association	dataset	threshold value	standardized value
preweaning lethality, incomplete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
Osteoblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.533
BRD-K03546460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58698
GSE250534_2_v_3_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K09071517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2073
SCF ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.401
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.6817
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ERMES complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.798
BRD-K61651560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.32056
Inner mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.961
BRD-K67337799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8254
BRD-K75416889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06294
SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9025
GSE60217_1_v_2_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
BRD-K71357636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50635
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.855804
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.096
PMC6080909-JEM_20171312_TableS1.xlsx-Each_THP1_Pulldown_Expt_Targets-Unnamed_1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.789
DEDD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00813062
BRD-K26734305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01389
MCF7_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136182
A549_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146449
PMC11684804-jci-135-174981-s193.xlsx-DESeq2_pseudobulk_AA_Ag_vs_Pre-Gene_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K50177531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15437
BRD-K52152765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20343
Lewy body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.473
BRD-K46970272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54339
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.123
BRD-K58971526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97784
Chronic progressive external ophthalmoplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
HOPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.765
BRD-K89063617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73931
K562_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154872
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.671
Parkinson's disease 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.948
MCF7_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013246
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEx Heart 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-3.48976
MCF7_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01763
GSE77108_8_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A40010674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06846
SYNRG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5263
BRD-K92891227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01548
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
colo680n	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.561
BRD-K21660570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45172
SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	4.20851
BRD-K79221878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01894
FAM210B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0463
8661_TAF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20239
ZNRF3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00550202
A549_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015136
PMC10274745-media-4.xlsx-S3A-Table_S3_Reanalysis_of_publicly_available_data_to_identify_AR_and_ER_direct_target_genes_related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04568082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06722
GSE217363_5_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
8905_TIFA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.633118
BORCS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15861
K562_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151495
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_10_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.07209
Mitochondrial envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.562
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Arteriosclerotic cardiovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
GSE110440_2_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_5_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE104022_3_v_7_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8802
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_UP_NR2F1_ind_UP-NR2F1_Ind_UP_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K56261053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24662
GSE178340_5_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-S_72h_2-up-regulated_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE238116_1_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Rough endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.924
BRD-K14589361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65045
BRD-A64957606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28095
GSE184892_6_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210476_2_v_5_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K13526564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55485
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8331
655_ATP5F1C_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24303
BRD-K37780492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17576
Organellar ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.216
FAM98B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38462
GSE231648_0_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Vandetanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166993
MICOS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.605
GSE178340_1_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.0941
VSIG10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00508813
GSE193993_1_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Immunodeficiency 33	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
A549_Regorafenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167314
BRD-K85513337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0106
BRD-K61310138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04782
BRD-K60932633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39045
Proteasome accessory complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.973
ARHGEF3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00568566
Microbody lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.152
BRD-K29771129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49994
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TNFRSF1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00623128
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K19652287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68499
GSE249544,GSE249637_9_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEx AdiposeTissue 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	-1.0	-6.30591
GSE114992,GSE114993_7_v_10_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2203_DHX15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.745613
GSE121198,GSE129782_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_0_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.16
A549_Divalproex Sodium_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149003
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K39318389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01678
GSE206870,GSE206872_1_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133087_5_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11687
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TAOK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2483
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.772
B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.306
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131861
GSE119564_1_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145872
GSE168596_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166004_7_v_0_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211989_3_v_2_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Dermatofibroma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.564
GSE201042_2_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K38434557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04315
GSE242199_2_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178255_1_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HL-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.998
magnesium-dependent protein serine/threonine phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.665
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.0536
BRD-K01478290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20316
TIMM10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11606
GSE203655_0_v_1_stat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Substantia nigra	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.505
Optic nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.889
NCIH2126_LUNG	CCLE Cell Line Proteomics	1.0	2.9198
BRD-K72468471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14994
positive regulation of mitochondrial fission	GO Biological Process Annotations 2025	1.0	null
BRD-K10160311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42817
GSE77178_6_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207787_1_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Arm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.002
GSE152432_1_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31459
PANK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00784515
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.596
Cardiomyoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.789
PMC5668942-supp_gr.216721.116_Supplemental_Data_S2.xlsx-Artery_Tibial_IR-TE-SRCAP_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_PHA-680632_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0118458
BRD-K39223685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60022
BRD-K69348766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93307
CRCGN016_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42745
EPHB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532315
BRD-K47443098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8709
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.783
BRD-K75583553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72382
Dopaminergic neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.641
GSE201239_3_v_2_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K56618252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81772
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
PMC9992472-41467_2023_36735_MOESM5_ESM.xlsx-SOX11_OE_9h_in_SH-EP-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A86415025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1014
GSE196117_6_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9883
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VPS18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.419
NDST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.797
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6747
GSE62843,GSE64371_4_v_0_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
early-onset Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.868
BRD-K38853406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9397
BRD-K46560430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18406
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.392
MCF7_Hesperadin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128573
Ire1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.25
MTG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45037
t69-brown-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.99643
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
GSE220520_5_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
ERCC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88973
CRCGN011_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3756
GSE152379_0_v_4_bach2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K87277021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06141
ELAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13599
GSE158834_0_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bounding membrane of organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.559
BRD-A73559168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40441
BRD-K45908502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37434
GSE196671_6_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.59819
BRD-K84790105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14074
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
BRD-K14925361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2129
Omegasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.175
BRD-K09693670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62261
PMC5193459-pone.0168968.s009.xlsx-Dharmacon_OTP_siRNA_Area-Symbol_OTP	Rummagene Transcription Factor Associations 2026	1.0	null
GSE179880_10_v_3_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.149
BRD-K01045229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14774
Atherosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
BRD-K50367303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20155
BRD-K71501826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41168
BRD-K57388326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74937
Proteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.305
BRD-K07802542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25924
BRD-K93442068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00271
CTCF-33576154-HUMAN-PERIGASTRICLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K32839286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73085
BRD-K50210179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50903
CRCGN010_HEPG2_24H:E11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03163
GSE165122_0_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC16A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17859
BRD-K67832115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23188
BRD-K91779437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23351
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.321
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
organelle outer membrane	GO Cellular Component Annotations 2023	1.0	null
PMC11380310-adr-8-adr240062-s002.xlsx-blood_eQTL_MR_results-Gene_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017755
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199606_3_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10353
FOXJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20586
GSE240027,GSE240030_5_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:B24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07037
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
AHR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00391923
protein autoubiquitination	GO Biological Process Annotations 2025	1.0	null
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
GSE148066,GSE157787_5_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RDH12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00557538
GSE133213_6_v_13_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31325
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
GSE186707_1_v_0_hdac4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Parkinsonism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.514
GSE248045,GSE248046_0_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133899
GSE248887_0_v_1_dkk1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.647
CRCGN011_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.229
SUGT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0077357
Spleen	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.23717
CRCGN008_HEPG2_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42775
BRD-K77252933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97734
C17orf80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81959
AF4-26711339-SEM-HUMAN-BLOOD-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K60948317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03967
GSE192362_1_v_0_erastin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HPGDS-In1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K67522096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01675
BRD-K92356505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07242
BRD-K78574327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33136
Chang cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.015
