association dataset threshold value standardized value AKT1_knockout_212_GSE39699 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.11873 ETS1-20019798-JURKAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null organic substance biosynthetic process GO Biological Process Annotations 2015 1.0 null GTEX-S7PM-0006-SM-3NM8C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33117 striatum_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0089 GTEX-NPJ8-0226-SM-48TBN GTEx Tissue Sample Gene Expression Profiles 1.0 0.930101 Epithelial Ovarian Cancer DisGeNET Gene-Disease Associations 1.0 null Neuroblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.072 GTEX-XBEW-0002-SM-4AT5O GTEx Tissue Sample Gene Expression Profiles 1.0 1.28441 MAFA MotifMap Predicted Transcription Factor Targets 1.0 null H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SW 780 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.876275 BRD-K47443098 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65486 PMC11655728-12672_2024_1562_MOESM2_ESM.xlsx-Sheet1-Hs_ESC_SOX2_targets_Boyer_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null NFATC1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.554798 NCIH1385 CCLE Cell Line Gene Expression Profiles -1.0 -2.30518 head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN011_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.779 Lung adenocarcinoma_LUAD_TCGA-80-5611-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.38687 BRD-K65005459 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.49024 skeletal muscle cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Perturb_14391_KD_PAX8_SRP276625 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 14.5063 GTEX-NL4W-0008-SM-4E3I2 GTEx Tissue Sample Gene Expression Profiles 1.0 2.45013 COLO 201 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01105 gracile nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02037 H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null FF-28-ES17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.534467 CRCGN011_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.46215 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.907851 Lung squamous cell carcinoma_LUSC_TCGA-77-A5GA-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K11844860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50547 CD300LG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00606981 BRD-K46936325 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04125 CRCGN015_MCF10A.WT.HP_24H:M14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.00242 POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH650 DepMap CRISPR Gene Dependency 1.0 2.62732 CEBPB_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNF1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 77.6832 BRD-K13486159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13577 H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-483-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 BRD-K27997230 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.1504 CRCGN016_MCF10A.TP53.M_24H:M01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0893 adrenal gland GTEx Tissue Gene Expression Profiles 1.0 1.16174 BRD-K85985071_E3380_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K79me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 18689800-TableS7 GeneSigDB Published Gene Signatures 1.0 null H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Liver Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.01212 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRK-1726-SM-3NB16 GTEx Tissue Sample Gene Expression Profiles 1.0 0.935951 GTEX-R55C-0008-SM-48FCF GTEx Tissue Sample Gene Expression Profiles 1.0 1.22673 BRD-K89328601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05392 H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Carcinoma, Ovarian Epithelial DisGeNET Gene-Disease Associations 1.0 null PK1 DepMap CRISPR Gene Dependency 1.0 2.55711 GSE226091,GSE226092_0_v_4_sall1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.519 RAP1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62429 GABPA_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47465 GSE90754_0_v_1_foxo1_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-3175 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 RNA cap binding complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.112 NANOG-18358816-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052444 SUPT1 CCLE Cell Line Gene Expression Profiles 1.0 1.49195 GTEX-X4EP-0826-SM-3P5YK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.845133 L1236 DepMap CRISPR Gene Dependency 1.0 2.10988 POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT-20 GDSC Cell Line Gene Expression Profiles 1.0 2.28271 Squamous cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.184 Leukemia_chronicMyelogenousK-562 BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.93829 U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.934545 NFYA JASPAR Predicted Transcription Factor Targets 1.0 null NCI-H1155 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70H-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142019,GSE142021_10_v_3_ythdf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null SNU626 CCLE Cell Line Gene Expression Profiles -1.0 -1.7255 Central nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.15 NFIB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.377 cytoplasmic translational initiation GO Biological Process Annotations 2023 1.0 null KCNB1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00546101 YD10B CCLE Cell Line Gene CNV Profiles -1.0 -1.54434 BRD-K22093970 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46406 GSE225900_1_v_0_hsdl2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RH41 CCLE Cell Line Gene Expression Profiles -1.0 -2.1645 striatum_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1016 MAZ ENCODE Transcription Factor Targets 1.0 null ZBTB33 ENCODE Transcription Factor Targets 1.0 null CRCGN016_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.40611 Skin BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.45623 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U9-06A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JHH1 CCLE Cell Line Gene CNV Profiles 1.0 2.0642 EIF2S1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.5023 L-540 COSMIC Cell Line Gene Mutation Profiles 1.0 null KCIMOH1 DepMap CRISPR Gene Dependency 1.0 2.81575 GTEX-NL3H-0011-R7a-SM-2I3G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37049 hsa-miR-4774-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.056784 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7U9-06A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.72393 MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lymphoma Phosphosite Textmining Biological Term Annotations 1.0 null Perturb_14735_KD_ADAR1_SRP250165 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.98246 Dorsal part of the lateral geniculate complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65819 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null required GeneRIF Biological Term Annotations 1.0 null GTEX-Q2AH-0008-SM-48U2J GTEx Tissue Sample Gene Expression Profiles 1.0 1.35101 33B cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.857 Brain Lower Grade Glioma_LGG_TCGA-RY-A840-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null B-cell lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.234 GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16247 cerebral cortex HPA Tissue Protein Expression Profiles 1.0 1.17767 tonsil_8b1 HPA Tissue Sample Gene Expression Profiles 1.0 1.8117 DNMT3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73463 MCF7_Nilotinib_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0118232 dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.65143 medial vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25437 Congenital Contractural Arachnodactyly DisGeNET Gene-Disease Associations 1.0 null HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.916461 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null STAT1-17558387-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null hsa-miR-4297 TargetScan Predicted Conserved microRNA Targets 1.0 0.006367 ELF1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BE-79-QU25_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.398516 PMC10274745-media-4.xlsx-S3B-Table_S3_Reanalysis_of_publicly_available_data_to_identify_AR_and_ER_direct_target_genes_related_to_Figure_1_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OHPM-0008-SM-4E3IP GTEx Tissue Sample Gene Expression Profiles 1.0 1.10219 POU4F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 72.1811 sirolimus_mus musculus_gpl1261_gse5332 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE125014_1_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null VZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.28131 METTL22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82916 POLR2AphosphoS5_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Precancerous Conditions CTD Gene-Disease Associations 1.0 1.26794 BRD-K22683888 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37972 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tanycyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.049 facial motor nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.18669 Secondary Malignant Neoplasm Of Lymph Node DisGeNET Gene-Disease Associations 1.0 null 7466_RPL36_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.855949 dorsal lateral geniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.67002 BRD-K47748211 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43592 Perireunensis nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04128 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.843933 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17638893-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null hsa-miR-377 TargetScan Predicted Conserved microRNA Targets 1.0 0.31417 MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K11687039 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51201 organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.04085 Nerve - Tibial GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.689457 RNA cap binding GO Molecular Function Annotations 2025 1.0 null H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LC-1F GDSC Cell Line Gene Expression Profiles 1.0 2.0166 Anterior olfactory nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16944 granular layer of caudal dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.29932 superficial stratum of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.11457 extracts GeneRIF Biological Term Annotations 1.0 null UBTF ENCODE Transcription Factor Targets 1.0 null PMC8497824-Table_4.xlsx-Stage_4_EOMES_vs_Ctrl-Unnamed_1_EOMES Rummagene Transcription Factor Associations 2026 1.0 null Primary Malignant Neoplasm Of Lung DisGeNET Gene-Disease Associations 1.0 null GTEX-Q2AG-3026-SM-48U1L GTEx Tissue Sample Gene Expression Profiles 1.0 0.837901 Perturb_15084_KD_SLC4A11_SRP238854 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 5493_NCBP1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.636141 SUPM2 CCLE Cell Line Gene Expression Profiles 1.0 1.44964 POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytoplasm COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE206516,GSE206518_1_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null NCIH2087 DepMap CRISPR Gene Dependency 1.0 3.70998 SRF ENCODE Transcription Factor Targets 1.0 null hypoglossal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.42453 Gracile nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11036 POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredProteinGroups-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-3194-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.062888 CRCGN017_MCF10A.TP53.M_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.20018 outer CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.894418 H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PLZ4-0926-SM-2S1OI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.83232 SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.951104 Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61O-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1806 CCLE Cell Line Gene Expression Profiles -1.0 -1.50605 BRD-K90644597 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15337 lymphnode_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.71396 POU2F2 ENCODE Transcription Factor Targets 1.0 null A4/FUK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08965 POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null T84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.30773 amygdaloid complex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.27152 GSE218949_0_v_1_cep20_human RummaGEO Gene Perturbation Signatures -1.0 null Female reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.152 H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RHOA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.214 Pancreatic adenocarcinoma_PAAD_TCGA-YY-A8LH-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE144346_0_v_1_mettl5_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE143994_2_v_1_ythdf1_human RummaGEO Gene Perturbation Signatures 1.0 null endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Dlx2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.0688 RAD21_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.900493 GSE138468_3_v_6_dyrk1a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Diffuse large B-cell lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.242 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FF-28-ES17_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.564346 ranolazine_mus musculus_gpl1261_gse25767 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Diffuse Large B-Cell Lymphoma DisGeNET Gene-Disease Associations 1.0 null Fatty Liver DisGeNET Gene-Disease Associations 1.0 null BRD-K87209752 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02669 retropontine reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13161 skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -1.35031 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3451-01A-02R-1188-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE202434,GSE202438_8_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null FOXM1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K14122415 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.52238 HC-01-FD24_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.890365 ChIP_SOX2_18358816 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.965215 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null translation initiation factor activity GO Molecular Function Annotations 2015 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K79997957 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25943 dnabinding GeneRIF Biological Term Annotations 1.0 null Perturb_3593_KO_HRI_SRP218218 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.9566 Kidney Chromophobe_KICH_TCGA-KM-8476-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12688 ANXA9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00874104 ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POU4F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 63.3776 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WH7G-0002-SM-4LVN9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.58486 K562_Tubastatin A HCl_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0188438 CRCGN016_MCF10A.WT.HP_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.79364 GTEX-P4QT-1826-SM-2S1NJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.8047 JHOS2 CCLE Cell Line Gene CNV Profiles 1.0 1.87322 REST_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE239844_1_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null MTMR14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27004 cisplatin_mus musculus_gpl339_gse6206 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null IGROV1 BioGPS Cell Line Gene Expression Profiles -1.0 -1.25142 GTEX-PSDG-0008-SM-48TE5 GTEx Tissue Sample Gene Expression Profiles 1.0 2.32807 primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.02409 BRD-K47784292 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25694 BRD-K95213130 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62228 Field CA1, stratum lacunosum-moleculare Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07731 GSE102505_1_v_2_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XOT4-0008-SM-4B664 GTEx Tissue Sample Gene Expression Profiles 1.0 0.825428 CRCGN015_MCF10A.TP53.M_24H:L19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.10195 GSE231891_1_v_0_cdk8_human RummaGEO Gene Perturbation Signatures 1.0 null imatinib_homo sapiens_gpl96_gds3045 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K89637567 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63489 RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00821 GTEX-OHPK-1526-SM-3MJGM GTEx Tissue Sample Gene Expression Profiles 1.0 0.933575 MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4684-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.02226 involvement GeneRIF Biological Term Annotations 1.0 null NR0B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98704 GSE128099,GSE128159_3_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null Six3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.5289 Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H3-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KMS-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.829018 H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null oncoprotein GeneRIF Biological Term Annotations 1.0 null CRCGN016_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.05194 BRD-K34931072 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13308 NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.49151 hsa-miR-4328 TargetScan Predicted Conserved microRNA Targets 1.0 0.003282 baculovirus GeneRIF Biological Term Annotations 1.0 null male reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LY-01A-31R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4731-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.006367 BRD-K14520048 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04591 dorsolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.934835 FB-33-LI31_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.235156 pontobulbar body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.855219 HDQ-P1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -4.62707 hsa-miR-4502 TargetScan Predicted Conserved microRNA Targets 1.0 0.009975 GSE129725_4_v_0_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XBED-2026-SM-4AT5D GTEx Tissue Sample Gene Expression Profiles -1.0 -0.829239 GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58016 SOX2-18692474-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null hsa-miR-4682 TargetScan Predicted Conserved microRNA Targets 1.0 0.002088 hsa-miR-605 TargetScan Predicted Conserved microRNA Targets 1.0 0.002088 MPP89 CCLE Cell Line Gene CNV Profiles -1.0 -1.46397 Hepatocellular carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.033 GTEX-UTHO-3126-SM-3P5ZB GTEx Tissue Sample Gene Expression Profiles 1.0 1.42487 PML_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-320c TargetScan Predicted Conserved microRNA Targets 1.0 0.047969 PLSCR1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00376881 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GSE228106_3_v_1_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null H4K5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_5414_KD_SCRIB_SRP300624 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.19469 GSE166783_3_v_2_tp53_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Frontal pole, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.06733 GSE239844_7_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-S7SF-2226-SM-3K2BG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17951 H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K97348029 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07751 CRCGN015_MCF10A.WT.HP_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.78212 RB1_KD_GSE50532_657_human_OSTEOBLASTS GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09042 BRD-K58892587 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.92678 Lung carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.225 POU2F2_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DMPK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03886 KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.69546 ATF3-27146783-CHIP-SEQ-COLON-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K30382953 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2739 SUM52PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.57677 BRD-K41412255 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15844 hsa-miR-4762-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 MEL18_DN.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE136622_2_v_3_srpk3_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCI-H2172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.17876 BRD-K72794452 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39271 H3K79me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE165334_3_v_1_dabrafenib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.14389 EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNF4G JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4668 COV413A DepMap CRISPR Gene Dependency 1.0 2.0065 NCI-H1781 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.14917 ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular aromatic compound metabolic process GO Biological Process Annotations 2015 1.0 null CRCGN014_HEPG2_24H:P01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.77068 Small cell lung cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.52 BRD-K48782834 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00787 MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 12036940-Table2 GeneSigDB Published Gene Signatures 1.0 null Perturb_4141_KO_Apoe_SRP131850 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.02678 NUDT18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65701 COLO684 CCLE Cell Line Gene Expression Profiles -1.0 -1.92037 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.738 H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-34-5234-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GON4L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.81658 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA ENCODE Transcription Factor Targets 1.0 null BRD-K07706477 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64487 single-organism organelle organization GO Biological Process Annotations 2015 1.0 null GTEX-QCQG-0526-SM-48U2A GTEx Tissue Sample Gene Expression Profiles 1.0 0.943189 Uterus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.15 mantle zone of SeDg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21818 VHL Pathway Commons Protein-Protein Interactions 1.0 null GTEX-VUSH-0004-SM-3P61T GTEx Tissue Sample Gene Expression Profiles 1.0 2.50617 white adipose tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.162421 TCF7L2_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H4K5ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-PWN1-1526-SM-48TDA GTEx Tissue Sample Gene Expression Profiles 1.0 1.10868 BRD-K56357490 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07115 mct1 GeneRIF Biological Term Annotations 1.0 null PANC 02.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1283 HCC4017 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03246 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-RVPU-0011-R7A-SM-2XCAB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40592 UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.841498 Primary somatosensory area, unassigned, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37958 Lung adenocarcinoma_LUAD_TCGA-64-1676-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X4XY-0626-SM-4E3IN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51592 DUXA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 54.2818 H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-N7MT-1026-SM-3TW8T GTEx Tissue Sample Gene Expression Profiles 1.0 1.49353 CRCGN010_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.24801 CRCGN012_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.99432 NOMO1 Achilles Cell Line Gene Essentiality Profiles 1.0 1.06791 GSE246911,GSE246913_4_v_1_arid1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7371 SK-N-DZ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K03901181 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15332 BRD-K22139757 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.96523 inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.59859 transcriptional GeneRIF Biological Term Annotations 1.0 null CRCGN010_HEPG2_24H:D16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05412 PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-7_names_TP53 Rummagene Transcription Factor Associations 2026 1.0 null superficial stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.97123 hsa-miR-4758-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 7441_RPL17_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.915676 BRD-K57388326 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28139 GTEX-XXEK-0326-SM-4BRVV GTEx Tissue Sample Gene Expression Profiles 1.0 0.841943 HS 255.