association	dataset	threshold value	standardized value
496100640_PCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07071
GSE100528_1_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MALME3M	DepMap CRISPR Gene Dependency	1.0	4.29452
PMC5354998__F10	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K60161601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28646
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.098
CRCGN009_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.8016
BRD-K58066822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4281
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.786708
protein insertion into membrane	GO Biological Process Annotations 2023	1.0	null
protein insertion into mitochondrial inner membrane from matrix	GO Biological Process Annotations 2023	1.0	null
TE6	DepMap CRISPR Gene Dependency	1.0	2.62786
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K21312826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62664
BRD-K65445351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69303
OVTOKO	DepMap CRISPR Gene Dependency	1.0	2.00321
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.317926
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.512533
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0079
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
OC-40-XI13_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271625
HNRNPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09346
BRD-A89471191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33963
DD-74-PJ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.423708
BRD-K95591068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07255
Autosomal dominant cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.431
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	3.52975
GSE118617,GSE118619_2_v_3_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6071_PARK7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.803975
GSE195663_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BARHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.4456
CRCGN014_HEPG2_3H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21145
5659_NGDN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.748903
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.5529
isoetharine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33331
GSE212312_2_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76645599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28251
BRD-A44990218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47354
BRD-K84310612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76494
BRD-K80803211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01972
BRD-K05122615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70497
GSE149264,GSE149267_2_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15785
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCDC88A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60595
BRD-K94273044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20062
XC-65-XN91_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205026
BRD-K41412255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22467
BRD-K40765512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83464
BRD-K60456515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08316
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
9909_XRCC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.711389
BRD-K26857129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37259
BRD-K89278382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06486
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K30853940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06541
BRD-K22720379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6701
protein insertion into membrane	GO Biological Process Annotations 2025	1.0	null
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K12376164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92673
BRD-K34009761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10338
TPRKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19416
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE127790_4_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264735
BRD-K52416366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15966
BRD-K80807286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46328
BRD-K07600484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60689
1141_CAAP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.512391
BRD-K82401173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34787
BRD-K16551475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95438
Lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.072
BRD-K69031148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76152
BRD-K89805365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1492
BRD-K03194507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35905
Trypanosomoid form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.067
GSE171180,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
MM160113	DepMap CRISPR Gene Dependency	1.0	3.29752
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4746
BRD-K43352598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09073
BRD-K22591777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14375
BRD-K88128293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53775
BRD-K31013025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70104
GSE147240_0_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K33503286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12061
GSE200352_1_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-19-JA87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272366
BRD-K33697018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68806
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE188721_2_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100457_TCx_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.04196
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4799
BRD-K84246050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08799
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.491637
PMC5354998__F10	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K37721603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93433
GSE179002_3_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0094
BRD-K93460493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53192
Arx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.3356
BRD-A46317335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.54964
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.034
PMC10123531-NIHMS1874945-supplement-Table_S7.xlsx-SOX17_BCAT_4TCFKO_peaks-Gene_Name_SOX17	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30917841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30892
BRD-K43981353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39505
protein localization to mitochondrion	GO Biological Process Annotations 2025	1.0	null
BRD-K13922961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18579
BRD-K11003742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59921
GTEx Muscle 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	-1.0	-9.88977
BRD-K56783915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12111
BRD-K95653016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49279
BRD-K88328128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34504
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55985
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.5417
BRD-K15876355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.202
GSE211177,GSE211178_0_v_1_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K96807219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43944
BRD-K91944762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12636
BRD-K69984954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64175
BRD-K30462643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47569
GSE196540,GSE196542_4_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K89199943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10632
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.674
protein insertion into mitochondrial membrane	GO Biological Process Annotations 2025	1.0	null
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.434682
Sleep disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.674
CRCGN016_MCF10A.TP53.M_24H:G17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14039
PMC9170821-JCMM-26-3183-s001.xlsx-Oligo_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
CFAP36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02736
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZMYND11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10742
BRD-K82399478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29142
BRD-K23956364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5927
BRD-A17831693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0129
EA-18-FP00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229254
BRD-K66013406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0403
BRD-A90462498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0216
BRD-K54495109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19217
BRD-K71007902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71826
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A28932952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17672
BRD-K54384984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08815
MRPS14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93412
BRD-K92446632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63637
H3-5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13593
BRD-K98264372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10429
CRCGN015_MCF10A.WT.HP_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21179
BRD-K50068274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54867
HEATR5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01131
Sleep duration	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.769897
BRD-K66401298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49329
BRD-A56909893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03427
BRD-K37892442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04023
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K94962273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00219
NEUROD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4669
CE-23-HP88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24119
PLEKHH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41183
BRD-K93933512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08813
BRD-K60557007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08271
496100340_TCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.87157
BRD-K54837058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0944
intracellular organelle lumen	GO Cellular Component Annotations 2025	1.0	null
BRD-K34423419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0744
Heart disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.985
BRD-A88381870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98276
AE-85-KE62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262528
GSE57871_5_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EmrE multidrug transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.322
CRCGN016_MCF10A.TP53.M_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.94436
BRD-K69543414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66447
BRD-A84867566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37713
BRD-K31546068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49339
BRD-K56595246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12276
BRD-K44224150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98599
BRD-K15502859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91224
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.365382
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0677
BRD-K80766355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11085
Autism spectrum disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.325
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
