association dataset threshold value standardized value BRD-K37763427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03003 H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null olfactorybulb BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.00485 Inferior frontal gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.611 RT4 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.50355 CESS GDSC Cell Line Gene Expression Profiles 1.0 1.5869 GSE152666,GSE152668_2_v_1_carm1_mouse RummaGEO Gene Perturbation Signatures 1.0 null TBL1XR1 ENCODE Transcription Factor Targets 1.0 null TAL1-26923725-CHIP-SEQ-HPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null malaria DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.276514 GSE205316,GSE205317_0_v_1_nrip1_mouse RummaGEO Gene Perturbation Signatures 1.0 null nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null ATF3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GBP5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00656476 isthmic portion of paranigral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1054 KRT1 Pathway Commons Protein-Protein Interactions 1.0 null MCF7_RG108_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0186156 GF1-26923725-CHIP-SEQ-HPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null envelope COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null purine ribonucleoside triphosphate binding GO Molecular Function Annotations 2015 1.0 null GTEX-XV7Q-0226-SM-4BRVL GTEx Tissue Sample Gene Expression Profiles 1.0 1.33272 Lewy body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.168 TUFM Pathway Commons Protein-Protein Interactions 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:B11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.79094 Central amygdalar nucleus, capsular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16993 arcuate nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.904976 EFM-19 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.22215 myeloid progenitor cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.070873 GSE158197_5_v_4_egfr_mouse RummaGEO Gene Perturbation Signatures 1.0 null MCF7_AR-42_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.012212 GTEX-O5YT-1326-SM-3MJGR GTEx Tissue Sample Gene Expression Profiles 1.0 1.42059 Brain Lower Grade Glioma_LGG_TCGA-P5-A733-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATXN2L Pathway Commons Protein-Protein Interactions 1.0 null lateral part of MM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.81591 H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCL Pathway Commons Protein-Protein Interactions 1.0 null HAP-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.799 3-methylcrotonyl-CoA carboxylase 1 deficiency ClinVar Gene-Phenotype Associations 2025 1.0 null ovary ProteomicsDB Cell Type and Tissue Protein Expression Profiles 1.0 1.00708 Lung adenocarcinoma_LUAD_TCGA-97-8171-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5455-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ETS1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.933501 GSE247230_0_v_1_anp32b_human RummaGEO Gene Perturbation Signatures 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null eye and adnexa disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040762 alpha-amino acid catabolic process GO Biological Process Annotations 2023 1.0 null NFYA_01_288 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.00343 Defective TCN2 causes hereditary megaloblastic anemia Reactome Pathways 2014 1.0 null Inferior temporal gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.149 Distal arthrogryposis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.109 cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.885946 CRCGN013_HEPG2_24H:K06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.52765 SAP30 ENCODE Transcription Factor Targets 1.0 null SK-ES-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.98966 cellular amino acid catabolic process GO Biological Process Annotations 2015 1.0 null olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.597 GSE155567_1_v_0_cd33_human RummaGEO Gene Perturbation Signatures -1.0 null GSE214505_0_v_1_akr1b1_human RummaGEO Gene Perturbation Signatures 1.0 null MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WYJK-0005-SM-3NMA1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.972799 organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.625465 H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_10718_KO_Hck_SRP340501 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.79094 GSE242083,GSE242098_2_v_5_med1_human RummaGEO Gene Perturbation Signatures 1.0 null SBNO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.264 GTEX-PVOW-0006-SM-3NMB8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21926 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K00853706 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01655 fat_a.V1 HPA Tissue Sample Gene Expression Profiles 1.0 0.901099 emboliform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.11893 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 mediodorsal nucleus of thalamus_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.93845 H3K9me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-73-7499-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IRF1-21803131-MONOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null prepositus hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25087 branched-chain amino acid catabolic process GO Biological Process Annotations 2023 1.0 null HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.975065 H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4443 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 medial septal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.919908 TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GB-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A430-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REST_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE206729_3_v_1_trps1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-R3RS-0005-SM-3GAEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1591 mammillary area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79467 cytosol GO Cellular Component Annotations 2015 1.0 null BRD-K38081867 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04633 CRCGN009_HEPG2_24H:H02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.25826 Weight Loss CTD Gene-Disease Associations 1.0 1.56875 K562_G007-LK_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0233798 NR1I2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.2266 Nr2e3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.0 GSE141328_3_v_2_rock2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BL9429 (C7orf20) NURSA Protein Complexes 1.0 null PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NLS-Unnamed_1_ZNF385A Rummagene Transcription Factor Associations 2026 1.0 null CRCGN016_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.14598 TE-6 COSMIC Cell Line Gene Mutation Profiles 1.0 null SPI1_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE186810,GSE186813_7_v_5_furin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Lethargy DisGeNET Gene-Phenotype Associations 1.0 null H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE224556,GSE224557_6_v_1_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCIH508 CCLE Cell Line Gene Expression Profiles 1.0 1.56229 RPL14 Pathway Commons Protein-Protein Interactions 1.0 null Ciliary pocket membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.552 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE196104,GSE196106_2_v_1_vsx2_mouse RummaGEO Gene Perturbation Signatures 1.0 null DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2191 TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.8977 biofilm TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.415434 H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QCQG-0126-SM-48U27 GTEx Tissue Sample Gene Expression Profiles 1.0 0.857589 Opisthotonus DisGeNET Gene-Phenotype Associations 1.0 null BRD-K87447060 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20531 Progressive supranuclear palsy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.035 3447_GNL3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.632655 BRD-A25687296_EMETINE_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DDX17 Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NFYA ENCODE Transcription Factor Targets 1.0 null GSE147876,GSE147877_2_v_11_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K73573019 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19796 abnormal retina outer nuclear layer morphology MGI Mouse Phenotype Associations 2023 1.0 null 18786252-TableS1 GeneSigDB Published Gene Signatures 1.0 null GSE101546_3_v_5_setdb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null JUN ENCODE Transcription Factor Targets 1.0 null LNCAP Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.23628 ion binding GO Molecular Function Annotations 2015 1.0 null GSE207582_2_v_1_testosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null K562_Mercaptopurine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0193096 HCC1937 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.661504 GTEX-WFJO-1926-SM-3GILA GTEx Tissue Sample Gene Expression Profiles 1.0 0.977573 central gray of the pons, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.11634 IRS2_KO_GDS1219_304_mouse_brown preadipocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20F-06A-21R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Defective HLCS causes multiple carboxylase deficiency Reactome Pathways 2024 1.0 null GSE147056_3_v_1_actl6b_mouse RummaGEO Gene Perturbation Signatures -1.0 null RPL26 Pathway Commons Protein-Protein Interactions 1.0 null KINGS-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-QEG4-0006-SM-2I5FY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10734 GTEX-P4PP-1526-SM-3P61M GTEx Tissue Sample Gene Expression Profiles 1.0 1.25382 GSE220520_1_v_2_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K73176613 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38107 AE-95-UU45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.205081 nfe2l2_00000000_neonate_p3_lung_lof_mouse_gpl1261_gse29632 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.447923 BICR22_UPPER_AERODIGESTIVE_TRACT CCLE Cell Line Proteomics 1.0 2.80043 MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r10 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45113 different GeneRIF Biological Term Annotations 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WO-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Cardiovascular system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 TLX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.2022 H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ntera2 HPA Cell Line Gene Expression Profiles -1.0 -1.04053 BRD-A25687296_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K81473043_-666_MDST8_6.0_h_0.35_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.04266 GSE190681_1_v_0_rtcb_mouse RummaGEO Gene Perturbation Signatures -1.0 null Cerebral gray matter TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.597 GSE250534_0_v_3_cabergoline_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE188870,GSE188871_0_v_5_kat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null RAD21_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease Reactome Pathways 2014 1.0 null HSF1_KD_GDS1733_754_human_HeLa cells - 0 Hour by siHSF1_2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null eRF1 methyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.032 FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Chemically-Induced Liver Toxicity DisGeNET Gene-Disease Associations 1.0 null Perturb_6046_KD_PES1_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 JAR Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.07556 GSE197850_4_v_2_glucagon_human RummaGEO Drug Perturbation Signatures -1.0 null Biotinidase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.801 SMC4 Pathway Commons Protein-Protein Interactions 1.0 null HSC-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.552 GTEX-WEY5-1926-SM-3GIL8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32847 APLP2_KO_GDS4414_536_mouse_adult cortex GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Kidney Chromophobe_KICH_TCGA-KN-8425-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.75489 Macropinocytic cup COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.721 GSE148066,GSE157787_8_v_7_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04162 Left middle cerebral artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.712 NCI-H1781 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.17075 SNRPF Pathway Commons Protein-Protein Interactions 1.0 null Basomedial amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21546 Meynert's basal nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.749 ARH-77 COSMIC Cell Line Gene Mutation Profiles 1.0 null Nigrostriatal system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.711 GSE154219_0_v_2_cholestyramine_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TBX20-22080862-HEART-MOUSE ChEA Transcription Factor Targets 2022 1.0 null NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.49902 COV504 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27765 respiratory insufficiency HPO Gene-Disease Associations 1.0 null PMC11711664-41598_2025_85366_MOESM6_ESM.xlsx-AA-METABOLIC_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null 496100608_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.38243 H3K4me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null NFYB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K96096022 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.33887 SCAR complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.979 Brain - Anterior cingulate cortex (BA24) GTEx Tissue Gene Expression Profiles 2023 -1.0 -2.6306 TAF1_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null KAT2A ENCODE Transcription Factor Targets 1.0 null primary motor cortex (area M1, area 4)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.57584 HNRNPK Pathway Commons Protein-Protein Interactions 1.0 null NCI-H2196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.965412 H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 20018718-TableS2 GeneSigDB Published Gene Signatures 1.0 null GTEX-PSDG-0726-SM-2I5FN GTEx Tissue Sample Gene Expression Profiles 1.0 1.02285 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 digestive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059798 GTEX-SE5C-0626-SM-2XCDV GTEx Tissue Sample Gene Expression Profiles 1.0 0.853208 GTEX-XMK1-1126-SM-4IHJ8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.45603 reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_fibroblast of pedal digit skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Vomiting DisGeNET Gene-Phenotype Associations 1.0 null SMAD3-21741376-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE228413_0_v_3_mavs_mouse RummaGEO Gene Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7374-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null vascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061245 NFYA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040488 YY1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCL11A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.5023 7515_RPS26_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.643653 GTEX-RUSQ-1926-SM-2TF6K GTEx Tissue Sample Gene Expression Profiles -1.0 -0.895764 GTEX-X3Y1-0926-SM-3P5YT GTEx Tissue Sample Gene Expression Profiles 1.0 0.88099 ajmaline-1749 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null structural GeneRIF Biological Term Annotations 1.0 null NRF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZG-0001-SM-47JYF GTEx Tissue Sample Gene Expression Profiles 1.0 0.853112 YY1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.79588 primary motor cortex (area M1, area 4)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.917489 urinary tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.069869 NCIH727 CCLE Cell Line Gene Expression Profiles -1.0 -2.09185 abnormality of the respiratory system HPO Gene-Disease Associations 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null PMC12515692-MOL2-19-2882-s005.xlsx-Proteome_AKT1_AKT2_KD_vs_SCR-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null Diabetes Mellitus CTD Gene-Disease Associations 1.0 1.48042 Intellectual developmental disorder with cardiac arrhythmia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.176 EKVX BioGPS Cell Line Gene Expression Profiles -1.0 -0.978643 BRD-K76713927 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27012 BRD-K93123848_RAF 265_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.80379 GSE182179_2_v_3_kdsr_human RummaGEO Gene Perturbation Signatures -1.0 null H3K79me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Crizotinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0171407 lateral part of r7B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12237 klf4_17017123_rko_gof_human_gpl96_gds1942 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.630842 brain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 inferior olive, medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.859463 CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null alpha-amino acid catabolic process GO Biological Process Annotations 2015 1.0 null GSE210476_2_v_0_rutaecarpine_human RummaGEO Drug Perturbation Signatures 1.0 null HCT-116 COSMIC Cell Line Gene Mutation Profiles 1.0 null Hyperreflexia DisGeNET Gene-Phenotype Associations 1.0 null vestibular nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.20238 BRD-K36031198 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.09839 SW 900 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.863952 H3K79me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K80073743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.81773 GTEX-RWS6-0001-SM-3NMAL GTEx Tissue Sample Gene Expression Profiles 1.0 0.863752 BHLHE40_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE111247_11_v_9_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.934445 H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A97G-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.922856 PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-GM12878_IRF3 Rummagene Transcription Factor Associations 2026 1.0 null MCF7_NVP-BSK805 2HCl_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0131433 PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S23_LF_C1_24h-Unnamed_5_LTF Rummagene Transcription Factor Associations 2026 1.0 null MCF7_Quisinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0131936 BCL11A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-QEG4-0426-SM-33HC3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.903284 PMC6201690__F1 PFOCR Pathway Figure Associations 2024 1.0 null CCN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00535715 Olfactory cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.613 FOS_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.94797 LS-411N COSMIC Cell Line Gene Mutation Profiles 1.0 null branched-chain amino acid metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-XLM4-0004-SM-4AT5I GTEx Tissue Sample Gene Expression Profiles 1.0 1.37646 BRD-K42663584 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69969 GTEX-POMQ-0326-SM-2I5FO GTEx Tissue Sample Gene Expression Profiles 1.0 0.82825 496100337_HIP_possible Alzheimer's disease_no TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.1066 POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A3-KAW COSMIC Cell Line Gene Mutation Profiles 1.0 null r8 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10257 Lung Diseases CTD Gene-Disease Associations 1.0 1.12973 Perturb_13686_KD_LDB1_SRP398635 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Cytosol COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 hsa-miR-548e TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 ANKRD54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69776 GTEX-XUW1-0005-SM-4BOQ7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01942 mediodorsal nucleus of thalamus_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0296 bladder TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.075472 RELB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4854 H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PRPF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55648 NRL_Deficiency_GDS1693_238_mouse_Photoreceptors cells of retinas at P10 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null MCF7_Prednisone_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0132689 urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 GTEX-XAJ8-0226-SM-4GIB2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.26896 SMC3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1897 CCLE Cell Line Gene CNV Profiles 1.0 1.64748 H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Zona incerta TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.633 atp binding GO Molecular Function Annotations 2015 1.0 null H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K34447537 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19766 CRCGN017_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.99868 BGC823 CCLE Cell Line Gene CNV Profiles -1.0 -1.37669 Episodic Metabolic Acidosis DisGeNET Gene-Phenotype Associations 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BICR22 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 parataenial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.988993 BRD-K37356599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41523 HCT-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null HLE Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.46264 NTRK3_drugactivation_67_GSE20358 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 0.957171 OAW-28 GDSC Cell Line Gene Expression Profiles 1.0 1.7721 deep layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.61651 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain InterPro Predicted Protein Domain Annotations 1.0 null AB-25-XU75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237325 H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HINFP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44602 posteroventral (inferior) parietal cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.881193 Drug-Related Side Effects and Adverse Reactions CTD Gene-Disease Associations 1.0 1.46041 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.198 PMC11103890-mmc3.xlsx-ZZZ3_interactors_ESC-2-Gene_names_ZZZ3 Rummagene Transcription Factor Associations 2026 1.0 null heterocycle metabolic process GO Biological Process Annotations 2015 1.0 null MCF7_Trichostatin A_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0164246 6043_PAK1IP1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.664252 BRD-K21582416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3542 KYSE70 CCLE Cell Line Gene Expression Profiles 1.0 1.8343 BRD-K11022796 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53221 GTEX-S4P3-1526-SM-3K2AV GTEx Tissue Sample Gene Expression Profiles 1.0 1.19497 PCMT1 Pathway Commons Protein-Protein Interactions 1.0 null HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.904248 ZNF200 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08051 abnormality of the lung HPO Gene-Disease Associations 1.0 null BRD-K22874335 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69148 GSE158197_2_v_10_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null AF4-26711339-SEM-HUMAN-BLOOD-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null Rectum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 erythroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.177171 GSE48812_9_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null E2F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.2597 G130 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27985 A-VN-1203-2004(H5N1)_Day7-10^3pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.04897 GSE216538_1_v_3_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null catalytic activity GO Molecular Function Annotations 2015 1.0 null oval paracentral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00522 GTEX-WFG7-0001-SM-3P61S GTEx Tissue Sample Gene Expression Profiles 1.0 0.989371 Poisoning CTD Gene-Disease Associations 1.0 1.59357 muscle GTEx Tissue Gene Expression Profiles -1.0 -0.956892 t58-heart_consensus MoTrPAC Rat Endurance Exercise Training 1.0 2.52127 MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100651_FWM_probable Alzheimer's disease_TBI_83_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.05983 medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.80587 GTEX-WK11-2726-SM-3NMAQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.883566 PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NES-Unnamed_1_ZNF385A Rummagene Transcription Factor Associations 2026 1.0 null postcentral gyrus, left, superior lateral aspect of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.856334 Dementia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.35 TestisIntersitial BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.946392 A-Netherlands-602-2009(H1N1)_48Hour_None_GSE40844 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.23612 GSE192689_0_v_2_ricin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-P4QS-0326-SM-2I3EU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831368 JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.831157 Defects in cobalamin (B12) metabolism Reactome Pathways 2014 1.0 null hsa-miR-4306 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 BRD-K12493093 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34611 intracellular organelle lumen GO Cellular Component Annotations 2015 1.0 null A549_GSK J1_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0145696 hyperammonemia HPO Gene-Disease Associations 1.0 null GTEX-OOBK-0005-SM-2YUMG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35703 Prostate adenocarcinoma_PRAD_TCGA-YL-A8HM-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF1-21803131-MONOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null HNRNPA1 Pathway Commons Protein-Protein Interactions 1.0 null H3K36me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.94255 H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HCC1569 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.29504 MZ7-MEL COSMIC Cell Line Gene Mutation Profiles 1.0 null Autosomal recessive nonsyndromic deafness 1A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.803 H4K20me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mesoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.087673 Lung adenocarcinoma_LUAD_TCGA-55-1595-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BHLHE40_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BPIFA3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00521087 BRD-K10696228 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62942 GSE116810_5_v_1_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null IST-MES1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.80835 GTEX-REY6-2426-SM-48FF5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.882808 CCT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91454 H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null COR-L26 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.07205 Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KD-11A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K89141455 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22129 PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1d-List_of_2302_of_genes_differentially_regulated_by_SOX2_FDR_0_1_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null Muscle Hypotonia DisGeNET Gene-Phenotype Associations 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HAND1_cust_neg_HAND1 Rummagene Transcription Factor Associations 2026 1.0 null NCIH1755 CCLE Cell Line Gene CNV Profiles -1.0 -1.33686 POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null MYL6 Pathway Commons Protein-Protein Interactions 1.0 null GSE248501_1_v_0_mst1_mouse RummaGEO Gene Perturbation Signatures -1.0 null mitotic checkpoint complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 2.16101 REST_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1 ENCODE Transcription Factor Targets 1.0 null FOS_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47018 CTCF_WI38_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null agranular insular cortex (area Iag) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.836714 BRD-K99982687 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19224 striatum_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.928036 anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.988828 NCI-H460 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.9754 CRCGN010_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.39503 ZBTB7A ENCODE Transcription Factor Targets 1.0 null RELA_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mccbeta GeneRIF Biological Term Annotations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z2-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WFG7-0005-SM-3GIKM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15881 GSE219103,GSE219104_0_v_1_progesterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null RPLP0 Pathway Commons Protein-Protein Interactions 1.0 null RCC10RGB GDSC Cell Line Gene Expression Profiles -1.0 -1.42024 GTEX-P78B-0005-SM-2I5GM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19441 Defective GIF causes intrinsic factor deficiency Reactome Pathways 2014 1.0 null PMC6061679__F1 PFOCR Pathway Figure Associations 2024 1.0 null Contractile vacuole complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.579 CEBPB_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.64915 DLX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.8658 BronchialEpithelialCells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.14405 POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_CUDC-101_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146426 H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2181 H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOXP2 ENCODE Transcription Factor Targets 1.0 null Congenital Abnormalities CTD Gene-Disease Associations 1.0 1.13449 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Guanidinoacetate methyltransferase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.321 MCF7_Veliparib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158521 GTEX-XYKS-2426-SM-4AT43 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.895549 Perturb_1233_KD_PTBP1_SRP033393 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.60241 SUGP2 Pathway Commons Protein-Protein Interactions 1.0 null brain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057945 Brn3a_KO_GDS1651_248_mouse_Embryonic (day 13.5) trigeminal ganglia - homozygous GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K90882192 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39142 SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.53127 Brain Lower Grade Glioma_LGG_TCGA-TM-A84B-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA2 ENCODE Transcription Factor Targets 1.0 null t70-white-adipose_consensus MoTrPAC Rat Endurance Exercise Training 1.0 1.95948 GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.65669 SG in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.66894 KELLY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.933134 CRCGN012_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.31311 CTCF_fibroblast of lung_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE206729_4_v_0_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null monocarboxylic acid metabolic process GO Biological Process Annotations 2025 1.0 null GSE220520_6_v_4_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null CRCGN017_MCF10A.WT.HP_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.11495 Primary somatosensory area, unassigned, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39707 GSE213588_8_v_4_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null opisthotonus HPO Gene-Disease Associations 1.0 null H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BT-483 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.6775 GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -2.27313 aminotermini GeneRIF Biological Term Annotations 1.0 null Lingula (I) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.12356 NCI-H460 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.986392 MCF7_Alendronate sodium trihydrate_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0180606 mccc1lamp3 GeneRIF Biological Term Annotations 1.0 null GSE227891_5_v_0_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null 7312_RIOK2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.506004 BRD-K16387460 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.855 PMC3805607__F2 PFOCR Pathway Figure Associations 2024 1.0 null NCI-H520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25533 GSE88819_3_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CA46 CCLE Cell Line Gene Expression Profiles 1.0 1.42446 PMC10123531-NIHMS1874945-supplement-Table_S3.xlsx-SOX17_BCAT_cobound_coreg_peaks-Gene_Name_SOX17 Rummagene Transcription Factor Associations 2026 1.0 null biotin carboxylase activity GO Molecular Function Annotations 2015 1.0 null BRD-K13941175 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14235 USF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Taurine dioxygenase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.746 H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE144838_4_v_3_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null layer 3 of LPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01082 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null caudal ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.984786 GSE128844_0_v_3_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE224547_1_v_0_cftr_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K13204142 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18117 CRCGN017_MCF10A.WT.HP_24H:N03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.11922 HS 294T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.899934 GTEX-NFK9-0006-SM-3GACS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56468 Amino acid metabolic disorder DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 5.0 m1AD (DM) part of periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23145 NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100453_HIP_possible Alzheimer's disease_no TBI_88_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.62392 E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 2963_FANCE_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.555313 H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27985 central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.84542 Pharynx TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Cadmium CTD Gene-Chemical Interactions 1.0 null H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.954368 COLO 320DM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.904248 MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA ChEA Transcription Factor Targets 2022 1.0 null GTEX-NPJ8-2226-SM-3TW8D GTEx Tissue Sample Gene Expression Profiles -1.0 -0.882256 KRT33B Pathway Commons Protein-Protein Interactions 1.0 null HTC-C3 COSMIC Cell Line Gene Mutation Profiles 1.0 null SNRPD3 Pathway Commons Protein-Protein Interactions 1.0 null GSE205163,GSE205164_3_v_4_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ABC-1 GDSC Cell Line Gene Expression Profiles 1.0 2.20664 GSE202434,GSE202438_8_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null PMC4590705-13062_2015_86_MOESM1_ESM.xlsx-Gene_A_-_TP53-Unnamed_20_TP53 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_SGI-1776 free base_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0122317 acute myeloid leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.236627 medial subhabenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06528 GSE148692,GSE148695_1_v_0_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.835476 reticulotegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10996 defined GeneRIF Biological Term Annotations 1.0 null GSE149366_1_v_0_sulconazole_human RummaGEO Drug Perturbation Signatures -1.0 null MCF7_ITSA-1_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0165838 CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL36A Pathway Commons Protein-Protein Interactions 1.0 null GTEX-SNMC-0626-SM-4DM6H GTEx Tissue Sample Gene Expression Profiles 1.0 0.985388 NCI 460 BioGPS Cell Line Gene Expression Profiles -1.0 -1.46475 H3K27ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-X88G-0004-SM-47JZ6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07083 BRD-K92022897 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15029 lactic acidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.159302 Lung adenocarcinoma_LUAD_TCGA-62-A46S-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null hs913t TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.957 POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cancer of Colon_Intestine - Large Intestine - Colon (MMHCC)_GSE4107 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.73955 Ventral nucleus of thalamus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.843 Vascular system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 medial habenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08097 POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.23701 HPAFII CCLE Cell Line Gene Expression Profiles -1.0 -1.57451 GTEX-S4Q7-1126-SM-4AD6R GTEx Tissue Sample Gene Expression Profiles 1.0 0.976082 SMARCC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDSR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00372 ACTG2 Pathway Commons Protein-Protein Interactions 1.0 null ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.02827 CCT2 Pathway Commons Protein-Protein Interactions 1.0 null GSE215351,GSE215794_4_v_0_kdm8_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K70648728 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.352 Fatty Liver CTD Gene-Disease Associations 1.0 1.55084 CRCGN017_MCF10A.WT.HP_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7214 tRNA methyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.674 BC-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.60356 MCF7_Panobinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0124123 disease GWASdb SNP-Disease Associations 1.0 0.032827 GSE48812_7_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BD-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148200_1_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE181003_3_v_0_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null PMC12648952-12915_2025_2452_MOESM4_ESM.xlsx-S4c-Pseudobulk_AP2_vs_B57-Unnamed_11_GTF3A Rummagene Transcription Factor Associations 2026 1.0 null DDX6 Pathway Commons Protein-Protein Interactions 1.0 null Laurence-Moon syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.068 ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IZ in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.28478 H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K83229680 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18693 SIN3A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKA2 Pathway Commons Protein-Protein Interactions 1.0 null PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR Rummagene Transcription Factor Associations 2026 1.0 null EN1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.1633 ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BE-01B-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U4B1-0126-SM-4DXSN GTEx Tissue Sample Gene Expression Profiles 1.0 0.868018 PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE182185_0_v_1_pstk_human RummaGEO Gene Perturbation Signatures -1.0 null Malaria DisGeNET Gene-Disease Associations 1.0 null MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null including GeneRIF Biological Term Annotations 1.0 null Perturb_7293_KD_U2AF35_SRP116787 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.38939 GSE203584_1_v_0_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Fetal Death CTD Gene-Disease Associations 1.0 1.34576 PITX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.4331 PMC6981130-41467_2019_14235_MOESM9_ESM.xlsx-FICD_KD-Unnamed_6_AR Rummagene Transcription Factor Associations 2026 1.0 null BRD-K27838482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43468 H3K4me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.33067 GSE235945_1_v_0_pikfyve_mouse RummaGEO Gene Perturbation Signatures 1.0 null USP42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16099 GSE109565_12_v_4_glyphosate_human RummaGEO Drug Perturbation Signatures 1.0 null GSE174418,GSE174421_2_v_3_mettl5_mouse RummaGEO Gene Perturbation Signatures 1.0 null STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE140646_0_v_1_atf3_human RummaGEO Gene Perturbation Signatures -1.0 null KIF5B Pathway Commons Protein-Protein Interactions 1.0 null KYSE-70 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 Adrenal Gland GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.862321 intermediate stratum of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13643 Perturb_6045_KD_NONO_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 PMC3634825__F3 PFOCR Pathway Figure Associations 2024 1.0 null Ventromedial hypothalamic nucleus, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47994 Parkinson's disease GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.35229 POLE3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00538976 GSE102505_4_v_2_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OE33 DepMap CRISPR Gene Dependency 1.0 2.53361 GSE191021_1_v_0_nono_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PW2O-0226-SM-48TC7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.85611 GTEX-PSDG-0005-SM-3GADC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07337 H3K4me1_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null PMC6089552-oncotarget-09-31018-s004.xlsx-compound_targets_chip_rnaseq-Chip-seq_derived_EWS-FLI1_targets_Bilke_et_al_2013_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BFTC-905 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 GTEX-SN8G-0006-SM-32PLD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33577 CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DSP Pathway Commons Protein-Protein Interactions 1.0 null GSE114232_8_v_6_mavs_mouse RummaGEO Gene Perturbation Signatures 1.0 null acid GeneRIF Biological Term Annotations 1.0 null GTEX-UJMC-0726-SM-3GADX GTEx Tissue Sample Gene Expression Profiles 1.0 1.10114 MNAT1_Deficiency - Ablation_GDS2561_689_mouse_Heart - 2 week old GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE139120_1_v_0_urod_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WXYG-2526-SM-3NB3F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.866776 PANC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.973546 PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S15-Table_S15_MR_resluts_of_brain_pQTL_and_small-vessel_stroke_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE193027_1_v_0_krt19_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE100732,GSE100733_0_v_1_lrpprc_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Barrett Esophagus_Esophageal Tissue_GSE1420 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.56661 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.949 GTEX-T6MO-0326-SM-32QOK GTEx Tissue Sample Gene Expression Profiles 1.0 1.05534 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6QY-01A-12R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE169334,GSE169336_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-NPJ8-1626-SM-2HMIY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841596 CYFIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03288 mccb GeneRIF Biological Term Annotations 1.0 null RERF-LC-Sq1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.3693 endometrium HPA Tissue Protein Expression Profiles -1.0 -0.863794 inherited metabolic disorder DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55301 HNF4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2329 GSE74251_0_v_3_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null HCC1143 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.56126 SRSF5 Pathway Commons Protein-Protein Interactions 1.0 null K562_SRT1720 HCl_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0198446 suprachiasmatic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.70265 BRD-K17675924 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85431 ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null CCND1-20090754-RETINA-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.392 Subthalamic nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.706 WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null A-CA-04-2009(H1N1)_48Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.18058 SNU1214 CCLE Cell Line Gene CNV Profiles 1.0 1.57313 SK-OV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.14114 H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Urinary tract TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 RPS26 Pathway Commons Protein-Protein Interactions 1.0 null MYBBP1A Pathway Commons Protein-Protein Interactions 1.0 null GSE149035_1_v_5_hepacam_human RummaGEO Gene Perturbation Signatures 1.0 null TFAP2C ENCODE Transcription Factor Targets 1.0 null MAX_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null post-lysosomal vacuole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.1 Pneumonia CTD Gene-Disease Associations 1.0 1.23106 496100495_FWM_no dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.24634 IGR39 DepMap CRISPR Gene Dependency 1.0 3.17167 MCF7_SNS-314 Mesylate_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0128356 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.075005 bladder GTEx Tissue Gene Expression Profiles 1.0 1.17624 Subcortical maternal complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.54 GATA3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Abnormality Of The Cerebral Vasculature DisGeNET Gene-Disease Associations 1.0 null SNRPD2 Pathway Commons Protein-Protein Interactions 1.0 null NCI-H524 COSMIC Cell Line Gene Mutation Profiles 1.0 null HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.27077 3-Methylcrotonyl Coa Carboxylase 1 Deficiency DisGeNET Gene-Disease Associations 1.0 null BRD-K06203932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79565 membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042432 sporozoan form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.23604 GTEX-OXRP-0226-SM-3NB14 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09411 CRCGN015_MCF10A.WT.HP_24H:N11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.58366 Motor Retardation DisGeNET Gene-Phenotype Associations 1.0 null H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RFX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7192 PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3 Rummagene Transcription Factor Associations 2026 1.0 null leucine metabolic process GO Biological Process Annotations 2023 1.0 null abnormality of the nervous system GWASdb SNP-Phenotype Associations 1.0 0.09961 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2M2-01A-21R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE160817_3_v_8_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K03093950 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07902 CORL24 CCLE Cell Line Gene Expression Profiles -1.0 -1.51221 H3K4me1_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE198434_1_v_0_aspirin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-R53T-0326-SM-48FEC GTEx Tissue Sample Gene Expression Profiles 1.0 1.8936 GTEX-S95S-1326-SM-2XCDK GTEx Tissue Sample Gene Expression Profiles 1.0 1.04577 GSE142210_2_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Pars compacta TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.168 GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39124 NR3C2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.9328 K562_Carmofur_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0157781 amino GeneRIF Biological Term Annotations 1.0 null kidney_c HPA Tissue Sample Gene Expression Profiles 1.0 1.04466 GSE48812_4_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null dorsal motor nucleus of the vagus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.43212 R3HCC1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-U4B1-0006-SM-3DB8E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04786 SERTAD4 Pathway Commons Protein-Protein Interactions 1.0 null KYSE-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.72983 CRCGN015_MCF10A.TP53.M_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.58665 H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RIPPLY3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80558 RUNX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97645 BRD-K90902537 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35472 GSE166536_1_v_2_docetaxel_mouse RummaGEO Drug Perturbation Signatures -1.0 null BRD-K31462164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11759 functional respiratory abnormality HPO Gene-Disease Associations 1.0 null H4K8ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Parkinson Disease dbGAP Gene-Trait Associations 1.0 0.907793 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Carbohydrate metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.407 GSE158182_4_v_0_pnpla3_human RummaGEO Gene Perturbation Signatures -1.0 null A549_PHA-680632_10nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0178657 BRD-K55766625 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65079 K562_Busulfan_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0168434 GSE209598_0_v_3_tgfbr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE149870_0_v_1_pfn1_mouse RummaGEO Gene Perturbation Signatures 1.0 null KCL-22 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE111247_11_v_4_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE226316_6_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Heteromeric SMAD protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.004 Nodulus (X), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22026 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Fasting insulin GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.609691 BRD-K22437400 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.97456 LN-229 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.8647 GTEX-VUSH-0005-SM-3NB2H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58143 BRD-K76515685 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45429 GSE196117_1_v_0_clarithromycin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77915 GTEX-XBEC-1326-SM-4AT69 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0689 methylcrotonoyl-CoA carboxylase complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 fenofibrate_homo sapiens_gpl4044_gse15494 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE206870,GSE206872_0_v_2_ascl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE154350_1_v_0_ascl2_human RummaGEO Gene Perturbation Signatures 1.0 null Subparaventricular zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36224 SARS-CoV MA15_Day7-C57BL6_None_GSE50878 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.6729 blood TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.326067 PRRT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92788 cerebellum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12558 membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.347587 MAFF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE207582_4_v_3_testosterone_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE149880_2_v_1_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null TCF12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE116810_5_v_4_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.30851 MCF7_AC480_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0120945 BRD-K75815721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.45494 periventricular stratum of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.43424 NCF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00457197 GSE226316_4_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.940407 TE5 CCLE Cell Line Gene Expression Profiles 1.0 1.87486 Muscular system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3CC-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FNDC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13541 GATA4-25053715-YYC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02434 Cerebral malaria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.745 ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU2F1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null CRCGN009_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.72158 Adrenocortical carcinoma_ACC_TCGA-OR-A5LS-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-7660-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8763317-MO-018-D1MO00236H-s002.xlsx-PHF21A_S0_2-Gene_names_PHF21A