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.45279 hsa-miR-105 TargetScan Predicted Conserved microRNA Targets 1.0 0.154935 THRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.478 hsa-miR-588 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 BRD-K63987422 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.05955 CB-44-RT90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.34502 inner CP in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23949 YY1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Laryngeal cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.938 POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE123372,GSE123373_1_v_2_mecp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Granular lamina of the cochlear nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09413 BRD-K90294313 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04116 OSC19 DepMap CRISPR Gene Dependency 1.0 2.85674 VIIAt Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.986143 hsa-miR-371b-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.029271 testis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.94891 SAP30 ENCODE Transcription Factor Targets 1.0 null GTEX-RVPU-0011-R1A-SM-2XCAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66299 BRD-K07534805 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.97845 Cellular anatomical entity COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 ZBTB12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.3275 ChIP_JARID1A_20064375 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null CRCGN010_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.3236 CEBPB_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.44907 H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 20081105-ST-2 GeneSigDB Published Gene Signatures 1.0 null Perturb_7415_KD_HNRNPC_SRP040278 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.59149 cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04777 organic substance metabolic process GO Biological Process Annotations 2015 1.0 null CRCGN016_MCF10A.TP53.M_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.30788 RERFLCAD2 CCLE Cell Line Gene CNV Profiles -1.0 -1.58668 Inclusion Body Myositides_Muscle tissue_GSE3112 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.59269 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K47338154 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19092 BRD-K31187110 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09328 7312_RIOK2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.590416 cell part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 Breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.52 GTEX-RM2N-0008-SM-48FF3 GTEx Tissue Sample Gene Expression Profiles 1.0 2.06256 7515_RPS26_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.662526 NANOG ChEA Transcription Factor Targets 1.0 null POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-3977 TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 external part of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53402 8903_TIAL1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.504744 GTEX-RNOR-0526-SM-2TF4O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07376 PMC8025515-12859_2021_4105_MOESM12_ESM.xlsx-PW1-gene_stable_id_PEG3 Rummagene Transcription Factor Associations 2026 1.0 null pkamediated GeneRIF Biological Term Annotations 1.0 null decitabine_homo sapiens_gpl570_gse30985 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE243491_1_v_2_oxaliplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer II of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.999815 H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE88819_6_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC11531655-MCO2-5-e754-s001.docx-0-IRF7_Regulon_4_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K30176130 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06922 KYSE-150 GDSC Cell Line Gene Expression Profiles 1.0 2.41044 cellular metabolic process GO Biological Process Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RN-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null non-Hodgkin lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.209 CRCGN017_MCF10A.WT.HP_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0959 hsa-miR-4659a-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null ventrolateral prefrontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.21993 Lung adenocarcinoma_LUAD_TCGA-05-5423-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22342 GTEX-U3ZN-0226-SM-3DB8D GTEx Tissue Sample Gene Expression Profiles 1.0 0.951554 CRCGN014_HEPG2_24H:K06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.10187 MMP28 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00557605 SkeletalMuscle BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.966927 POLR2A_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7459_RPL31_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.578427 CRCGN012_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.17627 PMC10153265-media-3.xlsx-BENPORATH_NANOG_TARGETS_v2023_1-STANDARD_NAME_NANOG Rummagene Transcription Factor Associations 2026 1.0 null 10766_NON-TARGETING_NON-TARGETING Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.695209 NANOG-21062744-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null FRTL-5 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.732 Prostate adenocarcinoma_PRAD_TCGA-J4-A67K-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RPMI-8226 GDSC Cell Line Gene Expression Profiles 1.0 1.85462 NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.46087 GTEX-S7PM-0011-R5A-SM-3NM8G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75784 GTEX-WVLH-0011-R7A-SM-3MJFB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02664 BRD-A21524347 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19815 MPP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40677 Bed nuclei of the stria terminalis, anterior division, ventral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66468 hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.44419 BCL11A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00606193 BRD-K37740343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25495 superficial stratum of CoPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.0999 intermediate stratum of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58768 MCF7_Prednisone_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150666 RERFLCAI DepMap CRISPR Gene Dependency 1.0 3.1273 253J cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.681 H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE151829,GSE151831_5_v_8_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null LN-229 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.838544 u698 HPA Cell Line Gene Expression Profiles 1.0 0.867309 GSE200320_3_v_2_mfge8_mouse RummaGEO Gene Perturbation Signatures -1.0 null Epithelium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.21 GABPA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_6169_KD_PROX1_SRP073100 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.96884 BRD-K73364700 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.92304 GSE206516,GSE206518_6_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE184892_4_v_2_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null A549_Tozasertib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0169303 cerebellar cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.39476 H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null PMC7797150__F4 PFOCR Pathway Figure Associations 2023 1.0 null GB-57-XV52_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.5089 GSE129153_0_v_1_forskolin_human RummaGEO Drug Perturbation Signatures 1.0 null periventricular stratum of p3ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09438 GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44072 Eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.141 CYB5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3606 BRD-K32063762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47249 valproic acid_homo sapiens_gpl96_gds1050 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-Q2AG-0011-R9A-SM-2HMJ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40811 8517_STK24_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.705335 POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null diethylstilbestrol_rattus norvegicus_gpl1355_brown norway_gds2913 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K34720817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25983 GSE102505_1_v_0_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE235701,GSE261434_0_v_1_enasidenib_human RummaGEO Drug Perturbation Signatures -1.0 null regulation of gene expression GO Biological Process Annotations 2015 1.0 null hsa-miR-1976 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 BRD-K80803211 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26835 formation of translation preinitiation complex GO Biological Process Annotations 2025 1.0 null CRCGN014_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.51265 PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053587 7449_RPL23A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.760277 SOX2-27498859-CHIP-SEQ-STOMACH-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE196104,GSE196106_2_v_0_vsx2_mouse RummaGEO Gene Perturbation Signatures 1.0 null organic cyclic compound metabolic process GO Biological Process Annotations 2015 1.0 null PMC8327141__F4 PFOCR Pathway Figure Associations 2024 1.0 null CRCGN014_HEPG2_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.03707 7451_RPL24_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.597336 LS-123 GDSC Cell Line Gene Expression Profiles 1.0 1.60802 CRCGN017_MCF10A.WT.HP_24H:D21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05045 NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.26174 BRD-K66324291 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06269 Hematologic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.437 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE133683_1_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures 1.0 null 496100384_HIP_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.32726 fibroblasts Phosphosite Textmining Biological Term Annotations 1.0 null PMC11876530-3214633.f4.pdf-130-ZMAT1_ZMAT1 Rummagene Transcription Factor Associations 2026 1.0 null BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.910134 BRD-K85697068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49766 MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Dmbx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.6681 PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Symbol_FOXM1 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-1285 TargetScan Predicted Conserved microRNA Targets 1.0 0.23348 BRD-K52319351 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.60496 Cervical epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.523 GTEX-QVJO-0011-R2A-SM-2S1QK GTEx Tissue Sample Gene Expression Profiles 1.0 0.918659 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YV-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null vertebrate muscular system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null COLO-704 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.42484 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A5SK-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NRL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.7382 Prelimbic area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.11206 GTEX-Q2AH-1126-SM-48TZM GTEx Tissue Sample Gene Expression Profiles 1.0 1.01039 ZNF155 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78262 BB-87-SF89_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.577551 IPO5 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-1290 TargetScan Predicted Conserved microRNA Targets 1.0 0.02452 GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3613 Supplemental somatosensory area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09658 CAL-120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.924342 H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJMC-0008-SM-4IHKK GTEx Tissue Sample Gene Expression Profiles 1.0 1.82963 SKGT4 DepMap CRISPR Gene Dependency 1.0 2.42003 hsa-miR-3942-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.053794 STAT3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1 ENCODE Transcription Factor Targets 1.0 null EB1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.8262 POLR2A_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null translational initiation GO Biological Process Annotations 2015 1.0 null CRCGN015_MCF10A.WT.HP_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.44283 cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.924305 GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles -1.0 -2.66077 H4K20me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RNF227 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87447 GTEX-PWO3-1026-SM-2I5F2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06619 Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EF-01A-12R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2073 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07753 H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null increased total body fat amount IMPC Knockout Mouse Phenotypes 1.0 null Field CA3, stratum oriens Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50554 demonstrated GeneRIF Biological Term Annotations 1.0 null H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.39837 HUH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.880833 NC-52-HX69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.375774 GTEX-OXRO-0011-R9A-SM-3NB1X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.907804 hsa-miR-3605-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.034317 2543_EIF2S3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.538627 CRCGN016_MCF10A.WT.HP_24H:A22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.63479 CRCGN017_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.1466 FB-66-UU47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.529721 GTEX-RU72-0011-R9A-SM-2TF67 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26678 brain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Parasympathetic ganglion TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.511 CRCGN017_MCF10A.WT.HP_24H:P10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0935 KURAMOCHI Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -5.01051 GTEX-RVPV-0008-SM-47JYW GTEx Tissue Sample Gene Expression Profiles 1.0 1.96826 dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.967969 NEDD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42472 K562_Ki16425_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0194415 ZNF384_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null eGFP-GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K28952606 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49989 BRD-K77548697 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88011 FA-63-WI26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.655064 BRD-K22216962 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51912 PMC11618734-ac4c05127_si_004.xlsx-OPTI-PISA_automated_MTX_900ng-Unnamed_2_ZNF568 Rummagene Transcription Factor Associations 2026 1.0 null abducens nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.980861 High-Risk Neuroblastoma DisGeNET Gene-Disease Associations 1.0 null BRD-K60781525 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63447 ELF1 ENCODE Transcription Factor Targets 1.0 null CJUN-26792858-CHIP-SEQ-BT549-HUMAN ChEA Transcription Factor Targets 2022 1.0 null 7505_RPS16_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.589805 PMC12260418-pnas.2425984122.sd01.xlsx-TEAD4_6fraction_test_result-Unnamed_3_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null biological_process GO Biological Process Annotations 2015 1.0 null hsa-miR-3691-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.226173 hsa-miR-4694-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.031759 BRD-K37830990 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28033 RFX5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE207514,GSE207515_2_v_3_acetylcysteine_human RummaGEO Drug Perturbation Signatures -1.0 null periventricular stratum of r8Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42681 SmoothMuscle BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.98804 10663_ZNF830_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.752914 A549_CUDC-101_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.012587 BRD-K88620071 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05566 JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_951_KO_Suz12_SRP322809 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -11.9174 CAOV3 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.71262 cell periphery COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN010_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.08501 Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 hsa-miR-4429 TargetScan Predicted Conserved microRNA Targets 1.0 0.047969 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.678 orbital frontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00231 BRD-K42862653 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7615 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBXN1 Pathway Commons Protein-Protein Interactions 1.0 null RQC complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.549 BRD-K03916755 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34457 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null shell of p3ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09438 BRD-A94740628 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56525 SMC3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Q7-0003-SM-3NM8M GTEx Tissue Sample Gene Expression Profiles 1.0 1.41738 SP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.29771 PMC8528285-pbio.3001085.s010.xlsx-Fig_S7B-GENE_LIST_UPLOADED_TO_ENRICHR_MAX_WT_TESTES_874_GENES_MAX Rummagene Transcription Factor Associations 2026 1.0 null HEP3B217 CCLE Cell Line Gene Expression Profiles -1.0 -2.90102 striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.916717 H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRPL47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26252 17210682-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null OE-31-YC41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.16152 USF2 ENCODE Transcription Factor Targets 1.0 null FOXB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 55.9984 GSE218907_3_v_2_opa1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K10010414 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21161 Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H4K91ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.498085 hsa-miR-137 TargetScan Predicted Conserved microRNA Targets 1.0 0.029271 POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular component organization or biogenesis GO Biological Process Annotations 2015 1.0 null BRD-K23593468 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31977 GSE111247_2_v_3_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE202434,GSE202438_6_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K13044705 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.169 PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A Rummagene Transcription Factor Associations 2026 1.0 null BRD-K30682979 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02288 Uncharacterised domain CHP00451 InterPro Predicted Protein Domain Annotations 1.0 null H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE242290_1_v_0_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null alitretinoin_homo sapiens_gpl6480_gse43090 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H1734 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.32408 KA-71-CQ35_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.21021 Perturb_2758_KD_PRMT1_SRP214436 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.29982 against GeneRIF Biological Term Annotations 1.0 null H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HCT-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.0838 TWF1 Pathway Commons Protein-Protein Interactions 1.0 null GSE200352_9_v_6_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K34106082 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69415 paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.18569 BRD-K88625883 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04906 testis_7b HPA Tissue Sample Gene Expression Profiles -1.0 -0.896359 9366_TSR2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.599654 T-Cell Lymphoma DisGeNET Gene-Disease Associations 1.0 null GSE225218_2_v_3_abcb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SK-N-FI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.970255 BRD-K26282994 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13004 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.982391 microphthalmia MGI Mouse Phenotype Associations 2023 1.0 null GTEX-U3ZM-0626-SM-4DXTV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849251 BRD-K38450726 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20039 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.18056 GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -2.02548 BRD-A60245366_AS-601245_SKBR3_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZY-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null BRD-K92358687 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17151 SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.43235 HD-51-KD29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.396711 POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-889 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 BEN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.68276 GSE193541_1_v_2_nifurtimox_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XMD1-2826-SM-4AT5F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31562 GTEX-SSA3-0002-SM-3P61R GTEx Tissue Sample Gene Expression Profiles 1.0 1.18669 r9 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07242 NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00821 SQ1 CCLE Cell Line Gene CNV Profiles 1.0 1.55014 menadione_mus musculus_gpl1261_gds4171 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XXEK-0826-SM-4BRWG GTEx Tissue Sample Gene Expression Profiles 1.0 0.879432 BRD-K14451397 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26572 CREB1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K61027868 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70366 GTEX-O5YT-0008-SM-4E3IQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.87125 occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.853379 LOU-NH91 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01495 GSE134375_0_v_5_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null proliferation Phosphosite Textmining Biological Term Annotations 1.0 null BRD-K89364982 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22463 ribosome disassembly GO Biological Process Annotations 2025 1.0 null 7455_RPL27_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.3744 H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-RWSA-0005-SM-2XCAO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81954 hsa-miR-653 TargetScan Predicted Conserved microRNA Targets 1.0 0.050854 4108_IMP4_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.64581 BRD-K09991945_GSK-3 Inhibitor II_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A39996500_radicicol_HEPG2_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Hyperinsulinemic Hypoglycemia DisGeNET Gene-Disease Associations 1.0 null POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:E20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.98242 bladder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.0751 PHF8 ENCODE Transcription Factor Targets 1.0 null u251mg HPA Cell Line Gene Expression Profiles 1.0 1.02873 TT2609C02 DepMap CRISPR Gene Dependency 1.0 3.31105 Mitotic fetal germ cell_Fetal gonad_Human CellMarker Gene-Cell Type Associations 1.0 null CRCGN009_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5171 r9 portion of vagal motor nucleus (postmigratory) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.00171 SOX2-16153702-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PMC6488577-41598_2019_43010_MOESM2_ESM.xlsx-Proteingroups_MBD3_pos-Gene_names_MBD3 Rummagene Transcription Factor Associations 2026 1.0 null SETDB1 ENCODE Transcription Factor Targets 1.0 null RASAL2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0080212 TCF7L2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QESD-0626-SM-2I5G4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.838468 BRD-K34677894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.87047 A172 BioGPS Cell Line Gene Expression Profiles -1.0 -0.964762 GA-88-CF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.348403 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4699-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Retinal pigment epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.38 POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null paraseptal subpallium Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03718 cerebellar cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.995633 H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A8HY-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K70193997 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12525 IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.6213 Nuclear cap binding complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.259 BICR 10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.28298 Lung adenocarcinoma_LUAD_TCGA-95-8494-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K16330310 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34572 H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K79me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BA-84-WN26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.383696 icSARA deltaORF6_0Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.60008 MF-04-HB41_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.231022 PIGQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16649 H3K27ac_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K77108738 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18067 7438_RPL14_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.69739 ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HuH-7 GDSC Cell Line Gene Expression Profiles -1.0 -1.49905 GTEX-T5JC-0005-SM-4DM7B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28378 Primary somatosensory area, mouth, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01944 AGS DepMap CRISPR Gene Dependency 1.0 4.08889 cell part LOCATE Predicted Protein Localization Annotations 1.0 null GSE158834_7_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.842286 REST_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ovary_6a HPA Tissue Sample Gene Expression Profiles -1.0 -0.927651 H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null 537 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.831953 BRD-K63960902 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05142 b-cell Phosphosite Textmining Biological Term Annotations 1.0 null BRD-A66164310 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42298 CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral spiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.82748 GTEX-W5WG-1126-SM-4LMK4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.933662 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050459 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GR-06A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4271 TargetScan Predicted Conserved microRNA Targets 1.0 0.004732 BRD-K08355771 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20085 RAD21_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 20103679-ST3-B GeneSigDB Published Gene Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A763-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF85 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.2055 Hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.096 KDM4E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1846 BRD-K21412601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52315 BRD-K96737756 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28758 SEKI DepMap CRISPR Gene Dependency 1.0 2.6345 BRD-K58300049 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52762 PITX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.7456 GRIK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00515118 Neoplasm Metastasis DisGeNET Gene-Phenotype Associations 1.0 null spanning component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.219265 Brain Lower Grade Glioma_LGG_TCGA-S9-A7R8-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE202434,GSE202438_13_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K30467307 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.04392 H3K27ac_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K36726853 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4436 HC-74-HM63_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.435569 GTEX-XOTO-0426-SM-4B66A GTEx Tissue Sample Gene Expression Profiles -1.0 -0.872004 NR2C2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cecum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.276 BACH1 ENCODE Transcription Factor Targets 1.0 null Insulinoma DisGeNET Gene-Disease Associations 1.0 null BRD-K87126326 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45299 YSK4 Kinase Library Serine Threonine Kinome Atlas 1.0 null BRD-K08554278_Hoechst 33342 (cell permeable) (BisBenzimide)_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null LK2 DepMap CRISPR Gene Dependency 1.0 4.2825 GTEX-R55E-0008-SM-48FCG GTEx Tissue Sample Gene