SA-32-CC58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202949
methionine-importing ABC transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.735
CRCGN015_MCF10A.TP53.M_24H:G22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0042
BRD-K64055724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06439
BRD-K12064774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15474
PRMT8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00494606
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K60353472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00169
BRD-K97867712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62633
BRD-K51577368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23647
GSE134412_0_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185139_1_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K81982648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.339
BRD-K17675924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81312
BRD-K00086692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53068
BRD-K22216962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57682
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5057
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.48945
BRD-K93153656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02324
BRD-K97526959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19813
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9198
BRD-K31747470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44845
HC-63-SV27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278128
3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.959
PLA2G1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00569144
GLOD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09538
BRD-K31197843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71184
BRD-K30992744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62361
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4502
LN235	DepMap CRISPR Gene Dependency	1.0	4.20368
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.749872
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4653
HEC59	DepMap CRISPR Gene Dependency	1.0	2.25538
Heart conduction disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.985
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171179,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_1_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K51253991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25282
HNRNPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49425
BRD-K59708864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0645
BRD-K41548770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48869
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.131
HCC70	DepMap CRISPR Gene Dependency	1.0	2.09843
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.35792
BRD-K65789952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27324
CRCGN009_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71213
BRD-K75583553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3034
GTEx AdiposeTissue 20-29 vs 30-39	GTEx Tissue-Specific Aging Signatures	-1.0	-6.08409
SLC8B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16381
GSE194396,GSE194429_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K74754874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8545
BRD-K26161397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20262
BRD-K11493601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22147
Mitochondrial proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.907
BRD-K02240568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14856
BRD-K65969715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04086
BRD-K02061146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44336
BB-87-SF89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210021
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6364
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.2545
CRCGN017_MCF10A.WT.HP_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00245
IKZF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44673
FOXD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37768
BRD-K17152303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21776
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Rarg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	68.5528
BRD-A52794651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32455
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.918
BRD-K08715918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21344
GSE199255,GSE199356_4_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206342_1_v_0_kpna2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28707
Cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.288
BRD-K56520977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18085
TIM23 mitochondrial import inner membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.029
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5711
PAFAH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28474
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213519
TMEM119	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00642621
BRD-K21327356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4502
OE-89-FS84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227323
mitochondrial calcium ion transmembrane transport	GO Biological Process Annotations 2023	1.0	null
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3111
FLAD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572256
GSE123825_2_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K32208085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12028
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5268
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.82786
CRCGN008_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.8277
BRD-K96623405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35357
BRD-A27080191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19326
MAPK12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14571
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.490238
BRD-K40894545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.81656
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RT11284	DepMap CRISPR Gene Dependency	1.0	2.40925
BRD-K88812218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21173
BRD-K67740871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.62021
BRD-K39087168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48693
IF-31-RN78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.354118
BRD-K09328667	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41187
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.852256
Schizophrenia	DisGeNET Gene-Disease Associations	1.0	null
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.97165
Mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
496100358_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.35128
BRD-K61072684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12952
CRCGN010_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8375
BRD-K11630986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18726
BRD-K06408981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28529
LPS510	DepMap CRISPR Gene Dependency	1.0	2.72405
BRD-K38917645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03553
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Arid5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.4928
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.382763
Excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Intrinsic component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.096
PMC8563805-41598_2021_858_MOESM2_ESM.xlsx-Supplementary_Info_6-Gene_List_6_The_list_of_human_orthologs_of_the_downregulated_fly_DEGs_identified_from_TRAP_control_vs_PARIS_wild_type_comparison_ZNF746	Rummagene Transcription Factor Associations 2026	1.0	null
protein insertion into mitochondrial membrane	GO Biological Process Annotations 2023	1.0	null
Mitochondrial small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.751
FAM78A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0057421
2132_DDX56_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.641701
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Endopeptidase Clp complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.558
BRD-K98704738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29597
BRD-K14778436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58859
BRD-K87465930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00311
FAM78A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2035
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K34232791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70123
BRD-K74948793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07935
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7254
BRD-K10925833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19603
BRD-K42475945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01518
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01774
BRD-K62511698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83619
BRD-K17293545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06736
Spinocerebellar ataxia type 28	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.95
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
m4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.997
BRD-K33760911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75031
PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K72437469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30318
BRD-K44415466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06874
GTEx AdiposeTissue 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-13.8534
GSE147664_0_v_1_arid1b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81174
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.62846
BRD-K12260863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28746
CRCGN008_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0943
PLIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06449
TRPC4AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04435
BRD-K41798816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55497
BRD-K53665750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71059
SOX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4605
ATOSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01214
Hereditary spastic paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.445
BRD-K97929312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31849
BRD-K26156776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12177
Stat6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.9681
HS695T	DepMap CRISPR Gene Dependency	1.0	7.39951
BRD-K25645002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53278
BRD-K69073616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30611
BRD-K91712163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33498
BRD-K18515345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01977
CRCGN015_MCF10A.TP53.M_24H:G17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12295
FB-39-CW59_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.296289
Gata3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.0949
BRD-K50315405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70925
BRD-A50837272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2264
RA-49-ZB08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209778
CRCGN016_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1846
CRCGN016_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.83941
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05578
RFX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12594
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256133
BRD-K61772027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49165
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5957
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K34425773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86343
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209741
KE-07-JX81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225906
CRCGN017_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51571