Rummagene Transcription Factor Associations 2026 1.0 null striatum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.926514 GTEX-OHPN-0005-SM-2YUML GTEx Tissue Sample Gene Expression Profiles -1.0 -0.959421 liver_a HPA Tissue Sample Gene Expression Profiles 1.0 0.840215 eGFP-GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the urinary system physiology HPO Gene-Disease Associations 1.0 null disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.324823 epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050683 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 TAF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RTLS-2326-SM-46MUH GTEx Tissue Sample Gene Expression Profiles 1.0 0.960423 K562_Prednisone_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0193062 adult retina HPM Cell Type and Tissue Protein Expression Profiles -1.0 -1.17458 Developmental disorder of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.334 Phosphate HMDB Metabolites of Enzymes 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5788-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPI1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.924791 Perturb_17611_OE_U2AF35_SRP116787 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.9481 Defects in vitamin and cofactor metabolism Reactome Pathways 2014 1.0 null Perturb_1238_KD_SRSF1_SRP033393 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.674 3-isopropylmalate dehydratase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.566 acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.053913 motor nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.16328 synucleinopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.144869 Disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 5.0 PMC11031166-SAG-2302-87_0_Appendix_1_SG_IHDS_(569_genes)_Final_List.xlsx-AP1-Genes_JUN Rummagene Transcription Factor Associations 2026 1.0 null IKZF1 ENCODE Transcription Factor Targets 1.0 null CREB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HLCS Pathway Commons Protein-Protein Interactions 1.0 null sulfur compound metabolic process GO Biological Process Annotations 2015 1.0 null 20368555-TS-1 GeneSigDB Published Gene Signatures 1.0 null CCT3 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-PWOO-0006-SM-2I3E3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18034 primary visual cortex (striate cortex, area V1/17)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.05436 JHH6 CCLE Cell Line Gene CNV Profiles -1.0 -1.62694 MXI1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE246461,GSE246463_5_v_0_mecp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -2.98987 CRCGN008_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3251 GSE232714_0_v_1_raver1_human RummaGEO Gene Perturbation Signatures 1.0 null NFATC1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1-23547873-NB4-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K76900919 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63212 GTEX-WH7G-0726-SM-3NMBM GTEx Tissue Sample Gene Expression Profiles 1.0 1.666 tail of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06201 BRD-K85284710 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75142 r9 part of nucleus gracilis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12805 KYSE140 CCLE Cell Line Gene Expression Profiles 1.0 2.83779 EXOC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06469 BRD-K35527855 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.0099 GTEX-R3RS-0526-SM-3GADG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.865444 demonistrated GeneRIF Biological Term Annotations 1.0 null protein binding GO Molecular Function Annotations 2015 1.0 null cell COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-WQUQ-0006-SM-3MJF4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02647 GSE188870,GSE188871_1_v_5_kat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null emboliform nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.40331 SNRPA Pathway Commons Protein-Protein Interactions 1.0 null DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.66281 Mood disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.482 MITF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30538 Lipid metabolism disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.139 CRCGN011_HEPG2_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3833 PDE6A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00473547 GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HIST1H3B Pathway Commons Protein-Protein Interactions 1.0 null P3HR1 CCLE Cell Line Gene Expression Profiles 1.0 1.41171 MCF7_Resveratrol_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0184917 GSE226249_0_v_8_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null GSE210580_4_v_12_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null amygdalohippocampal transition zone, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2408 IZ in midcingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.18229 BRD-K27229533 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29249 GTEX-S4Z8-0426-SM-3K2AH GTEx Tissue Sample Gene Expression Profiles 1.0 1.77583 ARL6IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28417 GTEX-UPJH-0006-SM-3GACW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14867 described GeneRIF Biological Term Annotations 1.0 null GSE152937_12_v_1_slc16a13_mouse RummaGEO Gene Perturbation Signatures 1.0 null precommissural nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25278 BRD-K30288714 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13297 STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null LBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.1552 E2A-27217539-CHIP-SEQ-RAMOS-CELL-LINE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Perturb_8418_KO_Yap1/Wwtr1_SRP143461 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.70617 CRCGN008_HEPG2_24H:I19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4495 GSE125782_3_v_1_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null TFAP2A ENCODE Transcription Factor Targets 1.0 null Anterior hypothalamic nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41687 H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE119345_2_v_3_bexarotene_human RummaGEO Drug Perturbation Signatures 1.0 null Lymphoid cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.367 marrow cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.071406 GSE121866_0_v_3_six4_human RummaGEO Gene Perturbation Signatures -1.0 null IKZF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10826 GTEX-WY7C-2426-SM-3NB2V GTEx Tissue Sample Gene Expression Profiles 1.0 0.897324 Ornithine carbamoyltransferase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.484 PL45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.833129 SDE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8462 Perturb_17409_KO_Kat7_SRP346204 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.5386 GSE135400_1_v_0_kdm1b_human RummaGEO Gene Perturbation Signatures -1.0 null MSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.4335 TMEM169 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15092 ZBTB33_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD19 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Superior temporal gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.017 RPS19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27141 visual pathway disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.235616 Perturb_6902_KD_Hdac5_SRP257918 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.35862 single-organism catabolic process GO Biological Process Annotations 2015 1.0 null Stat5a::Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.0553 RPS27L Pathway Commons Protein-Protein Interactions 1.0 null 4-aminobutyrate transaminase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.671 ADAMTS16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54301 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73Q-01A-21R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ciliary base COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.676 MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Phenylketonuria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.619 mediodorsal nucleus of thalamus_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.35082 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.135042 IOSE80 BioGPS Cell Line Gene Expression Profiles -1.0 -0.930449 T47D CCLE Cell Line Gene CNV Profiles 1.0 1.48908 Developmental and epileptic encephalopathy 6B DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.199 PMC3479095-pone.0047303.s002.xlsx-AA_catabolism-Gene_name_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null Bed nuclei of the stria terminalis, posterior division, strial extension Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09687 GSE234340_10_v_2_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null USF1_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HA-E2F1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WWYW-1326-SM-3NB2S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.907988 BRD-K41643612 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06862 18081427-TableS8 GeneSigDB Published Gene Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ZP-A9D0-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acquired Immunodeficiency Syndrome HuGE Navigator Gene-Phenotype Associations 1.0 null NFIC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null GTEX-XBEW-0002-SM-4AT5O GTEx Tissue Sample Gene Expression Profiles 1.0 1.23411 Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.8505 PMC12311841-CTM2-15-e70424-s001.pdf-19-GTF2I_intron_GTF2I Rummagene Transcription Factor Associations 2026 1.0 null Amino acid metabolism WikiPathways Pathways 2024 1.0 null GTEX-R53T-1526-SM-48FEK GTEx Tissue Sample Gene Expression Profiles 1.0 1.83004 RC-K8 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE88819_5_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null NTRK2_drugactivation_66_GSE20358 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 0.957171 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MCF7_Pelitinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0244858 GSE88819_11_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null A498 BioGPS Cell Line Gene Expression Profiles -1.0 -1.87404 TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RMG-I Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.35665 GSE220520_3_v_4_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null GLUD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01004 MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K38190084 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51156 GTEX-U8XE-1026-SM-4E3HM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03384 SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.2208 Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FS-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lewy neurite COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.247 ovary HPA Tissue Protein Expression Profiles -1.0 -1.38159 COLO668 CCLE Cell Line Gene Expression Profiles 1.0 1.54287 H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null L-leucine metabolic process GO Biological Process Annotations 2025 1.0 null SLX9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07764 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.985368 GFI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.5897 KNS-62 COSMIC Cell Line Gene Mutation Profiles 1.0 null RPL7A Pathway Commons Protein-Protein Interactions 1.0 null occipital lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.33965 VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.42477 20068109-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null VIIIA, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.830684 GSE65617_2_v_1_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE139540_0_v_2_menadione_human RummaGEO Drug Perturbation Signatures 1.0 null PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K41289356 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.01759 GSE158182_3_v_0_pnpla3_human RummaGEO Gene Perturbation Signatures -1.0 null ECH1 Pathway Commons Protein-Protein Interactions 1.0 null 4908_MCOLN1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.753454 WM793B COSMIC Cell Line Gene Mutation Profiles 1.0 null BL2512 (TLK2) NURSA Protein Complexes 1.0 null GTEX-RUSQ-0326-SM-47JWS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.990024 BRD-K99097591 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03958 MYC ENCODE Transcription Factor Targets 1.0 null BRD-K29935988 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54284 Cognition Disorders CTD Gene-Disease Associations 1.0 1.41063 H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null adiposetissue BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.18124 Uterine endometrium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.872913 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ED-81-ZH14_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.286517 GSE174498,GSE174500_0_v_1_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null AN3-CA COSMIC Cell Line Gene Mutation Profiles 1.0 null ADP HMDB Metabolites of Enzymes 1.0 null H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_1229_KD_HNRNPK_SRP033393 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -14.7606 POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cognitive disorder GWASdb SNP-Disease Associations 1.0 0.799893 GSE87617_1_v_0_ascl1_human RummaGEO Gene Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A82E-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Entorhinal area, lateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.60026 K562_Resveratrol_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159712 nucleoside phosphate binding GO Molecular Function Annotations 2015 1.0 null paracentral lobule, posterior part, left, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.42806 kidney TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.076814 H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K66555411_-666_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K09378334 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14393 disease of mental health GWASdb SNP-Disease Associations 1.0 0.049317 SW780 GDSC Cell Line Gene Expression Profiles 1.0 1.80971 U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01716 GSE203308_4_v_3_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null hippocampus (hippocampal formation)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04566 IRS4 Pathway Commons Protein-Protein Interactions 1.0 null sitedirected GeneRIF Biological Term Annotations 1.0 null RHOXF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.8133 496100514_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.38854 MCF7_Lomustine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0199848 Oral mucosa TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE157594_3_v_2_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null USF1_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Ivosidenib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0179483 HCFC1_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8791942-41398_2021_1766_MOESM7_ESM.xlsx-LPS_DEGs_Heatmap-GeneID_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE242199_9_v_3_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.044711 Schizophrenia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.616 GSE182680,GSE182683_7_v_9_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-S7PM-0006-SM-3NM8C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20776 5182598-868 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE112762,GSE112767_2_v_0_dgcr8_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE242083,GSE242098_3_v_1_med1_human RummaGEO Gene Perturbation Signatures 1.0 null SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE133516_5_v_6_kat7_human RummaGEO Gene Perturbation Signatures -1.0 null fat_e HPA Tissue Sample Gene Expression Profiles 1.0 1.40692 USF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K26508889 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0163 trachea BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.28205 SMAD3-21741376-HESC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null LMO2-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ ENCODE Transcription Factor Targets 1.0 null GSE193258,GSE193259_2_v_6_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-P4PQ-1026-SM-3NMCN GTEx Tissue Sample Gene Expression Profiles 1.0 0.957359 GSE147876,GSE147877_2_v_10_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142210_4_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null abnormality of movement HPO Gene-Disease Associations 1.0 null NCI-H1770 GDSC Cell Line Gene Expression Profiles -1.0 -1.4763 NCI-H1355 GDSC Cell Line Gene Expression Profiles -1.0 -1.59046 GSE196540,GSE196542_2_v_0_dnmt3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null factors GeneRIF Biological Term Annotations 1.0 null 1469_CEBPG_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.618861 MCF7_Resveratrol_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0191779 GSE44157,GSE44163_3_v_0_nr6a1_mouse RummaGEO Gene Perturbation Signatures 1.0 null AX-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.057 H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K96120749 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.02511 GSE137144_5_v_7_nlrp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KC-11A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Kidney Injury CTD Gene-Disease Associations 1.0 1.08726 MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null four GeneRIF Biological Term Annotations 1.0 null GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles -1.0 -2.09768 mantle zone of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12402 GSE188458_2_v_4_hydrogen peroxide_human RummaGEO Drug Perturbation Signatures -1.0 null purine nucleotide binding GO Molecular Function Annotations 2015 1.0 null GTEX-OHPL-1326-SM-3MJGG GTEx Tissue Sample Gene Expression Profiles 1.0 0.848216 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RE-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Dendritic lamellar body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.955 HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.81211 alleles GeneRIF Biological Term Annotations 1.0 null Rectum adenocarcinoma_READ_TCGA-DY-A1DC-01A-31R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1836 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE157777_1_v_3_foxa3_mouse RummaGEO Gene Perturbation Signatures -1.0 null MEF2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.7341 GTEX-UTHO-1026-SM-3GAF7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.23363 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5696-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MATR3 Pathway Commons Protein-Protein Interactions 1.0 null GSE255432_7_v_3_imeglimin_mouse RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4 ENCODE Transcription Factor Targets 1.0 null LXR-22292898-THP-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ATF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.4185 2-phenylmelatonin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46807 NCIH1436 CCLE Cell Line Gene Expression Profiles 1.0 2.06292 HEL DepMap CRISPR Gene Dependency 1.0 2.09157 parasitic protozoa infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.170544 rs11711441 GeneRIF Biological Term Annotations 1.0 null GSE205163,GSE205164_3_v_7_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.916622 H1FX Pathway Commons Protein-Protein Interactions 1.0 null CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Single hybrid motif InterPro Predicted Protein Domain Annotations 1.0 null BRD-A84764193 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01751 GSE125007,GSE125008_4_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Respiratory Insufficiency DisGeNET Gene-Phenotype Associations 1.0 null Hemorrhage CTD Gene-Disease Associations 1.0 1.04352 H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_7900_KO_FOXM1_SRP345649 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.63236 MCF7_EED226_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0130751 USF1 ENCODE Transcription Factor Targets 1.0 null BRD-K23064726 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38202 CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U4B1-1726-SM-3DB9F GTEx Tissue Sample Gene Expression Profiles 1.0 0.949686 GSE144115_2_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE206729_2_v_0_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null LCLC97TM1 DepMap CRISPR Gene Dependency 1.0 2.02721 PMC4335056-pone.0116726.s005.xlsx-Biol_2_QE_NOT_FT-GENE_Official_symbol_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-P4PQ-0526-SM-2HMKR GTEx Tissue Sample Gene Expression Profiles 1.0 0.892952 autosomal recessive inheritance HPO Gene-Disease Associations 1.0 null mitochondrial part GO Cellular Component Annotations 2015 1.0 null S100A7 Pathway Commons Protein-Protein Interactions 1.0 null PMC8914022__F1 PFOCR Pathway Figure Associations 2024 1.0 null POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K54554531 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03334 intracellular organelle lumen GO Cellular Component Annotations 2025 1.0 null GSE195663_0_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K70198986 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65815 BRD-K16279128 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57336 ACF complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.095 mantle zone of r2BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03611 H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SPI1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null Rfx6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.88 ILF2 Pathway Commons Protein-Protein Interactions 1.0 null ARID3A ENCODE Transcription Factor Targets 1.0 null placenta_6c HPA Tissue Sample Gene Expression Profiles -1.0 -0.901154 CRCGN010_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.22484 HC-74-HM63_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.222734 EP300_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD7 ENCODE Transcription Factor Targets 1.0 null NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.42146 NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.38652 BRD-K90881556 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41835 GSE180185_4_v_10_setbp1_human RummaGEO Gene Perturbation Signatures -1.0 null Field CA2, stratum lacunosum-moleculare Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50539 H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE107505_3_v_2_nanog_mouse RummaGEO Gene Perturbation Signatures 1.0 null CHD7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null leucine metabolic process GO Biological Process Annotations 2015 1.0 null NCIH1781 CCLE Cell Line Gene Expression Profiles 1.0 1.41081 POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Autosomal genetic disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 5.0 POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Parkinson's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.98 17683518-813GeneTable GeneSigDB Published Gene Signatures 1.0 null urine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.700262 PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-D1-D3_643_AR-DEGs-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K79me2_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KRT2 Pathway Commons Protein-Protein Interactions 1.0 null PMC8791942-41398_2021_1766_MOESM7_ESM.xlsx-LPS_DEGs_Heatmap-hgnc_symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null M-1 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.03165 TEAD4_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055601 USF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN010_HEPG2_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1558 USF2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K70518736 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06371 MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TCF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.2019 soft tissue HPA Tissue Protein Expression Profiles -1.0 -2.15828 GSE176008_0_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_MCF10A.WT.HP_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.55147 BRD-K44807762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.61733 EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ADGRL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71574 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE248769_1_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-V955-0005-SM-3P5ZC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61097 GSE48812_3_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K69396470 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02203 K562_AG-490_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0190861 GSE195568_6_v_10_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null Cingulate cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.151 GSE147876,GSE147877_4_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE239844_6_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-SNOS-0006-SM-32PLH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32014 MCF7_Tozasertib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.022491 Perturb_16933_OE_Hlx_SRP070641 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GSE261563_6_v_1_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null KNS-62 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 GTEX-SSA3-0005-SM-32QOT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01719 BRD-K92241728 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47845 PABPC4 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QEG5-1126-SM-33HC2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18853 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.14267 NRF1 ENCODE Transcription Factor Targets 1.0 null Tyrosinemia type III DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.352 intermediate isthmic part of the dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09123 orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.90154 PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36237 ESS-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-U3ZH-0002-SM-3NMDD GTEx Tissue Sample Gene Expression Profiles 1.0 1.32082 SP1 ENCODE Transcription Factor Targets 1.0 null GSE153189_1_v_3_interferon gamma_mouse RummaGEO Drug Perturbation Signatures -1.0 null NFYA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-375 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27985 organic acid catabolic process GO Biological Process Annotations 2015 1.0 null BRD-K64180195 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23434 urinary system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-W5X1-1426-SM-3GIKH GTEx Tissue Sample Gene Expression Profiles 1.0 1.90152 HIST1H2AD Pathway Commons Protein-Protein Interactions 1.0 null GTEX-SIU7-0926-SM-4BRX1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11087 BRD-K13901498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.498 E2F6 ENCODE Transcription Factor Targets 1.0 null amino acid metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.30226 Superior frontal gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.534 intermediate portion of DFC (area 9/46) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19095 hsa-miR-185 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GTEX-QESD-2026-SM-447BI GTEx Tissue Sample Gene Expression Profiles 1.0 0.978568 LDHB Pathway Commons Protein-Protein Interactions 1.0 null 7513_RPS24_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.592519 GTEX-Q2AG-0005-SM-33HBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36793 H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GE-47-OO30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.313664 GSE48812_4_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null GSE140651,GSE140653_5_v_7_med1_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS-SULTAN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.901556 GTEX-XOT4-0005-SM-4B64S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20992 GSE228106_0_v_5_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null 496100577_FWM_probable Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.0547 NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.92918 CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149123,GSE149128_2_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_epithelial cell of proximal tubule_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal part of JcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07635 FOXA2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A2C5-01A-12R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53571 C6orf47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64491 Medial temporal lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.074 GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles -1.0 -2.29238 GAPDH Pathway Commons Protein-Protein Interactions 1.0 null Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.341 GSE130217_0_v_3_sesn2_mouse RummaGEO Gene Perturbation Signatures -1.0 null YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K41895714_AS-605240_HT29_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03358 RFX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r3BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03547 MCF7_Roxadustat_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0127151 RPL8 Pathway Commons Protein-Protein Interactions 1.0 null HCC1359 CCLE Cell Line Gene Expression Profiles -1.0 -2.79319 POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_MC1568_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0251989 HS 294T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.896032 striatum_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.05334 LENG8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36356 TRIM28_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_14902_KO_Cdkn2a/Nf2/Bap1_SRP199809 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.53086 MCF7_CUDC-907_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0130112 principal sensory nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.84952 head TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE235701,GSE261434_2_v_3_enasidenib_human RummaGEO Drug Perturbation Signatures -1.0 null H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TUBA1C Pathway Commons Protein-Protein Interactions 1.0 null GTEX-TKQ1-0003-SM-3NMAE GTEx Tissue Sample Gene Expression Profiles 1.0 1.2894 CB-16-SY72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.290063 GTEX-OHPL-0006-SM-3MJHB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46888 PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_Symbol_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-UPIC-0002-SM-3NMDC GTEx Tissue Sample Gene Expression Profiles 1.0 1.81528 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5711-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE205316,GSE205317_0_v_3_nrip1_mouse RummaGEO Gene Perturbation Signatures 1.0 null embryonic stem feeder layer BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.37634 mitochondrial matrix GO Cellular Component Annotations 2025 1.0 null CRCGN015_MCF10A.TP53.M_24H:H19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0085 COV362 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.01445 MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12571 PRDX1 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_retinal pigment epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-5R-AA1D-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K09597785 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16265 hepatic steatosis HPO Gene-Disease Associations 1.0 null external granular (germinal) layer of upper rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.907308 Systemic primary carnitine deficiency disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.714 captopril_mus musculus_gpl1261_gds3683 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 7516_RPS27A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.590511 Axon hillock COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.578 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S12_LF_C1_8h-Unnamed_5_LTF Rummagene Transcription Factor Associations 2026 1.0 null SARS-CoV MA15_Day4-TNFRsf1b KO_None_GSE40824 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.90862 Lateral reticular nucleus, magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24969 POLR2A_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cardiovascular Diseases CTD Gene-Disease Associations 1.0 1.01512 Biotin carboxylation domain InterPro Predicted Protein Domain Annotations 1.0 null Tobacco Use Disorder HuGE Navigator Gene-Phenotype Associations 1.0 null BRD-K93034159_2-chloro-2-deoxyadenosine_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-U3ZN-0826-SM-4DXSZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.47913 NFYB ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-VP-A87H-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.6654 ASCL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.2472 posterior (caudal) superior temporal cortex (area 22c)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0955 ventrolateral prefrontal cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.22213 MBD4_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPP2R1A Pathway Commons Protein-Protein Interactions 1.0 null Uterus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.866325 EBF1 ENCODE Transcription Factor Targets 1.0 null GSE131798,GSE131804_2_v_0_igf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null TRIM28 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30183 POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Contractile vacuole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.694 branched-chain amino acid metabolic process GO Biological Process Annotations 2025 1.0 null GSE221633_0_v_1_trim24_human RummaGEO Gene Perturbation Signatures -1.0 null HS578T BioGPS Cell Line Gene Expression Profiles 1.0 1.02876 AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A8YI-01A-21R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CNIH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48489 mantle zone of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07544 MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Hyperammonemia DisGeNET Gene-Phenotype Associations 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6N0-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mccc1 GeneRIF Biological Term Annotations 1.0 null BRD-K08179047 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3749 G61 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.985368 TE441T CCLE Cell Line Gene Expression Profiles -1.0 -1.87252 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null KRT16 Pathway Commons Protein-Protein Interactions 1.0 null 6652_PPP1R10_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.71565 GSE180200,GSE180201_15_v_11_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XMK1-0926-SM-4B66X GTEx Tissue Sample Gene Expression Profiles 1.0 1.37942 Muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.819 H3K4me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE226285_3_v_1_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null coenzyme GeneRIF Biological Term Annotations 1.0 null Ventromedial hypothalamic nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55241 6574_POP1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.511989 inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.879993 GTEX-S4Z8-0006-SM-3K2AQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25988 POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Right atrium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.705 GSE148200_4_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-A17902629 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56863 LTBR_INHIBITION - 1 Day_GDS2005_728_mouse_Lymph nodes (MG-430B) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PMC8764032__F4 PFOCR Pathway Figure Associations 2024 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RM-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Apnea DisGeNET Gene-Phenotype Associations 1.0 null HIST1H2AB Pathway Commons Protein-Protein Interactions 1.0 null POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE89032,GSE89033_0_v_1_sfpq_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100278_FWM_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.73938 GSE65617_5_v_1_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04739 BRCA1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.325001 Paracentral lobule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.773 GTEX-XGQ4-2226-SM-4AT4Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.845149 GSE206516,GSE206518_3_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null 1651_CLEC2L_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.500947 GSE143499_0_v_1_gata6_human RummaGEO Gene Perturbation Signatures -1.0 null EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.975065 canthaxanthin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.94038 CA46 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.28779 BRD-K65602491 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02518 GSE244710_1_v_0_srsf1_human RummaGEO Gene Perturbation Signatures 1.0 null Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part, lateral zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19327 PARD6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02729 GTEX-QMRM-1726-SM-2S1QG GTEx Tissue Sample Gene Expression Profiles 1.0 1.24919 leucine catabolic process GO Biological Process Annotations 2023 1.0 null K562_Sirtinol_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0186326 organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Complicated Malaria DisGeNET Gene-Disease Associations 1.0 null KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.81291 Mitochondrial alpha-ketoglutarate dehydrogenase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.584 rostral division of VL Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.78038 preweaning lethality, complete penetrance IMPC Knockout Mouse Phenotypes 1.0 null GSE179880_10_v_13_e2f4_mouse RummaGEO Gene Perturbation Signatures -1.0 null YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDAMB436 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.876843 r1 part of dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49472 interpositus (intermediate) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.919691 Biotin transport and metabolism Reactome Pathways 2024 1.0 null shell of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1331 ZNF217 ENCODE Transcription Factor Targets 1.0 null r8 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12995 SKIV2L2 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A560-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QDVJ-0008-SM-48U2E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.880618 GSE205730,GSE205731_2_v_0_tazemetostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE157555,GSE157556_3_v_7_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null RAMOS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.930172 KRT31 Pathway Commons Protein-Protein Interactions 1.0 null HCC1187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.896032 parolfactory gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.857211 YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Generalized Hypotonia DisGeNET Gene-Phenotype Associations 1.0 null Lewy body dementia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.318 MAX_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.892896 GTEX-RTLS-0006-SM-2TF58 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13939 RPL35A Pathway Commons Protein-Protein Interactions 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N6-A4VE-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AC-84-QG99_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.202185 H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.20595 CRCGN010_HEPG2_24H:B12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.12318 GSE235066_4_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Malignant mesothelioma of pleura_Pleura_GSE2549 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.78842 POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.14177 GSE235644_1_v_0_fasn_mouse RummaGEO Gene Perturbation Signatures 1.0 null POMGNT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20605 trunk TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058118 5637 CCLE Cell Line Gene Expression Profiles -1.0 -1.56392 medial parabrachial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02355 A-CA-04-2009(H1N1)_24Hour_None_GSE40844 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.80299 TCF12_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.83835 KYSE-140 GDSC Cell Line Gene Expression Profiles 1.0 3.42798 VMRCLCD DepMap CRISPR Gene Dependency 1.0 5.07373 Colitis CTD Gene-Disease Associations 1.0 1.06917 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE48812_8_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null GSE235550_1_v_0_hspa9_human RummaGEO Gene Perturbation Signatures 1.0 null NU-DUL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.21729 MCF7_Temsirolimus_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0176912 CRCGN011_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7347 H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SNRPE Pathway Commons Protein-Protein Interactions 1.0 null SP1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XQ3S-0001-SM-4B64K GTEx Tissue Sample Gene Expression Profiles 1.0 0.889254 YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null organic substance catabolic process GO Biological Process Annotations 2015 1.0 null RPL32 Pathway Commons Protein-Protein Interactions 1.0 null MCF7_PF-3845_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0161502 GSE221577_1_v_5_pik3r1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null upper motor neuron dysfunction HPO Gene-Disease Associations 1.0 null YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.908256 BRD-K92241597_CHR 2797_SKM1_6.0_h_80.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.759 Basis pedunculi cerebri TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.651 BICR18 CCLE Cell Line Gene CNV Profiles 1.0 1.62094 Left ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.913 GSE217526_0_v_1_parthenolide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X4EO-0006-SM-3P5ZF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00852 K562_Aminoglutethimide_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0166547 PMC12405659-CTM2-15-e70437-s001.xlsx-Supplementary_Table_5-BioGrid-interaction_protein_with_MYC_MYC Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null binding GO Molecular Function Annotations 2015 1.0 null POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE163282_12_v_8_aspirin_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZI-0005-SM-2XCED GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12128 H3F3A Pathway Commons Protein-Protein Interactions 1.0 null GSE114992,GSE114993_9_v_2_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE210377_0_v_1_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.404804 SN12C Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.30923 ZMIZ1 ENCODE Transcription Factor Targets 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 excretory gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-PLZ6-1126-SM-3P5ZR GTEx Tissue Sample Gene Expression Profiles 1.0 0.875901 CRCGN016_MCF10A.WT.HP_24H:B13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.22171 ACACA Pathway Commons Protein-Protein Interactions 1.0 null Perturb_2632_KD_SRSF1_SRP297599 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 biotin metabolic process GO Biological Process Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7156-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE146074_0_v_7_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null SOX2-21211035-LN229-GBM ChEA Transcription Factor Targets 2022 1.0 null NCBP2AS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11046 H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Ellagic acid_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0185233 LDHA Pathway Commons Protein-Protein Interactions 1.0 null POU2F2_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVJ-1126-SM-48U1U GTEx Tissue Sample Gene Expression Profiles 1.0 1.00079 Sleep disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.067 Blood vessel TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE160817_7_v_6_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null SOX4 MotifMap Predicted Transcription Factor Targets 1.0 null dorsal endopiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.65819 myoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.118427 YBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02371 ANXA9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69417 GSE144838_1_v_5_egfr_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K20501114 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25615 BRD-K18368161 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23905 NAP1L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05795 PHF20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39941 HIST1H2AC Pathway Commons Protein-Protein Interactions 1.0 null IZ in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.865659 GTEX-XBED-1226-SM-4AT5V GTEx Tissue Sample Gene Expression Profiles 1.0 1.10447 MTA3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Supplementary_Table_9A_The_effects_of_whole_blood_transcripts_on_COVID-19_severity_with_suggestive_Mendelian_randomization_evidence_P_0_05_using_Genomicc_data_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null RPL37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36934 GTEX-T5JW-0926-SM-4DM5K GTEx Tissue Sample Gene Expression Profiles 1.0 0.996618 GSE114992,GSE114993_1_v_2_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.63095 GTEX-OIZI-0726-SM-2XCEI GTEx Tissue Sample Gene Expression Profiles 1.0 0.962128 GSE153871_1_v_2_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PX3G-0006-SM-33HBQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.946102 GSE202434,GSE202438_13_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null 496100452_HIP_possible Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.00796 organelle inner membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 KAT2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04231 20174566-TableS1 GeneSigDB Published Gene Signatures 1.0 null JEKO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 2.65137 GLI3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.7854 EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.903456 Vertebrate muscular system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 TE-441-T Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.15972 A-VN-1203-2004(H5N1)_Day4-10^4pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.23729 CXCL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0207 H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KRT78 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52951 Nasopharynx TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 NFIC::TLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.8125 appendix cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.813873 TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null arsenic trioxide_homo sapiens_gpl201_gse48441 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_D1_vs_D10-hugo_id_MITF Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE158632_2_v_4_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null features GeneRIF Biological Term Annotations 1.0 null GTEX-V1D1-1726-SM-4JBHB GTEx Tissue Sample Gene Expression Profiles 1.0 0.99357 GTEX-UPIC-0926-SM-4IHLV GTEx Tissue Sample Gene Expression Profiles 1.0 0.953096 BRD-K43548664 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00305 major GeneRIF Biological Term Annotations 1.0 null SETDB1_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PXR (PXR:RXR) MotifMap Predicted Transcription Factor Targets 1.0 null inferior frontal gyrus, opercular part, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.988071 EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_2545_KD_BRD4_SRP040136 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 Perturb_6083_KD_UBE2I_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Acute Myeloid Leukemia_LAML_TCGA-AB-2871-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null vitamin binding GO Molecular Function Annotations 2015 1.0 null PDE3B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0053336 GSE114013,GSE114014_1_v_4_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.963274 GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49037 Autosomal recessive disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 5.0 GSE193258,GSE193259_2_v_8_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_HEPG2_48H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.86454 LC1SQSF CCLE Cell Line Gene CNV Profiles 1.0 1.64701 plumule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059659 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null KYSE30 CCLE Cell Line Gene Expression Profiles 1.0 1.70013 H3K27ac_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-WFG7-1826-SM-3GIL1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.838907 leukocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057301 RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A817-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SP1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_5996_KD_BCLAF1_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 molecular GeneRIF Biological Term Annotations 1.0 null Excretory gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 abnormality of the genitourinary system HPO Gene-Disease Associations 1.0 null RPL5 Pathway Commons Protein-Protein Interactions 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-11A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 2731_ESF1_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.579691 mantle zone of r7BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12321 IRF1 ENCODE Transcription Factor Targets 1.0 null global developmental delay HPO Gene-Disease Associations 1.0 null striatum_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.91331 DDX3X Pathway Commons Protein-Protein Interactions 1.0 null Blood metabolite levels GWAS Catalog SNP-Phenotype Associations 1.0 0.910257 GSE186005_1_v_2_klf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-R55D-0826-SM-48FEA GTEx Tissue Sample Gene Expression Profiles 1.0 0.96899 GSE227592_2_v_1_adar_human RummaGEO Gene Perturbation Signatures 1.0 null embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054309 TE-10 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPN-0011-R3A-SM-2I5FC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.936359 DNAJC13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09666 putamen Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32452 GSE188458_2_v_1_hydrogen peroxide_human RummaGEO Drug Perturbation Signatures -1.0 null FA-88-II68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.318996 H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SKA1 Pathway Commons Protein-Protein Interactions 1.0 null promyelocytic leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.685551 BRD-K03923461 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07382 NP8 DepMap CRISPR Gene Dependency 1.0 2.0338 HOXC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16381 SOX2 ChEA Transcription Factor Targets 1.0 null IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Fundus of striatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56636 CRCGN017_MCF10A.WT.HP_24H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.15125 H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.301808 Paraventricular hypothalamic nucleus, magnocellular division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0036 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041793 YWHAB Hub Proteins Protein-Protein Interactions 1.0 null Breast Cancer_Mammary gland_GSE2528 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.24697 MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.96743 RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRSS1 Pathway Commons Protein-Protein Interactions 1.0 null SPI1-23127762-K562-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Muscle TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 TEAD4_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193258,GSE193259_9_v_3_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null paraventricular nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.919887 MCCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27145 RPL23 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32994 