association	dataset	threshold value	standardized value
CJUN-26792858-CHIP-SEQ-BT549-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
S-Adenosyl-L-methionine (disulfate tosylate)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0292694
12917485-Table8	GeneSigDB Published Gene Signatures	1.0	null
decreased susceptibility to pharmacologically induced seizures	MGI Mouse Phenotype Associations 2023	1.0	null
arrestin2	GeneRIF Biological Term Annotations	1.0	null
regulation of primary metabolic process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-3937	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
activation of protein kinase activity	GO Biological Process Annotations 2015	1.0	null
mania	GWASdb SNP-Phenotype Associations	1.0	0.85593
RARB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25133
medial mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33759
KOPN8	CCLE Cell Line Gene CNV Profiles	1.0	2.27763
cetirizine-4231	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAPK1	Pathway Commons Protein-Protein Interactions	1.0	null
Clopidogrel_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0202127
superficial stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09335
abnormal nervous system physiology	MPO Gene-Phenotype Associations	1.0	null
CDKN2C	Pathway Commons Protein-Protein Interactions	1.0	null
Embryo Loss	CTD Gene-Disease Associations	1.0	1.04465
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.8665
primary auditory cortex (core)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24924
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.01502
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.7127
PANC 05.04	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.837363
MCF7_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119438
BRD-K73494324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58325
MCF7_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143561
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.6416
lower respiratory tract disease	GWASdb SNP-Disease Associations	1.0	0.466495
PMC9895410-Table_1.xlsx-Neuroendocrine_regulation_genes-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
P300-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_11361_KD_METTL3_SRP292229	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.36805
BRD-K90284572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96038
Perturb_7914_KD_TOP1MT_SRP372079	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.39455
Perturb_10182_KD_RAD21_SRP225887	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.3816
Orbital area, medial part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17757
hsa-miR-29b	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
hsa-miR-451b	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
BRD-K56125296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0062
Lateral reticular nucleus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58822
neuronal	Phosphosite Textmining Biological Term Annotations	1.0	null
PMC4459818-emmm0007-0788-sd2.xls-Table_S3-Table_S3_Correlation_of_AR_and_UPR_gene_expression_in_the_MSKCC_prostate_cancer_cohort_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K78196882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31122
Wnt Signaling Pathway and Pluripotency(Mus musculus)	WikiPathways Pathways 2014	1.0	null
Alcoholic liver disease	KEGG Pathways 2026	1.0	null
MyD88 cascade initiated on plasma membrane	Reactome Pathways 2024	1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07938
SP in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09256
BRD-K28982281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08919
Postsubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.79123
Hyperplasia	CTD Gene-Disease Associations	1.0	1.69909
CDKN2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13545
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62844
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.16766
BRD-K92655427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97399
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_4_FDC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
sulfathiazole-1963	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
differentiation	Phosphosite Textmining Biological Term Annotations	1.0	null
RXF393	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.842727
Irinotecan_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0345883
GSE101537_4_v_2_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
potentially	GeneRIF Biological Term Annotations	1.0	null
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74423
wt1_17420277_e11dot5_urogenital_ridge_lof_mouse_gpl1524_gds2747	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.007272
BRD-K88658905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63866
GSE142232,GSE142234_0_v_2_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
methoxamine-2848	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-A456-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K88274759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57321
mantle zone of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42436
Oxidative damage response	WikiPathways Pathways 2024	1.0	null
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-3185	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
GTEX-RVPV-0011-R3A-SM-2TF63	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20469
Toll Like Receptor 2 (TLR2) Cascade	Reactome Pathways 2014	1.0	null
JNK-IN-8	DGIdb Drug Targets 2026	1.0	0.339308
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940548
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7183
Interanteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5677
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A8HX-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K29418729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47111
MBTPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54293
GTEX-NL4W-0011-R8a-SM-2I3G4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903958
BRD-K92981306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1107
BRD-K84241565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17955
arrestin3	GeneRIF Biological Term Annotations	1.0	null
EX229_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0481206
BRD-K17718789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.85108
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9404
Coronary Artery Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
TRIM45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13075
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.45035
PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Ischemia	CTD Gene-Disease Associations	1.0	1.39086
positive regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
Perturb_11698_KO_METTL3_SRP287496	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.92744
Perturb_10199_KD_RUNX1/RUNX1T1_SRP291095	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.08821
EW16	DepMap CRISPR Gene Dependency	1.0	2.37805
Prion disease	KEGG Pathways 2026	1.0	null
Primary visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.02811
GSE229973_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAP kinase kinase activity	GO Molecular Function Annotations 2025	1.0	null
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-ATF3_TGAYRTCA_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XMD1-0011-R9A-SM-4AT49	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838975
Heart Diseases	CTD Gene-Disease Associations	1.0	2.10597
BRD-K85633971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06222
HIV Infections	HuGE Navigator Gene-Phenotype Associations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A713-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K06399794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21773
phosphate-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57218
A549_Barasertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.00954218
PMC7793877__F5	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68558
hsa-miR-1273e	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
Perturb_11520_KD_PI4KB_SRP162839	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.36695
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
periventricular stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25538
CRCGN015_MCF10A.TP53.M_24H:O23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4835
BCL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19057
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27891
GSE126345_11_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JNK INHIBITOR IX	DGIdb Drug Targets 2026	1.0	0.508961
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DR-A0ZM-01A-12R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACTR8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02221
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A3MF-01A-12R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
WDR82	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07441
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6591
Perturb_13754_KD_KLF3_SRP233218	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.05914
Retinal Artery Occlusion	CTD Gene-Disease Associations	1.0	1.05052
H3K14ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K86946907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5572
CRCGN015_MCF10A_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66605
spiradoline-4375	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AZD-7648_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0308543
GTEX-PVOW-0011-R5A-SM-32PL7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917143
BRD-K75426080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40979
GSE211126_3_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MIOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00542
BRD-K93806272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01792
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05106
GA-43-FL03_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225647
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30625
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.90935
PMC7062835__F1	PFOCR Pathway Figure Associations 2023	1.0	null
MAPK targets/ Nuclear events mediated by MAP kinases	Reactome Pathways 2014	1.0	null
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MDAMB436	CCLE Cell Line Gene CNV Profiles	-1.0	-2.20265
adaptor-proteins-signal-transducing	Phosphosite Textmining Biological Term Annotations	1.0	null
Prestwick-691-4172	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859342
BRD-K46742113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14128
prednisone-1978	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Fc-epsilon receptor signaling pathway	GO Biological Process Annotations 2025	1.0	null
amygdala	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
axon	Phosphosite Textmining Biological Term Annotations	1.0	null
CC-44-MG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22239
B4GALNT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94054
L3HYPDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17058
Perturb_10001_KD_FMR1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.26679
Th17 cell differentiation	KEGG Pathways 2026	1.0	null
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
Perturb_14763_KD_LATS1/LATS2_SRP345234	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.71829
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-d-Classification_of_camel_SON_basal_genes_-_enzymes_SON	Rummagene Transcription Factor Associations 2026	1.0	null
FRS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50425
Bentamapimod_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0511513
primary motor cortex (area M1, area 4)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.53035
vincamine-2327	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
testicular cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.098505
SNU761	CCLE Cell Line Gene Expression Profiles	-1.0	-1.58125
RL	CCLE Cell Line Gene Expression Profiles	1.0	2.55281
BRD-A85231803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83133
INSULIN, REGULAR, HUMAN	DGIdb Drug Targets 2026	1.0	0.0391509
free	GeneRIF Biological Term Annotations	1.0	null
PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9	Rummagene Transcription Factor Associations 2026	1.0	null
layer 6b of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.19579
ARRB2	Hub Proteins Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MU-A5YI-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9064_KD_POU5F1_SRP100928	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.1827
GSE152432_9_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_CUDC-907_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0427155
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848723
BRD-K39794286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11032
GTEX-R55E-0011-R8A-SM-2TC66	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900252
Autism	DisGeNET Gene-Disease Associations	1.0	null
OB granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42239
Vomiting	CTD Gene-Disease Associations	1.0	1.38891
JHU022	DepMap CRISPR Gene Dependency	1.0	5.87479
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41535
BRD-K38446773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41711
Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-BrtoFay_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE159728,GSE159730_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K10820981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24006
SP in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.891891
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8176
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30615
Integrin-mediated Cell Adhesion(Mus musculus)	WikiPathways Pathways 2014	1.0	null
19192944-TableS4	GeneSigDB Published Gene Signatures	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81D-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87418665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42592
RALB	Pathway Commons Protein-Protein Interactions	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5KV-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC2825767__F1	PFOCR Pathway Figure Associations 2024	1.0	null
PMC12593019-ao5c06233_si_001.pdf-19-AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08993
leflunomide-2539	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_1118_KD_SENP6_SRP328207	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.77951
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9336
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.57186
P3HR1	CCLE Cell Line Gene Mutation Profiles	1.0	null
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.784087
dinoprost-2446	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_15110_KD_PPHLN1_SRP218207	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.48538
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_81_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47854067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.91396
BRD-K63813316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03893
CEBPB-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
L-540	GDSC Cell Line Gene Expression Profiles	-1.0	-1.94328
CREM	ChEA Transcription Factor Targets	1.0	null
Perturb_13949_KD_CDK4/CDK6_SRP258989	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.17349
17009876-tableS1a	GeneSigDB Published Gene Signatures	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.79428
PMC6113163__F4	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K88645787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49886
GTEX-PLZ6-1526-SM-2S1OC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27196
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.229716
BRD-K59317601_INK-128_HCC515_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
brain stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057324
cerebellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065204
urethral disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.412031
mantle zone of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03499
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Futibatinib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0381973
SUDHL6	CCLE Cell Line Gene Expression Profiles	1.0	1.71724
GTEX-WHSE-0011-R2A-SM-3P5ZL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979929
Prostate-hillock cell of prostate epithelium	Tabula Sapiens Gene-Cell Associations	1.0	1.11436
monensin-3704	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FUS-26573619-CHIP-SEQ-HEK293-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_8883_KD_CSL_SRP142324	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.8753
hsa-miR-3134	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_62_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02882
insulin signaling pathway	KEGG Pathways	1.0	null
PMC6192166__F3	PFOCR Pathway Figure Associations 2023	1.0	null
ischemia	Phosphosite Textmining Biological Term Annotations	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
almotriptan	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52175
BICR18	CCLE Cell Line Gene Mutation Profiles	1.0	null
MCF7_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199043
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JJ-11A-12R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Generalized Tonic Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
PMC4262241__F3	PFOCR Pathway Figure Associations 2023	1.0	null
PMC7940873__F7	PFOCR Pathway Figure Associations 2023	1.0	null
N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide	DrugBank Drug Targets	1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SCC9	DepMap CRISPR Gene Dependency	1.0	7.56155
Ascites	CTD Gene-Disease Associations	1.0	1.1617
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66589
intellectual disability	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
CRCGN013_HEPG2_24H:I14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16667
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20088
TM31	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68164
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hematopoietic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.127518
polymorphonuclear neutrophil	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.23673
regulation of macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
anteroventral periventricular preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13532
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899673
IGR37	CCLE Cell Line Gene CNV Profiles	-1.0	-1.87534
PMC8410861-41467_2021_25544_MOESM32_ESM.xlsx-MCR-MCR_cells_-_DGE_iGCA_testis_vs_adult_testis_from_GSE112013_and_GSE124263_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K94518115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77544
BRD-K55104181	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36226
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.07303
comparably	GeneRIF Biological Term Annotations	1.0	null
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
death	Phosphosite Textmining Biological Term Annotations	1.0	null
IMR-5	GDSC Cell Line Gene Expression Profiles	1.0	1.61903
GTEX-QVJO-0011-R2A-SM-2S1QK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33833
GSE205163,GSE205164_3_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
amoxapine-6650	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.36347
nuclear lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K78697404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01469
brain ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.12809
membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.051853
GSE211955_1_v_0_jmjd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282806
SNU1033	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46487
defense response	GO Biological Process Annotations 2015	1.0	null
PMC10099894-NAN-49-0-s001.xlsx-GENIC_INTERSECT_VCF-MID_TBX1	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3675-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
signal transduction by phosphorylation	GO Biological Process Annotations 2015	1.0	null
Sarcoma_SARC_TCGA-IS-A3K6-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cefotiam-2458	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hydralazine-4746	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-NL4W-0011-R10A-SM-2I3DY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11693
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65222
GSE114284_2_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_151_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE129241_4_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S7SE-0005-SM-2XCEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12774
GATA3_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
chlortalidone-1581	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC4262241__F3	PFOCR Pathway Figure Associations 2024	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GW-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mental Deterioration	DisGeNET Gene-Phenotype Associations	1.0	null
GSE152055_0_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876476
PMC2593012__F3	PFOCR Pathway Figure Associations 2023	1.0	null
PMC4252505__F3	PFOCR Pathway Figure Associations 2023	1.0	null
hsa-miR-1287	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
BRD-K78074905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59595
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_98_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
map kinase activity	GO Molecular Function Annotations 2015	1.0	null
mental depression	GWASdb SNP-Disease Associations	1.0	0.450567
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Sinomenine_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0262293
Sarcoma_SARC_TCGA-MO-A47P-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4700-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Myocardial Infarction	DisGeNET Gene-Disease Associations	1.0	null
BRD-K86300178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05558
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10103
rhombomere 11	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04797
PF-00539745-00-5979	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LM-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Carcinoma	CTD Gene-Disease Associations	1.0	1.1122
innate immune response-activating signal transduction	GO Biological Process Annotations 2015	1.0	null
vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.051188
MCF7_Nintedanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124294
PMC11079006-41467_2024_48118_MOESM7_ESM.xlsx-E2F6_OE_vs_EGFP_CTR_DE-gene_E2F6	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_2987_KO_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.79267
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.94377
GSE261563_0_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary somatosensory area, trunk, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13594
GSE142684_3_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9633745-mmc3.xlsx-Table_S2-Up-regulated_in_MSC-2_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
CASP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20039
DDR1	Kinase Library Tyrosine Kinome Atlas	1.0	98.05
Adrenocortical carcinoma_ACC_TCGA-OR-A5LL-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEP290	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10545357-medi-102-e35220-s002.xlsx-intersection_targets-NR3C2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
mammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16995
JSC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
r1 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.71447
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.36361
activation of innate immune response	GO Biological Process Annotations 2015	1.0	null
GSE173810_4_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE136627_2_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Abducens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15647
BRD-K89637567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3213
14-3-3	Phosphosite Textmining Biological Term Annotations	1.0	null
mapk cascade	GO Biological Process Annotations 2015	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
postsynaptic Golgi apparatus	SynGO Synaptic Gene Annotations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5ZD-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Postsubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69466
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41535
positive regulation of cell communication	GO Biological Process Annotations 2015	1.0	null
cytoplasm	GO Cellular Component Annotations 2015	1.0	null
icSARS CoV_60Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.45271
positive regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
embryonic carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.141405
Bed nuclei of the stria terminalis, anterior division, dorsomedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0724
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-8_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86937728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73898
BRD-K37269981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4011
AURKC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49921
GTEX-NL3H-0011-R4a-SM-2I3GK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976497
Brain Lower Grade Glioma_LGG_TCGA-HT-7695-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_131_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.32797
GSE217115_2_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21763
BRD-K50884475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45431
NCIH854	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54425
PCI15A	DepMap CRISPR Gene Dependency	1.0	7.07326
BRD-K82774801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98309
Dopaminergic synapse	KEGG Pathways 2026	1.0	null
A549_Aminoglutethimide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155164
SSTR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0055452
PMC8100301__F6	PFOCR Pathway Figure Associations 2024	1.0	null
tanespimycin-5566	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
receptors	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K07540687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93897
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05023
PMC5528331__F4	PFOCR Pathway Figure Associations 2023	1.0	null
GSE205163,GSE205164_5_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RCOR1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.7018
MCF7_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205889
hsa-miR-3679-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
mantle zone of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39803
AB-70-GR31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266026
Liver enzyme levels (alanine transaminase)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.852288
Trimetrexate_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.029445
CAV3_KO_GDS3533_17_mouse_mammary glands	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.31038
protein serine/threonine kinase activity	GO Molecular Function Annotations 2015	1.0	null
E2F1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
influenza	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.186811
PMC5859839__F11	PFOCR Pathway Figure Associations 2024	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.89956
GSE140997_2_v_8_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CEBPB_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-A4M7-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
shares	GeneRIF Biological Term Annotations	1.0	null
POU3F2-20337985-501MEL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF536	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9679
WEE1	Pathway Commons Protein-Protein Interactions	1.0	null
loxapine-1516	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4436b-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
GSE196117_6_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11370252-12864_2024_10619_MOESM2_ESM.xlsx-FEV1_AA-Gene_Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
HNRNPK	Pathway Commons Protein-Protein Interactions	1.0	null
GSE142684_3_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
terminus	GeneRIF Biological Term Annotations	1.0	null
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18562
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
PMC8423434-mmc7.xlsx-SOX2_HENSM-Genes_n_2733_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of cell communication	GO Biological Process Annotations 2015	1.0	null
GTEX-WHSE-0011-R4A-SM-3P5ZN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944391
N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	CTD Gene-Chemical Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7422-01A-21R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8566230-41388_2021_2018_MOESM3_ESM.xlsx-Cluster3_witn_MYCN_DEGs-Gene_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
IM-9	COSMIC Cell Line Gene Mutation Profiles	1.0	null
female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.108206
Microphthalmos	DisGeNET Gene-Disease Associations	1.0	null
hsa-miR-130a	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
PMC2866657-pone.0010547.s003.xls-ERG_corr-Genes_correlated_anticorrelated_to_ERG_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
BAD	Pathway Commons Protein-Protein Interactions	1.0	null
BICR18	CCLE Cell Line Gene CNV Profiles	-1.0	-1.91471
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.850623
Lipopolysaccharides	CTD Gene-Chemical Interactions	1.0	null
PMC11994887-Supplementaryfile1.pdf-5-GABPA_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
MAPK8IP3	Pathway Commons Protein-Protein Interactions	1.0	null
Accessory olfactory bulb, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.08873
furosemide-1580	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8339-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12629863-CAC2-45-1547-s002.xlsx-Supplementary_Table_S10-Supplementary_Table_S10_Kinases_predicted_to_phosphorylat_YY1_at_Ser247_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
Ixazomib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0153639
vigabatrin-2452	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE240386,GSE242143_1_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary auditory cortex (core)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.937097
regulation of protein phosphorylation	GO Biological Process Annotations 2015	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A4U1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Tanespimycin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019813
lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055776
hsa-miR-620	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Perturb_15385_KD_FGF13_SRP319157	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.9181
GSE214514_1_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12640816-DataSheet2.pdf-2-FOSB_FOSB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE143944_2_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52273
p75(NTR)-mediated signaling	PID Pathways	1.0	null
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Status Epilepticus	CTD Gene-Disease Associations	1.0	1.04978
BRD-K82570855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39864
PMC5819906__F7	PFOCR Pathway Figure Associations 2023	1.0	null
Neural Tube Defects	CTD Gene-Disease Associations	1.0	1.267
MCF7_Hesperadin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112285
jnk cascade	GO Biological Process Annotations 2015	1.0	null
NLK	Pathway Commons Protein-Protein Interactions	1.0	null
SP600125	DGIdb Drug Targets 2026	1.0	0.254481
Toll Like Receptor 5 (TLR5) Cascade	Reactome Pathways 2024	1.0	null
SUDHL10	CCLE Cell Line Gene Expression Profiles	1.0	1.64597
19808870-ST1	GeneSigDB Published Gene Signatures	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.01287
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60854
PKBalpha_KO_GDS1784_197_mouse_Embryonic fibroblasts (MEFs) - 48h	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.23409
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.849394
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
GSE223241_1_v_3_cdkn2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-302e	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
RECOMBINANT INTERFERON	DGIdb Drug Targets 2026	1.0	0.0522012
hsa-miR-4635	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Acute Myeloid Leukemia_LAML_TCGA-AB-2846-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_499_KD_PKR/BRF1_SRP382324	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.79985
Subparaventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27117
hsa-miR-4685-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0568
BRD-K05409106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48819
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC7368075__F2	PFOCR Pathway Figure Associations 2024	1.0	null
regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC3419980-leu201249x2.xls-RUNX1-ETO_siRE_ChIPSeq_peaks_ge-gene_name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.11
Perturb_9785_KD_EPS15_SRP339484	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.34347
superficial stratum of r2BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84169
SIMA	GDSC Cell Line Gene Expression Profiles	1.0	1.42174
Metformin	CTD Gene-Chemical Interactions	1.0	null
icSARA deltaORF6_54Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.78255
plexiform layer of TuStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25786
GTEX-QDVJ-1926-SM-2S1PJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.937519
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68192
NUGC3_STOMACH	CCLE Cell Line Proteomics	1.0	16.5651
BRD-K77343050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1329
Perturb_17425_OE_Gli2a_SRP141427	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.55335
GTEX-V1D1-2426-SM-3GAER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8702
ZR7530	CCLE Cell Line Gene Expression Profiles	1.0	1.52638
BRD-K74665927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11591
Atazanavir (sulfate)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0210233
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HAND1_HAND1	Rummagene Transcription Factor Associations 2026	1.0	null
IGR39	CCLE Cell Line Gene CNV Profiles	-1.0	-2.09316
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE126127_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056682
Perturb_15468_KD_TCEAL1_ERP123632	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.45935
CAMK2G	Pathway Commons Protein-Protein Interactions	1.0	null
GSE171179,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
decreased neuron apoptosis	MGI Mouse Phenotype Associations 2023	1.0	null
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63U-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12366_KD_SLC39A7_SRP274341	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.03275
MyD88 dependent cascade initiated on endosome	Reactome Pathways 2024	1.0	null
bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04649
Bed nuclei of the stria terminalis, anterior division, oval nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03013
BRD-K85395981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0656
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.02402
hsa-miR-4421	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Lung Injury	CTD Gene-Disease Associations	1.0	1.83272
Protein kinase domain	InterPro Predicted Protein Domain Annotations	1.0	null
PMC10803041-elife-86204-supp2.xlsx-snRNA-seq_Snc-KD_in_HT-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
t-24 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.315861
CRCGN015_MCF10A_48H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22789
embryonic stem cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.25457
PMC6521881__F2	PFOCR Pathway Figure Associations 2023	1.0	null
KRAS.600_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.5823
GTEX-X4XX-3026-SM-3NMB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63209
GSE223241_2_v_0_cdkn2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K33770771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7928
19185848-TableS4	GeneSigDB Published Gene Signatures	1.0	null
BRD-K43570522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28716
dorsolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34908
posteroventral (inferior) parietal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.51037
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40448
positive regulation of immune system process	GO Biological Process Annotations 2015	1.0	null
Leukopenia	CTD Gene-Disease Associations	1.0	1.02336
primary motor cortex (area M1, area 4)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.91143
BD-85-GY20_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238532
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.858802
Luteolin	CTD Gene-Chemical Interactions	1.0	null
SLC25A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77537
r5 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27047
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04473
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19538
abnormal somatic nervous system morphology	MPO Gene-Phenotype Associations	1.0	null
Ebolavirus(EBOV)_1day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.186572
PMC4450280__F5	PFOCR Pathway Figure Associations 2024	1.0	null
hsa-miR-3688-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46773
cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042625
Interleukin 1 IL 1 structural pathway	WikiPathways Pathways 2024	1.0	null
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.82137
Tolmetin_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0288289
ZC3H11A_02_44	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.70044
BRD-K91962463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06242
Prostatic Neoplasms	CTD Gene-Disease Associations	1.0	1.21534
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_51_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
IMPDH2	Pathway Commons Protein-Protein Interactions	1.0	null
simvastatin-4244	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF217	ENCODE Transcription Factor Targets	1.0	null
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.81059
APTO-253_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0087121
T3M4	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.5988
KIF26A	Pathway Commons Protein-Protein Interactions	1.0	null
MTHFD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00350817
brain disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
NRDC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01806
immune response	GO Biological Process Annotations 2015	1.0	null
Prestwick-682-4984	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23186
LCLC-103H	GDSC Cell Line Gene Expression Profiles	-1.0	-1.77036
BRD-K86721033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25472
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07887
NDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16258
SUPHD1	CCLE Cell Line Gene CNV Profiles	1.0	2.33399
disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CLPP_KO_GSE40207_379_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K62148271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38701
TAB1	Pathway Commons Protein-Protein Interactions	1.0	null
CD40/CD40L signaling	PID Pathways	1.0	null
MCF7_MC1568_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184165
Toll Like Receptor 9 (TLR9) Cascade	Reactome Pathways 2024	1.0	null
PMC5840674-ol-15-04-5517.nxml--ZBTB20_ZBTB20	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89893
BRD-K62612761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34925
GSE131649_4_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-5270-01A-02R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
supragenual nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14004
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915293
17571080-SuppTable2c	GeneSigDB Published Gene Signatures	1.0	null
PMC8025515-12859_2021_4105_MOESM12_ESM.xlsx-PW1-gene_stable_id_PEG3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202284,GSE202289_5_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXA1_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 2 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2344
layer 1 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18619
methotrexate-1957	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_10637_KO_Sip1_SRP028877	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE157960_2_v_3_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19071
PMC8144624-41598_2021_90212_MOESM7_ESM.xlsx-apla05132_Salm_LPS-Gene_ID_KEGG_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.10396
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040025
toll-like receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
VMRCLCP	CCLE Cell Line Gene CNV Profiles	-1.0	-2.69408
AOB, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.04156
Cystitis	CTD Gene-Disease Associations	1.0	1.41775
POU3F2-20337985-501MEL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SNRK_overexpression_127_GSE30185	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.33804
JUND-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC6113163__F4	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64957
Epileptic Drop Attack	DisGeNET Gene-Disease Associations	1.0	null
toll-like receptor 5 signaling pathway	GO Biological Process Annotations 2015	1.0	null
Vitamin K4_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0222125
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14821
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K91421454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2897
hsa-miR-940	TargetScan Predicted Conserved microRNA Targets	1.0	0.127531
Alzheimer 39 s disease	WikiPathways Pathways 2024	1.0	null
BRD-A33119430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13243
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3TQ-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
vinburnine-1788	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ERP44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01668
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A5KF-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
immune response-regulating cell surface receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
BRD-K77024507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.77122
protein-transport	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847057
Perturb_6787_KD_KRAS_ERP122260	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Interferon-gamma signaling pathway	PANTHER Pathways	1.0	null
A549_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183123
PMC10679662-mmc3.xlsx-NC-D5-ZEB2-Mutant-Downregulated-Gene_Symbol_ZEB2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K97638135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69615
Perturb_6621_KO_NEUROD1_SRP388830	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.02935
striohypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07084
cellular response to stimulus	GO Biological Process Annotations 2015	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839574
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26876
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.22374
Perturb_12266_OE_Lnc152_SRP354956	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.08606
posteroventral (inferior) parietal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09675
FCERI mediated MAPK activation	Reactome Pathways 2024	1.0	null
review	GeneRIF Biological Term Annotations	1.0	null
DLX5_KO_GSE22381_5_mouse_ear (otic vesicle)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
pattern recognition receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.064188
GSE68156_0_v_1_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
macromolecule modification	GO Biological Process Annotations 2015	1.0	null
Activation of the AP-1 family of transcription factors	Reactome Pathways 2014	1.0	null
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.656617
hsa-miR-449c	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
JOSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28692
thioridazine-4164	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DCTN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72191
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
MYC	Pathway Commons Protein-Protein Interactions	1.0	null
PMC5054603__F3	PFOCR Pathway Figure Associations 2023	1.0	null
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.069201
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE102505_5_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
type ii diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.487836
PMC4219530__F1	PFOCR Pathway Figure Associations 2024	1.0	null
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
CLCN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18382
Diarrhea	CTD Gene-Disease Associations	1.0	1.18685
Acute Myeloid Leukemia_LAML_TCGA-AB-2823-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE126345_2_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FLNC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76492
PMC8036964__F7	PFOCR Pathway Figure Associations 2024	1.0	null
Demyelinating Diseases	CTD Gene-Disease Associations	1.0	1.26978
PMC8144624-41598_2021_90212_MOESM7_ESM.xlsx-apla05164_AIV_LPS-Gene_ID_KEGG_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.10763
GSE135030_8_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140651,GSE140653_5_v_7_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185163_5_v_2_clic4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4732610__F6	PFOCR Pathway Figure Associations 2024	1.0	null
bronchoalveolar lavage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.48087
GTEX-O5YU-0008-SM-4E3I7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882017
nervous system disease	GWASdb SNP-Disease Associations	1.0	0.047422
Oxidative Stress Induced Senescence	Reactome Pathways 2014	1.0	null
MYC-27129775-CHIP-SEQ-CORNEA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
small cell lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.226667
CFAP68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03428
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03136
hsa-miR-4320	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
closely	GeneRIF Biological Term Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Childhood Burkitt Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
GSE71468,GSE76476_2_v_1_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_16899_KO_Sp8/Sp9_SRP115902	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-19.2218
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17016
SARS-ddORF6_72Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.17808
bromocriptine-1507	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.9906
camp	Phosphosite Textmining Biological Term Annotations	1.0	null
MAPK14	Pathway Commons Protein-Protein Interactions	1.0	null
MAPK signaling pathway(Mus musculus)	WikiPathways Pathways 2014	1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1355
pulmonary artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.183116
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.43955
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20682
BRD-K49094605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0932
LS180	CCLE Cell Line Gene Mutation Profiles	1.0	null
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	Reactome Pathways 2024	1.0	null
Cellular Senescence	Reactome Pathways 2024	1.0	null
PMC4390530-NIHMS667786-supplement-1.xlsx-Sheet1-Supplementary_Table_2_Genes_closest_to_AR_induced_ASH2L_peaks_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5697-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
protein kinase activity	GO Molecular Function Annotations 2015	1.0	null
BRD-A27844016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95093
STAT1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K61924304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2766
Type II diabetes mellitus	KEGG Pathways 2026	1.0	null
BRD-K85055578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0364
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061866
KLF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25541
mitochondrial	Phosphosite Textmining Biological Term Annotations	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.72675
A549_Hesperadin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119594
Primary somatosensory area, barrel field	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12795
XD-68-MP63_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.478272
Orbital area, medial part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43572
Bladder Urothelial Carcinoma_BLCA_TCGA-LT-A5Z6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K80888628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36048
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52049
BRD-K47366416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06489
PMC4540202-cddis2014370x2.xls-Sheet1-Table_S2_MEIS2-responsive_genes_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
TBX3-20139965-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EGR1	ChEA Transcription Factor Targets	1.0	null
Sivelestat (sodium tetrahydrate)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0242207
PMC9268799__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Uterine Cervical Neoplasms	CTD Gene-Disease Associations	1.0	1.67675
hsa-miR-509-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-K34858602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60102
CREB1	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02301
PMC12354803-42003_2025_8643_MOESM2_ESM.xlsx-2w_TP63_positive-Gene_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
ERG28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6621
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
regulation of biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Perturb_7355_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.5028
organelle	GO Cellular Component Annotations 2015	1.0	null
FAS signaling pathway	PANTHER Pathways	1.0	null
PMC11496110-42255_2024_1140_MOESM3_ESM.xlsx-ST18_Gene_view-Unnamed_1_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-632	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Brain_Germinal_Matrix	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.3011
GTEX-X4XX-0011-R1B-SM-3P622	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841721
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.10025
Lung adenocarcinoma_LUAD_TCGA-91-6835-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rostral paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25662
layer 4 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41431
GTEX-QVUS-2826-SM-3GADB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21904
A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_4day-MOI-10^4_None_GSE43301	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.77191
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.9831
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.904571
GSE88819_3_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06973
metencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064069
pglycoproteinmediated	GeneRIF Biological Term Annotations	1.0	null
BUB1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00518908
Parasubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04654
Chagas disease	KEGG Pathways 2026	1.0	null
PMC9305137-PATH-256-297-s005.xlsx-CIC_associated_DE_genes_IDH1-R-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.1385
KALS1	CCLE Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-203	TargetScan Predicted Conserved microRNA Targets	1.0	0.154935
Lung adenocarcinoma_LUAD_TCGA-L9-A443-01A-12R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.11311
CRCGN017_MCF10A.WT.HP_24H:P09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8599
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00457
GTEX-WZTO-0011-R5B-SM-3NMC5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922638
Perturb_9992_KD_PABPC1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.70399
hsa-miR-4287	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_673_KO_IRF5_SRP212091	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.97446
GTEX-T6MN-0011-R4A-SM-32QPG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949947
GSE118816_2_v_1_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Carcinoma, Non-Small-Cell Lung	CTD Gene-Disease Associations	1.0	1.01474
Dihydrotestosterone	CTD Gene-Chemical Interactions	1.0	null