GSE157777_2_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K74916896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03512
Pyruvate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.197
GSE162688_3_v_4_pink1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K32988853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11186
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8979909-13353_2022_690_MOESM1_ESM.xlsx-ESR1_targets-genes_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K25791914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48146
GSE124375_13_v_12_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Dilated cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
decreased body weight	MGI Mouse Phenotype Associations 2023	1.0	null
GSE136894_1_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Finger	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.02
MCF7_Pelitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110969
GSE185944_5_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial DNA depletion syndrome 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7684
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K34277236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33707
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141675
BRD-K75584297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25225
BRD-K83818372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14253
Endosomal scaffold complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.706
BRD-K42529194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32692
SERPINE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00759907
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.9381
GSE254517_3_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K23430405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75199
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196122
Mitochondrial nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.078
MCF7_Alisertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145332
GSE160246_0_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K07484899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24747
GSE182680,GSE182683_10_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K69668687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12557
Genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.506
BRD-K69350885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03918
BRD-K89216747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54493
Adrenal Gland	GTEx Tissue Gene Expression Profiles 2023	1.0	1.22732
GSE149901_3_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35167
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.650221
BRD-K29549246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44443
GSE161064,GSE161065_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146074_0_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K63401627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63268
MCF7_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183224
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K53491881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00204
BRD-K40494117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75216
GSE65617_2_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K75514760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7261
BRD-K97929312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05841
GSE158834_10_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Intrinsic component of peroxisomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.795
BRD-K30910725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33954
10348_ZNF423_ENST00000262383.2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.859607
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K98145661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21575
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5916961__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE182680,GSE182683_5_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.399
MCF7_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144818
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CPEB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67631
GSE148066,GSE157787_0_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.684
BRD-K85392247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7399
Cervical adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.062
BRD-K92359570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14848
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K22071228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07618
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10259508-jciinsight-8-166698-s009.pdf-10-DPF1_DPF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K16154498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34979
GSE166317_2_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K73692505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57703
BRD-K68558540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23479
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4169
chr10_92184585_T_C_b38	GTEx eQTL 2025	1.0	1.24972
A549_Avagacestat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158383
BRD-K22510845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78608
ERBIN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0056421
BRD-K36464765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16643
STT3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04603
BRD-K26748243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68782
SAM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.14
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.567
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
3537_GRINA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.98911
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.30046
BRD-K28006645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03772
BRD-K64182862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05562
A549_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143256
SPCS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18153
GSE148066,GSE157787_3_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K29547381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67969
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.502207
BRD-K86750448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27605
GSE235682_3_v_0_rbl2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139948_3_v_6_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Pulmonary artery smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.724
Mitochondrial permeability transition pore complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.784
BRD-K90877053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00371
GSE158834_10_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-MECP2-fromNode_MECP2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K58270905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20745
GSE76771_2_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K99277076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26283
BRD-K89931949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05937
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
GSE189683_3_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A53381587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11586
GSE254517_1_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE127790_6_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Curcumin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181641
GSE211983_0_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.4
DCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.89546
GSE143212_0_v_3_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE224969,GSE224971_0_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10274973-media-3.xlsx-ST18-Supplementary_Table_18_476_Bonferroni_significant_results_P_2_67_x_10-6_of_gene_based_association_analyses_H-MAGMA_dlPFC_cortical_neurons_for_sensation_seeking_factor_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K84246050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27576
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K08806664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07983
BRD-K87264606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68071
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:D21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20719
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K89805341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1229
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173184
BRD-K01096898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04251
GSE147943_4_v_6_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195582_3_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K16136457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88459
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.58
PMC8040704-jcav12p2673s2.xlsx-Down-regulated_genes_in_EBF1-Unnamed_0_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
Myoblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.523
GSE211126_3_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K72591075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57154
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
Cell envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.049
BRD-K71298594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03077
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	1.0	null
HAUS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31828
PMC12629827-mmc8.xlsx-DDR2_KD-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114992,GSE114993_7_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K47409867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.5111
BRD-K96596828	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51637
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4954
GSE180277_0_v_1_bach2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01726
TMA16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31752
GSE58724_3_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.091
8126_SLU7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.72602
BRD-K78311779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77949
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	66.9722
BRD-K60837711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0057
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.199
A549_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167744
GTPase binding	GO Molecular Function Annotations 2025	1.0	null
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.508187
BRD-K35848924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55353
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
BRD-K95863777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2075
HEC6_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	2.07363
1408_CDC5L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.708499
BRD-K69987634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20895
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.57
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4204
BRD-K34815008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07571
BRD-K12411112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01533
BRD-K51754677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14138
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.48173
BRD-K63813316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87628
Glucose metabolism disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.506
A549_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215962
BRD-K05549579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03697
BRD-K39715006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53461
CRCGN008_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2154
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.475
MCF7_Ivosidenib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130806
Mitochondrial myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.46
BRD-A70099008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96565
HCMEC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.63
BRD-A12372458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41741
BRD-K43224838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11841
BRD-K20236423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18715
GSE126463_1_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66422
Intrinsic component of organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.489
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.2647
URI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64152
BRD-K22308901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46089
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11625057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16212
GSE148066,GSE157787_8_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
increased circulating interleukin-6 level	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K39962926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59833
BRD-K68083867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38295
GSE125014_1_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0382
NGLY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17381
6863_PSMC6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08858
ZNF461	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31078
BRD-K30358777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10157
Uterus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.27
GAMG_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	3.95782
Integral component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.751
BRD-K95927760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11982
BRD-K41649962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11271
Flight muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.385
ARL16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13582
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.26979
NES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05906
BRD-K84939696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52292
10029_ZC3H8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.16783
BRD-K13973870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18354
Respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.309
SNU423_LIVER	CCLE Cell Line Proteomics	1.0	2.57017
BRD-K51322795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51921
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145311_1_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Ktp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.012
BRD-K89065802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50011
Throat	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.363
i-AAA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.868
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.81008
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Flumatinib (mesylate)_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0168116
PMC7468443-Data_Sheet_5.xlsx-LPS_2h_over_6h-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166169_1_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H9c2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.592
PMC9574515-mmc2.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
Smooth endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.199
KCNK7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00487842
BRD-K53752646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17266
GSE206870,GSE206872_0_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RBM8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62017
SOD1-Bcl-2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.674
GSE102870_11_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.686
GSE205163,GSE205164_1_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EDEM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57708
GSE122067_3_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174098
GSE250534_0_v_3_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
BRD-K35668999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00959
GSE222758_0_v_4_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
10442_ZNF554_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.83603
GSE162739_6_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hyperglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
Familial encephalopathy with neuroserpin inclusion bodies	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
PMC12047497-mmc5.xlsx-Sheet1-GSE20754_WT_VS_TCF1_KO_MEMORY_CD8_TCELL_UP_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64451677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.564
GSE77178_1_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.4873
VPS45	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00494832