SNU668 DepMap CRISPR Gene Dependency 1.0 2.13535 BRD-K00610900 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85393 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.088 RPL7L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2798 BICR22 DepMap CRISPR Gene Dependency 1.0 15.2245 cortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.869105 PMC5097440-12864_2016_3198_MOESM4_ESM.xlsx-Adipose_ind-INDEPENDENT_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null Kidney TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Lipid Metabolism, Inborn Errors HuGE Navigator Gene-Phenotype Associations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-8314-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE130437_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null Fetal Growth Retardation CTD Gene-Disease Associations 1.0 1.26856 MDA-MB-453 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.935782 Calu-3 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.25802 PLIN5_OE_GSE44192_482_mouse_heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A ENCODE Transcription Factor Targets 1.0 null H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null B-lymphoblast TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.519 BRD-K45628030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11459 POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATP MW Enzyme Metabolite Associations 1.0 null PGR-26153859-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Hawkinsinuria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.061 HCC-78 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE216043_3_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Rudiment single hybrid motif InterPro Predicted Protein Domain Annotations 1.0 null TRRAP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00673972 principal sensory nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.947397 GTEX-T2YK-0005-SM-32QOV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11516 H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U3ZN-0002-SM-3NMDF GTEx Tissue Sample Gene Expression Profiles 1.0 1.09046 r9 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40004 BRD-K60483981 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19586 ZPR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38051 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null Perturb_6059_KD_RBM26_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 central nervous system disease GWASdb SNP-Disease Associations 1.0 0.197895 GSE220520_5_v_2_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null HSPA5 Pathway Commons Protein-Protein Interactions 1.0 null Insular cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.424 USF1_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PABPC1 Pathway Commons Protein-Protein Interactions 1.0 null GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Dendritic cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.063 OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.881799 striatum_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12965 GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -2.50879 abnormality of nervous system physiology HPO Gene-Disease Associations 1.0 null RPS6 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-X62O-0008-SM-46MU5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.945336 dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.975141 infection GAD High Level Gene-Disease Associations 1.0 0.293278 PPARA_Deficiency_GDS2934_632_mouse_Small intestine GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-X4EP-0526-SM-3P5YW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.92259 cation binding GO Molecular Function Annotations 2015 1.0 null BRD-K94145457 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47364 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7437-01A-21R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE151612_0_v_2_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE161864,GSE161866_0_v_2_ror2_human RummaGEO Gene Perturbation Signatures -1.0 null IHH-4 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.15433 Dhori Virus_48Hour_20090954_GSE17400 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.74222 CTCF_fibroblast of mammary gland_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K81515704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.59696 7504_RPS15_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.810616 7185_RBM8A_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.11887 SYK_druginhibition_284_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.17662 PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN016_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.99227 r7 part of parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20909 Hematopoietic system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.051 OVKATE Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.29895 H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS11 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null L-leucine catabolic process GO Biological Process Annotations 2025 1.0 null POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE134375_4_v_7_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE242083,GSE242098_2_v_4_med1_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_4490_KO_Pantr2_SRP390021 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.13957 Perturb_1230_KD_HNRNPL_SRP033393 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.27949 DIP2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53545 GSE164874_5_v_10_prednisolone_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE164757,GSE164759_1_v_3_trametinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null Defective MMAB causes methylmalonic aciduria type cblB Reactome Pathways 2014 1.0 null H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08125 protozoan form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.151996 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MP-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE196259_2_v_3_gcm1_human RummaGEO Gene Perturbation Signatures -1.0 null Fumarate reductase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.805 integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050421 embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056226 GTEX-TKQ2-0006-SM-33HBH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12106 MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Andarine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0185869 ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null methylcrotonoyl-CoA carboxylase activity GO Molecular Function Annotations 2023 1.0 null CRCGN013_HEPG2_24H:K03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.77169 MITF ChEA Transcription Factor Targets 1.0 null biotin carboxylase activity GO Molecular Function Annotations 2023 1.0 null SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -3.41306 GTEX-P4PQ-0005-SM-2HMKJ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.18601 posteroventral (inferior) parietal cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.92965 ALX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.3455 Frontal pole, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17415 BRD-K91998226 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9291 hypoglycemia HPO Gene-Disease Associations 1.0 null medial geniculate complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.44569 CREB1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K82674931 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47532 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7430-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral medullary reticular group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.91842 MCF7_Disulfiram_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0129732 hsa-miR-650 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 Perturb_10357_KD_BRD4_SRP093774 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Reactome Pathways 2014 1.0 null Combined oxidative phosphorylation deficiency 7 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.808 USF2 ENCODE Transcription Factor Targets 1.0 null MCF7_RG108_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0155328 Perturb_17199_OE_HER2_SRP166112 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -14.0222 early-onset Parkinson's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.421 GCH1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.608 abnormal embryo size MGI Mouse Phenotype Associations 2023 1.0 null Defects in biotin (Btn) metabolism Reactome Pathways 2014 1.0 null H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U3ZM-0426-SM-3DB73 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0782 ZCCHC8 Pathway Commons Protein-Protein Interactions 1.0 null Hypoglycemia DisGeNET Gene-Disease Associations 1.0 null BRD-K19103580 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.90501 POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null Carbonic acid HMDB Metabolites of Enzymes 1.0 null lateral orbital gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.862244 MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null kidney_a HPA Tissue Sample Gene Expression Profiles 1.0 1.94436 SF268 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.985368 Lewy body-like hyaline inclusion COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.608 MCF7_Alendronate sodium trihydrate_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0144744 GTEX-R55G-2426-SM-2TC5I GTEx Tissue Sample Gene Expression Profiles 1.0 1.12516 china GeneRIF Biological Term Annotations 1.0 null H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 496100538_HIP_no dementia_no TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.82884 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX Rummagene Transcription Factor Associations 2026 1.0 null CTCF_fibroblast of lung_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.962373 Brain Lower Grade Glioma_LGG_TCGA-HT-A5RA-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOS ENCODE Transcription Factor Targets 1.0 null medial trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.89648 H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HSP90AA1 Pathway Commons Protein-Protein Interactions 1.0 null GSE168918_1_v_0_tmprss4_human RummaGEO Gene Perturbation Signatures 1.0 null HIST1H2BF Pathway Commons Protein-Protein Interactions 1.0 null NCI-H1355 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.48111 Birth Weight CTD Gene-Disease Associations 1.0 1.10033 SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null placenta HPA Tissue Gene Expression Profiles -1.0 -1.6633 CDK8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13677 H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03445 Adrenocortical carcinoma_ACC_TCGA-OR-A5J6-01A-31R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JUP Pathway Commons Protein-Protein Interactions 1.0 null KYSE-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.95174 MKN45_STOMACH CCLE Cell Line Proteomics 1.0 4.31774 Defective BTD causes biotidinase deficiency Reactome Pathways 2014 1.0 null Retrosplenial area, lateral agranular part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.25178 GSE242083,GSE242098_3_v_4_med1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WH7G-1126-SM-3NMBK GTEx Tissue Sample Gene Expression Profiles 1.0 1.55774 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.33931 PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4 Rummagene Transcription Factor Associations 2026 1.0 null Biotin transport and metabolism Reactome Pathways 2014 1.0 null ventral tuberomammillary nucleus, superficial part (histaminergic) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.00198 H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XBED-0826-SM-47JYC GTEx Tissue Sample Gene Expression Profiles 1.0 2.0576 GTEX-XMD3-0006-SM-4AT5X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.984802 H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.19033 GSE242199_6_v_3_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KNS-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.930306 BRD-K09720842 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31887 BL6523 (E2F4) NURSA Protein Complexes 1.0 null Heart ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.913 HGC27 CCLE Cell Line Gene CNV Profiles -1.0 -1.49339 GSE121824,GSE121826_0_v_6_scaf8_human RummaGEO Gene Perturbation Signatures -1.0 null TEAD4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease of metabolism DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null CRCGN016_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.1267 UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K19183365 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15341 H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K63277230 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14601 Attention deficit hyperactivity disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.098 PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-Embryo-Hatchling_1272_AR-DEGs-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null kidney TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BL5046 (POLA2) NURSA Protein Complexes 1.0 null CRCGN015_MCF10A.WT.HP_24H:B22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.27369 dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.849724 CREM JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2104 imatinib_homo sapiens_gpl96_gds3048 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-RU72-0226-SM-46MUD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.880917 Caudate putamen TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.167 16715129-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null GSE233256_0_v_1_rbms1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-5942-01A-21R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BCLAF1 ENCODE Transcription Factor Targets 1.0 null T47D GDSC Cell Line Gene Expression Profiles 1.0 2.36685 BRD-K57244822 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.93002 PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA Rummagene Transcription Factor Associations 2026 1.0 null GSE120370_0_v_3_thrombin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Plant tumor tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.636 anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.936883 SPI1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.9203 Bipolar Disorder_Lymphocyte_GSE7036 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.89057 POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4XY-0006-SM-46MV2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08635 A549_Quisinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0127804 GSE149075_6_v_0_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-TML8-0005-SM-32QPA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36485 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-HAND1_neg_targets-Gene_HAND1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WYJK-0826-SM-3NM8Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.836885 BE-27-RQ61_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.252119 GSE179036_1_v_0_trim24_mouse RummaGEO Gene Perturbation Signatures -1.0 null OCIM1 CCLE Cell Line Gene CNV Profiles -1.0 -1.62618 ARRDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3168 CTCF_fibroblast of the aortic adventitia_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F6_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null adult-onset type II citrullinemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.284 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TCF3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-CA-04-2009(H1N1)_24Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.50512 GSE207471_2_v_3_btla_human RummaGEO Gene Perturbation Signatures 1.0 null roof plate of p2 (epithalamic roofplate) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.37959 EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null mccdeficient GeneRIF Biological Term Annotations 1.0 null GSE196699_2_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null SF126 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.93217 bile TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.541773 GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -2.27262 r7 part of the dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65679 GTEX-PLZ6-0226-SM-3P61I GTEx Tissue Sample Gene Expression Profiles 1.0 1.01031 MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ligase activity, forming carbon-carbon bonds GO Molecular Function Annotations 2015 1.0 null MCF7_Alisertib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0146078 PANC 04.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0491 GSE235066_4_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE157594_0_v_7_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE147876,GSE147877_4_v_9_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN014_HEPG2_24H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.23012 GSE261563_0_v_1_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null A-CA-04-2009(H1N1)_24Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.26333 GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.60321 MCF7_BMS-265246_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00986565 BRD-K46994278 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23544 membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null SIN3A_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intellectual disability HPO Gene-Disease Associations 1.0 null PMC12575911-43556_2025_329_MOESM2_ESM.xlsx-SD2_MITF_CoBindingGenes-Gene_MITF Rummagene Transcription Factor Associations 2026 1.0 null RPL36 Pathway Commons Protein-Protein Interactions 1.0 null rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.217258 Hypermethioninemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.545 Kidney renal clear cell carcinoma_KIRC_TCGA-T7-A92I-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE156667_0_v_1_lrrc8a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Parkinson's disease GWAS Catalog SNP-Phenotype Associations 1.0 0.560615 Congenital contractural arachnodactyly DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.377 H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MRPL12 Pathway Commons Protein-Protein Interactions 1.0 null SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.38723 Spasticity, Ctcae DisGeNET Gene-Phenotype Associations 1.0 null Metabolism Reactome Pathways 2014 1.0 null Perturb_7119_KO_Prkce_SRP049245 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.50494 H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SPI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MT-0007-SM-3GACQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.882149 AJUBA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0052812 RPS2 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5587-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K30173809 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42054 H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K01121114_AT-MLPCN CSC-006_PL21_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2A_bone marrow_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 16651409-SuppTable5 GeneSigDB Published Gene Signatures 1.0 null SMARCB1 ENCODE Transcription Factor Targets 1.0 null JUN Pathway Commons Protein-Protein Interactions 1.0 null HCC1395 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.16849 GTEX-X8HC-0006-SM-46MV6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22617 Nde TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.796 REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QV31-1326-SM-2S1QE GTEx Tissue Sample Gene Expression Profiles 1.0 1.08691 cellular_component GO Cellular Component Annotations 2015 1.0 null GTEX-SJXC-0005-SM-2XCE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2118 MCF7_Dacinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00917256 PMC10260405-41588_2023_1409_MOESM6_ESM.xlsx-ST12-Supplementary_Table_12_Most_likely_causal_genes_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WWYW-0005-SM-3NB3K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64954 SW 1463 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.13602 PMC11908325-media-2.xlsx-Table10_MR-Unnamed_7_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null KNS62 CCLE Cell Line Gene CNV Profiles 1.0 1.33611 PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim29_KD-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RT-112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.930172 Sarcoma_SARC_TCGA-MO-A47P-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SK-GT-2 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.23845 FAM136A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03413 Lung squamous cell carcinoma_LUSC_TCGA-85-8355-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 synucleinopathy GWASdb SNP-Disease Associations 1.0 1.54533 CHD1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Biotin deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.543 Field CA2, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07756 GSE227592_13_v_1_adar_human RummaGEO Gene Perturbation Signatures 1.0 null PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Unnamed_1_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GSE102675_3_v_0_atf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null abnormal muscle tone HPO Gene-Disease Associations 1.0 null GTEX-U3ZN-1426-SM-3DB87 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05963 cellular_component COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null parkinson's disease GWASdb SNP-Disease Associations 1.0 1.54533 Adenoma, Liver Cell CTD Gene-Disease Associations 1.0 1.12906 drug-induced hearing loss DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.697 nucleotide binding GO Molecular Function Annotations 2015 1.0 null BRD-K16149312 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02876 RPS20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05058 15260889-TableS2a GeneSigDB Published Gene Signatures 1.0 null TGW GDSC Cell Line Gene Expression Profiles -1.0 -1.47601 mcc GeneRIF Biological Term Annotations 1.0 null Parkinson Disease HuGE Navigator Gene-Phenotype Associations 1.0 null ALB Pathway Commons Protein-Protein Interactions 1.0 null WM-266-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null chr3_183006618_A_G_b38 GTEx eQTL 2025 1.0 1.35647 parkinson's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.987271 Lung squamous cell carcinoma_LUSC_TCGA-66-2794-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_15226_OE_hIGFBP5_SRP337748 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.4601 GSE239688_4_v_0_canagliflozin_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K24124047 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.16662 corpus callosum Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.43127 GTEX-WRHK-0005-SM-3MJF5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31909 one GeneRIF Biological Term Annotations 1.0 null BRD-K90697694 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29725 H3ac_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK ENCODE Transcription Factor Targets 1.0 null Middle temporal gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.438 GTEX-T6MN-0002-SM-3NMAH GTEx Tissue Sample Gene Expression Profiles 1.0 1.43045 GSE201309_5_v_6_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-TML8-0001-SM-3NMAF GTEx Tissue Sample Gene Expression Profiles 1.0 0.923392 GTEX-XQ8I-1126-SM-4BOO2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.58356 Perturb_17169_OE_HER2_SRP166112 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -19.301 RPL24 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null plastid-encoded plastid RNA polymerase complex B COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.745 GSE223241_2_v_0_cdkn2a_human RummaGEO Gene Perturbation Signatures 1.0 null GSE215351,GSE215794_1_v_0_kdm8_mouse RummaGEO Gene Perturbation Signatures -1.0 null MCF7_Lapatinib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0111011 YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE183041_1_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Urinary bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 HIST1H1E Pathway Commons Protein-Protein Interactions 1.0 null 16207381-Table1Sa GeneSigDB Published Gene Signatures 1.0 null organic cyclic compound metabolic process GO Biological Process Annotations 2015 1.0 null H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Ubiquitin activating enzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.718 GSE192870_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE215086_3_v_6_batf_human RummaGEO Gene Perturbation Signatures 1.0 null 7516_RPS27A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.523352 BRD-K60024823 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76879 GSE193999,GSE194000_4_v_0_atf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null VZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.895792 GTEX-UJHI-0006-SM-3DB8H GTEx Tissue Sample Gene Expression Profiles -1.0 -0.901404 EEF1A1 Pathway Commons Protein-Protein Interactions 1.0 null PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null BRD-K69035249 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25683 GSE222758_0_v_1_clofazimine_human RummaGEO Drug Perturbation Signatures -1.0 null B-lymphocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.367 periaqueductal gray substance, ventral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.10776 H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE147876,GSE147877_4_v_8_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null MIXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.2643 Infection by Yersinia enterocolitica_macrophage_GSE2973 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.75697 ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.369861 hsa-miR-193a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 K562_Rucaparib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0169146 SIN3A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K81091703 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10011 GTEX-QV31-0626-SM-447C5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11468 GSE144115_4_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null MZ in posterodorsal (superior) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.936255 PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-Gene_AR Rummagene Transcription Factor Associations 2026 1.0 null hippocampus (hippocampal formation)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.02706 heart ProteomicsDB Cell Type and Tissue Protein Expression Profiles 1.0 1.06288 NELFE_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null B-lymphoblastoid cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.519 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-HAND1_neg_targets-ID_HAND1 Rummagene Transcription Factor Associations 2026 1.0 null EZH2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles -1.0 -2.46943 H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TMMY-0005-SM-33HBN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05596 TE441T CCLE Cell Line Gene CNV Profiles -1.0 -3.08799 core part of DTg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61044 Ovarian Diseases CTD Gene-Disease Associations 1.0 1.10459 GSE163809_1_v_2_sdhaf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE114690_2_v_3_tnfsf14_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE92364_1_v_5_asparaginase_mouse RummaGEO Drug Perturbation Signatures -1.0 null ERH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08022 GTEX-Q2AI-0008-SM-48U2H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09343 layer II of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.37952 H3K79me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of upper leg skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7614775-EMS178742-supplement-Proteomics_Table_1.pdf-120-THAP12_THAP12 Rummagene Transcription Factor Associations 2026 1.0 null IA-76-ZU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.237567 GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38562 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZBTB33_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUZC-1226-SM-4BRVJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.997873 Intraparietal sulcus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.638 H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Muscle Spasticity DisGeNET Gene-Phenotype Associations 1.0 null ATRFLOX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.972988 GSE144231_6_v_5_cxcr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-SNMC-0006-SM-2XCFE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04556 COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06035 GSE65617_5_v_3_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null NFIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.1609 H3K27ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUM-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K84601599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05717 organic cyclic compound binding GO Molecular Function Annotations 2015 1.0 null zona incerta, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13863 erythrocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.401007 carboxylase GeneRIF Biological Term Annotations 1.0 null GTEX-SNOS-0526-SM-4DM54 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32662 r7 part of cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44316 GSE125014_1_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null MCF7_Lenalidomide_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016615 H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K18635665 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16824 r7 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08658 BL9484 (EYA2) NURSA Protein Complexes 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YL-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AD-16-HL96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.434078 carotid artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.423054 MCF7_S3I-201_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0156253 GTEX-TMZS-0006-SM-3DB8G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25804 cerebral gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.32497 Dorsal tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.83855 GTEX-OIZG-0005-SM-2HMJC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.996084 H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ELK1 ENCODE Transcription Factor Targets 1.0 null H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BD-49-MD69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.455509 placenta_3a HPA Tissue Sample Gene Expression Profiles -1.0 -1.22177 GRPEL1 Pathway Commons Protein-Protein Interactions 1.0 null NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.38918 HCC4017 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33622 KARPAS-299 GDSC Cell Line Gene Expression Profiles -1.0 -2.90203 OVCAR-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.934113 BRD-A06471483 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06275 GSE234043_3_v_1_abcb1_human RummaGEO Gene Perturbation Signatures -1.0 null SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JURKAT COSMIC Cell Line Gene Mutation Profiles 1.0 null Nutrition disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.091 5659_NGDN_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.607553 GSE160001,GSE160670_0_v_2_lapatinib_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K76513704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.80439 GSE215086_0_v_2_batf_human RummaGEO Gene Perturbation Signatures -1.0 null IQGAP1 Pathway Commons Protein-Protein Interactions 1.0 null BARHL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.7909 intermediate stratum of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09594 FYN LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00566979 GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34907 basal ganglia disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.682635 U87MG DepMap CRISPR Gene Dependency 1.0 3.30406 monocarboxylic acid metabolic process GO Biological Process Annotations 2023 1.0 null PAX5 ENCODE Transcription Factor Targets 1.0 null DALRD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13325 H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Defective MUT causes methylmalonic aciduria mut type Reactome Pathways 2014 1.0 null GTEX-WHSE-0006-SM-3NMBW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71144 p190 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.58 Methylcrotonyl-CoA carboxylase deficiency ClinVar Gene-Phenotype Associations 2025 1.0 null HEK 293 T-rex BioGPS Cell Line Gene Expression Profiles -1.0 -1.10498 intermediate stratum of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.22218 ASH2L ChEA Transcription Factor Targets 1.0 null CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreas Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.898988 POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE147876,GSE147877_4_v_10_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-NPJ7-0006-SM-3GACR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23399 PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D1FED24h_vs_D1FAST24h_259_AR-DE-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null KRT14 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K61595867 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03308 POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPVG-1026-SM-4B64Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.907347 GATA4 ChEA Transcription Factor Targets 1.0 null BRD-K55218521 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47098 MYBL2 ENCODE Transcription Factor Targets 1.0 null OGT Pathway Commons Protein-Protein Interactions 1.0 null primary motor cortex (area M1, area 4)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16373 7509_RPS19_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.510449 Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.56361 POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-mouse_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null RDES CCLE Cell Line Gene CNV Profiles -1.0 -1.46553 Heart Failure CTD Gene-Disease Associations 1.0 1.18948 Cystic Fibrosis_Intestinal Epithelium_GSE765 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.6034 heterocyclic compound binding GO Molecular Function Annotations 2015 1.0 null K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 2.65102 Lung adenocarcinoma_LUAD_TCGA-86-7953-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular amide metabolic process GO Biological Process Annotations 2015 1.0 null HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.27225 KRT6B Pathway Commons Protein-Protein Interactions 1.0 null GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61206 LCLC103H DepMap CRISPR Gene Dependency 1.0 2.19748 GTEX-VUSG-2626-SM-4KKZI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.865637 DAUDI COSMIC Cell Line Gene Mutation Profiles 1.0 null HNRNPA2B1 Pathway Commons Protein-Protein Interactions 1.0 null PCCB Pathway Commons Protein-Protein Interactions 1.0 null HS 766T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.986392 PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null SCA7_Knock-in_GDS3545_560_mouse_Cerebellum GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8512-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsal thalamus_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.6396 GTEX-WFJO-0326-SM-3GIL3 GTEx Tissue Sample Gene Expression Profiles 1.0 2.71724 H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null EP300_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal pyramidal signs HPO Gene-Disease Associations 1.0 null GSE137177_2_v_0_folic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null mantle zone of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12139 GTEX-R53T-0005-SM-3GADK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.9829 perimammillary part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65474 Adenosine triphosphate HMDB Metabolites of Enzymes 1.0 null CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR2C1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.2826 GTEX-XUZC-1826-SM-4BRVO GTEx Tissue Sample Gene Expression Profiles 1.0 1.71414 IRF3 ENCODE Transcription Factor Targets 1.0 null I-II Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.91589 ZNF395 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27473 FOS JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.3987 HCC2157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.966759 YBX3 Pathway Commons Protein-Protein Interactions 1.0 null HS936T DepMap CRISPR Gene Dependency 1.0 7.25692 H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.860989 SPI1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPIC-0005-SM-3GACV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44888 Serum metabolite levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.70969 FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEF2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7986 GTEX-XPT6-0006-SM-4B66Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.87042 H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary T cells from cord blood Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.87736 eGFP-HDAC8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K22789469 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.93194 RS11846 BioGPS Cell Line Gene Expression Profiles 1.0 1.39191 Lung adenocarcinoma_LUAD_TCGA-05-5423-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF12_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hereditary spastic paraplegia 7 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.372 brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.636708 Cerebral gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.605 BRD-K24877937 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.70526 PMC3919568__F7 PFOCR Pathway Figure Associations 2024 1.0 null mitochondrial matrix GO Cellular Component Annotations 2023 1.0 null HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.965412 Metabolism of vitamins and cofactors Reactome Pathways 2024 1.0 null BRD-K68853384 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03756 GSE152055_0_v_1_mpc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE227592_6_v_1_adar_human RummaGEO Gene Perturbation Signatures 1.0 null Rectum adenocarcinoma_READ_TCGA-CL-5917-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RELA_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K03067624_EMETINE HYDROCHLORIDE_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-WHWD-0826-SM-3LK6R GTEx Tissue Sample Gene Expression Profiles 1.0 1.37823 H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null RECQL4 Pathway Commons Protein-Protein Interactions 1.0 null muscular system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null lateral medullary reticular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19222 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MCF7_ABT-737_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0222199 ribonucleoside binding GO Molecular Function Annotations 2015 1.0 null GSE77108_0_v_7_saha_human RummaGEO Drug Perturbation Signatures 1.0 null GSE202434,GSE202438_15_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null Mucinous intrahepatic cholangiocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.192 GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32017 BRD-K81120201 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.35955 POTEF Pathway Commons Protein-Protein Interactions 1.0 null 5470_NAT10_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.735243 Brain - Hypothalamus GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.63297 Reservosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.531 PMC6858560-NIHMS1538530-supplement-Supplementary_Tables.xlsx-Supplementary_Table_22-Supplementary_Table_22_Aberrant_Splicing_Events_in_TET2_SRSF2_co-mutated_AML_Patients_from_the_Beat-AML_cohort_TET2 Rummagene Transcription Factor Associations 2026 1.0 null Mucosa TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 nervous system disease GWASdb SNP-Disease Associations 1.0 0.106261 GSE169152_3_v_7_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null PRPF40A Pathway Commons Protein-Protein Interactions 1.0 null excretory gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02761 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QLQW-1226-SM-2S1Q9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0078 CREB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.502 KYSE-140 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.26847 SP1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null K562_TAK-901_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0156079 BRD-K32965188 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56312 BRD-K94913508 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12937 POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HIST1H4F Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Entacapone_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0210725 H3K27ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Mitotic checkpoint complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.732 EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.0852 BRD-K96101240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.91328 endometrium_4a HPA Tissue Sample Gene Expression Profiles -1.0 -0.836554 r6 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27253 BHLHE40 ENCODE Transcription Factor Targets 1.0 null KRT9 Pathway Commons Protein-Protein Interactions 1.0 null GSE190186,GSE190188_8_v_10_apoe_mouse RummaGEO Gene Perturbation Signatures -1.0 null amygdaloid complex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.832076 SOX9-24532713-HFSC-MOUSE ChEA Transcription Factor Targets 2022 1.0 null lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.34954 GTEX-RU1J-0006-SM-2TF6M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0452 GTEx Lung 20-29 vs 70-79 GTEx Tissue-Specific Aging Signatures -1.0 -6.08976 GSE212299_3_v_0_abi3_mouse RummaGEO Gene Perturbation Signatures -1.0 null CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null body wall TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.135411 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Epilepsy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.002 Edema CTD Gene-Disease Associations 1.0 1.25494 abnormality of the cerebral vasculature HPO Gene-Disease Associations 1.0 null H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 GSE196540,GSE196542_4_v_0_dnmt3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-Hela_IRF3 Rummagene Transcription Factor Associations 2026 1.0 null GATA3_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -2.52074 RPL31 Pathway Commons Protein-Protein Interactions 1.0 null WC-09-GD62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.33481 GSE236497,GSE236500_1_v_0_pemrametostat_human RummaGEO Drug Perturbation Signatures -1.0 null GSE179031_0_v_2_foxp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null skeletal muscle HPA Tissue Protein Expression Profiles -1.0 -1.38159 nucleus coeruleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20832 RXRA::VDR JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.3 GSE125403_3_v_6_venetoclax_human RummaGEO Drug Perturbation Signatures 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.6014 COV362 CCLE Cell Line Gene Expression Profiles -1.0 -2.99036 Peripheral blood TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.063 GTEX-QEG5-0006-SM-2I5FZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14172 Fatty acid elongase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.658 hippocampus (hippocampal formation)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.1066 GTEX-P4QR-0006-SM-2I5GN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26477 Lung adenocarcinoma_LUAD_TCGA-44-5643-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.813562 YY1-33199912-293T-HUMAN-KIDNEYEMBRYO ChEA Transcription Factor Targets 2022 1.0 null RPL21 Pathway Commons Protein-Protein Interactions 1.0 null TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Fungal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.998 496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.07474 GTEX-PLZ4-1226-SM-2I5FE GTEx Tissue Sample Gene Expression Profiles 1.0 0.873584 BRD-K05041614 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73309 BRD-K98418950 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03454 spleen BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.871442 H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null monocarboxylic acid metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-TKQ1-0006-SM-33HBI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20584 central amygdaloid nucleus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.59948 LIVF001-012 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02173 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.50753 HCC1428 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.747475 UBTF_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJHI-0726-SM-3DB92 GTEx Tissue Sample Gene Expression Profiles 1.0 0.86311 A549_Rucaparib_1然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0127428 GSE239844_8_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null MYB_01_102 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60134 A549_Bisindolylmaleimide IX_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0207877 BRD-K61886116 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23284 CTCF ENCODE Transcription Factor Targets 1.0 null inner CP in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.829607 dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.394 STAT5A ENCODE Transcription Factor Targets 1.0 null PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table5_gnomAD_SAS_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D9-A3Z3-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRKX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10928 FERD3L JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.0536 U118MG DepMap CRISPR Gene Dependency 1.0 2.58063 skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -0.924043 ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 1.20913 H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.962005 Cortical amygdalar area, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47924 BRD-K90157100 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42651 ZNF516 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24379 GTEX-XBEW-0006-SM-4AT4E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57445 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.13629 GSE206729_5_v_1_trps1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PLCD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18119 Gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.063 GTEX-T5JC-0005-SM-4DM7B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51135 Glucosephosphate dehydrogenase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.03 BRD-K76588081 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13079 RPL27A Pathway Commons Protein-Protein Interactions 1.0 null Perturb_8071_KD_SFPQ_SRP281189 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE188870,GSE188871_1_v_2_kat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055821 CTBP2 ENCODE Transcription Factor Targets 1.0 null Peroxisome Biogenesis Disorder DisGeNET Gene-Disease Associations 1.0 null parasitic infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.057724 abnormality of the vasculature HPO Gene-Disease Associations 1.0 null TCF7L2_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1 Rummagene Transcription Factor Associations 2026 1.0 null JURKAT BioGPS Cell Line Gene Expression Profiles 1.0 0.902396 mesothelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.302478 Perturb_12701_KO_Anxa5_SRP379319 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.36844 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null IGROV1 CCLE Cell Line Gene Expression Profiles -1.0 -1.70509 H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Short chain acyl-CoA dehydrogenase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.21 U-2932 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.37073 GSE165689_0_v_1_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL1-Unnamed_0_TAL1 Rummagene Transcription Factor Associations 2026 1.0 null SNU475 CCLE Cell Line Gene CNV Profiles -1.0 -1.54966 EP300_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB33_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X8HC-1626-SM-46MWE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.934999 GSE231524,GSE231526_0_v_1_dusp6_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10793 inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.01188 OCIAML2 CCLE Cell Line Gene Expression Profiles 1.0 1.7738 ACTA2 Pathway Commons Protein-Protein Interactions 1.0 null PMC11908325-media-2.xlsx-Table10_MR-Unnamed_6_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null EEF1A1P5 Pathway Commons Protein-Protein Interactions 1.0 null r9 part of the basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13643 GSE181003_1_v_0_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null NUFIP2 Pathway Commons Protein-Protein Interactions 1.0 null inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.980049 CHD1 ENCODE Transcription Factor Targets 1.0 null H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Mesothelioma_MESO_TCGA-SC-A6LR-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nucleoside binding GO Molecular Function Annotations 2015 1.0 null periventricular stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0442 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.29821 Mitochondrial tricarboxylic acid cycle enzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.39 MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0491 HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.57684 RPL35 Pathway Commons Protein-Protein Interactions 1.0 null TBP_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE223609,GSE223610_0_v_2_kdm6a_human RummaGEO Gene Perturbation Signatures 1.0 null 7538_RPS8_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.07607 HNF1A Pathway Commons Protein-Protein Interactions 1.0 null internal carotid artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.551298 GATA2_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR2F2 ENCODE Transcription Factor Targets 1.0 null GTEX-X88G-0006-SM-47JX5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07668 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null basolateral amygdaloid nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40816 external globus pallidum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19833 Perturb_2551_KD_BRD4_SRP040136 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 FOXA1-33576154-HUMAN-HILARLN-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null HIST1H2AI Pathway Commons Protein-Protein Interactions 1.0 null intermediate stratum of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.01141 GSE235066_4_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Specific developmental disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.248 membrane-enclosed lumen COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 GTEX-POMQ-0008-SM-48TE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.968715 GTEX-VUSG-0008-SM-4KL24 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.888974 PMC7218999__F7 PFOCR Pathway Figure Associations 2023 1.0 null layer 3 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34382 GTEX-XMK1-2526-SM-4B666 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.863254 vitamin c_homo sapiens_gpl570_gds3635 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A9WI-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K15939043 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.81184 GSE186707_1_v_0_hdac4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XBED-0006-SM-47JXO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47789 hsa-miR-548a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 leber hereditary optic neuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.617094 GSE48812_0_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null SNRPB2 Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Glesatinib(MGCD265)_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0105615 GTEX-PWN1-0226-SM-2S1OZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.60151 HIST2H2BF Pathway Commons Protein-Protein Interactions 1.0 null PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_Symbol_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null GATA4-21415370-HL-1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Microbody lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.601 r11 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.94968 ABRAXAS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61404 