Expression Profiles 1.0 1.25535 RCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.82863 GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2666 Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5835-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12205 BRD-K41498330 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09965 GSE155567_1_v_0_cd33_human RummaGEO Gene Perturbation Signatures -1.0 null medial part of MPO Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6349 Primary somatosensory area, trunk, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32441 CB-16-SY72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.406614 517_ARL6IP6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.771787 GBAF complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.857 Lung squamous cell carcinoma_LUSC_TCGA-66-2763-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XGQ4-1526-SM-4AT6H GTEx Tissue Sample Gene Expression Profiles 1.0 1.00684 SP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.29702 Nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.319 ribavirin_homo sapiens_gpl570_gds4391 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE66014_0_v_1_perhexiline_human RummaGEO Drug Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.32285 BRD-K05118861 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10546 hsa-miR-3143 TargetScan Predicted Conserved microRNA Targets 1.0 0.008128 Dlx4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 13.89 BRD-K75207324 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46947 GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -4.16969 NCVADR RES BioGPS Cell Line Gene Expression Profiles -1.0 -1.16792 4T1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.629 H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Congenital Hyperinsulinism DisGeNET Gene-Disease Associations 1.0 null CRCGN009_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.13318 ChIP_NANOG_18358816 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K83949633 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07917 K562_Fluorouracil_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0204923 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3471-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S7SF-0426-SM-3K2B7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.44725 SNU869 CCLE Cell Line Gene Expression Profiles -1.0 -2.06537 H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BPH-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -4.09056 hsa-miR-3120-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.303626 DF-00-BU08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.223089 EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26689 BRD-K89199943 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57576 SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04777 ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RKO-E6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.55706 Nucleus of reunions Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50016 H3K4me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE101112_6_v_4_j147_mouse RummaGEO Drug Perturbation Signatures -1.0 null binding GO Molecular Function Annotations 2015 1.0 null DD-75-HY40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.39182 GSE162739_7_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE111247_2_v_7_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K26479796 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6454 GSE242290_3_v_10_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null outer SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15306 hsa-miR-4675 TargetScan Predicted Conserved microRNA Targets 1.0 0.145356 POLR2A_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nucleus of the solitary tract, gelatinous part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.08102 Prostate adenocarcinoma_PRAD_TCGA-EJ-A46F-01A-31R-A250-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cisplatin_homo sapiens_gpl570_gds3910 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-QEG4-0626-SM-2S1OY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16196 primary motor cortex (area M1, area 4)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.877259 ZNF263 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6K1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null interstitial nucleus of Cajal, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.918325 cerebellar cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.863222 GTEX-X261-0011-R6B-SM-4E3J8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7104 GTEX-TSE9-3126-SM-4DXSY GTEx Tissue Sample Gene Expression Profiles 1.0 1.42676 GSE228106_3_v_5_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.57246 Osteosarcoma DisGeNET Gene-Disease Associations 1.0 null C8orf33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15273 MAX_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sepsis_Splenocyte_GSE4479 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.60993 H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null exhibited GeneRIF Biological Term Annotations 1.0 null SYK_druginhibition_289_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.35325 BT20 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.68667 BRD-K87930002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11815 periventricular stratum of r9Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.00353 lateral tuberal nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22248 EGR1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.7071 medial preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.82502 SMC3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null site GeneRIF Biological Term Annotations 1.0 null SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.4153 GSE145915_3_v_2_pcm1_mouse RummaGEO Gene Perturbation Signatures 1.0 null JMSU1 CCLE Cell Line Gene CNV Profiles 1.0 1.61174 GTEX-V1D1-0003-SM-3NMDP GTEx Tissue Sample Gene Expression Profiles 1.0 1.47534 PMC6326667__F5 PFOCR Pathway Figure Associations 2023 1.0 null GSE135312_1_v_2_bmpr2_human RummaGEO Gene Perturbation Signatures -1.0 null Perturb_4540_KD_Bahd1_SRP126769 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.88683 H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K67526257 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04453 Malignant Pleural Mesothelioma DisGeNET Gene-Disease Associations 1.0 null 7474_RPL4_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.512281 CRCGN016_MCF10A.WT.HP_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.81536 GTEX-WK11-2526-SM-3NM9Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831142 SATB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.2006 AC-74-ZA35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.447662 control GeneRIF Biological Term Annotations 1.0 null GTEX-PVOW-2726-SM-48TCA GTEx Tissue Sample Gene Expression Profiles 1.0 1.27055 hsa-miR-3065-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 HUH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.841498 AB-43-XJ34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.228259 heterocyclic compound binding GO Molecular Function Annotations 2015 1.0 null Perturb_9837_KD_GCN2_SRP248465 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.57707 subbrachial nucleus, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.6673 BRD-K39913853 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73609 PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5B-Up_H3K4me3_DPY30_KD-Unnamed_12_AR Rummagene Transcription Factor Associations 2026 1.0 null SOX2-18692474-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIM28_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7536_RPS6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.548402 GTEX-PX3G-0008-SM-48U2L GTEx Tissue Sample Gene Expression Profiles 1.0 2.80905 BRD-K25761766 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25846 anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.25307 GTEX-N7MS-0426-SM-2YUN6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32364 SRSF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5768 hsa-miR-4272 TargetScan Predicted Conserved microRNA Targets 1.0 0.026857 HEP G2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.25412 GSE258991_5_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null PMC8017594-LSA-2019-00332_Table_S1_Table_12.xls-DCX-KD_LIS1-KD_DEGs-LIS1-KD_AR Rummagene Transcription Factor Associations 2026 1.0 null SNU601 DepMap CRISPR Gene Dependency 1.0 3.31014 Carcinoma Of Lung DisGeNET Gene-Disease Associations 1.0 null Lymphatic system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.411 CRCGN017_MCF10A.TP53.M_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.74409 Carcinoma, Hepatocellular CTD Gene-Disease Associations 1.0 1.10175 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51R-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-GSEA_TET1-Unnamed_2_TET1 Rummagene Transcription Factor Associations 2026 1.0 null HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12917 FC-85-OX77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.264822 ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.034 Lung adenocarcinoma_LUAD_TCGA-05-4397-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cytoplasmic translational initiation GO Biological Process Annotations 2025 1.0 null CC-70-BD07_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.228499 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4352-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE199606_1_v_4_csf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null superficial stratum of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03323 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.36087 GTEX-RWSA-0008-SM-47JYX GTEx Tissue Sample Gene Expression Profiles 1.0 2.85015 BRD-A14842104 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41559 NANOG-18347094-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.214 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FADU Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.72871 MEKK1 Kinase Library Serine Threonine Kinome Atlas 1.0 null BRD-K87884409 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08351 GTEX-T2YK-0008-SM-4DM6M GTEx Tissue Sample Gene Expression Profiles 1.0 1.445 periventricular stratum of PO2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.92274 Thoracic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.516 imatinib_homo sapiens_gpl96_gds3049 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ERF::SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.119 outer SZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07946 Perturb_13119_KO_Dnajc11_SRP404364 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 H3K4ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Field CA3, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35427 CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K10092312 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10383 CRCGN015_HEPG2_48H:F04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.09488 primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.42395 TEAD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LCP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00626726 GSE213228_2_v_0_irak2_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K18ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null fastigial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.99344 POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hepatobiliary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.174 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K61560971 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12068 CRCGN008_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.1868 H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_62_KD_Ccnt2_SRP312148 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.87228 ELK1 ChEA Transcription Factor Targets 1.0 null dorsolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.15287 DOR 13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.838544 BRD-K87412446 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46897 Adenocarcinoma DisGeNET Gene-Disease Associations 1.0 null H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KCNQ2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00510368 cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19851 CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.39887 MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QXCU-0626-SM-2TC69 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89377 7251_RFFL_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.531054 Sarcoglycan complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.598 GTEX-W5X1-0826-SM-3GILN GTEx Tissue Sample Gene Expression Profiles 1.0 0.953046 Hnf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 39.4396 H3K27ac_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NLGN3_KD_GDS4759_336_mouse_E16 primary cortical neuron cultures GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null rh30 HPA Cell Line Gene Expression Profiles -1.0 -1.05116 H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HDGF Pathway Commons Protein-Protein Interactions 1.0 null BRD-A60487173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21527 GTEX-O5YT-0526-SM-32PK8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21914 Sarcoma_SARC_TCGA-DX-A8BH-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09678 ZFP281-18358816-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null nucleobase-containing compound biosynthetic process GO Biological Process Annotations 2015 1.0 null TWF2 Pathway Commons Protein-Protein Interactions 1.0 null UBE2D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37282 MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U4B1-1126-SM-4DXV3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.962477 PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null S0-EE-Y7IR_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.47063 ETS1 ChEA Transcription Factor Targets 1.0 null imatinib_homo sapiens_gpl96_gds3042 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.126 KCI-MOH1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04453 GSE132408_1_v_3_tet2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-X4XY-0006-SM-46MV2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29944 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39V-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FCRL5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00630736 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GSE136622_0_v_3_srpk3_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K35442564 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22063 NANOG-21062744-HESC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051549 GTEX-XUJ4-2826-SM-4BOQ2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.876814 GTEX-PX3G-0926-SM-48U12 GTEx Tissue Sample Gene Expression Profiles 1.0 0.84854 KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_8840_KO_AKIRIN2_SRP281428 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.41778 496100574_HIP_possible Alzheimer's disease_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.20015 MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09514 GSE216043_10_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null C32TG Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.957574 BRD-A57982699 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.99534 GTEX-T2IS-0011-R3A-SM-32QPB GTEx Tissue Sample Gene Expression Profiles 1.0 1.34505 BRD-K10130686 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89761 YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null preadipocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.406315 caudal presubiculum (postsubiculum) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.73845 BRD-K35462157 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32978 B-lymphoblastoid cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.22 Lymphoid cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.727 SUM44PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.600695 18667080-TableS2 GeneSigDB Published Gene Signatures 1.0 null MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mitosis GeneRIF Biological Term Annotations 1.0 null YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWOO-2326-SM-2S1PQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40796 COPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26136 Glioblastoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.147 GTEX-XOTO-0011-R5A-SM-4B657 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.948176 microphthalmia IMPC Knockout Mouse Phenotypes 1.0 null ZNF384 ENCODE Transcription Factor Targets 1.0 null induced GeneRIF Biological Term Annotations 1.0 null FGFR1_activemutant_58_GSE17916 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.15852 FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.448887 H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFG8-0006-SM-3GIKS GTEx Tissue Sample Gene Expression Profiles 1.0 0.828209 hsa-miR-3945 TargetScan Predicted Conserved microRNA Targets 1.0 0.069137 H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.2513 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5175-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ebolavirus(EBOV)_5day_Splenocytes_19683682_GSE17509 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.99846 G protein-coupled GABA receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.714 MAPK1 PhosphoSitePlus Substrates of Kinases 1.0 null H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null OVCAR433 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.50057 primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.90692 GTEX-Q2AG-0426-SM-2S1PU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05704 Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Childhood Neuroblastoma DisGeNET Gene-Disease Associations 1.0 null H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null GABPA_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.423 Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.174 496100355_HIP_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.14149 bonemarrow_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.02946 SNU878 CCLE Cell Line Gene Expression Profiles -1.0 -1.73737 GSE205976,GSE205978_3_v_0_cep83_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-VUSG-0003-SM-3NMDK GTEx Tissue Sample Gene Expression Profiles 1.0 1.71094 BRD-K10241968 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23702 Bronchoalveolar system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.21 POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null promote GeneRIF Biological Term Annotations 1.0 null CHAGOK1 CCLE Cell Line Gene Expression Profiles -1.0 -1.8898 Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.24465 GSE62843,GSE64371_2_v_3_furan_mouse RummaGEO Drug Perturbation Signatures -1.0 null CRCGN010_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.02696 hsa-miR-4727-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.09606 RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Z8-1826-SM-3K2BH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02389 MAFK ENCODE Transcription Factor Targets 1.0 null 9804_WDR12_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.682782 hsa-miR-548p TargetScan Predicted Conserved microRNA Targets 1.0 0.136254 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r8 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09597 HOXB13-26457646-LNCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null macromolecular complex assembly GO Biological Process Annotations 2015 1.0 null PPARalpha:RXRalpha MotifMap Predicted Transcription Factor Targets 1.0 null CRCGN013_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.90961 BRD-K25305749 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23271 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PWN1-1626-SM-2S1OL GTEx Tissue Sample Gene Expression Profiles -1.0 -2.12344 SPI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7444_RPL19_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.544522 BRD-A06149038 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37612 NOL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52186 TMEM255A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0050462 SPI1_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -1.74532 BRD-K69438930 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30071 GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23245 GTEX-WYVS-0526-SM-3NM9W GTEx Tissue Sample Gene Expression Profiles 1.0 1.21054 POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRKRA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38797 Hmx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.0382 organelle disassembly GO Biological Process Annotations 2023 1.0 null IZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.831457 HCC1599 CCLE Cell Line Gene CNV Profiles 1.0 2.40294 Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null myb_16205643_mcf7_gof_human_gpl96_gse2815 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -1.23825 r5 part of the cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03263 H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VMRCLCD CCLE Cell Line Gene CNV Profiles 1.0 1.4803 CDK2_knockdown_132_GSE31534 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.3632 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4116-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PSDG-0426-SM-2S1OF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62299 SOX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.3298 plasma membrane GO Cellular Component Annotations 2015 1.0 null MCF7_Ofloxacin_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0118947 hsa-miR-1206 TargetScan Predicted Conserved microRNA Targets 1.0 0.029271 damage Phosphosite Textmining Biological Term Annotations 1.0 null Perturb_1367_KD_IGF2BP1_SRP252209 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.67044 AC-30-XU83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.238403 substantia nigra, pars reticulata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1219 mantle zone of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17055 HSPA1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00537971 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.271 Ovarian Neoplasm DisGeNET Gene-Disease Associations 1.0 null POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null chrX_120617080_G_A_b38 GTEx eQTL 2025 1.0 3.80405 r10 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.60697 Fetal Death CTD Gene-Disease Associations 1.0 1.02485 GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.73613 SRF_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null QE-79-XO29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.499531 BRD-K65913831 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14044 RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14078 POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K23617623 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34935 GSE151090_0_v_4_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K86237035 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25168 GTEX-R55G-0008-SM-48FEX GTEx Tissue Sample Gene Expression Profiles 1.0 0.860832 H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null NP3 DepMap CRISPR Gene Dependency 1.0 5.55644 7206_RCL1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.570636 POLR2AphosphoS2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GYG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51791 BRD-K18724229_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7415402-oncotarget-11-2995-s004.xlsx-EWS-FLI1_Type_2_vs_Type_3-Gene_Symbol_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null BB-87-SF89_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.269589 Perturb_8460_KO_IFNLR1_ERP121014 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.16291 Lung adenocarcinoma_LUAD_TCGA-05-4434-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AA-11-RO46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.335444 GTEX-T6MN-0002-SM-3NMAH GTEx Tissue Sample Gene Expression Profiles 1.0 1.89304 lateral terminal nucleus of the accessory optic tract, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.0999 RS5 CCLE Cell Line Gene Expression Profiles -1.0 -1.52478 central portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.30414 ZBTB33_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.4031 Ovary Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.17018 JF-30-FW92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.244475 7461_RPL34_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.556451 ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null BRD-K63809385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08816 PMC7415402-oncotarget-11-2995-s004.xlsx-EWS-FLI1_Type_1_vs_Type_2-Gene_Symbol_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null HCC1534 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.13031 CA-75-HA22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.263949 GTEX-O5YT-1326-SM-3MJGR GTEx Tissue Sample Gene Expression Profiles 1.0 1.18279 GTEX-RU72-3126-SM-46MUB GTEx Tissue Sample Gene Expression Profiles 1.0 1.21043 BB-20-UU03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.356224 GTEX-X585-0002-SM-46MVA GTEx Tissue Sample Gene Expression Profiles 1.0 1.97367 BRD-K45380779 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04171 H3K23ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CA11 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00603544 USF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3691 macromolecular complex subunit organization GO Biological Process Annotations 2015 1.0 null BRD-K43729445 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01276 BRD-K29662589 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43409 hsa-miR-302f TargetScan Predicted Conserved microRNA Targets 1.0 0.082179 H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VZ in subgenual cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.57352 useful GeneRIF Biological Term Annotations 1.0 null Sepsis_Hepatic Tissue_GSE1781 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 0.890122 GTEX-VUSG-2626-SM-4KKZI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28957 H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2F1 ChEA Transcription Factor Targets 1.0 null Sarcoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN017_MCF10A.WT.HP_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.05785 regulation of biological process GO Biological Process Annotations 2015 1.0 null K562_Amisulpride_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0176222 inner CP in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03183 r5 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25338 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-VW-A7QS-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TMMY-0005-SM-33HBN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48314 Kidney cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.022 BRD-K89094496 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78278 5933_OGT_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.530877 SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.56395 m2 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3275 GTEX-SUCS-0008-SM-4DM53 GTEx Tissue Sample Gene Expression Profiles 1.0 1.69593 2132_DDX56_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.684069 CRCGN015_MCF10A.TP53.M_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.98035 NCIH1651 CCLE Cell Line Gene Expression Profiles -1.0 -1.4546 PMC12695649-41588_2025_2389_MOESM2_ESM.xlsx-GATA6_RIME-_AsPC-1-Gene_Symbol_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YA-92-YO01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.806352 