNET Gene-Disease Associations 1.0 null Embryonic germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.563 Diphtheria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.05 Lung adenocarcinoma_LUAD_TCGA-86-8073-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060188 Pancreas disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.226 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29M-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-2_E2F1-Gene_E2F1 Rummagene Transcription Factor Associations 2026 1.0 null AC-35-CK01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.12971 CRCGN015_HEPG2_48H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.08995 GSE238018_1_v_4_mxra8_human RummaGEO Gene Perturbation Signatures -1.0 null BC-13-OQ01_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.43835 Acute Myeloid Leukemia_LAML_TCGA-AB-2887-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GB-46-CK08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.281282 GSE216043_7_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF827 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75965 CA-75-HA22_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.19149 trochlear nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.11219 lateral hypothalamic area, anterior part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.982196 Oropharynx (Excludes Nasopharynx) DisGeNET Gene-Disease Associations 1.0 null GSE175787_8_v_7_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GSE96777,GSE96778_1_v_0_zbtb4_human RummaGEO Gene Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-A491-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.407 SGF29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3686 brain cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.245491 APLNR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06341 SIN3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HPF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69645 DE-48-HZ49_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.204861 Sensory system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.017 Male reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.599 Acute Myeloid Leukemia_LAML_TCGA-AB-2942-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE119978,GSE180930_6_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE213228_1_v_5_irak2_human RummaGEO Gene Perturbation Signatures 1.0 null Cervix disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.236 BT549 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.00374 BF-54-GX35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.309977 GSE216043_10_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Uveal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.022 MHC class II protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.796 Rectal Carcinoma DisGeNET Gene-Disease Associations 1.0 null GSE120612_4_v_1_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041398 Prostate adenocarcinoma_PRAD_TCGA-HC-7819-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE175787_8_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null FD-62-ZB67_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.215991 LOU-NH91 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12023 EE-03-SG02_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.336801 GSE102870_11_v_0_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE216043_3_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null liver_c HPA Tissue Sample Gene Expression Profiles -1.0 -1.53278 Prostate adenocarcinoma_PRAD_TCGA-VN-A88L-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FB-32-PY27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.220965 skeletal muscle HPA Tissue Protein Expression Profiles 1.0 0.723802 AB-97-BI36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.438261 skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.12932 JC-06-ED36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.94027 endometrium_4a HPA Tissue Sample Gene Expression Profiles 1.0 1.17436 POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RIOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14777 FF-06-MO73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.36642 Rectum adenocarcinoma_READ_TCGA-EI-6509-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF563 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82976 RXRA ENCODE Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SE-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cholangiocarcinoma DisGeNET Gene-Disease Associations 1.0 null HC-74-FM38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.314251 AA-23-FM46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.35138 CRCGN015_HEPG2_48H:I07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.58943 Lung adenocarcinoma_LUAD_TCGA-91-8499-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WE-48-PP43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.21485 MFGE8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50723 Carcinogenesis DisGeNET Gene-Phenotype Associations 1.0 null GSE202825_2_v_1_ano1_human RummaGEO Gene Perturbation Signatures -1.0 null overexpression GeneRIF Biological Term Annotations 1.0 null GSE218060_5_v_6_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN013_HEPG2_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.25548 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.05099 GA-59-RW04_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.240794 III Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.97315 EB-67-WB79_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.734702 GM12878 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.861869 FD-59-TC81_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.209099 FD-72-CE19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.241786 ZGRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70889 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.599 head and face region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25968 GSE202434,GSE202438_6_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE102505_5_v_3_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null DB-21-FY75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.13191 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 FF-28-ES17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.379815 relapsefree GeneRIF Biological Term Annotations 1.0 null FD-55-XG26_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.296034 Kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.553 dorsomedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.20148 GSE154350_1_v_0_ascl2_human RummaGEO Gene Perturbation Signatures -1.0 null lateral subdivision of BNST Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.34922 IE-38-FB31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.303049 inner SZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.854494 GSE68925_1_v_0_fasudil_human RummaGEO Drug Perturbation Signatures -1.0 null SC5D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44441 lateral tuberal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.08136 roles GeneRIF Biological Term Annotations 1.0 null embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.072595 Lung squamous cell carcinoma_LUSC_TCGA-NK-A5D1-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2BC7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61778 olfactory tubercle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.945475 indusium griseum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.934214 KMT5C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78098 GSE210682_2_v_3_methadone_human RummaGEO Drug Perturbation Signatures 1.0 null HA-32-YH61_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.283461 term GeneRIF