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.342295
intracellular calcium ion homeostasis	GO Biological Process Annotations 2023	1.0	null
BRD-K46639367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60245
BRD-K05465626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07504
GSE146045_1_v_0_lama3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16858
BRD-K49656278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60669
BRD-K08489825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40601
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.487369
BRD-K86102179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03868
KD	DepMap CRISPR Gene Dependency	1.0	2.52012
PFSK1	DepMap CRISPR Gene Dependency	1.0	2.10583
PMC8563805-41598_2021_858_MOESM2_ESM.xlsx-Supplementary_Info_8-Gene_List_8_The_list_of_human_orthologs_of_the_downregulated_fly_DEGs_identified_from_PARIS_C571A_mutant_vs_PARIS_wild_type_comparison_ZNF746	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A04691170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29274
BRD-K28320832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00601
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K47754225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02661
BRD-K01577807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49905
Intrinsic component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.094
BRD-K49368687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93497
BRD-K80895505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1382
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K86587289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60917
CRCGN009_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.73141
Intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
FE-64-KC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.694806
Flotillin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.753
CCT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91454
BRD-K78886448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43115
GSE248858_1_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243683
7785_SEPTIN2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.03934
BRD-K16954129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57913
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.35244
1578_CHML_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.808525
PFN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22669
Mitochondrial prohibitin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.736
BRD-K66572611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57759
m-AAA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.946
CRCGN014_HEPG2_3H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.202
CRCGN011_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1493
BRD-K51897928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22059
BRD-K11423211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61037
BRD-K43295075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20827
PSMB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24695
GSE157777_2_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169697,GSE169725_0_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K12347309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28565
PSS008	DepMap CRISPR Gene Dependency	1.0	4.74409
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.330191
DE-01-HO61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208811
CRCGN014_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2595
Optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
CRCGN011_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7881
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.276
BRD-K39140255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38883
BRD-K32879108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02807
GSE216394_2_v_0_pfkp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186620_0_v_1_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K81574470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21203
CRCGN017_MCF10A.WT.HP_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.50705
YY1-26981420-C2C12-MOUSE-MUSCLE	ChEA Transcription Factor Targets 2022	1.0	null
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K08533345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58265
BRD-K96637144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08582
BRD-A57457448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26668
496100639_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15311
ACCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36895
BRD-K49298555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31296
BRD-K46839342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10758
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3857
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217491
BRD-K79829201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44671
i-AAA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.588
BRD-K09842906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11944
5964_LTO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.1892
BRD-K23241743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24719
CRCGN015_MCF10A.WT.HP_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20939
HSD17B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68897
Organellar small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.75
BRD-K30269093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71545
BRD-K89089981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62146
TMEM128	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12145
Bb	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.912
Mitochondrial respiratory chain complex III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.644
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.762917
GSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9168
EN	DepMap CRISPR Gene Dependency	1.0	2.98847
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K56057104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73365
BRD-K32913479	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41092
CRCGN010_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25135
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225688
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1204
PHLPP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39155
BRD-K36847650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55647
BRD-K42797038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08166
BRD-K11476310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.64065
ERG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10542
BRD-K28512751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55237
CBX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04778
BRD-K47261271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.408
BRD-K06152379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15951
BRD-K44955380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03477
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.436035
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.3764
BRD-K62463442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31821
BRD-K75243062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6556
organelle inner membrane	GO Cellular Component Annotations 2023	1.0	null
BRD-A59009217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20286
BRD-K83459401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19123
BRD-K12959846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50453
BRD-K79334072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14876
GSE172020_0_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K97371424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69222
BRD-K44004565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41315
BRD-K20416270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2798
BRD-K79204912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41682
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.666843
NCCMPNST1C1	DepMap CRISPR Gene Dependency	1.0	2.29929
NCIH1573	DepMap CRISPR Gene Dependency	1.0	3.78895
BRD-K52194153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78927
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
mitochondrial matrix	GO Cellular Component Annotations 2025	1.0	null
BRD-K02625776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19129
BRD-K86792405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21132
BRD-K92712225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32334
GSE241701_4_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86104966	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02385
GSE228106_0_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Valproic acid sodium salt_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014167
BRD-K87479423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23949
BRD-K93008833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41652
MICOS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.63
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.3023
GSE127790_10_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Spastic ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.824
BRD-K02783902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72665
BRD-K09693670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52268
BRD-K08679933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5654
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MIGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21097
BRD-K49847771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02248
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
AGXT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9274
FAM241B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08205
BRD-K14394756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11679
BRD-K05837079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4388
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K01351858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85616
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505518
BRD-K03262163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50608
BRD-K14653235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.43625
CRCGN008_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08
RAB1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02751
BRD-K86036680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81726
GSE240896,GSE240899_3_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_7_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.417869
LAMA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01977
CDC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02822
THRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.1755
BRD-K11414036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16899
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.85925
UMUC16	DepMap CRISPR Gene Dependency	1.0	5.75336
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6297
Stomach	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K64425085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50057
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.5857
LCAM1	DepMap CRISPR Gene Dependency	1.0	2.38387
BRD-K16312305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55636
Transcription export complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.907
PACADD188	DepMap CRISPR Gene Dependency	1.0	4.19475
mitochondrial membrane organization	GO Biological Process Annotations 2023	1.0	null
EFM19	DepMap CRISPR Gene Dependency	1.0	2.37656
MAVER1	DepMap CRISPR Gene Dependency	1.0	2.14234
CB-46-FO63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220138
10244_ZNF260_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.947448
496100395_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.12906
BRD-K11566857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38999
CRCGN008_HEPG2_24H:A04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3092
BRD-K32124229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40418
FOXH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12735
HEATR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08404