BRD-K26423054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20412
GSE98964_0_v_2_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K28140275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72955
GSE223908,GSE223909_4_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Wing	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.108
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Enzastaurin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146151
BRD-K73027631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.65562
MCF7_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132146
RAB3GAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88741
496100645_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11855
GSE152441,GSE152442_1_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210580_4_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Organelle membrane contact site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.016
GSE199255,GSE199356_6_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.8902
BRD-K06250424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60668
BRD-K64268886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21409
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.428
BRD-K45058172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43092
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organelle envelope lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.65
PMC9999213-mmc3.xlsx-DEGs_CSc-DEA_NB_MSC_EC_CSc_vs_NB_CSc_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.791
Aortic adventitial fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.803
Calcineurin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.764
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.626
Mitochondrial respirasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.601
NOMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19868
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.28
BRD-K92399035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55798
GSE58724_1_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K52881132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09068
CRCGN016_MCF10A.WT.HP_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11627
PSMD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.45586
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE160246_0_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
10737_ZWILCH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.566934
mitochondrial outer membrane	GO Cellular Component Annotations 2023	1.0	null
BRD-K55142307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01826
BRD-K40088786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13493
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8279
GSE216538_1_v_3_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186508
RAB3GAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22434
CPVL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00472687
Proteasome core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.131
BRD-K15444511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11669
BRD-K59078001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0434
MEL-JUSO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.947
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1461
GSE87404,GSE87812_2_v_3_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mitochondrial outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.782
BRD-K97395479	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2272
MCF7_KW-2449_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0106786
GSE175787_5_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K94037108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04008
Peroxisomal importomer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.266
BRD-K03116744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08919
GSE249544,GSE249637_9_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00922768
BRD-K30065842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32613
GSE249544,GSE249637_6_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Charcot-Marie-Tooth disease type 4A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_PD98059_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166893
TMEM33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4268
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8487
LHX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27647
HOXA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03354
BRD-K25200031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01026
BRD-K48689133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08399
BRD-K83898323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72436
NOLC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00652745
WNT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00584447
BRD-K03344897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04449
mitochondrial membrane	GO Cellular Component Annotations 2025	1.0	null
MPZL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31874
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-AA_up_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2041
CRCGN015_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11192
GSE149903_0_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of organelle organization	GO Biological Process Annotations 2025	1.0	null
1148_CACTIN_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.522758
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.519
BRD-K45172622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66604
BRD-K86938753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81613
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14762
GSE146074_10_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K24965236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00461
BRD-K35058762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6657
BRD-A59683007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13257
BRD-K02637850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26018
proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.977
CRCGN015_HEPG2_48H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22696
GSE136894_2_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTF3C2-35216376-H9-HUMAN-BONEMARROW-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
1331_CCNJ_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.608972
CRCGN016_MCF10A.TP53.M_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05062
Mitochondrial crista junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.377
PMC9574515-mmc1.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K28467941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00149
BRD-K32343246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12236
HIPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29957
Endoplasmic reticulum subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
MCF7_Flavopiridol HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00874779
BRD-K95460104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15235
GSE195743_3_v_2_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A79248021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0682
BRD-K23905877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04158
GSE210885_2_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cybrid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.184
BRD-K41102088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24043
Perinuclear endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.524
protein localization to organelle	GO Biological Process Annotations 2023	1.0	null
BRD-K96733881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26846
Cortical endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.805
GSE113734_3_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K61909412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10033
TM9SF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00430067
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H2AC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00189
BRD-K82910696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72502
BRD-K13275816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28603
BRD-K19474742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43113
GSE199606_1_v_0_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A05422420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47498
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.634736
PMC9714459-DataSheet3.xlsx-Supplement_3A-1037_elements_included_exclusively_in_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193993_1_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AK8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00718126
A549_Danusertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112191
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	6.23782
GSE223540_2_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166944_3_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LUBAC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.271
K562_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140663
GSE48812_11_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_ABT-737_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013551
CRCGN017_MCF10A.WT.HP_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40625
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
A549_Streptozotocin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138142
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Muscular atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
decreased susceptibility to Riboviria infection induced morbidity/mortality	MGI Mouse Phenotype Associations 2023	1.0	null
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A05635986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23105
GSE114258_3_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Striated muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.559
CRCGN013_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.335
GSE157904_3_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LUC7L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96504
Combined oxidative phosphorylation deficiency 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.692
GSE210580_0_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K24167233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14365
4940_MED18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.716006
MCF7_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203813
BRD-K04371719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26069
BRD-K34710061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27274
GSE153757,GSE153758_1_v_3_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
endoplasmic reticulum membrane	GO Cellular Component Annotations 2023	1.0	null
Spadix	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.688
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Ki8751_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191609
protein localization to organelle	GO Biological Process Annotations 2025	1.0	null
8653_TAF12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.533799
PMC6999830__F1	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K01754917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83961
PMC9574515-mmc2.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K51697315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32527
GSE208254_4_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATP6V1E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18323
Mitochondrial outer membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.898
TFAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24398
BRD-K63394284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78818
FGFBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14567
GSE158834_10_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pore complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.71
A549_Alisertib_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124092
BRD-K17384993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19649
GSE88819_11_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
3050_FDPS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.517156
BRD-K82509605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68982
MS4A13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00473278
3054_FECH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.514967
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K52735829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0737
CSRNP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27889
BRD-K20714346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12727
PMF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02647
BRD-K90231936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2461
RGS18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00681015
GSE196117_6_v_11_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Apoptosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.956
Mitochondrial processing peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.433
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NID1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00523494
BRD-A68913459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70549
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6787
BRD-K66572611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12614
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Phosphatidylinositol 3-kinase complex, class III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.249
BRD-K21356734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2551
A549_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124631
BRD-K55518911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59566
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19315
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
GSE240645_3_v_2_u90926_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K13646706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2455
GSE128634,GSE128636_1_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K19829092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88084
BRD-A26952628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0204
MCF7_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171497
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
preweaning lethality, incomplete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
CRCGN013_HEPG2_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13953
BRD-K27028848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09591
GSE80098,GSE80366_0_v_5_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Respiratory chain complex III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.647
BRD-K85418917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09595
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.558685
PMC4292165__F2	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K88504000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2141
K562_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160652
UBFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28047
GSE196117_1_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE164757,GSE164759_1_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166315_1_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00695
GSE199606_3_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.18
EIF3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17825
BRD-K74300740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54432
GSE210476_2_v_7_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE128634,GSE128636_2_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEx Heart 20-29 vs 30-39	GTEx Tissue-Specific Aging Signatures	-1.0	-3.04423
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
CRCGN008_HEPG2_24H:A06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54105
BRD-K87193132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13448
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193993_5_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Uterine cervix	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.979
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.8934
GSE60691_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Vacuolar lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.967
GSE235945_1_v_0_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.752572
BRD-K00973124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5522
Peroxisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.857
Organelle outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.776
positive regulation of mitochondrion organization	GO Biological Process Annotations 2023	1.0	null
A549_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132739
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K86155400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30299
GNE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27523
