association	dataset	threshold value	standardized value
GSE174498,GSE174500_3_v_4_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184284
KPNYN	DepMap CRISPR Gene Dependency	1.0	2.43509
A549_AMG-900_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192146
OCUM1	DepMap CRISPR Gene Dependency	1.0	5.82525
JHUEM7	DepMap CRISPR Gene Dependency	1.0	7.15907
GSE199255,GSE199356_4_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5303304-13073_2017_407_MOESM3_ESM.xlsx-mycn-sy5y-se_single_24DMSO_vs_2-Table_S2_Genes_differentially_expressed_by_24h_RA_treatment_DE_comparison_with_SY5Y-MYCN_control_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
Plasma membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.568
Chromocenter	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.806
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126463_4_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178340_1_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE134214_0_v_1_ell2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152354
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	271.156
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95685_2_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12178829-mmc4.xlsx-Sheet_3-MEG3-KD_Down-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HES7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.1425
GSE167373_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150072,GSE169209_6_v_9_qser1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153189_2_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9444
GSE150895,GSE150896_0_v_1_kif15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133691_1_v_3_lgr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.604
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	155.364
A549_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137139
A549_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150536
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE218060_7_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE209582_1_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE173201_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NOS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01215
A549_Tozasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170319
Nonsyndromic congenital nail disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Sodium Phenylbutyrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0248939
GSE178340_5_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.4406
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211126_1_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ARPC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12198
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
ZBTB33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21287
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE192513,GSE192515_1_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.394
GSE160373_8_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LRP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3412
COA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01365
GSE163297_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH1573	DepMap CRISPR Gene Dependency	1.0	3.04013
MCF7_A-366_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140129
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6603
A549_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173478
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SUM-149PT cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.077
PMC7870953-41540_2021_169_MOESM9_ESM.xlsx-KLF5_targets-target_gene_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
TOMM20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32689
KYM1	DepMap CRISPR Gene Dependency	1.0	2.14003
OTUD6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36086
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE218060_1_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NB1	DepMap CRISPR Gene Dependency	1.0	6.86035
GSE216043_10_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HMCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24649
GSE215351,GSE215794_1_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE60837_0_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178340_1_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179806
GSE234340_12_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE134375_0_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214248_0_v_1_cxcl8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
A549_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138335
GSE230744,GSE237803_0_v_3_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95077_1_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE138741,GSE138743_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235881
A549_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150365
GCM2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8758
GSE152441,GSE152442_0_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134162
A549_Tazemetostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0111895
Uterus	GTEx Tissue Gene Expression Profiles 2023	1.0	2.6693
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180185_4_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229973_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Flavopiridol HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175632
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE129389_0_v_4_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
Swr1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.908
A549_ZM 447439_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152455
T-00127_HEV1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.4
GSE145915_5_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.639
FLNC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18046
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AR-35413990-HUMAN-ARPOSCRPROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
A549_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0107825
CHD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0589
PMC12187926-41421_2025_809_MOESM8_ESM.xlsx-w_SRPK2-KD-mouse_kinase_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	132.625
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
GSE48812_2_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152734,GSE152735_1_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173201_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PEA1	DepMap CRISPR Gene Dependency	1.0	2.23633
Prostate carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.191
protein autophosphorylation	GO Biological Process Annotations 2025	1.0	null
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_0_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217405_0_v_1_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0290175
A549_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173232
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.636
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147876,GSE147877_2_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158502,GSE158506_3_v_0_fat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015829
GSE179036_1_v_0_trim24_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE129725_1_v_5_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PRDM9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	345.198
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Petiole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.281
GSE216043_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FAM110D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24082
GSE77108_3_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
QSOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2655
HCC1419	DepMap CRISPR Gene Dependency	1.0	3.47263
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
POGZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02142
PNISR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73249
MCF7_SRT3025 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177293
Tiplaxtinin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.25
GSE221577_3_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_PD173074_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124871
PMC12337651-mmc1.pdf-15-ZBED6_ZBED6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158815_5_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_BMS-754807_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208716
GSE68156_0_v_1_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Selisistat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135163
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.565
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE185519_1_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE145639_7_v_4_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
Histamine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
GSE180185_9_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151612_4_v_11_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.439
Cestode	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.714
NBPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53211
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
GSE169152_3_v_1_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.392
NPPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36802