GSE190235_1_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DHRS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490993
BRD-K35646839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30353
NR3C2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00521817
GSE215086_5_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAP3K5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00474946
GSE249146_2_v_1_dusp6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K10784927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.336
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.373827
inner mitochondrial membrane organization	GO Biological Process Annotations 2023	1.0	null
GSE193258,GSE193259_2_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXC13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6423
BRD-K92462786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00811
CRCGN016_MCF10A.TP53.M_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35914
BRD-K52838863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09858
BRD-K44760023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13806
CRCGN011_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6936
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.325
BRD-K79904333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1872
CCDC174	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48664
BRD-K53540914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32562
Bone marrow	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.041
TTC642	DepMap CRISPR Gene Dependency	1.0	5.35793
GSE225901_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214517
HNF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81955
BRD-K15047839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40799
CRCGN017_MCF10A.WT.HP_24H:G17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44415
deferoxamine-mesylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10008
Mitochondrial matrix	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K60337438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22986
TTC30A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14392
BRD-K55665639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15941
RPL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72383
mitochondrial membrane	GO Cellular Component Annotations 2023	1.0	null
BRD-K71944493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11938
BRD-K84956158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0117
Obstructive lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.131
CRCGN010_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.74971
MBTPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39133
BRD-K01452910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25086
BRD-K82244940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34272
HE-16-PO98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245451
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253282
BRD-K19969409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57986
BRD-K85525164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66592
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5982
BRD-K58715359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.56088
BRD-K41347678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93372
BRD-K56301498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68865
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cyclopamine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
BRD-K09473191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91533
GSE112760,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DB-41-IH69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200416
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0204
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247893
BRD-K02180800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87476
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4359
BRD-K98251998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37767
BRD-K97761115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80483
BRD-K92544320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62409
BRD-K19009595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00084
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293343
HA1E	DepMap CRISPR Gene Dependency	1.0	3.06512
496100551_PCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.60154
BRD-K65464642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29481
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PLEKHA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13839
BRD-K54931539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04298
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5571
BRD-K01467488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46545
GSE213996_1_v_0_fhl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K32084247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3355
BRD-K01805176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73352
BRD-K20644549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18416
BRD-K15341710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25666
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.795
BRD-K29992178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17773
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.2955
AARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47433
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
Organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K08618283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0399
mitochondrial calcium ion transmembrane transport	GO Biological Process Annotations 2025	1.0	null
7581_RSU1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.533086
BRD-K92955882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35695
GSE196540,GSE196542_2_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SHSY5Y	DepMap CRISPR Gene Dependency	1.0	2.02592
CRCGN016_MCF10A.TP53.M_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45119
GSE164874_5_v_14_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K75506133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17451
BRD-K58140298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53139
BRD-K08174111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76662
AA-67-TF79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212589
5910_NXF1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03656
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9506
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EXOSC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29018
BRD-K99462197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99283
mitochondrial calcium ion homeostasis	GO Biological Process Annotations 2023	1.0	null
BRD-K33179234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14501
TFRC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586482
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HRH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28804
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.4949
mitochondrial transport	GO Biological Process Annotations 2023	1.0	null
BRD-K90526956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34331
ISHIKAWAHERAKLIO02ER	DepMap CRISPR Gene Dependency	1.0	4.53099
BRD-K24532125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6623
BRD-K76515685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16832
PI4KB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24686
BRD-K71427375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51472
BRD-K37900095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0913
intracellular protein transport	GO Biological Process Annotations 2023	1.0	null
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.7059
MTERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00013
DNA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14283
GSE109530,GSE109531_1_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HUH7	DepMap CRISPR Gene Dependency	1.0	2.19807
BRD-K18128277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3731
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Lower respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.131
ZBTB33	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8894
BRD-K72721410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.29718
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8218
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE179974_3_v_0_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.934
CRCGN016_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29357
BRD-K00020149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16052
BRD-A12894472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10681
CRCGN016_MCF10A.TP53.M_24H:E14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07407
GTEx Colon 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-18.6513
SNRPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3201
BRD-K32120119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2948
GSE183113_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1694
BRD-K75844518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02927
BRD-K19085288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47824
BRD-K43926323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63947
BRD-K82112239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13403
CRCGN009_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08085
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K26634905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33854
BRD-K14723547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.224
GORASP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73874
BRD-K56283394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22152
CD-16-KY17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.34818
IA-27-CK10_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328034
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8752
GSE201042_2_v_1_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
J82	DepMap CRISPR Gene Dependency	1.0	2.62388
GSE127790_9_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.89546
BRD-K82506716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18643
Mitochondrial large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.662
DU4475	DepMap CRISPR Gene Dependency	1.0	2.83156
CRCGN014_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07645
BRD-K82376876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.018
MA-88-CA03_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.309405
CRCGN016_MCF10A.TP53.M_24H:F11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11088
pridinol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34405
BRD-K90103010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44925
CDAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39501
BRD-K09720842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31688
BRD-K05135707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09645
CRCGN016_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63859
BRD-K63920153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89638
BRD-K09166899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26305
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A90969585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40834
BRD-K27194553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35773
TCTA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00510832
ZNF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00411
BRD-K38766433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2804
protein localization to mitochondrion	GO Biological Process Annotations 2023	1.0	null
BRD-K18268126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55306
BRD-K92212152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4252
BRD-K63809385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33932
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
BRD-A26640795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08639
BRD-K77354492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44784
GTEx AdiposeTissue 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	-1.0	-7.5373
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.514896