MCF7_PCI-34051_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152364 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A816-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTF2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7657_SARS_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.561562 NFATC1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PIH1D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1815 upper dorsal perifornical nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32062 GTEX-O5YV-0006-SM-2I5GX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0904 abnormality of the cardiovascular system HPO Gene-Disease Associations 1.0 null primary auditory cortex (core)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.49377 GTEX-WY7C-0006-SM-3NB3L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30017 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HN-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WYJK-1426-SM-3NM8V GTEx Tissue Sample Gene Expression Profiles 1.0 0.946009 H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SOX9-24532713-HFSC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-R55D-0006-SM-3GIJS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.999426 UGCG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11448 eight GeneRIF Biological Term Annotations 1.0 null GSE244072_4_v_6_tfeb_mouse RummaGEO Gene Perturbation Signatures -1.0 null MYC_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r3 pontine raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14648 GTEX-SIU8-0006-SM-2XCE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.973499 GSE135030_8_v_2_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null Sepsis_Hepatic Tissue_GSE1781 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.02851 CHRNA9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5674 H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE65617_2_v_4_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE213588_10_v_5_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null Parahippocampal gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.241 GSE196835_0_v_1_ddx1_human RummaGEO Gene Perturbation Signatures 1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE178714_5_v_7_smad2_human RummaGEO Gene Perturbation Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.866797 A549_Thiotepa_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0158626 H3K79me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 3.24385 GSE139427_2_v_1_ibrutinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC12271601-mmc2.xlsx-OUT_cells_03-Gene_Symbol_TCF23 Rummagene Transcription Factor Associations 2026 1.0 null nervous system disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.682635 ENL-26711339-SEM-HUMAN-BLOOD-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null blood vessel TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Vagina TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K07914894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31073 basomedial amygdaloid nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.59617 Lung adenocarcinoma_LUAD_TCGA-55-7995-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table8_gnomAD_AFR_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null GC-04-UF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.220178 5232_MRPL49_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.556123 Endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.063 H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null seedling TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058719 BRD-K55142307 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05198 GTEX-WVLH-0006-SM-3MJF7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38804 NFYA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3856 PCCA Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE239844_7_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null Amino Acid metabolism(Mus musculus) WikiPathways Pathways 2014 1.0 null GSE128240_0_v_1_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.84221 GSE214596,GSE214598_1_v_0_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PSDG-1626-SM-48TCQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.18856 Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6090-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null deficiency GeneRIF Biological Term Annotations 1.0 null HOS GDSC Cell Line Gene Expression Profiles -1.0 -1.97939 cognitive impairment GWASdb SNP-Phenotype Associations 1.0 0.695693 H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Citrullinemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.672 KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE159678_6_v_3_chloroquine_human RummaGEO Drug Perturbation Signatures -1.0 null MS (Multiple Sclerosis)_CNS - Spinal Cord (MMHCC)_GSE842 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -0.990215 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MCCC2 Pathway Commons Protein-Protein Interactions 1.0 null SETDB1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_6063_KD_RIF1_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hypocotyl TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059372 Perturb_4488_KO_Rnu11_SRP309496 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.77978 PMC7488531-13287_2020_1914_MOESM10_ESM.xlsx-HNF4A_regulated_DEGs_750-Unnamed_1_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null Cotton fibre TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.561 H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K95192796 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16021 fastigial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.24604 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.930531 BC-3 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.77285 GTEX-R55C-0526-SM-3GIKA GTEx Tissue Sample Gene Expression Profiles 1.0 0.860125 disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.682635 HEPG2 DepMap CRISPR Gene Dependency 1.0 2.39566 GSE147876,GSE147877_2_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null excretion GeneRIF Biological Term Annotations 1.0 null MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-Row_names_CENPX Rummagene Transcription Factor Associations 2026 1.0 null GSE121319_1_v_0_gprc5a_human RummaGEO Gene Perturbation Signatures -1.0 null MCF7_Resminostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00784878 MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-34-8456-01A-21R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K11404512 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11948 Mitochondrial metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.206 POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LH-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE171175,GSE171181_1_v_2_e7107_human RummaGEO Drug Perturbation Signatures -1.0 null posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.43498 Extrastriate cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.523 H3K79me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 9689_UVRAG_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.879693 purine ribonucleoside binding GO Molecular Function Annotations 2015 1.0 null lateral nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.06739 NCIH23 CCLE Cell Line Gene CNV Profiles -1.0 -2.25729 TBX20-22328084-HEART-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE157555,GSE157556_0_v_1_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary auditory cortex (core)_25 pcw_F_12948 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.87957 Genetic Predisposition to Disease HuGE Navigator Gene-Phenotype Associations 1.0 null GSE160817_2_v_9_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.275678 Merozoite TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.871 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MTA3 ENCODE Transcription Factor Targets 1.0 null primary motor cortex (area M1, area 4)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.69264 PMC12069319-Table1.xlsx-OCAB_p40_BirA-Gene_Symbol_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null EP300_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 3-Methylbut-2-enoyl-CoA MW Enzyme Metabolite Associations 1.0 null HNRNPR Pathway Commons Protein-Protein Interactions 1.0 null HCFC1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-SNMC-0126-SM-2XCFO GTEx Tissue Sample Gene Expression Profiles 1.0 1.7008 POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR2F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.6633 Familial combined hyperlipidaemia_lymphoblast_GSE1010 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.49482 Perturb_6068_KD_SAFB2_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 UNCX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.2945 Pontine central gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18403 movement disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.200982 BRD-K19534880 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31122 GSE48812_11_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.60928 H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZC3HAV1 Pathway Commons Protein-Protein Interactions 1.0 null GSE147876,GSE147877_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null HOXD12::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.4562 GSE207514,GSE207515_0_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures -1.0 null ZMIZ1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A_48H:F02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5705 GTEX-QXCU-0006-SM-2TC5K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09792 core part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44689 3-methylcrotonyl-CoA carboxylase complex, mitochondrial COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 3.36 Perturb_6004_KD_CEBPZ_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GSE244710_3_v_0_srsf1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -2.15061 H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZC3H11A ENCODE Transcription Factor Targets 1.0 null CRCGN012_HEPG2_24H:J24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.19481 Paraflocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05934 H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pars reticulata TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.531 WM-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Metabolism of vitamins and cofactors Reactome Pathways 2014 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5470-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-V955-2026-SM-3GAFA GTEx Tissue Sample Gene Expression Profiles 1.0 1.04148 GSE239844_4_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-S32W-2226-SM-2XCAY GTEx Tissue Sample Gene Expression Profiles 1.0 1.5968 POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWO3-0005-SM-2I5FS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44567 BRD-K09699976 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19487 Brain Lower Grade Glioma_LGG_TCGA-CS-5395-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE239844_1_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-X585-0005-SM-46MV3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11988 SRSF4 Pathway Commons Protein-Protein Interactions 1.0 null medial mammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.00985 Stat5b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.5674 Lung adenocarcinoma_LUAD_TCGA-86-8280-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.919515 jf1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.673 striatum_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04827 CRCGN015_HEPG2_48H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.99249 BRD-K68435627 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59775 internal globus pallidus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23428 PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S05_LF_C2_3h-Unnamed_5_LTF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WHSB-0326-SM-3LK6K GTEx Tissue Sample Gene Expression Profiles 1.0 1.79668 POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.79413 RPL37A Pathway Commons Protein-Protein Interactions 1.0 null deep layers of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.83983 cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.053146 Perturb_8658_KO_TP53_SRP251281 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 BRD-K89537738 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.42545 rostral ventrolateral reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.15174 MCF7_Givinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00850995 HIST1H2BB Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Daphnetin_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0231305 SNRPD1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null LIFR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0457 GSE213588_8_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE88819_7_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null whole plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052206 anterior orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.61378 Mild cognitive impairment DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.156 FOSL2 ENCODE Transcription Factor Targets 1.0 null ELF1 ENCODE Transcription Factor Targets 1.0 null Biotin HMDB Metabolites of Enzymes 1.0 null t60-adrenal_consensus MoTrPAC Rat Endurance Exercise Training 1.0 1.36563 synucleinopathy DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.682635 GTEX-QDVJ-0005-SM-2TC5X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.933403 BRD-K06243138 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15496 MSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6628 NCIH1355 CCLE Cell Line Gene Expression Profiles -1.0 -1.70292 GSE193258,GSE193259_5_v_15_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null methylcrotonoyl-coa carboxylase activity GO Molecular Function Annotations 2015 1.0 null CTCF_fibroblast of villous mesenchyme_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAEA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49353 nucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.37697 NCI-H929 COSMIC Cell Line Gene Mutation Profiles 1.0 null BCLAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AGS_STOMACH CCLE Cell Line Proteomics 1.0 2.09427 BRD-K93357133 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8603 RASGRF1_KD_GDS2816_287_human_Hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU626 CCLE Cell Line Gene CNV Profiles -1.0 -1.49339 PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Viscus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.063 BRD-K23831817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.92634 genotype GeneRIF Biological Term Annotations 1.0 null CCT7 Pathway Commons Protein-Protein Interactions 1.0 null RPL27 Pathway Commons Protein-Protein Interactions 1.0 null cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4486-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Myosin X complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.674 DKMG CCLE Cell Line Gene Expression Profiles -1.0 -1.58475 CRCGN011_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.57525 H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE191174_0_v_1_ccdc92_mouse RummaGEO Gene Perturbation Signatures 1.0 null KYSE70 CCLE Cell Line Gene CNV Profiles 1.0 2.03849 plant form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056439 FOS_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5451-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RNF168 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68254 LC4-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-O1-A52J-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DA-66-OE69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.34359 GSK3B_knockdown_209_GSE35351 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.74814 GTEX-XGQ4-0226-SM-4GIDS GTEx Tissue Sample Gene Expression Profiles 1.0 1.34066 BLM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62127 K562_UNC0379_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0197251 ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null midbrain reticular formation Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35253 TAF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05737 cerebral malaria DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.347144 primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.6014 Autosomal recessive nonsyndromic deafness DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.106 CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LNCAP BioGPS Cell Line Gene Expression Profiles 1.0 1.67839 anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.13461 MDAMB134VI CCLE Cell Line Gene CNV Profiles -1.0 -2.26795 posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.00135 mediodorsal nucleus of thalamus_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40063 ventrolateral prefrontal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29211 periventricular stratum of r1BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56181 Substantia nigra TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.519 antazoline-1556 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null DMD_Deficiency_GDS2996_614_mouse_Cardiac muscles from 10.5-month (mdx animals) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2875-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Alveolar macrophage cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.761 organelle LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57295 neurodegenerative disease GWASdb SNP-Disease Associations 1.0 0.430705 HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA ChEA Transcription Factor Targets 2022 1.0 null K562_Thalidomide_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162382 Middle frontal gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.305 GSE120415,GSE120447_0_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null mantle zone of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44316 BRD-K23835343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06963 MCF7_Trichostatin A_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0178199 H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RPS5 Pathway Commons Protein-Protein Interactions 1.0 null 7504_RPS15_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.614966 RFX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0827 JHH2 CCLE Cell Line Gene Expression Profiles -1.0 -1.63682 DLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.4372 Anterior amygdalar area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50265 SUP-HD1 COSMIC Cell Line Gene Mutation Profiles 1.0 null PITX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4922 Glucose metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.337 GSE211126_3_v_4_hapln1_mouse RummaGEO Gene Perturbation Signatures -1.0 null AGAP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0181 import GeneRIF Biological Term Annotations 1.0 null MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ASH2L-23239880-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K85720719 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00986 GSE216043_3_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null CCND1-20090754-RETINA-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRSF6 Pathway Commons Protein-Protein Interactions 1.0 null 3-methylcrotonyl-coa carboxylase complex, mitochondrial COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 2.15809 pyruvate family amino acid catabolic process GO Biological Process Annotations 2025 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45W-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE247862,GSE247863_0_v_5_eomes_mouse RummaGEO Gene Perturbation Signatures 1.0 null TRIM28_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33622 GTEX-X5EB-1826-SM-4E3K8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.907164 blood vessel TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063555 planum temporale, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.825493 BRD-K75360899 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05331 Heart - Atrial Appendage GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.59883 anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.61179 nuclear part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.642715 Sarcoma_SARC_TCGA-FX-A3RE-01A-11R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4X-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_5964_KD_SFPQ_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -16.7934 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7414-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r3 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.58348 Anterior hypothalamic nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10498 GSE86507,GSE86509_7_v_1_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5988-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE160083,GSE160084_2_v_0_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.20111 maternal GeneRIF Biological Term Annotations 1.0 null BRD-K47707657 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04586 feeding difficulties HPO Gene-Disease Associations 1.0 null GATA3_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_AC480_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0145183 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.569622 H3K27ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PML_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8430-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null basolateral amygdaloid nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.74122 periventricular stratum of isBI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09123 POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE153484_2_v_0_foxp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-Q734-0126-SM-48U1E GTEx Tissue Sample Gene Expression Profiles 1.0 1.06873 GTEX-S341-0626-SM-4AD5T GTEx Tissue Sample Gene Expression Profiles 1.0 0.909585 GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43452 CRCGN013_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.11837 PMC12019336-41467_2025_58868_MOESM5_ESM.xlsx-Open_peaks_IKAROS_WT-Unnamed_11_IKZF1 Rummagene Transcription Factor Associations 2026 1.0 null Paranodal junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.558 IRF4 ENCODE Transcription Factor Targets 1.0 null GTEX-XUW1-0526-SM-4BOP3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21407 DOV13 CCLE Cell Line Gene CNV Profiles -1.0 -1.7905 FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null upper (rostral) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.28856 DDX21 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OOBJ-0006-SM-2I3F4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19216 MYOG_myocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE150895,GSE150896_0_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null NCIH661 CCLE Cell Line Gene CNV Profiles -1.0 -1.54554 CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SE-0005-SM-2XCEA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.868447 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K26195700 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14539 tobacco use disorder GAD Gene-Disease Associations 1.0 null fastigial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14196 GSE244072_11_v_1_tfeb_mouse RummaGEO Gene Perturbation Signatures -1.0 null r6 part of ventral gigangocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09594 SPI1 ENCODE Transcription Factor Targets 1.0 null Nucleus of the lateral olfactory tract, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.30098 GSE149010_0_v_6_dars2_mouse RummaGEO Gene Perturbation Signatures -1.0 null intermediate stratum of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25812 BATF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE261563_5_v_1_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-A492-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF384_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SIU7-0001-SM-3NMAW GTEx Tissue Sample Gene Expression Profiles 1.0 0.976776 Stomach Smooth Muscle Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.940091 BRD-K81575721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28479 Methylmalonic aciduria and homocystinuria type cblC DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.366 TBP_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4QT-1326-SM-3NMD3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.962734 16715129-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null GSE213588_8_v_11_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K19651468 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08153 FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20-D3_1775_AR-DEGs-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null HS 940.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.938536 GTEX-QLQW-0005-SM-2S1RA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13447 NCIH1435 CCLE Cell Line Gene Expression Profiles -1.0 -1.77116 cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.965058 CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:K12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0333 EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.24279 MCF7_Busulfan_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0204205 PAX5_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9 Rummagene Transcription Factor Associations 2026 1.0 null cSARS Bat SRBD_24Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.70045 CHD7_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P44H-0006-SM-2XCFB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11805 BRD-K95871937 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80194 GSE215086_4_v_6_batf_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.80598 K562_Celecoxib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0176508 WM-115 COSMIC Cell Line Gene Mutation Profiles 1.0 null parkinson disease GAD Gene-Disease Associations 1.0 null Lung adenocarcinoma_LUAD_TCGA-97-8174-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mammillary part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79724 ketonuria HPO Gene-Disease Associations 1.0 null TAL1 ENCODE Transcription Factor Targets 1.0 null GTEX-WFON-1826-SM-3GILG GTEx Tissue Sample Gene Expression Profiles 1.0 1.44864 TAF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SUCS-0226-SM-32PLQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.82954 pseudomyxoma peritonei DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.84544 inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.91249 PMC12830621-41467_2025_67611_MOESM11_ESM.xlsx-Sheet1-Suppl_Data-9_Common_differentially_up-regulated_genes_in_high_vs_low_Mecom_MECOM_mouse_KME_AML_cells_and_human_AML_from_4_public_databases_MECOM Rummagene Transcription Factor Associations 2026 1.0 null PRX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45763 SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hyperkinesis CTD Gene-Disease Associations 1.0 1.03715 carboxylic acid catabolic process GO Biological Process Annotations 2025 1.0 null GTEX-U8XE-0626-SM-3DB8U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07527 Mitochondrial isocitrate dehydrogenase complex (NAD+) COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.524 TAL1::TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5682 PDE10A_KO_GSE40377_581_mouse_Striatum and hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE158182_5_v_7_pnpla3_human RummaGEO Gene Perturbation Signatures -1.0 null HIST1H2AH Pathway Commons Protein-Protein Interactions 1.0 null GSE239373_0_v_1_mettl3_mouse RummaGEO Gene Perturbation Signatures -1.0 null CA-68-KG29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.227335 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZK-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IRF3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBED-0003-SM-47JWP GTEx Tissue Sample Gene Expression Profiles 1.0 1.01761 CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null neurodegenerative disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.682635 H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Ketonuria DisGeNET Gene-Disease Associations 1.0 null Inherited metabolic disorder DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 5.0 GSE94849_1_v_2_pinometostat_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_fibroblast of lung_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H508 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.9032 superficial stratum of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.00198 CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNOS-0003-SM-3NMAO GTEx Tissue Sample Gene Expression Profiles 1.0 1.03333 HIST2H2BE Pathway Commons Protein-Protein Interactions 1.0 null TEAD4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XYKS-0426-SM-4BRW4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.863231 USF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE245270_2_v_5_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_6_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE128730_3_v_6_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE139455_2_v_3_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78599 A498 GDSC Cell Line Gene Expression Profiles -1.0 -1.61493 r2 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04151 H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null USF2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MLF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24568 2932_RIPOR1_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.520917 EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE163282_12_v_2_aspirin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K47694606 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.14497 BRD-K48861177 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29116 POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPV-0006-SM-2TF6Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38954 placenta_6b HPA Tissue Sample Gene Expression Profiles -1.0 -2.63716 head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054401 MCF7_Dasatinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00820635 mitochondrial matrix COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE236437_2_v_3_aldosterone_human RummaGEO Drug Perturbation Signatures -1.0 null CASD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00507 BRD-K43736954_cortisone_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE207514,GSE207515_2_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures -1.0 null SCLC-22H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40969 H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null bonemarrow_5a HPA Tissue Sample Gene Expression Profiles -1.0 -1.50866 BRD-K83895653 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51153 RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KRT5 Pathway Commons Protein-Protein Interactions 1.0 null ATF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.6786 GSE186810,GSE186813_7_v_0_furin_mouse RummaGEO Gene Perturbation Signatures 1.0 null STAT4 MotifMap Predicted Transcription Factor Targets 1.0 null GSE239844_7_v_5_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE149880_0_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null intracellular membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 MZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.46931 GTEX-U3ZN-1226-SM-4DXUD GTEx Tissue Sample Gene Expression Profiles 1.0 2.21122 GSE210101,GSE210114_0_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K91018728 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2392 GSE161846,GSE161849_3_v_0_smarca4_human RummaGEO Gene Perturbation Signatures -1.0 null single-organism metabolic process GO Biological Process Annotations 2015 1.0 null Hypertrophy CTD Gene-Disease Associations 1.0 1.51734 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055609 GTEX-WFON-0001-SM-3P61W GTEx Tissue Sample Gene Expression Profiles 1.0 1.10203 GSE112962,GSE112963_2_v_1_ddx5_human RummaGEO Gene Perturbation Signatures -1.0 null EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.465537 cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.232386 496100372_HIP_dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.6416 mitochondrial membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.075918 H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K34968258_-666_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_fibroblast of skin of abdomen_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null normoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.177171 GSE239844_11_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null NFYB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K81538844_6-(2-Fluoro-benzyl)-2,4-dimethyl-4,6-dihydro-thieno[2,3:4,5]pyrrolo[2,3-d]pyridazin-5-one_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ISTMES2 CCLE Cell Line Gene CNV Profiles -1.0 -1.92706 HNRNPH1 Pathway Commons Protein-Protein Interactions 1.0 null PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_up_VENN-442_common_elements_in_HIF1_peaks_and_HIF1_genes_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null BRD-K57443386 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50261 GTEX-U3ZH-0326-SM-3DB7A GTEx Tissue Sample Gene Expression Profiles 1.0 0.987945 mitochondrial GeneRIF Biological Term Annotations 1.0 null mitochondrial part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.095753 8517_STK24_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.622332 E2F4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.2396 H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYOG ENCODE Transcription Factor Targets 1.0 null GSE244730_0_v_1_erlotinib_human RummaGEO Drug Perturbation Signatures 1.0 null Liver Diseases CTD Gene-Disease Associations 1.0 1.254 MAX_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A79097167 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0564 H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_17329_KO_Dis3l2_SRP288575 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.69384 GSE242367_1_v_0_dpp9_human RummaGEO Gene Perturbation Signatures 1.0 null Chromosome 3q29 microduplication syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.014 ZNF143 ENCODE Transcription Factor Targets 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-L1-A7W4-01A-12R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GM12878 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.6586 H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Skin - Sun Exposed (Lower leg) GTEx Tissue Gene Expression Profiles 2023 1.0 2.48691 GSE192870_2_v_0_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_9867_Mut|KD_SRSF2_SRP368113 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.41092 Prdm14 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.5367 GSE164521_0_v_1_nitric oxide_mouse RummaGEO Drug Perturbation Signatures -1.0 null BRD-K68330990 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.30406 PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null nausea and vomiting HPO Gene-Disease Associations 1.0 null organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 BRD-K96627018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11508 GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66573 MZ in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.69139 GTEX-RM2N-0126-SM-48FDD GTEx Tissue Sample Gene Expression Profiles 1.0 2.25441 CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:K03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.09701 H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 7720_SDF2L1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.505038 Perturb_4713_KO_Hnrnpu_SRP331236 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.00959 GSE195582_0_v_1_pim1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE173997_1_v_0_clic4_mouse RummaGEO Gene Perturbation Signatures -1.0 null FU97 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06035 GSE236437_0_v_3_aldosterone_human RummaGEO Drug Perturbation Signatures -1.0 null HCC364 CCLE Cell Line Gene Expression Profiles -1.0 -1.69413 H3K4me3_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null plastid-encoded plastid RNA polymerase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.354 Lingula (I), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.14114 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.294748 genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.407545 GSE207302,GSE207303_0_v_2_tp53bp2_human RummaGEO Gene Perturbation Signatures 1.0 null neurodevelopmental delay HPO Gene-Disease Associations 1.0 null SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K17546203 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71544 ATP-grasp fold InterPro Predicted Protein Domain Annotations 1.0 null HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.896032 layer 5 of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03053 YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RELA ENCODE Transcription Factor Targets 1.0 null GATA3-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null GSE157383_0_v_1_abemaciclib_human RummaGEO Drug Perturbation Signatures 1.0 null MC116 CCLE Cell Line Gene Expression Profiles 1.0 1.37227 S117 DepMap CRISPR Gene Dependency 1.0 2.08333 GSE213588_9_v_4_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE92364_0_v_5_asparaginase_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_2_GSC Rummagene Transcription Factor Associations 2026 1.0 null GTEX-P4QT-0526-SM-2I3EX GTEx Tissue Sample Gene Expression Profiles 1.0 1.38364 primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.95826 G124 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -3.01517 GTEX-S4UY-1626-SM-4AD55 GTEx Tissue Sample Gene Expression Profiles 1.0 1.39093 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19M-06A-61R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP4 ENCODE Transcription Factor Targets 1.0 null GTEX-W5X1-0001-SM-3P61V GTEx Tissue Sample Gene Expression Profiles 1.0 1.77356 SU-DHL-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.28353 Perturb_17185_OE_HER2_SRP166112 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -17.158 GSE192771_2_v_1_mt1g_human RummaGEO Gene Perturbation Signatures -1.0 null coralyne-6317 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MCF7_GSK J1_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137436 ZC3H7B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4411 POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4397-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_6089_KD_YBX3_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 3.0809 CAPAN-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.838195 MCF7_BMS-911543_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0134155 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54E-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null alpha-amino acid metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-POYW-0726-SM-2XCEO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.854331 496100362_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.35048 BRD-K51215422 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.02666 PMC8886057__F2 PFOCR Pathway Figure Associations 2024 1.0 null H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPIF_KO_GSE23028_45_mouse_heart (8 wk) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null RBM25 Pathway Commons Protein-Protein Interactions 1.0 null GSE209582_1_v_2_chloroquine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE232261,GSE232263_0_v_1_usf1_human RummaGEO Gene Perturbation Signatures -1.0 null IRF1 ChEA Transcription Factor Targets 1.0 null H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 8666_TAF5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.545838 GSE147876,GSE147877_4_v_11_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null mantle zone of m2AD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20399 K562_Quercetin_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0173528 Acute Myeloid Leukemia_LAML_TCGA-AB-2819-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EE-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_M344_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00726485 CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.955123 abnormal embryo size IMPC Knockout Mouse Phenotypes 1.0 null STAT1 ENCODE Transcription Factor Targets 1.0 null acids GeneRIF Biological Term Annotations 1.0 null GTEX-XQ3S-0006-SM-4BOQ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30838 1-EBIO LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73663 LSM12 Pathway Commons Protein-Protein Interactions 1.0 null YY1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SOX2-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GP5d Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.98963 PMC4590705-13062_2015_86_MOESM1_ESM.xlsx-Gene_A_-_TP53-Unnamed_16_TP53 Rummagene Transcription Factor Associations 2026 1.0 null hematopoietic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.404418 RPMI8226 DepMap CRISPR Gene Dependency 1.0 2.55022 NCI-H2023 COSMIC Cell Line Gene Mutation Profiles 1.0 null hippocampus (hippocampal formation)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0643 Nr1h2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.4537 mitochondrion LOCATE Predicted Protein Localization Annotations 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null fenofibrate_homo sapiens_gpl4044_gse15483 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null superficial stratum of r8BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28925 11823860-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null GSE144443_0_v_6_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null hematopoietic stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068146 GTEX-Q2AG-0526-SM-2S1PW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.906967 cerebellar cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.50244 Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6088-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3443-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZEB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Chemical And Drug Induced Liver Injury DisGeNET Gene-Disease Associations 1.0 null Primary somatosensory area, mouth, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13281 GTEX-RWSA-2026-SM-47JX8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.892629 Perturb_7010_KO_Trbp_SRP056963 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.80253 GSE210655_1_v_0_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE147283_1_v_3_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of the VAP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18996 GSE147876,GSE147877_4_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-18-3408-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JW-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.16535 H3K79me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null rt4 HPA Cell Line Gene Expression Profiles 1.0 0.962895 GSE130217_5_v_3_sesn2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE229973_4_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE181959_1_v_2_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null Mitochondrion COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 IKZF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K06355852 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69407 NFIX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.6987 Perturb_7783_KD_BS691_SRP030639 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 YY1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null 19036130-TableS1a GeneSigDB Published Gene Signatures 1.0 null H3K27ac_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RM2N-1726-SM-2TF55 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10458 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNRNPU Pathway Commons Protein-Protein Interactions 1.0 null NCBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16388 HSPA1B Pathway Commons Protein-Protein Interactions 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2987-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE48812_11_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-RU1J-0126-SM-2TF6Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.41904 RPL18A Pathway Commons Protein-Protein Interactions 1.0 null NHERF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17617 Skeletal muscle TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K14875480 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.491 BRD-K93774122 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.47098 BRD-K07697589 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09584 H3K4me1_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Mobilized_CD34_Primary_Cells_Female Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.11425 6024_PABPC1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.785008 5548_NDUFAF5_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.74602 ETS1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K34737616 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60374 BRD-K39159284 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5259 periventricular stratum of r2BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.78843 CoA carboxylase activity GO Molecular Function Annotations 2023 1.0 null H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN011_HEPG2_24H:F10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2965 Drug-Induced Liver Disease DisGeNET Gene-Phenotype Associations 1.0 null POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Huntington's Disease_CNS - Brain (MMHCC)_GSE857 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.6031 ELK1::HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3777 H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Mitochondrion CM4AI U2OS Cell Map Protein Localization Assemblies 1.0 null Perturb_15535_KD_Ash1l_SRP366889 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 17.8794 branched-chain amino acid metabolic process GO Biological Process Annotations 2023 1.0 null PMC6441895-MOL2-13-959-s002.xlsx-Table_S4-Supplementary_Table_S4_Suvival_analysis_of_the_potential_ZBRK1_transcriptial_repressed_metabolic_genes_by_BreastMark_database_ZNF350 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K10089296 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.709 H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-S3XE-0526-SM-4AD4G GTEx Tissue Sample Gene Expression Profiles 1.0 0.938456 K562_Aurora A Inhibitor I_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0143644 GSE228181_4_v_5_idh1_mouse RummaGEO Gene Perturbation Signatures -1.0 null K562_Linifanib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159266 BRD-K48922193 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.591 A-Netherlands-602-2009(H1N1)_24Hour_None_GSE40844 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.338 CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.68059 H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TEAD4_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r10 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10162 PMC8755441-mmc3.xlsx-IRF1-UP-mono_IRF1 Rummagene Transcription Factor Associations 2026 1.0 null SPI1 ChEA Transcription Factor Targets 1.0 null GTEX-PWOO-2326-SM-2S1PQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.935698 OLIG2-29049317-MOUSE-SPINALCORD ChEA Transcription Factor Targets 2022 1.0 null Mhs TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.587 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.088 Skin Cutaneous Melanoma_SKCM_TCGA-D9-A6EC-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OVKATE CCLE Cell Line Gene CNV Profiles 1.0 1.69491 striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.50179 569_ASB8_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.574844 MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09207 BRD-K94442101 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63134 GSE220520_6_v_9_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null EA-39-YN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.321154 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null superficial stratum of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.74976 vertebrate muscular system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.39 Organic acidemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.283 MAFF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8365 MCF7_KW-2449_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142152 ACTB Pathway Commons Protein-Protein Interactions 1.0 null GTEX-Q734-0006-SM-2I3FJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14783 GSE88819_6_v_12_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CUX1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6469946-aav1472_Data_file_S3.xlsx-PPARG_targets_UP_RNA-Seq_Diet-Supplemental_Table_3_PPARG_targets_up_regulated_in_dKO_vs_CONTROL_RNA-Seq_Diet_FDR_0_1_n_290_PPARG Rummagene Transcription Factor Associations 2026 1.0 null USF2_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE147876,GSE147877_2_v_8_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WI4N-0726-SM-3TW93 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.889994 spinal (inferior) vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.886383 BRD-K36662285 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12496 abnormality of metabolism/homeostasis HPO Gene-Disease Associations 1.0 null MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043703 GSE77108_8_v_2_saha_human RummaGEO Drug Perturbation Signatures -1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDC42 Pathway Commons Protein-Protein Interactions 1.0 null GABPA ENCODE Transcription Factor Targets 1.0 null dipyrocetyl LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80561 20460542-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCCC2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00553627 GSE126762_1_v_0_klf15_mouse RummaGEO Gene Perturbation Signatures -1.0 null PITX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6322 K562_Mercaptopurine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154933 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZEB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Seh1-associated complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.813 Epididymis TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE213588_8_v_5_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17898 hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.37324 cellular catabolic process GO Biological Process Annotations 2015 1.0 null GTEX-S4UY-0926-SM-4AD6O GTEx Tissue Sample Gene Expression Profiles 1.0 1.49143 MAX_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_ASH2L_23239880 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Metabolism Reactome Pathways 2024 1.0 null TAF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_1_GSC Rummagene Transcription Factor Associations 2026 1.0 null LIVF001-023 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52375 posterior tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45809 HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE220520_3_v_8_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null GM97 BioGPS Cell Line Gene Expression Profiles -1.0 -1.83478 H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BCL11A ENCODE Transcription Factor Targets 1.0 null GTEX-QMRM-0826-SM-3NB33 GTEx Tissue Sample Gene Expression Profiles 1.0 0.921812 visual cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.430695 GSE154253_1_v_0_tnfaip8_human RummaGEO Gene Perturbation Signatures 1.0 null Metabolism of amino acids and derivatives Reactome Pathways 2024 1.0 null branched-chain amino acid catabolic process GO Biological Process Annotations 2015 1.0 null Metabolism of amino acids and derivatives Reactome Pathways 2014 1.0 null EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.75746 GSE202434,GSE202438_2_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null nucleus incertus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.48081 amygdaloid complex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.27956 GSE148692,GSE148695_2_v_6_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WYVS-0006-SM-3NMA7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.97719 SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE239844_7_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041219 IRF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null methylcrotonoyl-CoA carboxylase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 3.29 GTEX-T5JW-0003-SM-3NMAD GTEx Tissue Sample Gene Expression Profiles 1.0 0.878427 inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.897872 than GeneRIF Biological Term Annotations 1.0 null MOV10 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K69790201 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51021 RPL12 Pathway Commons Protein-Protein Interactions 1.0 null GSE124410_2_v_4_stk40_mouse RummaGEO Gene Perturbation Signatures 1.0 null ATF2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Sorafenib