GSE242083,GSE242098_3_v_0_med1_human RummaGEO Gene Perturbation Signatures 1.0 null 7439_RPL15_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.718584 Corneal edema DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.066 dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.856192 GTEX-U4B1-1626-SM-3DB8N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14251 hsa-miR-942 TargetScan Predicted Conserved microRNA Targets 1.0 0.165047 GTEX-P4QT-1626-SM-2S1NP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05236 KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T2IS-0008-SM-4DM75 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10093 Kidney Chromophobe_KICH_TCGA-KL-8339-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K98695520 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42062 Perturb_7154_OE_MOV10_SRP029367 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.25044 CRCGN017_MCF10A.WT.HP_24H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.00375 ventrolateral prefrontal cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.32943 cerebellar cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.66649 AKT1_activemutant_10_GDS2304 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.49 GSE93309_5_v_0_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null r6 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55234 pancreas HPA Tissue Gene Expression Profiles -1.0 -0.85659 GSE221327_6_v_11_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null AURKA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0055611 deep layers of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.11703 H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.0361 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KURAMOCHI GDSC Cell Line Gene Expression Profiles -1.0 -2.0652 POLE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09634 PLB985 CCLE Cell Line Gene CNV Profiles -1.0 -2.59447 H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Childhood Burkitt Lymphoma DisGeNET Gene-Disease Associations 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J2-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Muscle Damage DisGeNET Gene-Phenotype Associations 1.0 null A1207 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.92485 GSE149901_2_v_0_anlotinib_human RummaGEO Drug Perturbation Signatures 1.0 null MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null synergistically GeneRIF Biological Term Annotations 1.0 null EVSAT DepMap CRISPR Gene Dependency 1.0 3.84346 H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-V955-0004-SM-3NMDH GTEx Tissue Sample Gene Expression Profiles 1.0 1.31879 Eye TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NLGN1_KD_GDS4759_335_mouse_E16 primary cortical neuron cultures GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K00300115 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35251 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EZH2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6R0-01A-12R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 hsa-miR-4310 TargetScan Predicted Conserved microRNA Targets 1.0 0.293524 Btb cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.202 CEP78 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27749 Lung adenocarcinoma_LUAD_TCGA-75-5147-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JC-06-ED36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.992766 dorsolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.73711 basal ventral medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.65789 H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null liminal alar domain of m2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66974 GSE202933_1_v_0_ugt2b28_human RummaGEO Gene Perturbation Signatures 1.0 null UMUC6 DepMap CRISPR Gene Dependency 1.0 4.27581 CRCGN015_MCF10A_48H:E17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.2058 GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0492 hsa-miR-4701-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cytoplasm LOCATE Predicted Protein Localization Annotations 1.0 null Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.364 A549 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.29292 PMC9576445-IJG2022-9264555.nxml--Potential_targets_of_hsa-miR-15b-5p_AND_hsa-miR-184_NOT_hsa-miR-16-5p_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-30e TargetScan Predicted Conserved microRNA Targets 1.0 0.050854 NANOG-18692474-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-TSE9-1226-SM-4DXTM GTEx Tissue Sample Gene Expression Profiles 1.0 0.900133 hsa-miR-626 TargetScan Predicted Conserved microRNA Targets 1.0 0.241055 r7 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37958 BRD-K44004565 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29206 POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ribosomal small subunit binding GO Molecular Function Annotations 2025 1.0 null periventricular stratum of r9Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07242 BRD-K66821167 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15557 Hyperglycemia DisGeNET Gene-Disease Associations 1.0 null BRD-K22322324_5120-0434_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE264621_1_v_6_secretin_human RummaGEO Drug Perturbation Signatures 1.0 null Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.74971 NANOG-16153702-HESC-human ChEA Transcription Factor Binding Site Profiles 1.0 null SARS-dORF6_96Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.71665 Perturb_89_KO_SNORD74_ERP116971 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.01988 Breast Neoplasms CTD Gene-Disease Associations 1.0 1.3228 FEZF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 66.2642 STX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20904 KA-92-WY22_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.269672 POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FC-13-VS25_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.640162 TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLK Kinase Library Serine Threonine Kinome Atlas 1.0 null lymphomagenesis GeneRIF Biological Term Annotations 1.0 null K2 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE145990_1_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null K562_Fulvestrant_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0164427 midbrain reticular formation Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08822 Lung squamous cell carcinoma_LUSC_TCGA-39-5037-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC5031867-mmc2.xlsx-RYTTCCTG_V_ETS2_B-GENE_SYMBOL_ETS2 Rummagene Transcription Factor Associations 2026 1.0 null Ventral part of the lateral geniculate complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.57283 TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-REY6-0626-SM-2TF4G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15862 HUT-78 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.625 cytosolic small ribosomal subunit GO Cellular Component Annotations 2015 1.0 null rates GeneRIF Biological Term Annotations 1.0 null GSE228106_0_v_5_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GM12878 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.39121 GTEX-X261-0011-R7A-SM-4E3JJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43077 PMC11769652-EHF2-12-250-s001.xlsx-Sheet1-ZEB1_ZEB1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null spanning component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.219265 Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I5-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MXRA8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15722 BRD-K63189715 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3066 Urinary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.158 7453_RPL26_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.528527 GTEX-QMR6-1326-SM-32PLB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.844174 Lung adenocarcinoma_LUAD_TCGA-64-1678-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE172295_3_v_2_sh3gl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null 1165_CAMKK2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.567498 BRD-K25649596 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27866 K562_Entacapone_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0175936 CRCGN016_MCF10A.WT.HP_24H:P22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.96345 SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null UW228 DepMap CRISPR Gene Dependency 1.0 4.14077 Perturb_2353_KD_FOXD4L6_SRP072302 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.20469 POLR2A ENCODE Transcription Factor Targets 1.0 null CREB1 ChEA Transcription Factor Targets 1.0 null CRCGN009_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.60519 GSE140607_3_v_6_pioglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null deep layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.72677 H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR Rummagene Transcription Factor Associations 2026 1.0 null TEAD4 ENCODE Transcription Factor Targets 1.0 null mesomere 2 (preisthmus or caudal midbrain) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00163 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.95633 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040804 GTEX-U4B1-1026-SM-4DXT1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2211 BFTC-905 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.924552 GSE125007,GSE125008_10_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null 9971_ZBTB14_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.506285 primary motor cortex (area M1, area 4)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.98154 POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nuclear GeneRIF Biological Term Annotations 1.0 null GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.941919 BRD-K47762331 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62559 BRD-K01754917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72202 cellular response to dna damage stimulus GO Biological Process Annotations 2015 1.0 null hsa-miR-371-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.047969 dorsolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.4777 PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S05_LF_C2_3h-Unnamed_5_LTF Rummagene Transcription Factor Associations 2026 1.0 null muscular system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ETS1-20019798-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null MTA3 ENCODE Transcription Factor Targets 1.0 null GABPA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K47049026 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44496 GSE211286_4_v_5_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XOTO-0526-SM-4B662 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22197 BRD-K83845379 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19375 dactinomycin_mus musculus_gpl1261_wild type_gds2456 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-NL3H-0011-R11A-SM-2I3E6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.868259 GTEX-UPJH-0001-SM-3NMDE GTEx Tissue Sample Gene Expression Profiles 1.0 2.02353 SKIC3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00328018 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.47408 Dlx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 13.624 PMC12289921-41467_2025_62099_MOESM4_ESM.xlsx-MI-2-80-Gene_Symbol_MITF Rummagene Transcription Factor Associations 2026 1.0 null HEPG2 BioGPS Cell Line Gene Expression Profiles -1.0 -0.956144 GTEX-TKQ2-0004-SM-3NMAC GTEx Tissue Sample Gene Expression Profiles 1.0 1.78886 GTF2E1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2398 SOX2-16153702-HESC-human ChEA Transcription Factor Binding Site Profiles 1.0 null RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RR-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039563 TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null molecular_function GO Molecular Function Annotations 2015 1.0 null TATDN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0301 PRRX2 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K27889081 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12753 PITX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7471 CCL21 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00621688 H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-384 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GTEX-X585-0011-R8A-SM-46MUX GTEx Tissue Sample Gene Expression Profiles 1.0 1.42133 HT-55 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.939117 intrinsic component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.098814 CHL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00028 HCC89 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08668 GTEX-XOT4-0526-SM-4B66O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24828 abducens motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.85642 nucleic acid-templated transcription GO Biological Process Annotations 2015 1.0 null 7505_RPS16_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.716855 BRD-K07839394 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24503 BRD-K10638173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00353 GTEX-RUSQ-0226-SM-47JWT GTEx Tissue Sample Gene Expression Profiles 1.0 1.33699 Atrophy CTD Gene-Disease Associations 1.0 1.10734 intracellular part LOCATE Curated Protein Localization Annotations 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29T-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 5869_NUDT21_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.526422 HCFC1 ENCODE Transcription Factor Targets 1.0 null BRD-K20722478 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26025 GSE57871_6_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN009_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4008 yap1_18413746_mcf10a_gof_human_gpl570_gds3220 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.634681 cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.94539 resistance GeneRIF Biological Term Annotations 1.0 null CRCGN015_MCF10A_48H:A13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1603 cerebellar cortex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00044 inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.876272 cuneate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.18902 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NF-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 5750_NOP58_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.509855 H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CUX1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null 9210_TPP2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.534112 GTEX-TMMY-1026-SM-4DXTI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00994 GTEX-QMRM-0926-SM-447BR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15218 GTEX-RVPU-2426-SM-2XCAR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16912 GTEX-U3ZG-0001-SM-47JYF GTEx Tissue Sample Gene Expression Profiles 1.0 1.1912 BRD-K52428486 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15319 GTEX-XV7Q-1526-SM-4BRWB GTEx Tissue Sample Gene Expression Profiles 1.0 1.12566 GTEX-N7MS-0008-SM-4E3JI GTEx Tissue Sample Gene Expression Profiles 1.0 1.77442 GABPA_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE227891_5_v_0_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.973519 SIHA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.69382 superficial stratum of RtC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43461 GSE108614,GSE108615_3_v_2_setd1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null ribosome disassembly GO Biological Process Annotations 2015 1.0 null VZ in subcallosal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.10456 Small ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.807 MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:P02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0101 SIRT6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Anemia CTD Gene-Disease Associations 1.0 1.20493 GSE209911_0_v_1_ncstn_human RummaGEO Gene Perturbation Signatures 1.0 null ATF3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XAJ8-1026-SM-47JY9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0963 GTEX-NPJ8-1926-SM-3MJGB GTEx Tissue Sample Gene Expression Profiles 1.0 1.13229 skeletal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.411251 rna metabolic process GO Biological Process Annotations 2015 1.0 null regulation of rna biosynthetic process GO Biological Process Annotations 2015 1.0 null CRCGN015_MCF10A_48H:J24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.72585 MFE280 CCLE Cell Line Gene CNV Profiles -1.0 -1.86449 Medial preoptic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.84552 GSE113734_1_v_0_qprt_human RummaGEO Gene Perturbation Signatures -1.0 null ribosome disassembly GO Biological Process Annotations 2023 1.0 null Neurosphere_Cultured_Cells_Ganglionic_Eminence_Derived Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.16276 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ACTL6A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00430164 BRD-K27248268 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.01442 hsa-miR-515-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.020071 RELA_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPL-1626-SM-2HMIR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10097 SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WEY5-0526-SM-3GIKZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.904355 Bronchial epithelial cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.21 BRD-K56301498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13186 EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.514637 GTEX-T6MN-0011-R10A-SM-32QP7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.938359 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.754 CRCGN016_MCF10A.WT.HP_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.7688 Prostate Carcinoma DisGeNET Gene-Disease Associations 1.0 null Cytosolic large ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.989 primary motor cortex (area M1, area 4)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05933 SPI1-23547873-NB4-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K54879095 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45994 GSE169205_3_v_8_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null Vermiform appendix TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.276 H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WOFM-0005-SM-3MJF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.92559 Cytosolic ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.022 NCIH1155 DepMap CRISPR Gene Dependency 1.0 2.75712 GSE239844_7_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN017_MCF10A.TP53.M_24H:I10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.7529 CREB1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Carcinogenesis DisGeNET Gene-Phenotype Associations 1.0 null FOXC1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.6305 BRD-K59006776 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37183 Channelopathies DisGeNET Gene-Disease Associations 1.0 null POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEF2D_KD_GDS4759_339_mouse_E16 primary cortical neuron cultures GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FXR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3111 reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 starvation GeneRIF Biological Term Annotations 1.0 null NCIH2286 DepMap CRISPR Gene Dependency 1.0 5.00106 superficial stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48361 GTEX-XOTO-2926-SM-4B65G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02257 H2BK120ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HESX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20324 H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein-RNA complex assembly GO Biological Process Annotations 2025 1.0 null S0-EE-WJKI_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.212306 Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78L-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00094 cellular process GO Biological Process Annotations 2015 1.0 null GSE98898_7_v_1_hoxa1_human RummaGEO Gene Perturbation Signatures -1.0 null ES2 CCLE Cell Line Gene CNV Profiles -1.0 -1.41641 TA-34-CK62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.26283 ATF2 ENCODE Transcription Factor Targets 1.0 null GTEX-XOTO-0011-R9A-SM-4GICI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1733 POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF3-23680149-GBM1-GSC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.08736 SIX5 ENCODE Transcription Factor Targets 1.0 null PMC4905481-oncotarget-07-11397-s003.xlsx-Pinin_KD-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null r4 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43676 Sarcoma_SARC_TCGA-X6-A7W8-01A-21R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AE-53-IJ74_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.325789 H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null periventricular stratum of APal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16735 CRCGN013_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.65671 BRD-K82910696 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44352 ChIP_NANOG_18692474 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null hsa-miR-549 TargetScan Predicted Conserved microRNA Targets 1.0 0.009975 NANOG-18347094-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.61005 SIRT6 ENCODE Transcription Factor Targets 1.0 null GTEX-UPJH-0726-SM-4IHJW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.986017 cd4.Tcell BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.21876 Sense organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07736 RPE1SS48 DepMap CRISPR Gene Dependency 1.0 4.49498 GTEX-XYKS-1526-SM-4BRUP GTEx Tissue Sample Gene Expression Profiles 1.0 0.994266 Obesity DisGeNET Gene-Disease Associations 1.0 null BRD-K73391462 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56 regulation of cell proliferation GO Biological Process Annotations 2015 1.0 null Translation preinitiation complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.666 SOX5 JASPAR Predicted Transcription Factor Targets 1.0 null H3K9ac_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF143 ENCODE Transcription Factor Targets 1.0 null CRCGN016_MCF10A.TP53.M_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.5758 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EM-01A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 5747_NOP16_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.514086 HCC2429 DepMap CRISPR Gene Dependency 1.0 3.49521 BRD-K56283394 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73443 BRD-K73942403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44053 integral component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.17141 Central Neuroblastoma DisGeNET Gene-Disease Associations 1.0 null Precommissural nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.48373 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.75813 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AF-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.28919 vitamin c_mus musculus_gpl1261_gse37676 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null motor nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.8883 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051731 positive regulation of cellular process GO Biological Process Annotations 2015 1.0 null BRD-K00401259 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.95853 CRCGN008_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.1099 AtrioventricularNode BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.20904 pallidal septum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34704 BRD-K09721867 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26547 CRCGN017_MCF10A.WT.HP_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.42465 SPI1 ENCODE Transcription Factor Targets 1.0 null POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null using GeneRIF Biological Term Annotations 1.0 null BRD-K25312635 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13376 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Choroid plexus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.314 PMC6853299-pbio.3000476.s011.xlsx-Fig_4A-RA_812_genes_expression_ratio_in_ZF_and_OF_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NPJ7-2926-SM-3MJGQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.43598 PHOX2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 74.2914 CREB1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AA-86-YY62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.310535 CRCGN015_MCF10A.TP53.M_24H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.06715 3086_FIP1L1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.564172 inferior olive, medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.99315 embryoday10.