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110580_1_v_0_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Thyroid gland disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.439
Ouabain (Octahydrate)_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0156688
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.357
GSE116354,GSE117379_2_v_4_cox2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JUN kinase kinase kinase activity	GO Molecular Function Annotations 2025	1.0	null
A549_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133418
KANSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37403
G6PD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13217
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE129811_5_v_0_niacin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Keratin filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.697
GSE135030_11_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5294
MCF7_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156284
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
protein modification process	GO Biological Process Annotations 2025	1.0	null
PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE172458_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE229973_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE190316,GSE190324_1_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
phosphorylation	GO Biological Process Annotations 2025	1.0	null
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195559_2_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130396_7_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
Nucleosome disassembly/reassembly complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.838
GSE153189_1_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Rucaparib_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015212
UNC45A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40843
GSE210870_0_v_2_snai1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE102132_2_v_1_irf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
REPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18816
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184902_3_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1278
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VIRMA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09925
GSE125014_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF485	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1888
A549_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158903
A549_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146183
A549_Tucidinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014862
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE113106_0_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3,5-Dichlorosalicylic acid	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
JUN kinase kinase kinase activity	GO Molecular Function Annotations 2023	1.0	null
GSE151612_0_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF528	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74946
GSE149000_2_v_0_cyp3a5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nr1h2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3965
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE231648_0_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195393
A549_Hesperadin_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0103958
ZNF530	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	81.7712
GSE102269_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6870463-Table_7.xlsx-Family_H_No_LPS-Untreated_BMDMs_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE96649_1_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242083,GSE242098_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE87617_1_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE181517_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PAX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08328
GSE201217_3_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
VPS26A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35397
GSE94849_1_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146074_1_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144912
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.1
Cells - Cultured fibroblasts	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.674799
GSE172189_0_v_1_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213650_3_v_2_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.4467
PMC5848610-supp_gr.228809.117_Supplemental_Table_S4.xlsx-Table_S4D-Supplemental_Table_S4D_List_of_differentially_expressed_genes_upon_siZFX_with_promoters_bound_by_ZFX_in_C42B_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135030_11_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Bosutinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022212
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.648
GSE249098_3_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
A549_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132978
GSK3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25115
GSE169356_2_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NR1H2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28432
OVMIU	DepMap CRISPR Gene Dependency	1.0	3.55429
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8407
GSE178340_1_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE197555_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5075
PMC10534007-Table_2.xlsx-S3_unique_up_MSC_V-817_elements_included_exclusively_in_VM-CUB1_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
C75	DepMap CRISPR Gene Dependency	1.0	3.53654
GSE78199_2_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYH9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30811
GSE121319_1_v_0_gprc5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.4231
PMC10769314-NIHMS1954782-supplement-9.xlsx-Table_S7B-Table_S7B_Frontal_cortex_relative_gene_expression_from_post-KD_and_pre-KD_recipient_mice_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200839,GSE233826_5_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE62843,GSE64370_0_v_1_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RCC10RGB	DepMap CRISPR Gene Dependency	1.0	2.42755
GSE193258,GSE193259_9_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Mocetinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0104388
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_JQ1_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177732
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE116299_4_v_3_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140143
INTS13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11397
GSE102675_2_v_1_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_2-1769_genes_are_more_than_four-fold_upregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
MAPK signaling pathway	KEGG Pathways 2026	1.0	null
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Trametinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116612
A549_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153403
GSE138863_2_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
CERS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36895
MAST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14088
NTF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27287
GSE123943_4_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
GSE178340_5_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12499388-ADVS-12-e01774-s002.xlsx-Table_S1-Table_S1_Differentially_Expressed_Genes_between_wild-type_and_TET3-knockout_PANC-1_cells_TET3	Rummagene Transcription Factor Associations 2026	1.0	null
Nonsyndromic congenital nail disorder 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.328
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018648
A549_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139726
GSE135705_5_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
GSE182179_5_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141783
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.1065
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239844_8_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Lapatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233008
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147876,GSE147877_2_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MM160113	DepMap CRISPR Gene Dependency	1.0	2.48326
Mesenchymal glioma stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.382
GSE149035_1_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146074_9_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.2265
GSE148657_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.439
MOLM13	DepMap CRISPR Gene Dependency	1.0	2.01902
A549_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151655
HT1376	DepMap CRISPR Gene Dependency	1.0	3.89476
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149858
Alzheimer disease and age of onset	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.61549
A549_Ofloxacin_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202299
GSE248858_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195927
GSE94849_1_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE130396_7_v_6_braf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147626_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Treprostinil	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