bronchoalveolar system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069468
PMC7096153__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29201
EIF2S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	6.53413
BRD-K82145108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6836
gnrh signaling pathway	KEGG Pathways	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
increased hematocrit	MPO Gene-Phenotype Associations	1.0	null
ES5	DepMap CRISPR Gene Dependency	1.0	2.2055
BRD-K86981519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.55802
PMC3804941-supp_jem.20122709_JEM_20122709_TableS1.xlsx-Suppl_Table_1C-1772_genes-Table_S1_C_1_772_significantly_overexpressed_genes_during_AR_when_combining_p-values_at_FDR_20_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5109294-celldisc201641-s3.xls-NANOGP8_DEGs-Unnamed_10_NANOGP8	Rummagene Transcription Factor Associations 2026	1.0	null
HPAFII	CCLE Cell Line Gene Mutation Profiles	1.0	null
IRF1-21803131-MONOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-105	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE121824,GSE121826_0_v_2_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Estrone sulfate (potassium)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0363612
GSE166004_3_v_2_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42897
ATN1	Hub Proteins Protein-Protein Interactions	1.0	null
mapk10	GeneRIF Biological Term Annotations	1.0	null
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46667
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
cytosol	GO Cellular Component Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7874-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW837	CCLE Cell Line Gene Mutation Profiles	1.0	null
bringing	GeneRIF Biological Term Annotations	1.0	null
Epstein-Barr virus infection	KEGG Pathways 2026	1.0	null
ARH77	DepMap CRISPR Gene Dependency	1.0	2.89127
Quercetin	CTD Gene-Chemical Interactions	1.0	null
Oxidative Stress(Mus musculus)	WikiPathways Pathways 2014	1.0	null
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-Genes_with_ATF3_combined_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77817
isoniazid-1399	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JHU029	DepMap CRISPR Gene Dependency	1.0	3.94477
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16225
GATM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06256
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.325731
Perturb_15775_OE_Nmnat1_SRP360949	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.52759
CRCGN016_MCF10A.TP53.M_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3895
BRD-K84601599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02701
BRD-K96627018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01381
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_137_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
zidovudine-1595	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
peptidebinding	GeneRIF Biological Term Annotations	1.0	null
LU134A	DepMap CRISPR Gene Dependency	1.0	2.28165
NB-92-BG38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.33073
GSE153836_14_v_5_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Tubulin inhibitor 6_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0377346
BRD-K17840858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14759
Lung squamous cell carcinoma_LUSC_TCGA-18-3416-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K41323747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55679
Pulmonary Fibrosis	CTD Gene-Disease Associations	1.0	1.09611
HIF1A_DEPLETION_GDS2760_642_human_Hypoxic MCF-7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
MCF7_TMP195_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139074
retrosplenial cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36699
TCF4-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-T6MN-0011-R6A-SM-32QP8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03849
Perturb_267_KO_ADIRFAS786_SRP366780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.93878
DOHH2	CCLE Cell Line Gene Expression Profiles	1.0	1.73247
Accessory olfactory bulb, mitral layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.28703
Perturb_12667_OE_MX2_SRP308919	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.43711
BRD-A98795688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.101
ventrolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08487
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
cromoglicic acid-5754	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K71870778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69963
Perturb_14161_KD_BZW1/BZW2_SRP316321	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.36829
GSE200673,GSE200691_1_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3WC-01A-31R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QMR6-0011-R2A-SM-32PKV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01024
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22014
PMC7366109__F5	PFOCR Pathway Figure Associations 2023	1.0	null
PRKD2	Pathway Commons Protein-Protein Interactions	1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.70409
GSE92364_1_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K60255752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11951
ZNF217_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12923
CAMA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.993546
BRD-K81725246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50053
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3467-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IFNGR2	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HG-A2PA-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retinoic acid_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0260429
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883053
SP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19713
hsa-miR-3660	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
BRD-K99530482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02776
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_HSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Infertility, Male	CTD Gene-Disease Associations	1.0	1.87742
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.402187
fendiline-1573	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08207
tiratricol-2259	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K76500652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12947
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0538
Epilepsy	DisGeNET Gene-Disease Associations	1.0	null
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.31106
PMC4219530__F1	PFOCR Pathway Figure Associations 2023	1.0	null
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09985
Perturb_3009_KD_HNF1alpha/HNF1beta_SRP067843	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.47482
KYSE410	CCLE Cell Line Gene Mutation Profiles	1.0	null
Adagrasib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0229507
ABL1	Pathway Commons Protein-Protein Interactions	1.0	null
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326967
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_3010_KD_PAX2_SRP119912	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.54799
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.841825
delineating	GeneRIF Biological Term Annotations	1.0	null
PMC12290113-41598_2025_12350_MOESM1_ESM.pdf-4-GATA6-AS1_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K12340493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01017
G13 signaling	WikiPathways Pathways 2024	1.0	null
BRD-K45894579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65592
TP53-18474530-U2OS-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
layer 5 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08865
PMC2872883__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GSE111660_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5868815__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Cystic Fibrosis	HuGE Navigator Gene-Phenotype Associations	1.0	null
DORAMAPIMOD	DGIdb Drug Targets 2026	1.0	0.0484725
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12887
Perturb_8763_KD_ROBO1_SRP158939	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.51204
GSE153443_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JAK2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE144231_4_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TSE9-0011-R4A-SM-3DB7H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07615
MCF7_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142991
BCR	Pathway Commons Protein-Protein Interactions	1.0	null
cyclin-dependent	Phosphosite Textmining Biological Term Annotations	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE154081_1_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
captopril-1907	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MCF7_Dasatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144773
GSE167956_4_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17982
MCF7_AG-490_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143474
Perturb_11354_KD_METTL3_SRP292229	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.04703
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5676-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-WVLH-0011-R5A-SM-3MJFW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889689
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A82E-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
perhexiline-5081	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Tight junction	KEGG Pathways 2026	1.0	null
A549_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013521
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.85972
MCF7_Tranylcypromine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158376
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1579
Artesunate_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0221385
cascades	GeneRIF Biological Term Annotations	1.0	null
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0118
HSPA1A	Hub Proteins Protein-Protein Interactions	1.0	null
BRD-K82877426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.47419
GTEX-QDT8-0011-R6A-SM-32PKI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881634
BRD-K28448768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15961
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-ATF3_TGACGTCA_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
SKN-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Hypothalamus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.927868
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03565
especially	GeneRIF Biological Term Annotations	1.0	null
regulation of mapk cascade	GO Biological Process Annotations 2015	1.0	null
GTEX-OIZG-0008-SM-4E3J2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87082
salsolidin-2824	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9221389__F8	PFOCR Pathway Figure Associations 2024	1.0	null
regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0858
Pregnancy Complications	CTD Gene-Disease Associations	1.0	1.02634
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_115_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Kaposi sarcoma-associated herpesvirus infection	KEGG Pathways 2026	1.0	null
etiocholanolone-4298	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE162688_1_v_2_pink1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QVUS-0011-R1A-SM-3GAD2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931938
Rectum adenocarcinoma_READ_TCGA-AG-3742-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.783557
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052695
NGFR	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Luminespib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207811
snoutepidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.57019
GTEX-P4QT-0008-SM-48TDZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838757
CAL78	CCLE Cell Line Gene CNV Profiles	1.0	1.80669
Perturb_12702_OE_ERG/FLI1_SRP397680	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.44401
PMC7617064-EMS151900-supplement-Figure_7_Source_Data.xlsx-HLC_D9_DEG-Logfold_change_threshold_1_0_1_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.775403
Perturb_4369_KD_SUZ12_SRP071040	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.9223
GSE219195_1_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
mitogen-activated-protein-kinases	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K65464642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79393
srf_17591768_igmpos_igdpos_b_cells_lof_mouse_gpl339_gds2805	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.675684
GSE146072_0_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.10336
atp binding	GO Molecular Function Annotations 2015	1.0	null
alcoholic hepatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.328834
phosphorylation	GeneRIF Biological Term Annotations	1.0	null
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.83163
Stomach Ulcer	CTD Gene-Disease Associations	1.0	1.01025
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Malotilate_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0375087
posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.75512
PLIN2	Pathway Commons Protein-Protein Interactions	1.0	null
Vision Disorders	CTD Gene-Disease Associations	1.0	1.44517
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.1303
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PHF20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4139
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XP-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cos-cells	Phosphosite Textmining Biological Term Annotations	1.0	null
intermediate stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33973
Vitamin K 3	CTD Gene-Chemical Interactions	1.0	null
Wnt signaling and pluripotency	WikiPathways Pathways 2024	1.0	null
GSE63048_11_v_5_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LTBR_INHIBITION - 27 Day_GDS2005_731_mouse_Lymph nodes  (MG-430B)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-XMD1-0011-R8A-SM-4AT48	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869493
mantle zone of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00575
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5984-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-8496-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2285_OE_TLX_SRP358206	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.23961
BRD-K76672145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.5297
A549_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187718
ACSS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18765
Seizures, Focal	DisGeNET Gene-Phenotype Associations	1.0	null
SP-600125	DGIdb Drug Targets 2026	1.0	0.0228747
Niclosamide (olamine)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0271155
GSE165704_0_v_1_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
pyramidal neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.406694
klf4_17017123_rko_gof_human_gpl96_gds1942	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.243895
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6090-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nanoparticle mediated activation of receptor signaling	WikiPathways Pathways 2024	1.0	null
Testicular Diseases	CTD Gene-Disease Associations	1.0	1.50549
GNE-3511	DGIdb Drug Targets 2026	1.0	0.169654
TE-15	GDSC Cell Line Gene Expression Profiles	1.0	1.87086
H3K27ac_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JUND	Pathway Commons Protein-Protein Interactions	1.0	null
GSE203158_0_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151612_4_v_11_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K39985369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47891
ISHIKAWAHERAKLIO02ER	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-NPJ8-0011-R3a-SM-2HMIW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92481
AOB, mitral cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.41851
levobunolol-3354	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
regulation of immune response	GO Biological Process Annotations 2015	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.38084
Leukemia	DisGeNET Gene-Disease Associations	1.0	null
MCF7_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204606
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03902
GSE99687_3_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of response to stimulus	GO Biological Process Annotations 2015	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2889-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.984508
HCE4	DepMap CRISPR Gene Dependency	1.0	3.82835
Perturb_9130_KD_PHGDH_ERP020769	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.25623
BRD-K30674856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30363
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
ventral claustrum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28223
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3664
N-acetyl-L-leucine-6462	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lapatinib ditosylate_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0360381
Liver Cirrhosis, Experimental	CTD Gene-Disease Associations	1.0	1.165
BRD-K51654114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.7184
Wnt signaling in kidney disease	WikiPathways Pathways 2024	1.0	null
regulation of molecular function	GO Biological Process Annotations 2015	1.0	null
CMTR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45959
Perturb_14971_KD_Crebbp_SRP154933	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.29431
GSE226249_5_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Human T-cell leukemia virus 1 infection	KEGG Pathways 2026	1.0	null
H3K27me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Hydroxyfasudil_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0245444
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.34821
Dorsal peduncular area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12401
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.832568
PMC10559929__F5	PFOCR Pathway Figure Associations 2024	1.0	null
5q35 copy number variation	WikiPathways Pathways 2024	1.0	null
urethritis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.504973
hsa-miR-3619-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
MAPK8IP2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Angiopoietin like protein 8 regulatory pathway	WikiPathways Pathways 2024	1.0	null
icSARA deltaORF6_72Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.52184
fulvestrant-5565	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intermediate stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.00123
GTEX-P4PP-0008-SM-48TDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.996499
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-OXRL-1626-SM-2YUMU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18076
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952432
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A3Y1-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6378-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-96-8170-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.671692
intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5986-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Insulin signaling	WikiPathways Pathways 2024	1.0	null
layer 4 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32752
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
APP	Pathway Commons Protein-Protein Interactions	1.0	null
TJP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20013
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09521
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_345_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Belumosudil (mesylate)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0341927
PMC6078853-molce-41-7-695-suppl2.xlsx-Sheet1-Table_S1_Genes_exhibiting_two-fold_changes_in_expression_between_WT_and_CTCF_KO_otocyst_with_FDR_less_than_0_05_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
SKNFI	CCLE Cell Line Gene Expression Profiles	1.0	1.55255
IL-17 signaling pathway	KEGG Pathways 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5884-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Ovarian Neoplasms	CTD Gene-Disease Associations	1.0	1.65091
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SARS-BatSRBD_24Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.64344
EP300	ENCODE Transcription Factor Targets	1.0	null
FZD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09446
18787207-TableS2	GeneSigDB Published Gene Signatures	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
Jaw Keratocyst	DisGeNET Gene-Disease Associations	1.0	null
Ropivacaine (hydrochloride monohydrate)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0216971
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.2486
IMATINIB	DGIdb Drug Targets 2026	1.0	0.0139441
Spi1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	54.0926
BRD-K56836463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09948
Status Epilepticus	DisGeNET Gene-Disease Associations	1.0	null
icSARS CoV_36Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.05823
PMC11198785-pone.0305217.s001.xlsx-Sheet1-Regulatory_circuits_of_the_STAT3_signaling_pathway_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
megacolon	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.196459
MZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04816
Perturb_6311_KO_MIR221/MIR222_SRP073023	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.63342
OB olfactory fiber layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52431
TCF12	ENCODE Transcription Factor Targets	1.0	null
celecoxib-377	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pilocarpine-2438	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
gonorrhea	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.583941
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QH-01A-21R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K55727377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25756
signal transducer activity	GO Molecular Function Annotations 2015	1.0	null
Activated TLR4 signalling	Reactome Pathways 2014	1.0	null
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.879791
Immune System	Reactome Pathways 2014	1.0	null
FOSL2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95425
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60773
Perturb_4269_KD_CDK7_SRP301955	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.19529
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.210203
Lung adenocarcinoma_LUAD_TCGA-55-6986-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K84936524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20705
DUSP10	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_6786_Mut_KRAS_ERP122260	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
19621087-Table1d	GeneSigDB Published Gene Signatures	1.0	null
RALA	Pathway Commons Protein-Protein Interactions	1.0	null
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	1.80134
Brain Lower Grade Glioma_LGG_TCGA-HT-7469-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
EBF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3044
PMC3291562__F4	PFOCR Pathway Figure Associations 2023	1.0	null
CRCGN015_HEPG2_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.3731
IPC298	CCLE Cell Line Gene CNV Profiles	1.0	1.76558
GSE174701_4_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K79730625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.46959
CRCGN017_MCF10A.WT.HP_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.427
GSE180641_0_v_1_zfp503_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A14098586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43792
GSE216273,GSE216292_14_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
silent	GeneRIF Biological Term Annotations	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A7Q1-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JC-0011-R2A-SM-32PLZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853061
19505326-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.04169
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839574
SB202190	DGIdb Drug Targets 2026	1.0	0.058167
renal tubule epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.735559
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	1.0	4.02866
Translation inhibitors in chronically activated PDGFRA cells	WikiPathways Pathways 2024	1.0	null
CRCGN008_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.57535
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
regulation of rna biosynthetic process	GO Biological Process Annotations 2015	1.0	null
H2BK120ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SKN3	DepMap CRISPR Gene Dependency	1.0	2.58277
Perturb_4905_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.95203
toxic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.186811
membrane-glycoproteins	Phosphosite Textmining Biological Term Annotations	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_123_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.38015
GTEX-NPJ8-0011-R11A-SM-2YUMS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88055
MCF7_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117998
KMS11	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.27224
CREBBP	Hub Proteins Protein-Protein Interactions	1.0	null
BRD-K69960043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05359
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044207
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BOS172722	DGIdb Drug Targets 2026	1.0	0.169654
cisapride-6706	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Mitophagy - animal	KEGG Pathways 2026	1.0	null
layer 2 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29384
Kidney Diseases	CTD Gene-Disease Associations	1.0	2.31797
HCK	Pathway Commons Protein-Protein Interactions	1.0	null
SMAD3-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K56161905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16434
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7897-01A-21R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12093
CP-690334-01-4383	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_668_KO_CX_SRP212091	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.92472
IM95	CCLE Cell Line Gene Mutation Profiles	1.0	null
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04769
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal dopamine level	MPO Gene-Phenotype Associations	1.0	null
Perturb_14900_KO_H15_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.44113
GTEX-X5EB-1826-SM-4E3K8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859757
Atypical Absence Seizure	DisGeNET Gene-Disease Associations	1.0	null
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60817
cell culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.21573
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.825947
RH18	CCLE Cell Line Gene Expression Profiles	-1.0	-1.86516
BRD-K39267096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09458
embryonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07206
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
positive regulation of phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
Leukemia	CTD Gene-Disease Associations	1.0	1.33583
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.33
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.99406
Leishmaniasis	DisGeNET Gene-Disease Associations	1.0	null
PMC5819906__F7	PFOCR Pathway Figure Associations 2024	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.82481
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.5857
Entecavir (monohydrate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.017388
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-HAND1_neg_targets-Gene_HAND1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7825356-8844261.f3.docx-110-ZFAT_ZFAT	Rummagene Transcription Factor Associations 2026	1.0	null
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.904097
kidney disease	GWASdb SNP-Disease Associations	1.0	0.844278
MYC-19915707-AK7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K31021810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.93999
abnormal locomotor behavior	MPO Gene-Phenotype Associations	1.0	null
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.04712
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A431-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K48221699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10654
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.713779
hsa-miR-193b	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.078665
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52273
BRD-K50718861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14196
PAK1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-7696-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
neurodegenerative disease	GWASdb SNP-Disease Associations	1.0	0.247602
protein serine/threonine/tyrosine kinase activity	GO Molecular Function Annotations 2023	1.0	null
PMC3669416-pone.0064838.s001.xls-mHTT-HOXB1_HOXB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157555,GSE157556_4_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OXRN-2426-SM-2I5EQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39571
Postsubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70832
regulation of nucleic acid-templated transcription	GO Biological Process Annotations 2015	1.0	null
TBX3-20139965-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Oxidative Stress(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A82B-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
positive regulation of kinase activity	GO Biological Process Annotations 2015	1.0	null
hsa-miR-221	TargetScan Predicted Conserved microRNA Targets	1.0	0.103424
GSE135030_3_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
streptomycin-1578	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_15521_OE_proL1_SRP277452	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.8794
LJI308_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0167534
Prostate-hillock-club cell of prostate epithelium	Tabula Sapiens Gene-Cell Associations	1.0	1.14224
positive regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6939-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K18435317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16111
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047644
alpha-yohimbine-2778	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PF-562271	DGIdb Drug Targets 2026	1.0	0.00978772
PMC2724029__F5	PFOCR Pathway Figure Associations 2023	1.0	null
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.7146
BRD-K10635555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57369
GTEX-X585-0011-R1B-SM-46MVE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24036
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0045223
nucleus	LOCATE Curated Protein Localization Annotations	1.0	null
KIT	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
18631401-TableS3	GeneSigDB Published Gene Signatures	1.0	null
GSE149035_2_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	1.0	null
isoetharine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29649
Innate Immune System	Reactome Pathways 2024	1.0	null
Structural Pathway of Interleukin 1 (IL-1)(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
Perturb_7929_KD_ZCCHC8_SRP222099	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.96485
primary somatosensory cortex (area S1, areas 3,1,2)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.20443
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973895
retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069979
cytosol	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K99331869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13836
Leukemia, Acute Megakaryocytic_Megakaryocyte_GSE2433	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.50714
Anterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20347
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824989
CRCGN008_HEPG2_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10945
GSE153757,GSE153758_0_v_2_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K36031198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45986
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-7631-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RMC-6236_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0426644
Neurotrophin signaling pathway	KEGG Pathways 2026	1.0	null
schizophrenia	GWASdb SNP-Phenotype Associations	1.0	0.55667
interactions	GeneRIF Biological Term Annotations	1.0	null
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8351
PMC7057487__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GSE101239_4_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
oxide	Phosphosite Textmining Biological Term Annotations	1.0	null
organelle part	GO Cellular Component Annotations 2015	1.0	null
Paclitaxel_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0332787
toll-like receptor 3 signaling pathway	GO Biological Process Annotations 2015	1.0	null
r7 part of the posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51097
Perturb_7957_KD_ZCCHC8_SRP222099	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.35563
outer CP in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.85812
CARNS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16573
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11185762-media-2.xlsx-ATAC2wk_KD_V337M_intersect_peak-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5417597-pone.0176679.s006.xlsx-Tumor_MLL_vs_Control-Unnamed_1_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
FZD2	Pathway Commons Protein-Protein Interactions	1.0	null
Hypotension	CTD Gene-Disease Associations	1.0	1.31596
abnormality of immune system physiology	GWASdb SNP-Phenotype Associations	1.0	0.095354
BRD-A04510218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29283
NCIH716	CCLE Cell Line Gene CNV Profiles	1.0	1.57582
troglitazone-370	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.993546
GSE111660_2_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DMS153	CCLE Cell Line Gene CNV Profiles	1.0	1.57546
17234769-TableS2b	GeneSigDB Published Gene Signatures	1.0	null
BRD-K12959846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09891
GSE148252_1_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UMRC6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47993
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26242
p-19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.29996
G13 Signaling Pathway(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.84332
Fingolimod (hydrochloride)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0316858
BRD-K40358491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20675
BRD-A35871558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07695
CLSTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82255
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9474
PMC4531812-13058_2015_618_MOESM11_ESM.xlsx-TCGA_Sparse_KM-TFAP2B_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE105406_0_v_3_ptcd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of signal transduction	GO Biological Process Annotations 2015	1.0	null
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.70092
Alopecia	CTD Gene-Disease Associations	1.0	1.03235
clozapine-5589	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Integrin-mediated Cell Adhesion(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
Perturb_9782_KD_Esrrb_SRP321923	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.74421
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAPAN2	CCLE Cell Line Gene CNV Profiles	1.0	1.80508
BRD-K93613839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57311
Gastrointestinal Diseases	CTD Gene-Disease Associations	1.0	1.42696
GSE128634,GSE128636_1_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE155031_6_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K10876822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.62332
BRD-K85741537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17549
fluoxetine_mus musculus_gds2803	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Sarcoma_SARC_TCGA-IW-A3M4-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JNK INHIBITOR 9L	DGIdb Drug Targets 2026	1.0	0.508961
GSE205163,GSE205164_9_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09466
SP in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.861017
MYC	Hub Proteins Protein-Protein Interactions	1.0	null
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.689634
PMC11568168-41598_2024_79607_MOESM3_ESM.xls-11-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
ventrolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.27651
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900029
posteroventral (inferior) parietal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.847879
GSE128333_2_v_1_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
endometritis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.472225
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7932
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-6030-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal dopamine level	MGI Mouse Phenotype Associations 2023	1.0	null
Perturb_14050_OE_NFIB_SRP281947	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.29296
Perturb_17806_KO_ZNF675_SRP304971	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.56967
GF-15-LT47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301365
Chemical carcinogenesis - reactive oxygen species	KEGG Pathways 2026	1.0	null
iopamidol-5832	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Primary somatosensory area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03163
TAK-733_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0162041
UM-UC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03025
H3K4me1_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K84128738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02129
abnormal erythropoiesis	MPO Gene-Phenotype Associations	1.0	null
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01544
PMC12917211-Table1.xlsx-Table_S13-Table_S13_Gene-level_perturbation_statistics_from_the_virtual_KLF5_knockout_model_in_malignant_ductal_cells_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_15458_KD_TIP5_SRP198493	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.7469
cell part	GO Cellular Component Annotations 2015	1.0	null
PDGFR-beta signaling pathway	PID Pathways	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IJ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210580_0_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NF-21-HQ00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.424847
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.778318
Adult Burkitt Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
PMC9253713-mmc3.xls-sufu_KD_HCC1954_DEGs-Supplementary_Table_2_Differentially_expressed_genes_upon_knockdown_of_SUFU_compared_to_control_in_HCC1954_cells_Related_to_Figure_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A11130173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57985
Perturb_4199_KO_Fmr1_SRP075646	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.11863
Generalized Myoclonic Seizures	DisGeNET Gene-Disease Associations	1.0	null
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE234340_3_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5372489__F3a	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K46994278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93688
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_10698_KD_CD274_SRP307356	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.514
pc12-cells	Phosphosite Textmining Biological Term Annotations	1.0	null
Perturb_14883_KO_H11_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.98602
Lung Diseases	HuGE Navigator Gene-Phenotype Associations	1.0	null
A549_Ramelteon_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015576
PMC9534852-41598_2022_20572_MOESM4_ESM.xlsx-Sheet1-Supplementary_Table_S4_Transcriptomic_data_related_to_AHR_function_considered_for_metabolic_reconstruction_model_generation_AHR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01479
agonists	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68717
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_126_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Retrosplenial area, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40373
cervix disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.539667
Perturb_2336_KD_WBP11_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.74989
GSE143406_1_v_0_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RCOR1	ChEA Transcription Factor Targets	1.0	null
r5 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42436
Severe acute respiratory syndrome (SARS)_Peripheral blood mononuclear cell_GSE1739	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.48538
GSE174701_4_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Neuroblastoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K85664064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92912
Perturb_3469_KO_Gsa_SRP045496	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-K79547691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65785
PMC11385366-Table2.xlsx-DBP-Overlapped_Gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
Uterine Diseases	CTD Gene-Disease Associations	1.0	1.22884
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Edema	CTD Gene-Disease Associations	1.0	2.1636
Rucaparib (phosphate)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0277691
positive regulation of response to stimulus	GO Biological Process Annotations 2015	1.0	null
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051516
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A688-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K92791036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51916
SLC30A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04734
intracellular part	GO Cellular Component Annotations 2015	1.0	null
Hydrogen Peroxide	CTD Gene-Chemical Interactions	1.0	null
Response to cytidine analogues (gemcitabine)	GWAS Catalog SNP-Phenotype Associations	1.0	0.129504
GGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96437
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52273
(3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime	DrugBank Drug Targets	1.0	null
BRD-K03035008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44639
abnormal cell death	MPO Gene-Phenotype Associations	1.0	null
Perturb_4224_Mut_Smarcc1_SRP034621	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.70924
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.53806
captopril_mus musculus_gpl1261_gds3683	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U412-2026-SM-4DXSI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854451
forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_15569_OE_ITGA2_SRP134086	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.64281
GSE142019,GSE142021_10_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_15146_KD_CUX1_SRP343012	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.57798
temporal lobe	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-WWYW-0011-R6A-SM-3NB3G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961314
PMC11836325-41467_2025_56634_MOESM8_ESM.xlsx-gene_table_NGS5844-Supplementary_Data_6_Gene_targets_lost_in_resistant_cells_upon_FOSL1_knockdown_and_their_corresponding_hallmark_pathway_FOSL1	Rummagene Transcription Factor Associations 2026	1.0	null
Pt(O,O'-acac)(gamma-acac)(DMS)	CTD Gene-Chemical Interactions	1.0	null
CREBBP	Pathway Commons Protein-Protein Interactions	1.0	null
GSE227891_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KP-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
rpmi8226	HPA Cell Line Gene Expression Profiles	-1.0	-0.894171
Perturb_15455_KD_E2F1_SRP165775	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.21606
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.07284
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839838
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7254-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
positive regulation of protein phosphorylation	GO Biological Process Annotations 2015	1.0	null
artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043716
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03026
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_6502_KO_SOCS3_SRP168556	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.7968
GSE99687_2_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lingula (I)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71005
Premature Birth	CTD Gene-Disease Associations	1.0	1.08619
PMC3291562__F4	PFOCR Pathway Figure Associations 2024	1.0	null
dorsomedial part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00239
ChIP_TBX3_20139965	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
ELK1	Pathway Commons Protein-Protein Interactions	1.0	null
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.838048
Fatty Liver	CTD Gene-Disease Associations	1.0	1.56681
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.5851
PMC11558691-tables5_bbae592.xlsx-HNF4A-Genes_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
DUSP1	Pathway Commons Protein-Protein Interactions	1.0	null
Fluid shear stress and atherosclerosis	KEGG Pathways 2026	1.0	null
Perturb_2304_KD_CDC73_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.39245
CAMK2A	Pathway Commons Protein-Protein Interactions	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06753
YAP1-20516196-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
FLVCR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43505
BRD-K89364982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08465
BRD-K14233531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24876
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44632
GSE129241_3_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CAL29	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40511
PMC10785768-crc-22-0464-s04.xlsx-Supplementary_Table_S4-Supplementary_Table_S4_This_file_contains_a_list_of_the_common_top_significant_survival_associated_genes_in_both_Black_AA_and_White_cohorts_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195514_0_v_1_stk25_human	RummaGEO Gene Perturbation Signatures	-1.0	null
2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide	DrugBank Drug Targets	1.0	null
BRD-K69238239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75135
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93444
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.838793
CLPP_KO_GDS4791_106_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZF-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04405
19185848-Table1	GeneSigDB Published Gene Signatures	1.0	null
palbociclib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0193357
Parkinson Disease	DisGeNET Gene-Disease Associations	1.0	null
Primary somatosensory area, unassigned, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26164
GSE111247_11_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Serine/threonine/dual specificity protein kinase, catalytic  domain	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K58149231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26194
superficial stratum of isBI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67634
LTBR_INHIBITION - 35 Day_GDS2005_732_mouse_Lymph nodes  (MG-430B)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
C3A	CCLE Cell Line Gene Mutation Profiles	1.0	null
A549_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148097
GTEX-UTHO-0011-R6A-SM-3GIJW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986073
hsa-miR-21	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
amprolium-4241	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
erbb signaling pathway	KEGG Pathways	1.0	null
CRCGN008_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68
BRD-K15609977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22731
Perturb_15163_KD_PGR_SRP097736	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.22748
Monocrotaline_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0510361
JiyoyeP-2003	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51845
iloprost-427	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-NL4W-0011-R5a-SM-2I3GD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.926544
SRRM2	Hub Proteins Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8S8-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer 6 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21207
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81939
Effect of omega 3 PUFA on Huntington 39 s disease pathways	WikiPathways Pathways 2024	1.0	null
BRD-K98427581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09211
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0
15342375-Table3	GeneSigDB Published Gene Signatures	1.0	null
superior parietal lobule, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.877415
GSE148263_6_v_0_trim3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224969,GSE224971_3_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pancreatic cancer	KEGG Pathways 2026	1.0	null
CEBPB_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inhibition	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
pathological	Phosphosite Textmining Biological Term Annotations	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.11468
all	GeneRIF Biological Term Annotations	1.0	null
BRD-K17675924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52837
purine ribonucleoside triphosphate binding	GO Molecular Function Annotations 2015	1.0	null
GSE99687_0_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051691
superficial stratum of r1BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.709
hsa-miR-4662a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.140752
Perturb_14160_KD_IPO11_SRP316321	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.15717
Perturb_536_KO_STAG2_SRP151746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.16236
RS411	CCLE Cell Line Gene Mutation Profiles	1.0	null
positive regulation of map kinase activity	GO Biological Process Annotations 2015	1.0	null
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03025
methotrexate-2041	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Mitogen-activated protein (MAP) kinase, JNK	InterPro Predicted Protein Domain Annotations	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.60477
IFI27L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28276
BRD-K68916730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30964
intermediate stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17318
PMC10675221__F2	PFOCR Pathway Figure Associations 2024	1.0	null
hsa-miR-193a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
ACVR1	Pathway Commons Protein-Protein Interactions	1.0	null
MPP89	CCLE Cell Line Gene CNV Profiles	-1.0	-1.63504
BMPR1A	Pathway Commons Protein-Protein Interactions	1.0	null
KYSE270	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76898
XC-50-TN39_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.32379
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXP1_FOXP1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RNOR-2226-SM-2TF5O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831494
protein phosphorylation	GO Biological Process Annotations 2023	1.0	null
XD-44-FJ34_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313229
GSE135514_8_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
disease of anatomical entity	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
thalidomide-1411	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889604
BRD-K97595801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06079
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.994015
GSE68156_3_v_4_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K76645599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2022
icSARS CoV_72Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.69332
GSK3B_knockdown_206_GDS4305	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.05123
Acute Myeloid Leukemia_LAML_TCGA-AB-2881-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.55435
PMC5528331__F4	PFOCR Pathway Figure Associations 2024	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K66754362	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13386
GSE102505_5_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SK-MEL-28	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE147366_1_v_2_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K96491043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22005
PMC12855817-41698_2025_1249_MOESM1_ESM.pdf-2-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K41853443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.114
mRNA_OTX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Perturb_2990_KO_UTX_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.50898
RNF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28894