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.875218 POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:K18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.41095 NCIH1694 CCLE Cell Line Gene Expression Profiles 1.0 1.68687 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6ES-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN013_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.58755 GSE125014_6_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MLX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.5855 H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null lactate GeneRIF Biological Term Annotations 1.0 null ovary GTEx Tissue Gene Expression Profiles -1.0 -1.04139 EP300_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9307 CC-61-HH09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.341528 GTEX-T6MN-0526-SM-32PMS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.958283 BRD-K56075657 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1898 GSE214596,GSE214598_1_v_2_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A6E4-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PML_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZH-1626-SM-2HMKI GTEx Tissue Sample Gene Expression Profiles -1.0 -2.00811 SGCB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10846 TAF1_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FBXO22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0434 A-Vietnam-1203_CIP048_RG4-2004(H5N1)HAAvirmut_7day-MOI-10^4_None_GSE37572 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.72984 GSE110524_2_v_5_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-RU72-0011-R7A-SM-2TF5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04116 COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.853759 BRD-K81465091 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40521 Perturb_15455_KD_E2F1_SRP165775 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.85789 GSE193258,GSE193259_9_v_3_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE133683_1_v_5_doxorubicin_mouse RummaGEO Drug Perturbation Signatures 1.0 null PMC8528285-pbio.3001085.s010.xlsx-Fig_7E-MAX_WT_TESTES_MAX Rummagene Transcription Factor Associations 2026 1.0 null striatum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.68157 renal tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.067821 K562_Tranylcypromine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0173377 ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.38742 GSE140322_3_v_1_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.58851 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Lateral dorsal nucleus of thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19644 hsa-miR-421 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18825 GSE258991_1_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null TAF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28881 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LV-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158834_7_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GALK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00726567 GSE221327_10_v_11_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K73290515 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03777 BRD-K50171760 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25797 ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOXC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69085 TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_PJ34_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.015684 GTEX-X585-0011-R10A-SM-46MUY GTEx Tissue Sample Gene Expression Profiles 1.0 1.03404 BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.1757 rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.985584 GSE123638,GSE123639_0_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null brown adipose tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.162421 GSE180185_4_v_1_setbp1_human RummaGEO Gene Perturbation Signatures -1.0 null 14737219-CSRgenes GeneSigDB Published Gene Signatures 1.0 null TE-10 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.58373 TRIM28 ENCODE Transcription Factor Targets 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.33651 subthalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.16957 496100408_PCx_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.11055 GTEX-XYKS-1326-SM-4BRUN GTEx Tissue Sample Gene Expression Profiles 1.0 0.895273 GSE134375_4_v_5_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QMR6-0011-R7A-SM-32PKL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27915 ZNF136 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.4923 POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-REY6-0326-SM-2TF5A GTEx Tissue Sample Gene Expression Profiles -1.0 -0.985483 BRD-A73909368_-666_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 188.641 BT474 Achilles Cell Line Gene Essentiality Profiles 1.0 1.57361 H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S4P3-1626-SM-3K2AZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826701 RKN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.901052 GSE193258,GSE193259_5_v_1_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null rostral migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.864767 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K08247496 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52581 Perturb_9957_KD_SNRNP200_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.46813 CRCGN014_HEPG2_24H:J18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.8662 TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8105-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K70532227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08017 CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LD-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null hsa-miR-4668-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.020071 ETS1 ENCODE Transcription Factor Targets 1.0 null CRCGN008_HEPG2_24H:L15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.44025 Aortic Aneurysm DisGeNET Gene-Disease Associations 1.0 null abducens nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.81753 SOX2-18358816-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-R55D-0008-SM-48FEV GTEx Tissue Sample Gene Expression Profiles 1.0 1.10619 NUGGC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00662386 CRCGN014_HEPG2_3H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.27404 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5196-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE222574_0_v_2_lmna_mouse RummaGEO Gene Perturbation Signatures -1.0 null orbital frontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06583 TAF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of POH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00163 BRD-K90163297 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8631 H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.941086 Perturb_2793_KD_PRMT1_SRP214436 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.64474 POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE88819_11_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Large intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.243 H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Childhood Non-Hodgkin Lymphoma DisGeNET Gene-Disease Associations 1.0 null GSE111247_2_v_13_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A71833059 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25935 GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64836 SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.69216 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.9482 POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FE-56-PV35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.576398 GTEX-XUJ4-0004-SM-4BOQE GTEx Tissue Sample Gene Expression Profiles 1.0 2.05931 TAF1_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K50938873 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11901 BRD-K50278697 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08416 POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NFK9-0006-SM-3GACS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.901218 ribosome binding GO Molecular Function Annotations 2025 1.0 null GTEX-W5X1-2526-SM-3GILC GTEx Tissue Sample Gene Expression Profiles 1.0 0.839906 ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K67022703 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49462 CRCGN017_MCF10A.WT.HP_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.39125 DLG2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00671213 H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -3.23388 Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NPJ7-0008-SM-4E3JS GTEx Tissue Sample Gene Expression Profiles 1.0 1.25784 CRCGN014_HEPG2_3H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.58075 targets GeneRIF Biological Term Annotations 1.0 null RPL24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39705 Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null DMS114 CCLE Cell Line Gene CNV Profiles -1.0 -1.33809 GTEX-R3RS-0005-SM-3GAEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26656 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9174882-EMMM-14-e15816-s004.xlsx-MYC_GeneSigs-KIM_MYC_AMPLIFICATION_TARGETS_UP_MYC Rummagene Transcription Factor Associations 2026 1.0 null endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051519 IB-33-TE51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.244019 GTEX-WHSE-0006-SM-3NMBW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78227 BRD-K29415052_NVP-BGT226_PC3_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.785252 Necrosis CTD Gene-Disease Associations 1.0 1.77433 GTEX-XQ3S-0001-SM-4B64K GTEx Tissue Sample Gene Expression Profiles 1.0 1.50751 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -2.47483 result GeneRIF Biological Term Annotations 1.0 null small ribosomal subunit GO Cellular Component Annotations 2015 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-5258-01A-01R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-A67R-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JHOS4 CCLE Cell Line Gene CNV Profiles -1.0 -1.41188 DOTC24510 DepMap CRISPR Gene Dependency 1.0 3.58265 JUN-27471255-CHONDROCYTES-MOUSE-RIB ChEA Transcription Factor Targets 2022 1.0 null GSE166004_1_v_0_pld1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K24108193 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04323 Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.401 H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null oocyte BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.73431 BRD-K03476091 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07439 Tumor Angiogenesis DisGeNET Gene-Phenotype Associations 1.0 null Midline group of the dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00163 PMC12234789-41467_2025_61560_MOESM3_ESM.xlsx-Supplementary_data_1-Only_YY1_IP-MS_YY1 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-4719 TargetScan Predicted Conserved microRNA Targets 1.0 0.002088 PMC6543837-Table_9.XLSX-In_vivo_M2_LPS--Supplementary_Table_9_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-P4QS-1626-SM-2S1NH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40285 H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.857444 PMC6326667__F5 PFOCR Pathway Figure Associations 2024 1.0 null GTEX-NPJ8-0011-R11A-SM-2YUMS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74126 MEIS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35504 BRD-K62085719 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33636 BRD-K65392756 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01893 Duodenum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.252 5735_NOL6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.677094 GABPA_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4801 TargetScan Predicted Conserved microRNA Targets 1.0 0.015875 BRD-K79147587 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05889 tonsil_8a1 HPA Tissue Sample Gene Expression Profiles 1.0 2.49573 hsa-miR-198 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 cerebellar cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.96169 BRD-K48935217_S1364_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_5_TbID_-biotin_ERM_proteo-Gene_Name_ETV5 Rummagene Transcription Factor Associations 2026 1.0 null dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.864312 hsa-miR-198 TargetScan Predicted Conserved microRNA Targets 1.0 0.059817 FA-80-DR66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.425393 hsa-miR-320b TargetScan Predicted Conserved microRNA Targets 1.0 0.047969 NFATC1 ENCODE Transcription Factor Targets 1.0 null promoter GeneRIF Biological Term Annotations 1.0 null ATP6V0E2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13077 7454_RPL27A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.06858 BRD-K30351863_NCGC00185090-03_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Ovary BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.33841 CDK1 PhosphoSitePlus Substrates of Kinases 1.0 null H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZBTB33_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:F20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3503 Perturb_7627_KD_HNRNPL_SRP129007 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.63235 Aa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.947 GTEX-T6MN-0426-SM-32PMF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.932225 Ketosis DisGeNET Gene-Disease Associations 1.0 null GSE145249_1_v_2_ppm1g_human RummaGEO Gene Perturbation Signatures 1.0 null K562_MK-5108_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0190916 GSE172146_2_v_1_mettl1_human RummaGEO Gene Perturbation Signatures 1.0 null intermediate stratum of r10BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17308 ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XOTO-0011-R7B-SM-4B64R GTEx Tissue Sample Gene Expression Profiles -1.0 -0.845142 GSE119978,GSE180930_6_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null BB-20-UU03_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.307138 BRD-K02315086 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01649 GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40951 NCIH1648 CCLE Cell Line Gene CNV Profiles 1.0 1.38767 BRD-K69932463_AZD-8055_HS578T_3_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RB-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K24525269 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30467 Perturb_15109_KD_MPP8_SRP218207 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.82501 KAT2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.17236 Rarg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 49.3419 GTEX-NFK9-0008-SM-4E3JE GTEx Tissue Sample Gene Expression Profiles 1.0 1.14275 GTEX-WZTO-0011-R4A-SM-3NMC7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.828579 GTEX-O5YU-0008-SM-4E3I7 GTEx Tissue Sample Gene Expression Profiles 1.0 2.42723 H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CHD2 ENCODE Transcription Factor Targets 1.0 null DF-00-DK69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.283556 membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 active-transport-cell-nucleus Phosphosite Textmining Biological Term Annotations 1.0 null H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Adult Non-Hodgkin Lymphoma DisGeNET Gene-Disease Associations 1.0 null 2124_DDX47_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.568992 hsa-miR-3150a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 r10 part of basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1712 HS578T CCLE Cell Line Gene Expression Profiles -1.0 -1.74814 hsa-miR-4261 TargetScan Predicted Conserved microRNA Targets 1.0 0.026857 Messenger ribonucleoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.885 POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.383 CRCGN009_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.08041 PMC3680531-cc-12-1510-s02.pdf-35-CREB3L1_CREB3L1 Rummagene Transcription Factor Associations 2026 1.0 null H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55F-1226-SM-2TF59 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14966 striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.25155 Lhx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 37.1 SHP77 DepMap CRISPR Gene Dependency 1.0 2.42569 outer SZ in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.972047 Urinary bladder cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.107 23132/87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.30056 stratum lacunosum-moleculare of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05387 Chronic Lymphocytic Leukemia DisGeNET Gene-Disease Associations 1.0 null Perturb_4541_KD_Baz2a_SRP126769 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.44204 NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24881 UTP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16991 ChIP_ZFP281_18358816 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_pancreas_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Edema CTD Gene-Disease Associations 1.0 1.07199 H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.32542 TBP ENCODE Transcription Factor Targets 1.0 null H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LOX-IMVI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.64458 GTEX-TMZS-0001-SM-3P61Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.29001 BRD-A61778798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.898 excretory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052051 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.914379 GSE125007,GSE125008_6_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null posteroventral (inferior) parietal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.924826 EW8 CCLE Cell Line Gene Expression Profiles -1.0 -1.60522 cell part GO Cellular Component Annotations 2015 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SP-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNOS-0003-SM-3NMAO GTEx Tissue Sample Gene Expression Profiles 1.0 1.44641 YWHAE Pathway Commons Protein-Protein Interactions 1.0 null PMPCA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00423895 H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CD4_Memory_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.19467 CI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00963 posteroventral (inferior) parietal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.852639 H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cerebellar cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.28272 GTEX-PWOO-1326-SM-48TCJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.11448 FARAGE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.833474 hsa-miR-4725-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.006367 processes GeneRIF Biological Term Annotations 1.0 null BRD-K04192407 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65375 primary auditory cortex (core)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.959825 SAFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12149 HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.302 C3orf52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08877 GTEX-PLZ5-0326-SM-3P614 GTEx Tissue Sample Gene Expression Profiles 1.0 0.857188 A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54396 CRCGN017_MCF10A.WT.HP_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0603 Perturb_10787_KO_Shp_SRP220815 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.18744 7516_RPS27A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.592356 GSE195559_8_v_5_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null formation of translation preinitiation complex GO Biological Process Annotations 2023 1.0 null BRD-K23857235 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0294 TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null protection GeneRIF Biological Term Annotations 1.0 null MAX ENCODE Transcription Factor Targets 1.0 null PMC12823428-43587_2025_1018_MOESM3_ESM.xlsx-ST12-Supplementary_Table_12_Main_mendelian_randomisation_results_of_plasma_proteins_on_delirium_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null 7723_SDHAF1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.552899 GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03401 4911_MCTS1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -1.09276 GSE239844_7_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null WiDr cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.052 motor nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.09205 PML_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4749-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A40E-01A-12R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3545-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.026857 PBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2222 TAF1_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7477_RPL7A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.583739 GSE158834_7_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19876 GTEX-QVUS-0226-SM-3GIJY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05445 GC-04-UF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.783416 pontine raphe nucleus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05024 GTEX-WWYW-0005-SM-3NB3K GTEx Tissue Sample Gene Expression Profiles -1.0 -0.890739 PA-75-VL17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.991718 Anterior cingulate area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40058 GSE142019,GSE142021_1_v_3_ythdf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.18955 H3K4me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CC-03-PW00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.282219 regulation of cellular process GO Biological Process Annotations 2015 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D9-A4Z5-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null HDAC1 ENCODE Transcription Factor Targets 1.0 null GTEX-U3ZM-0002-SM-3NMDM GTEx Tissue Sample Gene Expression Profiles 1.0 1.49518 Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.076 Colonic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.057 BRD-K53903639_480743.cdx_WSUDLCL2_6.0_h_80.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN015_MCF10A.TP53.M_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.92445 CRCGN015_MCF10A_48H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.74848 BRD-K72866723 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.45421 CRCGN013_HEPG2_24H:K04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.65588 Leukemia_promyelocytic-HL-60 BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.976889 Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.88463 PA-TU-8988T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.36424 BRD-K75413392 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15785 GSE103122_0_v_1_puromycin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 Tumor Progression DisGeNET Gene-Phenotype Associations 1.0 null GSE146982_7_v_1_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.97927 H3K4me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:F17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1961 HSC-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.237 FC-64-QJ96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.342297 H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null MYC ENCODE Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K36134264 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48626 NR2F2 ENCODE Transcription Factor Targets 1.0 null CRCGN017_MCF10A.TP53.M_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.0441 CRCGN015_MCF10A_48H:F01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.9727 SNU719 CCLE Cell Line Gene Expression Profiles -1.0 -1.55008 Invasive Ductal Breast Carcinoma DisGeNET Gene-Disease Associations 1.0 null PMC7708794-mmc2.xlsx-DGE_table_Imm-high_vs_Imm-low-TFT_TBXT Rummagene Transcription Factor Associations 2026 1.0 null MIA PACA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.842235 PHOX2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 75.9363 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.962686 hsa-miR-4766-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.029271 COLO-818 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00028 Dorsal motor nucleus of the vagus nerve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76217 preoptic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46377 GB-06-BA49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.229956 A4FUK CCLE Cell Line Gene Expression Profiles 1.0 1.51027 IALM CCLE Cell Line Gene CNV Profiles 1.0 1.35081 OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23169 Sarcoma_SARC_TCGA-JV-A5VF-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA1 ENCODE Transcription Factor Targets 1.0 null H3K9ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K56261053 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43797 10139_ZMAT5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.516489 CRCGN010_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.8915 GA-28-SS67_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.318081 ATP2A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.42736 SDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05276 HD-51-KD29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.530692 GSE60837_0_v_3_bcl9_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:K12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.27875 DAUDI cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.736 BRD-K96596828 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03239 Malignant Neoplasm DisGeNET Gene-Disease Associations 1.0 null m1 part of parabrachialis pigmentosus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.93862 nih3t3 Phosphosite Textmining Biological Term Annotations 1.0 null superficial layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.903077 BRD-K81199760 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91198 H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPJH-0006-SM-3GACW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.890067 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A23K-01A-11R-A16R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE239844_1_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE129241_4_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE202434,GSE202438_6_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null 2544_EIF3A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.565585 liminal part of the r10 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07 PRMT2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00515884 BRD-K07762528 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33047 BRD-K67813189 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78042 KURAMOCHI CCLE Cell Line Gene Expression Profiles -1.0 -1.59555 HTC-C3 GDSC Cell Line Gene Expression Profiles 1.0 1.7036 BRD-K21327356 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18455 3t3-cells Phosphosite Textmining Biological Term Annotations 1.0 null TDOTT DepMap CRISPR Gene Dependency 1.0 5.99844 AE-56-SL06_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.488157 BRD-K14359826 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56227 K562_Sorafenib Tosylate_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0217957 GTEX-WFJO-1926-SM-3GILA GTEx Tissue Sample Gene Expression Profiles 1.0 0.86055 GSE185944_2_v_3_pth1r_mouse RummaGEO Gene Perturbation Signatures -1.0 null ELK1-19687146-Hela cells-human ChEA Transcription Factor Binding Site Profiles 1.0 null 3869_HNRNPK_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.554356 EA-39-YN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.26405 primary metabolic process GO Biological Process Annotations 2015 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-2V-A95S-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Satellite glial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.534 Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.341 GTEX-T6MN-0005-SM-32PLJ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.37629 testis_7e HPA Tissue Sample Gene Expression Profiles -1.0 -2.39394 primary motor cortex (area M1, area 4)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08367 drug GeneRIF Biological Term Annotations 1.0 null abnormal eye morphology IMPC Knockout Mouse Phenotypes 1.0 null pregeniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14123 NCIH2052 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.15853 outer CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.87597 CBX3 ENCODE Transcription Factor Targets 1.0 null BRD-K51535480 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08637 Liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.056 ELK1-19687146-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SPEG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03206 LN18 BioGPS Cell Line Gene Expression Profiles 1.0 0.873971 RELA ENCODE Transcription Factor Targets 1.0 null GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55396 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null K562_RG108_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0160604 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MAPK3 PhosphoSitePlus Substrates of Kinases 1.0 null Perturb_15110_KD_PPHLN1_SRP218207 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.41399 Head and neck cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.268 hsa-miR-4653-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.008128 related GeneRIF Biological Term Annotations 1.0 null doxorubicin_homo sapiens_gpl6947_gse25741 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hematologic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.277584 BRD-K64425085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32649 USP2_KO_GSE43517_20_mouse_kidney GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null A-CA-04-2009(H1N1)_12Hour_None_GSE37571 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.44778 GSE163240_3_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null r6 part of the basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0404 BRD-K55606442 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03718 Parkinson Disease DisGeNET Gene-Disease Associations 1.0 null bone cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null cellular biosynthetic process