Male reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.191
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE117212,GSE117214_0_v_1_zbtb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sapropterin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
GSE123943_2_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CERS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24057
697	DepMap CRISPR Gene Dependency	1.0	9.80318
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE108084_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153189_2_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125014_1_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SW982	DepMap CRISPR Gene Dependency	1.0	3.28274
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE181517_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.731
PABPC1L2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41605
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	56.9741
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
COLO320	DepMap CRISPR Gene Dependency	1.0	2.27694
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.482717
PMC12375500-41388_2025_3449_MOESM1_ESM.xlsx-DBP_down-gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164463_2_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_PD98059_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0255589
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146546,GSE146807_0_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_8_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE133087_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_MLN8054_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164311
A549_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174064
GSE146074_1_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152441,GSE152442_6_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_UNC1999_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158646
GSE68156_3_v_4_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.513
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95685_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213650_3_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE144484_0_v_1_mllt6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Vegetative stage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.624
GSE211128_7_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118816_0_v_1_myo1c_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175787_13_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147664_0_v_1_arid1b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE224970,GSE224971_1_v_0_sap30_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149359_3_v_1_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_PCI-34051_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123604
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_9_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
protein phosphorylation	GO Biological Process Annotations 2025	1.0	null
CNPY3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16879
GSE239844_6_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165548_2_v_7_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7789
GSE135030_8_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.65
GSE167474_1_v_3_naa40_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12187926-41421_2025_809_MOESM8_ESM.xlsx-x_LPS-BMDCs-mouse_kinase_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.6365
A549_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172128
GSE108495_1_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127335
PMC12629863-CAC2-45-1547-s002.xlsx-Supplementary_Table_S10-Supplementary_Table_S10_Kinases_predicted_to_phosphorylat_YY1_at_Ser247_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Alisertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131867
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_SYMBOL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200839,GSE233826_2_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0248016
A549_Ellagic acid_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175124
LYAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11373
GSE169617_1_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.263
A549_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126507
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102675_3_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174701_1_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6902611-40104_2019_400_MOESM2_ESM.ods-FA-SNA-Total_of_1_054_out_of_1_627_proteins_were_considered_for_analyses_65_SNAI1	Rummagene Transcription Factor Associations 2026	1.0	null
Ebf2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.8202
GSE154074_2_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11161988-12906_2024_4523_MOESM3_ESM.pdf-116-ESX1_ESX1	Rummagene Transcription Factor Associations 2026	1.0	null
CNFN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04028
GSE180951_2_v_3_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158633
PMC12211054-spectrum.00100-25-s0002.pdf-13-ZNF595_ZNF595	Rummagene Transcription Factor Associations 2026	1.0	null
PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.202
MCF7_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148725
ADA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58669
WASHC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14708
GSE230174_0_v_1_dagla_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133213_6_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE63048_11_v_12_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226249_2_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.191
A549_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155027
ZNF98	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68161
GSE239688_4_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE165334_3_v_1_dabrafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146612_1_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CFAP97	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46114
GSE88819_5_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139016_3_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00967749
GSE240386,GSE242143_1_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168563
GSE245778_1_v_0_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157911_1_v_0_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_JNJ-7706621_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018109
MAP kinase kinase kinase activity	GO Molecular Function Annotations 2025	1.0	null
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.185
GSE96777,GSE96778_1_v_0_zbtb4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124608
PSMC3IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67739
GSE157555,GSE157556_5_v_6_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08974
A549_Alendronate sodium trihydrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149868
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_JK_LPS-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151612_0_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
DDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08605
GSE174586_0_v_1_slc4a11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NAXD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08785
PRRC2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35368
HYCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12236
MCF7_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139601
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A-2058 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.933
GSE205070_1_v_4_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE261177_0_v_1_tnfrsf12a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152748
GSE231648_1_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
chr1_233379188_G_A_b38	GTEx eQTL 2025	1.0	1.12752
Thyroid gland carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.439
GSE120612_7_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSTP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12227
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SOSS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.606
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12187926-41421_2025_809_MOESM8_ESM.xlsx-w_SRPK2-KD-kinase_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Thorax	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
COL7A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08649
protein homodimerization activity	GO Molecular Function Annotations 2023	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
XRN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65552
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2077
SMAD3-30307970-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
Rarg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	58.1924
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7806
GSE68925_1_v_0_fasudil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE121319_1_v_2_gprc5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216238,GSE216241_0_v_1_tonsl_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.5
GSE213588_9_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Glioma stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.706