Biological Term Annotations 1.0 null ZNF701 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 74.341 alternatively GeneRIF Biological Term Annotations 1.0 null lateral portion of the shell Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.994289 three GeneRIF Biological Term Annotations 1.0 null CRCGN013_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.16361 reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.251934 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.177 AE-39-DG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.927498 FA-36-VA24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.77139 GSE216043_3_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null CB-99-OG76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.387042 CRCGN011_HEPG2_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3995 RDH11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67712 Forebrain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Sarcoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.414 Hematologic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.758 GA-88-CF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.30968 SH3BGRL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54596 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JA-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210682_0_v_3_methadone_human RummaGEO Drug Perturbation Signatures 1.0 null Acute lymphoblastic leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.023 BE-73-KD75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.763407 S0-EE-WJKI_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.99744 FA-63-WI26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.85165 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6221-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CE-96-GH46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.58448 SA-03-IQ14_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.33998 BE-79-QU25_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.588632 PD-26-DC63_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.348497 JA-26-YQ32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.214801 PPARD JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.1641 CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-570 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 DD-89-HG56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.303786 hepatocellular GeneRIF Biological Term Annotations 1.0 null GC-04-UF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.37294 Oropharynx TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.831 KM-3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.741 lateral mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.7532 Connective tissue cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.436 Brain Lower Grade Glioma_LGG_TCGA-TM-A84B-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE151612_4_v_8_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Synovial sarcoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.584 AC-83-LN99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.225465 RXRA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5741-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE214931_4_v_5_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null MDAMB436 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.758892 SW 780 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.93693 TK-6 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.983 WC-16-IR43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.2896 DA-27-BW40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.310339 MYC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DTX3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84199 CRCGN009_HEPG2_24H:L07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9125 LE-40-JW92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.117 AB-33-EM56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.24879 BA-69-TQ80_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.618572 BC-54-ON71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.25595 FOXD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40629 VA-92-QP54_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.411977 Squamous Cell Carcinoma Of Esophagus DisGeNET Gene-Disease Associations 1.0 null MZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.98199 Ependymoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.775 supraoptic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.982215 Skin disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.445 UM-UC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3022 GSE238018_3_v_0_mxra8_human RummaGEO Gene Perturbation Signatures -1.0 null outer SZ in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.922068 GSE178907_4_v_3_fkrp_human RummaGEO Gene Perturbation Signatures 1.0 null Central Neuroblastoma DisGeNET Gene-Disease Associations 1.0 null AB-80-CK34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.72334 BC-13-OQ01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.623897 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058001 Esophageal carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.093 SLC35E3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3758 AD-16-HL96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.27108 CF-87-AS90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.02978 C4orf36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65416 exons GeneRIF Biological Term Annotations 1.0 null GD-79-TW34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.68189 FA-63-WI26_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.249884 Sarcoma_SARC_TCGA-QQ-A5VB-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null astroglial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.176995 HCN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63789 PYGB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84002 AB-30-CR11_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.305771 endometrium HPA Tissue Gene Expression Profiles 1.0 0.885555 GSE143782_6_v_8_calcitriol_human RummaGEO Drug Perturbation Signatures 1.0 null Intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.669 ZNF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54858 trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.61045 FE-10-KQ78_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.27485 Tetanus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.508 MFM-223 COSMIC Cell Line Gene CNV Profiles 1.0 2.15687 APOBEC3D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37142 EC-98-KI28_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.402769 VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.26573 FAM110D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96818 NF-21-HQ00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.7432 did GeneRIF Biological Term Annotations 1.0 null CB-02-XL81_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.668761 breast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.121384 pontobulbar body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.64089 AC-84-QG99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.00456 ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.891136 adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055633 preoptic region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.84176 GB-73-QS80_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.556788 pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.951214 B-lymphoblastoid cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.958 PAOX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16438 glial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.360782 emboliform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.913443 