GO Biological Process Annotations 2015 1.0 null K562 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.943 GSE253056_0_v_1_erythropoietin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE201668_0_v_1_ncor2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K53953065 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09868 ADORA2B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00757251 PMC3680531-cc-12-1510-s01.pdf-32-CREB3L1_CREB3L1 Rummagene Transcription Factor Associations 2026 1.0 null reuniens nucleus, main part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18744 496100339_HIP_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.50395 primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.53047 BT20 CCLE Cell Line Gene CNV Profiles 1.0 2.05288 BRD-K55853030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56891 ERG-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE200352_4_v_8_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN008_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.6472 TCF7L2-21901280-H4IIE-RAT ChEA Transcription Factor Targets 2022 1.0 null 15735024-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null positive regulation of cell population proliferation GO Biological Process Annotations 2023 1.0 null CRCGN012_HEPG2_24H:D08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.47947 7525_RPS3_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.628618 Liver Neoplasms CTD Gene-Disease Associations 1.0 1.52693 POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-224 TargetScan Predicted Conserved microRNA Targets 1.0 0.008128 H3K4me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K88670720 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19175 Dom34-Hbs1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.658 BRD-K00411149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11572 MYEOV LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00665452 BRD-K14394756 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4027 brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K47878187 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43537 MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.1052 ACHN Achilles Cell Line Gene Essentiality Profiles -1.0 -1.20413 Synaptic vesicle, readily releasable pool COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.896 PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TKQ1-1426-SM-4GICK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64684 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.971447 BRD-K24025166 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05966 GSE211983_1_v_3_nicotine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-NPJ8-0011-R7a-SM-2HMJV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.875996 YD-49-HM53_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.329903 GTEX-S32W-0126-SM-4AD61 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28187 hsa-miR-4659b-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CF-65-GU65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.90679 BRD-K43603649 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14237 hsa-miR-127-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 METTL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11768 BRD-K67261586 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81872 BRD-K76616863 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03358 mantle zone of r10BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17308 PUA-like domain InterPro Predicted Protein Domain Annotations 1.0 null H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN013_HEPG2_24H:I14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.11057 GSE166914_1_v_0_abemaciclib_human RummaGEO Drug Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.94927 POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:O13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.75524 cisplatin_mus musculus_gpl339_gds3099 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.07853 cellular macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521 Rummagene Transcription Factor Associations 2026 1.0 null CREB1-23762244-HIPPOCAMPUS-RAT ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K24815102 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33825 H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DPP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02705 RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null stratum pyramidale of caudal CA3 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.854606 H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Finnish type amyloidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.244 cellular component assembly GO Biological Process Annotations 2015 1.0 null SC-8023 (IFI16) NURSA Protein Complexes 1.0 null GTEX-X8HC-0526-SM-4E3JA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11626 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H2-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null XRN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00772511 HEC1B CCLE Cell Line Gene Expression Profiles -1.0 -2.10159 7513_RPS24_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.581454 7536_RPS6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.782604 CRCGN017_MCF10A.WT.HP_24H:N03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.02416 SIN3A ENCODE Transcription Factor Targets 1.0 null hsa-miR-4291 TargetScan Predicted Conserved microRNA Targets 1.0 0.361556 GSE139455_7_v_3_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null H3K27ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I2-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN012_HEPG2_24H:J19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.61294 BRD-U29336476_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE165548_2_v_8_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null Frontal pole, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1809 Gastric Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.832671 Perturb_11276_KO_Dicer_SRP041679 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GTEX-QDT8-0008-SM-48U2F GTEx Tissue Sample Gene Expression Profiles 1.0 0.899072 GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1442 MCC13 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K94082609 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35669 cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.246799 nucleic acid metabolic process GO Biological Process Annotations 2015 1.0 null GSE157684,GSE173391_0_v_1_rgcc_human RummaGEO Gene Perturbation Signatures 1.0 null WC-09-GD62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.683737 GSE248883_0_v_1_shmt2_mouse RummaGEO Gene Perturbation Signatures 1.0 null LTF MotifMap Predicted Transcription Factor Targets 1.0 null Fast muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.055 H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K32000549 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.19916 tumorigenesis GeneRIF Biological Term Annotations 1.0 null BRD-K71265179_Carbazol-9-yl-p-tolyl-methanone_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8094-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Inflammatory Pain DisGeNET Gene-Phenotype Associations 1.0 null A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_12Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 3.17021 Lung adenocarcinoma_LUAD_TCGA-55-A48Z-01A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K34798837 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59637 9818_WDR3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.512838 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-Row_names_CENPX Rummagene Transcription Factor Associations 2026 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AN-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.53 GTEX-XMK1-0001-SM-4B64F GTEx Tissue Sample Gene Expression Profiles 1.0 1.70077 SIN3A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.55076 GTEX-WCDI-0008-SM-47JYE GTEx Tissue Sample Gene Expression Profiles 1.0 1.57272 BRD-K39715006 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2198 NCI-H2052 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.841498 BRD-K23435841 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30193 LF-94-HB11_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.221223 MIER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31254 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4V-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE134029_3_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-35-5375-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-615-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.283838 ATF3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Protein kinase 5 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.932 CRCGN016_MCF10A.TP53.M_24H:A20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.02719 M059J GDSC Cell Line Gene Expression Profiles 1.0 1.5713 JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.839675 adipose tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.117446 EC-62-OE64_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.282666 bexarotene_homo sapiens_gpl96_gds2777 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FAM83D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25074 UBA1 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN008_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.0246 H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T2IS-0426-SM-32QPE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22638 Triple Negative Breast Neoplasms DisGeNET Gene-Disease Associations 1.0 null BRD-K42253676 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2546 hsa-miR-4741 TargetScan Predicted Conserved microRNA Targets 1.0 0.062888 BRD-K55187425_ON-01910_MCF7_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.842235 hsa-miR-3662 TargetScan Predicted Conserved microRNA Targets 1.0 0.050854 BRD-K71415389 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83922 icSARS CoV_0Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.37078 GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10046 BRD-K43108627 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04581 oppositions GeneRIF Biological Term Annotations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7325-01B-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JUN ENCODE Transcription Factor Targets 1.0 null Perturb_4759_KO_DLG2_SRP315088 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.62722 STAT5A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XQ3S-0006-SM-4BOQ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.63514 BRD-K69184209 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15214 PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-6_names_TP53 Rummagene Transcription Factor Associations 2026 1.0 null NANOG-16153702-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE193258,GSE193259_5_v_6_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null skeletal system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052458 DKMG Achilles Cell Line Gene Essentiality Profiles -1.0 -1.26172 hippocampus (hippocampal formation)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.44873 H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE206516,GSE206518_3_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XPT6-0008-SM-4B64Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.913001 H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null QE-79-XO29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.512378 HEC50B CCLE Cell Line Gene CNV Profiles 1.0 2.51199 GSE137702_2_v_1_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lef1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.3895 CREB1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U8T8-1426-SM-3DB9H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00631 H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Ebolavirus(EBOV)_7day_Splenocytes_19683682_GSE17509 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.52822 GTEX-OXRK-0008-SM-3NB28 GTEx Tissue Sample Gene Expression Profiles 1.0 1.81088 GSE119978,GSE180930_6_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45Q-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OCUM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20421 H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null CUX1-19635798-MULTIPLE HUMAN CANCER CELL TYPES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.07825 PTGER1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00544001 primary auditory cortex (core)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.17577 OACM51 DepMap CRISPR Gene Dependency 1.0 2.68778 incurable GeneRIF Biological Term Annotations 1.0 null single-organism process GO Biological Process Annotations 2015 1.0 null 8MGBA DepMap CRISPR Gene Dependency 1.0 2.51473 Paraventricular hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02132 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Polysome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.42 SW480 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.1299 outer SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.92444 RCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.68397 BRD-K78477132 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12739 MYC_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null regulation of cellular macromolecule biosynthetic process GO Biological Process Annotations 2015 1.0 null BRD-K56341841 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13504 regulation of cellular biosynthetic process GO Biological Process Annotations 2015 1.0 null EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Field CA3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33845 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 nucleus of the stria terminalis, medial division, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08139 organic cyclic compound binding GO Molecular Function Annotations 2015 1.0 null GSE70499_3_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NL3G-0008-SM-4E3JX GTEx Tissue Sample Gene Expression Profiles 1.0 2.43462 CRCGN015_MCF10A_48H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.3273 H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XLM4-0004-SM-4AT5I GTEx Tissue Sample Gene Expression Profiles 1.0 1.81166 ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.53561 CTCF-21964334-BJAB-B-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC9795333-mmc4.xlsx-HUES66_Ex_SATB2_c1_c4_c9-X-linked_genes_SATB2 Rummagene Transcription Factor Associations 2026 1.0 null CHD8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00612773 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WYVS-2326-SM-3NMAI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.979947 BRD-K42506600 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.82812 nucleic acid binding GO Molecular Function Annotations 2015 1.0 null GSE158834_7_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of PcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.29828 anterior pretectal nucleus, ventral superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48361 NF-21-HQ00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.212846 Primary somatosensory area, barrel field, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.84951 chlorambucil_homo sapiens_gpl570_gds2970 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051732 GSE229973_3_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A.WT.HP_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.09732 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-374c TargetScan Predicted Conserved microRNA Targets 1.0 0.026857 CCRT CEM BioGPS Cell Line Gene Expression Profiles -1.0 -1.19236 Carcinoma, Squamous Cell CTD Gene-Disease Associations 1.0 1.16533 H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.95814 GTEX-UJMC-1826-SM-3GADT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.864861 CRCGN013_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9531 GTEX-QEG5-0826-SM-2I5GF GTEx Tissue Sample Gene Expression Profiles 1.0 0.927995 preisthmic midbrain tectum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33079 STAT1 ENCODE Transcription Factor Targets 1.0 null DMS153 CCLE Cell Line Gene Expression Profiles 1.0 1.48414 ETS1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.856319 hsa-miR-1261 TargetScan Predicted Conserved microRNA Targets 1.0 0.003282 BARX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7319 ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.937112 ATF3-23680149-GBM1-GSC-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-18-3415-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ae2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.072 spleen GTEx Tissue Gene Expression Profiles 1.0 0.864639 GTEX-N7MS-2625-SM-3LK77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17204 NPTX2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00523483 BRD-K41396351 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27563 orbital frontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.47869 Lymphoblast TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.22 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.882298 kidney HPA Tissue Protein Expression Profiles 1.0 1.17767 GSE202434,GSE202438_13_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD4_druginhibition_224_GSE50865 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -3.27326 GTEX-XOTO-0006-SM-4B64T GTEx Tissue Sample Gene Expression Profiles -1.0 -2.52451 GSE131425_2_v_0_arg2_mouse RummaGEO Gene Perturbation Signatures 1.0 null medial group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.862354 DMS454 CCLE Cell Line Gene CNV Profiles -1.0 -2.20312 NFIC ENCODE Transcription Factor Targets 1.0 null GSE142210_9_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null EGR1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hmx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.1265 GTEX-OHPN-0011-R2A-SM-2I5FB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01034 SOX2-18692474-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE153871_4_v_3_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Colorectal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.244 GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1471 lymph node HPA Tissue Gene Expression Profiles 1.0 1.16105 7450_RPL23_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.579756 Squamous Cell Carcinoma Of Esophagus DisGeNET Gene-Disease Associations 1.0 null H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Six4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.2689 periventricular stratum of PO1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10527 Perturb_91_KO_SNORD77_ERP116971 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.30991 regulation of macromolecule biosynthetic process GO Biological Process Annotations 2015 1.0 null HUH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.21809 BRD-K38970027 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26646 hsa-miR-3672 TargetScan Predicted Conserved microRNA Targets 1.0 0.082179 H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.13123 limitans nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.870377 H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TBL1XR1 ENCODE Transcription Factor Targets 1.0 null SCC4 CCLE Cell Line Gene CNV Profiles 1.0 1.79464 BRD-K83336168_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE209973_1_v_0_glutamine_human RummaGEO Drug Perturbation Signatures -1.0 null EP300_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1283 GSE189609_1_v_0_hax1_human RummaGEO Gene Perturbation Signatures -1.0 null PPARD-21283829-MYOFIBROBLAST-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K73858940 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49367 IRF2 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K29392278 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02939 7449_RPL23A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.604921 hsa-miR-202 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 ADIPOR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14569 ATF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.7467 CRCGN012_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.19371 Perturb_61_KO_Usp16_SRP271781 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.99929 PAX8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4027 GTEX-OIZG-0008-SM-4E3J2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.60656 BD-38-QC39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.267934 GSE219195_0_v_2_rbm12_human RummaGEO Gene Perturbation Signatures 1.0 null oval paracentral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24278 hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.42122 7513_RPS24_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.561666 formation of translation preinitiation complex GO Biological Process Annotations 2015 1.0 null Heart Diseases CTD Gene-Disease Associations 1.0 1.43076 jurkat-cells Phosphosite Textmining Biological Term Annotations 1.0 null GTEX-UTHO-2926-SM-3P5Z9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.968598 hsa-miR-1236 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5VU-01A-21R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF12 ENCODE Transcription Factor Targets 1.0 null BRD-K36298208 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50062 primary auditory cortex (core)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08828 NOS2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.005753 cerebellar cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.46198 GSE149903_5_v_7_myd88_mouse RummaGEO Gene Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.907338 GATA3_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Paraventricular hypothalamic nucleus, magnocellular division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06447 SPI1 ChEA Transcription Factor Targets 1.0 null YY1 ENCODE Transcription Factor Targets 1.0 null GTEX-OHPK-0008-SM-4E3JL GTEx Tissue Sample Gene Expression Profiles 1.0 1.13725 H3K27ac_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.1845 C32TG Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24126 PTEN_KD_GDS4759_337_mouse_E16 primary cortical neuron cultures GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-XV7Q-0005-SM-4BRWI GTEx Tissue Sample Gene Expression Profiles 1.0 0.899305 PA-TU-8988S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.07254 increased total body fat amount MGI Mouse Phenotype Associations 2023 1.0 null skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.51377 PMC12169532-pone.0325700.s010.xlsx-Table_S4-Table_S4_List_of_genes_that_upon_knockdown_KD_led_to_transcriptional_signitures_similar_to_the_input_DEG_set_of_CRC_or_LIHC_and_their_KEGG_enrichment_AR Rummagene Transcription Factor Associations 2026 1.0 null CRCGN017_MCF10A.WT.HP_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.26895 BRD-K31013025 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31158 striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.939431 cellular macromolecular complex assembly GO Biological Process Annotations 2015 1.0 null lateral ventricle HPA Tissue Protein Expression Profiles 1.0 1.17767 cerebellar cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.922381 Medial septal complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16944 ELF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-561 TargetScan Predicted Conserved microRNA Targets 1.0 0.015875 Field CA3, stratum pyramidale Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3522 Burkitt Lymphoma DisGeNET Gene-Disease Associations 1.0 null MCRIP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64837 nucleobase-containing compound metabolic process GO Biological Process Annotations 2015 1.0 null LU65 CCLE Cell Line Gene Expression Profiles 1.0 2.19018 signifies GeneRIF Biological Term Annotations 1.0 null chrX_120603259_A_G_b38 GTEx eQTL 2025 1.0 1.72316 HMGB3 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K92565319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06528 hsa-miR-3134 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 GSE200388_0_v_1_gemin5_human RummaGEO Gene Perturbation Signatures -1.0 null regulation of nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null hsa-miR-4703-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.042355 ZNF558 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 117.853 OSBPL8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14263 BRD-K11258719 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9744 process GeneRIF Biological Term Annotations 1.0 null BRD-K06698399 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0284 hsa-miR-3149 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GTEX-QDVN-1326-SM-48TZ3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17413 bonemarrow_5a HPA Tissue Sample Gene Expression Profiles -1.0 -1.13932 SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null sense organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055394 BRD-K71357636 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22905 Perturb_2297_KD_MUC1_SRP214243 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.55343 cerebellar cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -3.55946 include GeneRIF Biological Term Annotations 1.0 null EP300_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT5A ENCODE Transcription Factor Targets 1.0 null CYP3A7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00703618 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE206516,GSE206518_2_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null intermediate stratum of PalSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30298 Fatty Liver CTD Gene-Disease Associations 1.0 1.51004 SISO DepMap CRISPR Gene Dependency 1.0 2.75375 GSE185944_5_v_1_pth1r_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE184892_7_v_5_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A.WT.HP_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.00942 SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null septodiagonal transition area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21543 GTEX-UTHO-1026-SM-3GAF7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.864877 Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RCCFG2 DepMap CRISPR Gene Dependency 1.0 2.85628 H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUYS-0002-SM-47JXL GTEx Tissue Sample Gene Expression Profiles 1.0 1.31142 Cyclin D1-CDK6 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.679 EP300_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CELF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00620235 Translation initiation complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.773 GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null supraoptic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.37039 ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.5241 Leukemogenesis DisGeNET Gene-Disease Associations 1.0 null POLR2A_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.900671 tretinoin_homo sapiens_gpl6244_gds4180 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HI-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K13076765 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0193 Colon cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.07 GTEX-NFK9-0526-SM-2YUNL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.862272 BRD-K33453127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70567 GTEX-Q2AI-1526-SM-3GIJ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21589 C2CD2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04446 POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR-8383 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.619 PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null 