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2221
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.57506
BA-15-VE07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224906
BRD-K17649115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90537
BRD-K04568082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4811
Spastic ataxia 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.596
BRD-K72707702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25933
BRD-K28354175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86281
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178227_1_v_2_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K47821225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81562
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257498
5005_METTL4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.620985
Irf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.0121
intracellular organelle lumen	GO Cellular Component Annotations 2023	1.0	null
BRD-K80336250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37206
BRD-K35587518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.35934
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	1.0	1.42476
Pervasive developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.325
Mammary ductal carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.504
BRD-K42943023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19141
ACHN cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.962
BRD-K89742282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26085
BRD-K67609710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69109
GSE57871_5_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.28646
BRD-K50092006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16638
BRD-K99413603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65558
Brain - Cerebellum	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.809958
BRD-K67572910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10785
BRD-K31325635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04283
CRCGN014_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24392
GSE228727_2_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
9910_XRN1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.524014
BRD-K39435284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04537
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.280904
BRD-K14863829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00535
FA-36-VA24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22704
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Breast invasive ductal carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.514
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:M24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1815
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.51868
GIMAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0045512
UV-sensitive syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
BRD-K95160020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04177
AB-80-CK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200955
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K68072222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30637
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K79433629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87072
Chronic obstructive pulmonary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.131
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2107
BRD-A92490200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34512
B-lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.072
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1315
NR2C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16479
NOMO1	DepMap CRISPR Gene Dependency	1.0	2.76413
GTEx Heart 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	-1.0	-8.76467
ZNF35	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6868
BRD-K78944047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01439
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K69718434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04552
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2139
RPAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83102
BRD-K39752756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46697
CRCGN016_MCF10A.WT.HP_24H:L24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34584
BRD-K16598630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57375
BRD-K24443173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61957
BRD-K29806938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18587
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11696795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57658
BRD-K97257286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58237
496100388_HIP_probable Alzheimer's disease_no TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01389
CUX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07994
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MTPAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0548
CCC5	DepMap CRISPR Gene Dependency	1.0	3.49617
HD-62-KE69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227328
BRD-K69355244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23794
BRD-K72359187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01737
SPSB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5116
BRD-K98161738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1254
BRD-K94766933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44793
BRD-A52377240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01604
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K90625628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41666
GSE202434,GSE202438_4_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K34445094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0065
CRCGN016_MCF10A.TP53.M_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14004
BRD-K02210445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01457
mitochondrial inner membrane	GO Cellular Component Annotations 2023	1.0	null
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GNL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59749
BRD-K41272069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50057
BRD-K06718330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14048
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K58680513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28257
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206201
BRD-K03308716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32634
BRD-K32925057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6495
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2564
NGP	DepMap CRISPR Gene Dependency	1.0	2.28119
BRD-K39016838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71153
BRD-K71251432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43882
Kidney	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_HEPG2_48H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21625
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2641
NCO2	DepMap CRISPR Gene Dependency	1.0	3.36665
GSE95685_2_v_5_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LY6G5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51128
BRD-K90571714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79645
BRD-A09961470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06929
GSE143462_0_v_1_omipalisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5433
3-methylglutaconic aciduria with cataracts, neurologic involvement and neutropenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.587
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4851
BRD-K66408914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05056
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5899
CRCGN016_MCF10A.TP53.M_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.144
BRD-A69950438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10035
7312_RIOK2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.526992
BRD-K24124047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06297
Cardiovascular system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.985
BRD-K82852523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06668
Integral component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.22
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_6_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
SAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31782
BRD-K56161905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28073
Mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
BRD-K78493876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29857
BRD-K41323747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10687
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220284
ATPAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99011
BRD-K24496049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21743
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K11705648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10507
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7754
POLE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59765
BRD-K85851814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65405
CRCGN014_HEPG2_24H:B03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.91115
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4634
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K73145196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23482
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3491
BRD-K28916436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03456
BRD-K97682096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85271
SACM1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15189
ZFP36L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00642794
BRD-K69443135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03884
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE167224,GSE168147_3_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PTAFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00537061
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4254
BRD-K82397896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09315
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2684
BRD-K27265817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49264
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3359
D425	DepMap CRISPR Gene Dependency	1.0	4.78121
BRD-A57762296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25676
BRD-K79547691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32441
CNPPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52577
BRD-K66675422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3506
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02325
BRD-K35156336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50748
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.2653
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0632
BRD-K95875837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66477
BRD-K42529194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22912
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3966
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K58242935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69848
ZNF536	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44787
GSE193258,GSE193259_9_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K42809349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40646
GSE112760,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2747_ESYT1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563893
BRD-K79020643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10886
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337724
BRD-K01668149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14482
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207188
GSE142019,GSE142021_10_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214212_2_v_0_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEx Muscle 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-23.3602
BRD-K60830482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3174