Integral component of mitochondrial outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.008
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-A01528713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21836
MCF7_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131517
GSE141726,GSE141733_1_v_0_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K69751974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43113
BRD-K67531128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14655
BRD-A77181042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09177
Bcl-2 family protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.8
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07576
Peroxisomal matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.155
BRD-K35717699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09007
BRD-K36314834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10421
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.726
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.361
BRD-K70652938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1698
MDST8_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.06402
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_5_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K40732885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09998
GSE48812_0_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K80897487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30396
KLF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87268
anaphase-promoting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.336
BRD-K14122415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11067
Autosomal dominant cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.703
CRCGN017_MCF10A.WT.HP_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0774
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.463
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.417
Respiratory chain complex II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.167
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6612
CDAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39501
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organelle inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.236
BRD-K53770426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30664
GSE128634,GSE128636_2_v_3_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50884475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68735
regulation of mitochondrial fission	GO Biological Process Annotations 2023	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.098
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2777
GSE101112_6_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A59391763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12758
BRD-K17372597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27024
GSE144453,GSE144454_1_v_0_tfdp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE220914_2_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Peeling skin syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.521
BRD-A57353172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59089
Retromer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.111
K562_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153508
MCF7_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176394
BRD-K04143388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0627
BRD-K25081075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06483
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.763
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K60543885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1421
GSE136894_1_v_0_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE203308_14_v_5_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23701005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13077
Neck	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.363
Mitochondrion	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.622
A549_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165711
Phagophore assembly site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.833
BRD-K11566857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57099
GSE199255,GSE199356_6_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Succinate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.174
Wolfram syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.597
Hand	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.02
BRD-K21232462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27508
CRCGN016_MCF10A.WT.HP_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1804
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K67284043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.035
BRD-K89701103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61877
GSE255680_1_v_0_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mitochondrial DNA depletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
Stomach	GTEx Tissue Gene Expression Profiles 2023	1.0	1.53416
BRD-K68305833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80388
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.503
PPP6C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57741
GSE221356_1_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU1079_BILIARY_TRACT	CCLE Cell Line Proteomics	1.0	3.14175
GSE112760,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K47980183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34734
Vitamin K4_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0184446
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5817
MCF7_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117949
BRD-K82538319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.36806
K562_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174352
GSE237426_0_v_1_eif4a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K01148617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39279
BRD-K30992744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71091
1716_CNOT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.51666
GSE100316_5_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.363
CRCGN014_HEPG2_3H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8445
Congenital nervous system abnormality	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
BRD-K01894374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11479
RUNX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7091
GSE147943_0_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE129725_4_v_0_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.36
Inclusion body myopathy with Paget disease of bone and frontotemporal dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.381
Mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
ALDOA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48282
GSE212486,GSE212488_0_v_1_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.253
Hereditary spastic paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
GSE182680,GSE182683_0_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4627
6558_POLR3D_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20493
BRD-K21051792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12379
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K81925504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59982
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.376
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K74198088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45601
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K68347834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89215
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EmrE multidrug transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.06
GSE124410_2_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Laryngeal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.768
Mitochondrial outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE221101_1_v_0_hopx_human	RummaGEO Gene Perturbation Signatures	1.0	null
ubiquitin-like protein ligase activity	GO Molecular Function Annotations 2025	1.0	null
COS-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.397
BRD-K85311003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39662
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
regulation of mitochondrion organization	GO Biological Process Annotations 2023	1.0	null
BRD-K12226398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32227
MCF7_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141988
BRD-K53540914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32235
BRD-K61223323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00261
BRD-K12107412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07997
GSE183101_0_v_1_hvcn1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.406
GSE168587,GSE168752_3_v_1_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149927
A549_SRT3025 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01508
PMC12119775-13402_2024_1033_MOESM1_ESM.pdf-30-ENSG00000135100_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Oxoglutarate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.01
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.09071
TIM23 mitochondrial import inner membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.868
CRCGN011_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3158
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56163
BRD-K95798946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06166
CRCGN008_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8713
BRD-K72651085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38169
CRCGN015_HEPG2_48H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.00657
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCT-116 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.628
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.248
Neuroblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.672
Fhm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.653
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137771
A549_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152545
GSE164463_3_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ERGIC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0579
PMC9574515-mmc1.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K21416096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61024
GSE160817_5_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
protein polyubiquitination	GO Biological Process Annotations 2023	1.0	null
Mycolate outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.33
BRD-K75067815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43854
GSE178255_3_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K70361311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18185
Steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
BRD-K45612428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14583
MCF7_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115056
BRD-K60216304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7108
BRD-K76645599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94229
Nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.07
BRD-K60456515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49937
BRD-K00505499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22052
positive regulation of developmental process	GO Biological Process Annotations 2023	1.0	null
7393_RNF4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.557422
BRD-K84391462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40495
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.592
BRD-K28916436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15721
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162473
BRD-A95683194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83183
BRD-K31896531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14812
NCIH2122_LUNG	CCLE Cell Line Proteomics	1.0	4.07973
GSE210842_3_v_1_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_PSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K34957967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.059
GSE158834_0_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4888
GSE192513,GSE192515_2_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K74329400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03665
MCF7_SB431542_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138458
GSE217115_2_v_0_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K66145389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51369
BRD-K77554584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06701
MCF7_Alvespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0106875
GSE158834_12_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5538
RFC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18151
PMC12697907-ADVS-12-e07451-s002.xlsx-ST9A_overlap-NvM-Table_S9A_Pair-wise_Z-score_test_calculating_the_overlap_between_gene-cancer_MR_estimates_in_na鴳e_vs_memory_CD4_T_cells_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1839
BRD-K34258713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97058
Bone marrow	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.077
ZBTB32	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0052342
TOM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.017
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K36252987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45405
BRD-K44061011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09019
A549_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188072
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Coronary artery endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.791
BRD-K05253426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26991
ubiquitin protein ligase activity	GO Molecular Function Annotations 2023	1.0	null
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135514_8_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K68247783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34297
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0881
BRD-A05456882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73145
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.717
Retinal ganglion cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.274
H4 neuroglioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.762
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.713
MCF7_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234986
Uterus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K20470077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40155
PMC7961017-41467_2021_21928_MOESM4_ESM.xlsx-MAIT_CLUSTERS_FIGURE_3-NOT_ACTIVATED_MAIT_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Cardiac muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.257
BRD-K87593103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06858
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8297
BRD-K90594901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2288
BRD-K31851055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84097
Cytosolic proteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.953
BRD-K85456301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22229
AR-35650195-DSRCT-HUMAN-MESENCHYMAL-SARCOMA	ChEA Transcription Factor Targets 2022	1.0	null
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
proton-transporting two-sector ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.971
BRD-K75168124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08199
Thyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.363
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.506
mitochondrial membrane	GO Cellular Component Annotations 2023	1.0	null
SCAMP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00492467
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.579
EPHX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00536744
GSE246660_1_v_0_lmo3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.8867
PMC8047323-Table_1.xlsx-FC_LPS_T24_Vs_LPS_T0_P_0_05_FC-GeneSymbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
B4GALNT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00566586
Secondary lysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.502
Cytosolic region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.818
CRCGN016_MCF10A.TP53.M_24H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0714
BRD-K96449536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23129
GSE116299_6_v_5_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A39900448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15217
4950_MED27_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.1942
BRD-K84936524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91522
BRD-K55815187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49653
GSE160246_9_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.89796
BRD-K43449580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85658
Endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE205163,GSE205164_3_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143714
Digenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.503
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4756
MCF7_Decitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177673
K562_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015261
GSE172020_0_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.18979
MCF7_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132475
Intrinsic component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.626
BRD-K93817456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61618
GSE166317_3_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cardiac muscle fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.945
CRCGN015_MCF10A.TP53.M_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.81095
GSE120413,GSE120447_3_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K47821225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5137
GSE210655_3_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE163052,GSE163198_5_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE191174_0_v_1_ccdc92_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Rough endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.333
A549_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155383
GSE228894_0_v_2_rnmt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6075
BRD-K41946683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26415
KIF21B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00469894
CRCGN013_HEPG2_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37071
K562_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173022
PMC12005766-ADVS-12-2413120-s003.xlsx-VENN2-Table_S6_related_to_Figure_S6D_List_of_overlapping_DEGs_screened_in_VENN1_with_E3s_interacting_with_EZH2_or_MYC_from_the_UbiBrowser_v2_database_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112763,GSE112767_0_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178255_3_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K57045425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25981
BRD-K96491664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56964
GSE149123,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K64531863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04605
GSE123943_4_v_5_sox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
NF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21229
GSE86507,GSE86509_3_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K32124229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05749
Disease of metabolism	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.506
CRCGN015_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27895
859_BMS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.547173
BRD-K45044525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43739
MCF7_KW-2449_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170509
RTP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00582157
GSE107505_1_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0793
GSE130383_1_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
FES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86586
BRD-K24369860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16914
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.551
A549_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0250574
GSE225218_0_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8493
CRCGN016_MCF10A.TP53.M_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5739
LAMB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01144
Integral component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.731
protein localization to mitochondrion	GO Biological Process Annotations 2025	1.0	null
RQC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.648
Mitochondrial respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.008
BRD-K59392325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34791
GSE195568_1_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0238499
GSE185519_3_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TMEM68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11403
RDH14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31664
GSE158834_2_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE249544,GSE249637_6_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151719
AIM2 inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.667
MIM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.767
BRD-K04399953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0554
prenatal lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.5402
SERPINE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29892
BRD-K24333636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63657
Autophagosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.083
SH-SY5Y cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.58
POLE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00307689
BRD-K02093145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05487
ABHD13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28046
mitochondria-associated endoplasmic reticulum membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.258
MCF7_AZ 960_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0108617
A549_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150931
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.385
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124832
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7477
BRD-K53088255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89029
BRD-K41063113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26097
BRD-K82609503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32478
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
protein ubiquitination	GO Biological Process Annotations 2025	1.0	null
Zfp809	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	49.6787
A549_Aminoglutethimide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156634
BRD-K23664196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21804
BRD-K10820981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49898
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cranial nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.803
BRD-K40057256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.35988
CRCGN008_HEPG2_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0055
PMC11399095-44161_2024_532_MOESM14_ESM.xlsx-Sheet1-Supplementary_Table_13_DEG_in_the_AA_borderzone_in_AF_vs_SR_patients_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Mitochondrial crista	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.771
GSE201270,GSE201272_0_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE249544,GSE249637_6_v_2_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A11154023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67923
BRD-K69854611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54498
PMC10149505-41392_2023_1393_MOESM2_ESM.xlsx-CPCMR-Hugo_Symbol_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K71007902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65275
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K24004917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61613
GSE132408_1_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TUBB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17893
BRD-K81916372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42832
FARSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33805
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
CRCGN012_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0313
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.805
BRD-K34232791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56597
7561_RRP12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.551347
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.2067
BRD-K98537764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20826
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.486
AQR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70013
BRD-K83553001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.329
GSE169356_0_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.415
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.007
Endoplasmic reticulum membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
TPCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1045
GSE112860_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K67409155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18887
Cell outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.203
GSE158834_12_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE232558_0_v_2_fbxl12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K04468899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29681
Twig	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.424
t66-lung_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.43668
Mitochondrial prohibitin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.149
positive regulation of mitochondrial fission	GO Biological Process Annotations 2023	1.0	null
VANGL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00512244
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPP4R3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00610141
KIF2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09254
protein autoubiquitination	GO Biological Process Annotations 2023	1.0	null
Dominant optic atrophy plus syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
496100337_HIP_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.42169
PHF20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51327
BRD-A85231803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11954
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE144231_6_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KRT12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00619616
BRD-K08141534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01089
GSE114992,GSE114993_7_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146074_6_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K31852848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59793
BRD-K36241360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06985
BRD-K33179234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51256
8332_SPC25_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.549246
GSE209973_1_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04163641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37931
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K88758204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06548
SMCO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72782
cAMP-dependent protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.561
GSE148692,GSE148695_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K44520987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87376
GSE148510_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K98856654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38753
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.517
Mitochondrial complex IV deficiency nuclear type 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
Endoplasmic reticulum chaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.422
GSE193751_1_v_3_oridonin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K15322427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1227
PMC9589484-fcell-10-1022723.nxml--NETs_NOT_affecting_nuclear_size_upon_overexpression_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.4007
K562_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176959
GSE158834_2_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.803
BRD-K78074905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5298
GSE158834_0_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE190534,GSE190536_0_v_2_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43548
MCF7_Regorafenib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128167
REX1BD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58521
Autolysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.572
Proteasome regulatory particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.909
BRD-A46317335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10986
BRD-K70886325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06267
Endoplasmic reticulum lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.231
PNMA6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16897
GSE181461_1_v_4_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE212486,GSE212488_2_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K56272400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25617
CMK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	9.69521
BRD-K68379391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26175
CRCGN011_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02665
BRD-A59009217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57385
GSE199606_1_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K35404627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72977
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.584
GSE186440,GSE186443_2_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K12132610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.371
BRD-K62942008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02196
CRCGN016_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11273
ACSM2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3885
GSE248045,GSE248046_6_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8295
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Machado-Joseph disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.812
CHTF18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39409
BRD-K25045770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02381
GSE87299_2_v_3_nr1d1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224004,GSE224005_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Tazarotene_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0105673
MCF7_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0100953
Forestomach	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.28
Tofacitinib (citrate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0231494
BRD-K47261271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09574
1844_CPSF6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.666072
CRCGN015_MCF10A_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.3426
BRD-K20451745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21606
BRD-K40894545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14901
BRD-K87269010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22882
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_2_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.902
HeLa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.063
GSE131161_3_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K38240683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.425
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
859_BMS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.655181
BRD-K28596340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11367
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
496100547_HIP_no dementia_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07208
Mitochondrial derivative	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.726
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE112860_3_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76616863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37873
GSE148262,GSE150691_1_v_2_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K14250524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90135
GSE128634,GSE128636_2_v_0_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K31030467	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18907
Peeling skin syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.428
BRD-K66675422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31519
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4256
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Ensembl_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Frontotemporal dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.354
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHRNA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00514214
BRD-K74506898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60284
GSE148066,GSE157787_9_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K66408914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21207
TIM22 mitochondrial import inner membrane insertion complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.987
GSE158834_10_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHMP2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00777414
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22764