A549_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153724
CTV1DM	DepMap CRISPR Gene Dependency	1.0	2.11899
GSE102269_3_v_0_clpp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE264010_0_v_1_parp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WDR46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10616
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Hesperadin_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150343
CD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19025
GSE165647_6_v_7_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.597586
GSE100528_1_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_1_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_UNC0631_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185579
SRSF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19791
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_BMS-911543_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159804
VDR-33458620-PRIMARYEPITHELIAL-HUMAN-PROSTATE	ChEA Transcription Factor Targets 2022	1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
UBE2H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01075
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175944
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Tubastatin A HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146996
GSE216273,GSE216292_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182179_0_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.9534
MSH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07043
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D4_vs_D9-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
protein autophosphorylation	GO Biological Process Annotations 2023	1.0	null
SUIT2	DepMap CRISPR Gene Dependency	1.0	2.00697
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164505,GSE164506_3_v_2_indisulam_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151798
A549_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144615
GSE172016_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126463_4_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mitochondrion-derived vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.806
A549_AT9283_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145278
GSE147876,GSE147877_2_v_9_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Visceral endoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.642
GSE147893,GSE147897_2_v_1_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Triamcinolone Acetonide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152687
GSE169155_6_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221577_2_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF701	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	89.956
E2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	98.757
A549_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017394
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.439
GSE171837_0_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161662
GSE216043_11_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
phosphorylation	GO Biological Process Annotations 2023	1.0	null
GSE147876,GSE147877_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130434
Male reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.191
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE167474_2_v_3_naa40_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158197_2_v_10_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_ITSA-1_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016857
GSE231829_0_v_1_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11330984-41467_2024_51229_MOESM6_ESM.xlsx-MYC_UP-ID_ENSEMBL_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195568_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154299
GSE205070_2_v_9_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE220520_1_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF124	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75582
KPNYS	DepMap CRISPR Gene Dependency	1.0	4.68162
OVCA420	DepMap CRISPR Gene Dependency	1.0	2.01989
A549_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210048
GSE175883_0_v_1_dis3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
GSE217452_2_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
COPS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0358
GSE126463_6_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131377_1_v_0_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174637
GSE197555_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23594
GSE156923_2_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Danusertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136851
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205070_1_v_6_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
A549_TG101209_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182873
PMC12358249-supplementary_table_s5_ioaf064.xlsx-DMRT1_-_vs_WT__4_months-Unnamed_1_DMRT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243021
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
DVL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5981
GSE189609_1_v_0_hax1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_1_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Dasatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207515
Colorectal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
VCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46954
PK-8 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.918
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210911_1_v_0_crem_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE175787_11_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_KW-2449_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016171
GSE121866_0_v_3_six4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Alisertib_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179585
GSE143499_0_v_1_gata6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242083,GSE242098_3_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142430_3_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.58
A549_SRT3025 HCl_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142702
GSE216043_11_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CGB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18331
22RV1	DepMap CRISPR Gene Dependency	1.0	2.70167
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	171.093
GSE182770,GSE182784_0_v_1_chd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.7049
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE173810_4_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149359_2_v_1_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.191
A549_Tucidinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194079
A549_Belinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124588
PMC6928094-395_2019_765_MOESM7_ESM.xls-DEGs_AR7_vs_Pre-patterned-List_of_differentially_expressed_genes_in_AR7_vs_Pre-patterned_cells_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182179_0_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MDA-MB-436 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.529
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8367
GSE115395_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180525,GSE180528_1_v_3_tbx3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PSMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10486
GSE206516,GSE206518_3_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114883_0_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.8768
GSE189609_1_v_2_hax1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SPARC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34307
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205070_2_v_5_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_JNJ-26854165_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243773
GSE169590_0_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229973_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAP3K21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85278
WM1799	DepMap CRISPR Gene Dependency	1.0	4.16909
PF-543	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.53
GSE181003_3_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	150.268
rpmi1788	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.812
A549_Decitabine_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0107573
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EFE184	DepMap CRISPR Gene Dependency	1.0	2.78387
GSE89057_0_v_1_sox5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140937,GSE140938_1_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9882185-media-4.xlsx-Neuron_KD-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169590_6_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nasopharyngeal carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.994
A549_MLN8054_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135733
GSE192870_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE93674_2_v_3_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174498,GSE174500_3_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DHX36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03712
GSE184902_3_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_4_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130712