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147240_0_v_7_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1193
BRD-K94082609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19114
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	1.0	null
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.33414
BRD-K91516693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39885
ribosome binding	GO Molecular Function Annotations 2023	1.0	null
MRGPRX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00504726
BRD-K31081052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71725
GSE113952,GSE113953_1_v_0_chtop_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3772
BRD-K98944347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73433
protein insertion into membrane from inner side	GO Biological Process Annotations 2023	1.0	null
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76551930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0776
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59948
GSE123825_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Protein phosphatase 4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.618
BRD-K06834318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26806
BRD-K29408413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31618
BRD-K35963610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2205
RMGI	DepMap CRISPR Gene Dependency	1.0	2.22187
BRD-K14732815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10754
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.750659
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7184
CDC42SE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35643
BRD-K44828787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96255
BRD-K81006490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01913
BRD-K09721867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24177
BRD-K72997741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10481
BRD-K87107091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20712
CIT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00543216
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4509
HT144SKINFV2	DepMap CRISPR Gene Dependency	1.0	2.30184
GSE185519_1_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K25844701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1854
JC-02-ZR15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222502
mitochondrial membrane	GO Cellular Component Annotations 2025	1.0	null
BRD-K99452971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54641
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Cytochrome b6f complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.616
BRD-K19381111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53468
GSE191174_0_v_1_ccdc92_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HSPA12B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66023
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11906354-41588_2025_2087_MOESM4_ESM.xlsx-ST12-Unnamed_3_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Heart - Left Ventricle	GTEx Tissue Gene Expression Profiles 2023	1.0	1.80585
BRD-K80888333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38364
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K72435943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35363
BRD-K91225366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84513
RIPOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89282
GSE214931_4_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTF3C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25855
BRD-K23430405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17426
GSE203308_14_v_5_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K17300786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46237
GRM7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00690118
496100538_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16533
SLC36A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00643343
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A91891312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74955
BRD-K45101864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18136
PMC11185845-NIHMS1996282-supplement-Table_S1.xls-TableS1_txt-Kasumi_miR130_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135352_2_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CE-69-HJ13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209897
PGRMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00426
PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
RVH421	DepMap CRISPR Gene Dependency	1.0	3.22493
CRCGN015_MCF10A.WT.HP_24H:H20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00256
BRD-K53559383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61648
BRD-K02675272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01368
BRD-K15515777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24329
BRD-K83115645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47567
Multimerin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.106
BRD-K50216418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45197
BRD-K06475437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46283
NVL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49332
BRD-K46401069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33969
protein insertion into mitochondrial inner membrane from matrix	GO Biological Process Annotations 2025	1.0	null
BRD-K52017042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08227
496100478_HIP_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.92934
AD-91-LE02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262392
BRD-K99644502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19948
BRD-K48255349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33215
BRD-K27372445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.69658
SET2	DepMap CRISPR Gene Dependency	1.0	3.85346
BRD-K53647637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44024
BRD-K69158240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6508
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.45885
BRD-K68270916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60465
BRD-K61590534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18514
BRD-K43126701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62113
GSE162276_4_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SCMCRM2	DepMap CRISPR Gene Dependency	1.0	3.0743
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.355877
Lhx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.2349
PMC10624900-41467_2023_42825_MOESM13_ESM.xlsx-Module_3-ZNF195_ZNF195	Rummagene Transcription Factor Associations 2026	1.0	null
THAP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66831
BRD-K02565327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24318
BRD-K89377615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04613
CRCGN015_MCF10A.TP53.M_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1822
BRD-K68459574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00477
BRD-K77273085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8189
BRD-K32949071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47994
establishment of protein localization to mitochondrial membrane	GO Biological Process Annotations 2025	1.0	null
CRCGN016_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26285
IAH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41639
PPP2R5E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32452
CRCGN015_MCF10A.WT.HP_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01409
CRCGN015_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3474
BRD-K85604751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11386
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.400574
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.5556
BRD-K82284644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19245
BRD-K68575551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30018
TNNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6236
BRD-K67036882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62379
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K63271817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38348
GSE169152_5_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171837_1_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20451745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25653
BRD-K17765399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99835
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9621
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular calcium ion homeostasis	GO Biological Process Annotations 2025	1.0	null
mitochondrial matrix	GO Cellular Component Annotations 2023	1.0	null
BRD-K77207661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18891
GSE234043_0_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K19039785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67716
CCDC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62041
establishment of protein localization to mitochondrial membrane	GO Biological Process Annotations 2023	1.0	null
GSE157233_2_v_4_a1cf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13892
R3HDM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00796
BRD-K81916372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.019
NOS1	DepMap CRISPR Gene Dependency	1.0	2.33533
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24264
CAKI2	DepMap CRISPR Gene Dependency	1.0	4.90822
LN319	DepMap CRISPR Gene Dependency	1.0	3.39306
BRD-K06439119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52632
BRD-K76087207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12765
Transport of small molecules	Reactome Pathways 2024	1.0	null
GSE167886_3_v_1_chd7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K16231990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.47573
LAN2	DepMap CRISPR Gene Dependency	1.0	4.25835
Charcot-Marie-Tooth disease axonal type 2F	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.111
BRD-K37276417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.57378
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237999
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HIRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66282
GSE221633_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.163
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241078
MRPL21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07912
SAP30BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65066
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.2687
Lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.131
BRD-K51697315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20269
BRD-K12578029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47026
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
PF-39-DY68_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294452
BRD-K55727377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61169
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4321
BRD-K10871135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12482
BRD-K26503698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41175
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203075
FAM193B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47452
Organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.858
BRD-K67092184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26989
BRD-K87358945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5496
GSE216273,GSE216292_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE183251_1_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K32223081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16866
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.7943
GSE158320,GSE183351_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EEF1AKMT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30651
BRD-K18801549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.92512
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K76450447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17807
PHLDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05063
KD-31-TU05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216198