GSE93309_2_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149903_0_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.225
BRD-K67979704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02187
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	1.0	null
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
BRD-K59100858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30507
BRD-K39692099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05372
GSE249544,GSE249637_6_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Endopeptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.277
BRD-K27458941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11201
Alkyl hydroperoxide reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.57
GSE117212,GSE117214_0_v_1_zbtb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199606_1_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
Mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.257
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.095
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.752
GRHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01585
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120232
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.736
BRD-K51927648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40505
BRD-K20987582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18699
BRD-K24496049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13444
CRCGN010_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31655
BRD-K78873216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20483
Bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
H3C12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01644
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_MC1568_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169863
496100592_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.23973
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE155305_2_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122163
RBBP6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00882382
BRD-K39435284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27543
BRD-K70594121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25057
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6306
protein polyubiquitination	GO Biological Process Annotations 2025	1.0	null
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K44713204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25582
GSE178255_3_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE230656_0_v_1_gsdmd_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
protein localization to mitochondrion	GO Biological Process Annotations 2023	1.0	null
CRCGN008_HEPG2_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59325
GSE182680,GSE182683_5_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K90360779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34282
Mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Mitochondrial metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.4
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11335
BRD-A99687212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5186
BRD-K53774433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65654
GSE158834_12_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
increased circulating interferon-beta level	MGI Mouse Phenotype Associations 2023	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.417
Reticulum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.387
CRCGN016_MCF10A.TP53.M_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5471
GSE173578_1_v_0_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217132_0_v_1_pfkfb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0113546
CRCGN009_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.917
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3014
BRD-K59188100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60221
BRD-K11715561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09582
K562_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212558
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE100316_5_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K46001734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03607
K562_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148603
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
6024_PABPC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.626638
Behr syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.323
BRD-K19958830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19921
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K66717300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02286
Neuromuscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.569
BRD-A97759891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62493
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178340_1_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pontocerebellar hypoplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.162
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.047
BRD-K29392777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23937
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.9957
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE224969,GSE224971_0_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pars compacta	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.311
t30-blood-rna_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.91726
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7241
GSE235701,GSE261434_0_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211126_1_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149721
Inherited metabolic disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.506
TFAP4::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7029
MCF7_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.011815
BRD-K43603649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68094
Atg1/ULK1 kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.595
BRD-K65823297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.45605
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118765_1_v_5_rreb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K64055724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18071
GSE154081_3_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Respirasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.965
Mitochondrial cloud	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.129
BRD-K11942486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5129
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lysosomal lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.934
BRD-K19652835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47331
MCF7_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132756
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1461
BRD-K64732418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1335
GSE188870,GSE188871_1_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50716325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16938
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171179,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
SRRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26644
BRD-K83586473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44024
GSE154069_2_v_4_satb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Microbody membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.549
lufenuron	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25875
ZNF382	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.004
MCF7_Pelitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182494
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.215
GSE254517_2_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPLP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01179
GSE149124,GSE149128_2_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LRRC10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11259
POU2AF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09569
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Enzastaurin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194366
GSE214248_0_v_1_cxcl8_human	RummaGEO Gene Perturbation Signatures	1.0	null
KLHL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0377
GSE226249_5_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.377
BRD-K96023136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13709
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3926
BRD-K24220535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93353
Phagophore assembly site membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.166
MCF7_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155747
CRCGN015_HEPG2_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70276
Mitochondrial intermembrane space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.721
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11493601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05552
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120413,GSE120447_0_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70533557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3262
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ATG13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04474
STK38L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519448
MCF7_G007-LK_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144976
CRCGN015_MCF10A.TP53.M_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19985
1475_CENPA_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.530665
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.395
BRD-K08715918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00362
CNTN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0070884
CREBBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00600916
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_SRT2104_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147515
BRD-K06480376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35149
BRD-K95656102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07262
Outer mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.229
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
STING complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.457
NADH dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.924
ER ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.714
HOXD10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9004
BRD-K17136501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03131
ZNF367	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00733768
BRD-K90316899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87282
7251_RFFL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.505776
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8040704-jcav12p2673s2.xlsx-Down-regulated_genes_in_EBF1-Unnamed_5_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE144443_0_v_6_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K92700781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66455
BRD-K44292107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67891
4604_LLGL2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.555569
BRD-K87853964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44208
MGAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09101
BRD-K87580376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01919
BRD-K08607520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23792
MCF7_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0122795
Nebenkern	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.862
BRD-K34282646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01684
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K62659610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16038
BRD-K16207265	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30182
IL1RL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602624
GSE114992,GSE114993_4_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203104
BRD-K89121101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10285
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.239
CDK11B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00451031
GSE158834_12_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89051
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2263
GSE213996_1_v_0_fhl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE189599,GSE196004_0_v_1_bend2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Tofacitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186077
ubiquitin protein ligase activity	GO Molecular Function Annotations 2025	1.0	null
CRCGN015_MCF10A.TP53.M_24H:D14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3949
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.468
CRCGN015_MCF10A.TP53.M_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8893
GSE207135_1_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	1.0	null
UBC13-UEV1A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.515
BRD-K26976202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08166
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HNRNPM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41072
DLG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00601755
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE220668_0_v_1_ncapg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K03067757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18219
SIRT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555994
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.28961
Sec61 translocon complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.784
BRD-K85216683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30288
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.556
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
Nuclear outer membrane-endoplasmic reticulum membrane network	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE146156_1_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K33760911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0926
BRD-K73531877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0235
A549_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144021
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02838
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.3
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K31521981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65947
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.573
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.6425
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	158.727
Embryonic fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.736
ERCC6L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07317
GSE158834_2_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K63614330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59586
GSE217552_3_v_5_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7423359-abb8771_Table_S4.xlsx-Sheet1-Genes_detected_at_least_twice_in_h4E_BP1-hyperTRIBE_711_genes_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
496100432_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06248
GSE146687_2_v_5_eribulin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K81522184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24813
BRD-K61924304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39198
CRCGN008_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3969
BRD-K98578493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90523
PPIE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31404
GSE217115_2_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.92745
CRCGN012_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0568
Dihydrolipoyl dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.224
BRD-K78612514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10074
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Up_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174181
BRD-K51743001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66302
rifamycin-sv	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1711
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.377
GSE242199_9_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.383
GSE152666,GSE152668_2_v_1_carm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Colon - Transverse	GTEx Tissue Gene Expression Profiles 2023	1.0	2.8606
GSE196117_6_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
4954_MED31_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.18647
BRD-K30548577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75059
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
endoplasmic reticulum membrane	GO Cellular Component Annotations 2025	1.0	null
GSE101546_2_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11385366-Table2.xlsx-DBP-Overlapped_Gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K82681356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21624