6-phosphofructokinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.784 TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1436 CCLE Cell Line Gene Expression Profiles 1.0 1.43719 macromolecular complex GO Cellular Component Annotations 2015 1.0 null IGFLR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09945 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Thyroid GTEx Tissue Gene Expression Profiles 2023 1.0 5.21304 GSE186647,GSE217288_11_v_7_hnrnpc_human RummaGEO Gene Perturbation Signatures -1.0 null Field CA3, stratum radiatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23742 GTEX-X4XX-2926-SM-3NMB1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.992478 GSE184892_7_v_3_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K41700289 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2889 GSE229671,GSE229673_3_v_1_yrdc_human RummaGEO Gene Perturbation Signatures -1.0 null ONECUT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.4847 XRCC5 MSigDB Cancer Gene Co-expression Modules 1.0 null H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AI-0826-SM-48TZO GTEx Tissue Sample Gene Expression Profiles 1.0 1.02777 GTEX-Q2AH-1826-SM-2S1Q2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.348 BRD-K92974694 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06654 NCIH3255 CCLE Cell Line Gene CNV Profiles 1.0 1.7254 BRD-K67090705 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.14915 PMC4149371-pone.0105180.s010.xls-SOX2-GENE_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GF-A6C9-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.8942 POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN010_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.93927 SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null LGE-VZ border region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.956372 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPI1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UF-06-JB00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.497152 H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary auditory cortex (core)_25 pcw_F_12948 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.907798 BRD-K40733000 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49719 GSE161295_4_v_1_cdk8_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE98898_8_v_1_hoxa1_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleus of the inferior collicular brachium, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51688 CRCGN017_MCF10A.TP53.M_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.01058 NCIH841 CCLE Cell Line Gene CNV Profiles -1.0 -1.76338 PDCD6IP Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A6E7-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 4270_KANSL1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.596565 Anterior hypothalamic nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.89125 BRCA1 ENCODE Transcription Factor Targets 1.0 null skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.36105 Lung adenocarcinoma_LUAD_TCGA-78-7163-01A-12R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_Mesna_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0182162 MCF7_ENMD-2076 L-Tartaric acid_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0106926 DNAJC5G LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00453735 superficial stratum of r9Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04279 hsa-miR-331-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Liver cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.134 organelle disassembly GO Biological Process Annotations 2025 1.0 null gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.132351 lateral part of alar m1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07499 GSE158834_7_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null PBX3 ENCODE Transcription Factor Targets 1.0 null recurrent GeneRIF Biological Term Annotations 1.0 null A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_18Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.84642 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.29955 ATF2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF354A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 136.107 H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC12824661-BLOOD_BLD-2024-027020-mmc6.xls-Table_S14-HES4_Down_HES4 Rummagene Transcription Factor Associations 2026 1.0 null primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.16848 7441_RPL17_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.982395 GSE242290_3_v_2_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AXIN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00392429 Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.429 Peripheral_Blood_Mononuclear_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.937528 Generalized Seizures DisGeNET Gene-Disease Associations 1.0 null Male reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.209 BE-81-QL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.318304 POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_2674_Mut_STAT5A_SRP303606 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.42113 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null positive regulation of cellular process GO Biological Process Annotations 2023 1.0 null Primary hematopoietic stem cells G-CSF-mobilized Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.41548 GTEX-POMQ-0826-SM-3P61H GTEx Tissue Sample Gene Expression Profiles 1.0 0.854962 KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.937112 organic cyclic compound biosynthetic process GO Biological Process Annotations 2015 1.0 null DNAJC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07952 GTEX-S95S-0002-SM-3NM8K GTEx Tissue Sample Gene Expression Profiles 1.0 2.02049 BRD-K94378105 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03708 GSE137177_2_v_0_folic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-186 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 GTEX-QV31-0726-SM-3GAEG GTEx Tissue Sample Gene Expression Profiles 1.0 0.841769 Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rhabdomyosarcoma GeneRIF Biological Term Annotations 1.0 null TFAP2A ChEA Transcription Factor Targets 1.0 null GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39886 cell cycle GO Biological Process Annotations 2015 1.0 null NF-21-HQ00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.338453 cytosol COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 COLO 800 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.68359 BRD-K70533557 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.26598 NCIH1573_LUNG CCLE Cell Line Proteomics 1.0 2.69481 hsa-miR-96 TargetScan Predicted Conserved microRNA Targets 1.0 0.026857 KMM1 CCLE Cell Line Gene CNV Profiles 1.0 1.33797 CRCGN008_HEPG2_24H:L14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.2327 GTEX-O5YT-1426-SM-3MJHC GTEx Tissue Sample Gene Expression Profiles 1.0 1.08407 BRD-K21355275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.1171 GSE153871_0_v_3_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-T2IS-0011-R5A-SM-32QP4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13757 H3K27ac_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8203-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE195663_0_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null brain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.22246 hsa-miR-30a TargetScan Predicted Conserved microRNA Targets 1.0 0.039622 LAMA-84 GDSC Cell Line Gene Expression Profiles -1.0 -1.55669 DoTc2-4510 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.02097 SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.28894 H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney Diseases CTD Gene-Disease Associations 1.0 1.11151 SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QMR6-0011-R11A-SM-32PKK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20722 ES-I3 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.982248 arcuate nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.86168 hsa-miR-3117-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.029271 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.241895 SPI1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE232624_4_v_5_ethanol_human RummaGEO Drug Perturbation Signatures -1.0 null ACE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5517 r5 part of ventral lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42213 metastasis GeneRIF Biological Term Annotations 1.0 null NCI-H1975 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.841498 CHLA10 DepMap CRISPR Gene Dependency 1.0 3.17914 BRD-K64001802 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12317 MDA MB435 BioGPS Cell Line Gene Expression Profiles 1.0 1.42786 BRD-K94858557 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21519 KDM5A ENCODE Transcription Factor Targets 1.0 null ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.38896 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4712-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 17660535-TableS4b GeneSigDB Published Gene Signatures 1.0 null OB-06-WW76_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.332844 Perturb_5103_KO_Ssrp1_SRP235595 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.84533 GTEX-T2IS-3126-SM-32QPK GTEx Tissue Sample Gene Expression Profiles 1.0 1.6053 GTEX-U3ZN-0002-SM-3NMDF GTEx Tissue Sample Gene Expression Profiles 1.0 1.79198 7466_RPL36_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.567332 Orbital area, lateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26809 Lung squamous cell carcinoma_LUSC_TCGA-18-3412-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null firstly GeneRIF Biological Term Annotations 1.0 null GTEX-RVPU-0008-SM-3NM8B GTEx Tissue Sample Gene Expression Profiles 1.0 1.31748 CRCGN013_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.64198 Prostate adenocarcinoma_PRAD_TCGA-FC-A6HD-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ADCY6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37745 BTG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31316 GSE174735_1_v_0_il22_mouse RummaGEO Gene Perturbation Signatures 1.0 null superficial stratum of DTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07304 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NFIC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleus sagulum, superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.11457 HSPA9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10028 Lung adenocarcinoma_LUAD_TCGA-55-8090-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EJM Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.07024 GSE158834_12_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-3653 TargetScan Predicted Conserved microRNA Targets 1.0 0.32519 hsa-miR-544 TargetScan Predicted Conserved microRNA Targets 1.0 0.045136 Breast disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.517 CRCGN015_MCF10A.WT.HP_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.33293 NANOG-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null tumorigenicity GeneRIF Biological Term Annotations 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-A7LX-01A-12R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K70935154 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00222 TFE3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.546 hsa-miR-612 TargetScan Predicted Conserved microRNA Targets 1.0 0.212286 TGFBR1_knockdown_102_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.06116 GTEX-O5YW-1826-SM-2YUN2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.966095 Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE173232_4_v_3_sf3b1_human RummaGEO Gene Perturbation Signatures 1.0 null ANKRD44 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00548049 GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.10734 GTEX-RNOR-2426-SM-48FDY GTEx Tissue Sample Gene Expression Profiles 1.0 1.13883 RH30 CCLE Cell Line Gene CNV Profiles -1.0 -1.36935 H3K27ac_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 2490_EEF2_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.559994 GTEX-X8HC-0006-SM-46MV6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1722 Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GW-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null plasma membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042692 496100470_HIP_possible Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.02607 NANOG-18692474-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null ADIPOR2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00616807 PMC5013636-ncomms12601-s5.xlsx-SP1-Groups_SP1 Rummagene Transcription Factor Associations 2026 1.0 null response to stimulus GO Biological Process Annotations 2015 1.0 null central nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051 SNU-668 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.0827 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_NANOG_18347094 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02852 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.843011 Primary somatosensory area, trunk, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53831 SW 1463 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.964804 BRD-K25933460 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40445 head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05162 K562_Lenalidomide_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0186746 BRD-K41102088 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23531 EFL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75272 GTEX-SIU7-0001-SM-3NMAW GTEx Tissue Sample Gene Expression Profiles 1.0 2.29299 Adrenocortical carcinoma_ACC_TCGA-OR-A5LH-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100323_FWM_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.24486 Brain Lower Grade Glioma_LGG_TCGA-FG-A60K-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null zfx_17448993_embryonic_stem_cell_lof_mouse_gpl1261_gds2718 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.133193 H4K8ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null skeletal system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K56783915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05463 GSE130956_0_v_3_icaritin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-POYW-0008-SM-48TE4 GTEx Tissue Sample Gene Expression Profiles 1.0 2.02403 BRD-K38424085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26918 ND-39-PO34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.398327 ZBTB33_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A8BZ-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE229973_4_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K16251850 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10505 GSE87404,GSE87812_1_v_3_hoxa9_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE197564,GSE198512_0_v_1_mettl3_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K42899345 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36733 CRCGN008_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.258 GSE115364_0_v_1_idh3a_human RummaGEO Gene Perturbation Signatures 1.0 null GSE102467_3_v_0_pazopanib_human RummaGEO Drug Perturbation Signatures -1.0 null 496100326_TCx_no dementia_TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.13342 BRD-K61021741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08195 hsa-miR-3074-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.006367 GSE242290_3_v_0_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEC59 CCLE Cell Line Gene Expression Profiles -1.0 -1.4995 10623_ZNF774_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.596604 head of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02883 GSE216043_10_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051709 TIMM23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59349 NANOG-18358816-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null PAX2 JASPAR Predicted Transcription Factor Targets 1.0 null cell COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GSE146982_7_v_1_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null macromolecular complex disassembly GO Biological Process Annotations 2015 1.0 null CRCGN008_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.96775 intracellular COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.31191 corpus callosum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11558 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.32633 GTEX-NFK9-2026-SM-3LK5K GTEx Tissue Sample Gene Expression Profiles -1.0 -0.943102 CHD2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NL3H-0008-SM-4E3HU GTEx Tissue Sample Gene Expression Profiles 1.0 1.76377 HELA Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.25475 intermediate mantle of isBM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39656 Allan-Herndon-Dudley syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.693 hsa-miR-4477a TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 KDM5A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00371304 H2AK5ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE195503_3_v_2_progesterone_human RummaGEO Drug Perturbation Signatures -1.0 null YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4299 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 Primary somatosensory area, barrel field, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24877 OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.69382 POLR2A_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE60837_6_v_4_bcl9_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RTLS-0006-SM-2TF58 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.61772 hsa-miR-194 TargetScan Predicted Conserved microRNA Targets 1.0 0.008128 hsa-miR-320d TargetScan Predicted Conserved microRNA Targets 1.0 0.047969 periventricular stratum of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25473 H3K27ac_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-SP1_SP1 Rummagene Transcription Factor Associations 2026 1.0 null FOXC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 70.3486 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AV-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null K562_Filgotinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0176441 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.942266 Childhood Glioblastoma DisGeNET Gene-Disease Associations 1.0 null 6276_PHB_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.545523 EF-74-KW12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.631513 Anterior hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17958 primary auditory cortex (core)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.00641 CEBPB_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1 MotifMap Predicted Transcription Factor Targets 1.0 null WHSC1 ENCODE Transcription Factor Targets 1.0 null MAPK1 KEA Substrates of Kinases 1.0 null GTEX-NPJ8-1426-SM-3MJHR GTEx Tissue Sample Gene Expression Profiles 1.0 1.11438 BRD-K68060538 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13155 496100547_HIP_no dementia_no TBI_82_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.21385 GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01846 ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.17187 H3K4me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAF LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00646877 CDK10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0286 interstitial nucleus of Cajal, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.907562 Secondary motor area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.7764 VNN3P LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00481321 BRD-K02395808 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26787 POLR2A_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.723 NCIH889 CCLE Cell Line Gene CNV Profiles -1.0 -1.67127 BRD-K39752756 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49636 IGSF9B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12691 GABPA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K00950228 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32294 9686_UTP3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.1309 H3K27ac_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HA-E2F1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K85901675 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0264 GSE211128_9_v_0_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4N-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-7269-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K13074426 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30921 BRD-K13267677 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63527 hsa-miR-320a TargetScan Predicted Conserved microRNA Targets 1.0 0.047969 CRCGN009_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.07846 BRD-K38571893 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00463 TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPK5-0003-SM-3NMDI GTEx Tissue Sample Gene Expression Profiles 1.0 1.50587 BRD-K48188521 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11296 SOX9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.7237 GTEX-NPJ8-1626-SM-2HMIY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15196 MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 18400362-Figure2b GeneSigDB Published Gene Signatures 1.0 null 2545_EIF3B_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.73529 primary motor-sensory cortex (samples)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.877413 hsa-miR-3189-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Perturb_11321_KO_Dicer_SRP041679 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 U87MG_CENTRAL_NERVOUS_SYSTEM CCLE Cell Line Proteomics 1.0 2.13682 BA-56-QV45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.228272 chondrosarcoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CRCGN010_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.90529 GTEX-WFG8-0001-SM-4LVN8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32213 internal cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26809 MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WY7C-2726-SM-3NB3P GTEx Tissue Sample Gene Expression Profiles 1.0 0.980744 RAPGEF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48449 YY1 JASPAR Predicted Transcription Factor Targets 1.0 null Arx JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.7076 CRCGN016_MCF10A.TP53.M_24H:I11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.3734 GSE185944_0_v_3_pth1r_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.18508 Fibrosis CTD Gene-Disease Associations 1.0 1.30147 BRD-K82249895 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35801 AD-16-HL96_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.327121 dorsofrontal pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.29828 NELFE_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PLC/PRF/5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.944581 NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.62967 YY2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9527 GSU DepMap CRISPR Gene Dependency 1.0 2.53523 HPAC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.842235 GSE144231_3_v_1_cxcr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null r10 part of external cuneate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.6859 POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PBX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE153189_2_v_0_interferon gamma_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.438 MERO95 DepMap CRISPR Gene Dependency 1.0 2.46688 hsa-miR-4477b TargetScan Predicted Conserved microRNA Targets 1.0 0.056784 EB-09-OC36_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237035 BRD-K76329122 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0331 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AL-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null neck TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.581618 MXI1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r10 part of nucleus gracilis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02181 CRCGN015_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9095 GSE210383_0_v_1_trim71_mouse RummaGEO Gene Perturbation Signatures -1.0 null MDAMB435S CCLE Cell Line Gene Expression Profiles 1.0 1.94164 GTEX-WFJO-0002-SM-3P61X GTEx Tissue Sample Gene Expression Profiles 1.0 1.40387 GTEX-TSE9-0011-R4A-SM-3DB7H GTEx Tissue Sample Gene Expression Profiles 1.0 0.864709 CRCGN009_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.75205 hippocampus (hippocampal formation)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.72903 orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.37034 HOS GDSC Cell Line Gene Expression Profiles -1.0 -1.59396 GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.942869 CRCGN017_MCF10A.WT.HP_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.87355 GSE183271_1_v_0_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-4680-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.004732 H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.961274 H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null 9592_UNC45A_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.5513 G121 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08553 intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 SuperiorCervicalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.03317 DMS454 CCLE Cell Line Gene Expression Profiles -1.0 -1.59881 GSE165334_3_v_0_dabrafenib_human RummaGEO Drug Perturbation Signatures -1.0 null BC-52-WF67_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.37415 single-organism cellular process GO Biological Process Annotations 2015 1.0 null paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.23921 Lung adenocarcinoma_LUAD_TCGA-49-4506-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PBK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00518175 BRD-K28465224 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18515 PMC7782698-41467_2020_20367_MOESM9_ESM.xlsx-Student_s_t-test_BP1_ILK_GFP-Gene_names_DLX4 Rummagene Transcription Factor Associations 2026 1.0 null H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 2446_E4F1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.573403 JA-85-SW39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.347137 H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QLQW-0226-SM-447BJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.06982 Obesity_Muscle - Striated (Skeletal) (MMHCC)_GSE474 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.50662 FMR1_KD_GDS4759_333_mouse_E16 primary cortical neuron cultures GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null urinary bladder HPA Tissue Protein Expression Profiles 1.0 1.17767 GSE202434,GSE202438_3_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null SUZ12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11587 HCC827 DepMap CRISPR Gene Dependency 1.0 4.57855 TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.60757 SKN Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.71497 MAFF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.223 Prostate cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.215 NCIH524 CCLE Cell Line Gene Expression Profiles 1.0 1.37452 GTEX-S32W-0926-SM-4AD5X GTEx Tissue Sample Gene Expression Profiles 1.0 1.04238 K562_TMP195_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0166459 Lung adenocarcinoma_LUAD_TCGA-69-7760-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cSARS Bat SRBD_0Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.864703 CRCGN016_MCF10A.WT.HP_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.50135 H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4647 TargetScan Predicted Conserved microRNA Targets 1.0 0.078844 GTEX-P4QS-1326-SM-3NMCD