BRD-K94888615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05295
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.724437
BRD-A15086915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45238
BRD-K77797589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3402
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.515125
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.3192
BRD-K38617061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69739
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.604835
CRCGN008_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0771
GSE132386_1_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Organelle inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
BRD-K31666794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09066
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K58756877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38363
GSE149264,GSE149267_9_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7583
BRD-K17136501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03508
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.7194
BRD-K36289678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28741
BRD-K63908919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03878
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.493838
EE-98-PF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.448252
BRD-K74842791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29211
BRD-K17303020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13352
BRD-K25757432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17454
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47575
AATF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29478
BRD-K00976973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04413
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_3_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K91577886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05057
BRD-K58985886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18252
MTFR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2056
BT16	DepMap CRISPR Gene Dependency	1.0	4.0688
calcium import into the mitochondrion	GO Biological Process Annotations 2025	1.0	null
PMC11462941-CAS-115-2947-s001.pdf-136-HES1_HES1	Rummagene Transcription Factor Associations 2026	1.0	null
HEYL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17717
BRD-K91011325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23627
GSE162688_3_v_4_pink1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6024_PABPC1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.662277
CRCGN014_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.62139
CCK81	DepMap CRISPR Gene Dependency	1.0	5.44241
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K51934291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03948
ribosome binding	GO Molecular Function Annotations 2025	1.0	null
BRD-K46119789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18567
BRD-K39715006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04392
GSE146247_0_v_1_sirt7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K25016708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49964
BRD-K74626943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07929
GSE153354_0_v_1_tcf19_human	RummaGEO Gene Perturbation Signatures	1.0	null
AB-84-PK04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227505
GSE233679_14_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PI4KB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00323216
BRD-K25649596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30811
ADCK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539605
CRCGN017_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2123
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.483243
CRCGN016_MCF10A.TP53.M_24H:D18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.11028
BRD-K93503664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24931
BRD-K74267000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33998
GTEx Muscle 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-10.1038
GSE127790_11_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dg1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.898
BRD-K51140037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24526
CRCGN015_MCF10A.TP53.M_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00535
BRD-K90962922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24422
GSE200982_0_v_2_plac8_human	RummaGEO Gene Perturbation Signatures	1.0	null
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2797
Cloprostenol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
BRD-K30661365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36326
CRCGN015_MCF10A.TP53.M_24H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6305
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
SENP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41049
GSE201309_1_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339085
BRD-K56341841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25244
FB-66-UU47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294482
BRD-K26163290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69213
inner mitochondrial membrane organization	GO Biological Process Annotations 2025	1.0	null
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.432894
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351662
BRD-K41853443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53867
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_2_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K51754677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14504
BRD-K44936922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40092
BRD-K85803608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21755
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH28	DepMap CRISPR Gene Dependency	1.0	2.35029
BRD-K60862683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07663
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.52653
BRD-K56895780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5051
BRD-K68470956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45359
GSE162276_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310712
BRD-K68060538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41334
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.92366
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100485_PCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.65534
PEX26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18039
RASSF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04265
AD-51-FB60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.590973
BRD-K06250424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70901
BRD-K97348029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55036
BRD-K43594798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27778
GSE101112_6_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TCEAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07275
BRD-K55853030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08538
BRD-K07489055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31285
mitochondrial inner membrane	GO Cellular Component Annotations 2025	1.0	null
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01691
BRD-K57516590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60994
BRD-K29756429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4427
OA-54-FL10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.333942
CRCGN008_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47985
BRD-K00816476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30261
OC-10-FB51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228699
ZNF730	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03895
BRD-K45916030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14246
CRCGN016_MCF10A.WT.HP_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26913
GSE210655_1_v_7_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.985
BRD-K81821040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32464
ASGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27869
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.73455
Integral component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.219
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8255
BRD-K76755209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00435
BRD-K36782804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4937
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K93491540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9756
ACOT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32172
TC205	DepMap CRISPR Gene Dependency	1.0	2.49473
BRD-K95365728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27388
GTEx BloodVessel 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-19.2242
BRD-K11297155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91478
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8283
BRD-K49328983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28963
BRD-K50066702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08332
496100312_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.05139
BRD-K39489370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37533
GSE123022,GSE123030_2_v_6_trem2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233976
CRCGN014_HEPG2_3H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1912
DA-83-IZ87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227631
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A27407220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13116
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K72317601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69741
BRD-K26376097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50059
BRD-A73635700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60727
BRD-K47456612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34827
EC-98-YS67_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258653
BRD-K38131403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68631
BRD-K12986423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06123
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K84586608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93254
BRD-K39318389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33179
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.985
BRD-K16879434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62595
BD-96-HO33_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269717
BRD-K23543737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.87619
BRD-K21355275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79351
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
MEOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58592
Bipolar disorder lithium response (continuous) or schizophrenia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
Mitochondrial calcium ion transport	Reactome Pathways 2024	1.0	null
MED17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17638
SLC19A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11731
BRD-K42139332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87151
JHUEM1	DepMap CRISPR Gene Dependency	1.0	4.31387
Organellar large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.656
GSE167224,GSE168147_1_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.84285
ANKIB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26167
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.80366
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.750009
Urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
R3HCC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5361
CRCGN015_MCF10A_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19372
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
Inner mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.483
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
GSE135400_1_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
BRD-K03851221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29935
BRD-K84423439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21091
GSE134375_0_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7888