COX6B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59364
Huntington Disease	DisGeNET Gene-Disease Associations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5677-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2287_KD_XPO6_SRP245599	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.10762
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.57186
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050728
mesalazine-3584	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
rhythmic process	GO Biological Process Annotations 2015	1.0	null
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.821371
Perturb_15861_KD_ETS1_SRP270313	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Neutropenia	CTD Gene-Disease Associations	1.0	1.34489
NFKBIZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21388
H3K9me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Tucidinostat_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0212338
ambroxol-1623	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Tonic - Clonic Seizures	DisGeNET Gene-Disease Associations	1.0	null
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_-2-1280_genes_are_more_than_four-fold_downregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X4XX-0011-R6B-SM-46MWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00705
Retrosplenial area, ventral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24788
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Cellular responses to stress	Reactome Pathways 2024	1.0	null
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34879
Accessory olfactory bulb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.27387
LS-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3299
OB outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39907
bipolar affective disorder	GWASdb SNP-Phenotype Associations	1.0	0.85593
allosteric	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_CUDC-101_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0108072
GSE138001_0_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Minor Salivary Gland	GTEx Tissue Gene Expression Profiles 2023	1.0	1.01112
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_2374_KO_ASXL1_SRP305063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.35075
BA-90-AA10_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234224
BRD-K32727528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5703
Perturb_15347_KD_SMARCD1_SRP269169	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.98632
GSE63048_11_v_12_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22659
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52273
nucleus	GO Cellular Component Annotations 2023	1.0	null
GSE224969,GSE224971_0_v_5_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
u698	HPA Cell Line Gene Expression Profiles	-1.0	-0.894171
MCF7_Abexinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01644
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
external part of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40831
SP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.952073
GSE160765_2_v_1_twist1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SOX2-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
Orlistat_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.023502
frontalcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.978969
Fc epsilon receptor (FCERI) signaling	Reactome Pathways 2014	1.0	null
Pancreatic Neoplasms	CTD Gene-Disease Associations	1.0	1.86375
Heart Failure	CTD Gene-Disease Associations	1.0	1.33257
POU2F2	JASPAR Predicted Transcription Factor Targets	1.0	null
RAC1	Pathway Commons Protein-Protein Interactions	1.0	null
HOMEZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04618
PMC8144624-41598_2021_90212_MOESM7_ESM.xlsx-apla04620_TLR_LPS-Gene_ID_KEGG_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K44007425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28023
CDKN1B	Pathway Commons Protein-Protein Interactions	1.0	null
PA-TU-8902	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31646
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.7874
hsa-miR-550a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
protein phosphorylation	GO Biological Process Annotations 2015	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE126345_4_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_73_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
adipocytokine signaling pathway	KEGG Pathways	1.0	null
sublayer 6b of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.8877
Myocardial Infarction	CTD Gene-Disease Associations	1.0	1.4933
ddomain	GeneRIF Biological Term Annotations	1.0	null
BRD-K64602559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04498
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.764515
purine ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
Paraflocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26282
BRD-K96379403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1815
Necroptosis	KEGG Pathways 2026	1.0	null
second (ventral) preoptic domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00893
MCF7_Mocetinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00927239
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20333
abnormal cell death	MGI Mouse Phenotype Associations 2023	1.0	null
BHLHE23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52663
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC2839261__F1	PFOCR Pathway Figure Associations 2023	1.0	null
hsa-miR-4526	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
PMC12187926-41421_2025_809_MOESM8_ESM.xlsx-w_SRPK2-KD-kinase_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_15469_KD_KLF5_SRP256723	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.74543
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GCH1	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44O-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06052
CTCF	ENCODE Transcription Factor Targets	1.0	null
EP300_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K14087001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12269
SRC	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH1993	DepMap CRISPR Gene Dependency	1.0	7.41149
vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.266757
PRKCZ	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal behavior	MPO Gene-Phenotype Associations	1.0	null
lovastatin-2854	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.80726
GSE168918_1_v_0_tmprss4_human	RummaGEO Gene Perturbation Signatures	1.0	null
TNF signaling pathway	KEGG Pathways 2026	1.0	null
Neurological pain disorder_CNS - Spinal Cord (MMHCC)_GSE18803	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.758222
Perturb_14886_KO_H13_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.75272
Perturb_15109_KD_MPP8_SRP218207	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.944
Lactate (calcium)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0261145
Schizophrenia_CNS - Brain - Cerebellum (MMHCC)_GSE4036	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.46013
CHD7	ENCODE Transcription Factor Targets	1.0	null
Cytoskeleton organization and intracellular signaling	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.43325
viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044622
artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.238706
Regulatory circuits of STAT3 signaling	WikiPathways Pathways 2024	1.0	null
TRAF6	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A3KG-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73922
MCF7_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0221991
PMC9498168__F6a	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1364
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
cytoplasmic membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.05234
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60265
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20484
Acetylcysteine	CTD Gene-Chemical Interactions	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_53_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10917207-Data_Sheet_1.pdf-6-LMX1B_LMX1B	Rummagene Transcription Factor Associations 2026	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
adult liver stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.405555
behavior/neurological phenotype	MPO Gene-Phenotype Associations	1.0	null
BRD-K49584663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42322
jnk1beta1	GeneRIF Biological Term Annotations	1.0	null
Complete Trisomy 21 Syndrome	DisGeNET Gene-Disease Associations	1.0	null
Perturb_16445_KO_MITF_SRP298756	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.62639
GTEX-R3RS-0526-SM-3GADG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.996403
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.934827
GTEX-PWO3-0926-SM-2I5EY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08268
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MU-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8431385__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GSE226249_0_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839574
Cervical Cancer	DisGeNET Gene-Disease Associations	1.0	null
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
docking	GeneRIF Biological Term Annotations	1.0	null
sirolimus-987	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
components	GeneRIF Biological Term Annotations	1.0	null
PMC6219086__F6	PFOCR Pathway Figure Associations 2024	1.0	null
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.72322
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Anisomycin	CTD Gene-Chemical Interactions	1.0	null
AG 1879	CTD Gene-Chemical Interactions	1.0	null
TRIF (TICAM1)-mediated TLR4 signaling	Reactome Pathways 2024	1.0	null
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RBBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67816
PMC11596949-medi-103-e40529-s002.xlsx-final_targets-PGR_PGR	Rummagene Transcription Factor Associations 2026	1.0	null
nadide-5873	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4520a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
NCIH2106	CCLE Cell Line Gene Expression Profiles	-1.0	-2.69273
CLC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0053355
DEDD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00122
Perturb_676_KO_SLC15A4_SRP212091	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.46873
MCF7_Bosutinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011626
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053643
BRD-K04695993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20211
Perturb_16953_KO_MLX_SRP183152	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.23044
orofacial cleft	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.134895
BRD-A16313205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10553
CLPP_KO_GDS4791_375_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE121824,GSE121826_0_v_3_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
innate immune response	GO Biological Process Annotations 2015	1.0	null
MAP2K2	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_8805_KD_PTB_SRP069229	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.27686
Ovarian Epithelial Cancer	DisGeNET Gene-Disease Associations	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33486
ARHGAP24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00629877
Perturb_14193_KO_PRMT5_SRP149386	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.83149
BRD-K51448234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16949
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.39086
GTEX-WWYW-0011-R8A-SM-3NB3S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875322
MCF7_MLN8054_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137035
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916617
A549_Epothilone A_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0101836
ATM_knockout_16_GDS1544	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.58747
hsa-miR-593	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
ethanol_rattus norvegicus_gpl341_gse1996	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40962
Perturb_10004_KD_KRR1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.66645
positive regulation of defense response	GO Biological Process Annotations 2015	1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.260538
GSE135030_11_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
fluoxetine_mus musculus_gpl1261_gse35763	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal motor capabilities/coordination/movement	MPO Gene-Phenotype Associations	1.0	null
BRD-K90429860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63386
BRD-K86330848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29794
Verapamil_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0431205
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17316
individual	GeneRIF Biological Term Annotations	1.0	null
MAPK Signaling Pathway(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
PMC4259415-oncotarget-05-10198-s002.xlsx-Sheet1-STAT3_Pathway_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE175787_8_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
pirenperone-2455	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.53329
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62084
ioversol-6726	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
localization	GeneRIF Biological Term Annotations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FB-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.084668
EIF2AK1	Pathway Commons Protein-Protein Interactions	1.0	null
regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
regulation of defense response	GO Biological Process Annotations 2015	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N6-A4VF-01A-31R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
facilitating	GeneRIF Biological Term Annotations	1.0	null
SORAFENIB	DGIdb Drug Targets 2026	1.0	0.0203585
GSE205163,GSE205164_2_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
hepatocellular	GeneRIF Biological Term Annotations	1.0	null
retromammillary area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13374
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POU3F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23367
trihexyphenidyl-4133	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7610-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.72758
PSMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27612
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Perturb_10181_KD_CTCF_SRP225887	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.26406
Lung squamous cell carcinoma_LUSC_TCGA-56-A5DS-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K84836394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20842
chlorcyclizine-3893	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7839-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urinary bladder cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.103888
PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_DOWNREGULATED_IN_ERGhigh_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
novobiocin-342	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
medullary collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.241132
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45327
Ras signaling	WikiPathways Pathways 2024	1.0	null
positive regulation of phosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
CLPP_KO_GSE40207_394_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A6EG-06A-12R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168557
CW2	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE143782_6_v_5_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
loop	GeneRIF Biological Term Annotations	1.0	null
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K61660466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89329
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4837
MCF7_Filgotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013552
positive regulation of biological process	GO Biological Process Annotations 2015	1.0	null
Perturb_15097_KD_RELA_SRP372154	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.78936
GSE130246_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.20032
CRCGN017_MCF10A.WT.HP_24H:N23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1895
all	GWASdb SNP-Phenotype Associations	1.0	0.080275
polymorphonuclear leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.1142
positive regulation of protein modification process	GO Biological Process Annotations 2015	1.0	null
Thalamus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.28089
BRD-K36544054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61057
BRD-K41410736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58182
Perturb_9632_KD_CHD8_SRP047233	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.05846
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PKN3	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5B-Up_H3K4me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRN-0011-R5A-SM-2I5EF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839453
BRD-K46124507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6279
Adrenocortical carcinoma_ACC_TCGA-OR-A5J5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Asthma	dbGAP Gene-Trait Associations	1.0	0.060188
TEC	Pathway Commons Protein-Protein Interactions	1.0	null
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
hsa-miR-3154	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
MCF7_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136067
BRD-K83553001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72594
GSE211126_1_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8566230-41388_2021_2018_MOESM3_ESM.xlsx-Cluster2_witn_MYCN_DEGs-Gene_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K90951880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03293
TBK1	Pathway Commons Protein-Protein Interactions	1.0	null
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K17020860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12292
ethaverine-3375	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825526
SNU81	CCLE Cell Line Gene Mutation Profiles	1.0	null
vanadates	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K81124412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10326
leukocyte disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.253127
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Toll-like receptor signaling pathway(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.292613
Trametinib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0440331
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52273
SHP77	CCLE Cell Line Gene CNV Profiles	1.0	2.04288
PRICKLE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45071
PMC3461241__F3	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K32021110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12689
BRD-K34456337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09971
Measles	KEGG Pathways 2026	1.0	null
AGS	CCLE Cell Line Gene Mutation Profiles	1.0	null
cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.700671
PMC8465440__F2	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K24614157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51397
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.329289
PMC6137108__F4	PFOCR Pathway Figure Associations 2024	1.0	null
GSE210580_4_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9382
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60437
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.943671
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11902
GTEX-N7MT-0011-R5a-SM-2I3G6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952345
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
Myocardial Ischemia	CTD Gene-Disease Associations	1.0	1.37504
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Peripheral Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.13075
PMC5986469__F7	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36889
regulation of transcription, dna-templated	GO Biological Process Annotations 2015	1.0	null
GSE102505_6_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-N7MT-0011-R6a-SM-2I3G3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961903
glycocholic acid-2454	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2985
MCF7_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160027
Prestwick-920-3118	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC7773934-Table_1.XLSX-Table_S2-Supplementary_Table_2_TBX22_co-expressed_genes_detailed_results_TBX22	Rummagene Transcription Factor Associations 2026	1.0	null
SH4	CCLE Cell Line Gene Mutation Profiles	1.0	null
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
PMC9387164-Table_2.XLSX-Sheet1-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
BT474	CCLE Cell Line Gene Mutation Profiles	1.0	null
PMC12187926-41421_2025_809_MOESM8_ESM.xlsx-x_LPS-BMDCs-kinase_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hirschsprung Disease	DisGeNET Gene-Disease Associations	1.0	null
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15827
EPHA7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K65137277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04408
Epileptic encephalopathy	ClinVar Gene-Phenotype Associations 2025	1.0	null
TM31	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46782
PMC4387713-supp_gad.255984.114_Table_S3.xlsx-S3B-Up_Dpy30_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
smoothmuscle_8b	HPA Tissue Sample Gene Expression Profiles	1.0	1.0019
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.39908
RBBP5	ENCODE Transcription Factor Targets	1.0	null
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.68581
mantle zone of r10BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20776
Perturb_9169_KO_PCK2_ERP116055	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.37243
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_72_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXC2_FOXC2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71384
positive regulation of intracellular signal transduction	GO Biological Process Annotations 2015	1.0	null
OB glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19405
Perturb_2296_OE_PTEN_SRP175252	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.37152
structural	GeneRIF Biological Term Annotations	1.0	null
GTEX-TSE9-0011-R11A-SM-3DB7N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881873
hsa-miR-1279	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
FOXO4	Pathway Commons Protein-Protein Interactions	1.0	null
scaffold	GeneRIF Biological Term Annotations	1.0	null
GTEX-NFK9-0008-SM-4E3JE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877443
GTEX-T5JC-0011-R4A-SM-32PLT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13603
MCL1	Pathway Commons Protein-Protein Interactions	1.0	null
20174566-TableS1	GeneSigDB Published Gene Signatures	1.0	null
KM12	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.15926
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02314
PRKAA1	Pathway Commons Protein-Protein Interactions	1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.11502
Perturb_2315_KD_MED9_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.64565
GATA3_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUN kinase activity	GO Molecular Function Annotations 2023	1.0	null
HB-95-ZG66_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212575
phosphorylation	GO Biological Process Annotations 2015	1.0	null
PMC5483589__F5	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-NPJ7-2826-SM-2I3FU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833141
GTEX-P44H-0011-R5A-SM-2XCEX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975566
BRD-K21819164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75716
Essential Thrombocytemia_Thrombocyte_GSE2006	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.40166
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5462
TAL1-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-29a	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
Obesity	DisGeNET Gene-Disease Associations	1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Oligo_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RIG-I-like receptor signaling pathway	KEGG Pathways 2026	1.0	null
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.972772
GSE202284,GSE202289_7_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POU3F2	ChEA Transcription Factor Targets	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.23084
PPP2CA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04818
CMPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.948743
19621087-Table1e	GeneSigDB Published Gene Signatures	1.0	null
COG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60949
Cerebral Infarction	DisGeNET Gene-Disease Associations	1.0	null
parasubiculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08102
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5878-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7694-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-130b	TargetScan Predicted Conserved microRNA Targets	1.0	0.241055
sap kinase activity	GO Molecular Function Annotations 2015	1.0	null
Posterolateral visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.94307
BRD-K68143200_NSC 95397_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.85564
GTEX-TSE9-0011-R10A-SM-3DB7O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41377
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054956
JUN kinase activity	GO Molecular Function Annotations 2025	1.0	null
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	111.868
BRD-K79997957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98525
MCF7_PHA-680632_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00965741
Apoptosis Modulation by HSP70(Mus musculus)	WikiPathways Pathways 2014	1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.79202
focuses	GeneRIF Biological Term Annotations	1.0	null
EIF3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56231
MAP3K2	Pathway Commons Protein-Protein Interactions	1.0	null
BHY	CCLE Cell Line Gene CNV Profiles	-1.0	-2.3514
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAPK cascade	WikiPathways Pathways 2024	1.0	null
Primary somatosensory area, upper limb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16489
MAP3K7_knockout_246_GSE34417	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.24706
lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.049887
EIF2AK4	Pathway Commons Protein-Protein Interactions	1.0	null
PMC2783859__F3a	PFOCR Pathway Figure Associations 2023	1.0	null
IRF1	ChEA Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5378
Perturb_8628_KO_Pyk2_SRP329328	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.73482
PMC5054603__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02807
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Ramelteon_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150527
hypertension	GWASdb SNP-Phenotype Associations	1.0	0.768197
arrestins	GeneRIF Biological Term Annotations	1.0	null
PMC4380073__F2	PFOCR Pathway Figure Associations 2023	1.0	null
procyclidine-4233	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SORT1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE166315_2_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MKK4-ARRB2-JNK3 complex	CORUM Protein Complexes	1.0	null
isoconazole-1372	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
domains	GeneRIF Biological Term Annotations	1.0	null
Perturb_9570_KD_CDH11_SRP318732	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.64668
GSE88819_3_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nobox_18509161_newborn_ovary_lof_mouse_gpl1261_gds3254	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.468612
BRD-K96817767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72317
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0137
PMC8818874__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Weight Gain	CTD Gene-Disease Associations	1.0	1.42967
rats-sprague-dawley	Phosphosite Textmining Biological Term Annotations	1.0	null
VAMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29596
alar part of terminal hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09335
BRD-K53547009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09674
JUN	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8431385__F2	PFOCR Pathway Figure Associations 2024	1.0	null
lateral part of MM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58751
CRCGN017_MCF10A.WT.HP_24H:F10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07815
PMC7056823-Table_1.docx-0-HNF1B_HNF1B	Rummagene Transcription Factor Associations 2026	1.0	null
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.445
GTEX-P44H-0011-R10A-SM-2XCEK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32555
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01733
Perturb_9956_KD_SFPQ_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.40785
PMC6923165__F3	PFOCR Pathway Figure Associations 2023	1.0	null
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.586061
dominantnegative	GeneRIF Biological Term Annotations	1.0	null
pyelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.278297
NCIH596	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33884
GSE156923_2_v_3_rbmx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147056_0_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3317-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FoxO signaling pathway	KEGG Pathways 2026	1.0	null
MCF7_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105906
abnormal respiratory system morphology	GWASdb SNP-Phenotype Associations	1.0	0.337746
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K34524418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.6119
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Tanespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.024733
Perturb_7575_KO_SF3B1_SRP342911	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.32854
GSE135514_8_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UBC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1324
GTEX-RU72-0011-R8A-SM-2TF61	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04334
A2780	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41628
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-AAVH-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stress-activated protein kinase signaling cascade	GO Biological Process Annotations 2015	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03915
Lung adenocarcinoma_LUAD_TCGA-55-7914-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
granulocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.04533
chromophobe	GeneRIF Biological Term Annotations	1.0	null
gallamine triethiodide-5735	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Fetal Death	CTD Gene-Disease Associations	1.0	1.4332
testis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074985
Cochlear nucleus, subpedunclular granular region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06175
BRD-K86855109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09318
Adipocytokine signaling pathway	KEGG Pathways 2026	1.0	null
response to abiotic stimulus	GO Biological Process Annotations 2015	1.0	null
proapoptotic	GeneRIF Biological Term Annotations	1.0	null
paclitaxel	Phosphosite Textmining Biological Term Annotations	1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	2.29962
chromium hexavalent ion	CTD Gene-Chemical Interactions	1.0	null
BRD-K85513337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88088
GATA2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CAPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29865
BRD-K84348716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93611
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52273
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846631
BRD-K80233876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3934
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219823
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A7D0-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Alpelisib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00962909
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03713632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0278
Toll-Like Receptors Cascades	Reactome Pathways 2014	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5699-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-3732-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Triamcinolone_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0382015
navicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2256
Optic Nerve Diseases	CTD Gene-Disease Associations	1.0	1.2208
Apoptosis	WikiPathways Pathways 2024	1.0	null
MCF7_IOX2_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175928
map-kinase-signaling-system	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE151090_0_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UPCISCC200	DepMap CRISPR Gene Dependency	1.0	2.0293
IZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3758
Lung squamous cell carcinoma_LUSC_TCGA-98-A53J-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDC42	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_9637_KO_CHCHD2_SRP212876	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.53519
GSE160083,GSE160084_1_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29N-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11960_KD_RAD6B_SRP258673	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.91578
Respiratory Function Tests	DisGeNET Gene-Phenotype Associations	1.0	null
Perturb_16510_OE_Tafazzin_SRP284254	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Pleural Effusion	CTD Gene-Disease Associations	1.0	1.09226
MOLM6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.52279
GTEX-RNOR-2326-SM-2TF4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5608
TOZASERTIB	DGIdb Drug Targets 2026	1.0	0.0145418
MEK INHIBITOR PD-98059	DGIdb Drug Targets 2026	1.0	0.138808
MCF7_CEP-33779_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113494
Piroxicam_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0300312
BRD-K69564473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26592
IFNGR1	Pathway Commons Protein-Protein Interactions	1.0	null
OVK18	CCLE Cell Line Gene Mutation Profiles	1.0	null
Huntington disease	KEGG Pathways 2026	1.0	null
PMC4459818-emmm0007-0788-sd2.xls-Table_S2-Table_S2_P_values_of_Figure_1_Differential_expression_of_UPR_genes_in_AR_high_AR_medium_and_AR_low_samples_from_TCGA_provisional_prostate_cancer_cohort_AR	Rummagene Transcription Factor Associations 2026	1.0	null
aminophylline-3036	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
testicular cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.133373
GSE149355_0_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.068472
posteroventral (inferior) parietal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.937375
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216238,GSE216241_0_v_1_tonsl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.225976
Anteromedial visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.87231
Fc epsilon receptor (FCERI) signaling	Reactome Pathways 2024	1.0	null
GTEX-POYW-0526-SM-2XCEY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73056
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J6-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
creb1_22108299_heart_left_ventricle_lof_mouse_gpl1261_gds3660	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.436094
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.58741
GSE217115_2_v_0_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A07870296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98651
Perturb_14286_OE_YAPS94A_SRP336792	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BRD-K36111748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83098
posteromedial visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.25438
cytoplasmic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.051853
Liver Regeneration Disorder	DisGeNET Gene-Phenotype Associations	1.0	null
TAK-901_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.013293
MAX_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DB	GDSC Cell Line Gene Expression Profiles	1.0	2.7706
cell-line-tumor	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hearing Loss	CTD Gene-Disease Associations	1.0	1.14268
PMC3164671__F5	PFOCR Pathway Figure Associations 2023	1.0	null
PMC6219086__F5	PFOCR Pathway Figure Associations 2023	1.0	null
amygdaloid complex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51228
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41542
hl60	HPA Cell Line Gene Expression Profiles	-1.0	-0.894171
abnormal somatic motor system morphology	MGI Mouse Phenotype Associations 2023	1.0	null
Perturb_12029_OE_ID4_SRP333901	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.72788
GTEX-QVUS-0011-R3A-SM-3GAFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75953
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.41239
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061453
PMC11236317-aging-16-205930-s001.pdf-1-CREM_CREM	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7806950-mmc3.xlsx-Sheet2-Table_S3_Comparison_of_DEGs_following_targeting_of_dSaCas9-repressors_to_DUX4_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
tretinoin-1548	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Sarcoma_SARC_TCGA-DX-A3U9-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN011_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8846
phosphatase1	GeneRIF Biological Term Annotations	1.0	null
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.897766
embryonic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.096467
orbital frontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.36798
MCF7_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012135
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.47328
cerebralcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.849162
GSE261563_5_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC	ChEA Transcription Factor Targets	1.0	null
19377508-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
Perturb_9908_KD_GRSF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.50605
HOXB9_02_15	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	5.90689
integrin alpha11-beta1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.10256
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_132_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
their	GeneRIF Biological Term Annotations	1.0	null
SIROLIMUS	DGIdb Drug Targets 2026	1.0	0.0357166
LIVF001-009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78069
OCILY10	CCLE Cell Line Gene Expression Profiles	1.0	2.13944
cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.169812
A549_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145366
FOXA2	ChEA Transcription Factor Targets	1.0	null
LIVF001-028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69361
MCF7_ENMD-2076 L-Tartaric acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146188
17555561-Table2	GeneSigDB Published Gene Signatures	1.0	null
icSARA deltaORF6_30Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.53982
Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.522185
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
PPP1R2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16754
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
psychotic disorder	GWASdb SNP-Disease Associations	1.0	0.275076
Ipatasertib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0363823
GTEX-T6MN-0011-R2A-SM-32QOW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974649
GTEX-UJHI-0006-SM-3DB8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05013
BRD-K97938633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88874
KYSE-410	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE185519_4_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Foxf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.9259
MCF7_Givinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00993017
NCIH1105	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68268
15705876-TableS6	GeneSigDB Published Gene Signatures	1.0	null
Perturb_9108_KD_STAT3_SRP363695	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.7383
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08852
GTEX-Q2AG-0011-R6A-SM-2HML7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958005
SKOV3	CCLE Cell Line Gene CNV Profiles	1.0	1.55825
unique	GeneRIF Biological Term Annotations	1.0	null
Verteporfin_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0285759
decreased susceptibility to dopaminergic neuron neurotoxicity	MPO Gene-Phenotype Associations	1.0	null
hsa-miR-4478	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
GSE151612_0_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.51295
Central Neuroblastoma	DisGeNET Gene-Disease Associations	1.0	null
Perturb_5436_KO_Rspo3_SRP363653	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.6616
alverine-2273	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SKNFI	CCLE Cell Line Gene CNV Profiles	1.0	1.46819
chlorambucil-4345	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_12168_OE_ZEB1_SRP178052	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.61084
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79079
BRD-K50924315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30119
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67049
GSE133087_5_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223008_9_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FAM169A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27596
posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.945306
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IR-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Central Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.08584
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Peroxiredoxin 2 induced ovarian failure	WikiPathways Pathways 2024	1.0	null
NCIH1838	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49877
nucleus sagulum, deep part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18176
map	GeneRIF Biological Term Annotations	1.0	null
Intestinal Diseases	CTD Gene-Disease Associations	1.0	1.32074
layer 2 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04287
SMAD3	ChEA Transcription Factor Targets	1.0	null
PMC6073502__F1	PFOCR Pathway Figure Associations 2024	1.0	null
hsa-miR-3119	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
ZNF549	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26458
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_PSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
regulate	GeneRIF Biological Term Annotations	1.0	null
clopidol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53117
EPINEPHRINE	DGIdb Drug Targets 2026	1.0	0.0656724
Perturb_17802_KO_ZNF675_SRP305529	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.56967
abnormal erythrocyte morphology	MPO Gene-Phenotype Associations	1.0	null
primary motor cortex (area M1, area 4)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.62429
PMC4450280__F6	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-WZTO-0011-R1B-SM-3NMAR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985743
Perturb_291_KO_CD274_SRP365183	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.4865
dirithromycin-2863	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SLC7A8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04563
17660535-TableS4c	GeneSigDB Published Gene Signatures	1.0	null
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:G17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0303
Lennox-Gastaut Syndrome	DisGeNET Gene-Disease Associations	1.0	null
EFO27	CCLE Cell Line Gene Mutation Profiles	1.0	null
A549_G007-LK_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259772
PMC5483589__F5	PFOCR Pathway Figure Associations 2024	1.0	null
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58467
Cobalt levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
NCIH1930	CCLE Cell Line Gene Mutation Profiles	1.0	null
Perturb_13518_KD_ILF2_SRP077068	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.53155
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.851416
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91796
kinase activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K88679751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06739
17660535-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
rosiglitazone_mus musculus_gpl1261_control_gds4036	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JUN-21703547-K562-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-X8HC-0526-SM-4E3JA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05909
PMC10528072-NIHMS1928302-supplement-5.xlsx-ASCL1-target_genes-ABAT_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
immune	GAD High Level Gene-Disease Associations	1.0	0.293278
response to radiation	GO Biological Process Annotations 2015	1.0	null
BRD-K17743313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29698
BRD-K82446079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1564
VMRCRCW	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34805
neuronal	GeneRIF Biological Term Annotations	1.0	null
GSE216540_10_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
olfactory lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085697
RH-1	GDSC Cell Line Gene Expression Profiles	1.0	1.69718
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.81346
LTBR_INHIBITION - 3 Days_GDS2005_730_mouse_Lymph nodes  (MG-430B)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-QVJO-0011-R5A-SM-2S1QM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0055
H3K4me1_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TCF21-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-4742-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.099701
Lung adenocarcinoma_LUAD_TCGA-97-8552-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hypertension	CTD Gene-Disease Associations	1.0	1.79101
Dicumarol	CTD Gene-Chemical Interactions	1.0	null
BRD-A43575461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47324
altered	GeneRIF Biological Term Annotations	1.0	null
HOXA5	JASPAR Predicted Transcription Factor Targets	1.0	null
reduced	GeneRIF Biological Term Annotations	1.0	null
GATA3	JASPAR Predicted Transcription Factor Targets	1.0	null
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	1.0	2.97079
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15091
Perturb_6414_KO_TP53_SRP274402	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.33121
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5982-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12575
Myocardial Ischemia	DisGeNET Gene-Disease Associations	1.0	null
15452549-Table1	GeneSigDB Published Gene Signatures	1.0	null
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.140209
jnk3alpha2	GeneRIF Biological Term Annotations	1.0	null
NCI-H1563	GDSC Cell Line Gene Expression Profiles	-1.0	-2.0903
PMC7783806__F8	PFOCR Pathway Figure Associations 2023	1.0	null
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
translocation	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46579
BRD-K38240683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26318
Bradycardia	CTD Gene-Disease Associations	1.0	1.04276
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.174936
ventrolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11775
GSE147056_2_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-X261-0011-R8A-SM-4E3I5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921756
GSE261563_6_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Autophagy - animal	KEGG Pathways 2026	1.0	null
ATORVASTATIN CALCIUM TRIHYDRATE	DGIdb Drug Targets 2026	1.0	0.0925384
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52273
abnormal hematopoiesis	MPO Gene-Phenotype Associations	1.0	null
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889604
neostriatum	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K13086002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86866
GTEX-TSE9-2926-SM-3DB77	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83851
hsa-miR-1283	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
Perturb_14055_OE_NFIB_SRP281947	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.86591
GSE93674_1_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-0_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.991803
NCIH1048	CCLE Cell Line Gene CNV Profiles	1.0	2.37405
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.55182
PRPS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00472698
pulmonary artery endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.195312
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3387-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TSE9-3026-SM-3DB76	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70774
MCM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00419357
hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.056173
Perturb_7879_KD_EXOSC3_SRP266190	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.97594
positive regulation of phosphorylation	GO Biological Process Annotations 2015	1.0	null
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303997
PMC6962646-mmc2.xlsx-StemCell_Genesets_2018-HMGA1_HMGA1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831302
MMP13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.003365
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.063156
Dexamethasone_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0398343
posteroventral (inferior) parietal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.61985
PMC7096153__F2	PFOCR Pathway Figure Associations 2024	1.0	null
cjun	GeneRIF Biological Term Annotations	1.0	null
SF295	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.11818
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.03768
BRD-K34701680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09233
BRD-K69659917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03601
regulation of kinase activity	GO Biological Process Annotations 2015	1.0	null
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08207
pyrithyldione-3482	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
urinary bladder cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.230382
r9 portion of the hypoglossal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13183
IZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.983417
GSE235605,GSE235701_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.40709
GATA3-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K54881917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1625
MYC-19915707-AK7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Fc receptor signaling pathway	GO Biological Process Annotations 2023	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NC-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_55_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.74653
intermediate stratum of r10BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10842
GTEX-NL4W-0011-R4a-SM-2I5GZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02203
MCF7_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241678
Perturb_4759_KO_DLG2_SRP315088	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.6011
4EGI-1_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0283264
intermediate stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44715
5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide	DrugBank Drug Targets	1.0	null
Glycyrrhizic acid_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0250336
GSE128634,GSE128636_2_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
lateral tuberal nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4021
BRD-K63997411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37202
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_337_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	1.0	1.43209
GSE242290_3_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
XRK3F2_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0284082
clofazimine-3239	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mantle zone of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07084
hsa-miR-3617	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967095
Oxidative stress response	WikiPathways Pathways 2024	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897037
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.928391
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.50109
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
Hydroxyurea_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0498078
Lipoic acid_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0281133
MCF7_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133329
BRIMAPITIDE, C-TERMINAL ACID	DGIdb Drug Targets 2026	1.0	1.01792
NOD-like receptor signaling pathway	KEGG Pathways 2026	1.0	null
Primary visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82746
pyrantel-2260	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