BRD-K94082609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31982
GSE140651,GSE140653_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K82662168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95287
BRD-K59194147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13881
GSE201239_3_v_4_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199606_3_v_0_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE214335_1_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
OCI-AML2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.576
MCF7_Disulfiram_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143089
NCIH716_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	5.0648
ACO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38256
BRD-K43126701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36812
2633_EN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.588532
BRD-K12325488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0491
FOXR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47209
GSE222574_0_v_2_lmna_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SCF-Mdm30 ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.111
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.298
BRD-K50400833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14612
BRD-K48255349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66269
BRD-K80736363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19945
A549_Bisindolylmaleimide IX_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140751
BRD-K66659401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.35734
Smith-Magenis syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
PLEKHM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25083
BRD-K34360192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17263
Antral mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.679
K562_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018435
MIB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.407
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
RBAK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22126
KU1919_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	3.39241
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.89
BRD-K94697940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8682
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:M18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38537
Inclusion body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.583
BRD-K19225848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7813
GSE158834_10_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.6101
GNAI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37121
PMC5580928__F1	PFOCR Pathway Figure Associations 2023	1.0	null
GSE160373_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166142
BRD-K76618080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1125
GSE158834_7_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144018
BRD-K92349794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55676
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.372
TNP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00515114
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Wolfram syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.511
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.479
MCF7_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175669
K562_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162809
Dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.491
GSE120413,GSE120447_4_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mitophagy - animal	KEGG Pathways 2026	1.0	null
Outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Cervical cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.047
BRD-K76067434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15529
BRD-K35963610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40996
Movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.512
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KIR2DS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00643312
A549_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162284
GSE81796_0_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100364_TCx_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.31634
K562_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232716
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K64537490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25343
TFF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00658225
BRD-K45042519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3328
GSE124920_1_v_2_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.406
Mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.578
Tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.217
BRD-K86855109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40845
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	110.461
GSE148066,GSE157787_0_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
rab9	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.216
BORCS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24339
Mitochondrial chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.079
BCKDK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00441156
Peroxisomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
NMRK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31255
GSE199606_3_v_0_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K07939054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2073
MAGOHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25201
Thymus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	3.383
BRD-K93503664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14553
BRD-K95551067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23638
CRCGN008_HEPG2_24H:L15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2284
BRD-K34851865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09905
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Integral component of organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.545
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-Aza_atRA_DE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K35909757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23137
GSE114232_8_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8361
Mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE114992,GSE114993_9_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIPA1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00553313
BRD-K99116119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28793
GSE100316_7_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146787
PMC9378714-41467_2022_31999_MOESM10_ESM.xlsx-Supplementary_Data_7-Supplementary_Data_7_Collation_of_genes_possible_regulated_or_co-expressed_with_ELF5_ELF5	Rummagene Transcription Factor Associations 2026	1.0	null
LONRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26755
Diabetes mellitus	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.506
BRD-K04251837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84588
BRD-K68663367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59338
GSE158834_2_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K99413603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17008
CZIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26807
BRD-K76125116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1172
PMC7555132__F3	PFOCR Pathway Figure Associations 2023	1.0	null
Endoplasmic reticulum tubular network	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.791
SIGLEC12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00670986
BRD-K51515697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56798
LRSAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0563
GSE133213_6_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPL15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2705
RECQL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31159
Phagophore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.764
GSE171269_1_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ps96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.532
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K57894545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41666
PMC8851354-Table_6.xlsx-Ruxolitinib_reg_STAT3-bound-Supplementary_Table_6_Genes_regulated_by_ruxolitinib_that_are_STAT3_targets_in_at_least_two_cell_lines_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201239_6_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ROBO3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.005344
BRD-K64823749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07878
GSE233679_6_v_11_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K52833964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29177
regulation of mitochondrion organization	GO Biological Process Annotations 2025	1.0	null
ZHX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00707953
BRD-K02637547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21556
BRD-K39153737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88203
PMC12005766-ADVS-12-2413120-s003.xlsx-VENN1-Table_S6_related_to_Figure_S6D_List_of_overlapping_DEGs_with_the_E3_or_DUB_gene_set_from_the_iUUCD_2_0_database_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K68953461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96986
Reticulocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.371
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9138
A549_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153993
K562_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161079
BRD-K63858518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06061
BRD-K64221857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15462
BRD-K25426017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91696
BRD-K44975377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42177
GSE125782_0_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE188870,GSE188871_1_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218879_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Charcot-Marie-Tooth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.724
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164463_4_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K40145790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05244
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K48717228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32077
GSE169356_2_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29135
4158_IP6K1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.693242
A549_Selisistat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150959
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.805
BRD-K05777604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61057
BRD-K12524104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02975
BRD-K51654114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24883
mitochondrial outer membrane	GO Cellular Component Annotations 2025	1.0	null
MCF7_Celecoxib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228324
PMC11568168-41598_2024_79607_MOESM3_ESM.xls-11-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of anatomical structure morphogenesis	GO Biological Process Annotations 2025	1.0	null
BRD-K62577212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83683
pb1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.317
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.475
BRD-K02269304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76973
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
EML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28329
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
Ubiquitin activating enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.627
GSE148200_1_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE88819_5_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mitochondrial respiratory chain complex III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.819
GSE231648_1_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146175
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_LF_species_not_found_in_common_genes_of_R_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K63920153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16066
BRD-K43680691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.199
BRD-K37282009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86154
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.144
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.373
STX1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00683788
CIITA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85308
A549_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231293
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
BRD-K57343972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28802
GSE185922_1_v_2_riok2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Endoplasmic reticulum quality control compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.573
CRCGN016_MCF10A.WT.HP_24H:E22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00765
BRD-K75497233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45404
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K91843292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00165
A549_Ofloxacin_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120864
BRD-K54903703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66521
KRT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13438
MCF7_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143152
BRD-K71881549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2558
BRD-K63761383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66721
CRCGN008_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16085
Carbohydrate metabolic disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.506
MAP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00463415
BRD-K54066059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69534
Protein serine/threonine phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.646
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K38766433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24609
GSE127790_10_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A498_KIDNEY	CCLE Cell Line Proteomics	1.0	2.01226
GSE217132_0_v_1_pfkfb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K94521090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54383
GSE261563_6_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Organelle envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.503
Endopeptidase Clp complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.539
CYB5D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00944275
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.477
GSE131425_2_v_0_arg2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0245183
G cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.699
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-2cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
MTAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00453773
PMC6187090-mmc1.xlsx-TP53_positive-Symbol_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
MEF cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.427
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.139
MCF7_MC1568_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01413
GSE65617_0_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_2_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143348
496100575_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.05648
RNASE6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00567888
Protein kinase CK2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.891
Autosomal dominant nonsyndromic deafness 67	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
CRCGN014_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50337
Autophagosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.087
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_CUDC-101_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187164
CRCGN015_MCF10A.WT.HP_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.80866
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.335
Peeling skin syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.3
BRD-K93884191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52338
hTERT-RPE1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.83
GSE240809_0_v_1_hnrnpa2b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_8_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Invertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.241
A549_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144476
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K45091989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37563
GSE220097_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Trametinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110902