A549_Patupilone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134094
VPS35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07798
GSE175787_11_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE105169,GSE105175_0_v_1_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_8_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE221577_1_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain - Hypothalamus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.653179
Rosette leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.849
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.2618
GSE159049_3_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154074_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219948
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain stem	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7566
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_AICAR_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127135
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158132
GSE101336_1_v_0_decitabine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.609
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
SP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	248.284
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.625
Hindbrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CAL-51 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.723
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.439
GSE70499_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
A549_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156292
PYGO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06649
GSE140936,GSE140938_2_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165057
A549_Barasertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145946
GSE135030_3_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Paraflagellar rod	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.887
GSE152441,GSE152442_1_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169152_5_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE110248_1_v_6_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211262,GSE211263_2_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139455_0_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171352_2_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE206729_3_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178714_3_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Rarb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	50.2263
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_2_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5969
GSE80098,GSE80366_0_v_8_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.847
Cell periphery	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.568
PMC4269325-NIHMS634665-supplement-supp_table4.xls-H3K27me3_TRIM37_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148692,GSE148695_7_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PATZ1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	390.46
GSE216043_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174701_1_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Testis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.639281
GSE211128_9_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_EED226_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140406
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149880_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1979
A549_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197375
ES5	DepMap CRISPR Gene Dependency	1.0	4.63388
KNS42	DepMap CRISPR Gene Dependency	1.0	2.56857
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HCT-15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.05
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Alendronate sodium trihydrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120041
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8438
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01532
A549_Meprednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171394
GSE183327,GSE183328_1_v_0_ddit3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5848610-supp_gr.228809.117_Supplemental_Table_S3.xlsx-Table_S3F-Supplemental_Table_S3F_ZFX_binding_pattern_clustering_information_for_genes_with_promoters_bound_by_ZFX_related_to_Figure_2I_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0768
GSE131649_6_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE203072_2_v_3_rpl3l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203017_0_v_1_irs2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180221
GSE185519_1_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_1_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
GSE161864,GSE161866_1_v_3_ror2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205070_1_v_9_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193900,GSE193905_1_v_0_pura_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_UNC0631_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182969
GSE121824,GSE121826_0_v_8_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_PHA-680632_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018551
TPRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03417
GSE228106_0_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205070_2_v_7_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.647
A549_Cerdulatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00956468
GSE155031_6_v_1_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE251992_1_v_0_saracatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE230174_0_v_1_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Exoneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.815
A549_Lomustine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202962
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0214318
GSE155031_5_v_1_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128474
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPL36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02194
GSE216043_7_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE206516,GSE206518_5_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE230744,GSE237803_5_v_3_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217405_3_v_2_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
protein modification process	GO Biological Process Annotations 2023	1.0	null
A549_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162293
Reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.191
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.491
PMC12187926-41421_2025_809_MOESM8_ESM.xlsx-x_LPS-BMDCs-kinase_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
T3	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
A549_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0104252
A549_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168893
A549_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133272
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114883_1_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226249_0_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168274
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HCFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68047
SDHAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74694
COLO679	DepMap CRISPR Gene Dependency	1.0	2.14144
GSE213588_9_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE105170,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE93156_1_v_0_idelalisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182179_0_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.263
ML-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.586
KLF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	152.297
A549_PHA-680632_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01855
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
A549_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202803
HCC78	DepMap CRISPR Gene Dependency	1.0	2.36178
GSE150669_0_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184987
GSE211983_0_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.426
HLA-DRB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15307
GSE193258,GSE193259_9_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134232
GSE231648_4_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154074_5_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205163,GSE205164_9_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1d-List_of_2302_of_genes_differentially_regulated_by_SOX2_FDR_0_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE153189_1_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Azacitidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159132
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1935
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153867_6_v_4_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	201.409
CDC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06286
GSE178340_1_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Crizotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018054
TMEM140	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53078