(+/-)-catechin-3351	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Simotinib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0428475
homosalate-3879	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAPK9	Pathway Commons Protein-Protein Interactions	1.0	null
PMC5868815__F3	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851986
Disorders of Sex Development	CTD Gene-Disease Associations	1.0	1.12288
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_up-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SW48	GDSC Cell Line Gene Expression Profiles	-1.0	-1.50746
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K84391462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44589
Magnesium	HMDB Metabolites of Enzymes	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.549773
immunologic hypersensitivity	GWASdb SNP-Phenotype Associations	1.0	0.292345
MCF7_Nintedanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0246407
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_JNJ-7706621_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153715
Keratocystic Odontogenic Tumor	DisGeNET Gene-Disease Associations	1.0	null
infection	GAD High Level Gene-Disease Associations	1.0	0.293278
adenyl ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
MAP2K4	Pathway Commons Protein-Protein Interactions	1.0	null
SW1271	CCLE Cell Line Gene Mutation Profiles	1.0	null
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.8072
GTEX-XXEK-0926-SM-4BRWH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10416
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6225-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210885_5_v_6_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Tuberculosis	KEGG Pathways 2026	1.0	null
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Ensembl_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
hsf1_00000000_tcell_lof_mouse_gpl1261_gse41005	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.489753
GTEX-OXRN-0011-R10A-SM-2I5GC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32798
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.268828
LU-99A	GDSC Cell Line Gene Expression Profiles	-1.0	-2.05662
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.17484
PMC7057487__F3	PFOCR Pathway Figure Associations 2023	1.0	null
MCF7_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157749
PMC7759681__F3	PFOCR Pathway Figure Associations 2023	1.0	null
PMC8944338__F3	PFOCR Pathway Figure Associations 2024	1.0	null
fc-epsilon receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
Perturb_32_OE_ERG/MYC_SRP069177	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.71085
hsa-miR-4666-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.37496
PMC2839261__F1	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K26402831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34239
CRCGN014_HEPG2_3H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0234
Perturb_14966_OE_miR424_SRP341198	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.76041
STAT1_02_23	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.80735
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05816
Lung squamous cell carcinoma_LUSC_TCGA-21-1078-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.WT.HP_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24812
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.094714
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.90533
GTEX-QMR6-0011-R1A-SM-32PKW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884077
hsa-miR-599	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Perturb_12571_KD_YBX1_SRP262465	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.99836
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BICR16	CCLE Cell Line Gene CNV Profiles	1.0	1.39837
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.94377
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
hsa-miR-3160-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SNU1076	DepMap CRISPR Gene Dependency	1.0	2.90278
receptor signaling protein activity	GO Molecular Function Annotations 2015	1.0	null
MCF7_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0100463
Perturb_2332_KD_SNRPE_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.15447
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.944499
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE138863_3_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-3665	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.053776
icSARS CoV_54Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	3.24103
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.935028
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17747
PMC5380511__F7	PFOCR Pathway Figure Associations 2023	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
L33	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7436
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73363
hirschsprung's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.219057
PMC12685885-Table1.xlsx-Table_S9-Du_PanCancer_ATF3_PanFib_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
true	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981808
Cannabinoid receptor signaling	WikiPathways Pathways 2024	1.0	null
SNAPC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5208
MAP3K3	Pathway Commons Protein-Protein Interactions	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.946932
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36124
GSE152050,GSE152052_1_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44317
BRD-K66807670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08492
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MYCN_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
FOXM1-26456572-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
myd88-dependent toll-like receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
layer 4 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02044
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73697
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
SNU-601	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46056
BRD-K82056353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53996
positive regulation of innate immune response	GO Biological Process Annotations 2015	1.0	null
BRD-K76125116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56353
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.38668
PMC7848718__F4	PFOCR Pathway Figure Associations 2024	1.0	null
Wnt signaling pathway	KEGG Pathways 2026	1.0	null
PAK2	Pathway Commons Protein-Protein Interactions	1.0	null
bpaec cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.516891
PU.1	MotifMap Predicted Transcription Factor Targets	1.0	null
hsa-miR-3622b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Perturb_6425_KD_LOC646329_SRP220725	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.60236
phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.962903
GTEX-WWYW-0011-R5A-SM-3NB3E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852324
MCF7_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135107
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C20orf96	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2324
Sodium Salicylate_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0662006
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052859
Regorafenib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0197346
abnormality of nervous system morphology	GWASdb SNP-Phenotype Associations	1.0	0.064632
estradiol_mus musculus_gpl4134_gse23072	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.855885
tiaprofenic acid-4171	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EC-01-PH79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242737
GSE135439_0_v_1_pax5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Peripheral artery disease	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046587
growth cone	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.276304
BRD-K90311252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24115
MCF7_Givinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00603166
Perturb_262_KO_CD274_SRP365183	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.95092
toll-like receptor tlr6:tlr2 signaling pathway	GO Biological Process Annotations 2015	1.0	null
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.7652
BRD-K30860517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10115
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52273
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K22701871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10602
KHDRBS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05356
stress	Phosphosite Textmining Biological Term Annotations	1.0	null
SNU324	CCLE Cell Line Gene Mutation Profiles	1.0	null
inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.223853
MAP kinase activity	GO Molecular Function Annotations 2025	1.0	null
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52273
Piriform-amygdalar area, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2344
periventricular stratum of r5Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2752
HEC265	CCLE Cell Line Gene Mutation Profiles	1.0	null
BRD-A09975616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01823
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
pifithrin	CTD Gene-Chemical Interactions	1.0	null
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899866
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7414-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
PMC10082806-42003_2023_4756_MOESM4_ESM.xlsx-AML2_RelvsTum_DMRs_anno-annot_symbol_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
SMAD3-21741376-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TNK2	Pathway Commons Protein-Protein Interactions	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	2.35011
BRD-K34274486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96764
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
APOD_KO_GDS3913_487_mouse_Cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
schizophrenia	GWASdb SNP-Disease Associations	1.0	0.652472
Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057096
liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.083011
COLO679	DepMap CRISPR Gene Dependency	1.0	5.43761
GSE189653,GSE203344_5_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.762488
MCF7_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00788112
hsa-miR-590-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
pelvic inflammatory disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.484744
estradiol-5905	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-51-4080-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.8877
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
JAK1	Pathway Commons Protein-Protein Interactions	1.0	null
RCOR1-19997604-NEURONS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
0173570-0000-4715	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014539
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_6_MRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
glucose	Phosphosite Textmining Biological Term Annotations	1.0	null
vascular disease	GWASdb SNP-Disease Associations	1.0	0.090197
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.980113
Blindness	CTD Gene-Disease Associations	1.0	1.29225
Lung squamous cell carcinoma_LUSC_TCGA-56-5897-01A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Toll Like Receptor 9 (TLR9) Cascade	Reactome Pathways 2014	1.0	null
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
HCC2279	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50879
possible	GeneRIF Biological Term Annotations	1.0	null
Perturb_2723_KD_HOTAIR_SRP172688	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.0087
cellular_component	GO Cellular Component Annotations 2015	1.0	null
immune response-regulating signaling pathway	GO Biological Process Annotations 2015	1.0	null
MCF7_Resminostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00820307
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.43231
GSE199538,GSE199539_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K82765368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35991
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.01503
peritoneum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23961
PMC8283158-mmc2.xlsx-TCF4_Glut-Gene_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8062-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11426_KD_PRMT1_SRP357238	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.13728
GSE171837_3_v_1_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03209
GTEX-W5X1-0006-SM-3GIJZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36427
SW48_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.97617
Perturb_38_KD_ATRX_SRP308220	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
TMEM268	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12248
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05373
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35644
BRD-K87385385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20334
rac1	Phosphosite Textmining Biological Term Annotations	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.80713
GSE182770,GSE182784_0_v_1_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Roxadustat_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0198122
PMC4411413__SF2	PFOCR Pathway Figure Associations 2023	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-7950-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RIPK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27969
Toll Like Receptor 3 (TLR3) Cascade	Reactome Pathways 2024	1.0	null
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59636
GTEX-X585-3026-SM-46MWF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60355
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.474823
homeostasis/metabolism phenotype	MPO Gene-Phenotype Associations	1.0	null
BRD-K84278600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46971
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_11_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
fulvestrant-5969	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
fasassociated	GeneRIF Biological Term Annotations	1.0	null
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	208.816
Apoptosis(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
GSE121809_1_v_0_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
subthalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.858336
ABL2	Pathway Commons Protein-Protein Interactions	1.0	null
regulation of intracellular signal transduction	GO Biological Process Annotations 2015	1.0	null
BRD-K28467592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70694
Ventral pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.02526
metabolic process	GO Biological Process Annotations 2015	1.0	null
cytokine	Phosphosite Textmining Biological Term Annotations	1.0	null
EC-GI-10	COSMIC Cell Line Gene CNV Profiles	-1.0	-5.12655
1-(3-bromophenyl)-7-chloro-6-methoxy-3,4-dihydroisoquinoline	DrugBank Drug Targets	1.0	null
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858751
MSMO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00523252
GSE90019,GSE90020_5_v_2_phf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60962
Phenylephrine	CTD Gene-Chemical Interactions	1.0	null
PMC7149918-12974_2020_1781_MOESM1_ESM.xlsx-Table_S7_CEBPB_Astrocyte_marker-Ensembl_ID_CEBPB	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238544
BRD-K69387464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59196
GSE205163,GSE205164_1_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
preopto-hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02845
GTEX-S7SE-0011-R6A-SM-2XCD9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911643
GSE182680,GSE182683_10_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-135b	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
Toxoplasmosis	KEGG Pathways 2026	1.0	null
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040029
HSPA8	Hub Proteins Protein-Protein Interactions	1.0	null
camkii	GeneRIF Biological Term Annotations	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
Perturb_9170_KD_CFTR_ERP118933	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.4304
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
MCF7_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149366
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4619-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
jnk2	GeneRIF Biological Term Annotations	1.0	null
MAP4K2	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-216a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
regulation of phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-641	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.31074
CRCGN016_MCF10A.TP53.M_24H:M09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05258
CRCGN008_HEPG2_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1108
Perturb_8998_KD_lnc Cyrano_SRP261325	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.65795
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.2559
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.39001
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.079582
GSE135030_11_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPEG	Pathway Commons Protein-Protein Interactions	1.0	null
mifepristone-3185	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cerebral-cortex	Phosphosite Textmining Biological Term Annotations	1.0	null
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.33995
Perturb_7379_KD_SMG5_ERP122822	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.11171
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159025
BRD-K85513726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1538
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-06A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
alpha	GeneRIF Biological Term Annotations	1.0	null
A549_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161998
Rhabdomyosarcoma	CTD Gene-Disease Associations	1.0	1.09226
CAV3_KO_GDS3533_357_mouse_mammalian glands	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Perturb_12723_KD_ARID4B_SRP152296	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.37896
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.865377
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.714189
lisuride-5028	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal behavioral response to xenobiotic	MPO Gene-Phenotype Associations	1.0	null
GTEX-UTHO-3026-SM-3GAFB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54662
epilepsy syndrome	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
NCI-H1869	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Hepatitis B infection	WikiPathways Pathways 2024	1.0	null
regulation of nucleobase-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-4.10739
Pneumonia	CTD Gene-Disease Associations	1.0	1.4591
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
myeloid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.136389
PKIA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32443
A549_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138822
layer 6b of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.21615
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855041
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-11A-13R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95651150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.82382
GRSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05428
Perturb_7935_KO_VTRNA1_SRP252980	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.46727
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5013636-ncomms12601-s5.xlsx-FREAC2-Groups_FOXF2	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_93_KD_ANXA4_SRP127547	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.60827
CHRNA7	Pathway Commons Protein-Protein Interactions	1.0	null
layer 3 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16896
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.850623
ck2	Phosphosite Textmining Biological Term Annotations	1.0	null
Perturb_12904_KD_FOXA1_SRP313175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.89056
HESPERADIN	DGIdb Drug Targets 2026	1.0	0.0254481
nucleus	GO Cellular Component Annotations 2025	1.0	null
2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One	DrugBank Drug Targets	1.0	null
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12557
GSE211983_1_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K63584084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7101
Posterolateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16896
19074895-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
MDAMB231	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71222
Hemolysis	CTD Gene-Disease Associations	1.0	1.40064
hippocampal	Phosphosite Textmining Biological Term Annotations	1.0	null
morphological abnormality of the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.072158
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.579747
citiolone-3755	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KO-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mood disorder	GWASdb SNP-Disease Associations	1.0	0.462137
hsa-miR-4288	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Cytokine Signaling in Immune system	Reactome Pathways 2024	1.0	null
Cancer pathways	WikiPathways Pathways 2024	1.0	null
arrestins	Phosphosite Textmining Biological Term Annotations	1.0	null
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6405
NUDHL1	CCLE Cell Line Gene CNV Profiles	1.0	1.50462
BRD-K38607769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90919
exendin	GeneRIF Biological Term Annotations	1.0	null
MCF7_AMG-900_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015359
Neratinib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0392072
RLF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08053
GSE121198,GSE129782_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal blood cell morphology/development	MPO Gene-Phenotype Associations	1.0	null
teratocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.150295
hsa-miR-155	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BF-11A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1385	CCLE Cell Line Gene Expression Profiles	1.0	1.55831
PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03408
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6960-01A-41R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13973870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10505
Hyperactive Behavior	DisGeNET Gene-Phenotype Associations	1.0	null
Pertussis	KEGG Pathways 2026	1.0	null
CDK5RAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89486
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
nervous system phenotype	MPO Gene-Phenotype Associations	1.0	null
EGF	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Toll Like Receptor 3 (TLR3) Cascade	Reactome Pathways 2014	1.0	null
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
abnormal nervous system morphology	MPO Gene-Phenotype Associations	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_80_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15474
SP in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20216
BRD-K63547380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40451
PMC11830294-mmc4.xlsx-HSCR-related-ASCL1_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226249_0_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.59056
Alzheimer disease	KEGG Pathways 2026	1.0	null
map kinase kinase activity	GO Molecular Function Annotations 2015	1.0	null
SLC35A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16561
STAT3-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
butylated-hydroxytoluene	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02661
DB	CCLE Cell Line Gene Expression Profiles	1.0	1.96987
Neoplasm Metastasis	CTD Gene-Disease Associations	1.0	1.50524
BRD-A80723361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02546
GSE229309,GSE229314_4_v_1_elavl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K06250424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01056
CD19+_BCells(neg._sel.)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.899778
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-30-XU83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344375
primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.960717
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5691-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2135	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23356
HCC2935	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36748
Perturb_15866_KD_BMI1_ERP013870	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.32575
PMC11003700-pbio.3002240.s013.xlsx-siMYCN_RNA_IMR32_48h_q_0_05_1_5-Table_S6_Genes_commonly_and_differentially_regulated_by_MYCN_and_WDR5_in_IMR32_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139804
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
arrestin	GeneRIF Biological Term Annotations	1.0	null
PMC2593012__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Integrin signalling pathway	PANTHER Pathways	1.0	null
RDX	Pathway Commons Protein-Protein Interactions	1.0	null
SPTAN1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K91467755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04613
MCF7_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154097
felbinac-3398	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02629
MCF7_Luminespib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178411
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U9-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NB6	GDSC Cell Line Gene Expression Profiles	1.0	1.93876
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00605
AKT1_knockdown_43_GSE12291	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.88926
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.833381
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Perturb_3661_KO_EZH2_SRP211748	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.978
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873765
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.250023
Langer-Giedion Syndrome	DisGeNET Gene-Disease Associations	1.0	null
AURKA	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_6830_KO_MTA1_SRP173632	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.9699
BRD-K19327124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58859
receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.058593
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.560312
Perturb_8786_Mut_HNF6_SRP217514	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.56502
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	0.830554
BRAF	Pathway Commons Protein-Protein Interactions	1.0	null
hek-293	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K05127596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51878
BRD-K39318389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29995
remoxipride-3124	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_15557_KO_SLFN11_SRP327912	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.59945
BRD-K89264608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29418
FoxO family signaling	PID Pathways	1.0	null
A549_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149649
GSE210682_2_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
DDR1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN010_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11667
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.10694
IL18BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2053
dorsalstriatum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.04432
membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K87357593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16423
CD14+_Monocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.33271
GTEX-Q2AG-0011-R8A-SM-2HMK5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87919
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15197
JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1	Reactome Pathways 2014	1.0	null
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.14473
cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.578883
N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE	DrugBank Drug Targets	1.0	null
Melatonin	CTD Gene-Chemical Interactions	1.0	null
Thrombocytopenia	CTD Gene-Disease Associations	1.0	1.14885
Oxidative Stress Induced Senescence	Reactome Pathways 2024	1.0	null
nuclear part	GO Cellular Component Annotations 2015	1.0	null
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54182
BRD-K06408981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64734
KYSE450	CCLE Cell Line Gene CNV Profiles	-1.0	-2.80477
BT20	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43418
HEC151	CCLE Cell Line Gene Mutation Profiles	1.0	null
MAGED1	Pathway Commons Protein-Protein Interactions	1.0	null
MHHNB11	CCLE Cell Line Gene Expression Profiles	1.0	1.40812
ANTIESTROGEN	DGIdb Drug Targets 2026	1.0	0.12724
activation of immune response	GO Biological Process Annotations 2015	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.949056
PMC10123531-NIHMS1874945-supplement-Table_S3.xlsx-SOX17_BCAT_cobound_coreg_peaks-Gene_Name_SOX17	Rummagene Transcription Factor Associations 2026	1.0	null
GHSR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00574333
leukopenia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.33651
genistein-703	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pancreatic cancer	KEGG Pathways	1.0	null
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.94377
hsa-miR-3666	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
artery disease	GWASdb SNP-Disease Associations	1.0	0.125352
17894856-SuppList4	GeneSigDB Published Gene Signatures	1.0	null
GSE135030_11_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5986469__F8	PFOCR Pathway Figure Associations 2023	1.0	null
Signaling by Interleukins	Reactome Pathways 2024	1.0	null
hsa-miR-642b	TargetScan Predicted Conserved microRNA Targets	1.0	0.127531
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K35681049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0676
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.0105
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-1.15128
PMC2825767__F1	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-A15454510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54439
Cardiomegaly	CTD Gene-Disease Associations	1.0	1.30881
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69276
regulation of circadian rhythm	GO Biological Process Annotations 2015	1.0	null
hsa-miR-2682	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
Perturb_7956_KD_EXOSC3_SRP222099	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.13105
RBBP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15941
GATA2_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.12085
SP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.455
MKN7	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38672
Perturb_7555_KD_SP1_SRP303813	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.26716
Toll Like Receptor 4 (TLR4) Cascade	Reactome Pathways 2024	1.0	null
Accidental Falls	DisGeNET Gene-Phenotype Associations	1.0	null
HD-28-QL60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231959
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K51237617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32276
JHUEM7	CCLE Cell Line Gene Mutation Profiles	1.0	null
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.79853
COLO-824	GDSC Cell Line Gene Expression Profiles	-1.0	-1.58244
PGBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01546
fc receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
BRD-K80965028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14358
PMC3669416-pone.0064838.s001.xls-mHTT-MECP2_MECP2	Rummagene Transcription Factor Associations 2026	1.0	null
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.69112
Disease Models, Animal	CTD Gene-Disease Associations	1.0	1.443
related	GeneRIF Biological Term Annotations	1.0	null
BRD-K06355852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80315
BRD-A71880598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43305
Captopril_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0373411
SubthalamicNucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.972948
Serine/threonine-protein kinase, active site	InterPro Predicted Protein Domain Annotations	1.0	null
GTEX-REY6-2126-SM-48FD9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824244
Ranolazine_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0250766
A549_Bisindolylmaleimide IX_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138636
PMC12358249-supplementary_table_s5_ioaf064.xlsx-DMRT1_-_vs_WT__4_months-Unnamed_1_DMRT1	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
NCI-H2452	GDSC Cell Line Gene Expression Profiles	-1.0	-2.67641
Spinal Muscular Atrophy, Infantile_CNS - Spinal Cord (MMHCC)_GSE3075	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.92247
Mitogen-activated protein (MAP) kinase, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
Prenatal Injuries	CTD Gene-Disease Associations	1.0	1.71748
SP in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38271
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50118
GTEX-Q2AG-0011-R2A-SM-2HMIT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01907
GRIN2B	Hub Proteins Protein-Protein Interactions	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.03829
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07947
PMC6137108__F4	PFOCR Pathway Figure Associations 2023	1.0	null
PMC5550424-41467_2017_212_MOESM4_ESM.xlsx-Hematlas-Genesets-HMGA1_HMGA1	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.29373
hydroxyzine-6660	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14746
CRCGN011_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1546
orbital frontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02128
BRD-K43834805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02503
BRD-K21927299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.329
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Perturb_7136_KD_SETD8_DRP009168	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.06908
PINGYANGMYCIN	DGIdb Drug Targets 2026	1.0	2.03585
CSNK2A1	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.773174
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_116_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.5488
BRD-K30910725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01471
GTEX-PWO3-0011-R8A-SM-2I5GD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15241
Pseudomonas Infection_Lung Tissue_GSE923	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.35637
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.952035
Memory Disorders	CTD Gene-Disease Associations	1.0	1.92091
GSE183606_1_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47V-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AOB, outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.86577
Primary somatosensory area, barrel field, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.95126
CAL-51	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3664
PMC8335696__F7	PFOCR Pathway Figure Associations 2024	1.0	null
Perturb_8785_KO_HNF6_SRP217514	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.16849
respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04585
12471243-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13881
L428	DepMap CRISPR Gene Dependency	1.0	3.40047
Sarcoma	CTD Gene-Disease Associations	1.0	1.13449
GRIN1	Hub Proteins Protein-Protein Interactions	1.0	null
purine ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
substance-related disorder	GWASdb SNP-Disease Associations	1.0	0.886521
hsa-miR-516b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.897766
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.905985
GTEX-X585-0011-R6A-SM-46MVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860654
bax	Phosphosite Textmining Biological Term Annotations	1.0	null
Perturb_11687_KD_RRM2_SRP212736	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.98073
PMC11903614-11033_2025_10367_MOESM3_ESM.xlsx-Sheet1-Pharmacological_inhibition_of_the_Janus_Kinases_enhances_ASCL1_protein_stability_and_transcriptional_activity_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
Accessory olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92744
abdomen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067544
PMC12254336-41698_2025_947_MOESM1_ESM.docx-5-STAT1-S727_predicted_kinases_Top_30_PhosphoSitePlus_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
immune system process	GO Biological Process Annotations 2015	1.0	null
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898797
GSE100732,GSE100733_0_v_1_lrpprc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
decreased cell death	MPO Gene-Phenotype Associations	1.0	null
Ponatinib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0315392
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.73615
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
anteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06563
postsynaptic	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-7521-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3933
BRD-K55311609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21967
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Perturb_11919_KD_PDPN_SRP071702	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.59613
C2orf15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16517
GSE160442,GSE160444_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XLM4-0011-R4B-SM-4AT5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08359
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A719-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LAMA-84	GDSC Cell Line Gene Expression Profiles	-1.0	-1.4332
BRD-K32862383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.81957
PMC11092636__F3	PFOCR Pathway Figure Associations 2024	1.0	null
PMC6028720__F3	PFOCR Pathway Figure Associations 2023	1.0	null
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOXD13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82436
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Postoperative Complications	CTD Gene-Disease Associations	1.0	1.07625
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.52413
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P7-A5NY-05A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.836062
GTEX-UTHO-0011-R5A-SM-3GIJD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943115
H2AC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09664
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93791
cell surface receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
CRCGN010_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3431
Septic Shock_Whole blood_GSE9692	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.5298
PMC7809845__F4	PFOCR Pathway Figure Associations 2023	1.0	null
TCF21-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K69048063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52018
Allantoin_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.019782
BRD-K00909602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41807
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.390455
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61177
sodium arsenite	CTD Gene-Chemical Interactions	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.864509
FOXH1-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
abnormal apoptosis	MPO Gene-Phenotype Associations	1.0	null
paroxetine-3904	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
immune response-activating signal transduction	GO Biological Process Annotations 2015	1.0	null
Perturb_9665_KD_TCF4_SRP188467	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
signal transduction	GO Biological Process Annotations 2015	1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-5636-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03658
15548366-Table2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29031
MAP3K7	Pathway Commons Protein-Protein Interactions	1.0	null
nitrofural-2459	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2BK120ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.060816
akt	Phosphosite Textmining Biological Term Annotations	1.0	null
TMK1	DepMap CRISPR Gene Dependency	1.0	6.18033
BRD-K94629607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87925
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4700-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K94344234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53359
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057651
PMC9026172__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Growth hormone synthesis, secretion and action	KEGG Pathways 2026	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NA-A5I1-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COMPOUND 20 [PMID: 30998356]	DGIdb Drug Targets 2026	1.0	0.113103
Perturb_2328_KD_SF3B5_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.27254
GSE88819_11_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSU	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55219
chromosome	Phosphosite Textmining Biological Term Annotations	1.0	null
MIS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11517
GSE210885_5_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.03819
ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.709572
r5 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71005
EGF receptor signaling pathway	PANTHER Pathways	1.0	null
GSE148321,GSE169423_2_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K94855649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05281
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853237
bortezomib	CTD Gene-Chemical Interactions	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_101_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
a-HCV6 ()	NURSA Protein Complexes	1.0	null
Vascular Diseases	CTD Gene-Disease Associations	1.0	1.10872
PMC8567138-Table_2.xlsx-Sheet1-IGFBP5_AND_IGFBP7_NOT_IGFBP3_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Lipid and atherosclerosis	KEGG Pathways 2026	1.0	null
GTEX-XUW1-0826-SM-4BOP6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967313
posteromedial visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.8877
BRD-K00914921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.03865
JA-85-SW39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236566
Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine	DrugBank Drug Targets	1.0	null
NB1	CCLE Cell Line Gene Expression Profiles	1.0	1.49849
PMC7617064-EMS151900-supplement-Extended_Data_Figure_5_Source_Data.xlsx-CLC_D9_DEG-Logfold_change_threshold_1_0_1_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2938-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Canagliflozin (hemihydrate)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0401841
PMC4060771-170289.f1.pdf-445-FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12457209-JCMM-29-e70858-s002.pdf-51-GATA4_GATA4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83307
interstitial lung disease	GWASdb SNP-Disease Associations	1.0	0.686763
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	0.738997
PMC12480273-12672_2025_3611_MOESM1_ESM.xlsx-csgene-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Chromosome Aberrations	CTD Gene-Disease Associations	1.0	1.78302
GAL3ST3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02538
Perturb_14385_KD_PAX8_SRP276625	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.47482
phthalylsulfathiazole-5614	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.7713
MCF7_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122389
Perturb_17640_OE_WWTR1_SRP298391	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.1028
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	2.33931
PMC7495487-41598_2020_71030_MOESM2_ESM.xlsx-Sheet1-NR1A1_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4690-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
dexamethasone-2242	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4720-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
hsa-miR-4659a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
MCF7_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148501
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20263
A549_WHI-P154_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150643
GSE145915_5_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K69375224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.52712
SP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.8018
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934628
BRD-K97707303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.91758
C3A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.89956
subcellular	GeneRIF Biological Term Annotations	1.0	null
Toll Like Receptor TLR1:TLR2 Cascade	Reactome Pathways 2014	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-PBX3_PBX3	Rummagene Transcription Factor Associations 2026	1.0	null
Ovarian Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CN-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182680,GSE182683_10_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121048
TAOK3	Pathway Commons Protein-Protein Interactions	1.0	null
Presubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81283
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39378
GATA3-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Infralimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37222
MDAPCA2B	CCLE Cell Line Gene CNV Profiles	-1.0	-1.422
propafenone-1722	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15514
GSE217115_2_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.883413
Cells - Cultured fibroblasts	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.662537
pten	Phosphosite Textmining Biological Term Annotations	1.0	null
ChIP_SOX17_20123909	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
prednisolone-5526	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Coronavirus disease - COVID-19	KEGG Pathways 2026	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211983_0_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.29911
BRD-K37989903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04064
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
SW1271	COSMIC Cell Line Gene Mutation Profiles	1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72034681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60469
GSE127916_1_v_2_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
FYN	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K63163033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.47105
GATA3_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRAF3	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_8872_KD_JCAD_SRP115209	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_6442_KO_RHO_SRP134183	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.27532
SUM225CWN	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.843496
hsa-miR-301b	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
GSE157383_3_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K43611837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00792
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebral cortex	HPA Tissue Protein Expression Profiles	1.0	1.14983
NR3C1	Pathway Commons Protein-Protein Interactions	1.0	null
2,4,3',5'-tetramethoxystilbene	CTD Gene-Chemical Interactions	1.0	null
BRD-K88447092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32306
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071768
cytosolic	Phosphosite Textmining Biological Term Annotations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7688-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4833
skin_5e	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.89792
BFTC-909	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839574
PMC6429383__F7	PFOCR Pathway Figure Associations 2024	1.0	null
hsa-miR-552	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
A549_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014088
PMC9528698-NIHMS1835045-supplement-Supp_table_53.xlsx-Sheet1-NC2_gene_symbol_DR1	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of protein serine/threonine kinase activity	GO Biological Process Annotations 2015	1.0	null
BRD-K92776249	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55962
wnt signaling pathway	KEGG Pathways	1.0	null
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.86487
Digitoxin_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0176147
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12494
KE39	CCLE Cell Line Gene Mutation Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6934-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K79678951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18874
abnormal locomotor activation	MPO Gene-Phenotype Associations	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.28839
positive regulation of molecular function	GO Biological Process Annotations 2015	1.0	null
amiloride-1890	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-4679-01B-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K96076719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04096
u26684	HPA Cell Line Gene Expression Profiles	-1.0	-0.894171
A704	CCLE Cell Line Gene Expression Profiles	1.0	1.471
BRD-K96560179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24463
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925488
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.961062
mutant	GeneRIF Biological Term Annotations	1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
KNS60	CCLE Cell Line Gene Mutation Profiles	1.0	null
A549_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019452
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
catalysis	Phosphosite Textmining Biological Term Annotations	1.0	null
CDCP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09017
PA-1	GDSC Cell Line Gene Expression Profiles	1.0	1.52576
cleft palate	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.162707
BRD-A78982410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14476
BRD-K27221973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9893
Perturb_15370_KD_TP53_SRP294453	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_12201_KO_ZEB1_SRP178052	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.1537
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.838803
response to stress	GO Biological Process Annotations 2015	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5J9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5931-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
MAP kinase activity	GO Molecular Function Annotations 2023	1.0	null
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33441
nes	HPA Cell Line Gene Expression Profiles	1.0	2.06017
tetramisole-2849	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AOB, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76599
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.24197
nerve-tissue-proteins	Phosphosite Textmining Biological Term Annotations	1.0	null
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.89956
purine nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
17571080-SuppTable2a	GeneSigDB Published Gene Signatures	1.0	null
PMC9314667-Table_1.xlsx-Regulons-SOX4_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_9449_OE_ALS/FUS_SRP297132	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.32891
GATA3_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25169
AKT1_activemutant_10_GDS2304	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.30843
BRD-K35975002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25299
betonicine-2207	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF274	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S4Q7-1526-SM-3K2AG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34915
abnormal neuron apoptosis	MPO Gene-Phenotype Associations	1.0	null
BRD-K37625653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.79347
PMC6219086__F6	PFOCR Pathway Figure Associations 2023	1.0	null
GSE240468_3_v_2_nfyc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3927	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
Insulin resistance	KEGG Pathways 2026	1.0	null
BRD-K86228587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90251
Cerebral Infarction	CTD Gene-Disease Associations	1.0	1.22664
crizotinib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0302761
protein phosphorylation	GO Biological Process Annotations 2025	1.0	null
BRD-K08036779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48988
PMC6853299-pbio.3000476.s011.xlsx-Fig_4A-RA_812_genes_expression_ratio_in_ZF_and_OF_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K32208085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14049
GAS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06216
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.9167