S0-EE-YEKU_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.37704 496100554_FWM_no dementia_no TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.17643 Peripheral blood mononuclear cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.771 TAF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ND-39-PO34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.05232 Rectum adenocarcinoma_READ_TCGA-EI-6885-01A-11R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN009_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.26895 EHF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92793 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A24D-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cholangiocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.06 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A85H-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cystadenocarcinoma DisGeNET Gene-Disease Associations 1.0 null GSE216043_7_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null NA-29-UI75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20038 Gbm cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.005 BA-84-WN26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.306941 RD-92-QT24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.317954 KB-46-EJ60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.778552 INSM1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.2917 Neurotoxicity Syndromes CTD Gene-Disease Associations 1.0 1.1122 GSE213228_4_v_0_irak2_human RummaGEO Gene Perturbation Signatures -1.0 null Uterine disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.272 FD-91-OK66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.459749 GF-37-MB64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.511028 DA-58-LZ09_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.708557 Fetal_Brain_Female Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.05923 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q1-06A-21R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAP3K4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49255 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null Nervous system benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.154 FADD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80302 Leukocyte disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.38 DC-70-EK34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.503855 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q5-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mammary gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.15592 BD-73-TX58_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.04741 B800-850 antenna complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.687 MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.845659 HEY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75274 HC-74-HM63_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.385611 CRCGN014_HEPG2_24H:M23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.07499 CRCGN011_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.44685 RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1106 ALX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43293 PELI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58757 Acute myeloid leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.295 KRIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06462 GSE175787_5_v_2_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null KE-73-XV62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.79933 Ovarian disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.623 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DG-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CF-65-GU65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.73948 cortico-medial group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.903906 MD-86-UW46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.39095 SB-28-EJ14_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.439809 SUPT16H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76573 midbrain raphe nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.854117 AB-33-EM56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.220145 H3K4me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE223893_2_v_10_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null NF-21-HQ00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.678072 Primary Malignant Neoplasm Of Lung DisGeNET Gene-Disease Associations 1.0 null NB-80-IM48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.37202 ZNF469 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9927 ATP1B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57919 AA-11-RO46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.59468 496100418_TCx_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.18318 UCP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10632 Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A767-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN009_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.55105 PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01259 Cerebral cortex TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 REST JASPAR Predicted Human Transcription Factor Targets 2025 1.0 64.538 BB-23-PM31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.241049 EE-03-SG02_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.42471 496100346_FWM_no dementia_TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.66713 AD-86-OB87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.497163 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HU-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.377 Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EL-01A-12R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A-2058 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.519 arcuate nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.87844 Nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.92 Prostate adenocarcinoma_PRAD_TCGA-H9-A6BY-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC3712200-584604.f1.pdf-43-THYN1_THYN1 Rummagene Transcription Factor Associations 2026 1.0 null AB-33-EM56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.556804 specific developmental disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.048008 YF-00-IN39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.500175 Neuroblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.31 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A71A-01A-22R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RB-55-KL42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.268576 CC-68-YZ44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.02274 AC-84-QG99_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.63645 MAMSTR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90632 A-CA-04-2009(H1N1)_18Hour_None_GSE37571 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.54657 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01445 RB-55-KL42_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208047 DF-00-BU08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.24639 Oral cavity cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.268 YA-92-YO01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.09512 EA-39-YN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.56464 WC-09-GD62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.531715 GC-04-UF36_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.45379 OV56 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.845659 WM-278 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.703 EFCAB14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.27801 POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LOX-IMVI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.949311 YF-77-FV50_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.205409 RAD50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16394 intracellular organelle LOCATE Curated Protein Localization Annotations 1.0 null GSE154577_7_v_10_plagl1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE213228_2_v_0_irak2_human RummaGEO Gene Perturbation Signatures 1.0 null HB-06-WU12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.19597 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A5UC-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BC-54-ON71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.66786 Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01529 Lung squamous cell carcinoma_LUSC_TCGA-63-A5MV-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null heart muscle HPA Tissue Protein Expression Profiles 1.0 1.34745 PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3 Rummagene Transcription Factor Associations 2026 1.0 null LUC7L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92546 HUP-T4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17695 perifornical nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01781 Vitiligo DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.131 AA-18-GQ83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.216648 Lung squamous cell carcinoma_LUSC_TCGA-85-7843-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SAP30BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33334 Skin Cutaneous Melanoma_SKCM_TCGA-D9-A148-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CBX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02394 HNF4A JASPAR Predicted Transcription Factor Targets 1.0 null Influenza DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.17 FAM210B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97157 CRCGN015_HEPG2_48H:P13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.25454 CD-35-BD44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.92086 PRKCSH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78487 KAT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04612 EB-44-GM58_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.307427 SP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 214.633 Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.192 Lung adenocarcinoma_LUAD_TCGA-69-A59K-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 FU97 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22758 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HQ-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.945753 Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FO-01A-21R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A895-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null QA-34-PH05_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.218297 CC-44-MG29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.372655 Peripheral blood lymphocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.447 GRAMD1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.73452 glioblastoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.399871 Liver carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.787 AB-30-CR11_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.701131 POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hodgkin's lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.196 VZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03008 AC-75-LR63_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.694975 VIIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13782 TB-06-VB30_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.288072 Breast carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.09 CB-02-XL81_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.223843 BT474 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.15355 SLC1A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3349 relation GeneRIF Biological Term Annotations 1.0 null CRCGN011_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1371 PMC4467436-oncotarget-06-6267-s002.xlsx-140527_cd44Cutoff_txt-SOX2-M_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null preoptic region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.26587 Rectum adenocarcinoma_READ_TCGA-DC-6156-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7754-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FF-86-NH56_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.558468 MS751 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.98141 Lung GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.771108 ERO1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35691 medial vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20859 GSE186440,GSE186443_2_v_5_daxx_human RummaGEO Gene Perturbation Signatures -1.0 null DD-42-PC65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.243906 CRCGN011_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.043 BC-61-ZY95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.507066 DF-00-DK69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.3026 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3466-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null M/G1 phase-specific MADS box-forkhead transcription factor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.632 dorsal lateral geniculate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.958913 MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.948623 FAM20C Kinase Library Serine Threonine Kinome Atlas 1.0 null GSE175787_5_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null JD-87-KA71_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.882687 CCDC102A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49627 High endothelial venule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.624 MRPL40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19884 Sarcoma_SARC_TCGA-DX-AB2P-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adipose - Subcutaneous GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.771108 Central nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.875 PMC12824706-BLOOD_BLD-2025-028441-mmc3.xlsx-Fig4B_genes_inc_expr_NRF1-gene_name_NRF1 Rummagene Transcription Factor Associations 2026 1.0 null DA-35-DU85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.11994 AB-12-IS33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.00268 Low grade glioma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.147 GSE118816_2_v_3_myo1c_human RummaGEO Gene Perturbation Signatures 1.0 null DMRT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79667 GSE195663_0_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null X, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.27432 Adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.481 P4HB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09887 Nucleosome disassembly/reassembly complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.6 RBM41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50207 CE-18-AP85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.239063 LC-12-VN85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.71534 nucleus LOCATE Curated Protein Localization Annotations 1.0 null 42-MG-BA COSMIC Cell Line Gene CNV Profiles -1.0 -2.93416 GSE102870_7_v_0_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null Germ cell cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.043 Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A6SG-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARID5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77137 CRCGN015_HEPG2_48H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.02456 GSE236502_2_v_0_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null Immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.549 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6473-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A-CA-04-2009(H1N1)_48Hour_None_GSE40844 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.94799 BD-25-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.390341 B-16 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.734 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IR-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GA-88-CF36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.931939 GFM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94978 carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060917 CFAP36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3485 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A3LQ-01A-21R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pancreatic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.258 SD-82-GT69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.586266 XE-18-BC97_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.414654 KA-29-AB08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.29198 MB-15-ZF03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.58707 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6933-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-6981-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DDT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03755 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5098-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR1D1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.7996 Prostate adenocarcinoma_PRAD_TCGA-HC-7230-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE186440,GSE186443_0_v_5_daxx_human RummaGEO Gene Perturbation Signatures -1.0 null Carcinoma, Ovarian Epithelial DisGeNET Gene-Disease Associations 1.0 null BB-86-BE19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.79018 ZNF320 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 268.742 chemotherapy GeneRIF Biological Term Annotations 1.0 null Urinary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.756 FEV CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11824 TCTN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11735 outcome GeneRIF Biological Term Annotations 1.0 null QE-18-WG07_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.87304 NCI-H2009 COSMIC Cell Line Gene CNV Profiles -1.0 -2.93416 TE-26-XS06_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.436782 CRCGN015_HEPG2_48H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.96951 variant GeneRIF Biological Term Annotations 1.0 null AD-86-OB87_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.753335 QE-18-WG07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.422523 breast cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.12942 GE-47-OO30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.493688 Liver hepatocellular carcinoma_LIHC_TCGA-CC-5258-01A-01R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null S0-EE-Y6WJ_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.346505 Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NF-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BD-49-MD69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.488137 AC-30-XU83_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.65158 GSE216043_11_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null CF-48-QD87_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.483227 paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.36343 Brain Lower Grade Glioma_LGG_TCGA-DH-5140-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.745 Adrenocortical carcinoma_ACC_TCGA-OR-A5J8-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Organ system benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.111 FA-63-WI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -5.23785 PRKAA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64492 HCC1599 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.687085 AC-28-RT00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.976753 TA-19-YA45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.347621 CRCGN014_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.0564 CTCF_GM10266_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-R8-A73M-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARPC1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42862 cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.492359 Meningioma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.556 MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.29158 posterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.55215 CRCGN015_HEPG2_48H:I10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.1823 renal carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.170789 ME-31-RM40_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.705094 Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.623 CD4_Naive_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.899832 brain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 EE-02-BO83_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.340412 CA-25-LR28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.211889 PMC12178937-mmc6.xlsx-L_MAFF_KDvsL_C_deg_all-gene_name_MAFF Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A711-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:G03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.07885 PMC11003700-pbio.3002240.s013.xlsx-siMYCN_RNA_IMR32_48h_q_0_05_1_5-Table_S6_Genes_commonly_and_differentially_regulated_by_MYCN_and_WDR5_in_IMR32_cells_MYCN Rummagene Transcription Factor Associations 2026 1.0 null VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.956204 DD-54-MA35_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.409324 Brain cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.683 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7753-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TRAK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05318 GSE74251_0_v_1_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null WE-43-PZ45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.7793 OE-31-YC41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.18538 BF-79-GG96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.316906 POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3467-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Intrinsic component of endoplasmic reticulum membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.233 Renal cell carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.002 XB-35-TO54_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.200148 Lung squamous cell carcinoma_LUSC_TCGA-60-2711-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IKKA Kinase Library Serine Threonine Kinome Atlas 1.0 null Glioma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.239 POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE223893_11_v_9_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE143782_7_v_11_calcitriol_human RummaGEO Drug Perturbation Signatures -1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YW-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Vaccinia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.364 Small cell lung cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.816 NDUFS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02545 COLO 800 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.37477 Brain Lower Grade Glioma_LGG_TCGA-HT-A74J-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AE-39-DG66_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.299501 HC-92-HE59_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.695132 