GSE168587,GSE168752_3_v_1_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171177,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10591418-12711_2023_849_MOESM11_ESM.xls-AA_5W_vs_LS_5W-gene_name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE107505_3_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157684,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	1.0	null
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279202
ZNF830	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07425
GSE178340_7_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
LAN2	DepMap CRISPR Gene Dependency	1.0	3.95091
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE63048_11_v_5_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156337
GSE202434,GSE202438_15_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97815
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Nilotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168463
PROSER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03451
A549_Tozasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163946
GSE87412,GSE92423_3_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PLAG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	199.833
GSE76425_0_v_7_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174385
MRPL46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29236
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.149
MPT synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.514
PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.439
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
Cerebellum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152441,GSE152442_0_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.2497
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178340_7_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE125014_6_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_7_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
UMUC16	DepMap CRISPR Gene Dependency	1.0	2.40464
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H2BC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10564
GSE178714_3_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE206516,GSE206518_6_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199606_3_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.352
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HCC70	DepMap CRISPR Gene Dependency	1.0	4.24326
Pt-K1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.877
PMC11003700-pbio.3002240.s013.xlsx-siMYCN_RNA_IMR32_48h_q_0_05_1_5-Table_S6_Genes_commonly_and_differentially_regulated_by_MYCN_and_WDR5_in_IMR32_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
protein homodimerization activity	GO Molecular Function Annotations 2025	1.0	null
ALYREF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18835
CCK81	DepMap CRISPR Gene Dependency	1.0	7.65788
GSE161864,GSE161866_0_v_2_ror2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174498,GSE174500_5_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.4202
GSE126463_1_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE212486,GSE212488_0_v_1_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE168596_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	224.992
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142684_3_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217405_0_v_1_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCNE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04909
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_1_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.638
NH12	DepMap CRISPR Gene Dependency	1.0	2.41372
GSE221577_3_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9376070-41419_2022_5157_MOESM18_ESM.xlsx-Sheet1-Table_S4_Differentially_expressed_genes_of_HNRNPC-KD_and_NC_cells_identified_in_the_RNA-seq_analysis_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193351_1_v_3_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_4_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.191
MCF7_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014983
GSE175787_13_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_AZ 960_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166356
A549_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224537
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.25
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
protein phosphorylation	GO Biological Process Annotations 2023	1.0	null
GSE202434,GSE202438_7_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135514_2_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE159049_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152432_5_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LoVo cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.995
GSE216043_10_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE185519_1_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206066
NHEM cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.755
A549_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184238
GSE135514_8_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161805
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95077_5_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.603763
GSE120612_4_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7360734-41467_2020_17206_MOESM9_ESM.xlsx-OCI-AML3-Unnamed_0_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
RNA polymerase IV complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.655
GSE153189_1_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150178
GSE149355_0_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149901_3_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_JQ1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180557
ARHGDIG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34907
SS18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49732
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210682_2_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_4_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.581
A549_PHA-680632_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137227
chr1_233331872_G_A_b38	GTEx eQTL 2025	1.0	6.74529
Membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.568
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.6172
GSE248769_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE163240_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.601
GSE146612_1_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147626_2_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_11_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AT7519_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00634017
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	303.08
GSE196671_6_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
GSE148695,GSE167281_0_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FCHO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30652
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TRKC	Kinase Library Tyrosine Kinome Atlas	1.0	96.5
A549_TG101209_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185425
GSE218060_5_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE95077_1_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
DCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.84371
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211128_2_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178714_1_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ebf4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.8485
PMC9618568-41467_2022_34255_MOESM5_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_UNC1999_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189996
GSE76425_0_v_10_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE96777,GSE96778_3_v_2_zbtb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.16
GSE174498,GSE174500_5_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE68156_0_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Thyroid cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.439
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KCNMB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03771
insulin-responsive compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.357
ZNF688	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2177
SCN4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00189
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120612_4_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232292
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
GSE190316,GSE190324_1_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CACTIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13231
GSE217405_3_v_2_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3988
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0235039
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224768
GSE216757_4_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120612_6_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Bisindolylmaleimide IX_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130682
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HT-115 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.828
GSE152441,GSE152442_0_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endocrine system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.439
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198069
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	270.945
IM-95 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.473