PMC8119428-41598_2021_89734_MOESM6_ESM.xlsx-Sheet1-Candidate_PORE_genes_potentially_bound_and_regulated_by_OCT4_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1972
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.73091
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TEAD2_TEAD2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K83872468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72815
DDX5	Pathway Commons Protein-Protein Interactions	1.0	null
r8 portion of the hypoglossal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23885
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224255
A-CA-04-2009(H1N1)_48Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.34248
neoplasm	GWASdb SNP-Phenotype Associations	1.0	1.04585
Perturb_9158_KD_RNF213_SRP345502	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.44613
novobiocin-na	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27157
toll-like receptor 9 signaling pathway	GO Biological Process Annotations 2015	1.0	null
Perturb_9406_KD_GATA6AS_SRP279802	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.34013
linked	GeneRIF Biological Term Annotations	1.0	null
SH3BP5	Pathway Commons Protein-Protein Interactions	1.0	null
terminal paraventricular area of THyA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02198
shell of SCH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25786
MCF7_Mocetinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115858
trypsin	Phosphosite Textmining Biological Term Annotations	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057738
olfactory bulb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.093229
Spinocerebellar ataxia	KEGG Pathways 2026	1.0	null
MCF7_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211725
BRD-K85271599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54153
Papillary Carcinoma of the Thyroid_Thyroid Gland (MMHCC)_GSE3678	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.59283
LB-100_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0352587
Stomach	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.572699
benzydamine-3169	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
major depressive disorder	GWASdb SNP-Disease Associations	1.0	0.762941
PMC6520398-41467_2019_10148_MOESM11_ESM.xls-FigS1a-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampal pyramidal layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.406315
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
TAL1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
mantle zone of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16854
Primary somatosensory area, upper limb, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44674
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963344
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052384
YES1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE216273,GSE216292_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KRAS.600.LUNG.BREAST_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
ARRB1	Pathway Commons Protein-Protein Interactions	1.0	null
phosphotransferase activity, alcohol group as acceptor	GO Molecular Function Annotations 2015	1.0	null
Sarcoma_SARC_TCGA-DX-A3UD-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
PMC9287735-mmc8.xlsx-MI_Related_Genes-TNF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
lycorine-3891	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K17372597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79848
PMC11130340-41598_2024_61926_MOESM1_ESM.pdf-28-L3MBTL1_L3MBTL1	Rummagene Transcription Factor Associations 2026	1.0	null
layer 6 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4251
Ischemia	CTD Gene-Disease Associations	1.0	1.08196
GSE202434,GSE202438_8_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HS695T	CCLE Cell Line Gene Mutation Profiles	1.0	null
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.948623
carisoprodol-6610	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JNJ-7706621	DGIdb Drug Targets 2026	1.0	0.0195754
hsa-miR-4419b	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.75851
Calcium-Binding Proteins	dbGAP Gene-Trait Associations	1.0	0.17264
Perturb_12688_KD_USP34_SRP150508	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.27647
TGFBR2_knockout_292_GSE46150	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.98642
lung disease	GWASdb SNP-Disease Associations	1.0	0.466495
Hepatitis B	KEGG Pathways 2026	1.0	null
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1329
BRD-K69922285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.95758
GSE205163,GSE205164_3_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.704685
Perturb_14374_KD_SRF_SRP150935	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.09405
PMC6008200__F7	PFOCR Pathway Figure Associations 2024	1.0	null
EB2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
b-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.221061
ULK3	Pathway Commons Protein-Protein Interactions	1.0	null
Diabetic cardiomyopathy	KEGG Pathways 2026	1.0	null
A549_BMS-536924_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132573
Tetracycline (hydrochloride)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0269758
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.814397
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.4804
Ritonavir_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0215024
Response to cytidine analogues (gemcitabine)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
Parkinson disease	PANTHER Pathways	1.0	null
CDK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81411
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.963991
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32995
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.897766
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0714
SARS-BatSRBD_48Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.56414
Measles Chicago-1_6Hour_16492729_GSE980	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.14919
PMC4732610__F6	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K90092568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02729
SNCA	Pathway Commons Protein-Protein Interactions	1.0	null
IZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.05417
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.784895
KYAE1	DepMap CRISPR Gene Dependency	1.0	9.59458
Perturb_14892_KO_H11_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.2081
NCI-H2228	GDSC Cell Line Gene Expression Profiles	-1.0	-1.5395
raphe magnus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13253
GSE189772,GSE189773_3_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.66464
Lassa Fever Virus_24hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.72282
LIMK2	Pathway Commons Protein-Protein Interactions	1.0	null
bronchopneumonia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.508041
MAP2K7	PhosphoSitePlus Substrates of Kinases	1.0	null
Insulin Signaling(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
GSE115542_5_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_WHI-P154_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196407
amebiasis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.500761
Peripheral_Blood_Mononuclear_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.36389
peripheral portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23731
Pitavastatin (Calcium)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0434887
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55E-0011-R5A-SM-2TC5N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975458
Perturb_8809_KD_FLNA_SRP318361	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72631
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SMPD3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE71468,GSE76476_0_v_1_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Carcinoma, Ductal, Breast	CTD Gene-Disease Associations	1.0	1.20881
ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K06475437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16509
CRCGN016_MCF10A.TP53.M_24H:F11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03174
PMC11474168-ccr-23-1242_supplementary_table_s4_suppst4.xlsx-AR_tumors_genes-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.465198
SA-32-CC58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315904
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0451
GTEX-P44H-0011-R1A-SM-3NM8J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2465
STAT3	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_71_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Retrosplenial area, lateral agranular part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.85753
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.30104
NFATC1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10297881__F13	PFOCR Pathway Figure Associations 2024	1.0	null
CRCGN012_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9773
PMC5013636-ncomms12601-s5.xlsx-AP1-Groups_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K80736363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11682
MDAMB436	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.704692
scaffolds	GeneRIF Biological Term Annotations	1.0	null
neurotransmitter receptor transport to postsynaptic membrane	SynGO Synaptic Gene Annotations	1.0	null
MAPK9	KEA Substrates of Kinases	1.0	null
JAK1	Kinase Library Tyrosine Kinome Atlas	1.0	97.37
FOXA2-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PHLPP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0289
Carcinoma, Ovarian Epithelial	DisGeNET Gene-Disease Associations	1.0	null
ability	GeneRIF Biological Term Annotations	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.03039
BRD-A64774838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94969
RAC1	Hub Proteins Protein-Protein Interactions	1.0	null
FTH1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_6486_KD_PRMT3_SRP370549	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.78612
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.244695
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02084
Doxorubicin	CTD Gene-Chemical Interactions	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-4667-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-K21176869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48652
GSE63048_11_v_6_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K14925361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20358
colchicine-644	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Apoptosis signaling pathway	PANTHER Pathways	1.0	null
intercalated cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.336704
PRDX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24842
stress-activated MAPK cascade	GO Biological Process Annotations 2023	1.0	null
carbohydrate derivative binding	GO Molecular Function Annotations 2015	1.0	null
Abemaciclib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0289381
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839574
membrane	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE205163,GSE205164_3_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133087_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
guaifenesin-4371	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QDT8-0011-R4A-SM-32PKM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892326
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0294071
carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.055625
primary motor cortex (area M1, area 4)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.874285
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94963
DUSP16	Pathway Commons Protein-Protein Interactions	1.0	null
Neoplasms	CTD Gene-Disease Associations	1.0	2.0666
G13 Signaling Pathway(Mus musculus)	WikiPathways Pathways 2014	1.0	null
MAP kinase activation in TLR cascade	Reactome Pathways 2014	1.0	null
GSE155695,GSE155696_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07407
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MH-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K29178949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45768
A549_Cerdulatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122707
Wnt Signaling Pathway(Mus musculus)	WikiPathways Pathways 2014	1.0	null
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20534
myd88-independent toll-like receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
Perturb_14056_OE_NFIB_SRP281947	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.99668
Butyrates	CTD Gene-Chemical Interactions	1.0	null
rho	Phosphosite Textmining Biological Term Annotations	1.0	null
hsa-miR-330-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
TP53-22127205-IMR90-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03981
AC-53-RC32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.28371
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K94452277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09167
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14174
layer 3 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16489
hsa-miR-942	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
L-Eflornithine (monohydrochloride)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0276281
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC6070530-41398_2018_200_MOESM3_ESM.xlsx-regional_cluster_PFC-MSC-age-bin_10_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
TGFBR1	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IK-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K98249237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06048
Toll Like Receptor TLR6:TLR2 Cascade	Reactome Pathways 2024	1.0	null
hypoactivity	MPO Gene-Phenotype Associations	1.0	null
Macrocephaly	DisGeNET Gene-Disease Associations	1.0	null
migration	Phosphosite Textmining Biological Term Annotations	1.0	null
abnormal hematocrit	MPO Gene-Phenotype Associations	1.0	null
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.5052
BCL2L11	Pathway Commons Protein-Protein Interactions	1.0	null
PMC5787244-13229_2018_191_MOESM1_ESM.xlsx-FOXO1_GSEA_txt-GENE_SYMBOL_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
stress-activated mapk cascade	GO Biological Process Annotations 2015	1.0	null
toll-like receptor tlr1:tlr2 signaling pathway	GO Biological Process Annotations 2015	1.0	null
orbital frontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.48994
specific developmental disorder	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
(3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime	DrugBank Drug Targets	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_96_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Weight Loss	CTD Gene-Disease Associations	1.0	1.91586
A361	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.05714
antiapoptotic	GeneRIF Biological Term Annotations	1.0	null
BRD-K45947503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12716
BL7759 (ABCC4)	NURSA Protein Complexes	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-0011-R8a-SM-2HMLG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44072
BRD-K44344720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11441
SKLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.54114
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Brain Lower Grade Glioma_LGG_TCGA-CS-6186-01A-12R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Myoclonus	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K59437706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05695
Integrin mediated cell adhesion	WikiPathways Pathways 2024	1.0	null
intracellular signal transduction	GO Biological Process Annotations 2015	1.0	null
papillary carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.220081
signal	Phosphosite Textmining Biological Term Annotations	1.0	null
hsa-miR-29c	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
PSMD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64818
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
Main olfactory bulb, mitral layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39603
GSE78199_2_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K98408839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66026
GSE142684_0_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-Row_names_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_14847_KD_PEG10_SRP055517	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.21987
CHP126	CCLE Cell Line Gene Expression Profiles	1.0	1.38519
cytoplasmic	Phosphosite Textmining Biological Term Annotations	1.0	null
Perturb_46_OE_ERG/MYC_SRP069177	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.45713
GSE203158_12_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Relaxin signaling pathway	KEGG Pathways 2026	1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-7140-01A-41R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
METTL23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50541
NCIH727	CCLE Cell Line Gene Expression Profiles	-1.0	-1.62205
lateral mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09493
GATA3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135350_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X585-0011-R2B-SM-46MVF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05137
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5QE-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MP-A4T6-01A-32R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hyperalgesia	CTD Gene-Disease Associations	1.0	1.35647
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37535
FPGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27672
MUS81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56456
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE211262,GSE211263_0_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101239_5_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48798
propylthiouracil-2837	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
regulation of gene expression	GO Biological Process Annotations 2015	1.0	null
regulation of transferase activity	GO Biological Process Annotations 2015	1.0	null
SMAD3-21741376-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC3294426__F3a	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04119
PMC4445818-13062_2015_58_MOESM2_ESM.xlsx-NSCL_Adjacency_Lists-Gene_symmbol_for_Protein_B_NHLH1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53936012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06597
Alzheimer Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
PMC2900209__F6	PFOCR Pathway Figure Associations 2023	1.0	null
Ouabain (Octahydrate)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0655779
urinary bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.11552
Darinaparsin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0153609
Perturb_2359_KD_TRIM25_SRP072302	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.61013
NCI-H2373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15091
Irinotecan_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0162489
PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.116711
GSE217405_3_v_2_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cardiomyopathies	CTD Gene-Disease Associations	1.0	1.53651
Sarcoma_SARC_TCGA-K1-A42X-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
caspases	Phosphosite Textmining Biological Term Annotations	1.0	null
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08163
BRD-K27398402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.17933
bemegride-3389	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_277_KD_ZHX2_SRP343502	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
respiratory system disease	GWASdb SNP-Disease Associations	1.0	0.448478
mRNA_JARID2_20075857	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Perturb_8038_KO_FOXA2_SRP350523	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.2595
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CDKN2A	Pathway Commons Protein-Protein Interactions	1.0	null
Drospirenone_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.025609
PMC10859477-Table6.xlsx-Supplementary_Table_6-10_key_AR-DEGs_obtained_by_LASSO_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148738
Pancreatic_Islets	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.897512
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
PVR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3159
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
rostral (anterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.45613
PMC11168926-41586_2024_7478_MOESM10_ESM.xlsx-F_KD1_KSEA_Kinase_z_scores-Supplementary_Table_8_Phospho-proteomic_profiling_of_endothelial_cells_E4EC_after_control_or_MYCT1_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04345
PMC4772274__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VJ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06024
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SOX4_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
Retrosplenial area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6111
dimethadione-3367	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PSN1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52951
Cocaine-Related Disorders	CTD Gene-Disease Associations	1.0	1.09506
Perturb_15021_KD_RelA_SRP078053	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.5619
GTEX-S3XE-0426-SM-3K2AC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27392
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.838803
PMC7057487__F4	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73684
GSE148252_7_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HAND1_cust_neg_HAND1	Rummagene Transcription Factor Associations 2026	1.0	null
Lucanthone_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0316608
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
fluoxetine_mus musculus_gpl1261 _gds2803	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormal catecholamine level	MPO Gene-Phenotype Associations	1.0	null
dopaminergic neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.302478
EW1	DepMap CRISPR Gene Dependency	1.0	12.9678
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nuclear part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
MCF7_Entinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145117
B cell activation	PANTHER Pathways	1.0	null
vascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.103934
GAK	Pathway Commons Protein-Protein Interactions	1.0	null
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.826889
BRD-K59120074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22396
tumorsuppressor	GeneRIF Biological Term Annotations	1.0	null
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03025
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-HAND1_neg_targets-ID_HAND1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
decreased susceptibility to dopaminergic neuron neurotoxicity	MGI Mouse Phenotype Associations 2023	1.0	null
Sarcoma_SARC_TCGA-FX-A3NJ-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE152699,GSE152723_3_v_2_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4224449-pone.0112193.s009.xlsx-PPI_MODULES_CLEAN_MAP_merg_OUT-Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
layer 3 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.87231
recruits	GeneRIF Biological Term Annotations	1.0	null
BRD-K67036882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36298
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HO-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
estradiol_homo sapiens_gpl14550_gse35034	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CYP27C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45538
BRD-K61274359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59531
GSE261563_7_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157383_3_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5676684__F6	PFOCR Pathway Figure Associations 2023	1.0	null
mapkinase signaling pathway	Biocarta Pathways	1.0	null
PMC3775648__F2	PFOCR Pathway Figure Associations 2024	1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.54755
Perturb_16818_KD_OTUD5_SRP290691	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.55204
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882955
BRD-K91944762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12192
periventricular stratum of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34717
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.867383
caco2	HPA Cell Line Gene Expression Profiles	-1.0	-0.894171
GTEX-R55F-0011-R6A-SM-2TF4L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952661
BCAP29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13811
hsa-miR-4643	TargetScan Predicted Conserved microRNA Targets	1.0	0.111118
TXK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26822
CDK5	Hub Proteins Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5709-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide	DrugBank Drug Targets	1.0	null
SP in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28097
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SR-01B-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15555_KO_SLFN11_SRP327912	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.02335
Perturb_10256_KD_TP53_SRP346937	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-19.5229
Epileptic encephalopathy, Lennox-Gastaut type	CTD Gene-Disease Associations	1.0	2.88009
Perturb_17786_KO_LDBI_SRP071739	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.10269
Perturb_14840_KD_GCM1_SRP358680	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.40422
PMC5787244-13229_2018_191_MOESM1_ESM.xlsx-FOXO1_GSEA_txt-PROBE_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
SW48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KRAS.300_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
Toll Like Receptor 7/8 (TLR7/8) Cascade	Reactome Pathways 2014	1.0	null
MCF7_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136071
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.572673
CORL23	DepMap CRISPR Gene Dependency	1.0	8.23662
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Triglyceride levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.1301
FOSL2	ENCODE Transcription Factor Targets	1.0	null
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83221
YAP1-20516196-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_10254_KO_WT1_ERP126063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.08402
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.844167
LENEP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00482685
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.16655
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.0452
KYSE-150	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-2666-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IM-95	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
YA-85-VH07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.337276
GTEX-QDT8-0011-R3A-SM-32PKR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23621
RAB3A_Mutation - D77G point mutation_GDS2483_698_mouse_Hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50361
Lung adenocarcinoma_LUAD_TCGA-71-8520-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
positive regulation of mapk cascade	GO Biological Process Annotations 2015	1.0	null
BT474	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.12835
CRCGN017_MCF10A.WT.HP_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16701
PMC7149918-12974_2020_1781_MOESM1_ESM.xlsx-Table_S7_CEBPB_Astrocyte_marker-Symbol_CEBPB	Rummagene Transcription Factor Associations 2026	1.0	null
Aggressive Behavior	DisGeNET Gene-Phenotype Associations	1.0	null
UNC119	Pathway Commons Protein-Protein Interactions	1.0	null
NR3C1	Hub Proteins Protein-Protein Interactions	1.0	null
NCIH1184	CCLE Cell Line Gene Expression Profiles	1.0	1.36951
Perturb_672_KO_IRF5_SRP212091	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.92079
BRD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39983
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4696-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of cardiovascular system physiology	GWASdb SNP-Phenotype Associations	1.0	0.453036
harmalol-5076	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Headache	CTD Gene-Disease Associations	1.0	1.09083
Perturb_5654_KD_FLI1_SRP117628	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.79677
GB1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.82182
IWS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85756
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89735
CRCGN015_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07265
mafenide-2287	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066433
Insulin Signaling(Mus musculus)	WikiPathways Pathways 2014	1.0	null
Perturb_10003_KD_GPKOW_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.79338
Cellular responses to stimuli	Reactome Pathways 2024	1.0	null
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.920557
ADCK3	Pathway Commons Protein-Protein Interactions	1.0	null
Canagliflozin_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.031832
radiation-effects	Phosphosite Textmining Biological Term Annotations	1.0	null
Hematuria	CTD Gene-Disease Associations	1.0	1.35386
brain	HPA Tissue Gene Expression Profiles	1.0	1.02391
FCERI mediated MAPK activation	Reactome Pathways 2014	1.0	null
BRD-K43203897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12118
NUR77	MotifMap Predicted Transcription Factor Targets	1.0	null
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.62153
KLF5-25053715-YYC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
layer 5 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72806
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
positive regulation of transferase activity	GO Biological Process Annotations 2015	1.0	null
PMC10289499-ms9-85-2662-s001.xlsx-Sheet2-PGR_PGR	Rummagene Transcription Factor Associations 2026	1.0	null
LYN	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34886
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HR-01A-21R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Oligo_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
sublayer 6a of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2844
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05647
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07947
Perturb_13797_KO_Phc1_SRP096055	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.21621
Seizures	DisGeNET Gene-Phenotype Associations	1.0	null
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.80134
GSE205687_1_v_0_mta1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Retrosplenial area, ventral part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.04553
GTEX-QVUS-0011-R4A-SM-3GAE7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01504
dorsolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.862673
protein complex involved in cell adhesion	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.09336
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_296_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Phenytoin (sodium)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0416642
GSE124471,GSE124488_1_v_0_lats1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.837363
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Oligospermia	CTD Gene-Disease Associations	1.0	1.92928
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.958041
NR3C1-21868756-MCF10A-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE125219,GSE125221_5_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAP3K4	KEA Substrates of Kinases	1.0	null
PMC6070710__F11	PFOCR Pathway Figure Associations 2023	1.0	null
Perturb_10006_KD_SF3B1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.47776
Anemia	CTD Gene-Disease Associations	1.0	1.21631
layer 6 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2752
receptor signaling protein serine/threonine kinase activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-QDT8-0011-R1A-SM-32PKS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00369
CRCGN014_HEPG2_3H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2195
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.927383
tamoxifen_homo sapiens_gpl3921_gse33366	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
letrozole_homo sapiens_gpl3921_gse33366	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KDM2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07595
abnormal seizure response to inducing agent	MPO Gene-Phenotype Associations	1.0	null
GSE155031_5_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
15785748-Table3	GeneSigDB Published Gene Signatures	1.0	null
fluphenazine-7234	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
longterm	GeneRIF Biological Term Annotations	1.0	null
Barrett Esophagus_Esophageal Tissue_GSE1420	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.56286
WNT5A	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_5633_KD_BRD4_SRP142503	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.5114
Perturb_7106_OE_Erbb2_SRP245626	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-A95970093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00563
ARGLU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19019
PMC7809845__F4	PFOCR Pathway Figure Associations 2024	1.0	null
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32142
GSE226249_2_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7051-11A-02R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNRPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75442
positive regulation of catalytic activity	GO Biological Process Annotations 2015	1.0	null
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9909
other	GeneRIF Biological Term Annotations	1.0	null
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.495516
other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.215147
preferentially	GeneRIF Biological Term Annotations	1.0	null
FOS	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K98935620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51378
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.81257
hsa-miR-629	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
10min_PPase_inhibitors vs ctrl_Hepa1-6 (Mouse) [18846507]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs	1.0	null
GTEX-OHPM-0008-SM-4E3IP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13077
neomycin-1383	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IRS1	Hub Proteins Protein-Protein Interactions	1.0	null
naltrexone-1363	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN014_HEPG2_24H:F08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23355
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.9798
CRCGN009_HEPG2_24H:N19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35044
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sphingolipid signaling pathway	KEGG Pathways 2026	1.0	null
PMC9730246-Table_7.xlsx-LPS_Val_up-Upstream_Regulator_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K07959057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21282
WM2664	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55292
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.070074
Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms	WikiPathways Pathways 2024	1.0	null
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76123
encoding	GeneRIF Biological Term Annotations	1.0	null
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.983995
Perturb_6308_KD_PUM1_SRP396076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.07847
icSARA deltaORF6_36Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.17407
BRD-K34604755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05376
Toll like receptor signaling	WikiPathways Pathways 2024	1.0	null
GSE128730_7_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Vismodegib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0268609
terazosin-2530	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC2858611__F3	PFOCR Pathway Figure Associations 2024	1.0	null
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
mkk4	GeneRIF Biological Term Annotations	1.0	null
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELK4	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC8566230-41388_2021_2018_MOESM3_ESM.xlsx-Cluster1_witn_MYCN_DEGs-Gene_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.4478
RERFLCAD1	CCLE Cell Line Gene Mutation Profiles	1.0	null
Stomach Neoplasms	CTD Gene-Disease Associations	1.0	1.10282
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_6618_KO_NEUROD1_SRP388830	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.0227
site	GeneRIF Biological Term Annotations	1.0	null
PMC4450280__F6	PFOCR Pathway Figure Associations 2024	1.0	null
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN1_n_EN1	Rummagene Transcription Factor Associations 2026	1.0	null
Ras Pathway	PANTHER Pathways	1.0	null
BRD-K11844860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29824
Perturb_13190_KO_Wnt5a_SRP346437	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.3814
tcof1_15522210_neuroblastoma_gof_mouse_gpl339_gds998	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.712245
decreased susceptibility to pharmacologically induced seizures	MPO Gene-Phenotype Associations	1.0	null
ATF2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE157555,GSE157556_4_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K26809097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2882
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_65_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1065
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.13987
GSE111247_14_v_12_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S7SE-0011-R5A-SM-2XCDA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02073
hypertension	GWASdb SNP-Disease Associations	1.0	0.875106
TAMATINIB	DGIdb Drug Targets 2026	1.0	0.0125669
intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.403811
chemosensitivity	GeneRIF Biological Term Annotations	1.0	null
HEC59	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE126345_7_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NB-31-SG91_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.277544
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943549
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45576
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-NR3C1_targets_enrichment-Unnamed_10_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2405	GDSC Cell Line Gene Expression Profiles	-1.0	-1.54262
GTEX-NPJ8-0011-R6a-SM-2HMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18175
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A262-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.09265
Inflammation	CTD Gene-Disease Associations	1.0	2.2248
hsa-miR-135a	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
decreased susceptibility to neuronal excitotoxicity	MPO Gene-Phenotype Associations	1.0	null
layer 2 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16896
Perturb_2564_KD_GATA3_SRP188712	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.42006
BRD-K35879814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02547
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4XL-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE145915_0_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE245778_1_v_0_runx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K58932103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.59142
GSE150072,GSE169209_4_v_11_qser1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal somatic motor system morphology	MPO Gene-Phenotype Associations	1.0	null
Gli2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.0742
GEFITINIB	DGIdb Drug Targets 2026	1.0	0.0147525
PMC10917207-Data_Sheet_1.pdf-7-CUX1_CUX1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.455983
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RU72-0011-R5A-SM-2TF6U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925774
CRCGN017_MCF10A.WT.HP_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2777
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89594
GSE125219,GSE125221_3_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8998691__F3	PFOCR Pathway Figure Associations 2024	1.0	null
scaffold	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-SNOS-1526-SM-32PLW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878841
IZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08779
BRD-K28320832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25938
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3358-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC38A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24686
focal adhesion	KEGG Pathways	1.0	null
SMARCD1-25818293-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12212
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04334
Perturb_7062_KO_Mbnl1_SRP014709	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.91871
CRCGN013_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72214
hsa-miR-4295	TargetScan Predicted Conserved microRNA Targets	1.0	0.241055
GSE151612_0_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PURG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37903
BRD-K70302892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83207
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4619-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.24038
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RNPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97338
hsa-miR-4645-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
thiamine-2894	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H2-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61408
BRD-K90673570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13207
endogenous depression	GWASdb SNP-Disease Associations	1.0	0.762941
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88702
Colorectal cancer	KEGG Pathways 2026	1.0	null
BRD-K53889798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11627
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cerebral Hemorrhage	CTD Gene-Disease Associations	1.0	1.09611
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_17_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921898
Lung squamous cell carcinoma_LUSC_TCGA-33-A4WN-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
suprachiasmatic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2529
CDK5	Pathway Commons Protein-Protein Interactions	1.0	null
GSE223334_1_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lung	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058423
CC-401	DGIdb Drug Targets 2026	1.0	0.254481
MARK4	Pathway Commons Protein-Protein Interactions	1.0	null
alclometasone-5752	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.477996
MCF7_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161619
Main olfactory bulb, granule layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-TFAP4_TFAP4	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4512-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12187926-41421_2025_809_MOESM8_ESM.xlsx-x_LPS-BMDCs-mouse_kinase_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0485
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
hsa-miR-4670-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Brain Lower Grade Glioma_LGG_TCGA-HT-7607-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
phosphorylation	GO Biological Process Annotations 2025	1.0	null
apoptosis	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.23596
MAPK3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K76400756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.79184
Focal adhesion	WikiPathways Pathways 2024	1.0	null
CRCGN016_MCF10A.TP53.M_24H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11177
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
mantle zone of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08485
SIN3A	ENCODE Transcription Factor Targets	1.0	null
BRD-K01534436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0335
Renal Insufficiency	CTD Gene-Disease Associations	1.0	1.59264
PMC4626177__F7	PFOCR Pathway Figure Associations 2024	1.0	null
Perturb_12021_KO_Nsmce2_SRP102277	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.13223
BRD-K32018176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20494
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70943
cytoplasm	LOCATE Curated Protein Localization Annotations	1.0	null
ID1_01_118	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60934
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5877-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.250023
Perturb_12069_OE_circDOCK1_ERP131190	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.59237
hsa-miR-506	TargetScan Predicted Conserved microRNA Targets	1.0	0.293524
Anxiety Disorders	CTD Gene-Disease Associations	1.0	1.06987
BRD-K92440102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06845
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25201
PMC4060771-170289.f1.pdf-667-NFE2L3_NFE2L3	Rummagene Transcription Factor Associations 2026	1.0	null
RBM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16484
Apoptosis - multiple species	KEGG Pathways 2026	1.0	null
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.57
rosiglitazone_mus musculus_gpl1261_gse11343	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ONDA9	DepMap CRISPR Gene Dependency	1.0	2.42008
Perturb_13373_KD_RPRD1B_SRP362755	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
SP in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14172
map-kinase-kinase-kinases	Phosphosite Textmining Biological Term Annotations	1.0	null
PMC4051800__F6	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-QDT8-2926-SM-32PKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4004
cisplatin_dictyostelium discoideum_gpl5382_gse8287	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Carcinoma, Squamous Cell	CTD Gene-Disease Associations	1.0	1.58724
PMC7657020-mmc5.xlsx-Cytokines_storm-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
EP300_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_KW-2449_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123051
Perturb_5634_KD_FLI1_SRP142503	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.46498
TRIM28_knockout_302_GSE32224	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.39065
GSE70935_3_v_4_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DOVITINIB	DGIdb Drug Targets 2026	1.0	0.011186
decreased susceptibility to neuronal excitotoxicity	MGI Mouse Phenotype Associations 2023	1.0	null
CRCGN014_HEPG2_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03242
Urogenital Abnormalities	CTD Gene-Disease Associations	1.0	1.41829
GTEX-X88G-0008-SM-47JWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936536
PMC7521313__F3	PFOCR Pathway Figure Associations 2023	1.0	null
harmalol-2892	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Thromboembolism	CTD Gene-Disease Associations	1.0	1.18587
Perturb_9996_KD_SBDS_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.38384
TRAF6 Mediated Induction of proinflammatory cytokines	Reactome Pathways 2014	1.0	null
boldine-4004	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pathways in cancer	KEGG Pathways 2026	1.0	null
TNIP1	Pathway Commons Protein-Protein Interactions	1.0	null
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.47683
GSE246461,GSE246463_5_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.2506
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47969
Megestrol_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0327078
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34015
GSE118816_2_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
neuron part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.051969
AD-91-LE02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206064
GSE127916_1_v_3_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
Rotenone	CTD Gene-Chemical Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61I-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
colorectal cancer	KEGG Pathways	1.0	null
effects	GeneRIF Biological Term Annotations	1.0	null
Sorbitol	CTD Gene-Chemical Interactions	1.0	null
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46581
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15339
primary motor cortex (area M1, area 4)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13529
Perturb_7810_KD_RAM_SRP091113	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.37377
GSE216538_1_v_3_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5316868__F2	PFOCR Pathway Figure Associations 2023	1.0	null
Perturb_15108_KD_MPP8_SRP218207	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.7721
ARRB2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K36me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-QMR6-0011-R8A-SM-32PKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39411
urinary system disease	GWASdb SNP-Disease Associations	1.0	0.199785
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27893
STAT3	ChEA Transcription Factor Targets	1.0	null
Apoptosis	KEGG Pathways 2026	1.0	null
FER	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K00263786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20692
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.16441
proto-oncogene-proteins	Phosphosite Textmining Biological Term Annotations	1.0	null
CD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00607988
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3929	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
superficial stratum of OCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33716
GSE175787_13_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
A-Vietnam-1203-2004(H5N1)_7Hour_None_GSE43204	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.96796
Brain - Spinal cord (cervical c-1)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.02335
praziquantel-1572	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lopinavir_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0221075
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87334
PMC8185945__F9a	PFOCR Pathway Figure Associations 2024	1.0	null
WORTMANNIN	DGIdb Drug Targets 2026	1.0	0.10715
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-8500-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amiodarone-5618	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Host pathogen interaction of human coronaviruses MAPK signaling	WikiPathways Pathways 2024	1.0	null
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.55504
GSE182680,GSE182683_5_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tetroquinone-4159	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE116930,GSE116935_1_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9253713-mmc3.xls-sufu_KD_HCC1954_DEGs-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Primary somatosensory area, mouth	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38771
jun kinase activity	GO Molecular Function Annotations 2015	1.0	null
cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_10127_Mut_MYB_SRP080924	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.41548
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
photoreceptors	GeneRIF Biological Term Annotations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6951-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14328_KD_GRHL2_SRP157074	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.48479
BRIMAPITIDE	DGIdb Drug Targets 2026	1.0	0.678615
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6827
Esophagus - Mucosa	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.638514
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34235
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7920-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4691-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Perturb_10250_KO_WT1_ERP126063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.64971
disease	GWASdb SNP-Disease Associations	1.0	0.079663
DB	DepMap CRISPR Gene Dependency	1.0	2.08395
limbic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04498
cellular response to stress	GO Biological Process Annotations 2015	1.0	null
PPARD	ChEA Transcription Factor Targets	1.0	null
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053715
salbutamol-4700	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.51095
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.62716
TP53	ChEA Transcription Factor Targets	1.0	null
GTEX-WVLH-0011-R4A-SM-3MJFS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05316
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-1912_ChIP-Seq_H3K9me1_2_demethylation_and_ChIP-Seq_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
atg9a	GeneRIF Biological Term Annotations	1.0	null
GTEX-WHSE-0011-R6A-SM-3P5ZP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873733
MCF7_MC1568_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012774
Wnt Signaling Pathway and Pluripotency(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
PMC12486367-Supplementary_Data2.pdf-453-HOXC6_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
brain_3c	HPA Tissue Sample Gene Expression Profiles	1.0	1.25046
PLCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36402
15980968-Table3b	GeneSigDB Published Gene Signatures	1.0	null