QE-79-XO29_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.602455 POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HRH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37959 MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE184087_2_v_3_tert_human RummaGEO Gene Perturbation Signatures -1.0 null KB-92-MK13_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.419398 head TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 G120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.05099 GSE160765_2_v_1_twist1_human RummaGEO Gene Perturbation Signatures -1.0 null superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3041 Lung squamous cell carcinoma_LUSC_TCGA-34-5927-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WEHI-3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.523 Autonomic nervous system neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.31 AA-99-HO76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.516877 Lung squamous cell carcinoma_LUSC_TCGA-60-2719-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE168171,GSE168173_0_v_1_ddx41_human RummaGEO Gene Perturbation Signatures -1.0 null CE-95-YX02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.355671 AB-25-XU75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.243361 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z2-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-ZJ-A8QO-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Immune system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.528 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D6-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.53 TSPAN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21391 JD-62-HR05_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.03714 Urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.601 CRCGN014_HEPG2_24H:P01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.26442 EA-18-FP00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.0933 Lung adenocarcinoma_LUAD_TCGA-55-8614-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null G121 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22758 CRCGN015_HEPG2_48H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.68919 BE-90-YK54_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.258274 HS6ST1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94448 insulin-responsive compartment COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.172 Mesothelioma_MESO_TCGA-SC-A6LM-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cribriform plate TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.543 MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24215 HCC44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.61144 GSE132369,GSE132371_5_v_0_cccp_human RummaGEO Drug Perturbation Signatures -1.0 null EC-89-AJ93_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.241472 ATOH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25892 bonemarrow_6c HPA Tissue Sample Gene Expression Profiles -1.0 -0.931149 GSE195568_3_v_0_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null 496100436_FWM_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.94335 USP54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.18432 VA-92-QP54_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.276872 Malignant Neoplasm DisGeNET Gene-Disease Associations 1.0 null DB-54-GQ68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.81153 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7103-01A-21R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AA-56-QO38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.283355 Ovarian Neoplasm DisGeNET Gene-Disease Associations 1.0 null Leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.674 DF-92-CF17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.209095 JE-22-JR20_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.245187 CF-48-QD87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.259778 Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JZ-01A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22758 spinal cord TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.130658 496100362_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -4.10615 HOXB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68515 Muscular dystrophy-dystroglycanopathy type C12 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.022 CF-03-QN99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.241719 BE-79-QU25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.845482 CRCGN014_HEPG2_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.07577 laterodorsal part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02462 liver_a HPA Tissue Sample Gene Expression Profiles -1.0 -0.861931 Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61O-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BC-13-OQ01_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.473448 GSE213228_2_v_5_irak2_human RummaGEO Gene Perturbation Signatures 1.0 null WE-41-YO44_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.293882 496100355_HIP_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.43636 BC-00-YH62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.590469 NE-00-JZ19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.364715 ZB-33-MZ40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.870852 GSE145639_1_v_2_adar_human RummaGEO Gene Perturbation Signatures 1.0 null GSE190316,GSE190324_10_v_9_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE102505_1_v_0_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13745 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A1QS-01A-61R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.96825 Prostate adenocarcinoma_PRAD_TCGA-J4-A6M7-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NE-34-OZ69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.552966 Adult Glioblastoma DisGeNET Gene-Disease Associations 1.0 null RUNX2 JASPAR Predicted Transcription Factor Targets 1.0 null Amygdala TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Lung squamous cell carcinoma_LUSC_TCGA-56-8082-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Squamous cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.787 FE-82-WB22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.36891 Prostate adenocarcinoma_PRAD_TCGA-J4-A67K-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null reuniens nucleus (medioventral nucleus) of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.928168 BB-87-SF89_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.70625 SRSF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06456 AA-52-JS03_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.204197 GSE174498,GSE174500_2_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null SCARB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89102 abducens nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.27418 Hepatobiliary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.822 Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HI-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BB-87-SF89_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.49255 AB-18-YN11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.503072 SG in posterior frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06546 GB-06-BA49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.13268 AD-00-WA10_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.360059 FD-91-OK66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.15005 SAR1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.113 RD-79-FH72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.484201 Mitoxantrone CTD Gene-Chemical Interactions 1.0 null POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null each GeneRIF Biological Term Annotations 