Tosylate_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0166641 GSE226584,GSE226589_2_v_0_ezh2_human RummaGEO Gene Perturbation Signatures -1.0 null CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBX2-33478486-IMR90-HUMAN-LUNG ChEA Transcription Factor Targets 2022 1.0 null adult TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.520041 Ventral anterior nucleus of thalamus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.347 BRD-K77273085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04034 cardiovascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059589 K562_Lapatinib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145487 PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S13-Table_S13_MR_resluts_of_brain_pQTL_and_large-artery_atherosclerotic_stroke_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null CCK81 DepMap CRISPR Gene Dependency 1.0 3.6972 HIST2H2AC Pathway Commons Protein-Protein Interactions 1.0 null Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.763 GTEX-QDVN-0226-SM-48TZ9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.872813 IRAK2_knockout_76_GSE24264 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.72803 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WK11-0006-SM-3NB3J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06575 MCF7_FLLL32_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152635 superficial stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17018 GSE241875_1_v_0_huwe1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K36713925 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15989 AN3 CA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null USF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal raphe nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.40669 POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33622 H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75654 Synucleinopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.979 HIST1H2AJ Pathway Commons Protein-Protein Interactions 1.0 null REST ENCODE Transcription Factor Targets 1.0 null liver_d HPA Tissue Sample Gene Expression Profiles 1.0 0.986105 GTEX-XUJ4-0004-SM-4BOQE GTEx Tissue Sample Gene Expression Profiles 1.0 0.991148 BRD-K99827210 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07581 GSE182680,GSE182683_7_v_2_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null UBC Pathway Commons Protein-Protein Interactions 1.0 null GTEX-Q2AH-2026-SM-2S1PX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.911822 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null GSE111035,GSE111040_10_v_9_plag1_mouse RummaGEO Gene Perturbation Signatures -1.0 null intracellular organelle lumen COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HIST1H2BJ Pathway Commons Protein-Protein Interactions 1.0 null KYSE-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27765 essential tremor DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.638676 layer III of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.19234 GSE211215_1_v_0_pemetrexed_human RummaGEO Drug Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-VM-A8CD-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null estradiol_homo sapiens_gpl96_gse4668 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null K562_MK-5108_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160785 seizures HPO Gene-Disease Associations 1.0 null Anterior cingulate cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.882 SMARCC1 ENCODE Transcription Factor Targets 1.0 null lymph node HPA Tissue Protein Expression Profiles -1.0 -0.863794 BRD-K60188481 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.35789 A549_Roxadustat_10然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0124219 posterodorsal tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.04656 GTEX-WCDI-0005-SM-3NB2M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11239 EC-GI-10 GDSC Cell Line Gene Expression Profiles -1.0 -1.64391 K562_Aminoglutethimide_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145332 GTEX-S4Z8-0526-SM-4AD4T GTEx Tissue Sample Gene Expression Profiles 1.0 1.17736 BRD-K88613983 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25585 Disease Reactome Pathways 2024 1.0 null GSE135352_0_v_4_napabucasin_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K13389917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51248 GTEX-OXRK-0126-SM-3NB1E GTEx Tissue Sample Gene Expression Profiles 1.0 3.15521 Necrosis CTD Gene-Disease Associations 1.0 1.91569 PMC3805607__F2 PFOCR Pathway Figure Associations 2023 1.0 null VIM Pathway Commons Protein-Protein Interactions 1.0 null BRD-K64860662 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.10963 MCF7_Veliparib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0182121 MAFF ENCODE Transcription Factor Targets 1.0 null H3K27ac_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null r8 part of lateral reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34611 posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.29853 GSE129153_0_v_1_forskolin_human RummaGEO Drug Perturbation Signatures 1.0 null K562_Veliparib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160412 Brain ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null adult stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062014 Acute Hepatic Steatosis DisGeNET Gene-Disease Associations 1.0 null parkinson's disease GAD Gene-Disease Associations 1.0 null BRD-K38932508 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2655 K562_Tie2 kinase inhibitor_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0228238 Diabetic Neuropathy_Sciatic Nerve_GSE11343 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.44337 RNASE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07636 HCC12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.46817 H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T2IS-0426-SM-32QPE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.966985 kidney cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.076471 Anaplasmosis_Leukemic Cell_GSE2600 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -0.917119 small molecule catabolic process GO Biological Process Annotations 2015 1.0 null intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.25547 decreased total retina thickness MGI Mouse Phenotype Associations 2023 1.0 null CRCGN011_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.54025 MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7103-01A-21R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.744766 H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XB-01A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 16467079-Table3b GeneSigDB Published Gene Signatures 1.0 null FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.350926 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table3_WBBC_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null GSE87412,GSE92423_0_v_4_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.178 BRD-K47951859 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46784 organic acidemia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.6077 GSE111247_2_v_8_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null VIIAf Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.73816 CTCF_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNRPB Pathway Commons Protein-Protein Interactions 1.0 null KLF15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29851 Anemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.098 mutagenesis GeneRIF Biological Term Annotations 1.0 null Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 smoothmuscle_8c HPA Tissue Sample Gene Expression Profiles -1.0 -0.830389 A549 CCLE Cell Line Gene CNV Profiles -1.0 -1.35605 A549_Ofloxacin_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0108418 POTEE Pathway Commons Protein-Protein Interactions 1.0 null CAOV3 CCLE Cell Line Gene CNV Profiles 1.0 1.6655 urinary bladder HPA Tissue Gene Expression Profiles 1.0 1.05018 GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles -1.0 -2.0295 BRD-K22390389 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11801 TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE180200,GSE180201_5_v_6_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null abnormality of nervous system physiology GWASdb SNP-Phenotype Associations 1.0 0.159124 primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.11412 USF2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Tofacitinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0142748 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A4-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K07526417 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09719 KDM4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55055 H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null outer CP in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.87961 JUN_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_HEPG2_48H:B19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.48143 requirements GeneRIF Biological Term Annotations 1.0 null GSE123943_1_v_3_sox1_human RummaGEO Gene Perturbation Signatures 1.0 null 5205_MRPL21_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.11238 ligase activity, forming carbon-nitrogen bonds GO Molecular Function Annotations 2015 1.0 null HIST3H2A Pathway Commons Protein-Protein Interactions 1.0 null HIPK2_knockout_171_GSE39253 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 0.789099 STAT5A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KRT10 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5458-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Malaria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.546 Mitochondrial electron transfer flavoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.725 GSE137653_4_v_0_siglecf_mouse RummaGEO Gene Perturbation Signatures -1.0 null SP1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA3 ENCODE Transcription Factor Targets 1.0 null GNA15 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00410298 GSE229973_3_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17338 H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null E2F4 ENCODE Transcription Factor Targets 1.0 null H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE220520_1_v_7_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FAM204A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40612 HIST3H3 Pathway Commons Protein-Protein Interactions 1.0 null EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4LF-0526-SM-3NMB6 GTEx Tissue Sample Gene Expression Profiles 1.0 2.44314 abdominal symptom HPO Gene-Disease Associations 1.0 null Uterus GTEx Tissue Gene Expression Profiles 2023 1.0 0.775528 r7 part of nucleus prepositus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38483 GSE160246_9_v_7_cpeb4_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Disease of anatomical entity DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 5.0 BRD-K78747341 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.29343 ventrolateral prefrontal cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.896928 nes HPA Cell Line Gene Expression Profiles -1.0 -1.41649 dorsolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.4341 r7 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01942 ventrolateral part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02235 GBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.5807 MCF7_Panobinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0160675 XC-81-LR46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.273697 abnormality of body weight HPO Gene-Disease Associations 1.0 null BRD-K89863047 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13185 STAU1 Pathway Commons Protein-Protein Interactions 1.0 null intermediate stratum of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07544 NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.986392 GSE180147_0_v_1_itga5_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K70274124 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28492 CTCF_fibroblast of foreskin _hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28059 GSE111247_11_v_10_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE239844_11_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null Late onset Parkinson's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.344 HSPD1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Ezh2_Deficiency_GDS4309_364_mouse_Hearts GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.840261 Lateral reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4009 H3K9ac_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 2796_EXOSC9_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.584342 REST_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K94580036_-666_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 3-methylcrotonyl-coa carboxylase deficiency DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null TAF1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5518-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ANXA2 Pathway Commons Protein-Protein Interactions 1.0 null Rectum adenocarcinoma_READ_TCGA-EI-6884-01A-11R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XGQ4-1026-SM-4AT4L GTEx Tissue Sample Gene Expression Profiles 1.0 0.977872 eGFP-FOS_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mitochondrial membrane GO Cellular Component Annotations 2015 1.0 null GSE243683_0_v_1_s100a16_mouse RummaGEO Gene Perturbation Signatures -1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JV-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE121824,GSE121826_0_v_2_scaf8_human RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K10189430 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21739 CRCGN016_MCF10A.TP53.M_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.85226 trophozoite TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.314409 organonitrogen compound catabolic process GO Biological Process Annotations 2015 1.0 null membrane GO Cellular Component Annotations 2015 1.0 null Perturb_17180_OE_HER2_SRP166112 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -9.67668 abnormality of central motor function GWASdb SNP-Phenotype Associations 1.0 1.40061 Parkinson Disease DisGeNET Gene-Disease Associations 1.0 null TCF3 ENCODE Transcription Factor Targets 1.0 null SHARPIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41154 GSE213588_9_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null SP1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XGQ4-0008-SM-4AT3Z GTEx Tissue Sample Gene Expression Profiles -1.0 -0.888435 vitamin metabolic process GO Biological Process Annotations 2015 1.0 null GSE155162,GSE155169_1_v_3_buparlisib_human RummaGEO Drug Perturbation Signatures -1.0 null TCF4-23295773-U87-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:A20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1041 POLR2A_GM10847_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null dorsolateral prefrontal cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.97709 A-VN-1203-2004(H5N1)_Day1-10^2pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.68296 GTEX-WFG8-0006-SM-3GIKS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14932 LUDLU1 CCLE Cell Line Gene CNV Profiles 1.0 1.36788 GSE98831_1_v_0_brca1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K82292504 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38654 Lung function (FVC) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.522185 POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease Progression HuGE Navigator Gene-Phenotype Associations 1.0 null GTEX-XPVG-2726-SM-4B66W GTEx Tissue Sample Gene Expression Profiles 1.0 0.917051 GSE221327_5_v_9_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null reduced consciousness/confusion HPO Gene-Disease Associations 1.0 null SCABER DepMap CRISPR Gene Dependency 1.0 3.53256 schizont TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.692085 DAZAP1 Pathway Commons Protein-Protein Interactions 1.0 null medial mammillary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15067 CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ABC1 CCLE Cell Line Gene Expression Profiles 1.0 2.32321 BICR 22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.06653 Myocardial Infarction_Myocardial tissue_GSE4105 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.61751 BRD-K31218318 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22067 CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Exocytic vesicle membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.603 GTEX-PLZ4-0006-SM-2S1NY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08908 skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.62464 BRD-K93508241 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.98662 GFER CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29569 Homodimeric serine palmitoyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.481 GSE136232,GSE136234_0_v_1_zpbp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ventral part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58798 Adrenocortical carcinoma_ACC_TCGA-OR-A5J2-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null parvocellular part of the r9LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.15965 ZNF274 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.541 BACH1 ENCODE Transcription Factor Targets 1.0 null Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Reactome Pathways 2014 1.0 null MKI67 Pathway Commons Protein-Protein Interactions 1.0 null strychnine-hcl LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06298 H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Multiple carboxylase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.995 Artery TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE245390_2_v_1_acss2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Urea cycle disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.661 POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.65219 GTEX-P4PP-0326-SM-33HC4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.91955 RFX5 ENCODE Transcription Factor Targets 1.0 null molecular_function GO Molecular Function Annotations 2015 1.0 null GTEX-R53T-0226-SM-48FEH GTEx Tissue Sample Gene Expression Profiles 1.0 1.16659 H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null caudal ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17807 GTEX-X4XX-0005-SM-3NMCS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30601 KYSE-450 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-XYKS-0926-SM-4BRVG GTEx Tissue Sample Gene Expression Profiles 1.0 0.919021 NCI-H1836 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.33449 carboplatin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26852 E2F6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL17 Pathway Commons Protein-Protein Interactions 1.0 null CCNT2 ENCODE Transcription Factor Targets 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A76B-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A116-11A-12R-A26B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null coma HPO Gene-Disease Associations 1.0 null ATP-binding cassette (ABC) transporter complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.755 MFE-280 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 Biotin carboxylase, C-terminal InterPro Predicted Protein Domain Annotations 1.0 null Biotin/lipoyl attachment InterPro Predicted Protein Domain Annotations 1.0 null GSE210580_4_v_1_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Atrium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.705 GSE227592_4_v_3_adar_human RummaGEO Gene Perturbation Signatures 1.0 null Atrophy CTD Gene-Disease Associations 1.0 1.04684 GSE220520_6_v_2_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null MCF7_AICAR_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.017615 BRD-K74881104 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17347 disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.557897 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Genetic disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 5.0 BRD-K28916077_-666_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-TKQ2-0004-SM-3NMAC GTEx Tissue Sample Gene Expression Profiles 1.0 1.28075 GSE195663_7_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K15800236 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27075 BRD-K68336408_Tyrphostin AG 1478_SNUC4_6.0_h_56.78_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE180200,GSE180201_5_v_11_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CUX1 ENCODE Transcription Factor Targets 1.0 null GSE215086_5_v_0_batf_human RummaGEO Gene Perturbation Signatures 1.0 null K562_TMP195_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159664 BICR22 CCLE Cell Line Gene CNV Profiles 1.0 2.2311 18387200-Genes GeneSigDB Published Gene Signatures 1.0 null SIRT6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-A4BX-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_BMS-536924_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0173405 Caov-4 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.62084 GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824945 CAKI-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.62946 CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null KRT81 Pathway Commons Protein-Protein Interactions 1.0 null Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.061 CTCF_fibroblast of mammary gland_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K90475322 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36518 mucinous cystadenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.865502 GSE221577_3_v_5_pik3r1_human RummaGEO Gene Perturbation Signatures 1.0 null MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE244072_4_v_1_tfeb_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5982-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 fat_x1.V2 HPA Tissue Sample Gene Expression Profiles 1.0 1.3444 BRD-A34842997 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37888 SYK_druginhibition_290_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.84707 H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null GSE227698_5_v_4_g0s2_human RummaGEO Gene Perturbation Signatures -1.0 null PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF Rummagene Transcription Factor Associations 2026 1.0 null CRCGN013_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.08286 BRD-K24039194 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07228 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 RPS18 Pathway Commons Protein-Protein Interactions 1.0 null intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R4-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-HS-A5N8-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.860211 GSE148066,GSE157787_2_v_1_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ADP MW Enzyme Metabolite Associations 1.0 null GSE158632_2_v_5_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-A4BY-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.87173 SNRNP70 Pathway Commons Protein-Protein Interactions 1.0 null Oligospermia CTD Gene-Disease Associations 1.0 1.30696 small molecule metabolic process GO Biological Process Annotations 2015 1.0 null primary auditory cortex (core)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.870634 H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Retrosplenial area, lateral agranular part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46724 SPI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Essential tremor DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.034 GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.96216 CRCGN009_HEPG2_24H:H04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.33299 GSE226114,GSE226116_1_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Maple syrup urine disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.775 8662_TAF2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.51178 hsa-miR-4272 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.407919 9686_UTP3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.568509 RERFLCSQ1 CCLE Cell Line Gene CNV Profiles 1.0 2.32785 MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K12043227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.99723 aa94 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.547 BRD-K08899466 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22933 GSE105406_0_v_3_ptcd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS3 Pathway Commons Protein-Protein Interactions 1.0 null KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Corticospinal tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.528 VZ in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20355 GSE198165,GSE198166_6_v_11_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null Atf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.5957 CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Synaptic vesicle membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.606 H3K79me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 2.15873 BRD-K36282114 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09194 CRCGN015_HEPG2_48H:A08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.49694 NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04938 purine nucleoside binding GO Molecular Function Annotations 2015 1.0 null ETS1 ENCODE Transcription Factor Targets 1.0 null TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.53662 brain disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.682635 H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE130383_2_v_0_gps2_mouse RummaGEO Gene Perturbation Signatures 1.0 null TMPO Pathway Commons Protein-Protein Interactions 1.0 null demonstrates GeneRIF Biological Term Annotations 1.0 null TUBB Pathway Commons Protein-Protein Interactions 1.0 null Perturb_17193_OE_ESR1_SRP166112 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE166184,GSE166185_1_v_0_sox2_human RummaGEO Gene Perturbation Signatures -1.0 null upper (rostral) rhombic lip_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.6339 Skeletal system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K27ac_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE203362_0_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 SW1463 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.0518 T47D Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.57801 BRD-K91469267 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33186 abnormality of carbohydrate metabolism/homeostasis HPO Gene-Disease Associations 1.0 null K562_Lapatinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.016796 EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYB-26560356-CHIP-SEQ-TH1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K87399364 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3054 GSE169152_5_v_4_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN Rummagene Transcription Factor Associations 2026 1.0 null superficial stratum of r2BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12321 Posterior parietal association areas, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44482 RT4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.36998 GSE198165,GSE198166_6_v_3_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null VMRCLCP CCLE Cell Line Gene CNV Profiles 1.0 1.81918 superficial stratum of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21011 MCF7_Tie2 kinase inhibitor_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0105858 H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE190186,GSE190188_0_v_10_apoe_mouse RummaGEO Gene Perturbation Signatures 1.0 null PTX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89967 cerebellar cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.01847 CRCGN015_HEPG2_48H:A14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.87163 MCF7_PCI-34051_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0173497 Brain Lower Grade Glioma_LGG_TCGA-CS-6667-01A-12R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POU2F2 ENCODE Transcription Factor Targets 1.0 null tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 motor cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.459532 Very long chain acyl-CoA dehydrogenase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.75 OSC-20 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null T-47D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.63882 GTEX-S4Q7-0006-SM-3K2AT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45161 GTEX-RU72-0006-SM-2TF65 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20608 periventricular mantle of isBM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10915 r9 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40817 RC-K8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.842952 REST_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null artery TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CTCF_fibroblast of skin of abdomen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferior olive, dorsal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.27702 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null lateral posterior nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22949 MZ in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.941249 Perturb_8012_KD_Ddx3_SRP324914 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 8.34366 Parietal lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.369 connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.508242 GTEX-OIZF-0006-SM-2I5GQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01412 MCF7_Quisinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0108015 GSE87412,GSE92423_0_v_1_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null RPS12 Pathway Commons Protein-Protein Interactions 1.0 null DSH1 GDSC Cell Line Gene Expression Profiles 1.0 1.87954 TE-10 GDSC Cell Line Gene Expression Profiles 1.0 2.35704 loci GeneRIF Biological Term Annotations 1.0 null Neural Tube Defects CTD Gene-Disease Associations 1.0 1.03789 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null terminal subparaventricular area of THyA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09589 CRCGN015_HEPG2_48H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.31771 Basomedial amygdalar nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.534 MCC13 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K24727463 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03319 H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC2814 CCLE Cell Line Gene CNV Profiles 1.0 2.06046 lethargy HPO Gene-Disease Associations 1.0 null BATF ENCODE Transcription Factor Targets 1.0 null mantle zone of r1BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06253 MAX_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE221327_6_v_9_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A.TP53.M_24H:D20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.42275 ChIP_SOX17_20123909 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null phenotypic variability HPO Gene-Disease Associations 1.0 null BRD-K72335238 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25562 MCF7_Givinostat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0130561 CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRPM7_defectivemutant_306_GSE23102 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.54424 NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54829 GSE125862_2_v_0_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.829806 GSE48812_3_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null Cingulate gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.341 GSE149901_2_v_0_anlotinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 4108_IMP4_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.531416 GSE214931_2_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE229973_3_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Hypoglycemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.07 t47d HPA Cell Line Gene Expression Profiles 1.0 2.57389 CTCF_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null revealed GeneRIF Biological Term Annotations 1.0 null MCF7_Mercaptopurine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0196782 imatinib_homo sapiens_gpl96_gds3044 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.78451 BRD-K96981233 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09732 JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.3703 abnormality of the abdomen HPO Gene-Disease Associations 1.0 null lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17024 TCF12_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052196 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null OCI-AML2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.54648 mantle zone of TSPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0967 PMC12069319-Table1.xlsx-OCAB_p35_BirA-Gene_Symbol_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Carbamoyl-phosphate synthase, large subunit, N-terminal InterPro Predicted Protein Domain Annotations 1.0 null ventrolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.883025 TAF1_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE264010_0_v_1_parp1_human RummaGEO Gene Perturbation Signatures 1.0 null RPS19 Pathway Commons Protein-Protein Interactions 1.0 null NR3C1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.8044 H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC8033524-EMMM-13-e13162-s004.xlsx-d_GREAT_on_NFIB_bound-genes_HF-Unnamed_0_NFIB Rummagene Transcription Factor Associations 2026 1.0 null GSE48812_7_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null SNRPC Pathway Commons Protein-Protein Interactions 1.0 null squamous epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058903 MFE319 DepMap CRISPR Gene Dependency 1.0 2.49827 Liver Cirrhosis CTD Gene-Disease Associations 1.0 1.09154 FOSL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-O5YT-1026-SM-3MJGF GTEx Tissue Sample Gene Expression Profiles 1.0 0.90169 aciduria HPO Gene-Disease Associations 1.0 null GSE237040_2_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null TBP ENCODE Transcription Factor Targets 1.0 null placenta_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.43674 CRCGN015_HEPG2_48H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2181 Lung adenocarcinoma_LUAD_TCGA-67-3770-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7525_RPS3_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.507481 superior colliculus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.38682 18757322-TableS3 GeneSigDB Published Gene Signatures 1.0 null PHA granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.519 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE149124,GSE149128_3_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE229973_3_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletal system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null single-organism process GO Biological Process Annotations 2015 1.0 null RPS14 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K08715020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38848 GTEX-V955-0004-SM-3NMDH GTEx Tissue Sample Gene Expression Profiles 1.0 1.41205 mantle zone of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25301 MC116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.842952 A549_SRT3025 HCl_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0150264 superficial part of arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62379 GSE239844_6_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null MCM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21978 POLR2A ENCODE Transcription Factor Targets 1.0 null SOCS3_KO_GDS3149_8_mouse_multiple cell types GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null metabolic acidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.211261 POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.82073 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UN-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE213588_10_v_7_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null carboxylic acid binding GO Molecular Function Annotations 2015 1.0 null GSE157555,GSE157556_4_v_2_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.893583 GTEX-UTHO-1826-SM-3GAFE GTEx Tissue Sample Gene Expression Profiles 1.0 0.90931 GSE242367_1_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE152055_2_v_1_mpc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null cranial nerve disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.068349 GTEX-V955-0126-SM-4JBH5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20323 POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null superficial stratum of r5BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07256 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Adrenocortical carcinoma_ACC_TCGA-OR-A5JL-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.72635 GSE161825_1_v_0_tipranavir_human RummaGEO Drug Perturbation Signatures 1.0 null dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.53329 H2BK120ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMK1-0226-SM-4B65D GTEx Tissue Sample Gene Expression Profiles 1.0 1.75291 BRD4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00577872 AN3 CA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.87654 GTEX-X8HC-2826-SM-46MWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.94862 Rosette TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.228 GSE153757,GSE153758_1_v_3_ftsj1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Liver TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Parkinson's disease or first degree relation to individual with Parkinson's disease GWAS Catalog SNP-Phenotype Associations 2025 1.0 3.4 myeloid leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.09135 PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE163862_2_v_3_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null cerebral lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.076466 USP15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51671 8666_TAF5_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.688091 HCFC2 Pathway Commons Protein-Protein Interactions 1.0 null NCI-H2369 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.898114 GSE172020_0_v_3_testosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null Glucose Intolerance CTD Gene-Disease Associations 1.0 1.44382 SIN3A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K85802892 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.85557 GSE107505_1_v_2_nanog_mouse RummaGEO Gene Perturbation Signatures 1.0 null myoblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.145611 GATA4-21415370-HL-1-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26659 KDM5B ENCODE Transcription Factor Targets 1.0 null GSE172019_2_v_8_rnf2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUZC-0226-SM-4BOO7 GTEx Tissue Sample Gene Expression Profiles 1.0 2.24701 Cell Transformation, Neoplastic CTD Gene-Disease Associations 1.0 1.80887 GTEX-QESD-0626-SM-2I5G4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827633 GSE197850_4_v_3_glucagon_human RummaGEO Drug Perturbation Signatures -1.0 null HCT 116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.51046 retropontine reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21522 HOXB4-20404135-EML-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL18 Pathway Commons Protein-Protein Interactions 1.0 null PMC10165825-13046_2023_2674_MOESM1_ESM.xlsx-Supplementary_Table_S7-Supplementary_Table_S7_Differential_expression_results_for_the_TEAD-TP63_directly_regulated_genes_TP63 Rummagene Transcription Factor Associations 2026 1.0 null CAKI1 DepMap CRISPR Gene Dependency 1.0 9.65429 9073_TMEM41B_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.591742 GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.970707 SUMO2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-UPK5-0008-SM-4IHJD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.898232 PMC3919568__F7 PFOCR Pathway Figure Associations 2023 1.0 null superior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.838838 primary motor cortex (area M1, area 4)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.52502 PMC5732738-oncotarget-08-103415-s002.xlsx-CAMA1_DEGs-Genes_differentially_expressed_by_1_25_fold_between_parental_CAMA1_cells_and_GATA3_mutant_knock-in_clone_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null GSE226249_0_v_4_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null RPL11 Pathway Commons Protein-Protein Interactions 1.0 null necessary GeneRIF Biological Term Annotations 1.0 null vomiting HPO Gene-Disease Associations 1.0 null causing GeneRIF Biological Term Annotations 1.0 null GTEX-UPK5-0003-SM-3NMDI GTEx Tissue Sample Gene Expression Profiles 1.0 0.949617 GTEX-SUCS-1826-SM-32PM1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.55386 periventricular stratum of r6BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37972 CRCGN010_HEPG2_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.08522 cerebellum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.34023 A549_ABT-737_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.014008 GSE88819_1_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Alzheimer Disease DisGeNET Gene-Disease Associations 1.0 null Breast Neoplasms CTD Gene-Disease Associations 1.0 1.33257 MCCC2 NURSA Protein-Protein Interactions 1.0 0.355524 GSE208096_1_v_0_progesterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null K562_S3I-201_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0183371 ventrolateral periolivary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62737 Peroxisomal matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.604 Sporadic Parkinson Disease DisGeNET Gene-Disease Associations 1.0 null TCF12 ENCODE Transcription Factor Targets 1.0 null BRD-K26217579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85 PSD4 Pathway Commons Protein-Protein Interactions 1.0 null abnormality of higher mental function HPO Gene-Disease Associations 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.85 GTEX-OXRK-0826-SM-2HMK7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.921095 intracellular organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 FOXM1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r6 part of the cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88268 CALM1 Pathway Commons Protein-Protein Interactions 1.0 null GSE168097_3_v_2_epinephrine_human RummaGEO Drug Perturbation Signatures -1.0 null KYSE-180 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 HSPA9 Pathway Commons Protein-Protein Interactions 1.0 null Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.557 PMC11531655-MCO2-5-e754-s001.docx-0-IRF7_Regulon_4_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null MAFK_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.347967 GSE88819_11_v_12_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.832076 GTEX-VJWN-0005-SM-3GIKF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18697 membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r8 part of inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.08207 BRD-A37105798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1984 GTEX-R53T-0926-SM-3GADH GTEx Tissue Sample Gene Expression Profiles 1.0 1.21349 lateral superior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44056 MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K24950073 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50027 Perturb_1016_KO_Nt5e_SRP404924 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.72252 Perturb_7330_KO_CD34_SRP156691 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.73865 Lung squamous cell carcinoma_LUSC_TCGA-43-3394-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null heart_5a HPA Tissue Sample Gene Expression Profiles 1.0 0.933798 Perturb_17178_OE_HER2_SRP166112 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -15.8791 cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 cellular nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null korean GeneRIF Biological Term Annotations 1.0 null UACC893 DepMap CRISPR Gene Dependency 1.0 2.854 GSE196104,GSE196106_3_v_1_vsx2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WEY5-0426-SM-3GIKT GTEx Tissue Sample Gene Expression Profiles 1.0 0.904811 WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A634-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DAUDI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09395 GSE186810,GSE186813_7_v_0_furin_mouse RummaGEO Drug Perturbation Signatures 1.0 null abnormality of nervous system morphology HPO Gene-Disease Associations 1.0 null PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table7_gnomAD_AMR_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-SNMC-1326-SM-2XCFK GTEx Tissue Sample Gene Expression Profiles 1.0 1.70233 GSE210476_2_v_6_rutaecarpine_human RummaGEO Drug Perturbation Signatures 1.0 null Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Nr1h4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.5285 cytoplasmic part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NM-01A-21R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBM7 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDAMB175VII Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.964102 MCM5 Pathway Commons Protein-Protein Interactions 1.0 null SuperiorCervicalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.890605 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5706-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H441 GDSC Cell Line Gene Expression Profiles 1.0 1.45114 beta-ketothiolase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.465 GTEX-SE5C-0726-SM-4BRWY GTEx Tissue Sample Gene Expression Profiles 1.0 0.835424 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4864-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lymphocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.367 Valine, leucine and isoleucine degradation KEGG Pathways 2026 1.0 null dorsal thalamus_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.92721 EBF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.49847 CRCGN012_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.29024 RPS15A Pathway Commons Protein-Protein Interactions 1.0 null urinarybladder_5c HPA Tissue Sample Gene Expression Profiles 1.0 1.89183 abnormality of higher mental function GWASdb SNP-Phenotype Associations 1.0 0.272266 KNS-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.60968 H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Memory Disorders CTD Gene-Disease Associations 1.0 1.25745 PMC9010637-mmc6.xlsx-5D-Figure_5D_Gene_Expression_Zhou_et_al_Application_of_SP3-Rox_to_identify_redox_changes_during_T_cell_maturation_SP3 Rummagene Transcription Factor Associations 2026 1.0 null PMC8017594-LSA-2019-00332_Table_S1_Table_12.xls-DCX-KD_LIS1-KD_DEGs-LIS1-KD_AR Rummagene Transcription Factor Associations 2026 1.0 null NCI-H1155 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.20942 H3K4me1_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE88819_6_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Biotin carboxylase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.934 GSE147876,GSE147877_2_v_7_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1 Rummagene Transcription Factor Associations 2026 1.0 null PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_16_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XPT6-0001-SM-4B64G GTEx Tissue Sample Gene Expression Profiles 1.0 1.05587 striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.57887 point GeneRIF Biological Term Annotations 1.0 null pretectal region Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.968648 IFIT1B Pathway Commons Protein-Protein Interactions 1.0 null Global Developmental Delay DisGeNET Gene-Disease Associations 1.0 null MYC_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null KPL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.61398 organelle part GO Cellular Component Annotations 2015 1.0 null breast HPA Tissue Protein Expression Profiles -1.0 -1.03303 H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null adenyl nucleotide binding GO Molecular Function Annotations 2015 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2917-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE147240_3_v_6_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA1-26457646-LHSAR-HUMAN-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null GTEX-OXRN-0005-SM-2I5EU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33944 AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63U-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE217776,GSE217829_4_v_6_sgf29_human RummaGEO Gene Perturbation Signatures -1.0 null HSF1_KD_GDS1733_755_human_HeLa cells - 0.5 Hour by siHSF1_2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Nervous System Malformations CTD Gene-Disease Associations 1.0 1.23837 GSE128232,GSE128233_1_v_0_phf2_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K77899084 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41864 GSE226115,GSE226116_2_v_0_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null Musculoskeletal system disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 5.0 H3K27ac_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AN-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF221 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02253 causative GeneRIF Biological Term Annotations 1.0 null abnormality of blood glucose concentration HPO Gene-Disease Associations 1.0 null CHD2 ENCODE Transcription Factor Targets 1.0 null GSE213588_8_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null COV644 DepMap CRISPR Gene Dependency 1.0 2.31743 Nucleus prepositus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19592 RPL28 Pathway Commons Protein-Protein Interactions 1.0 null Chronic Disease HuGE Navigator Gene-Phenotype Associations 1.0 null H2BFS Pathway Commons Protein-Protein Interactions 1.0 null HIST1H2BN Pathway Commons Protein-Protein Interactions 1.0 null MYC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-MECP2-fromNode_MECP2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE141328_1_v_0_rock2_mouse RummaGEO Gene Perturbation Signatures -1.0 null biotin metabolic process GO Biological Process Annotations 2023 1.0 null GTEX-PX3G-0826-SM-48TZS GTEx Tissue Sample Gene Expression Profiles 1.0 0.850617 STAT5A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null coelom TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.279659 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null intracellular membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null GSE134375_6_v_2_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null GSE197630_1_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.427 GATA1-26923725-CHIP-SEQ-HPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.80619 PPP2CA Pathway Commons Protein-Protein Interactions 1.0 null HSPA8 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-OHPL-1026-SM-3MJGI GTEx Tissue Sample Gene Expression Profiles 1.0 0.834102 FU97 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.64466 PC14_LUNG CCLE Cell Line Proteomics 1.0 4.45573 GSE212299_2_v_1_abi3_mouse RummaGEO Gene Perturbation Signatures 1.0 null A704 GDSC Cell Line Gene Expression Profiles 1.0 1.47168 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_3_GSC Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00966 K562_Meprednisone_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0153731 ZSCAN21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.2862 GTEX-O5YT-0007-SM-32PK7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14308 cellular metabolic process GO Biological Process Annotations 2015 1.0 null H3K27ac_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WXYG-0005-SM-3NB3M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49354 H3K27ac_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K47337578 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45703 BRD-K56889360 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0875 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CI-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mccc2 GeneRIF Biological Term Annotations 1.0 null GSE188870,GSE188871_1_v_3_kat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null PHLPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3316 abnormal retina outer nuclear layer morphology IMPC Knockout Mouse Phenotypes 1.0 null organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 PPP2CB Pathway Commons Protein-Protein Interactions 1.0 null influence GeneRIF Biological Term Annotations 1.0 null GSE105169,GSE105175_0_v_1_dhx36_human RummaGEO Gene Perturbation Signatures 1.0 null biotin metabolic process GO Biological Process Annotations 2025 1.0 null BRD-K38737333 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48083 GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles -1.0 -2.21876 KATOIII_STOMACH CCLE Cell Line Proteomics 1.0 2.34738 amino acid catabolic process GO Biological Process Annotations 2025 1.0 null GSE148263_6_v_0_trim3_human RummaGEO Gene Perturbation Signatures 1.0 null BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNMC-0826-SM-4DM66 GTEx Tissue Sample Gene Expression Profiles 1.0 3.21045 GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.68165 mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.69839 MAX_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null rostral presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.990068 GTEX-OXRN-0526-SM-2I5EN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.938917 TRIM28 ENCODE Transcription Factor Targets 1.0 null labetalol-1550 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-OOBJ-0826-SM-3NB2K GTEx Tissue Sample Gene Expression Profiles 1.0 1.09779 H3K4me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null A549_Vandetanib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.013904 TE10 CCLE Cell Line Gene CNV Profiles 1.0 2.9293 GTEX-XMK1-0005-SM-4B665 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02742 H3K27ac_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE179531_1_v_0_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null SOCS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63893 Liver hepatocellular carcinoma_LIHC_TCGA-MR-A520-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF189 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.9338 HCT15 DepMap CRISPR Gene Dependency 1.0 2.00102 HIST3H2BB Pathway Commons Protein-Protein Interactions 1.0 null GSE168401_1_v_0_harmine_human RummaGEO Drug Perturbation Signatures 1.0 null TCF12_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6X0-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.82815 viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-QDT8-0006-SM-32PL3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.997488 HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.855289 H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-8133-01A-12R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2 Rummagene Transcription Factor Associations 2026 1.0 null organelle envelope COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 hESC_Derived_CD56+_Ectoderm_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.13547 GSE155852_0_v_2_apigenin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Nicotine addiction_Ganglioneuroblastoma_GSE11208 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.17437 GSE164463_0_v_1_pax6_mouse RummaGEO Gene Perturbation Signatures -1.0 null OVMIU DepMap CRISPR Gene Dependency 1.0 9.0101 ETS1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Fluorouracil_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0222736 PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S11-Table_S11_MR_resluts_of_brain_pQTL_and_any_stroke_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null dorsolateral prefrontal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.89092 CLINDAMYCIN-PO4 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89261 5447_NADSYN1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.815327 Autosomal dominant disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.034 GSE142684_0_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null Defective MMAA causes methylmalonic aciduria type cblA Reactome Pathways 2014 1.0 null Adult_Liver Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.30758 BRD-K16717067 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50393 cytosol COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 MCF7_FLLL32_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0172537 Anterior hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06842 GSE202434,GSE202438_4_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A.TP53.M_24H:I09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0621 Parasitic protozoa infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.454 GSE227891_2_v_0_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null SEPTIN11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31886 posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.933199 MFE-280 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.28676 GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17277 PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_right-x_TFEB_KOcon_VS_WTcon_UP_TFEB Rummagene Transcription Factor Associations 2026 1.0 null SUM1315MO2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.69745 primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.27895 Gaucher's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.271 GSE206226_2_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Learning Disorders CTD Gene-Disease Associations 1.0 1.80265 Isocitrate dehydrogenase complex (NAD+) COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.524 aminoglycoside-induced deafness DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.95 amygdaloid complex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.1572 Tyrosinemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.04 cofactor metabolic process GO Biological Process Annotations 2015 1.0 null BL2500 (DOT1L) NURSA Protein Complexes 1.0 null ATF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11513043-41525_2024_436_MOESM1_ESM.pdf-45-MAX_1_MAX Rummagene Transcription Factor Associations 2026 1.0 null GTEX-T8EM-0326-SM-3DB7F GTEx Tissue Sample Gene Expression Profiles 1.0 1.03769 CRCGN016_MCF10A.WT.HP_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.32431 NUGC-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.896032 ABCF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22713 Disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.295 GTEX-R53T-1626-SM-3GAEW GTEx Tissue Sample Gene Expression Profiles 1.0 4.38013 GTF2F1 ENCODE Transcription Factor Targets 1.0 null USF1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K44803159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09896 USF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PML_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE215086_5_v_6_batf_human RummaGEO Gene Perturbation Signatures 1.0 null H3K18ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-3006-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8202205-NIHMS1706275-supplement-Table_S3.xlsx-Day_2_GATA6-dependent_genes-GATA6-dependent_mRNA_expression_Day_2_Mesendoderm_FDR_0_05_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null BRD-K11596967 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55243 H3K4me1_Peripheral Blood Mononuclear Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 15793299-TableC GeneSigDB Published Gene Signatures 1.0 null Perturb_7125_KO_Prkce_SRP049245 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.3334 RPS13 Pathway Commons Protein-Protein Interactions 1.0 null PFDN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25441 HCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.75114 Blood TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.367 magnocellular division of VA Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01862 rpmi8226 HPA Cell Line Gene Expression Profiles 1.0 0.988952 GSE223008_4_v_12_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M7-01A-12R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PLZ5-1826-SM-3NB22 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08403 r6 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.43424 GSE158197_6_v_10_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_brain microvascular endothelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hESC_Derived_CD56+_Mesoderm_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -2.57414 interstitial nucleus of the posterior limb of the anterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.78648 RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3187-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 CBX3 ENCODE Transcription Factor Targets 1.0 null r1 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71993 H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 16715129-Table2 GeneSigDB Published Gene Signatures 1.0 null blood GTEx Tissue Gene Expression Profiles -1.0 -1.46526 ATP5A1 Pathway Commons Protein-Protein Interactions 1.0 null SLC25A32 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72709 GSE48812_9_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GSE148010,GSE148120_3_v_2_tet2_human RummaGEO Gene Perturbation Signatures 1.0 null MCF7_Andarine_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0151757 mediodorsal nucleus of thalamus_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.857802 HCST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15148 GSE207514,GSE207515_1_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures -1.0 null HIST2H3A Pathway Commons Protein-Protein Interactions 1.0 null Defective AMN causes hereditary megaloblastic anemia 1 Reactome Pathways 2014 1.0 null GSE154081_3_v_0_sildenafil_mouse RummaGEO Drug Perturbation Signatures 1.0 null Parkinson's disease 6 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.553 other GeneRIF Biological Term Annotations 1.0 null K562_Regorafenib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0185686 hsa-miR-105 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GTEX-QLQ7-0826-SM-447B3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.857024 GTEX-WHSE-1126-SM-3NMBU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827961 GTEX-PWCY-0226-SM-48TD8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22276 parkinsonism GWASdb SNP-Phenotype Associations 1.0 1.40061 Perturb_8409_KO_Yap1/Wwtr1_SRP143461 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -10.8261 mitochondrion GO Cellular Component Annotations 2015 1.0 null YBX1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K41762421 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05069 GTEX-U3ZM-0226-SM-4DXTA GTEx Tissue Sample Gene Expression Profiles 1.0 1.73582 ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rostral division of OFCi (area 11) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04293 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null EP300_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cyproheptadine-1938 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A65J-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE227891_5_v_3_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SF-1326-SM-4AD4P GTEx Tissue Sample Gene Expression Profiles 1.0 0.941776 PPP2R2B Pathway Commons Protein-Protein Interactions 1.0 null Caudoputamen Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16077 PMC2768459-6605275x5.xls-Hoja1-Supplementary_Table_S2_Differentially_expressed_genes_within_the_ESR1-negative_BRCA1_tumors_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null monocarboxylic acid binding GO Molecular Function Annotations 2015 1.0 null BRD-K49742819 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.36691 Sieve cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.753 H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.78471 PMC7218999__F7 PFOCR Pathway Figure Associations 2024 1.0 null STAT3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27765 Ceramide (d18:1/16:0) HMDB Metabolites of Enzymes 1.0 null GTEX-S341-1626-SM-3K2B8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.84292 Lung adenocarcinoma_LUAD_TCGA-97-A4M2-01A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 4578_LIG1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.59189 MYB_01_48 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.5938 K562_Trametinib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0120555 hematopoietic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057226 Perturb_3223_KO_Nhe1_SRP366933 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.36337 Medium chain acyl-CoA dehydrogenase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.903 Placenta BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.61898 MCF7_Thiotepa_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0147309 MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4UY-0226-SM-3K2AP GTEx Tissue Sample Gene Expression Profiles 1.0 1.2752 GTEX-RWS6-0226-SM-2XCA9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.63779 TT CCLE Cell Line Gene Expression Profiles 1.0 1.44267 H3K9ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Procentriole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.729 Argininosuccinic aciduria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.169 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A7Q1-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:B21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06228 H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.14755 GSE158182_5_v_0_pnpla3_human RummaGEO Gene Perturbation Signatures -1.0 null 3-methylcrotonyl CoA carboxylase 1 deficiency CTD Gene-Disease Associations 1.0 2.88009 GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -2.40764 H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null PPP4C Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Dacinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00990489 BRD-K37961770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.03754 esculin-6310 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE118816_2_v_3_myo1c_human RummaGEO Gene Perturbation Signatures -1.0 null spasticity HPO Gene-Disease Associations 1.0 null LB996-RCC Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.79444 targeting GeneRIF Biological Term Annotations 1.0 null PMC9490984-12929_2022_858_MOESM7_ESM.xlsx-MRF-GeneSymbol_MYRF Rummagene Transcription Factor Associations 2026 1.0 null GSE211989_0_v_1_nlrc3_mouse RummaGEO Gene Perturbation Signatures -1.0 null MDAMB157_BREAST CCLE Cell Line Proteomics 1.0 2.11601 MDAMB453_BREAST CCLE Cell Line Proteomics 1.0 2.39228 dorsal preisthmic part of periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20399 G122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44806 BRD-K28522188 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19796 H3K4me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null medial part of r2B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03521 SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Globus pallidus, external segment Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.11812 MCF7_Capecitabine_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160887 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.70803 GTEX-T5JW-0005-SM-3GADE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.88278 membrane-enclosed lumen GO Cellular Component Annotations 2015 1.0 null K562_Tubastatin A HCl_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0209769 GSE147876,GSE147877_2_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Weight Gain CTD Gene-Disease Associations 1.0 1.35012 GSE116810_5_v_3_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07038 episodic metabolic acidosis HPO Gene-Disease Associations 1.0 null HCC1599 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14352 AD-16-HL96_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.416543 K562_Thalidomide_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0179622 POLR2AphosphoS5_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null six GeneRIF Biological Term Annotations 1.0 null GTEX-XPVG-0526-SM-4B65N GTEx Tissue Sample Gene Expression Profiles 1.0 1.0651 BE-79-QU25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.440474 GTEX-T6MN-0005-SM-32PLJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48459 GSE123734_1_v_0_mien1_human RummaGEO Gene Perturbation Signatures -1.0 null MAX_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mo-T Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.58307 GTEX-XYKS-0005-SM-4BRUD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28605 PA-1 GDSC Cell Line Gene Expression Profiles -1.0 -2.1874 c2c12 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.217974 GTEX-U8T8-1426-SM-3DB9H GTEx Tissue Sample Gene Expression Profiles -1.0 -0.871927 Lateral reticular nucleus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.14358 FAU Pathway Commons Protein-Protein Interactions 1.0 null Internal capsule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.711 neurological GAD High Level Gene-Disease Associations 1.0 0.298214 1395_CDC26_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.652032 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Field CA3, stratum lacunosum-moleculare Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18674 cardiovascular system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE108500_1_v_0_foxp1_human RummaGEO Gene Perturbation Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1599 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.890183 hsa-miR-3165 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 IZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.89144 CRCGN008_HEPG2_24H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0397 r9 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09337 Perturb_10356_KD_BRD4_SRP093774 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 BRD-K19526326 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17255 PPARA_KO_GDS2886_484_mouse_small intestine GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K66865641 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.94619 hippocampus (hippocampal formation)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.00068 NELFE ENCODE Transcription Factor Targets 1.0 null STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE199899_1_v_0_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5876-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFE2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K25718133 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06679 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null organelle membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 Leucine isoleucine and valine metabolism WikiPathways Pathways 2024 1.0 null leucine catabolic process GO Biological Process Annotations 2015 1.0 null EGFR_drugactivation_20_GDS2146 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.92106 SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null liver HPA Tissue Protein Expression Profiles -1.0 -2.15828 GSE228727_2_v_0_dapagliflozin_mouse RummaGEO Drug Perturbation Signatures -1.0 null CLK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7657 GSE190316,GSE190324_6_v_9_rbm4_human RummaGEO Gene Perturbation Signatures 1.0 null FOXA2 ENCODE Transcription Factor Targets 1.0 null GSE94849_1_v_4_pinometostat_human RummaGEO Drug Perturbation Signatures 1.0 null Skeletal Muscle Female Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.13031 ABC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.960323 CRCGN012_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.20785 Cerebral creatine deficiency syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.147 H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Alzheimer Disease CTD Gene-Disease Associations 1.0 1.10942 NCIH460 CCLE Cell Line Gene Expression Profiles -1.0 -2.40059 OGDHL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00166 cerebral cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.07669 Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-7082-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.847921 GTEX-WOFM-0126-SM-3MJFE GTEx Tissue Sample Gene Expression Profiles 1.0 1.27253 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE244072_10_v_9_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsal thalamus_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.865185 NCIH2887 DepMap CRISPR Gene Dependency 1.0 8.15976 Entorhinal area, medial part, ventral zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24793 PMC6201690__F1 PFOCR Pathway Figure Associations 2023 1.0 null H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HSF1_KD_GDS1733_756_human_HeLa cells - 2 Hour by siHSF1_2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Electron transfer flavoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.236 SP1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AMPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01124 Bladder Urothelial Carcinoma_BLCA_TCGA-R3-A69X-01A-22R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE228413_2_v_1_mavs_mouse RummaGEO Gene Perturbation Signatures 1.0 null CoA carboxylase activity GO Molecular Function Annotations 2025 1.0 null PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null USF2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:M15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.48615 Perihypoglossal nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18502 metal ion binding GO Molecular Function Annotations 2015 1.0 null Joubert syndrome 23 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.586 r6 part of nucleus prepositus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38074 PHF8 ENCODE Transcription Factor Targets 1.0 null periventricular stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65679 YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37177 GSE77108_8_v_1_saha_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-S95S-0002-SM-3NM8K GTEx Tissue Sample Gene Expression Profiles 1.0 1.2126 GSE65617_0_v_4_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-R55G-0126-SM-48FDS GTEx Tissue Sample Gene Expression Profiles 1.0 0.978626 BRD-A68427178 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.20457 RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null REST_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ar_21330406_lncap_lof_human_gpl570_gds4113 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.20809 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V7-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GSE217132_0_v_1_pfkfb4_human RummaGEO Gene Perturbation Signatures 1.0 null ECEL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23904 GSE114992,GSE114993_0_v_5_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93X-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114690_1_v_0_tnfsf14_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE48812_8_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null r11 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28678 GSE179880_10_v_6_e2f4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Metabolism, Inborn Errors HuGE Navigator Gene-Phenotype Associations 1.0 null H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE239688_2_v_1_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-NL3H-0006-SM-2I3FW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92869 GSE239688_2_v_3_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null MCF7_Roscovitine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0157622 KNS-62 GDSC Cell Line Gene Expression Profiles 1.0 1.55638 H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HPAF-II Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.53838 BRD-K85736239 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41731 USF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MCF7_PD98059_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0177853 BC-56-CP81_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.266896 FOXM1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_CD34 Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SC-251 (E2F1) NURSA Protein Complexes 1.0 null TCF4-23295773-U87-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE116810_2_v_0_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K74600148 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00199 TAF1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MM370 DepMap CRISPR Gene Dependency 1.0 2.57973 VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.36218 BRD-K62683350_T5220758_NPC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MCF7_Valproic acid sodium salt_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0201582 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.232386 PLXND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14946 SNRPA1 Pathway Commons Protein-Protein Interactions 1.0 null TAF1_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210655_1_v_4_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE220520_3_v_9_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null ZEB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.3624 BL7015 (ZNF8) NURSA Protein Complexes 1.0 null RPLP1 Pathway Commons Protein-Protein Interactions 1.0 null H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF214 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.5477 LB771-HNC COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 organelle membrane GO Cellular Component Annotations 2015 1.0 null Fibrosis CTD Gene-Disease Associations 1.0 1.22884 Mucinous cystadenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.001 purine ribonucleotide binding GO Molecular Function Annotations 2015 1.0 null mitochondrial inner membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OAW42 DepMap CRISPR Gene Dependency 1.0 4.62068 mainland GeneRIF Biological Term Annotations 1.0 null DDX1 Pathway Commons Protein-Protein Interactions 1.0 null growth abnormality HPO Gene-Disease Associations 1.0 null GTEX-R55E-0006-SM-2TC5G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.988822 striatum_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.00068 GTEX-T6MO-0126-SM-4DM6X GTEx Tissue Sample Gene Expression Profiles 1.0 0.889864 GSE230744,GSE237803_5_v_3_hira_human RummaGEO Gene Perturbation Signatures -1.0 null GSE215086_0_v_1_batf_human RummaGEO Gene Perturbation Signatures -1.0 null TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-5931-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TFAP2C_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1944 CCLE Cell Line Gene Expression Profiles -1.0 -1.7081 ZNF384_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle part GO Cellular Component Annotations 2015 1.0 null intracellular COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.231672 BL3923 (PPP4C) NURSA Protein Complexes 1.0 null Nucleus ambiguus, ventral division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10417 PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-548f TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Cardiac muscle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D3_1784_AR-DEGS-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null KYSE-70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.68059 Sphingolipidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.236 H3K79me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Fasudil_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0180514 4950_MED27_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.726303 GSE258991_1_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08847 BRD-K24156533 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44789 Perturb_10910_KO_Thbs1_SRP276889 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.60311 7501_RPS13_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.799504 kidney_b HPA Tissue Sample Gene Expression Profiles 1.0 1.37941 HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LN-18 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.985368 SMAD3 ChEA Transcription Factor Targets 1.0 null A549_Ruxolitinib_10nM_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0140937 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Biotin-binding site InterPro Predicted Protein Domain Annotations 1.0 null K562_JQ1_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0220667 TAF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09758 ATF3_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Z-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.WT.HP_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9556 PMC3255316__F1 PFOCR Pathway Figure Associations 2023 1.0 null membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 GSE138050,GSE148257_1_v_2_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null area postrema Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.19321 GSE221327_4_v_9_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null SMC3 ENCODE Transcription Factor Targets 1.0 null MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.24594 medial part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12139 BRD-K83949633 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11338 H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Defective CD320 causes methylmalonic aciduria Reactome Pathways 2014 1.0 null FOXM1-26456572-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE197850_4_v_0_glucagon_human RummaGEO Drug Perturbation Signatures -1.0 null T47D CCLE Cell Line Gene Expression Profiles 1.0 2.32502 WRNIP1 ENCODE Transcription Factor Targets 1.0 null PMC8602451-41467_2021_26807_MOESM8_ESM.xlsx-SALL1_SUMO-ID-Gene_name_SALL1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-TMMY-0926-SM-33HBG GTEx Tissue Sample Gene Expression Profiles 1.0 1.96908 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null GSE102675_2_v_1_atf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-A25184723 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41761 parkinsons GeneRIF Biological Term Annotations 1.0 null GTEX-T5JW-1726-SM-3GADN GTEx Tissue Sample Gene Expression Profiles 1.0 0.988428 nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.498849 293n3s TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.178 catalytic complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.050596 NOL11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05812 H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H4K20me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CD56+_NKCells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.868631 GSE248858_6_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null SNU-C5 COSMIC Cell Line Gene Mutation Profiles 1.0 null Hs-445 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.17009 r11 part of spinal trigeminal nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.94968 intracellular organelle GO Cellular Component Annotations 2015 1.0 null Kidney Diseases CTD Gene-Disease Associations 1.0 1.68889 H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null BRD-K29331543 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16179 GSE77108_4_v_1_saha_human RummaGEO Drug Perturbation Signatures -1.0 null GSE130246_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K01152687 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8105 anion binding GO Molecular Function Annotations 2015 1.0 null PMC11892598-pnas.2417308122.sd05.xlsx-DEGs_of_RORC_cluster-Unnamed_2_RORC Rummagene Transcription Factor Associations 2026 1.0 null BRD-K70618663 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36174 CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K70851631 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46259 Perturb_12649_KD_DIRC3_SRP191422 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE188869,GSE188871_2_v_3_kat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-A16119053 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29296 water-soluble vitamin metabolic process GO Biological Process Annotations 2025 1.0 null K562_SNS-314 Mesylate_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0207844 GSE218727_2_v_1_zkscan3_human RummaGEO Gene Perturbation Signatures 1.0 null CDCA4 Pathway Commons Protein-Protein Interactions 1.0 null SF1_01_146 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.61594 ATP-grasp fold, subdomain 2 InterPro Predicted Protein Domain Annotations 1.0 null XBP1_01_204 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60075 P2RY4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00693538 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054569 mantle zone of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79467 KMOE-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null acute hyperammonemia HPO Gene-Disease Associations 1.0 null OAW28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.21741 PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2 Rummagene Transcription Factor Associations 2026 1.0 null risk GeneRIF Biological Term Annotations 1.0 null Brain - Putamen (basal ganglia) GTEx Tissue Gene Expression Profiles 2023 1.0 0.739637 r2 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12321 MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF4_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158197_2_v_3_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null 20460542-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null Multiple acyl-CoA dehydrogenase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.213 GSE242096,GSE242098_1_v_0_med1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MCF7_Raltitrexed_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0100363 Brain Lower Grade Glioma_LGG_TCGA-VV-A829-01A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE207282_1_v_0_polydatin_human RummaGEO Drug Perturbation Signatures -1.0 null MM.1S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.21863 Depressive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.406 PDE5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07916 H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CRIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50897 cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26957 BRD-K63887881 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.94769 hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05658 POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7595-01A-11R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TMZS-0001-SM-3P61Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.16867 SIN3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K06002536 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1711 GSE149880_2_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUJ4-1426-SM-4BONT GTEx Tissue Sample Gene Expression Profiles 1.0 1.587 Perturb_6029_KD_KHDRBS3_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 PMC7587013-GLIA-68-2613-s005.xlsx-ASCL1_Putative_Targets-Overlapping_Genes_ChIP-seq_8791_ASCL1_Assoc_Genes_vs_TCGA_RNA-seq_2136_Top_10_ASCL1-positively_Correlated_Genes_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null GSE215351,GSE215794_4_v_3_kdm8_mouse RummaGEO Gene Perturbation Signatures -1.0 null rostral migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.84346 kidney_d HPA Tissue Sample Gene Expression Profiles 1.0 1.38186 BRD-K98510376 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.436 GSE164529_0_v_2_tamoxifen_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_MCF10A_48H:F24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.26525 mutant GeneRIF Biological Term Annotations 1.0 null GSE76771_2_v_3_atf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null Hepatomegaly CTD Gene-Disease Associations 1.0 1.04647 MCF7_Temsirolimus_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0134192 FOXA1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6023-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null small molecule binding GO Molecular Function Annotations 2015 1.0 null DCD Pathway Commons Protein-Protein Interactions 1.0 null PHB2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K72488042 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44564 GSE125007,GSE125008_1_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null HLE CCLE Cell Line Gene Expression Profiles -1.0 -2.03056 H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BFTC-905 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14518 GSE216273,GSE216292_0_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null USF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.881 GSE144443_0_v_1_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S3XE-1226-SM-4AD4L GTEx Tissue Sample Gene Expression Profiles 1.0 1.13697 GSE233049_1_v_3_atf3_human RummaGEO Gene Perturbation Signatures 1.0 null H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mitochondrion COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-7521-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCP1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CBX3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE147876,GSE147877_4_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null PMC11908325-media-2.xlsx-Table10_MR-Unnamed_2_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GSE192771_2_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null HOXC11 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.4266 MCF7_Ruxolitinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0211379 GSE209598_1_v_2_tgfbr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lipid storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.128 GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74557 Brain Lower Grade Glioma_LGG_TCGA-S9-A6TZ-01A-21R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.938273 RSV_4Hour_19459069_GSE3397 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.89857 REST_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null u2197 HPA Cell Line Gene Expression Profiles -1.0 -0.865106 JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adipocyte BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.53012 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE223609,GSE223610_0_v_1_kdm6a_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-UPK5-0006-SM-3GAD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04996 CAL-85-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 cerebellar cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.26181 Hypertension CTD Gene-Disease Associations 1.0 1.04721 abnormality of acid-base homeostasis HPO Gene-Disease Associations 1.0 null NCI-H2052 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33622 EEF1D Pathway Commons Protein-Protein Interactions 1.0 null GSE250560_1_v_0_foxo1_mouse RummaGEO Gene Perturbation Signatures 1.0 null cytoplasmic part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 EEF1B2 Pathway Commons Protein-Protein Interactions 1.0 null GNAT2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00528909 Nodulus (X), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41114 SmoothMuscle BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.32175 BRD-K62976536 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20845 BRD-K30853940 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24101 Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1941 BRD-K46056750_AZD-7762_HT29_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null abducens nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.982008 TEAD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRL-0526-SM-2I3EZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.02944 PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A Rummagene Transcription Factor Associations 2026 1.0 null GSE134375_6_v_5_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null sulfur compound binding GO Molecular Function Annotations 2015 1.0 null BRD-K38131403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19252 primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.861724 H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Combined oxidative phosphorylation deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.37 PMC9546828-41389_2022_435_MOESM4_ESM.xlsx-Table_S3-Table_S3_Downregulated_genes_upon_ZNF148_knockdown_P_adj_0_05_Fold_change_1_5_ZNF148 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K40001806 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03287 ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66512 SOX9 ChEA Transcription Factor Targets 1.0 null GSE193402_0_v_3_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null STAT3 ENCODE Transcription Factor Targets 1.0 null GSE123638,GSE123639_0_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1 ENCODE Transcription Factor Targets 1.0 null GTEX-SUCS-0926-SM-4DM4Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.19289 sufficient GeneRIF Biological Term Annotations 1.0 null GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL22 Pathway Commons Protein-Protein Interactions 1.0 null GSE160246_9_v_1_cpeb4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE235550_2_v_0_hspa9_human RummaGEO Gene Perturbation Signatures 1.0 null intracellular COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 PPIA Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Costunolide_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0213067 Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8RZ-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92512 MAFA MotifMap Predicted Transcription Factor Targets 1.0 null Branched-chain amino acid catabolism Reactome Pathways 2024 1.0 null GTEX-WY7C-2726-SM-3NB3P GTEx Tissue Sample Gene Expression Profiles 1.0 0.905966 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NFYB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM1A ENCODE Transcription Factor Targets 1.0 null MCF7_Glesatinib(MGCD265)_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0151546 ventrolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.848699 KYSE140 DepMap CRISPR Gene Dependency 1.0 2.48566 Tricarboxylic acid cycle enzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.269 4953_MED30_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.50123 SCN10A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0055633 GSE147876,GSE147877_2_v_5_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null RV16_0Hour-B2B_None_GSE28904 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.14954 HCC1576 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.985368 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6487-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 11823860-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null TE5 CCLE Cell Line Gene CNV Profiles 1.0 1.36077 gemcitabine_homo sapiens_gpl96_gse6914 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.87957 18451145-TableS1 GeneSigDB Published Gene Signatures 1.0 null SBC-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null 1331_CCNJ_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.566842 CREB1 ENCODE Transcription Factor Targets 1.0 null Monogenic disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 5.0 MBD4 ENCODE Transcription Factor Targets 1.0 null PKCTHETA-26484144-CHIP-SEQ-BREAST-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE242199_2_v_3_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null LGE-VZ border region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01829 membrane-enclosed lumen COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 BRD-K90127324 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08823 CRCGN008_HEPG2_24H:J06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1125 Ethylmalonic encephalopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.065 SUZ12 ENCODE Transcription Factor Targets 1.0 null Lingula (I), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.08002 A549_CUDC-101_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0195 Prostate adenocarcinoma_PRAD_TCGA-FC-A4JI-01A-11R-A250-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5463-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE111247_11_v_5_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2988-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AU565 CCLE Cell Line Gene Expression Profiles 1.0 1.58043 GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.11066 HNRNPR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50257 K562_Sorafenib Tosylate_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0157379 USF1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null V, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.834874 GSE241036_0_v_1_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-VUSG-2426-SM-4KKZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.43199 BRD-K33953218 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15241 MRPS27 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE48812_2_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Divalproex Sodium_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0238173 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.897 H3K27ac_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KASUMI2 CCLE Cell Line Gene CNV Profiles -1.0 -2.07647 GSE153189_2_v_3_interferon gamma_mouse RummaGEO Drug Perturbation Signatures -1.0 null gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.056336 TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 18757322-TableS1 GeneSigDB Published Gene Signatures 1.0 null GSE126776_0_v_1_pelp1_human RummaGEO Gene Perturbation Signatures 1.0 null STAT5A-24692510-EPITHELIUM-MOUSE-MAMMARY ChEA Transcription Factor Targets 2022 1.0 null GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10276 GSE188870,GSE188871_0_v_2_kat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null Pericentriolar material COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.903 mitochondrial envelope COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 Parasitic infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.414 azotemia HPO Gene-Disease Associations 1.0 null H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null metabolic acidosis HPO Gene-Disease Associations 1.0 null BRD-K52911425_GDC-0941_HEPG2_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K27ac_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null L-540 GDSC Cell Line Gene Expression Profiles -1.0 -2.42203 3-Methylcrotonyl-CoA carboxylase 1 deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.508 PMC6918611-13073_2019_694_MOESM1_ESM.xlsx-Zfp57_binding_sites-Additional_file_1_Supplementary_Table_1_List_of_ZFP57_binding_sites_in_gDMRs_ZFP57 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5986-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE136627_2_v_1_hdac4_mouse RummaGEO Gene Perturbation Signatures -1.0 null medial preoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15351 BF-79-GG96_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.217906 upper (rostral) rhombic lip_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.89729 Dystonia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.106 IFIT3 Pathway Commons Protein-Protein Interactions 1.0 null GSE148066,GSE157787_0_v_7_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null T47D Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.30489 A549_Trichostatin A_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00759825 7566_RRP7A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.551704 3-Methylcrotonyl-CoA carboxylase deficiency Reactome Pathways 2024 1.0 null POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Major depressive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.146 Lung adenocarcinoma_LUAD_TCGA-78-7167-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior cortical amygdaloid area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.29811 neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.615529 Drug-Induced Acute Liver Injury DisGeNET Gene-Disease Associations 1.0 null GSE226249_0_v_1_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EAF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86742 mantle zone of r11Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.9491 GSE215086_8_v_7_batf_human RummaGEO Gene Perturbation Signatures -1.0 null NPM1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QVUS-0006-SM-3GAE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.977476 vascular system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE216043_3_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Anteromedial visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.81718 superficial stratum of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27051 ASIC3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0062184 GSE134214_0_v_1_ell2_human RummaGEO Gene Perturbation Signatures -1.0 null SIRT6 ENCODE Transcription Factor Targets 1.0 null BRD-K93283197 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25167 Sarcoma_SARC_TCGA-VT-A80J-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF384 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RM2N-0826-SM-48FD3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.891943 USF1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_PJ34_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0147379 A-VN-1203-2004(H5N1)_Day1-10^4pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.63599 BRD-K57270624 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.68637 Lung adenocarcinoma_LUAD_TCGA-78-8662-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null all HPO Gene-Disease Associations 1.0 null endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052359 dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.881193 JHUEM1 DepMap CRISPR Gene Dependency 1.0 2.75644 TOV-21G COSMIC Cell Line Gene Mutation Profiles 1.0 null ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_6022_KD_HNRNPK_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE210655_1_v_5_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.83999 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NCI-H441 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.975065 Perturb_17196_OE_HER2_SRP166112 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 MYC_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWN1-1626-SM-2S1OL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.898036 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27ac_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-OIZH-1326-SM-3NB1H GTEx Tissue Sample Gene Expression Profiles 1.0 0.956348 GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.00856 H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZKSCAN1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ6-0426-SM-2I5FG GTEx Tissue Sample Gene Expression Profiles 1.0 1.14885 RT-112 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.96626 NCIH2170 CCLE Cell Line Gene CNV Profiles -1.0 -1.41601 H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Muscle tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.106 SPI1-23127762-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K74251295 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10862 carbohydrate derivative binding GO Molecular Function Annotations 2015 1.0 null BRD-K55844427_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE213588_8_v_2_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5690-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REM sleep behavior disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.21 Perturb_14528_KO_Gata4_SRP111204 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.56811 BRD-K96416345 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91041 NFIC_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE206779_4_v_2_angiotensin ii_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WFJO-0005-SM-3GIKY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4755 BRD-K21588993 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.71073 POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A852-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29G-06A-12R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC4486168-pone.0131961.s006.xlsx-Sheet1-ARID3B_Upregulated_Genes_ARID3B Rummagene Transcription Factor Associations 2026 1.0 null COR-L47 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.33424 PMC12019336-41467_2025_58868_MOESM5_ESM.xlsx-Open_peaks_IKAROS_WT-Unnamed_5_IKZF1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE237040_6_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null SETDB1 ENCODE Transcription Factor Targets 1.0 null CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5871 H3K4me1_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 3-methylcrotonyl-CoA carboxylase deficiency DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 5.0 PMC11513043-41525_2024_436_MOESM1_ESM.pdf-45-MAX_MAX Rummagene Transcription Factor Associations 2026 1.0 null USF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE166914_1_v_0_abemaciclib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K70407915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1659 BRD-K35123860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13115 ZNF708 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.6207 K562_GSK J1_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146134 GSE148510_3_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S12-Table_S12_MR_resluts_of_brain_pQTL_and_any_ischemic_stroke_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null valine leucine and isoleucine degradation KEGG Pathways 1.0 null amino acid catabolic process GO Biological Process Annotations 2023 1.0 null 7754_SEC62_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.2931 3-methylcrotonyl-coa carboxylase 1 deficiency OMIM Gene-Disease Associations 1.0 null GTEX-OIZH-3026-SM-3NB1G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.891224 GSE125153_1_v_0_bcl3_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.491978 MCF7_S3I-201_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.016046 CRCGN015_HEPG2_48H:A13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.63961 primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.844353 primary auditory cortex (core)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.95406 NCI-H28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.896032 H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null E2F6_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AU565 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.680711 MMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18933 Crus II, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.849592 dorsal thalamus_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40887 REST_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL15 Pathway Commons Protein-Protein