BRD-K50477983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23664
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210150_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K76812105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34289
mitochondrial calcium ion homeostasis	GO Biological Process Annotations 2025	1.0	null
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Choanomastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.562
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.72752
CRCGN014_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9517
calcium import into the mitochondrion	GO Biological Process Annotations 2023	1.0	null
BRD-K77554584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1677
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207479
SK-N-DZ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.762
BRD-K74317118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06534
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.97665
BCKDHA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17721
BRD-K39705203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09365
BRD-K79221878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52067
GSE182680,GSE182683_0_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.528103
BRD-K09261379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70108
GTEx AdiposeTissue 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-15.9426
BRD-K26866198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95113
WC-59-RG09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319227
NO11	DepMap CRISPR Gene Dependency	1.0	3.03115
BRD-K43684831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11483
BRD-K18657361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07466
BRD-K10571700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9351
RHOXF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.137
IMR32	DepMap CRISPR Gene Dependency	1.0	2.04025
CRCGN017_MCF10A.TP53.M_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45695
BRD-K86884344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03603
BRD-K34311186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00344
BRD-K42671261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84743
BRD-K81660107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77755
GSE258991_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
pi1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.553
A673	DepMap CRISPR Gene Dependency	1.0	5.01683
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.373947
SESN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16241
BRD-K83801418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23838
GSE226285_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
methionine-importing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.733
BRD-K11674021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73156
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.03913
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12047497-mmc5.xlsx-Sheet1-GSE20754_WT_VS_TCF1_KO_MEMORY_CD8_TCELL_UP_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
BIN67	DepMap CRISPR Gene Dependency	1.0	2.10864
BRD-K18181387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35537
BRD-K51927648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61789
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.79009
HUO9	DepMap CRISPR Gene Dependency	1.0	2.41505
ATP6V1C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58483
Small intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K79777851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22572
AP2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14123
BRD-K86240647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.58159
BRD-K76337122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06672
GSE152441,GSE152442_6_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A42612443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78406
CRCGN015_MCF10A_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23005
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-66-NV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315217
BRD-K95294904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28686
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.2637
NZM42	DepMap CRISPR Gene Dependency	1.0	3.27439
496100343_TCx_possible Alzheimer's disease_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.35926
WIPI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33324
CRCGN014_HEPG2_24H:I18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.84545
BRD-K33461572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25968
BRD-K47164766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38139
BRD-K25177502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20858
HC-24-QF06_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263076
COLO824	DepMap CRISPR Gene Dependency	1.0	3.49395
HT144	DepMap CRISPR Gene Dependency	1.0	4.90241
CRCGN015_MCF10A.WT.HP_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05258
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8568
EFHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11666
BRD-K72773309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06568
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1964
VB-89-RG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349824
GSE200352_5_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
9683_UTP18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.542297
KB-77-BA46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203738
SMSCTR	DepMap CRISPR Gene Dependency	1.0	4.95318
BRD-K66939340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07541
BRD-K40804250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55984
BRD-K20437312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52286
Processing of SMDT1	Reactome Pathways 2024	1.0	null
SLC25A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02223
CRCGN017_MCF10A.TP53.M_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16755
AC-36-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249188
OTX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6775
ALG11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0804
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.2693
BRD-K97421379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61242
BRD-K08247496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08791
Organellar ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.154
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K90762344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11219
GSE95685_2_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
YSCCC	DepMap CRISPR Gene Dependency	1.0	4.6045
BRD-K16686330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65305
BRD-K19573822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04222
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.4578
GTEx Heart 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-8.87943
LE-80-BM08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230174
BRD-K66559139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01273
BRD-K44426506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18788
BRD-K67478255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03774
BRD-K53274037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38889
BRD-K85311003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.087
BRD-K50278697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37914
CRCGN014_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.65084
Paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.388
BRD-K10704442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31056
CCT6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03056
BRD-K61027868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04715
BRD-K48188521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45869
GSE112762,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BORA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18876
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Atrial fibrillation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.985
POT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10205
GSE144231_3_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A95480808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1739
L33	DepMap CRISPR Gene Dependency	1.0	3.69232
BRD-A39407481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27703
BRD-K67014046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.58732
2925_FAM50A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.524187
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.78168
WDR36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8381
CCZ1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08398
BRD-K51017127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26874
BRD-K93148720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0433
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.03261
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306221
Urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
C99	DepMap CRISPR Gene Dependency	1.0	2.12957
BRD-K35058762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56299
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3146_FOXB2_ENST00000376708.1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.612005
CRCGN009_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.90014
BRD-K07861364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49625
ZBTB32	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00611929
import into the mitochondrion	GO Biological Process Annotations 2025	1.0	null
NB-80-IM48_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247523
BRD-K41517267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45035
PRPSAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3128
BRD-K06431647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30781
BRD-K13551202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79371
LLGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0237
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.900013
BRD-K57343972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47191
CRCGN008_HEPG2_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6593
BRD-K45112293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01302
BRD-K61416283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14362
GSE208350_4_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K54351451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21548
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.8681
CRCGN015_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2616
BRD-K89333198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25675
CRCGN012_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0848
GSE229914_2_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A06149038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06693
GSE226285_3_v_1_nr0b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
U2904	DepMap CRISPR Gene Dependency	1.0	3.58889
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.15
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4889
BRD-K02484256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44336
CD-47-YL43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246493
BRD-K68314790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14734
B-lymphoblastoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.072
ACTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00531
RNF182	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03483
protein insertion into membrane from inner side	GO Biological Process Annotations 2025	1.0	null
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AA-39-ZQ15_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237254
GSE210476_2_v_7_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.385733
BRD-K17753765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33638
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229485
WD-62-UB45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.430461
Nateglinide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
BRD-K67666705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50575
BRD-K91399333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.47889