1.0 null DD-36-YH76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.263411 Large intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.668 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RU-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral hypothalamic area, mammillary region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.99127 MAST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.174 EC-37-MB09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.270714 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BC-00-YH62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.827887 CP in caudal hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02071 RXRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 52.2797 DCTD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89637 CRCGN014_HEPG2_24H:I19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.04185 GB-46-CK08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.230864 hcc GeneRIF Biological Term Annotations 1.0 null CREB3L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8039 LXF-289 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.905635 DA-10-VU83_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.0347 GA-88-CF36_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.378504 HIF1A_01_87 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.65413 GSE149621_2_v_1_olaparib_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN014_HEPG2_24H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.15349 hybrid GeneRIF Biological Term Annotations 1.0 null SK23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.22053 Malignant Head And Neck Neoplasm DisGeNET Gene-Disease Associations 1.0 null DA-10-GX45_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.777526 DB-18-UF01_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.302584 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29V-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Stomach disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.597 PMC12534504-41598_2025_20489_MOESM1_ESM.pdf-418-ZEB2_ZEB2 Rummagene Transcription Factor Associations 2026 1.0 null inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.4119 CB-55-AK76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.228549 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Genes_differentially_expressed_upon_CSL_silencing_AR Rummagene Transcription Factor Associations 2026 1.0 null squamous epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.097851 outer SZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.920315 SNU-C1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0443 GSE202434,GSE202438_9_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null SPOTS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.895 Neural ectoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.699 abducens nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.83431 Skin cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.487 CRCGN015_MCF10A_48H:J24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.6054 Myeloid neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.25 AE-22-QI24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.816711 PPARA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38089 Multiple myeloma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.291 RD-90-OY66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.836336 Glioma stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.339 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MS-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null carcinogenesis GeneRIF Biological Term Annotations 1.0 null GSE119978,GSE180930_0_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null AU565 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.545839 AB-21-VE32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.00148 Rectum adenocarcinoma_READ_TCGA-DC-6157-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_3H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.62465 Ovary epithelial cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.102 GSE160817_5_v_8_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN017_MCF10A.TP53.M_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.7106 STXBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78572 Acute Myeloid Leukemia_LAML_TCGA-AB-2927-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ocular cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.017 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AU-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060824 GSE120612_4_v_3_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null OAW42 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.891136 Squamous Cell Carcinoma Of The Head And Neck DisGeNET Gene-Disease Associations 1.0 null GRK1 Kinase Library Serine Threonine Kinome Atlas 1.0 null spliced GeneRIF Biological Term Annotations 1.0 null PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1 Rummagene Transcription Factor Associations 2026 1.0 null LPAR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05882 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.877045 GSE245270_2_v_3_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-VN-A88Q-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null composed GeneRIF Biological Term Annotations 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null T2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.336 b16f0 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.051 AB-18-YN11_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.222581 nsclc GeneRIF Biological Term Annotations 1.0 null Neurosphere_Cultured_Cells_Ganglionic_Eminence_Derived Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.892283 JF-30-FW92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.943983 NF-21-HQ00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.03077 QE-93-PG25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.906408 KLF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 112.46 FHL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63592 carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.255241 Prostate adenocarcinoma_PRAD_TCGA-YL-A8SP-01B-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE143782_6_v_1_calcitriol_human RummaGEO Drug Perturbation Signatures 1.0 null Female reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.706 FB-49-NW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.475341 IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.959824 CTCFL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.457 ZE-45-CG69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.548992 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.23961 WE-41-YO44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.323131 HB-06-WU12_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.5894 496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.0137 CRCGN009_HEPG2_24H:I18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01899 VIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.886649 VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2885 III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.981337 QA-07-KC40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.32602 PAIP2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71823 KMT5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38019 BD-49-MD69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.0861 ZNF528 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.9123 HC-74-HM63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.399229 K562 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.79369 Malignant astrocytoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.848 VPS37C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33419