Interactions 1.0 null FOXP2_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null plastid-encoded plastid RNA polymerase complex A COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.391 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_WT-Unnamed_1_ZNF385A Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WEY5-1326-SM-3GILS GTEx Tissue Sample Gene Expression Profiles 1.0 0.950311 inner CP in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.872773 BRD-K72685049 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00138 MCF7_Momelotinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.022088 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5454-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.417 carboxylic acid catabolic process GO Biological Process Annotations 2015 1.0 null KPNB1 Pathway Commons Protein-Protein Interactions 1.0 null H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null COV362_OVARY CCLE Cell Line Proteomics 1.0 2.11827 parvocellular part of r8LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.68209 PSMC3IP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49059 RELA_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.791044 ABC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.2827 RERF-LC-SQ1 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 chr3_183014142_C_T_b38 GTEx eQTL 2025 1.0 3.78442 CRCGN013_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.72532 neonate TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.367876 HSP90AB1 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN011_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4594 Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A61V-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferior olivary complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.896453 GTEX-XBEW-0226-SM-4AT6A GTEx Tissue Sample Gene Expression Profiles 1.0 0.84055 hsa-miR-488 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 Isovaleric acidemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.982 mediodorsal nucleus of thalamus_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.8859 Gut TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.167 MEF2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.6238 DIPK1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00429803 MCF7_Quisinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0132463 decreased body weight HPO Gene-Disease Associations 1.0 null ZNF354C JASPAR Predicted Transcription Factor Targets 1.0 null PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S27_LF_C2_24h-Unnamed_5_LTF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XGQ4-0826-SM-4AT4T GTEx Tissue Sample Gene Expression Profiles 1.0 2.57792 BRD-K48756106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10639 GSE215086_3_v_0_batf_human RummaGEO Gene Perturbation Signatures 1.0 null HCC95 CCLE Cell Line Gene CNV Profiles 1.0 1.86529 GSE246461,GSE246463_5_v_2_mecp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K31917106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53892 BRD-K04363266_-666_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE157383_3_v_1_abemaciclib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE178714_5_v_0_smad2_human RummaGEO Gene Perturbation Signatures 1.0 null plant embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058719 RPL26L1 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN016_MCF10A.WT.HP_24H:G23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.53745 orbital frontal cortex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.966676 PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_BMS-754807_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0144778 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5172 GSE201309_4_v_8_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null TSPYL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2616 all GeneRIF Biological Term Annotations 1.0 null GSE178532_2_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null LU-65 GDSC Cell Line Gene Expression Profiles -1.0 -1.90034 BRD-K37687095_AZD-8330_SKBR3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Pre-ATP-grasp domain InterPro Predicted Protein Domain Annotations 1.0 null mitochondrial part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-XXEK-0726-SM-4BRWF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.930809 GTEX-NL3H-0011-R1a-SM-48TDJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.933507 GSE216043_7_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-NFK9-1726-SM-3TW8P GTEx Tissue Sample Gene Expression Profiles 1.0 1.09737 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null H3K27ac_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null organic acid binding GO Molecular Function Annotations 2015 1.0 null H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null decreased total retina thickness IMPC Knockout Mouse Phenotypes 1.0 null PMC4590705-13062_2015_86_MOESM1_ESM.xlsx-Gene_A_-_TP53-Unnamed_4_TP53 Rummagene Transcription Factor Associations 2026 1.0 null PK-15 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.164 Paraventricular hypothalamic nucleus, parvicellular division, medial parvicellular part, dorsal zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14822 CCRF-SB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10343 CEBPB ENCODE Transcription Factor Targets 1.0 null U-937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0491 MCF7_Streptozotocin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148641 GSE210580_3_v_2_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XOTO-0006-SM-4B64T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38864 USF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K08219814 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36637 primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.93308 CKB Pathway Commons Protein-Protein Interactions 1.0 null PMC8202205-NIHMS1706275-supplement-Table_S3.xlsx-Day_4_GATA6-dependent_genes-GATA6-dependent_mRNA_expression_Day_4_Definitive_Endoderm_FDR_0_05_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K07485506 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26397 PMC9022281-12967_2022_3377_MOESM1_ESM.xlsx-Table_S14-Table_S14_MR_resluts_of_brain_pQTL_and_cardioembolic_stroke_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.846847 MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Dermatomyositis_Muscle - Striated (Skeletal) (MMHCC)_GSE1551 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.78452 BRD-K03618428_PP-110_THP1_6.0_h_22.2_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K79me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_6092_KD_YY2_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE200352_1_v_8_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null Leukocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.367 methylcrotonoyl-CoA carboxylase activity GO Molecular Function Annotations 2025 1.0 null whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 neck TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.078684 9426_TUBGCP3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.46045 Psychotic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.619 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6871-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mitochondrial matrix GO Cellular Component Annotations 2015 1.0 null Diabetes Mellitus, Type 2 CTD Gene-Disease Associations 1.0 1.05423 Acute Myeloid Leukemia_LAML_TCGA-AB-2972-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Phosphoric acid HMDB Metabolites of Enzymes 1.0 null GTEX-T6MO-0003-SM-3NMAG GTEx Tissue Sample Gene Expression Profiles 1.0 1.32103 HD-29-LW24_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.249738 Hematopoietic cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.367 abnormality of the liver HPO Gene-Disease Associations 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nodulus (X) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33584 MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZH-0005-SM-3DB72 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17979 GTEX-P78B-0226-SM-3NB1Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.53808 BRD-K48860650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13431 STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE192771_2_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN008_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.56285 SERBP1 Pathway Commons Protein-Protein Interactions 1.0 null GSE221327_10_v_11_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN013_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.1011 GRANTA-519 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.27009 BRD-K24377650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2155 GSE210655_3_v_0_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K67470788_5867767_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.9474 GTEX-XMK1-0001-SM-4B64F GTEx Tissue Sample Gene Expression Profiles 1.0 0.99217 OCI-LY-19 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K79me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HIST1H2BK Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3358-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-FX-A2QS-11A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Comatose DisGeNET Gene-Phenotype Associations 1.0 null CRCGN017_MCF10A.TP53.M_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.19408 ventral lateral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12653 hsa-miR-3612 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Complement component 6 deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.125 PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_14_CCF-Affected_Genes_PITX1 Rummagene Transcription Factor Associations 2026 1.0 null adipose tissue HPA Tissue Gene Expression Profiles 1.0 0.82544 CRCGN014_HEPG2_24H:G20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1274 SUDHL1 CCLE Cell Line Gene Expression Profiles -1.0 -1.96993 GTEX-XUYS-0005-SM-47JZ2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.91194 pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.383582 K562_SNS-314 Mesylate_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0328291 GSE242083,GSE242098_2_v_1_med1_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN013_HEPG2_24H:L19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.58289 autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.59952 KDM5A ENCODE Transcription Factor Targets 1.0 null GSE86507,GSE86509_0_v_8_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE241036_0_v_3_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-RWSA-0005-SM-2XCAO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10225 PMC12245139-Supplementary_material-Suppl.2-s2.xlsx-Table_S4_AR_transmission-Unnamed_4_AR Rummagene Transcription Factor Associations 2026 1.0 null inhibition GeneRIF Biological Term Annotations 1.0 null PMC8763317-MO-018-D1MO00236H-s002.xlsx-PHF21A_S0_1-Gene_names_PHF21A Rummagene Transcription Factor Associations 2026 1.0 null ventral isthmic part of dorsal raphe nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10915 SUM 149PT Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null CD34+ BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.911084 H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6087-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null neurodevelopmental abnormality HPO Gene-Disease Associations 1.0 null GSE144443_5_v_1_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.89387 GTEX-R55D-0926-SM-3GAEU GTEx Tissue Sample Gene Expression Profiles 1.0 1.68627 OAW28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.62924 K562_EED226_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0140467 GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.993806 Tuberculosis DisGeNET Gene-Disease Associations 1.0 null central nervous system disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.682635 BAG2 Pathway Commons Protein-Protein Interactions 1.0 null PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null HPAF-II GDSC Cell Line Gene Expression Profiles -1.0 -1.77203 ZBTB33 ENCODE Transcription Factor Targets 1.0 null GTEX-W5WG-1126-SM-4LMK4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.4758 K562_Andarine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0147256 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ASPC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.25083 GTEX-UTHO-0006-SM-3NMCC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26267 Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Reactome Pathways 2014 1.0 null Diseases of branched-chain amino acid catabolism Reactome Pathways 2024 1.0 null RPL34 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_1467_KO_Dnttip1_SRP056432 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.41207 GSE239688_2_v_5_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_GM12869_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M8-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K71296038 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62975 SW-480 cell ProteomicsDB Cell Type and Tissue Protein Expression Profiles -1.0 -1.12852 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.9496 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.217 inferior occipital gyrus, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06739 NCI-H1304 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 GSE202825_2_v_1_ano1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WHPG-0004-SM-3NMDO GTEx Tissue Sample Gene Expression Profiles 1.0 0.934463 SMC3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null muscular hypotonia HPO Gene-Disease Associations 1.0 null intermediate stratum of TSPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28842 ZEB1 ENCODE Transcription Factor Targets 1.0 null BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.558272 Mitochondrial matrix COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 metabolic process GO Biological Process Annotations 2015 1.0 null abnormality of muscle physiology HPO Gene-Disease Associations 1.0 null H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Precancerous Conditions CTD Gene-Disease Associations 1.0 1.58842 blast cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.067758 GSE147876,GSE147877_4_v_7_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null CHD2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TUBA1A Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE221327_4_v_2_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null FOXA1 ENCODE Transcription Factor Targets 1.0 null BRD-A64915300 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.96371 BRD-K03067624_EMETINE HYDROCHLORIDE_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_HEPG2_48H:A07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.11671 H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE242199_9_v_5_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 2.00954 GSE148096_1_v_0_erlotinib_human RummaGEO Drug Perturbation Signatures 1.0 null PMC6379092-elife-39598-supp2.xlsx-KLF2_target_genes-OTHER_KLF2 Rummagene Transcription Factor Associations 2026 1.0 null TFAP2C-20629094-MCF7-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12873_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE176093_0_v_1_mineral oil_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-T6MO-1726-SM-33HB8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.4137 RPL10A Pathway Commons Protein-Protein Interactions 1.0 null NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.59997 SERPINE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31753 USF1_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null organelle lumen GO Cellular Component Annotations 2015 1.0 null H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFON-1126-SM-4LVMA GTEx Tissue Sample Gene Expression Profiles 1.0 1.59247 HT1080_SOFT_TISSUE CCLE Cell Line Proteomics 1.0 2.6685 Micronuclei, Chromosome-Defective CTD Gene-Disease Associations 1.0 1.53989 ESR1-26153859-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null Type 2 diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.235 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.942311 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YT-1626-SM-32PK6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.902664 NFIC ENCODE Transcription Factor Targets 1.0 null GSE191015_0_v_3_gsdmb_human RummaGEO Gene Perturbation Signatures -1.0 null GSE240027,GSE240030_1_v_4_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null optic nerve disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.241196 GSE226091,GSE226092_0_v_1_sall1_mouse RummaGEO Gene Perturbation Signatures 1.0 null upper (rostral) rhombic lip_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.61982 anterior (rostral) cingulate (medial prefrontal) cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.4424 K562_Lapatinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0184587 WM3772F DepMap CRISPR Gene Dependency 1.0 2.49102 TCF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAN Pathway Commons Protein-Protein Interactions 1.0 null CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A88461048 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41444 GSE135514_8_v_5_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null EMX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.3951 GTEX-X638-0005-SM-47JX6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00112 intermediate stratum of Str Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04289 BRD-K14255526 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02381 Metabolism of water-soluble vitamins and cofactors Reactome Pathways 2024 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null FJX1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00464823 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45U-01A-12R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZNF217_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBX3_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X62O-0005-SM-46MV1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26539 H3K27me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Striatum dorsal region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16159 WholeBlood BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.53522 Perturb_6008_KD_DDX17_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57322 SKA3 Pathway Commons Protein-Protein Interactions 1.0 null TCF4 ChEA Transcription Factor Targets 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Norwalk Virus_HG23_19515767_GSE15520 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.10576 GSE168233_0_v_1_setdb1_human RummaGEO Gene Perturbation Signatures 1.0 null HOXB4 ChEA Transcription Factor Targets 1.0 null BRD-K39176069 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.35713 H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE149760_0_v_5_elof1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE118532_0_v_1_rnf168_human RummaGEO Gene Perturbation Signatures 1.0 null mitochondrion COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6B6-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of gingiva_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN010_HEPG2_24H:O07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.17402 TAF1_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE211286_4_v_5_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XLM4-0005-SM-4AT4P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05807 GTEX-XUZC-0726-SM-4BOPH GTEx Tissue Sample Gene Expression Profiles 1.0 1.02967 Venom duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.621 an3ca HPA Cell Line Gene Expression Profiles -1.0 -1.12443 Posterior cingulate cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.191 intracellular organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GSE221327_10_v_9_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K31783598 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2847 GSE158197_0_v_11_egfr_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-A71666580 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51414 HCT116 CCLE Cell Line Gene Expression Profiles -1.0 -1.58016 GSE146982_3_v_2_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null superficial stratum of LAP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01082 failure to thrive HPO Gene-Disease Associations 1.0 null POU2F2_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -4.10735 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null USF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Reactome Pathways 2014 1.0 null CRCGN011_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2692 MAP7 Pathway Commons Protein-Protein Interactions 1.0 null inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.73275 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.896032 HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SG in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.64116 SIK2 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16058 GSE101546_2_v_1_setdb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE164529_0_v_3_tamoxifen_human RummaGEO Drug Perturbation Signatures 1.0 null urinary tract TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me2_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Hyperplasia CTD Gene-Disease Associations 1.0 1.69597 GSE102870_3_v_9_nr1h4_human RummaGEO Gene Perturbation Signatures 1.0 null H3K56ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 2624_EML2_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.579749 Postencephalitic Parkinson disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.097 POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Defective HLCS causes multiple carboxylase deficiency Reactome Pathways 2014 1.0 null Organelle lumen COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Alzheimer's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.342 CREB3L4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9304 H3K79me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MDAMB134VI Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.08531 GTEX-PVOW-0008-SM-48TE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.867083 GSE202434,GSE202438_9_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE149901_3_v_1_anlotinib_human RummaGEO Drug Perturbation Signatures -1.0 null SNU182 CCLE Cell Line Gene Expression Profiles -1.0 -1.71562 GTEX-QEG5-0626-SM-2S1PP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00853 CABLES2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04189 MEWO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09255 H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null C1QBP Pathway Commons Protein-Protein Interactions 1.0 null TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4741-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null morphological abnormality of the central nervous system HPO Gene-Disease Associations 1.0 null VCAP CCLE Cell Line Gene Expression Profiles 1.0 1.50135 GSE178714_1_v_0_smad2_human RummaGEO Gene Perturbation Signatures 1.0 null 3-methylcrotonyl-coa carboxylase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 2.52222 SP1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22224 PMC6436215-13073_2019_626_MOESM2_ESM.xlsx-NCM-RORA_RORA Rummagene Transcription Factor Associations 2026 1.0 null BRD-K30727702 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05799 JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEP170 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79668 eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041013 GSE148692,GSE148695_7_v_3_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Mre11 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.2 TEAD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null preweaning lethality, complete penetrance MGI Mouse Phenotype Associations 2023 1.0 null medial amygdala, anterodorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18008 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K16570418 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.87562 GSE186810,GSE186813_7_v_5_furin_mouse RummaGEO Gene Perturbation Signatures 1.0 null TRIM24_knockout_300_GSE19675 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.54097 Type 1 diabetes mellitus_Muscle - Striated (Skeletal) (MMHCC)_GSE1659 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.70205 EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.06113 alitretinoin_homo sapiens_gpl6480_gse43090 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Disease of metabolism DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 5.0 PMC3255316__F1 PFOCR Pathway Figure Associations 2024 1.0 null POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17613 BRD-K38977317 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50968 superior periolivary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48755 carboxylic acid metabolic process GO Biological Process Annotations 2015 1.0 null H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Syndromic microphthalmia 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.322 ZNF384_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL6 Pathway Commons Protein-Protein Interactions 1.0 null SIX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01668 496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.56418 posteroventral (inferior) parietal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02434 amide binding GO Molecular Function Annotations 2015 1.0 null mode of inheritance HPO Gene-Disease Associations 1.0 null GTEX-VUSG-1426-SM-3GIJN GTEx Tissue Sample Gene Expression Profiles 1.0 2.78731 ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Defective CUBN causes hereditary megaloblastic anemia 1 Reactome Pathways 2014 1.0 null HIST1H2BM Pathway Commons Protein-Protein Interactions 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-8277-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE125014_6_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Metabolism of water-soluble vitamins and cofactors Reactome Pathways 2014 1.0 null Neurotoxicity Syndromes CTD Gene-Disease Associations 1.0 1.34694 GTEX-WFG8-0926-SM-3GIKJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.14783 CCT6A Pathway Commons Protein-Protein Interactions 1.0 null CCT4 Pathway Commons Protein-Protein Interactions 1.0 null HCC-202 ProteomicsDB Cell Type and Tissue Protein Expression Profiles 1.0 1.08864 PMC6151027-12864_2018_5080_MOESM4_ESM.xlsx-Amino_Acid_Metabolism_50_AR-DEG-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null excretory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064621 BRD-K58955712 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13832 chr3_183066619_A_G_b38 GTEx eQTL 2025 1.0 1.4357 dorsal juxtacommissural pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12421 H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KYSE-450 GDSC Cell Line Gene Expression Profiles 1.0 1.45097 GSE258991_1_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null mitochondrial membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 RELA_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFE2 ENCODE Transcription Factor Targets 1.0 null ATF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8339 TCF7L2_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE80446_0_v_1_anakinra_mouse RummaGEO Drug Perturbation Signatures -1.0 null catabolic process GO Biological Process Annotations 2015 1.0 null BRD-K27147269 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43571 GSE148692,GSE148695_2_v_3_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim22_KD-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XGQ4-0926-SM-4AT4U GTEx Tissue Sample Gene Expression Profiles 1.0 1.87478 KYSE180 CCLE Cell Line Gene CNV Profiles 1.0 1.72854 Perturb_11549_KD_hNRNPK_SRP362515 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE235701,GSE261434_0_v_3_enasidenib_human RummaGEO Drug Perturbation Signatures -1.0 null ABC1 CCLE Cell Line Gene CNV Profiles 1.0 1.46151 dorsal thalamus_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.35814 amino acid metabolic disorder DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null abnormality of the musculature HPO Gene-Disease Associations 1.0 null HIST1H2BH Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Diseases of metabolism Reactome Pathways 2024 1.0 null GSE101527_0_v_1_smad4_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K84423439 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8401 KYSE140 CCLE Cell Line Gene CNV Profiles 1.0 2.63619 15656903-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null Temporal gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.449 496100519_HIP_probable Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.08304 BRD-K31716785 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.43163 CRCGN012_HEPG2_24H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.63289 SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09146 BT-474 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.37716 neuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.053606 PPP2R1B Pathway Commons Protein-Protein Interactions 1.0 null periventricular stratum of m2AD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20497 GTEX-XUJ4-1226-SM-4BOPD GTEx Tissue Sample Gene Expression Profiles 1.0 1.14525 HCC1171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.08492 HMGN3 ENCODE Transcription Factor Targets 1.0 null GTEX-VUSG-0006-SM-3GIK9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.964745 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Mitochondrion COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.653 erythroid cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.177171 H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K17553044 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78365 Perturb_17172_OE_ESR1_SRP166112 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 HOXB7-26014856-BT474-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PMC11772884-41421_2024_747_MOESM6_ESM.xlsx-7_DEGs_USF2-KO_vs_control-Gene_Symbol_USF2 Rummagene Transcription Factor Associations 2026 1.0 null ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.68686 SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17654 A-CA-04-2009(H1N1)_24Hour_None_GSE37571 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.91198 abnormality of the abdominal organs HPO Gene-Disease Associations 1.0 null BL2227 (FIGNL1) NURSA Protein Complexes 1.0 null GSE242290_3_v_11_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H1_BMP4_Derived_Mesendoderm_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.826492 BRD-K09144377 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24372 intracellular part GO Cellular Component Annotations 2015 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8518-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE126127_2_v_3_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4619-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Paraflocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21626 PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.792709 BB65-RCC Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -5.20355 NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02521 H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BHLHE40_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFG7-0526-SM-3GIKI GTEx Tissue Sample Gene Expression Profiles 1.0 1.30202 lower GeneRIF Biological Term Annotations 1.0 null SR786 CCLE Cell Line Gene Expression Profiles -1.0 -2.10854 IFIT2 Pathway Commons Protein-Protein Interactions 1.0 null MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.20345 UACC-257 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.896032 GSE226114,GSE226116_2_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Polygenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.45 GSE147876,GSE147877_4_v_6_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE57397,GSE57399_1_v_0_fbxw7_human RummaGEO Gene Perturbation Signatures -1.0 null Lymphocyte count GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.969897 3 Methylcrotonyl-CoA carboxylase 1 deficiency ClinVar Gene-Phenotype Associations 1.0 null GTEX-WHPG-0006-SM-3NMBV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31106 HCC78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K82504878 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22799 PMC4609150-13073_2015_228_MOESM2_ESM.xlsx-TP53-Gene_TP53 Rummagene Transcription Factor Associations 2026 1.0 null Metabolic acidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.22 RPS8 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-OIZI-1026-SM-3NB1K GTEx Tissue Sample Gene Expression Profiles 1.0 1.72969 Perturb_6075_KD_SUV39H2_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE103124_1_v_0_bmpr1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null RPS23 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-V1D1-0006-SM-3NMCE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02129 ATF2 ENCODE Transcription Factor Targets 1.0 null water-soluble vitamin metabolic process GO Biological Process Annotations 2015 1.0 null GSE195786_0_v_1_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null RAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.2769 CAPZA1 Pathway Commons Protein-Protein Interactions 1.0 null SKBR3 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.921538 TFAP2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.1921 Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.821 H2AFJ Pathway Commons Protein-Protein Interactions 1.0 null NCIH1435 CCLE Cell Line Gene CNV Profiles -1.0 -1.77322 Lung adenocarcinoma_LUAD_TCGA-78-8640-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.19632 YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE48812_2_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GSE158197_0_v_4_egfr_mouse RummaGEO Gene Perturbation Signatures 1.0 null Other source TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.333 Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.583 reuniens nucleus (medioventral nucleus) of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.52721 NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.90274 USF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DGUOK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49457 GSE184356_1_v_2_tfam_human RummaGEO Gene Perturbation Signatures -1.0 null GSE82110,GSE82299_1_v_0_acriflavine_human RummaGEO Drug Perturbation Signatures 1.0 null EP300_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null (E)-2-Methylglutaconic acid HMDB Metabolites of Enzymes 1.0 null H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K27384243 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.42657 RPH3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35811 PMC4590705-13062_2015_86_MOESM1_ESM.xlsx-Gene_A_-_TP53-Unnamed_8_TP53 Rummagene Transcription Factor Associations 2026 1.0 null IGROV1 BioGPS Cell Line Gene Expression Profiles -1.0 -0.902057 Sarcoma_SARC_TCGA-Z4-A9VC-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.064 CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K52123365 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18442 GSE137325_2_v_0_copanlisib_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17338 496100277_FWM_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.21612 RFX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.9595 HDAC2 ENCODE Transcription Factor Targets 1.0 null GTEX-POYW-0006-SM-2XCF4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03701 Mitochondrial crista junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.628 EP300_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null nih 3T3 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.979389 foxa2_20483781_p15_lung_lof_mouse_gpl1261_gse19204 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.574316 leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063388 CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null P granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.622 cerebellar cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.942069 GSE91015_0_v_1_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null ELP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00673 r9 part of the lateral reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.63254 HIST1H2BO Pathway Commons Protein-Protein Interactions 1.0 null FOXA1_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4489_KO_Rnu11/Trp53_SRP309496 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.44967 cytoplasm COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 mcca GeneRIF Biological Term Annotations 1.0 null IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.86059 8661_TAF1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.586496 GSE171292_6_v_0_ehhadh_mouse RummaGEO Gene Perturbation Signatures -1.0 null LMO2-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K36204977 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.66286 SNU503 CCLE Cell Line Gene CNV Profiles 1.0 1.70202 Piriform area, polymorph layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18425 POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRP9 Pathway Commons Protein-Protein Interactions 1.0 null pt-k2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.810638 Pancreatic adenocarcinoma_PAAD_TCGA-F2-6880-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null MCF7_Veliparib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0159764 H3K9ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE171352_2_v_3_glucagon_human RummaGEO Drug Perturbation Signatures 1.0 null GC-04-UF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.430525 GSE239844_4_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.77396 medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.89464 GSE199255,GSE199356_4_v_5_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.467306 digestive juice TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.298883 Movement disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.67 GSE226285_3_v_0_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null Nr1h3::Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.9204 H3K79me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE227698_2_v_1_g0s2_human RummaGEO Gene Perturbation Signatures 1.0 null primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.909924 GSE140937,GSE140938_0_v_2_slfn11_human RummaGEO Gene Perturbation Signatures -1.0 null Carcinoma, Hepatocellular CTD Gene-Disease Associations 1.0 1.41063 CHD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null cystadenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.347511 Failure To Thrive In Infancy DisGeNET Gene-Phenotype Associations 1.0 null RPL4 Pathway Commons Protein-Protein Interactions 1.0 null SNU899 CCLE Cell Line Gene CNV Profiles 1.0 1.34076 BRD-K93374700 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31089 SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.3855 MCF7_Epothilone A_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0139733 CHD4 ENCODE Transcription Factor Targets 1.0 null H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AG-0226-SM-2S1P4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21358 H3K79me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NFIC JASPAR Predicted Transcription Factor Targets 1.0 null SNU-423 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.896032 BRD-K36168475 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08086 SW-620 cell ProteomicsDB Cell Type and Tissue Protein Expression Profiles -1.0 -1.46635 H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null TCF7L2 ENCODE Transcription Factor Targets 1.0 null LC-1-SQ COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 RPL36AL Pathway Commons Protein-Protein Interactions 1.0 null ZSCAN5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17607 medial part of r8B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25508 DCTN1 Pathway Commons Protein-Protein Interactions 1.0 null Lung-type ii pneumocyte Tabula Sapiens Gene-Cell Associations 1.0 14.1112 POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterodorsal nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.893168 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table2_ChinaMAP_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null CAPZB Pathway Commons Protein-Protein Interactions 1.0 null cyst TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.21883 GSE190316,GSE190324_10_v_9_rbm4_human RummaGEO Gene Perturbation Signatures 1.0 null organelle GO Cellular Component Annotations 2015 1.0 null PMC9046280-41467_2022_29963_MOESM5_ESM.xlsx-ASCL1_motif-Gene_Name_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null A549_Ruxolitinib_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0119795 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null r3 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03714 CRCGN015_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.82935 biotin carboxylase activity GO Molecular Function Annotations 2025 1.0 null Regio parietalis capitis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.221 mantle zone of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65371 HOXB4-20404135-EML-MOUSE ChEA Transcription Factor Targets 2022 1.0 null USF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null t69-brown-adipose_consensus MoTrPAC Rat Endurance Exercise Training 1.0 2.98768 TKT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43501 IZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.63418 GSE172020_0_v_2_testosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null dorsal cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28478 BRD-K37387086 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3851 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.836 Nucleus of the lateral olfactory tract, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05852 USF1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null EFO21 CCLE Cell Line Gene CNV Profiles 1.0 1.50437 HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.1088 MEF2D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7846 liver HPA Tissue Gene Expression Profiles 1.0 0.862415 Lymphoma_burkitts(Daudi) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.29663 H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K00685640 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25438 K562_PF-573228_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0162137 WHSC1 ENCODE Transcription Factor Targets 1.0 null cerebellar cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.84215 BRD-K80348542_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Plasmodium falciparum malaria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.192 shoot TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05605 posteroventral (inferior) parietal cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.936483 BRD-K28216304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02489 RPS9 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SN12C COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC11166884-mmc4.xlsx-Table_S3-Table_S3_proinflammatory-EC2_comparison_between_WT_and_TG_TCF15 Rummagene Transcription Factor Associations 2026 1.0 null biological_process GO Biological Process Annotations 2015 1.0 null cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.13537 H3K27ac_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null JDP2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.293 USF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN011_HEPG2_24H:I19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5138 USF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX Rummagene Transcription Factor Associations 2026 1.0 null Left atrium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.516 Brain - Cerebellum GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.766904 ZNF263 ENCODE Transcription Factor Targets 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-KV-A74V-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MXI1 ENCODE Transcription Factor Targets 1.0 null Rumen epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.727 GTEX-WCDI-0002-SM-3P61U GTEx Tissue Sample Gene Expression Profiles 1.0 1.09434 GTEX-OHPL-0426-SM-3TW8X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.91419 GTEX-R45C-0926-SM-3GAD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841583 Methylcrotonyl-Coa Carboxylase Deficiency DisGeNET Gene-Disease Associations 1.0 null Perturb_17179_OE_ESR1_SRP166112 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSK3A_knockdown_205_GDS4305 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.50494 intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE224004,GSE224005_0_v_1_chd4_human RummaGEO Gene Perturbation Signatures 1.0 null 15735024-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NIHOVCAR3 DepMap CRISPR Gene Dependency 1.0 2.03789 GSE151612_0_v_3_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table6_gnomAD_EUR_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K74568352 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50387 PMC11892598-pnas.2417308122.sd05.xlsx-DEGs_of_RORC_cluster-Unnamed_3_RORC Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null gall bladder TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.172198 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Neurobehavioral Manifestations CTD Gene-Disease Associations 1.0 1.22306 H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null oxoacid metabolic process GO Biological Process Annotations 2015 1.0 null Nerve ring TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.517 Prostate adenocarcinoma_PRAD_TCGA-CH-5754-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.29206 GSE199255,GSE199356_3_v_2_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S7SF-0006-SM-3K2B6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25545 GTEX-RWS6-0926-SM-47JXE GTEx Tissue Sample Gene Expression Profiles 1.0 2.17143 BRD-K90151990 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.081 BRD-K05151076_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Deuterosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.852 TOMM40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1224 GSE215351,GSE215794_2_v_3_kdm8_mouse RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MET_knockout_256_GSE25583 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.72979 bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.205774 organic acid metabolic process GO Biological Process Annotations 2015 1.0 null BRD-A40022950 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03554 telencephalon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.075606 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Occipital lobe TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.264 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EO-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PAX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Huelle cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.746 POU2F2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.21863 Prostate adenocarcinoma_PRAD_TCGA-YL-A8S8-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LRRN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64351 ATF3 ENCODE Transcription Factor Targets 1.0 null RPAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37712 Anteromedial visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.56339 Abnormalities, Drug-Induced CTD Gene-Disease Associations 1.0 1.5186 CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNRNPH2 Pathway Commons Protein-Protein Interactions 1.0 null GSE227415_1_v_0_ucp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.035275 IGF2BP1 Pathway Commons Protein-Protein Interactions 1.0 null toxin-antitoxin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.111 CRCGN013_HEPG2_24H:K04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.96421 GSE160817_0_v_6_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81I-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QLQW-0226-SM-447BJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.10916 TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3079 Uterine Carcinosarcoma_UCS_TCGA-ND-A4WA-01A-12R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE219274,GSE219276_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE158431_2_v_6_pioglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null SIN3A_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MSANTD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1437 Perturb_12647_KD_Dirc3_SRP191022 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 DU-145 COSMIC Cell Line Gene Mutation Profiles 1.0 null USF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K70428675 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88103 SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JURKAT, CLONE E6-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null abnormality of brain morphology HPO Gene-Disease Associations 1.0 null Autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.923 Perturb_15184_KD_SREBP_SRP190161 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.67326 GSE241036_4_v_2_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.73492 GTEX-XBED-0126-SM-47JY7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01846 Combined malonic and methylmalonic acidemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.93 embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.45135 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null organic substance metabolic process GO Biological Process Annotations 2015 1.0 null GSE229468,GSE229471_0_v_3_znf587_human RummaGEO Gene Perturbation Signatures -1.0 null 2988_FBL_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.531335 K562_PF-573228_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0199328 H3K79me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.216 CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.844259 SKHEP1 CCLE Cell Line Gene CNV Profiles -1.0 -1.45627 dorsal motor nucleus of the vagus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.91391 RPL19 Pathway Commons Protein-Protein Interactions 1.0 null 8856_TFR2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.525288 MCF7_Cediranib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141511 mitochondrial inner membrane GO Cellular Component Annotations 2015 1.0 null GSE156454_0_v_1_tamoxifen_human RummaGEO Drug Perturbation Signatures -1.0 null phenotype GeneRIF Biological Term Annotations 1.0 null BRD-K79678951 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40818 GSE157594_6_v_2_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K13696195 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24465 Sickle cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.293 CRCGN015_HEPG2_48H:A09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06612 ARPC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69862 H2BK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5232 Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Reactome Pathways 2014 1.0 null RPS10 Pathway Commons Protein-Protein Interactions 1.0 null GSE109565_12_v_11_glyphosate_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN013_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4241 MCF7_ENMD-2076 L-Tartaric acid_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0200419 PMC11953091-12035_2025_4695_MOESM1_ESM.xlsx-s5-Supplementary_Table_5_Results_of_the_2-sample_pQTL_MR_on_insomnia_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-A24643465_homoharringtonine_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K07736136_S6005_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lymphoblast TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.519 GTEX-OXRK-0926-SM-2HMKP GTEx Tissue Sample Gene Expression Profiles 1.0 1.07694 GSE134375_0_v_5_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K67188562 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39449 DU 145 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Hepatitis DisGeNET Gene-Disease Associations 1.0 null ventral tuberomammillary nucleus, intermediate part (histaminergic) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25918 CRCGN016_MCF10A.TP53.M_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.29518 Infertility, Male CTD Gene-Disease Associations 1.0 1.18587 NFIC_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K72435943 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.99559 hsa-miR-193b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 NFYA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null A549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.22793 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_407_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null EN COSMIC Cell Line Gene Mutation Profiles 1.0 null Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.826 GTEX-Q2AH-0326-SM-48U1K GTEx Tissue Sample Gene Expression Profiles -1.0 -0.894128 GSE88819_0_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.06689 Neoplasms CTD Gene-Disease Associations 1.0 1.42508 BRD-K28079391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0791 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Liver Cirrhosis, Experimental CTD Gene-Disease Associations 1.0 1.02671 Prostate