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
Encorafenib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00182668
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5001-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9109_KD_STAT3_SRP363695	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.45796
Primary visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.09015
GSE94849_1_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
IRINOTECAN HYDROCHLORIDE	DGIdb Drug Targets 2026	1.0	0.0299389
hsa-miR-4799-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Perturb_4859_KD_BCOR_SRP119523	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
PRKDC	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10859477-Table7.xlsx-Supplementary_Table_7-The_importance_score_of_15_AR-DEGs_by_RF_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Primary somatosensory area, nose	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5677
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998821
binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-OOBJ-2026-SM-3NB1R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837358
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5348
CP-320650-01-4379	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE102505_1_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cardiovascular Diseases	CTD Gene-Disease Associations	1.0	1.3793
Loperamide (hydrochloride)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0304738
Paresthesia	CTD Gene-Disease Associations	1.0	1.05349
Perturb_3570_KO_RAB5C_SRP285142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.92294
TET3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42102
protein binding	GO Molecular Function Annotations 2015	1.0	null
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13702
PMC11101176-Table1.XLSX-S_Table_4_DEG_XXvsXY-Supplementary_Table_4_Sex-biased_differentially_expressed_genes_DEG_of_male_and_female_cell_lines_at_D0_D4_D9_and_D37_after_differentiation_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
obstructive lung disease	GWASdb SNP-Disease Associations	1.0	0.766029
CRCGN016_MCF10A.TP53.M_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72282
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37415
Lung adenocarcinoma_LUAD_TCGA-62-A46R-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.9604
PMC6856008__F6	PFOCR Pathway Figure Associations 2023	1.0	null
PMC8755441-mmc3.xlsx-IRF1-UP-mono_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_14216_KO_Igf1r_SRP081104	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.29354
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-SYMBOL_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K50367303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67289
PMC8949786__F6	PFOCR Pathway Figure Associations 2024	1.0	null
toll-like receptor 10 signaling pathway	GO Biological Process Annotations 2015	1.0	null
dydrogesterone-4254	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NANOG_01_94	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.65252
Nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40894
PMC9314667-Table_1.xlsx-Regulons-MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
nicotinic acid-3381	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver Diseases	CTD Gene-Disease Associations	1.0	1.51255
vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.521888
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44797
posteroventral (inferior) parietal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.883413
H2BK20ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
layer 3 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07339
BRD-K56588599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00903
BRD-K97763545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96921
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.936953
disease of cellular proliferation	GWASdb SNP-Disease Associations	1.0	0.049515
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
Pericardial Effusion	CTD Gene-Disease Associations	1.0	1.07093
GSE144231_2_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_17712_KD_PPARG_SRP383556	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.40465
GSE135030_11_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_7928_KD_EXOSC3_SRP222099	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.90239
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.864855
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7424-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052225
Choline metabolism in cancer	KEGG Pathways 2026	1.0	null
mantle zone of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.01278
cytokines	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-RNOR-0011-R4A-SM-3GAD3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999159
PMC6080909-JEM_20171312_TableS1.xlsx-miR-196_predicted-Table_S1_miR-196a_b_predicted_targets_by_PITA_PicTar_TargetScan_and_DIANA_prediction_algorithms_ZFP1	Rummagene Transcription Factor Associations 2026	1.0	null
FLYWCH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98809
BRD-K23957028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03056
Immune System Diseases	CTD Gene-Disease Associations	1.0	1.04538
transient cerebral ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.252774
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
genistein-5595	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_669_KO_CX_SRP212091	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.77335
Perturb_15828_OE_Nrf2_SRP291726	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.61765
hsa-miR-764	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
RB1_KD_GSE50532_591_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30688
PMC7810546__F7	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K68575551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03361
Lung adenocarcinoma_LUAD_TCGA-67-3770-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tetracaine-7473	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K15591233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03518
Primary somatosensory area, trunk, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23885
JUN	ChEA Transcription Factor Targets	1.0	null
UD-03-SW43_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210241
BRD-K74694052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91944
Toll Like Receptor TLR6:TLR2 Cascade	Reactome Pathways 2014	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cognitive impairment	GWASdb SNP-Phenotype Associations	1.0	0.74366
PMC7042390__F9	PFOCR Pathway Figure Associations 2023	1.0	null
within	GeneRIF Biological Term Annotations	1.0	null
fluvastatin-3370	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Retrograde endocannabinoid signaling	KEGG Pathways 2026	1.0	null
18794137-SuppTable1c	GeneSigDB Published Gene Signatures	1.0	null
APOA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00467184
hsa-miR-4418	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
OC316	CCLE Cell Line Gene Mutation Profiles	1.0	null
TP53-22127205-IMR90-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.23486
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.980862
Visual areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44674
MCF7_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154557
Hyperemia	CTD Gene-Disease Associations	1.0	1.01966
harmol-6022	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K96549574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70525
WHRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.125
MCF7_AT9283_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190997
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.30414
mapk signaling pathway	KEGG Pathways	1.0	null
OCI-AML5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE87615_0_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7587013-GLIA-68-2613-s005.xlsx-ASCL1_Putative_Targets-Overlapping_Genes_ChIP-seq_8791_ASCL1_Assoc_Genes_vs_TCGA_RNA-seq_2136_Top_10_ASCL1-positively_Correlated_Genes_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BDNF	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRO-0011-R10A-SM-2I5EH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907824
collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.13147
PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4B-Up_Nanog_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-27a	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10997
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_202_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205324
diclofenac-2756	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.932251
16715129-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_1_TRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
layer 5 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23885
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.94648
Osteoclast differentiation	KEGG Pathways 2026	1.0	null
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041969
MKN74	CCLE Cell Line Gene Expression Profiles	-1.0	-1.9154
PMC8566230-41388_2021_2018_MOESM3_ESM.xlsx-Cluster3_no_MYCN_DEGs-Gene_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
nucleoside phosphate binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08335
Agranular insular area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1581
AST-487	DGIdb Drug Targets 2026	1.0	0.0275114
GNL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85198
Skin Neoplasms	CTD Gene-Disease Associations	1.0	1.57498
hippocampus (hippocampal formation)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.83088
BRD-K80819226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11963
hsa-miR-4709-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MJ-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARHGEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44505
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04236
abnormal homeostasis	MPO Gene-Phenotype Associations	1.0	null
PMC4138085__F2	PFOCR Pathway Figure Associations 2024	1.0	null
regulation of innate immune response	GO Biological Process Annotations 2015	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
h2o2	Phosphosite Textmining Biological Term Annotations	1.0	null
WDR62	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6148-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_3Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	3.09322
Cholestasis	CTD Gene-Disease Associations	1.0	1.07732
HBA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60802
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
Perturb_8787_KO_HNF6_SRP217514	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.04976
GSE229973_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K39813155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34538
Lung adenocarcinoma_LUAD_TCGA-93-7347-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Squamous Cell Carcinoma Of The Head And Neck	DisGeNET Gene-Disease Associations	1.0	null
GTEX-XMD1-0011-R6A-SM-4AT5K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917229
Osteoblast differentiation and related diseases	WikiPathways Pathways 2024	1.0	null
superficial stratum of PaS (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08102
KARPAS-422	GDSC Cell Line Gene Expression Profiles	1.0	2.26601
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.05583
SW48	CCLE Cell Line Gene Mutation Profiles	1.0	null
BRD-K95343362	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78417
asthma	GWASdb SNP-Phenotype Associations	1.0	0.576326
Lung squamous cell carcinoma_LUSC_TCGA-85-8071-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K86746660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.40486
abnormality of the lung	GWASdb SNP-Phenotype Associations	1.0	0.588613
Cellular Senescence	Reactome Pathways 2014	1.0	null
diphemanil metilsulfate-4591	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Hypochlorous Acid	CTD Gene-Chemical Interactions	1.0	null
protein serine/threonine/tyrosine kinase activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K82064887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31263
ARNT_01_240	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.65078
BRD-K33705415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2145
BRD-K14163107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11767
GSE180185_9_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
small molecule binding	GO Molecular Function Annotations 2015	1.0	null
hsa-miR-4766-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
superficial stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00409
BRD-K13938991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03256
Perturb_2916_KD_FOXO1_SRP192099	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
NB17	COSMIC Cell Line Gene Mutation Profiles	1.0	null
JNK INHIBITOR VIII	DGIdb Drug Targets 2026	1.0	0.145418
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09135
nterminal	GeneRIF Biological Term Annotations	1.0	null
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06479
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24714
Melanoma	CTD Gene-Disease Associations	1.0	1.19014
temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.742976
Perturb_8885_KD_FOXM1_ERP109084	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.9697
Non-alcoholic fatty liver disease	KEGG Pathways 2026	1.0	null
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03025
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	Reactome Pathways 2014	1.0	null
sulforafan	CTD Gene-Chemical Interactions	1.0	null
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2309
cortical	Phosphosite Textmining Biological Term Annotations	1.0	null
Clotrimazole_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0265262
NFIA_Deficiency_GDS2775_640_mouse_Postnatal brains (at P16)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Perturb_1038_OE_C15orf48_SRP289006	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.16027
DB-73-BC12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213646
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
CRCGN013_HEPG2_24H:I16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05761
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.391527
posteromedial visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15231
LMO2-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_3574_KD_OVOL1_SRP056220	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.94178
GSE95688_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4677-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
PANC1	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.35072
metronidazole-2003	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FAS (CD95) signaling pathway	PID Pathways	1.0	null
ciprofibrate-3561	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
apoptotic	Phosphosite Textmining Biological Term Annotations	1.0	null
Sarcoma_SARC_TCGA-PC-A5DL-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7440-11A-01R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K57270624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40794
CCK81	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46115
ischemic	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56228
Perturb_18439_KD_G3BP1_SRP265843	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.47852
PMC11185845-NIHMS1996282-supplement-Table_S1.xls-TableS1_txt-Kasumi_miR130_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC11161988-12906_2024_4523_MOESM3_ESM.pdf-8-NR3C1_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor cortex (area M1, area 4)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03596
Lateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2344
MCF7_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128592
dorsolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.91822
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.09878
Lung squamous cell carcinoma_LUSC_TCGA-85-A4CL-01A-41R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
brain_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.09176
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EK-01A-22R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PVOW-2626-SM-32PL8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855967
substantia nigra reticulata, isthmic part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.675
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.12766
Flocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26282
SMPD1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834318
Perturb_599_OE_HOTAIR_SRP342161	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.83905
Perturb_8895_KD_FGD5_SRP281196	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.73508
9-(4-Hydroxyphenyl)-2,7-Phenanthroline	DrugBank Drug Targets	1.0	null
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K97761115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04368
hydroxyprogesterone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64032
CRCGN017_MCF10A.WT.HP_24H:N10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0372
kinase	GeneRIF Biological Term Annotations	1.0	null
Tucatinib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0239622
Perturb_41_OE_MicroRNA101_SRP328889	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.40051
HE-18-HV99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245728
HNF4alpha_KO_GDS1915_173_mouse_Small intestine	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Seizures	CTD Gene-Disease Associations	1.0	1.42321
site of polarized growth	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.257289
GTF3C1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04769
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-0.832434
496100453_HIP_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.06671
GSE125219,GSE125221_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_39_KD_ATRX_SRP308220	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	19.3979
BRD-K64704925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13978
Perturb_14890_KO_H15_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.51627
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A42R-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RT-A6Y9-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ISL1-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
bronchial disease	GWASdb SNP-Disease Associations	1.0	0.672523
PTCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7953
BRD-K75506133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19117
A549_SRT1720 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158208
BRD-K36055854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6293
PMC7230378__F5	PFOCR Pathway Figure Associations 2023	1.0	null
H3K4me1_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NANOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10087
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-R55E-0011-R11A-SM-2TC6I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833917
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1HW-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6257835__F6	PFOCR Pathway Figure Associations 2023	1.0	null
hsa-miR-495	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
BRD-K21936026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08558
hsa-miR-335	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
BRD-K12111274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08618
TBX3-20139965-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
ErbB signaling pathway	KEGG Pathways 2026	1.0	null
Arid5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.2399
OB mitral cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56839
TGF-beta signaling pathway	PANTHER Pathways	1.0	null
vorinostat	CTD Gene-Chemical Interactions	1.0	null
ventrolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00069
Lung squamous cell carcinoma_LUSC_TCGA-56-8309-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tolfenamic acid-1437	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.884248
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67229
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.83893
BRD-K86263698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09105
regulation of nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE81803,GSE81912_3_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3526425-1471-2164-13-572-S3.xlsx-STAT6-STAT6_STAT6	Rummagene Transcription Factor Associations 2026	1.0	null
trif-dependent toll-like receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
renal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.13809
PMC6755252__F5	PFOCR Pathway Figure Associations 2023	1.0	null
ISOPROTERENOL	DGIdb Drug Targets 2026	1.0	0.0814338
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28541
BRD-K20951097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20648
centromedian nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19044
survival	GeneRIF Biological Term Annotations	1.0	null
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82882121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23131
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19253
hsa-miR-3140-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.212286
BRD-K78615842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56596
clomipramine-6825	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
clozapine-6988	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-124	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
MCF7_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165979
MCF7_SNS-314 Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150963
disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.217352
Edoxaban (tosylate monohydrate)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0400998
H3K9ac_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43N-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JNK cascade	GO Biological Process Annotations 2023	1.0	null
BRD-K56106571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71888
GSE160083,GSE160084_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MASOPROCOL	DGIdb Drug Targets 2026	1.0	0.0433159
GSE157960_2_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTF2A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04257
GSE65617_5_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXD1_FOXD1	Rummagene Transcription Factor Associations 2026	1.0	null
central nervous system disease	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
TGFB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83034
core of T-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12608
FOXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0975
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXA2_FOXA2	Rummagene Transcription Factor Associations 2026	1.0	null
Epileptic Encephalopathy	DisGeNET Gene-Disease Associations	1.0	null
IZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.989285
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0424
C-type lectin receptor signaling pathway	KEGG Pathways 2026	1.0	null
MCF7_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0104796
EHEB	CCLE Cell Line Gene Expression Profiles	1.0	2.30886
protein modification process	GO Biological Process Annotations 2025	1.0	null
set	GeneRIF Biological Term Annotations	1.0	null
HDAC1	Hub Proteins Protein-Protein Interactions	1.0	null
Posterior parietal association areas, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02419
NCI H322M	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.926198
pirenperone-5274	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7591-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
substantia nigra reticulata, m1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14288
MCF7_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116138
heart	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.321685
positive regulation of signaling	GO Biological Process Annotations 2015	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905157
ABHD15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4358
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5364-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WT1-25993318-PODOCYTE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_2327_KD_SF3B3_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.61307
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32787
BXPC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.932882
BDNF signaling pathway(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
GTEX-QMR6-0011-R6A-SM-32PKP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00943
Perturb_12570_KD_MSI1_SRP185353	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.05078
MCF7_AR-42_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017173
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.83088
decreased susceptibility to induction of seizure by inducing agent	MPO Gene-Phenotype Associations	1.0	null
PMC12187926-41421_2025_809_MOESM8_ESM.xlsx-w_SRPK2-KD-mouse_kinase_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NLGN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54131
PMC5109294-celldisc201641-s3.xls-NANOGP8_DEGs-Unnamed_9_NANOGP8	Rummagene Transcription Factor Associations 2026	1.0	null
OSC19	DepMap CRISPR Gene Dependency	1.0	2.1864
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.131497
GSE168587,GSE168752_3_v_1_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
doxylamine-1973	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4725-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64093
frontal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074121
Perturb_4933_OE_KLF17_ERP131758	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.91972
KYSE150	CCLE Cell Line Gene Mutation Profiles	1.0	null
etanidazole-2510	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
layer 1 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10445
alzheimer's disease	GWASdb SNP-Disease Associations	1.0	0.565109
ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC2536824__F4	PFOCR Pathway Figure Associations 2024	1.0	null
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12106
BCL2	Hub Proteins Protein-Protein Interactions	1.0	null
PMC3636213-pgen.1003459.s012.xlsx-Sheet1-KD_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Sarcoma_SARC_TCGA-DX-A48U-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0042
PMC12611713-Table2.xlsx-Sheet_1-Diabetes_AND_Validation_Database_NOT_Training_Database_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE	DrugBank Drug Targets	1.0	null
dementia	GWASdb SNP-Disease Associations	1.0	0.34284
NRF2-31884422-A549-HUMAN-LUNG-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
olfactory bulb, principal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40216
18722011-SuppTable2o	GeneSigDB Published Gene Signatures	1.0	null
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-SUPPLEMENTARY_TABLE_12_Bulk_RNA-seq_results_of_invasive_fractions_from_GBM43_CTH_knockdwn_vs_GBM43_control_cells_invading_3D_hydrogels_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6338-01A-12R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_TGX-221_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150781
regulation of immune system process	GO Biological Process Annotations 2015	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_39_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal voluntary movement	MPO Gene-Phenotype Associations	1.0	null
THERAPEUTIC GONADOTROPIN	DGIdb Drug Targets 2026	1.0	0.290835
posteroventral (inferior) parietal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.930741
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07314
regulation of protein modification process	GO Biological Process Annotations 2015	1.0	null
chronic obstructive pulmonary disease	GWASdb SNP-Disease Associations	1.0	1.50225
MAPK10	Hub Proteins Protein-Protein Interactions	1.0	null
Spinal Muscular Atrophy	DisGeNET Gene-Disease Associations	1.0	null
ROR2	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC10534007-Table_3.xlsx-S8_unique_down_MSC_V_2-345_elements_included_exclusively_in_VMCUB1_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GM2345	BioGPS Cell Line Gene Expression Profiles	1.0	0.915343
BRD-K81619018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67491
T cell receptor signaling pathway	KEGG Pathways 2026	1.0	null
endometrial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.450701
nascent polypeptide-associated complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.251476
Prostate adenocarcinoma_PRAD_TCGA-M7-A724-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K21036759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10985
GTEX-O5YT-0008-SM-4E3IQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.019
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.446972
regulation of phosphorylation	GO Biological Process Annotations 2015	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.3894
ventrolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.874285
BRD-K85659077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38062
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SIX1_SIX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142684_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205163,GSE205164_3_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE237040_6_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KYSE150_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	2.216
CRCGN015_MCF10A_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.9773
MAP kinase activation	Reactome Pathways 2024	1.0	null
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76625
caudate nucleus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
STMN2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE131887_1_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cloxacillin-1443	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-1.96567
PMC11168926-41586_2024_7478_MOESM10_ESM.xlsx-G_KD2_KSEA_Kinase_z_scores-Supplementary_Table_8_Phospho-proteomic_profiling_of_endothelial_cells_E4EC_after_control_or_MYCT1_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FV-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24808
hsa-miR-3128	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
MAPK Cascade(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
stratum radiatum of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.964188
BRD-A12822115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3079
cellular phenotype	MPO Gene-Phenotype Associations	1.0	null
PMC7810546__F7	PFOCR Pathway Figure Associations 2024	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9631451__F8	PFOCR Pathway Figure Associations 2024	1.0	null
GSE151090_5_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
diflunisal-1908	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary motor cortex (area M1, area 4)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07825
H3K27me3_CH12.LX_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-125a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
BRD-K34228325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09286
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6V9-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
parasitic protozoa infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.068518
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1d-List_of_2302_of_genes_differentially_regulated_by_SOX2_FDR_0_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
b-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.172799
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.54191
GSE174701_4_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
hexetidine-2457	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
15656903-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
Diisocyanate-induced asthma	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.6
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
neutrophil	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.10756
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40347
FGF signaling pathway	PANTHER Pathways	1.0	null
MCF7_Valproic acid sodium salt_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123015
pulmonary artery endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.391553
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04068
POU5F1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71788
GSE217405_3_v_2_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09953
PMC2794539__F5	PFOCR Pathway Figure Associations 2024	1.0	null
fludroxycortide-4702	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K69468381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41407
GSE216540_0_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sulindac-5528	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
betahistine-2833	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Toll Like Receptor 4 (TLR4) Cascade	Reactome Pathways 2014	1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10011
BRD-K94744294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20871
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-650	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7870-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2840-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54856
Brain Lower Grade Glioma_LGG_TCGA-HT-7603-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN012_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75011
resistance	GeneRIF Biological Term Annotations	1.0	null
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903303
PMC7335061-41467_2020_17150_MOESM4_ESM.xlsx-Table_S3-LIN28B_correlates_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MSN	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_12315_KO_AGO1_SRP136692	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.9477
posteroventral (inferior) parietal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.32676
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.5375
Lung adenocarcinoma_LUAD_TCGA-50-5942-01A-21R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30491662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04664
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_35_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2348
Main olfactory bulb, inner plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16707
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UMUC3	CCLE Cell Line Gene Mutation Profiles	1.0	null
MCF7_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00968149
regulation of signaling	GO Biological Process Annotations 2015	1.0	null
nicergoline-1374	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21828
AG-013608-5904	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K81475473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53379
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ERBB2_knockdown_238_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.74907
inner CP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.888516
HCC33	CCLE Cell Line Gene CNV Profiles	1.0	1.62839
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H4-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RECOMBINANT FIBROBLAST GROWTH FACTOR 1	DGIdb Drug Targets 2026	1.0	0.678615
MCF7_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113724
PMC7614775-EMS178742-supplement-Proteomics_Table_2.pdf-172-IRF1_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal neuron physiology	MPO Gene-Phenotype Associations	1.0	null
positive regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
MCF7_AZD1480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158746
PSMG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00717
Perturb_14378_KD_PAX8_SRP276625	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.51307
SARS-CoV_60Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.53128
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.933513
Retrosplenial area, lateral agranular part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16896
layer 5 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33716
MAPK signaling pathway	KEGG Pathways 2026	1.0	null
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.188915
A549_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186975
WM88	CCLE Cell Line Gene CNV Profiles	1.0	1.39742
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_167_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-AA3A-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K79228133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31934
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.965954
Pyridoxine (hydrochloride)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0284767
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997418
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326215
Anteroventral periventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00893
LOXIMVI	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61225
hela	HPA Cell Line Gene Expression Profiles	-1.0	-0.894171
regulation of phosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17321
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87663
PMC9305137-PATH-256-297-s005.xlsx-CIC_associated_DE_genes_IDH1-W-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE128333_4_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ovarian	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC4252505__F3	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K59893572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46616
MARK2	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Alvespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124669
PMC2694838-1471-2164-10-241-S2.xls-Sheet1-Regulated_genes_by_ZNF191_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
ARAF	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6713698-109_2019_1809_MOESM2_ESM.xlsx-AR-PCOS-Gene_List_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-M7-A725-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOP-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.964759
SNU1040	CCLE Cell Line Gene Mutation Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2914-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Intracellular signaling and cytoskeletal dynamics	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
PMC9232097__F7	PFOCR Pathway Figure Associations 2024	1.0	null
PMC5380511__F7	PFOCR Pathway Figure Associations 2024	1.0	null
Perturb_14762_KD_LATS1/LATS2_SRP345234	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.99224
BRD-K79829201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14091
nucleoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.12962
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.5307
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.988593
GSE130864_0_v_1_tincr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7521313__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Dihydroartemisinin_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0303075
Primary somatosensory area, upper limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89553
Stroke	CTD Gene-Disease Associations	1.0	1.27316
BRD-K45520793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04032
PMC12686523-41421_2025_842_MOESM6_ESM.xlsx-Table_S5-Supplementary_Table_S5_-_Target_genes_of_FOXG1_in_GBM_FOXG1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_17636_KD_SENCR_SRP168566	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.30572
tauopathy	GWASdb SNP-Disease Associations	1.0	0.565109
Lung squamous cell carcinoma_LUSC_TCGA-85-7698-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.670966
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_11594_OE_MYOD1_SRP106379	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.0598
BRD-K43431234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.83318
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.628293
TRIM28	ENCODE Transcription Factor Targets	1.0	null
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03589
Stage Ii Ovarian Cancer Ajcc V8	DisGeNET Gene-Disease Associations	1.0	null
MAP2K7	KEA Substrates of Kinases	1.0	null
BRD-K47170544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03889
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20893
hsa-miR-1197	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24285
PMC6381758__F7	PFOCR Pathway Figure Associations 2023	1.0	null
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26661
MyD88:Mal cascade initiated on plasma membrane	Reactome Pathways 2014	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-8254-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39396484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3513
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8144624-41598_2021_90212_MOESM7_ESM.xlsx-apla04621_NOD_LPS-Gene_ID_KEGG_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HEK 293 T-rex    	BioGPS Cell Line Gene Expression Profiles	1.0	1.20792
Novel intracellular components of RIG I like receptor pathway	WikiPathways Pathways 2024	1.0	null
PMC12240782-Table3.xlsx-Sheet1-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
Fetal_Brain_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.950399
PMC4533315__F3	PFOCR Pathway Figure Associations 2024	1.0	null
response to stimulus	GO Biological Process Annotations 2015	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PF382	CCLE Cell Line Gene CNV Profiles	1.0	1.52556
immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.048852
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09595
marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.568424
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.1484
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GF-A2C7-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
purine nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.43146
BRD-K80851151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22798
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7506
Rectum adenocarcinoma_READ_TCGA-AG-3731-11A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.912896
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231995
A549_WP1066_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178374
endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.078475
BRD-A25243629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34973
BRD-K30699866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.95046
lhx8_18509161_newborn_ovary_lof_mouse_gpl1261_gds3254	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.224272
MCF7_Pracinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213251
Anorexia	DisGeNET Gene-Disease Associations	1.0	null
BRD-K90358614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08404
GSE205316,GSE205317_0_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_induced_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231773
DNA damage response only ATM dependent 	WikiPathways Pathways 2024	1.0	null
male	Phosphosite Textmining Biological Term Annotations	1.0	null
PMC8335696__F5	PFOCR Pathway Figure Associations 2024	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
ALPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00549775
EZH2	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-3976	TargetScan Predicted Conserved microRNA Targets	1.0	0.072324
biological regulation	GO Biological Process Annotations 2015	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47N-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hemorrhage	CTD Gene-Disease Associations	1.0	1.86991
JUN-21703547-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of rna metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27768
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6228-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7057487__F4	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K06029218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.86088
diperodon-1575	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
17210682-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
Balsalazide (sodium hydrate)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0298872
BRD-A68526335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26557
BRD-K12884811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10576
amacrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.230656
PMC9307586__F12	PFOCR Pathway Figure Associations 2024	1.0	null
spiperone-1559	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_16954_KO_MLX_SRP183152	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.92013
SP in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02794
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54906
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8332-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K91810283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35225
Raltitrexed_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0281002
GRM	CCLE Cell Line Gene Expression Profiles	-1.0	-1.79388
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13314
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52273
BRD-K83820627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02703
Lung adenocarcinoma_LUAD_TCGA-05-5423-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MyD88-independent cascade	Reactome Pathways 2014	1.0	null
CLPP_KO_GDS4791_539_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43418
Lung adenocarcinoma_LUAD_TCGA-67-3773-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
conformations	GeneRIF Biological Term Annotations	1.0	null
HDAC9	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_8652_KD_DIAPH1_SRP399521	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.37209
diclofenac-5861	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CSK	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_16609_KO_Larp7_SRP189392	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.55005
BRD-K81370109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02655
GSE237040_0_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primidone-3402	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mRNA_NR2F2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PMC4605373__F4	PFOCR Pathway Figure Associations 2023	1.0	null
Perturb_6470_KD_PDRG1_SRP314383	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_6_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
mdm2	GeneRIF Biological Term Annotations	1.0	null
TAOK1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-3910	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
positive regulation of immune response	GO Biological Process Annotations 2015	1.0	null
MyD88 dependent cascade initiated on endosome	Reactome Pathways 2014	1.0	null
jnk1	GeneRIF Biological Term Annotations	1.0	null
A549_AZD1480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.010399
GTEX-QVUS-0011-R10A-SM-3GIK3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47416
DCLK1+ progenitor cell_Large intestine_Human	CellMarker Gene-Cell Type Associations	1.0	null
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral preoptic nucleus, PO2 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06429
BRD-K06784595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79597
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-1270	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Hypertrophy	CTD Gene-Disease Associations	1.0	1.52439
BRD-K83254798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00596
BRD-K62533881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53692
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.56259
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04044
BRD-K76701247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24733
BRD-K16268355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82229
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58169
GTEX-UTHO-0011-R3A-SM-3GIK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2001
BRD-K49733350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1135
PMC3669416-pone.0064838.s001.xls-mHTT-NFKB1_NFKB1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6856008__F6	PFOCR Pathway Figure Associations 2024	1.0	null
GSE108675_3_v_0_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QDVN-2426-SM-2S1Q4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33032
CRCGN015_HEPG2_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.18326
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DLG1	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K87082948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96481
molecular_function	GO Molecular Function Annotations 2015	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.49145
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23488
GSE236486_1_v_0_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MITOMYCIN	DGIdb Drug Targets 2026	1.0	0.096945
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anorexia	CTD Gene-Disease Associations	1.0	1.23648
CDK1	KEA Substrates of Kinases	1.0	null
PMC3775648__F2	PFOCR Pathway Figure Associations 2023	1.0	null
Perturb_1037_Mut_C15orf48_SRP289006	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.98364
BRD-K87159315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01111
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.307377
nerve-growth-factors	Phosphosite Textmining Biological Term Annotations	1.0	null
JNK cascade	GO Biological Process Annotations 2025	1.0	null
RELA	Pathway Commons Protein-Protein Interactions	1.0	null
GSE131887_1_v_4_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NPJ7-0011-R6a-SM-2I3G7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929413
Primary visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9036
hsa-miR-4659b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE154074_1_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
16611997-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
map-kinase-kinase-4	Phosphosite Textmining Biological Term Annotations	1.0	null
testicular cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.109732
CHD1	ENCODE Transcription Factor Targets	1.0	null
BRD-K75814223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1214
A549_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00869671
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
gliclazide-1720	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14393
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ETC-206_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0269238
MCF7_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125778
BRD-K97343426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04847
GSE156923_2_v_1_rbmx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TAGLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03874
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72757
GSE234043_0_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13629
Perturb_14052_OE_NFIB_SRP281947	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.38374
Thrombosis	CTD Gene-Disease Associations	1.0	1.61483
protein modification process	GO Biological Process Annotations 2023	1.0	null
response to light stimulus	GO Biological Process Annotations 2023	1.0	null
No annotation - 9	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
MYOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05668
BRD-K52924481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01066
NR3C1	ChEA Transcription Factor Targets	1.0	null
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_9639_KO_CHCHD2_SRP212886	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.96691
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_12_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11525188-41588_2024_1893_MOESM4_ESM.xlsx-Supplementary_Table_4-Supplementary_Table_4_NSD2_signature_genes_and_GREAT_genes_associated_with_NSD2-dependent_and_NSD2-independent_AR_binding_sites_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_6460_KO_EZH2_SRP136292	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.46334
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13712
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
HNF4A	ChEA Transcription Factor Targets	1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K26786741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17799
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1633
LTBR_INHIBITION - 1 Day_GDS2005_728_mouse_Lymph nodes  (MG-430B)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850328
GSE120200,GSE127269_1_v_2_asxl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXA2-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
RS4-11	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.583122
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77094
EFM19	CCLE Cell Line Gene CNV Profiles	-1.0	-1.74508
medial parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.932875
CRCGN015_HEPG2_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17481
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
Pancreatic adenocarcinoma pathway	WikiPathways Pathways 2024	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_68_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_4237_OE_ERG/FLI1_SRP403488	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.45934