GSE185944_5_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K37271110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49967
BRD-K30025024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25456
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.581
Intrinsic component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.607
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1388
PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-S_72h_1-Unnamed_0_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.513716
GSE114992,GSE114993_1_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K60886324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07534
GSE183251_1_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194363
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.701
PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
NUDT17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57698
PMC7468443-Data_Sheet_2.xlsx-DEG_6h_LPS-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Atg12-Atg5-Atg16 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.642
BRD-K34335352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16946
PMC11629026-VMS3-11-e70074-s003.xlsx-SRY-Gene_name_SRY	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26765
Arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
CHRNB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0057159
RASSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15678
BRD-K31233830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96582
Peroxisomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.55
CRCGN017_MCF10A.TP53.M_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07295
GSE166944_0_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ISCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14373
BRD-K38706080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58041
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE154069_2_v_1_satb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE189609_1_v_0_hax1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Derlin-1 retrotranslocation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.731
BRD-K72770355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28924
BRD-K11823863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30348
PMC10209342-mmc9.xlsx-UBE2D3_interactors-UBE2D3_interactors_used_for_Venn_Diagrams_from_MINT_STRING_UniProt_IntAct_BioGRID_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5404927-elife-24463-supp1.xlsx-1b_ERM_proteome-Gene_names_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22610244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79958
BRD-K93496326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0456
BRD-K66733186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16055
CRCGN013_HEPG2_24H:K04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13075
BRD-K10241968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64027
BRD-K92444813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41896
PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Upregulated_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
Toxic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.345
CRCGN014_HEPG2_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5965
BRD-K13119652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42966
GSE217156_1_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K02315086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9715
GSE204784,GSE204787_1_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Respiratory chain complex IV	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.336
GSE112365_0_v_1_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE124410_3_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ADNP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20705
ubiquitin-protein transferase activity	GO Molecular Function Annotations 2023	1.0	null
RNF168	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59675
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K97624853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32389
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.68152
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16995
BRD-K63476888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1178
Integral component of peroxisomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.827
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	112.037
CRCGN008_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0697
mitochondrion-derived vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.515
GSE94814_2_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Giant cell tumor cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.564
BRD-K61439332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56303
BRD-K19662956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37744
BRD-K10925833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14392
MCF7_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267707
Zfp961	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.8216
BRD-K15474464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81203
Organelle subcompartment	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE158834_12_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160817_5_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K69901388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07679
Organellar small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.803
MCF7_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228064
Polygenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.446
t30-blood-rna_male_8w	MoTrPAC Rat Endurance Exercise Training	1.0	1.35751
Organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Cyclin B1-CDK1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.831
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K15343767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79664
GTPase binding	GO Molecular Function Annotations 2023	1.0	null
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.429
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178255_3_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE87404,GSE87812_2_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K10423475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48036
CHRNA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29977
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7862
BRD-K06790927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32398
BRD-K42508877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07871
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.533
MCF7_MK-0752_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144961
BRD-K79732056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2091
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.104
CRCGN012_HEPG2_24H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06833
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.148
MCF7_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110749
EBF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10042
BRD-K80240487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51042
BRD-K51087734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00258
SNAPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64716
BRD-K43388152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18099
Primary effusion lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.651
BRD-K12240312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18355
Alpers-Huttenlocher syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
CRCGN016_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30025
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.363
HEY cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.561
BRD-K14645917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37016
BRD-K62147342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29465
3706_HESX1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.747299
Intrinsic component of mitochondrial outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.806
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1357
CRCGN012_HEPG2_24H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14165
BRD-K08723967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11964
GSE133213_6_v_5_znrf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K94657740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69796
GSE178255_2_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57724
BRD-K08355771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30641
ubiquitin-like protein ligase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K14081852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28049
BRD-K15654812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68207
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.833
GSE221327_5_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELOVL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86427
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K83673542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03353
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0731
regulation of mitochondrial fission	GO Biological Process Annotations 2025	1.0	null
MCF7_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140253
BRD-K50240676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15673
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.199
METTL23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-2cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_10_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE98705_1_v_0_mdm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LYSP100-associated nuclear domain	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.577
GSE223008_6_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0948
MCF7_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131139
AMIGO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00576597
GSE211989_0_v_1_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_6_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178340_1_v_9_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0926
K562_Tucidinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014585
MCF7_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149605
GSE114992,GSE114993_7_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149421
TRIM61	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0074766
MCF7_BRD4770_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015394
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K29992178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2646
MCF7_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016945
GSE199606_1_v_0_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K04095185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26608
CRCGN014_HEPG2_3H:J14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14409
PMC8047323-Table_3.xlsx-Venn_581_LPS_T24_vs_LPS_T0-GeneSymbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
A549_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191251
BRD-K60861976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37344
BRD-K94205659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23029
BRD-K81293413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5958
BRD-K67403750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31984
positive regulation of developmental process	GO Biological Process Annotations 2025	1.0	null
SH2D2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554732
MCF7_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206332
MYADM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11834
BRD-K06157545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57142
Aggresome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.005
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K12782513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14914
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-2cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75772626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22048
BRD-K86008496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15095
GSE178255_2_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Microbody	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.859
A549_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.012112
BRD-K71486446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26847
Organelle outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
GSE124410_2_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112763,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1038
BRD-K81104218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72226
Huntington's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.668
SPATA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00787411
BRD-K66748326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64558
GSE154767_1_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142684_4_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain - Caudate (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.07389
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0135
Cardiomyocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.112
BRD-K19755525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58287
BRD-K59970200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53057
Catalase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.296
A549_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132452
BRD-K98968761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36042
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
UFD1-NPL4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.583
BRD-K42809349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59831
CRCGN015_MCF10A.TP53.M_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09961
BRD-K57323824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33994
PMC7825356-8844261.f3.docx-47-KLF12_KLF12	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K48864953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04832
Neurofibrillary tangle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.041
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC3526425-1471-2164-13-572-S3.xlsx-STAT6-STAT6_STAT6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE232786_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
A549_UNC0631_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121949
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_UP_AA_UP-AA_UP_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
protein ubiquitination	GO Biological Process Annotations 2023	1.0	null
t60-adrenal_male_1w	MoTrPAC Rat Endurance Exercise Training	1.0	1.63421
GSE58724_3_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8472
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K56428170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09047
BRD-K11143221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72427
4220_ITFG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.749026
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PK-15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.713
BAK complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.771
IL10RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00670001
BRD-A71590475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03135
GSE94814_1_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K75220555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17061
BRD-K28446462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1164
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K18435317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72708
Membrane fusion priming complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.836
SIRT4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00432747
Organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.46
GSE88819_6_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K62068620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10048
regulation of anatomical structure morphogenesis	GO Biological Process Annotations 2023	1.0	null
GSE148200_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
USP9X	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00775413
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.6086
BRD-K55538850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01311
ubiquitin-protein transferase activity	GO Molecular Function Annotations 2025	1.0	null
nucleus-vacuole junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.659
GSE158834_0_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
496100478_HIP_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.55187
HMX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44378
AXIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27996
IRAK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12919
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.634
BRD-K61182411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13163