GSE158834_1_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9218734-Supplementary_Data3.xlsx-KRIEG-KRIEG_HYPOXIA_NOT_VIA_KDM3A_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
VLDLR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29826
GSE130246_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	183.182
chr1_233391752_T_C_b38	GTEx eQTL 2025	1.0	1.3284
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE207582_2_v_1_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152432_9_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216538_1_v_6_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
Neurilemoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.935
Nerve - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.656268
DDX27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32103
GSE240645_3_v_2_u90926_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229468,GSE229471_0_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	226.754
GSE229973_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.188
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210101,GSE210114_2_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KIAA1143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60224
A549_Bisindolylmaleimide IX_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150273
GSE216043_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239844_1_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAP kinase kinase kinase activity	GO Molecular Function Annotations 2023	1.0	null
SUM cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.823
A549_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147638
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9544
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
HKBMM	DepMap CRISPR Gene Dependency	1.0	10.2539
BE2M17	DepMap CRISPR Gene Dependency	1.0	9.44807
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Alisertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192135
GSE72895,GSE72896_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.259
PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
POLH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18053
ZNF236	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24345
PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_TAZ-CAMTA1_vs_EV-Gene_CAMTA1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221577_1_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE141143_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178340_7_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158197_0_v_11_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0288133
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	62.5802
GSE202434,GSE202438_10_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Alisertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0233076
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176228
GSE206516,GSE206518_0_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NSC43673	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172244
TAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08334
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	1.0	1.49025
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE232631_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217776,GSE217829_4_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161864,GSE161866_4_v_3_ror2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE163862_1_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Baricitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207637
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.0856
Te	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.694
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	1.0	3.87768
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.8231
Yy1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.1857
GSE166184,GSE166185_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DNA replication factor C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.622
A549_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157605
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152842
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	86.2792
NCIH2110	DepMap CRISPR Gene Dependency	1.0	4.53055
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	43.0751
GSE238018_1_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248858_1_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ENDOU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00823
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1071
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.5653
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.03383
GSE118816_2_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185503
GSE192362_1_v_0_erastin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE232564,GSE232566_0_v_2_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
GSE95077_5_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7064337-elife-51373-supp1.xlsx-MTF2_targets_shCTR-List_of_2011_genes_marked_by_MTF2_ChIPseq_in_control_conditions_shCTR_MTF2	Rummagene Transcription Factor Associations 2026	1.0	null
MED7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21627
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
TTC642	DepMap CRISPR Gene Dependency	1.0	2.77894
PMC9894241-pnas.2211429119.sd05.xlsx-G2_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
IFI6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28089
RAG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79851
GSE224877_2_v_1_pctp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1227
GSE143743_0_v_2_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF320	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	361.143
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.395
GSE175787_11_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Connective tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE211286_7_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Tacedinaline_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186887
A549_Aurora A Inhibitor I_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131195
Endocrine gland cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.439
GSE221020,GSE221023_2_v_1_pten_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
CDC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0155
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146074_0_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
UNC13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41948
GSE242083,GSE242098_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142794
A-317491	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
GSE138001_2_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.5862
GSE152441,GSE152442_7_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190613
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.5185
GSE169152_3_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114883_0_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_4_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147876,GSE147877_4_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE145639_7_v_2_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157555,GSE157556_5_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174751_0_v_1_postn_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHMP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54005
GSE180185_9_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.439
GSE200839,GSE233826_3_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE150669_0_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE219195_4_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214038
NB10	DepMap CRISPR Gene Dependency	1.0	6.46169
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_4_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF112	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6619
GSE210870_0_v_1_snai1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180525,GSE180528_2_v_0_tbx3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165548_2_v_1_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150766
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.439
GSE139427_2_v_1_ibrutinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0242442
Metencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE157904_3_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.6413
RARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59757
GSE178340_5_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ITGB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02639
GSE95077_1_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Cimetidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184301
GSE221020,GSE221023_2_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157296,GSE157298_4_v_2_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12542189-13148_2025_1982_MOESM2_ESM.pdf-7-KLF2_KLF2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE238116_1_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130396_1_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE246195,GSE246305_2_v_5_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Roxadustat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162709
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_MC1568_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020361