FAM53C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1434
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.992707
BRD-K14392329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16278
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839574
GTEX-QMR6-1426-SM-32PLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59168
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45291
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.465198
TANZISERTIB	DGIdb Drug Targets 2026	1.0	0.678615
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46561
transferase activity, transferring phosphorus-containing groups	GO Molecular Function Annotations 2015	1.0	null
occipital cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34198
CORL311	CCLE Cell Line Gene Expression Profiles	1.0	1.68633
PMC6257835__F6	PFOCR Pathway Figure Associations 2024	1.0	null
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7783806__F8	PFOCR Pathway Figure Associations 2024	1.0	null
UMUC16	DepMap CRISPR Gene Dependency	1.0	3.53926
WSUDLCL2	CCLE Cell Line Gene Expression Profiles	1.0	2.3662
GTEX-VJWN-0426-SM-3GIJI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907803
PMC6073502__F1	PFOCR Pathway Figure Associations 2023	1.0	null
multidrug	GeneRIF Biological Term Annotations	1.0	null
neurons	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29679
Arrhythmias, Cardiac	CTD Gene-Disease Associations	1.0	1.01474
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04927
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Minodronic acid_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0197112
Atrophy	CTD Gene-Disease Associations	1.0	1.99106
blood vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.284253
PNU-0293363-6563	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21365
BRD-K64055457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13717
GSE147876,GSE147877_4_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE88819_0_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25275
Toll Like Receptor 10 (TLR10) Cascade	Reactome Pathways 2024	1.0	null
BRD-A97270959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08828
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.923612
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45W-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.191167
Hepatitis C infection_Hepatocyte_GSE2067	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.21409
monocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075916
TP53-18474530-U2OS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE103003_1_v_0_zeb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Poisoning	CTD Gene-Disease Associations	1.0	1.81611
PMC5859839__F11	PFOCR Pathway Figure Associations 2023	1.0	null
Protein kinase-like domain	InterPro Predicted Protein Domain Annotations	1.0	null
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.565001
GSE135030_3_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH1339	CCLE Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-3663-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
BRD-K03343162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.13278
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.956779
JHOM2B	CCLE Cell Line Gene Mutation Profiles	1.0	null
PF-00562151-00-5954	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
niridazole-2440	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K96054771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5334
Irf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	107.253
CRCGN011_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.3498
SP in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.889271
GTEX-N7MS-0008-SM-4E3JI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854902
nephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.114152
MAP3K4	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7771094-12920_2020_832_MOESM5_ESM.txt--ATF2_ATF2	Rummagene Transcription Factor Associations 2026	1.0	null
Meiotic prophase fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901658
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02471
HCMV_24Hour-AG_pretreatment_20173022_GSE17948	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.47297
SD-15-WR01_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.334852
hsa-miR-4520b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
PMC11384093-mmc1.xlsx-886-drug_target-VDR_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152699,GSE152723_3_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
orbital frontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.934809
cerebral lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.744214
hepatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.127023
BRD-K67556876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20013
Fc receptor signaling pathway	GO Biological Process Annotations 2025	1.0	null
SW1463	CCLE Cell Line Gene CNV Profiles	1.0	2.08496
Piriform-amygdalar area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12015
cefadroxil-4161	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormality of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.301113
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	Reactome Pathways 2024	1.0	null
PMC8566230-41388_2021_2018_MOESM3_ESM.xlsx-Cluster1_no_MYCN_DEGs-Gene_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K58883090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79105
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12724
Perturb_14887_KO_H13_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.05684
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01314
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_100_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5986469__F8	PFOCR Pathway Figure Associations 2024	1.0	null
posteroventral (inferior) parietal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.12418
SLC16A7+ cell_Lung_Human	CellMarker Gene-Cell Type Associations	1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.70727
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-PRRX2_PRRX2	Rummagene Transcription Factor Associations 2026	1.0	null
lymphnode_5c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.983425
BRD-K92644013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38367
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NPJ7-2726-SM-2I3FT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25467
outer CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.8968
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.836687
H3K9me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69033
Lung squamous cell carcinoma_LUSC_TCGA-18-3412-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_64_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A61767497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05909
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04806
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07814
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.850623
Progesterone-mediated oocyte maturation	KEGG Pathways 2026	1.0	null
icSARS CoV_24Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	0.922461
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11353_KD_METTL3_SRP292229	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.77383
asthma	GWASdb SNP-Disease Associations	1.0	0.672523
terminal subparaventricular area of THyA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03499
GTEX-QDT8-0011-R7A-SM-32PKF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00339
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18238
GSE227891_2_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
irf1_17409403_nih3t3_gof_mouse_gpl81_gds2752	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.34886
periventricular stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61615
GTEX-QVJO-0011-R4A-SM-2S1QL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31624
KCNS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52724
blood vessel endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.087513
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.880064
BRD-K96280720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9579
hepg2	HPA Cell Line Gene Expression Profiles	-1.0	-0.894171
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4168
GF1-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
toll like receptor signaling pathway	KEGG Pathways	1.0	null
EHEB	GDSC Cell Line Gene Expression Profiles	1.0	2.48025
GTEX-XLM4-3026-SM-4AT6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47569
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.22326
external part of AOV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35563
Thymopentin_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0330999
Lung adenocarcinoma_LUAD_TCGA-NJ-A55A-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA2	ENCODE Transcription Factor Targets	1.0	null
GTEX-TSE9-0011-R8A-SM-3DB7R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938056
BRD-K79904333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95505
PMC8566230-41388_2021_2018_MOESM3_ESM.xlsx-Cluster2_no_MYCN_DEGs-Gene_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
bcl-2	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE144231_6_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Taenia tecta, ventral part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19044
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160083,GSE160084_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11266089-Table3.XLSX-Fig1_Disease_targets-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1187	GDSC Cell Line Gene Expression Profiles	1.0	1.80983
GTEX-S4UY-0006-SM-3K2A7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90824
BRD-K81647747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08397
KP3	CCLE Cell Line Gene Mutation Profiles	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
hsa-miR-509-3-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
STAT3-18555785-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K66954388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32795
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.655024
phosphatidylinositol-3-kinases	Phosphosite Textmining Biological Term Annotations	1.0	null
POU5F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54901
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D4-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMRT-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Salmonella infection	KEGG Pathways 2026	1.0	null
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine	DrugBank Drug Targets	1.0	null
ketanserin-1593	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.47054
TTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69315
Decitabine_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0323563
Toll-like Receptor Cascades	Reactome Pathways 2024	1.0	null
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.898095
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25483
GSE157555,GSE157556_3_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mesothelioma_MESO_TCGA-SC-A6LM-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_44_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_9062_KD_POU5F1_SRP100928	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.05338
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.230931
PMC11361850__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Ulcerative Colitis_Peripheral blood mononuclear cell_GSE3365	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.0631
NR3C1-21868756-MCF10A-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K57782577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29859
IMR-5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE211983_0_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
r2 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84077
Perturb_6422_KD_LOC646329_SRP220725	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.5985
PMC8120713__F4	PFOCR Pathway Figure Associations 2024	1.0	null
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.179829
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1127
mitogenactivated	GeneRIF Biological Term Annotations	1.0	null
hydrogen-peroxide	Phosphosite Textmining Biological Term Annotations	1.0	null
bronchogenic carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058345
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_61_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2509
BRD-K31377965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.62849
dorsolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02489
Prostate adenocarcinoma_PRAD_TCGA-EJ-7797-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03981
Nanoparticle-mediated activation of receptor signaling(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09474
Retrosplenial area, dorsal part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40373
PMC7793877__F5	PFOCR Pathway Figure Associations 2023	1.0	null
PMC9493050__F7	PFOCR Pathway Figure Associations 2024	1.0	null
GSE200839,GSE233826_5_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_13372_KD_RPRD1B_SRP362755	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.7268
MARVELD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60965
brain	Phosphosite Textmining Biological Term Annotations	1.0	null
fluoxetine_mus musculus_gpl1261_gds2803	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pentetic acid-5629	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48384
A549_G007-LK_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135099
A549_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166655
erastin-6412	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NGF	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5451-11A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G2_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.944499
BRD-K19084671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4752
LN18	BioGPS Cell Line Gene Expression Profiles	1.0	1.01948
pulmonary artery endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.192224
Perturb_4673_KO_Taf3_SRP007832	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	16.1241
Neoplasm Invasiveness	CTD Gene-Disease Associations	1.0	1.19146
BRD-K40266835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.99226
GSE169334,GSE169336_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.26842
PMC6028720__F3	PFOCR Pathway Figure Associations 2024	1.0	null
TACC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10145
Phosphoaminophosphonic Acid-Adenylate Ester	DrugBank Drug Targets	1.0	null
(3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime	DrugBank Drug Targets	1.0	null
PMC2536824__F4	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K18178356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23032
neurite	Phosphosite Textmining Biological Term Annotations	1.0	null
MCF7_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201614
19185848-TableS1	GeneSigDB Published Gene Signatures	1.0	null
POLR2A_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904399
PMC8567035-CTM2-11-e578-s001.xlsx-ATF6-SEC61A1_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18259
cerebellar cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.129417
P3HR1	CCLE Cell Line Gene Expression Profiles	1.0	1.86
A549_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154265
DA-48-NC44_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288177
p2 portion of the parabrachial pigmented nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00893
layer 1 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24794
central nervous system disease	GWASdb SNP-Disease Associations	1.0	0.086622
BRD-K83307202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46433
MAPK Cascade(Mus musculus)	WikiPathways Pathways 2014	1.0	null
cancer	GWASdb SNP-Disease Associations	1.0	1.19631
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212525
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.200999
GSE203158_1_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06118
Th1 and Th2 cell differentiation	KEGG Pathways 2026	1.0	null
GSE116299_4_v_5_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE89057_0_v_1_sox5_human	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.855885
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.598858
GTEX-S341-1826-SM-3K2AB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06819
developmental disorder of mental health	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
agranulocytosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.237357
MAPK9	Hub Proteins Protein-Protein Interactions	1.0	null
neuron projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.161905
DD-74-PJ26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339392
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.869187
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.0382
craf1mek1erk2	GeneRIF Biological Term Annotations	1.0	null
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
AZD-8055_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0325474
BRD-A78042852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95191
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
neurotoxicity	GeneRIF Biological Term Annotations	1.0	null
ventrolateral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22902
RL7	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.951709
econazole-2396	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
calcium-binding proteins	GAD Gene-Disease Associations	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_50_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PHA-00851261E-3773	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A81552806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58611
GATA3_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NB5	GDSC Cell Line Gene Expression Profiles	1.0	1.61483
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12063
PMC3030591__F4	PFOCR Pathway Figure Associations 2023	1.0	null
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.53652
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.79484
GSE182179_5_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNAI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45062
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIF-mediated TLR3/TLR4 signaling	Reactome Pathways 2014	1.0	null
neurons	GeneRIF Biological Term Annotations	1.0	null
20460173-ImmPortCD40LandAnti-IgMvsControl	GeneSigDB Published Gene Signatures	1.0	null
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11596949-medi-103-e40529-s003.xlsx-TCMSP_1-PGR_PGR	Rummagene Transcription Factor Associations 2026	1.0	null
lateral septal nucleus, intermediate part, periventricular	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34824
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y6-01A-21R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.0174
JHH5	CCLE Cell Line Gene Mutation Profiles	1.0	null
impaired coordination	MGI Mouse Phenotype Associations 2023	1.0	null
GSE237040_2_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC2783859__F3a	PFOCR Pathway Figure Associations 2024	1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
response to light stimulus	GO Biological Process Annotations 2025	1.0	null
GTEX-NPJ8-0011-R5a-SM-2HMJY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08621
PMC4138085__F2	PFOCR Pathway Figure Associations 2023	1.0	null
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212127
limbic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.699853
BRD-K35222206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.60363
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.834333
santonin-3877	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
19455257-TableS10	GeneSigDB Published Gene Signatures	1.0	null
Fc epsilon RI signaling pathway	KEGG Pathways 2026	1.0	null
GSE173810_0_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE155031_6_v_3_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Trichostatin A_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0350271
methapyrilene-1588	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EPHB2	Pathway Commons Protein-Protein Interactions	1.0	null
Retrosplenial area, dorsal part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.37869
Pulmonary Edema	CTD Gene-Disease Associations	1.0	1.41694
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2569
DUSP16	DEPOD Substrates of Phosphatases	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A905-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880792
BRD-K83898323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60242
MAZ	ENCODE Transcription Factor Targets	1.0	null
0179445-0000-4289	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S7SE-0011-R8A-SM-2XCDG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05285
PMC11956947-media-4.xlsx-C_GSEA_gene_sets-TGAYRTCA_ATF3_Q6_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Diseases	CTD Gene-Disease Associations	1.0	1.09646
BRD-K75360899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38912
PMC7430912-12864_2020_6954_MOESM7_ESM.xlsx-GENES_NOT_FOUND-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-544b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
flumequine-2276	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051644
Bimiralisib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.029287
clorgiline-5005	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7474-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU719	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45516
HCC1897	CCLE Cell Line Gene CNV Profiles	1.0	1.46788
Prestwick-692-4424	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Nausea	CTD Gene-Disease Associations	1.0	1.4449
NB7	DepMap CRISPR Gene Dependency	1.0	2.27396
Perturb_9118_KO_PCK2_ERP116055	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.68327
GSE114553_0_v_1_lhx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Death	CTD Gene-Disease Associations	1.0	1.2013
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52273
Perturb_14017_KD_PGBD1_SRP398441	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.35095
neutropenia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.257358
Retrosplenial area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22998
GTEX-U3ZM-1226-SM-3DB9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38556
Anterior olfactory nucleus, external part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03499
urinary bladder cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.230382
TP53	JASPAR Predicted Transcription Factor Targets	1.0	null
Pain	CTD Gene-Disease Associations	1.0	1.79006
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
frozen	GeneRIF Biological Term Annotations	1.0	null
Perturb_12237_KO_ZMYND8_SRP130942	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.35241
Glaucoma	DisGeNET Gene-Disease Associations	1.0	null
MCF7_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111885
abnormal seizure response to pharmacological agent	MPO Gene-Phenotype Associations	1.0	null
MCF7_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124551
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.52846
Regulation of toll-like receptor signaling pathway(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.84585
Perturb_9959_KD_SUPT6H_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.60415
ARSENIC TRIOXIDE	DGIdb Drug Targets 2026	1.0	0.0783018
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7437-01A-21R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HUP-T3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15474
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
fc epsilon ri signaling pathway	KEGG Pathways	1.0	null
H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-TSE9-0011-R1A-SM-3DB7E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862758
HUVEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.850485
H3K9ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RAC2	Pathway Commons Protein-Protein Interactions	1.0	null
MyD88-independent TLR4 cascade	Reactome Pathways 2024	1.0	null
TENT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59049
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A818-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r6 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07084
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.23383
SUDHL4	CCLE Cell Line Gene Expression Profiles	1.0	3.07232
639V	CCLE Cell Line Gene Expression Profiles	-1.0	-2.51576
H3K9me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
fallopiantube_8d	HPA Tissue Sample Gene Expression Profiles	1.0	0.840637
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.904571
Primary somatosensory area, trunk, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44674
A549_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161189
cervicitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.580439
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ISHIKAWAHERAKLIO02ER	CCLE Cell Line Gene Expression Profiles	-1.0	-1.69736
Childhood Neuroblastoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37821
BENTAMAPIMOD	DGIdb Drug Targets 2026	1.0	0.339308
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92878
GSE229973_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
Perturb_11703_KD_MIR31HG_SRP051359	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.60808
GSE118939_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
mir29b	GeneRIF Biological Term Annotations	1.0	null
KIF18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15214
Peripheral artery disease	GWAS Catalog SNP-Phenotype Associations	1.0	0.165905
CRCGN009_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.54829
BRD-K53356402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62608
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
A549_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129382
APLP2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE193258,GSE193259_5_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ROPN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00513194
gonad	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071851
transferase activity	GO Molecular Function Annotations 2015	1.0	null
spleen	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.971897
SNGM	CCLE Cell Line Gene Mutation Profiles	1.0	null
toll-like receptor 4 signaling pathway	GO Biological Process Annotations 2015	1.0	null
ARRB1	Hub Proteins Protein-Protein Interactions	1.0	null
PROTEASOME INHIBITOR	DGIdb Drug Targets 2026	1.0	0.101792
KDM4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25128
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6986
Degenerative Polyarthritis	DisGeNET Gene-Disease Associations	1.0	null
BRD-K85234739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23779
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5884-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Radotinib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0301982
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5694-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47036878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28972
basal ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MCF7_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130716
GSE210885_3_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06847
HEC108	CCLE Cell Line Gene Mutation Profiles	1.0	null
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05487
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056721
GSE143944_1_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
spiradoline-3901	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.323126
Anteromedial nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43039
MCF7_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177282
abnormal physiological response to xenobiotic	MPO Gene-Phenotype Associations	1.0	null
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
endopiriform nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.13999
positive regulation of protein kinase activity	GO Biological Process Annotations 2015	1.0	null
RL	GDSC Cell Line Gene Expression Profiles	1.0	1.74259
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.268388
CD8_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-2.0941
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10359
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.961204
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5861
A549_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183561
BRD-K64001802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.58821
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_58_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
bipolar disorder	GWASdb SNP-Disease Associations	1.0	0.971735
cdk5	Phosphosite Textmining Biological Term Annotations	1.0	null
Fatigue	CTD Gene-Disease Associations	1.0	1.21695
SMPD2	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_2837_KD_CDK12_SRP073459	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.78937
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lobelanidine-2897	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CD71+_EarlyErythroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.18829
DF-32-EL16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.511545
HMGN2_02_20	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	6.56986
GSE81803,GSE81912_4_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01009
PRMT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45785
Lung Diseases	CTD Gene-Disease Associations	1.0	1.8128
H1_Derived_Neuronal_Progenitor_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.907179
DYNC1LI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01646
Perturb_10621_OE_Mst1_SRP398098	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-NL3G-0008-SM-4E3JX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872988
layer 1 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03339
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
hsa-miR-128	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
COMPOUND 25C [PMID: 36649216]	DGIdb Drug Targets 2026	1.0	0.203585
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.7335
Postsubiculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71469
genistein-638	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE145215_0_v_3_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
guaifenesin-3897	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Entorhinal area, lateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21716
H3K27me3_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_7054_KO_Tead1_SRP229838	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
hsa-miR-892b	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
GSE68156_0_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8S9-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular protein modification process	GO Biological Process Annotations 2015	1.0	null
HUT102	CCLE Cell Line Gene Mutation Profiles	1.0	null
secretory granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.080231
Venous Thrombosis	CTD Gene-Disease Associations	1.0	1.21951
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
BRD-K16802067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03253
SKNDZ	CCLE Cell Line Gene Expression Profiles	1.0	1.45639
N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine	DrugBank Drug Targets	1.0	null
BRD-K96243955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52701
Protein processing in endoplasmic reticulum	KEGG Pathways 2026	1.0	null
Infertility, Female	CTD Gene-Disease Associations	1.0	1.87376
MCF7_Quisinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00558184
ITK_knockout_241_GSE12465	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.89176
Perturb_8881_KD_CSL_SRP142324	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.78397
Curcumin	CTD Gene-Chemical Interactions	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044303
located	GeneRIF Biological Term Annotations	1.0	null
PMC6928094-395_2019_765_MOESM7_ESM.xls-DEGs_AR7_vs_Pre-patterned-List_of_differentially_expressed_genes_in_AR7_vs_Pre-patterned_cells_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
Inflammatory mediator regulation of TRP channels	KEGG Pathways 2026	1.0	null
DAUDI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC4531812-13058_2015_618_MOESM11_ESM.xlsx-Metabric_Sparse_KM_976-TFAP2B_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.481788
inferolateral temporal cortex (area TEv, area 20)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43123
Bed nuclei of the stria terminalis, anterior division, ventral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05611
Glucocorticoid receptor regulatory network	PID Pathways	1.0	null
CRCGN011_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6773
SNU81	CCLE Cell Line Gene Expression Profiles	-1.0	-3.15254
BRD-K41289356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09722
uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.399334
Lung squamous cell carcinoma_LUSC_TCGA-98-A53A-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.1578
jun phosphorylation	GO Biological Process Annotations 2015	1.0	null
BRD-K22383829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62437
Nafamostat (mesylate)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0332319
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
epidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.01625
deleterious	GeneRIF Biological Term Annotations	1.0	null
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.2259
layer 2 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43572
ECGI10	CCLE Cell Line Gene CNV Profiles	-1.0	-2.00185
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5316868__F2	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K42181022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80369
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.7419
PMC12254336-41698_2025_947_MOESM1_ESM.docx-5-STAT3-S727_predicted_kinases_Top_30_PhosphoSitePlus_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WZTO-0011-R6B-SM-4E3J6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974866
hindbrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060023
PMC7305081-10120_2020_1045_MOESM1_ESM.xlsx-Tab2-Mutation-MAF_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
THOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05411
VBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19887
BRD-K12260863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72585
superficial stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14288
intermediate stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13374
thp1	HPA Cell Line Gene Expression Profiles	-1.0	-0.894171
STAT6	MotifMap Predicted Transcription Factor Targets	1.0	null
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.947279
Colonic Neoplasms	CTD Gene-Disease Associations	1.0	1.3388
SU-DHL-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36124
PMC12141477-41467_2025_60329_MOESM3_ESM.xlsx-log2FC_0_5_cut_off_-_258_genes-Supplementary_Data_1_Genes_identified_by_both_HLF_overexpression_OE_and_knockout_KO_RNAseq_HLF	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5679-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-197	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
EB2	CCLE Cell Line Gene Mutation Profiles	1.0	null
Perturb_12256_KO_CD274_SRP215305	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-16.3344
PMC8283158-mmc2.xlsx-TCF4_NPC-Gene_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68605096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30185
BRD-K39342915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.73524
GSE192870_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
betaarrestin2	GeneRIF Biological Term Annotations	1.0	null
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04657
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8E-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_KO_3T3_ONLY_2084_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5103
Toll-like receptor signaling pathway	KEGG Pathways 2026	1.0	null
Malignant Tumor Of Cervix	DisGeNET Gene-Disease Associations	1.0	null
PMC6219086__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Belzutifan_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00997807
P30-OHK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.33944
TTI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23491
POU3F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21499
PMC2794539__F5	PFOCR Pathway Figure Associations 2023	1.0	null
hsa-miR-4312	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
HDAC1_KO_GDS2294_67_mouse_embryonic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Perturb_1076_KO_Mr1_ERP107271	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.62864
MCF7_Abexinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00669712
Primary somatosensory area, mouth, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9934
BRD-K82814367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.36285
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.332048
BRD-K59099886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52649
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66304
Perturb_15413_KD_KDM3B_SRP187702	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.92449
Filgotinib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.036431
GTEX-QVJO-0011-R6A-SM-2S1QN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22308
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32787
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17152
GSE210885_2_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21048
mapk	GeneRIF Biological Term Annotations	1.0	null
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2688
PMC9270251-mmc2.xlsx-2_Filtered_DEGs_Control_vs_KD_2-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_233_KD_BRG1_SRP048577	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
noscapine-5851	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE137818_3_v_7_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mesothelioma_MESO_TCGA-MQ-A4LJ-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Movement Disorders	CTD Gene-Disease Associations	1.0	1.26917
Ebolavirus(ZEBOV)_3day_PBMCs_rNAPc2treated_21987740_GSE24943	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	0.04926
diffuse large b-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.392257
OB inner plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48306
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16431
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
K562	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.2414
c-jun	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K95499061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01972
regulation of sequence-specific dna binding transcription factor activity	GO Biological Process Annotations 2015	1.0	null
CRCGN016_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37477
mononuclear phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07489
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
Language Development Disorders	CTD Gene-Disease Associations	1.0	1.0608
Urinary Bladder Neoplasms	CTD Gene-Disease Associations	1.0	1.7568
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11496110-42255_2024_1140_MOESM3_ESM.xlsx-ST18_Gene_view-Supplementary_Table_18_Top_100_FAM46C_co-expressed_genes_according_to_Islet_Gene_View_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
Primary visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.24691
BRD-K95160020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27544
chrysin-5505	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_Flavopiridol HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143645
BRD-K83775558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71579
VMCUB1	DepMap CRISPR Gene Dependency	1.0	2.00391
BRD-A19962819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10569
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5988-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.981056
SIMA	CCLE Cell Line Gene Expression Profiles	1.0	1.60773
GTEX-R55D-0626-SM-3GAD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00299
GSE93674_2_v_3_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8423434-mmc7.xlsx-SOX2_Primed-Genes_n_3042_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K74676765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24404
Innate Immune System	Reactome Pathways 2014	1.0	null
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94847
abnormality of the immune system	GWASdb SNP-Phenotype Associations	1.0	0.058847
Vinblastine (sulfate)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0240624
ES8	DepMap CRISPR Gene Dependency	1.0	7.26303
KYSE30	CCLE Cell Line Gene Mutation Profiles	1.0	null
asiaticoside-3504	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_7467_KD_AFF4/AFF1_SRP136956	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.36049
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K40826084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53278
cell projection part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.045749
GTEX-NPJ7-0008-SM-4E3JS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827541
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
pimozide-3178	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
aminophylline-5395	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CDK1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8484
GSE184210_0_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SP in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.994672
Parkinson disease	KEGG Pathways 2026	1.0	null
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.963774
MAP kinase kinase activity	GO Molecular Function Annotations 2023	1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mechanisms	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
J30-8	DGIdb Drug Targets 2026	1.0	1.01792
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49028
GSE169205_0_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
cerebral lobe	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_11691_OE_MYC_SRP253943	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.59588
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01508	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.54484
Perturb_3634_KO_NEAT1_DRP008265	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.32192
SEMA4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37182
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.3466
BRD-K34069025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80347
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.158692
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.225
preopto-hypothalamic band	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03339
Presubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2344
CCDC134	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91011
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.944499
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.7427
Perturb_7304_OE_SF3B1_SRP286876	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.947
NVP-BHG712_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0257367
CRCGN016_MCF10A.TP53.M_24H:N24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43972
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K20009653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.6005
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52273
decreased apoptosis	MPO Gene-Phenotype Associations	1.0	null
GSE150072,GSE169209_6_v_11_qser1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ras signaling pathway	KEGG Pathways 2026	1.0	null
pheneticillin-5763	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF1-21803131-MONOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SARS-CoV_48Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.65498
Perturb_14339_KD_CTCFL_SRP306444	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.53996
Lung adenocarcinoma_LUAD_TCGA-05-4249-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OCILY3	CCLE Cell Line Gene CNV Profiles	1.0	1.63354
MAP2K4	KEA Substrates of Kinases	1.0	null
Gait speed in old age	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
binds	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-512-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
ion binding	GO Molecular Function Annotations 2015	1.0	null
acemetacin-5460	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
disease of mental health	DISEASES Curated Gene-Disease Association Evidence Scores	1.0	null
Toll Like Receptor 2 (TLR2) Cascade	Reactome Pathways 2024	1.0	null
integrin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.095077
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22309
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
primary motor-sensory cortex (samples)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.845875
vincamine-3865	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Gli1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.653
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5177-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14882_KO_H11_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.89685
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
amphotericin B-2441	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE77178_6_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
insulin-responsive compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.310358
MCF7_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0103157
CHST4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20797
positive regulation of protein serine/threonine kinase activity	GO Biological Process Annotations 2015	1.0	null
Perturb_2617_KO_RB1_SRP252396	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.54528
GSE163862_2_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K63579322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.59776
BRD-K09146396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24186
GTEX-PWO3-0011-R6A-SM-2I5F3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07979
BRD-K06428422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63472
RIPK2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
CD40LG	Pathway Commons Protein-Protein Interactions	1.0	null
SOX2	ChEA Transcription Factor Targets	1.0	null
tightly	GeneRIF Biological Term Annotations	1.0	null
GM2313	BioGPS Cell Line Gene Expression Profiles	1.0	1.67882
GSE126127_0_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PRDM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35386
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NPJ8-0011-R4a-SM-2HML3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901171
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989156
adenyl nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
renal	GeneRIF Biological Term Annotations	1.0	null
MAPK10	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K08679933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81573
PMC4380073__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6823
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BF-49-QA17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.634083
Human immunodeficiency virus 1 infection	KEGG Pathways 2026	1.0	null
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.839574
GSE169205_3_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4411413__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
icSARS CoV_30Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.36511
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980507
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_induced_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
moroxydine-2027	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Osimertinib (mesylate)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0407471
ANKRD33B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29289
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06429
Futibatinib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0177307
salivarygland_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.883593
JUN	Hub Proteins Protein-Protein Interactions	1.0	null
BRD-K15620114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98525
BRD-K27226238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16665
region	GeneRIF Biological Term Annotations	1.0	null
MAP2K4	PhosphoSitePlus Substrates of Kinases	1.0	null
BRD-K62320774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25905
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
sirolimus_homo sapiens_gpl2895_gse16944	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Abnormality Of Brainstem Morphology	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K46726368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40158
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2446
ADP	HMDB Metabolites of Enzymes	1.0	null
MAPKBP1	Pathway Commons Protein-Protein Interactions	1.0	null
AZD1390_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0261998
BRD-K22443456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10457
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.895592
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00455
4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide	DrugBank Drug Targets	1.0	null
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19432
KARPAS422	CCLE Cell Line Gene Expression Profiles	1.0	2.05197
COMPOUND 11 [PMID: 26431428]	DGIdb Drug Targets 2026	1.0	0.203585
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRWD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17017
TRAF2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC5013636-ncomms12601-s5.xlsx-TCF3-Groups_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
periventricular stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.06148
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81J-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.43426
PMC9498168__F8	PFOCR Pathway Figure Associations 2024	1.0	null
SCH	GDSC Cell Line Gene Expression Profiles	-1.0	-1.84159
Perturb_13934_KD_GDE2_SRP065260	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.27245
HDAC1	Pathway Commons Protein-Protein Interactions	1.0	null
MTA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1014
BRD-K79568363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48549
PMC5352059__F4	PFOCR Pathway Figure Associations 2024	1.0	null
GSE152055_0_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
response to light stimulus	GO Biological Process Annotations 2015	1.0	null
Pentagastrin_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.027198
Focal adhesion	KEGG Pathways 2026	1.0	null
metabolic	GAD High Level Gene-Disease Associations	1.0	0.293278
Brain Edema	CTD Gene-Disease Associations	1.0	1.34285
GEMIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36654
mapk	Phosphosite Textmining Biological Term Annotations	1.0	null
Fluvoxamine_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0259504
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7430-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
impaired	Phosphosite Textmining Biological Term Annotations	1.0	null
TDOTT	DepMap CRISPR Gene Dependency	1.0	5.86719
CB-82-PL01_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.480634
Retrosplenial area, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10049
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K17885598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61865
hsa-miR-27b	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
positive regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
jnk	GeneRIF Biological Term Annotations	1.0	null
lateral ventricle	HPA Tissue Protein Expression Profiles	1.0	1.14983
SARS-BatSRBD_96Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.63764
GSE111247_14_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RKO	CCLE Cell Line Gene Mutation Profiles	1.0	null
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07739
PMC10140619-mmc5.xlsx-Rank_Beta1-Beta3-Gene_BHLHE22	Rummagene Transcription Factor Associations 2026	1.0	null
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28513
GTEX-QXCU-0008-SM-48FCH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980751
ParietalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.44494
SW403	CCLE Cell Line Gene Expression Profiles	-1.0	-2.00979
Perturb_17642_OE_YAP_SRP298391	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.49839
BRD-K29301364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64372
GSE210580_0_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P4PP-1626-SM-2HMJF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925129
eucatropine-2556	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Ebolavirus(ZEBOV)_7day_PBMCs_rNAPc2treated_21987740_GSE24943	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	0.177621
GTEX-TSE9-0011-R6A-SM-3DB7L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02322
SPI1	ChEA Transcription Factor Targets	1.0	null
mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC6344081-elife-40364-supp5.xlsx-PLZF_peaks_H3K27Ac_unchanged-Unnamed_10_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