adenocarcinoma_PRAD_TCGA-YL-A9WJ-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EBF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE147876,GSE147877_4_v_5_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.889202 SREBF1 JASPAR Predicted Transcription Factor Targets 1.0 null Parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.90929 H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TFAP2C-20629094-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE213588_10_v_3_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null mantle zone of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58698 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6997-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.957195 H3K27ac_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null A-431 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.965412 KRT85 Pathway Commons Protein-Protein Interactions 1.0 null ZNF90 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14798 PGC-1alpha_Deficiency_GDS4904_310_mouse_Aged gastrocnemius muscle - 10 weeks GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.03712 PE/CA-PJ15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06035 Testis GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.695998 blood cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057808 HCC70 DepMap CRISPR Gene Dependency 1.0 8.25898 Perturb_13920_KD_HNRNPK_SRP312616 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 RELA_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null central nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057744 family GeneRIF Biological Term Annotations 1.0 null TFAP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.9034 GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42213 POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ligase activity GO Molecular Function Annotations 2015 1.0 null NDUFA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69335 GTEX-SUCS-0526-SM-4DM56 GTEx Tissue Sample Gene Expression Profiles 1.0 1.49361 leaf TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060123 K562_Cediranib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0153385 BRD-A25170757_1-(4,5-bis(benzyloxy)-2-fluorophenyl)-2-(methylamino)ethanol KLK-33_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PML ENCODE Transcription Factor Targets 1.0 null SPI1-23547873-NB4-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K21997380 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.60971 DU4475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03933 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3328-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE201309_5_v_3_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null TCF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.3125 CRCGN011_HEPG2_24H:E08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.28275 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAPAN-1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.24184 amygdaloid complex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.27366 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SN8G-0001-SM-3NM8L GTEx Tissue Sample Gene Expression Profiles 1.0 1.03875 H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Disulfiram_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0183261 DYNC1H1 Pathway Commons Protein-Protein Interactions 1.0 null USF1_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bipolar disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.279 hyperreflexia HPO Gene-Disease Associations 1.0 null GSE102269_1_v_2_clpp_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE157594_5_v_7_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.986434 cerebellar cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.955224 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-361-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 lower dorsal perifornical nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.81314 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TI-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of central motor function HPO Gene-Disease Associations 1.0 null USB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16461 GaMG cell ProteomicsDB Cell Type and Tissue Protein Expression Profiles 1.0 0.847463 BRD-K14327064 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09526 H3K27ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 3-Methylcrotonyl-CoA HMDB Metabolites of Enzymes 1.0 null urinary system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.070506 SNAI2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.8949 CRCGN016_MCF10A.WT.HP_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.9284 hsa-miR-4644 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 BRD-K31147195 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14347 Mesothelioma_MESO_TCGA-TS-A7P8-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.12695 GTEX-S3XE-1026-SM-4AD4O GTEx Tissue Sample Gene Expression Profiles 1.0 1.16267 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormality of nitrogen compound homeostasis HPO Gene-Disease Associations 1.0 null SCLC-22H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.30289 HCC15 CCLE Cell Line Gene CNV Profiles -1.0 -1.66802 GTEX-T8EM-0006-SM-3DB71 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09124 amygdaloid complex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02385 GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.93257 H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE146074_9_v_7_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-U8XE-0005-SM-3DB8I GTEx Tissue Sample Gene Expression Profiles -1.0 -0.925047 H3K79me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TUBA1B Pathway Commons Protein-Protein Interactions 1.0 null GTEX-P78B-1326-SM-3P611 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14435 GSE215086_1_v_6_batf_human RummaGEO Gene Perturbation Signatures 1.0 null MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K69074358 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48556 RPS4X Pathway Commons Protein-Protein Interactions 1.0 null UMUC1 DepMap CRISPR Gene Dependency 1.0 2.01669 GTEX-PLZ5-0726-SM-2I5F9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.3651 BRD-K58382884 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07879 GSE142588_2_v_1_cinobufagin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE217452_3_v_1_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K86002795 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84857 SARS-CoV MA15_Day4_None_GSE49262 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.16534 GSE193402_0_v_2_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null germ layer TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.070126 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE169152_3_v_2_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null anterior tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1176 GSE178532_2_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE142430_3_v_1_prmt5_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.842952 CUL4B Pathway Commons Protein-Protein Interactions 1.0 null CI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.990283 TEAD4_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MZ1-PC Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.9496 monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.454093 AM-38 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.90637 BRD-K03221986 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11852 Muscular disease DISEASES Curated Gene-Disease Association Evidence Scores 2025 1.0 5.0 MZ in rostral midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14804 primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.25925 ATP-grasp fold, subdomain 1 InterPro Predicted Protein Domain Annotations 1.0 null H3K4me3_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE128634,GSE128636_1_v_3_foxo1_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN016_MCF10A.TP53.M_24H:B22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.41785 Acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.264 H2BK12ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K53634892 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74108 Liver Neoplasms CTD Gene-Disease Associations 1.0 1.55084 POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.973546 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-CS-6186-01A-12R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.53602 Kna TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.777 PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3 Rummagene Transcription Factor Associations 2026 1.0 null PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A71E-01A-31R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.300311 Neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.871 TFAP2C ChEA Transcription Factor Targets 1.0 null POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KRT32 Pathway Commons Protein-Protein Interactions 1.0 null IGROV-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.952253 GTEX-POYW-1126-SM-48TCI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824089 Biotin metabolism including IMDs WikiPathways Pathways 2024 1.0 null GSE114258_1_v_2_foxk1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Intracellular organelle lumen COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 KYSE-140 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 6493_PNO1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.570067 ATF3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE144231_3_v_5_cxcr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null GTEX-PLZ5-0006-SM-2S1NZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09428 SPI1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135030_3_v_2_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE223241_1_v_3_cdkn2a_human RummaGEO Gene Perturbation Signatures -1.0 null adrenal gland GTEx Tissue Gene Expression Profiles 1.0 1.32988 GTEX-POMQ-0006-SM-33HBY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32445 RPS7 Pathway Commons Protein-Protein Interactions 1.0 null reports GeneRIF Biological Term Annotations 1.0 null GSE171177,GSE171181_1_v_0_e7107_human RummaGEO Drug Perturbation Signatures -1.0 null DHX9 Pathway Commons Protein-Protein Interactions 1.0 null SAP130 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11434 BRD-K78195641 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01562 water-soluble vitamin metabolic process GO Biological Process Annotations 2023 1.0 null TP53 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.6928 Hippocampus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 BRD-K51196703 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.74801 GSE178714_6_v_7_smad2_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K82818427_Chemistry 1735_AGS_6.0_h_44.4_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null single-organism cellular process GO Biological Process Annotations 2015 1.0 null BRD-K67200393 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19194 Paraflocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33686 H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lewy body TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.283 K562_Clevudine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0164218 Aorta TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 skbr3 HPA Cell Line Gene Expression Profiles 1.0 1.48351 RPL3 Pathway Commons Protein-Protein Interactions 1.0 null OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.70408 Perturb_1420_OE_Aatf_SRP257744 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.11434 GSE111247_11_v_13_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PWN1-2426-SM-48TDD GTEx Tissue Sample Gene Expression Profiles 1.0 0.87551 HIST1H2BD Pathway Commons Protein-Protein Interactions 1.0 null RNF2 Pathway Commons Protein-Protein Interactions 1.0 null EGR1 ENCODE Transcription Factor Targets 1.0 null GTEX-TMMY-1626-SM-4DXTY GTEx Tissue Sample Gene Expression Profiles 1.0 2.46046 Parkinsonism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.537 H3K9ac_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S16_LF_C2_8h-Unnamed_5_LTF Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WHSB-0005-SM-3LK7C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64026 GSK3B_knockdown_158_GSE35351 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.74814 posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.48025 all GWASdb SNP-Phenotype Associations 1.0 0.035285 H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.80813 cerebral hemisphere TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.079435 adenyl ribonucleotide binding GO Molecular Function Annotations 2015 1.0 null hippocampus (hippocampal formation)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.32248 BRD-K06935782 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32623 dorsal spiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03087 r5 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04509 Fibre tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.245 mitochondrial crista COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.533719 JUND ENCODE Transcription Factor Targets 1.0 null Whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 LMO2 ChEA Transcription Factor Targets 1.0 null EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07453 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.816 RAD21 ENCODE Transcription Factor Targets 1.0 null H3K4me1_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Amino acid metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.336 GSE77108_4_v_7_saha_human RummaGEO Drug Perturbation Signatures -1.0 null RPL7 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 496100596_FWM_dementia_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.88896 K562_PD98059_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0207439 Piriform-amygdalar area, polymorph layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01822 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Duodenum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.099307 periventricular stratum of m1AD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2294 CRCGN013_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.71805 HIST2H2AA4 Pathway Commons Protein-Protein Interactions 1.0 null Gravid adult TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.747 POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-668 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11083 TT CCLE Cell Line Gene CNV Profiles 1.0 1.42932 BRD-K38431962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70119 TAF1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRDX4 Pathway Commons Protein-Protein Interactions 1.0 null Methylmalonic acidemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.892 abnormality of extrapyramidal motor function GWASdb SNP-Phenotype Associations 1.0 1.40061 MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ccnd1_18413728_imr_neuroblastoma_lof_human_gpl570_gse8866 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -1.0304 orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.40671 Biotin DrugBank Drug Targets 1.0 null EE-98-PF86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.230638 SDF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31776 organelle inner membrane GO Cellular Component Annotations 2015 1.0 null KYSE-70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.2479 Hyperammonemia DisGeNET Gene-Phenotype Associations 1.0 null JUND_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00017 amygdaloid complex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.26652 Organic Aciduria DisGeNET Gene-Phenotype Associations 1.0 null superficial stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.89785 GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63631 gracile nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02889 POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7526_RPS4X_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.51118 Diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.225 FOSL2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SH10TC CCLE Cell Line Gene Expression Profiles -1.0 -1.65009 RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE226316_11_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null HCT-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-TKQ2-0226-SM-4DM6V GTEx Tissue Sample Gene Expression Profiles 1.0 2.06893 acidosis HPO Gene-Disease Associations 1.0 null HUES64_Cell_Line Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.46604 orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.69924 Perturb_10312_OE_hAPOL1_G1_SRP075245 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 hypertonia HPO Gene-Disease Associations 1.0 null H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null branched-chain amino acid catabolic process GO Biological Process Annotations 2025 1.0 null BRD-K81206010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24701 GSE157777_2_v_3_foxa3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Nonsyndromic deafness DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.059 ZR75_1 BioGPS Cell Line Gene Expression Profiles 1.0 2.41001 Dihydrolipoyl dehydrogenase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.177 ALDH4A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15824 BRD-K25952063 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19287 Holocarboxylase synthetase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.437 USF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE88819_6_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null 1040_C1ORF131_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.501761 E2F1-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SOCS3_KO_GDS3149_297_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.472 GSE165122_2_v_3_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE80098,GSE80366_0_v_8_progesterone_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PWCY-1926-SM-3NB25 GTEx Tissue Sample Gene Expression Profiles 1.0 1.51415 AKAP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10766 SARS-CoV MA15_Day4-C57BL6_None_GSE51386 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.8798 Digenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.413 2526_EIF1AD_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.545601 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.06498 Gestational trophoblastic neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.107 AD-16-HL96_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.271921 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.209169 Lung Neoplasms CTD Gene-Disease Associations 1.0 1.28241 GSE125403_7_v_6_venetoclax_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K45589340 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58584 FOXM1-26456572-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null analyses GeneRIF Biological Term Annotations 1.0 null BRD-K22137463 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36891 GSE224599_0_v_1_tfcp2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-U8XE-1226-SM-4E3HN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.928289 GTEX-S33H-0005-SM-2XCAL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06967 7566_RRP7A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.678645 GSE125403_3_v_0_venetoclax_human RummaGEO Drug Perturbation Signatures 1.0 null PC Pathway Commons Protein-Protein Interactions 1.0 null intermediate stratum of APal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.60208 GSE205163,GSE205164_3_v_6_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE215849_2_v_1_muc1_human RummaGEO Gene Perturbation Signatures 1.0 null K562_A-366_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149927 Brain Lower Grade Glioma_LGG_TCGA-DU-8161-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFIB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.5403 POLR2A_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL13A Pathway Commons Protein-Protein Interactions 1.0 null GSE116894_1_v_0_tle3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_8361_KD_STAT3_SRP372295 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 16.305 REST_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ASCL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 79.1758 GSE164726_0_v_1_phf10_human RummaGEO Gene Perturbation Signatures 1.0 null GSE168401_2_v_0_harmine_human RummaGEO Drug Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-J1-A4AH-01A-31R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null five GeneRIF Biological Term Annotations 1.0 null KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19301 9505BIK DepMap CRISPR Gene Dependency 1.0 2.29898 PB-09-OE00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.247629 MBD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A27422067 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78134 Abnormalities, Multiple CTD Gene-Disease Associations 1.0 1.15425 GTEX-SUCS-0626-SM-32PM5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.77852 retina BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.985109 M059K DepMap CRISPR Gene Dependency 1.0 3.77437 CERS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00362 H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OXRK-0326-SM-3NB3R GTEx Tissue Sample Gene Expression Profiles 1.0 0.835014 PMC12209767-bcd-25-0099_supplementary_table_s2_suppst2.xlsx-C_DEGs_RNA-seq-Supplementary_table_S2C_List_of_differentially_expressed_genes_in_IGHUND_vs_IGH_GCB_MB2_DE_DLBCL_HGBCL-DH-BCL2_-BCL6_BCL6 Rummagene Transcription Factor Associations 2026 1.0 null PRPF31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93452 abducens nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.48516 BRD-K43284834 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07578 TE10 CCLE Cell Line Gene Expression Profiles 1.0 2.52379 BRD-K21544408 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25384 CAMA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.23371 primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.891182 GSE139975_3_v_0_rnf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Muscular Dystrophy_Muscle - Striated (Skeletal) - Diaphragm (MMHCC)_GSE3252 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.3854 EP300_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZN-2626-SM-3DB7T GTEx Tissue Sample Gene Expression Profiles 1.0 0.840873 layer I of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.967875 DYNC2H1 Pathway Commons Protein-Protein Interactions 1.0 null RPS3A Pathway Commons Protein-Protein Interactions 1.0 null CRCGN015_MCF10A.TP53.M_24H:F17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1519 RPS24 Pathway Commons Protein-Protein Interactions 1.0 null JL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.01163 NCI-H2122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.985368 BRD-K37900095 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30507 GSE239844_8_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null dorsal part of m2A Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20198 Perturb_17195_OE_HER2_SRP166112 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BRD-K52973286 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36389 SGOL2 Pathway Commons Protein-Protein Interactions 1.0 null GSE145323,GSE145324_3_v_2_rfx3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Myosin XI complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.504 GTEX-XQ8I-2026-SM-4BOOL GTEx Tissue Sample Gene Expression Profiles 1.0 0.854317 GTEX-WZTO-0006-SM-3NM9T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33807 Cortical amygdalar area, anterior part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.53236 GSE160817_2_v_8_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null chemdependency GAD High Level Gene-Disease Associations 1.0 0.293278 RPSA Pathway Commons Protein-Protein Interactions 1.0 null clinical GeneRIF Biological Term Annotations 1.0 null Trophoblastic neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.066 GSE63048_11_v_6_morc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-515-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 Failure To Thrive DisGeNET Gene-Disease Associations 1.0 null HNRNPC Pathway Commons Protein-Protein Interactions 1.0 null DB CCLE Cell Line Gene CNV Profiles -1.0 -1.77972 BRD-K59434830 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40408 SRSF7_02_89 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59626 PMC12271601-mmc2.xlsx-OUT_cells_01-Gene_Symbol_TCF23 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62419 intermediate stratum of PPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02476 Endopiriform nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.76416 GSE229973_4_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null MCF7_Abexinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00782733 H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCIH650 CCLE Cell Line Gene CNV Profiles -1.0 -2.54336 hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.342 S100A9 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_3390_KO_Utx_SRP242086 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.03033 macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.332848 Prostatic Diseases CTD Gene-Disease Associations 1.0 1.24781 GTEX-REY6-0005-SM-2TF54 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18781 CTBP2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Heart Defects, Congenital CTD Gene-Disease Associations 1.0 1.23137 CRCGN016_MCF10A.WT.HP_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.47104 PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table4_gnomAD_EAS_GCR-SYMBOL_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN012_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.65869 amygdaloid complex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.85213 TUBB4B Pathway Commons Protein-Protein Interactions 1.0 null OVCAR5 BioGPS Cell Line Gene Expression Profiles 1.0 1.01059 coa carboxylase activity GO Molecular Function Annotations 2015 1.0 null appendices_4b HPA Tissue Sample Gene Expression Profiles -1.0 -1.08255 primary metabolic process GO Biological Process Annotations 2015 1.0 null seed TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057284 GTEX-WEY5-0001-SM-3P61Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.54791 Feeding Difficulties In Infancy DisGeNET Gene-Phenotype Associations 1.0 null BRD-K65127260 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.37458 r7 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26535 HNRNPL Pathway Commons Protein-Protein Interactions 1.0 null Nephrolithiasis_Kidney_GSE10162 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.49776 H3K27ac_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-T5JC-0001-SM-3NMAK GTEx Tissue Sample Gene Expression Profiles 1.0 1.12405 GSE77108_0_v_1_saha_human RummaGEO Drug Perturbation Signatures 1.0 null ISX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.7653 abnormality of the urinary system HPO Gene-Disease Associations 1.0 null parkinson's disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.682635 abnormality of urine homeostasis HPO Gene-Disease Associations 1.0 null kidney HPA Tissue Gene Expression Profiles 1.0 1.77733 dorsal thalamus_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.36435 TAL1_megakaryocyte_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tauopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.345 HDAC1 ENCODE Transcription Factor Targets 1.0 null HCFC1 ENCODE Transcription Factor Targets 1.0 null BRD-K90048234 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14471 GSE143462_0_v_1_omipalisib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE235066_4_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GSE195568_2_v_10_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null TrigeminalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.986406 MCF7_Vandetanib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0128343 BRD-K09376136 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35419 PRRX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.035 MAX ENCODE Transcription Factor Targets 1.0 null medial habenular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.873203 GSE125782_0_v_1_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null HLE GDSC Cell Line Gene Expression Profiles -1.0 -1.52823 aorta TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HCC-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null EP300_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K42061172 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10842 NCI-H650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.61089 Urinary system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 liver TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059829 GTEX-RNOR-0005-SM-2TF4Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10688 nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04468 15260889-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null GSE183606_1_v_0_rutaecarpine_human RummaGEO Drug Perturbation Signatures 1.0 null 15897907-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null MCF7_Prednisone_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0216242 MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KARPAS-422 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.842952 SCN4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09399 FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_7784_KD_BS692_SRP030639 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7261-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K92640680 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51413 GSE98898_8_v_1_hoxa1_human RummaGEO Gene Perturbation Signatures -1.0 null SNU626 DepMap CRISPR Gene Dependency 1.0 2.01062 CRCGN015_HEPG2_48H:P22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.97577 Inflammation CTD Gene-Disease Associations 1.0 1.72926 H3K4me1_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null UACC62_SKIN CCLE Cell Line Proteomics 1.0 4.49851 GSE221327_1_v_9_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null biotin binding GO Molecular Function Annotations 2015 1.0 null phenotypic abnormality HPO Gene-Disease Associations 1.0 null M14 BioGPS Cell Line Gene Expression Profiles 1.0 1.02475 H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4329-01A-02R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pallidum, dorsal region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.95082 CCT8 Pathway Commons Protein-Protein Interactions 1.0 null striatum_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.5806 CRCGN013_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.92668 GSE130715_1_v_0_budesonide_human RummaGEO Drug Perturbation Signatures -1.0 null HIST1H2BL Pathway Commons Protein-Protein Interactions 1.0 null GSE226285_3_v_1_nr0b1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE160817_0_v_8_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null cerebellum BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.48073 VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.16227 CRCGN012_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.98828 GTEX-N7MS-0007-SM-2D7W1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30293 TOE1 Pathway Commons Protein-Protein Interactions 1.0 null HNF4A Pathway Commons Protein-Protein Interactions 1.0 null 19356222-SuppTable5 GeneSigDB Published Gene Signatures 1.0 null BRD-K57096799 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58701 RERF-GC-1B COSMIC Cell Line Gene Mutation Profiles 1.0 null YY1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WOFM-0005-SM-3MJF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67432 GTEX-WRHU-0006-SM-3MJF6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858062 skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles -1.0 -0.831346 CRCGN008_HEPG2_24H:L16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.66515 H3K4me1_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null PMC7906601-elife-62470-supp4.xlsx-Table_S7_MS_and_siRNA_KD-Supplementary_File_4_Summary_of_HIV-1_splice_variant_interactome_MS_data_and_siRNA_KD_expression_changes_data_Related_to_Figures_2_and_3_AR Rummagene Transcription Factor Associations 2026 1.0 null K562_Ki8751_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137951 ESR1-26153859-T47D-HUMAN-BREAST-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null disease DISEASES Curated Gene-Disease Association Evidence Scores 1.0 null K562_Capecitabine_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0179284 RPLP2 Pathway Commons Protein-Protein Interactions 1.0 null TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YWHAE Pathway Commons Protein-Protein Interactions 1.0 null Perturb_2889_KO_Mcrip2_SRP302058 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -15.2368 H3K4me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Propionic acidemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.513 supragenual nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1195 Cognitive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.723 GTEX-TMMY-0126-SM-4DXTP GTEx Tissue Sample Gene Expression Profiles 1.0 1.47588 forebrain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.067529 GTEX-QLQW-0726-SM-447AA GTEx Tissue Sample Gene Expression Profiles 1.0 0.964212 ENO1 Pathway Commons Protein-Protein Interactions 1.0 null NEDD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19907 coa GeneRIF Biological Term Annotations 1.0 null ASPC1 CCLE Cell Line Gene Expression Profiles -1.0 -1.73321 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7477_RPL7A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.578366 GSE144347_1_v_0_crnkl1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WHWD-0005-SM-3LK7D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38374 GTEX-XUJ4-0126-SM-4BOP7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.1119 HDAC6 ENCODE Transcription Factor Targets 1.0 null cytoplasmic part GO Cellular Component Annotations 2015 1.0 null Globus pallidus, internal segment Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28762 BRD-K14823121 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27615 HCC1359 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.37241 TFAP2A-35110662-HEPM-HUMAN-EMBRYO ChEA Transcription Factor Targets 2022 1.0 null CRCGN008_HEPG2_24H:O15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.03525 H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormal respiratory system morphology HPO Gene-Disease Associations 1.0 null GTEX-X4LF-0006-SM-3NMCO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1454 GSE92965_0_v_1_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE160817_3_v_9_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null renal cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.226155 GSE125211_0_v_1_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null skeletal muscle TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC7617064-EMS151900-supplement-Extended_Data_Figure_5_Source_Data.xlsx-CLC_D9_DEG-Logfold_change_threshold_1_0_1_CENPX Rummagene Transcription Factor Associations 2026 1.0 null Branched-chain amino acid catabolism Reactome Pathways 2014 1.0 null TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null supraoptic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.43466 Defects in biotin (Btn) metabolism Reactome Pathways 2024 1.0 null Perireunensis nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11656 496100484_FWM_no dementia_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.47347 GTEX-WY7C-0426-SM-3NB3C GTEx Tissue Sample Gene Expression Profiles 1.0 1.00271 RL7 BioGPS Cell Line Gene Expression Profiles 1.0 0.850519 Perturb_7042_KO_miR17/miR20a/miR18a_SRP050491 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.33868 hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.68623 GSE148657_2_v_1_cd44_human RummaGEO Gene Perturbation Signatures 1.0 null MAX_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS-12-PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.893435 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null paracentral lobule, posterior part, right, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.34139 MDAMB436 CCLE Cell Line Gene CNV Profiles -1.0 -1.63779 GTEX-R55G-0826-SM-2TC5U GTEx Tissue Sample Gene Expression Profiles 1.0 0.995873 Succinate dehydrogenase complex (ubiquinone) COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.871 CEP170B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04892 3-methylcrotonyl-CoA carboxylase deficiency DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 3.452 EXO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35093 midbrain reticular formation, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19963 central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE180951_2_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10138 H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of r7BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.15253 GTEX-RM2N-0426-SM-2TF4T GTEx Tissue Sample Gene Expression Profiles 1.0 1.79919 GSE77108_4_v_2_saha_human RummaGEO Drug Perturbation Signatures -1.0 null GATOR2 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.84 SMARCB1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 3-Methylglutaconyl-CoA HMDB Metabolites of Enzymes 1.0 null GSE111247_11_v_3_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null basal ganglia disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.952438 H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Postcentral gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.12 PMC6061679__F1 PFOCR Pathway Figure Associations 2023 1.0 null K562_RG108_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0196161 GSE125025_2_v_3_lyl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-KD-A5QS-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KARPAS422 CCLE Cell Line Gene Expression Profiles 1.0 1.82157 NUDUL1 CCLE Cell Line Gene CNV Profiles -1.0 -2.01614 amygdaloid complex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.15127 Lung squamous cell carcinoma_LUSC_TCGA-60-2711-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H-NS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.603 HCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null MCF7_Ofloxacin_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0123366 GTEX-XV7Q-1726-SM-4BRUU GTEx Tissue Sample Gene Expression Profiles 1.0 1.95507 GSE160817_2_v_6_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null A549_Motesanib Diphosphate_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0138718 KNS-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE244710_1_v_2_srsf1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null GSE216043_11_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Heart - Left Ventricle GTEx Tissue Gene Expression Profiles 2023 1.0 2.36348 K562_A-366_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141155 DOHH-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null ASH2L-23239880-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the nervous system HPO Gene-Disease Associations 1.0 null GSE148066,GSE157787_2_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K97721960 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17069 SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCT5 Pathway Commons Protein-Protein Interactions 1.0 null GSE227592_10_v_3_adar_human RummaGEO Gene Perturbation Signatures 1.0 null Periventricular hypothalamic nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02563 GTF2B ENCODE Transcription Factor Targets 1.0 null CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal glucose homeostasis HPO Gene-Disease Associations 1.0 null RUNX3 ENCODE Transcription Factor Targets 1.0 null CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216274,GSE216292_4_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null Defects in vitamin and cofactor metabolism Reactome Pathways 2024 1.0 null H3K79me2_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-W5WG-0002-SM-3NMDN GTEx Tissue Sample Gene Expression Profiles 1.0 1.42792 17638893-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null Kidney Chromophobe_KICH_TCGA-KM-8639-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12271601-mmc2.xlsx-OUT_cells_02-Gene_Symbol_TCF23 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H4K5ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.12409 r8 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37972 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S95S-0826-SM-4B64N GTEx Tissue Sample Gene Expression Profiles 1.0 1.68978 Perturb_9880_KD_RUNX1_SRP368113 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.54923 GSE215351,GSE215794_1_v_3_kdm8_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K78866630 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30248 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Pracinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0102251 facial motor nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.30953 POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TE-5 GDSC Cell Line Gene Expression Profiles 1.0 1.73984 Developmental and epileptic encephalopathy 11 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.056 cellular process GO Biological Process Annotations 2015 1.0 null cellular amino acid metabolic process GO Biological Process Annotations 2015 1.0 null MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.19303 H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QESD-0006-SM-2I5G6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74934 Perturb_16937_KO_An_SRP287147 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.26338 GTEX-O5YW-0526-SM-2YUMX GTEx Tissue Sample Gene Expression Profiles 1.0 1.27933 H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFATC1 ENCODE Transcription Factor Targets 1.0 null GSE203072_2_v_3_rpl3l_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE146687_2_v_3_eribulin_human RummaGEO Drug Perturbation Signatures -1.0 null CA-73-BW50_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.21781 clinical modifier HPO Gene-Disease Associations 1.0 null MCF7_BMS-265246_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00883281 GSE92965_0_v_1_klf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.359752 5163_MPHOSPH10_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.560913 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.510092 GSE190186,GSE190188_8_v_5_apoe_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_8364_KD_STAT3_SRP411741 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 16.4002 Lateral ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 disease DISEASES Experimental Gene-Disease Association Evidence Scores 1.0 0.682635 GSE198165,GSE198166_5_v_3_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null rosette TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.28213 CRCGN012_HEPG2_24H:G02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.40351 mantle zone of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88268 NANOG-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CCND1 ChEA Transcription Factor Targets 1.0 null GSE160817_4_v_1_slamf6_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.25259 GSE140651,GSE140653_2_v_0_med1_human RummaGEO Gene Perturbation Signatures 1.0 null 1774_COPG1_P1 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 10.9399 BRD-K04426746 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.08075 hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23961 MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.889924 BRD-K79982586 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44112 H3K79me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Breast Cancer_Mammary Gland Tissue_GSE1872 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.26095 Atherosclerosis CTD Gene-Disease Associations 1.0 1.49533 CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SUCS-0002-SM-3NMAJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.31722 PMC3634825__F3 PFOCR Pathway Figure Associations 2023 1.0 null medial part of r1B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06253 GSE149075_6_v_4_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null organelle lumen COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 SNU-423 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.14921 EZH2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_BE2C_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:L07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2348 POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell part GO Cellular Component Annotations 2015 1.0 null Pseudopodium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.886 RPL30 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5581-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.03761 GSE144838_1_v_8_egfr_mouse RummaGEO Gene Perturbation Signatures 1.0 null PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K40175214_torin-1_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4172779-13048_2014_87_MOESM1_ESM.pdf-100-SLC2A4RG_SLC2A4RG Rummagene Transcription Factor Associations 2026 1.0 null TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null VDAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10059 GSE164874_5_v_14_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null medial amygdala, anteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.63121 GATA3_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142210_3_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-QCQG-0426-SM-48U29 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22345 intracellular organelle lumen GO Cellular Component Annotations 2023 1.0 null GSE231799_3_v_5_nfkbie_mouse RummaGEO Gene Perturbation Signatures 1.0 null organonitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null ABL1_mutant_24_GDS4046 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.15537 RPL23A Pathway Commons Protein-Protein Interactions 1.0 null S100A8 Pathway Commons Protein-Protein Interactions 1.0 null globose nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13724 hsa-miR-2115 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 CRCGN015_MCF10A.TP53.M_24H:F22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.212 H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Divalproex Sodium_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0157435 GSE152441,GSE152442_6_v_4_folic acid_human RummaGEO Drug Perturbation Signatures -1.0 null MZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.49335 GTEX-WFON-0426-SM-3GIL4 GTEx Tissue Sample Gene Expression Profiles 1.0 2.59274 H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null paracentral lobule, posterior part, left, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00449 Liver Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.59427 EP300_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YV-0226-SM-48TBY GTEx Tissue Sample Gene Expression Profiles 1.0 2.0561 H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE77108_6_v_7_saha_human RummaGEO Drug Perturbation Signatures 1.0 null laterorostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.945522 PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null tRNA (m2G10) methyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.037 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6962-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hypercholesteremia_Hepatic Tissue_GSE3889 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.60295 CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null 1464_CDYL_P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.697271 GTEX-S4UY-0006-SM-3K2A7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.968892 POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RFX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.2028 HNRNPF Pathway Commons Protein-Protein Interactions 1.0 null COTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00415 Subjective response to lithium treatment GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.604576 E2F1 ChEA Transcription Factor Targets 1.0 null SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null feeding difficulties in infancy HPO Gene-Disease Associations 1.0 null NCIH650 CCLE Cell Line Gene Expression Profiles -1.0 -1.86026 detected GeneRIF Biological Term Annotations 1.0 null PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1 Rummagene Transcription Factor Associations 2026 1.0 null CTSZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01616 IFIT1 Pathway Commons Protein-Protein Interactions 1.0 null PMC9734180-41398_2022_2274_MOESM8_ESM.xlsx-Supplemental_Table_2-Supplemental_Table_2_Genes_regulated_by_TFEB_expression_are_altered_in_MAPT_p_R406W_brains_TFEB Rummagene Transcription Factor Associations 2026 1.0 null Seizures DisGeNET Gene-Phenotype Associations 1.0 null PRDX3 Pathway Commons Protein-Protein Interactions 1.0 null MLNR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00556292 Lysosomal storage disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.173 acute hepatic steatosis HPO Gene-Disease Associations 1.0 null NCI-H650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.59049 UBTF ENCODE Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JA-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null granular layer of caudal dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20591 containing GeneRIF Biological Term Annotations 1.0 null BL4267 (PPP2R3B) NURSA Protein Complexes 1.0 null PMC7617064-EMS151900-supplement-Figure_7_Source_Data.xlsx-HLC_D9_DEG-Logfold_change_threshold_1_0_1_CENPX Rummagene Transcription Factor Associations 2026 1.0 null SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.896032 ribonucleotide binding GO Molecular Function Annotations 2015 1.0 null H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE228017_0_v_1_parthenolide_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PLZ5-0326-SM-3P614 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01619 BL2270 (TCF12) NURSA Protein Complexes 1.0 null PASK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40829 H3K36me3_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE157894_2_v_0_cystine_human RummaGEO Drug Perturbation Signatures -1.0 null Paragigantocellular reticular nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02555 GTEX-RUSQ-0426-SM-47JWR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.981028 BRD-K46623934 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2874 Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.834 496100416_FWM_dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.09954 SOX2-21211035-LN229_GBM-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null TAF1 ENCODE Transcription Factor Targets 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3RB-01A-12R-A220-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K15047839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22318 HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFON-1726-SM-4LVMQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.858558 U-2932 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11195 ACACB Pathway Commons Protein-Protein Interactions 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QK-01B-11R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K14210122 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54433 PMC7782698-41467_2020_20367_MOESM9_ESM.xlsx-Student_s_t-test_BP1_ILK_GFP-Gene_names_DLX4 Rummagene Transcription Factor Associations 2026 1.0 null Tyrosinemia type II DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.179 GSE125014_1_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE48812_0_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null DQX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45384 GTEX-XPVG-2826-SM-4B66J GTEx Tissue Sample Gene Expression Profiles 1.0 0.849489 Homocystinuria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.19 EIF3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5872 GTEX-PLZ6-1326-SM-3NB24 GTEx Tissue Sample Gene Expression Profiles 1.0 1.61059 Death CTD Gene-Disease Associations 1.0 1.3998 BRD-A62995832 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36369 arcuate nucleus of medulla, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.03 GSE228727_2_v_1_dapagliflozin_mouse RummaGEO Drug Perturbation Signatures -1.0 null KDM4A ENCODE Transcription Factor Targets 1.0 null Leydig cell_Fetal gonad_Human CellMarker Gene-Cell Type Associations 1.0 null GSE125153_1_v_3_bcl3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Nerve Degeneration CTD Gene-Disease Associations 1.0 1.06188 GSE227592_8_v_1_adar_human RummaGEO Gene Perturbation Signatures 1.0 null RPL13AP3 Pathway Commons Protein-Protein Interactions 1.0 null HCC2157 CCLE Cell Line Gene Expression Profiles 1.0 1.84962 RPS20 Pathway Commons Protein-Protein Interactions 1.0 null MCF7_AG-490_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141889 PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Unnamed_11_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE125403_7_v_0_venetoclax_human RummaGEO Drug Perturbation Signatures 1.0 null OV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.824907 YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null