ASCL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00402891
GSE89032,GSE89033_0_v_1_sfpq_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
r7 part of the dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61615
BRD-K88498468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.29877
MCF7_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116515
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_60_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K69987634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08426
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05961
primary motor cortex (area M1, area 4)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.824327
GSE70935_1_v_0_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
budesonide-5431	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
layer 6a of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33716
PMC12685885-Table1.xlsx-Table_S9-Du_PanCancer_SOX6_TrsFib_SOX6	Rummagene Transcription Factor Associations 2026	1.0	null
VCAP	CCLE Cell Line Gene CNV Profiles	1.0	1.87245
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.898095
GATA2	ChEA Transcription Factor Targets	1.0	null
GSE97352_3_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
Perturb_16815_OE_HNF1A/FOXA3/PROX1/SIRT1/PGC1A/AMPK_SRP167105	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.12139
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10011
MCF7_AR-42_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0061107
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877536
diprophylline-5063	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC6137108__F3	PFOCR Pathway Figure Associations 2024	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.29384
bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.097777
Anemia, Hemolytic	CTD Gene-Disease Associations	1.0	1.2818
EGFR	Pathway Commons Protein-Protein Interactions	1.0	null
HSF1_01_155	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60572
PMC3461241__F3	PFOCR Pathway Figure Associations 2023	1.0	null
mantle zone of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02682
TemporalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.903863
abnormality of higher mental function	GWASdb SNP-Phenotype Associations	1.0	0.278169
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A6C5-11A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TLDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30881
PMC4450280__F5	PFOCR Pathway Figure Associations 2023	1.0	null
Main olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09335
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0204
NCIH1436	CCLE Cell Line Gene Expression Profiles	1.0	1.42341
Perturb_13600_KD_DDIT3_SRP337871	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.62191
MFE280	DepMap CRISPR Gene Dependency	1.0	2.35664
GSE101239_5_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CC-93-RP38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212359
SIK2	Pathway Commons Protein-Protein Interactions	1.0	null
hiv	GAD Gene-Disease Associations	1.0	null
IgSF CAM signaling	KEGG Pathways 2026	1.0	null
BT-474	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DND41	CCLE Cell Line Gene CNV Profiles	1.0	1.53924
debrisoquin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02664
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.825899
regulated	GeneRIF Biological Term Annotations	1.0	null
Body Weight Changes	CTD Gene-Disease Associations	1.0	1.5181
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.942212
Dinaciclib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.029242
Yersinia infection	KEGG Pathways 2026	1.0	null
regulation of catalytic activity	GO Biological Process Annotations 2015	1.0	null
BRD-A45349889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87647
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32272
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15474
Ovarian Diseases	CTD Gene-Disease Associations	1.0	1.3039
e2f1_21245101_mmtv-myc_lof_mouse_gpl8321_gds4094	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.8167
PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K87781745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94057
RMUGS_OVARY	CCLE Cell Line Proteomics	1.0	2.18875
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.5433
primary auditory cortex (core)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.837971
GR	MotifMap Predicted Transcription Factor Targets	1.0	null
Uterine Neoplasms	CTD Gene-Disease Associations	1.0	1.51355
Primary somatosensory area, upper limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21642
TBX3	ChEA Transcription Factor Targets	1.0	null
PMC10243915-uxad037_suppl_supplementary_table_s1b-table_s3b.pdf-164-ZXDC_ZXDC	Rummagene Transcription Factor Associations 2026	1.0	null
corpus striatum	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE210580_4_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAP2K7	Pathway Commons Protein-Protein Interactions	1.0	null
H4K91ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
activation of mapk activity	GO Biological Process Annotations 2015	1.0	null
autophosphorylation	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal emotion/affect behavior	GWASdb SNP-Phenotype Associations	1.0	0.394963
Main olfactory bulb, outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16854
Wnt Signaling Pathway(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
A549_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165784
SP in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65113
PMC9268799__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3QE-01A-21R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
together	GeneRIF Biological Term Annotations	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Toll Like Receptor 10 (TLR10) Cascade	Reactome Pathways 2014	1.0	null
MAPK targets/ Nuclear events mediated by MAP kinases	Reactome Pathways 2024	1.0	null
HCT8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.9854
BRD-K15924535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78977
Perturb_14287_KD_TENT4A_SRP237261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.03902
rt4	HPA Cell Line Gene Expression Profiles	1.0	1.07003
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.8151
H3K27ac_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-PWO3-0011-R1A-SM-2I5EW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923893
PMC8144624__F5	PFOCR Pathway Figure Associations 2024	1.0	null
whereas	GeneRIF Biological Term Annotations	1.0	null
Epithelial cell signaling in Helicobacter pylori infection	KEGG Pathways 2026	1.0	null
HAX1	Pathway Commons Protein-Protein Interactions	1.0	null
OV7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15091
decreased physiological sensitivity to xenobiotic	MPO Gene-Phenotype Associations	1.0	null
H3K14ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ErbB signaling	WikiPathways Pathways 2024	1.0	null
CRCGN015_MCF10A_48H:N11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29763
TYK-nu	GDSC Cell Line Gene Expression Profiles	-1.0	-1.60928
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SB203580	DGIdb Drug Targets 2026	1.0	0.0377008
PMC6429383__F7	PFOCR Pathway Figure Associations 2023	1.0	null
cortex	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-WL46-0011-R6A-SM-3LK6X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880697
ZNF415	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42291
CRCGN015_HEPG2_48H:B21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28887
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cellular responses to stress	Reactome Pathways 2014	1.0	null
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	CTD Gene-Chemical Interactions	1.0	null
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39604
CDK5	KEA Substrates of Kinases	1.0	null
SARS-CoV_96Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.78909
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4349-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
non-hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.095637
PMC5352059__F4	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K61909412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70202
ZR75_1	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.64227
GSE242290_1_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Primary somatosensory area, lower limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45159
BRD-K70843862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13915
GSE162892_3_v_5_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
jnk1	Phosphosite Textmining Biological Term Annotations	1.0	null
PMC6192166__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE205163,GSE205164_9_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K80622162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36614
QGP1	CCLE Cell Line Gene Expression Profiles	1.0	1.34738
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.695354
molecular transducer activity	GO Molecular Function Annotations 2015	1.0	null
A549_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0222186
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	1.49163
hsa-miR-4694-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.088999
PMC5263239-mmc2.xls-SEM_wt_MLL-Gene_name_1614_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
promoter	GeneRIF Biological Term Annotations	1.0	null
pyelonephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.279011
state	GeneRIF Biological Term Annotations	1.0	null
Perturb_10257_KD_TP53_SRP346937	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-16.3579
BRD-K00816476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67192
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346169
EPHB4	Pathway Commons Protein-Protein Interactions	1.0	null
nucleoplasm	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GSE178113,GSE178116_0_v_1_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X4XX-0011-R3B-SM-46MWK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38918
BRD-K86025005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16249
PMC6461621-41467_2019_9634_MOESM4_ESM.xlsx-Table_S1f-Differentially_expressed_TGFbeta_target_genes_downregulated_in_TFEB_S142A_mutant_tumor_over_vector_FDRp_0_05_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE181959_3_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.50932
NDUFS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07711
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.20052
PKMYT1	Pathway Commons Protein-Protein Interactions	1.0	null
Hematologic Diseases	CTD Gene-Disease Associations	1.0	1.34576
Shigellosis	KEGG Pathways 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4622-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SR-95531-4236	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.898095
Perturb_13919_KD_TARDBP_SRP295809	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.47245
primary somatosensory cortex (area S1, areas 3,1,2)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.847879
PLXND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35443
mitochondrion	GO Cellular Component Annotations 2015	1.0	null
GSE142232,GSE142234_0_v_3_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26749
GTEX-R55E-0011-R9A-SM-2TC6C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85294
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RK-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6417_KO_TP53_SRP274402	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.57058
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.78857
Sarcoma_SARC_TCGA-PC-A5DN-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TP53	Pathway Commons Protein-Protein Interactions	1.0	null
GSE157555,GSE157556_5_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-4104-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF701	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	97.9727
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_52_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
SNG-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_83_KD_HOXC4|HOXC6_SRP192852	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.81625
superficial stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30079
Perturb_9450_OE_SOX9_SRP297132	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.46215
L-Thyroxine (sodium salt pentahydrate)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0274377
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9588458__F7	PFOCR Pathway Figure Associations 2024	1.0	null
PMC5372489__F3a	PFOCR Pathway Figure Associations 2024	1.0	null
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Fc-epsilon receptor signaling pathway	GO Biological Process Annotations 2023	1.0	null
GSE225735_0_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7411
Perturb_6878_KD_LINC00857_SRP371132	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.48414
GTEX-PWO3-0011-R3A-SM-2I5EX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12621
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.897766
Prostate adenocarcinoma_PRAD_TCGA-VP-A87B-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-623	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
BRD-K44368508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0036
Perturb_7930_KD_ZCCHC8/ZFC3H1_SRP222099	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.54822
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51435
BRD-K21443215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.47161
mammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16707
BRD-K35196805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02878
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890086
BRD-K37564297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24947
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_32_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_103_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
A549_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00983208
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.988593
PMC7062835__F1	PFOCR Pathway Figure Associations 2024	1.0	null
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.863673
SHTN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00625167
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.05516
hsa-miR-301a	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
GSE160083,GSE160084_2_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
MAPK signaling	WikiPathways Pathways 2024	1.0	null
Apoptosis(Mus musculus)	WikiPathways Pathways 2014	1.0	null
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.934923
regulation of signal transduction	GO Biological Process Annotations 2015	1.0	null
Perturb_14051_OE_NFIB_SRP281947	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.18002
BRD-K31348453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46275
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.62835
GAMG	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34341
BRD-K37763427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11337
primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047464
hsa-miR-454	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4397
involvement	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7579-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9314667-Table_1.xlsx-Regulons-IRF4_IRF4	Rummagene Transcription Factor Associations 2026	1.0	null
MED16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36165
PMC3164671__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Fibrosis	CTD Gene-Disease Associations	1.0	1.90509
GTEX-S7SE-0011-R2A-SM-2XCDC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00943
(+)-isoprenaline-3384	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215867
periventricular stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42044
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-A4BW-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.2726
Mouth Neoplasms	CTD Gene-Disease Associations	1.0	1.22979
ifosfamide-3485	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K86358396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44127
Insulin signaling pathway	KEGG Pathways 2026	1.0	null
GSE128634,GSE128636_2_v_0_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
clofazimine-5642	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K01285236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75279
PMC6070710__F11	PFOCR Pathway Figure Associations 2024	1.0	null
GSE215351,GSE215794_1_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.1713
Lymphoma	CTD Gene-Disease Associations	1.0	1.02447
Primary somatosensory area, barrel field, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54304
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52273
GSE114690_2_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K42008693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16533
primary auditory cortex (core)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10389
Chromosomal and microsatellite instability in colorectal cancer 	WikiPathways Pathways 2024	1.0	null
Perturb_9061_KD_NANOG_SRP100928	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.34352
GATA3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68078571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.58359
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52273
abnormal motor coordination/ balance	MPO Gene-Phenotype Associations	1.0	null
SP600125	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
BRD-K17259076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31597
Perturb_14178_KO_CD33/CD123_SRP387539	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.92387
MF-11-EW49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.385186
SUM159PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.552968
GTEX-W5X1-1426-SM-3GIKH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867484
mantle zone of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33716
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71392
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BM-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868744
Perturb_12028_OE_ID3_SRP333901	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.30352
GSE212312_1_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_9095_KD_SMARCA4_SRP293297	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.14148
Immune System	Reactome Pathways 2024	1.0	null
PMC7291745-12967_2020_2407_MOESM2_ESM.xlsx-Table_S1D_CCF_pairs-locus_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
DMS153	CCLE Cell Line Gene Expression Profiles	1.0	1.79902
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Omeprazole (sodium)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0474957
regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
Taenia tecta, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11236
superficial stratum of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25413
ethoxyquin-3846	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal hematopoietic system morphology/development	MPO Gene-Phenotype Associations	1.0	null
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K67702605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02399
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41P-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Norepinephrine	CTD Gene-Chemical Interactions	1.0	null
TNK1	Pathway Commons Protein-Protein Interactions	1.0	null
AR-27623747-22RV1-MOUSE-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K23825243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06759
Multiple Myeloma	CTD Gene-Disease Associations	1.0	1.24905
GSE123372,GSE123373_1_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
piroxicam-1405	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PK-45H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33976
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K82217056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02553
CDK1	Hub Proteins Protein-Protein Interactions	1.0	null
MCF7_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147242
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14397
GTEX-NPJ7-0011-R10A-SM-2I3E5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67966
PMC4626177__F7	PFOCR Pathway Figure Associations 2023	1.0	null
GSE211983_1_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6935-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
protein modification process	GO Biological Process Annotations 2015	1.0	null
SRY	JASPAR Predicted Transcription Factor Targets	1.0	null
Erythema	CTD Gene-Disease Associations	1.0	1.1198
PCI-15A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-QA-A7B7-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HW-7489-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K76910883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88063
Perturb_5646_KD_LOXHD1_SRP298159	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.79972
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AW-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051035
Alzheimer 39 s disease and miRNA effects	WikiPathways Pathways 2024	1.0	null
GSE111660_1_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Toll Like Receptor 7/8 (TLR7/8) Cascade	Reactome Pathways 2024	1.0	null
Abiraterone acetate_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0333654
GSE206093,GSE206094_1_v_3_isl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
iloprost-488	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cerebellum	HPA Tissue Protein Expression Profiles	1.0	1.37853
GTEX-QVUS-0011-R6A-SM-3GACX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937387
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ask1mkk4jnk3	GeneRIF Biological Term Annotations	1.0	null
CRCGN015_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1784
Nephrin/Neph1 signaling in the kidney podocyte	PID Pathways	1.0	null
cone	GeneRIF Biological Term Annotations	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18576
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.6664
Lung squamous cell carcinoma_LUSC_TCGA-33-A5GW-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5878-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R53T-0005-SM-3GADK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86173
nizatidin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17639
hematopoietic system phenotype	MPO Gene-Phenotype Associations	1.0	null
BRD-K38118311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42505
Perturb_8471_Mut_IDH1_SRP099826	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE147366_1_v_4_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q2AG-0011-R11A-SM-2HMKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947121
striatum_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2026
GSE223893_2_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.936359
GTEX-X4XX-0011-R8B-SM-46MWM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05004
BRD-K83786559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77223
Adenocarcinoma	CTD Gene-Disease Associations	1.0	1.64348
flunisolide-3747	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
amikacin-1618	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:O16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40805
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26752
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17941
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30722
Primary somatosensory area, mouth, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61726
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-GENE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K60188481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62638
Interleukin-17 signaling	Reactome Pathways 2024	1.0	null
kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.057722
GTEX-O5YV-0008-SM-4E3HP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.871792
MyD88 cascade initiated on plasma membrane	Reactome Pathways 2014	1.0	null
Mammary Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.24244
decreased neuron apoptosis	MPO Gene-Phenotype Associations	1.0	null
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.63647
MCF7_Mocetinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00822354
GSE157555,GSE157556_0_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC4533315__F3	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K60623809_SU11652_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Diseases	CTD Gene-Disease Associations	1.0	1.06044
PMC7247338__F3	PFOCR Pathway Figure Associations 2023	1.0	null
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.70186
Oxidative Damage(Mus musculus)	WikiPathways Pathways 2014	1.0	null
crohn's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.357077
GSE135030_8_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
HNRNPK	Hub Proteins Protein-Protein Interactions	1.0	null
BRD-K22915992	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04973
CRCGN017_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.57705
Betamethasone dipropionate_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0231387
BRD-K30795375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08536
PMC10534007-Table_2.xlsx-S4_unique_down_MSC_V-745_elements_included_exclusively_in_VM-CUB1_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE175787_11_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.89221
GSE229468,GSE229471_2_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4477b	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
fulvestrant-704	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CRCGN017_MCF10A.WT.HP_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3619
Tranilast_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00706045
GTEX-P44H-0011-R8A-SM-2XCEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.017
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.984825
BRD-K84741596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29284
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.72181
GSE211931_2_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.945137
intermediate part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20347
CRCGN017_MCF10A.WT.HP_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5329
epithelial cell signaling in helicobacter pylori infection	KEGG Pathways	1.0	null
Cervix - Endocervix	GTEx Tissue Gene Expression Profiles 2023	1.0	2.25962
jnk3	GeneRIF Biological Term Annotations	1.0	null
GSE145915_3_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PTPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64186
BRD-K47212522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13207
COLO775	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45579
TP53	Hub Proteins Protein-Protein Interactions	1.0	null
hsa-miR-137	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921183
Apoptosis Modulation by HSP70(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
PMC12209767-bcd-25-0099_supplementary_table_s2_suppst2.xlsx-C_DEGs_RNA-seq-Supplementary_table_S2C_List_of_differentially_expressed_genes_in_IGHUND_vs_IGH_GCB_MB2_DE_DLBCL_HGBCL-DH-BCL2_-BCL6_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54E-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
betulinic acid-4181	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_7356_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.54329
Activation of the AP-1 family of transcription factors	Reactome Pathways 2024	1.0	null
GSE111660_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.58179
akt1	Phosphosite Textmining Biological Term Annotations	1.0	null
Primary visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.73512
SERPINB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31701
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_6_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Down Syndrome	DisGeNET Gene-Disease Associations	1.0	null
Measles virus infection	WikiPathways Pathways 2024	1.0	null
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925863
PP2	DGIdb Drug Targets 2026	1.0	0.0363544
CTPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03717
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1581
hsa-miR-759	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
regulation of protein kinase activity	GO Biological Process Annotations 2015	1.0	null
EXTL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17328
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65276
BRD-K61595867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46762
GSE229468,GSE229471_0_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
14583454-TableS2	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8512-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K26634905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.36333
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6931
INA6	DepMap CRISPR Gene Dependency	1.0	4.43459
sublayer 6a of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32752
CMK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.50421
Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KR-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30548577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.35986
Alzheimer disease-amyloid secretase pathway	PANTHER Pathways	1.0	null
RALDH2_KO_GSE43578_6_mouse_head (rostral or posterior)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
superficial stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76305
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825365
GTEX-P44H-0011-R4A-SM-2XCEW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.882852
regulation of map kinase activity	GO Biological Process Annotations 2015	1.0	null
BRD-K16885048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21664
Lung squamous cell carcinoma_LUSC_TCGA-94-8490-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A02612852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2907
APP	Hub Proteins Protein-Protein Interactions	1.0	null
Respiratory Distress Syndrome, Adult	CTD Gene-Disease Associations	1.0	1.17431
GSE215351,GSE215794_2_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K98190019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06424
GSE240444_2_v_3_idasanutlin_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08207
A549_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192689
IM9	DepMap CRISPR Gene Dependency	1.0	4.55048
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4340-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE261563_9_v_8_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PAMAPIMOD	DGIdb Drug Targets 2026	1.0	0.203585
depression	GWASdb SNP-Phenotype Associations	1.0	0.660775
SHC1	Hub Proteins Protein-Protein Interactions	1.0	null
PMC8036964__F7	PFOCR Pathway Figure Associations 2023	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-QM-A5NM-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051321
PMC8576247__F4	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-QVJO-0011-R1A-SM-2S1QI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28131
mononuclear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06726
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41861
Retrosplenial area, lateral agranular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04654
macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.253578
PMC8120022-CTM2-11-e420-s006.xlsx-Sheet1-Table_S1_786_altered_genes_involved_in_cancer-related_pathway_in_TMPRSS2_ERG_fusion-positive_prostate_cancer_Genes_involed_in_multiple_pathways_are_duplicated_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47784292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83197
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.924802
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7245-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
basal	GeneRIF Biological Term Annotations	1.0	null
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849271
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A14424697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39127
BRD-K93153656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62463
RCOR1-19997604-NEURONS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MAPK cascade	GO Biological Process Annotations 2025	1.0	null
GnRH signaling pathway	KEGG Pathways 2026	1.0	null
BRD-K83477969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15982
PAK3	Pathway Commons Protein-Protein Interactions	1.0	null
phenyl-aminosalicylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73952
JUN-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Main olfactory bulb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36188
EBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03125
hsa-miR-3714	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
EZR	Pathway Commons Protein-Protein Interactions	1.0	null
DUSP8	Pathway Commons Protein-Protein Interactions	1.0	null
Brain_Hippocampus_Middle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.16326
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31877
GSE155031_5_v_3_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52273
BRD-K77697725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10141
H3K27me3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.54957
teratocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.141405
brinzolamide-5016	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.434
Reactive Oxygen Species	CTD Gene-Chemical Interactions	1.0	null
Retrosplenial area, dorsal part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27979
GTEX-NL4W-0011-R6a-SM-2I3GA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881527
GTEX-NL3H-0011-R5a-SM-2I3GB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872608
CD40	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-222	TargetScan Predicted Conserved microRNA Targets	1.0	0.092495
dorsal motor nucleus of the vagus (vagal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19843
Potassium Chloride	CTD Gene-Chemical Interactions	1.0	null
DNA Damage Response (only ATM dependent)(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53919
hsa-miR-4514	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
Perturb_10002_KD_FTO_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.79905
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K60781525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25765
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041724
PMC7422534__F4	PFOCR Pathway Figure Associations 2023	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-8261-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1	Reactome Pathways 2024	1.0	null
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20405
subtle	GeneRIF Biological Term Annotations	1.0	null
GTEX-PWO3-0011-R5A-SM-2I5EZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859615
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
adult retina	HPM Cell Type and Tissue Protein Expression Profiles	1.0	1.14787
PMC7806950-mmc2.xlsx-SET_Significant-DEGs-Table_S2_Significant_DEGs_following_targeting_of_dSaCas9-repressors_to_DUX4_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
UM-UC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.076667
IFNG	Pathway Commons Protein-Protein Interactions	1.0	null
abnormal cell physiology	MPO Gene-Phenotype Associations	1.0	null
PMC5444746-oncotarget-08-30328-s002.xlsx-SI01_ChIPSeq_H3K9me_AR-Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.05185
required	GeneRIF Biological Term Annotations	1.0	null
BRD-K04562748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02812
MCF7_Tucidinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136299
anion binding	GO Molecular Function Annotations 2015	1.0	null
Perturb_5390_KO_TYK2_SRP350422	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.09524
acts	GeneRIF Biological Term Annotations	1.0	null
LY2090314_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0594148
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.42949
PTK2B	Pathway Commons Protein-Protein Interactions	1.0	null
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K96106084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67996
LTBR_INHIBITION - 2 Days_GDS2005_729_mouse_Lymph nodes  (MG-430B)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PMC10140619-mmc5.xlsx-Beta3_ConVsBSL-Gene_BHLHE22	Rummagene Transcription Factor Associations 2026	1.0	null
posteroventral (inferior) parietal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.52784
toll-like receptor 2 signaling pathway	GO Biological Process Annotations 2015	1.0	null
vascular endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.091541
UBE2D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15534
parasitic infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047921
Perturb_980_OE_NANOGP8_SRP065951	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.10243
CB-69-KJ83_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23162
PMC7368075__F2	PFOCR Pathway Figure Associations 2023	1.0	null
inner CP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.836304
BRD-K86893953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7506
Perturb_9094_KD_SMARCA4_SRP293297	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.91818
GSE166315_1_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Pleural mesothelioma	WikiPathways Pathways 2024	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SA-01A-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SYK	Pathway Commons Protein-Protein Interactions	1.0	null
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
16081686-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
metoclopramide-3625	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cercopithecus-aethiops	Phosphosite Textmining Biological Term Annotations	1.0	null
SUDHL5	CCLE Cell Line Gene Expression Profiles	1.0	1.89628
Lung adenocarcinoma_LUAD_TCGA-44-7659-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Burkitt Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-4692	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
MCF7_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152526
Bed nuclei of the stria terminalis, posterior division, transverse nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18845
BRD-A68175400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13705
GTEX-PLZ4-2726-SM-3P61A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861805
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040362
Perturb_545_KD_CT_SRP201842	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.91864
enzyme-inhibitors	Phosphosite Textmining Biological Term Annotations	1.0	null
GSE87617_1_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_17804_KD_NUDT21_SRP238933	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.76866
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.938277
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
Rucaparib (phosphate)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00651901
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05007
Benztropine (mesylate)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00542991
Liver Failure	CTD Gene-Disease Associations	1.0	1.18326
GSE121824,GSE121826_0_v_6_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4451	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-K83143868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38877
BRD-K72296840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38175
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A1HT-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
survival	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875798
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.22016
GTEX-PWOO-0826-SM-48TCL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961596
hsa-miR-3612	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38304
Apoptosis modulation by HSP70	WikiPathways Pathways 2024	1.0	null
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.3103
pneumonia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.087395
GSE77178_5_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K62193937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08483
Placenta	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.431
GSE203158_5_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A9FL-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K73227539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28931
PMC9437808-mmc3.xlsx-IPA_Upstream_regulators-IPA_Upstream_regulator_analysis_Up_regulated_genes_following_LPS_treatment_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PPARG	JASPAR Predicted Transcription Factor Targets	1.0	null
Infigratinib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0233704
MCF7_M344_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00783924
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959293
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.869308
Pathogenic Escherichia coli infection	KEGG Pathways 2026	1.0	null
Pathways of neurodegeneration - multiple diseases	KEGG Pathways 2026	1.0	null
AGE-RAGE signaling pathway in diabetic complications	KEGG Pathways 2026	1.0	null
jnk	Phosphosite Textmining Biological Term Annotations	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H4-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K87080069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.51147
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
hESC_Derived_CD56+_Ectoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.13051
PMC2858611__F3	PFOCR Pathway Figure Associations 2023	1.0	null
Insulin Resistance	CTD Gene-Disease Associations	1.0	1.13793
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.083707
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.126168
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.28499
cAMP signaling pathway	KEGG Pathways 2026	1.0	null
nefopam-3627	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
regulation of cellular macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GTEX-R55E-0006-SM-2TC5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1323
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC6008200__F7	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K44483161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34369
GSE110580_1_v_0_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17682
Adenosine triphosphate	HMDB Metabolites of Enzymes	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-2692-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
alzheimer disease	GWASdb SNP-Phenotype Associations	1.0	0.481449
Sarcoma_SARC_TCGA-DX-A48O-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
flufenamic acid-5059	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE238005_0_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.091541
SJSA-1	GDSC Cell Line Gene Expression Profiles	1.0	1.49761
phosphorylation	GO Biological Process Annotations 2023	1.0	null
BRD-K22800340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74689
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32654
Perturb_2388_KO_CARM1_SRP333775	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.90263
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849678
GSE205163,GSE205164_5_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of response to stress	GO Biological Process Annotations 2015	1.0	null
ZBTB18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00794
CTCF_fibroblast of lung_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82883803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14697
AOB, internal plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.15492
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6962-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6423_KD_LOC646329_SRP220725	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.36848
Retrosplenial area, lateral agranular part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0279
Prolactin signaling pathway	KEGG Pathways 2026	1.0	null
orlistat-6388	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cotinine-2011	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mRNA_ZFAND3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K4me1_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
brain	GTEx Tissue Gene Expression Profiles	1.0	1.30762
CRCGN016_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13236
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.773
Brain derived neurotrophic factor BDNF signaling	WikiPathways Pathways 2024	1.0	null
GTEX-QDT8-0011-R2A-SM-32PKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06775
Arsenates	CTD Gene-Chemical Interactions	1.0	null
hsa-miR-1224-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.175726
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Danusertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110528
molecular	GeneRIF Biological Term Annotations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6148-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cyclosporin A_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0247354
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
MAP3K7CL	Pathway Commons Protein-Protein Interactions	1.0	null
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-613	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.39555
FOSL2_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OXIDOPAMINE	DGIdb Drug Targets 2026	1.0	0.135723
SLITRK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21096
DES_KO_GDS4804_171_mouse_young skeletal muscles	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
haloperidol-2704	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K98625375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18273
Glioblastoma	CTD Gene-Disease Associations	1.0	1.25121
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K93316985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15914
YAP1	ChEA Transcription Factor Targets	1.0	null
hsa-miR-22	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
ATN1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95051
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16911
Noncanonical Wnt signaling pathway	PID Pathways	1.0	null
amygdaloid complex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.31689
phosphatase	Phosphosite Textmining Biological Term Annotations	1.0	null
TESK2	Pathway Commons Protein-Protein Interactions	1.0	null
ErbB2/ErbB3 signaling events	PID Pathways	1.0	null
BRD-K03093950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74985
outer plexiform zone in extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19399
MAPK8	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5546-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7527_KO_EED_SRP239128	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Retrosplenial area, ventral part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64266
UBF1/2-26484160-CHIP-SEQ-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
obstructive lung disease	GWASdb SNP-Phenotype Associations	1.0	1.34749
lymecycline-7291	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.828197
CRK	Hub Proteins Protein-Protein Interactions	1.0	null
MCF7_PCI-34051_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134836
ATP6V1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07309
Lung adenocarcinoma_LUAD_TCGA-O1-A52J-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K45609222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32944
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117534
GTEX-WZTO-0011-R11A-SM-4E3K9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862896
BRD-K56729241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18024
BRD-K38248167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78728
PMC4605373__F4	PFOCR Pathway Figure Associations 2024	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1736
epiandrosterone-3306	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1771
impaired coordination	MPO Gene-Phenotype Associations	1.0	null
Perturb_10234_KO_FAM120A_SRP384156	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.37378
hsa-miR-1	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Toll Like Receptor TLR1:TLR2 Cascade	Reactome Pathways 2024	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A42L-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAP4K5	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12748338-12672_2025_4052_MOESM1_ESM.docx-0-KLF9_KLF9	Rummagene Transcription Factor Associations 2026	1.0	null
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36241
cytochrome	Phosphosite Textmining Biological Term Annotations	1.0	null
GSK1059615_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0629866
cellular process	GO Biological Process Annotations 2015	1.0	null
PMC8384902-mmc5.xlsx-H128_PROX1_ChIP-Symbol_PROX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K91039552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87951
PMC4772274__F2	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87461
Circadian rhythm genes	WikiPathways Pathways 2024	1.0	null
Perturb_289_KO_PHF8_SRP399627	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.79898
Proteinuria	CTD Gene-Disease Associations	1.0	1.92359
JNK INHIBITOR V	DGIdb Drug Targets 2026	1.0	1.01792
A-673	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32438
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE216988,GSE216989_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
asthma	GAD Gene-Disease Associations	1.0	null
SKMEL5_SKIN	CCLE Cell Line Proteomics	1.0	2.86106
positive regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
Toll Like Receptor 5 (TLR5) Cascade	Reactome Pathways 2014	1.0	null
BRD-K92974694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27995
type ii diabetes mellitus	KEGG Pathways	1.0	null
molsidomine-1711	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.35189
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.84768
SBI-0640756_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0209051
seizures	MPO Gene-Phenotype Associations	1.0	null
PMC4051800__F6	PFOCR Pathway Figure Associations 2023	1.0	null
GSE217363_4_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.518095
substantianigra	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23067
Perturb_9988_KD_CNOT7_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.02365
12925741-Figure10	GeneSigDB Published Gene Signatures	1.0	null
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.248683
Perturb_10399_OE_LINC00339_SRP302179	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.48333
Lingula (I), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62645
GTEX-Q2AG-0011-R5A-SM-2HMJH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02335
Multiple sclerosis	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.509691
Rheumatoid Arthritis	DisGeNET Gene-Disease Associations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KC-A4BV-01A-31R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lymphnode_4a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.902948
Lung squamous cell carcinoma_LUSC_TCGA-22-4591-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XMD1-0011-R5A-SM-4AT47	GTEx Tissue Sample Gene Expression Profiles	1.0	0.970383
Perturb_12314_KO_AGO1_SRP136692	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.9565
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.351923
Perturb_15827_OE_Nrf2_SRP291724	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.8274
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GATA3_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153757,GSE153758_1_v_3_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R55F-0011-R8A-SM-2TF4F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988432
GSE216540_1_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_12316_KD_CDKN1B_SRP136720	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.54342
NEK11	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K03902845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01971
Perturb_8054_KD_IGF2BP1_SRP094100	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.0224
Cervix Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K16355056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07494
Primary motor area, Layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16108
PMC10534007-Table_3.xlsx-S8_unique_down_MSC_V-345_elements_included_exclusively_in_VMCUB1_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.34072
Sarcoma_SARC_TCGA-K1-A42X-02A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FLNA	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4271	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
TCF12_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144231_2_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
protein serine/threonine/tyrosine kinase activity	GO Molecular Function Annotations 2025	1.0	null
BRD-K82107155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21315
LAMA1	Pathway Commons Protein-Protein Interactions	1.0	null
Eeg With Focal Sharp Slow Waves	DisGeNET Gene-Phenotype Associations	1.0	null
ESR1-30970003-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.40948
pathology	Phosphosite Textmining Biological Term Annotations	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2955-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
CRCGN008_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0059