GTEx Tissue Sample Gene Expression Profiles 1.0 1.16297 BRD-K27621887 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.60633 PMC10773028-40364_2023_552_MOESM1_ESM.xlsx-Variants_sheet-TFT_TBXT Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WEY5-0001-SM-3P61Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.67109 QA-50-YO37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.599236 hsa-miR-197 TargetScan Predicted Conserved microRNA Targets 1.0 0.062888 BRD-A03764094 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18122 EA-18-FP00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.442416 BZW2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19138 CRCGN015_HEPG2_48H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.80583 ZNF528 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.5097 POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null T84 GDSC Cell Line Gene Expression Profiles 1.0 1.70121 ERG-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null PMC6853299-pbio.3000476.s011.xlsx-Fig_4A-HVC_612_gene_expression_ratio_in_ZF_and_OF_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null YY1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.6222 MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adult Diffuse Large B-Cell Lymphoma DisGeNET Gene-Disease Associations 1.0 null GSE109285_3_v_2_glucagon_mouse RummaGEO Drug Perturbation Signatures -1.0 null SRY JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.5714 SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01183 MAPK3 KEA Substrates of Kinases 1.0 null Stomach cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.023 Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DDX3Y CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69615 periventricular stratum of DTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06853 A204 BioGPS Cell Line Gene Expression Profiles -1.0 -1.8084 GA-28-SS67_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.435633 lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.870576 Embryonic carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.589 amygdaloid complex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03026 GTEX-T6MN-2726-SM-4DM77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17709 CRCGN015_HEPG2_48H:I06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3788 2551_EIF3G_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.640233 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Anophthalmia And Pulmonary Hypoplasia DisGeNET Gene-Disease Associations 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.93404 CRCGN012_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.35521 MYBL2 ENCODE Transcription Factor Targets 1.0 null Skeletal muscle cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Eukaryotic translation initiation factor 2B complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.872 CRCGN017_MCF10A.WT.HP_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4574 VIPAS39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17854 ZBTB7A ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6407-01A-13R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Transcription preinitiation complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.288 XC-81-LR46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.43004 Adult Burkitt Lymphoma DisGeNET Gene-Disease Associations 1.0 null GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12681 GTEX-QXCU-0008-SM-48FCH GTEx Tissue Sample Gene Expression Profiles 1.0 1.57977 CRCGN010_HEPG2_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.21102 A172 CCLE Cell Line Gene CNV Profiles -1.0 -1.9289 CRCGN017_MCF10A.WT.HP_24H:E10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.9988 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null COLO 794 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.887209 GTF2F1 ENCODE Transcription Factor Targets 1.0 null POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BACH1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12917 MGA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5676 fertilizedegg BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.47383 hsa-miR-4652-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.015875 estradiol_mus musculus_gpl4134_gse23072 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35929 FE-10-KQ78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.592661 basal nucleus of Meynert Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.955216 GSE216043_7_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Geniculate group, ventral thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.48082 REST ENCODE Transcription Factor Targets 1.0 null Laryngeal squamous cell carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.06 PDCL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24768 GSE213228_4_v_0_irak2_human RummaGEO Gene Perturbation Signatures -1.0 null 16542501-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null GTF2B ENCODE Transcription Factor Targets 1.0 null TBXT JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.6088 posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.57932 H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null MEIS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.142 SIX5_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ1-0003-SM-3NMAE GTEx Tissue Sample Gene Expression Profiles 1.0 2.17151 GTEX-R55F-1526-SM-2TF4X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.991824 overexpression GeneRIF Biological Term Annotations 1.0 null RFX5 ENCODE Transcription Factor Targets 1.0 null BRD-K41709602 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16362 CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH660 Achilles Cell Line Gene Essentiality Profiles 1.0 1.40011 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ileocecum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.276 hsa-miR-140-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.454769 urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 MC-40-IP75_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.319484 mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.947362 enlarged spleen IMPC Knockout Mouse Phenotypes 1.0 null BRD-K03829970_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null t93 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.015 GTEX-NPJ7-0011-R11A-SM-2I3E8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34534 aromatic compound biosynthetic process GO Biological Process Annotations 2015 1.0 null HCC1428 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.36349 regulation of cell population proliferation GO Biological Process Annotations 2023 1.0 null globose nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.927902 superficial stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12712 MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 3.4277 Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H4-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELK4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SCC-4 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.24863 r6 part of spinal trigeminal nucleus, pars oralis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03504 Medial preoptic nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12139 BRD-A89471191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38631 MAX_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Autism DisGeNET Gene-Disease Associations 1.0 null H3K27ac_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE140322_0_v_2_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null Integument TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 7525_RPS3_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.77458 PKM LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00635276 GSE158834_10_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null describe GeneRIF Biological Term Annotations 1.0 null TWNK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22714 GTEX-OOBK-0625-SM-3LK5P GTEx Tissue Sample Gene Expression Profiles 1.0 0.923426 BRD-K92356505 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86271 Inflammation CTD Gene-Disease Associations 1.0 1.63586 BRD-K91548063 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07586 BRD-K19724398_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_K562_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFG7-0001-SM-3P61S GTEx Tissue Sample Gene Expression Profiles 1.0 2.43729 H3K9ac_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null AFD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0109123 BRD-K77535986 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10496 POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-221 TargetScan Predicted Conserved microRNA Targets 1.0 0.136254 transcription, dna-templated GO Biological Process Annotations 2015 1.0 null hsa-miR-182 TargetScan Predicted Conserved microRNA Targets 1.0 0.02452 K562_ABT-737_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0180931 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A263-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K10925833 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53605 BRD-K19378563 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65435 blood vessel GTEx Tissue Gene Expression Profiles -1.0 -0.964805 Vdr JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.5076 orbital frontal cortex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.12321 BRD-K56188108 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40445 SC-17-WW78_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.243563 GSE169205_3_v_5_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XLM4-0011-R9A-SM-4AT45 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.85621 Melanoma DisGeNET Gene-Disease Associations 1.0 null GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.989 BRD-K99447506 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12516 GSE199606_1_v_4_ricin_mouse RummaGEO Drug Perturbation Signatures 1.0 null cellular macromolecule biosynthetic process GO Biological Process Annotations 2015 1.0 null layer III of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.40684 GSE231891_5_v_4_cdk8_human RummaGEO Gene Perturbation Signatures 1.0 null mantle zone of PO1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33412 intracellular part GO Cellular Component Annotations 2015 1.0 null CREB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNOS-1526-SM-32PLW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.986252 BRD-K94014790 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.90829 CMK115 CCLE Cell Line Gene Expression Profiles 1.0 1.54739 KPL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.47424 g1 Phosphosite Textmining Biological Term Annotations 1.0 null LNCAP-CLONE-FGC COSMIC Cell Line Gene Mutation Profiles 1.0 null HCC2998 COSMIC Cell Line Gene Mutation Profiles 1.0 null precommissural nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.56112 BRD-K56661847 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69024 CRCGN016_MCF10A.TP53.M_24H:P20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.22562 TAF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77623 testis_7d HPA Tissue Sample Gene Expression Profiles -1.0 -1.01746 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.014 GTEX-PVOW-0006-SM-3NMB8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51241 GTEX-XMK1-1326-SM-4B65Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.39754 Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HJ-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.31027 ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GPN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13627 496100316_TCx_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.05092 A-Vietnam-1203_CIP048_RG4-2004(H5N1)HAAvirmut_2day-MOI-10^4_None_GSE37572 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.08595 GRHL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14248 inner CP in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02868 TAF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND ENCODE Transcription Factor Targets 1.0 null H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Leukemia DisGeNET Gene-Disease Associations 1.0 null EW7 DepMap CRISPR Gene Dependency 1.0 5.54183 JHH-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.25736 105_ACTG1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.626347 Median preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05182 KAT2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null overexpressing GeneRIF Biological Term Annotations 1.0 null OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.68556 BRD-K28264750 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12466 Perturb_2365_KD_MUC1_SRP173457 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.55343 CRCGN016_MCF10A.TP53.M_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.01759 T-47D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.842235 GTEX-XV7Q-2126-SM-4BRVX GTEx Tissue Sample Gene Expression Profiles 1.0 1.22604 U343 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.30957 NCI-H23 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.95399 7507_RPS18_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.905408 Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5Q6-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Secondary motor area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26136 253J CCLE Cell Line Gene Expression Profiles 1.0 1.38941 BRD-K29264158 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11171 Malignant Transformation DisGeNET Gene-Phenotype Associations 1.0 null H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WZTO-0826-SM-3NM8Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07941 gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 BRD-K94845132 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12454 BC-40-TU13_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.633726 SNU308 CCLE Cell Line Gene CNV Profiles 1.0 1.38398 intermediate stratum of TPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.03682 ribosomal subunit GO Cellular Component Annotations 2015 1.0 null BRD-K16231990 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3137 PTMA Pathway Commons Protein-Protein Interactions 1.0 null GSE123002_0_v_1_srsf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CEBPB ENCODE Transcription Factor Targets 1.0 null GTF2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Median eminence TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.812 BRD-K51322795 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.92901 posterior intralaminar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09883 metabolism GeneRIF Biological Term Annotations 1.0 null bed nucleus of stria terminalis, lateral amygdaloid division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16608 trunk TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.306805 PMC8481886-Table_1.xlsx-A_subsets-iMSC_fetal_MSC_UC_MSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null DorsalRootGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.22797 GTEX-T6MO-0003-SM-3NMAG GTEx Tissue Sample Gene Expression Profiles 1.0 1.81592 SPI1-23547873-NB4-HUMAN ChEA Transcription Factor Targets 2022 1.0 null pituitary GTEx Tissue Gene Expression Profiles 1.0 2.18646 GTEX-P4PQ-0626-SM-3NMCU GTEx Tissue Sample Gene Expression Profiles 1.0 0.958609 GSE180525,GSE180528_2_v_0_tbx3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE158834_7_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_12141_KO_Lgals9_ERP122370 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.3213 H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.559 urinary system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05296 BRD-K38040305 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15732 SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.972246 Liver hepatocellular carcinoma_LIHC_TCGA-ES-A2HT-01A-12R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042754 H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MDAMB231 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.844277 Field CA3, stratum lacunosum-moleculare Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00639 POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT549 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.832135 GTEX-S4Z8-0008-SM-33HAZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.04503 intermediate stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33079 cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.64913 H3K79me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050413 ZFP281-18358816-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null cellular response to stress GO Biological Process Annotations 2015 1.0 null 15257931-SuppTableA GeneSigDB Published Gene Signatures 1.0 null Head and neck carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.02 Lung adenocarcinoma_LUAD_TCGA-73-4670-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K86953192 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02389 FOXM1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ROS50 DepMap CRISPR Gene Dependency 1.0 3.97628 lateral part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17184 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Large ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.132 BRD-K60948317 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08555 PANC0327 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.23414 cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.32576 EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Breast Carcinoma DisGeNET Gene-Disease Associations 1.0 null GSE210101,GSE210114_0_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OIZG-1326-SM-2HMIQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.863189 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null 5729_NOC2L_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.945016 primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.837471 H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 BRD-K40814141 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0916 stomach BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.853499 periventricular stratum of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.80939 GTEX-RN64-1826-SM-48FDV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0659 GSE206984_1_v_0_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN017_MCF10A.TP53.M_24H:N10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.21507 NFIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.6436 BRD-K95485901 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35614 GTEX-X4EO-0006-SM-3P5ZF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81545 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.5313 CA-68-KG29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.314623 WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null estradiol_homo sapiens_gpl570_gds3283 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE163240_3_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null cellular_component COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FAHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01091 BRD-K38737333 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11465 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01105 KAT2A ENCODE Transcription Factor Targets 1.0 null HC-74-HM63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.328731 Thap11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.0985 GSE232558_0_v_1_fbxl12_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE70499_5_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.66966 Alx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.7094 PD-05-HV36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.204213 PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4 Rummagene Transcription Factor Associations 2026 1.0 null possible GeneRIF Biological Term Annotations 1.0 null BRD-K02548315 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14702 kidney TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053917 CREB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null High grade glioma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.163 intracellular part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null WT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10421 GSE158834_7_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null HCC202 CCLE Cell Line Gene CNV Profiles -1.0 -2.3514 TOX_01_331 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59946 BRD-K00667983 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06485 hsa-miR-1273d TargetScan Predicted Conserved microRNA Targets 1.0 0.069137 DMS 273 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.05602 mantle zone of PO2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36972 BRD-K66145389 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15547 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.974644 PMC9035581-HEP4-6-1157-s002.docx-3-Supplementary_Table_S5_Gene_expression_signature_of_endogenous_FOXS1_silencing_in_SNU-449_cells_FOXS1 Rummagene Transcription Factor Associations 2026 1.0 null STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Exercise-Induced Hyperinsulinism DisGeNET Gene-Disease Associations 1.0 null regulation of rna metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-RVPU-0011-R3A-SM-2XCAE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23415 salivarygland BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.00446 cerebellar cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.960246 u937 HPA Cell Line Gene Expression Profiles 1.0 0.996874 TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193258,GSE193259_5_v_13_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-5302-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null hsa-miR-4755-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 BC-00-YH62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.227525 GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYO1E Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53136 POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1 ENCODE Transcription Factor Targets 1.0 null GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78541 B-lymphoblast TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.22 IMR-90 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.867 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5887-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE93309_1_v_4_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ELK1 ENCODE Transcription Factor Targets 1.0 null EP300_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Peripheral nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.106 ISOC1 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-655 TargetScan Predicted Conserved microRNA Targets 1.0 0.020071 GSE211226_1_v_0_sirpa_mouse RummaGEO Gene Perturbation Signatures -1.0 null IZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.888227 dorsal spiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.87961 H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K02106348 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06008 GSE225218_8_v_3_abcb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE158834_10_v_8_palm_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null T47D Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.771577 Perturb_2496_KD_NXF1_SRP226431 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.29972 ventrolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00844 GTEX-R3RS-0008-SM-48FF1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04244 GSE93124_0_v_1_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-VJYA-0001-SM-3NMDJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.57281 BRD-K17185909 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.19883 JD-44-KF86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.370916 BRD-K11571815 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32041 Sarcoma_SARC_TCGA-QQ-A5V9-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Choroid plexus epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.041 CRCGN014_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.11995 7450_RPL23_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.807205 GTEX-OOBJ-0926-SM-48TDO GTEx Tissue Sample Gene Expression Profiles 1.0 0.922948 lines GeneRIF Biological Term Annotations 1.0 null principal sensory nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00104 GTEX-OOBK-2126-SM-3LK5T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00293 FOXM1 ENCODE Transcription Factor Targets 1.0 null K562_SB431542_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.022979 Lymphatic system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.391 TP53 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.2442 MMP26 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00545878 BRD-K11667893 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11607 MYC_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.67486 Alx4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.828 hsa-miR-656 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S12_LF_C1_8h-Unnamed_5_LTF Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-3121-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.09606 thyroid gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.661523 H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.326 GSE217452_3_v_0_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-W5WG-0002-SM-3NMDN GTEx Tissue Sample Gene Expression Profiles 1.0 3.37813 WRNIP1 ENCODE Transcription Factor Targets 1.0 null PIGW CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33478 GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE165647_2_v_3_cry2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WZTO-0011-R3B-SM-3NMC6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.83796 HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 20060365-SuppTable4 GeneSigDB Published Gene Signatures 1.0 null TAF1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JC-0001-SM-3NMAK GTEx Tissue Sample Gene Expression Profiles 1.0 1.21768 Perturb_4905_KO_NSUN6_SRP233222 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.2298 HCC1143 CCLE Cell Line Gene CNV Profiles 1.0 2.17585 hippocampus (hippocampal formation)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.901662 Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.159 H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K43680691 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23286 A549_Rigosertib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0116249 Prostate disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.213 thyroid_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.21289 MAPK1 Pathway Commons Protein-Protein Interactions 1.0 null ISTMES2 DepMap CRISPR Gene Dependency 1.0 2.58391 GTEX-SJXC-0008-SM-4DM7G GTEx Tissue Sample Gene Expression Profiles 1.0 0.912582 Bronchus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.21 cell-division Phosphosite Textmining Biological Term Annotations 1.0 null translation factor activity, nucleic acid binding GO Molecular Function Annotations 2015 1.0 null Lung cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.437 BT549 CCLE Cell Line Gene CNV Profiles 1.0 1.47049 IRF1 ENCODE Transcription Factor Targets 1.0 null GTEX-W5X1-0001-SM-3P61V GTEx Tissue Sample Gene Expression Profiles 1.0 1.68783 BRD-K47620421 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33556 osteoclasts BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.00025 H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:H08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4325 POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25S-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PALM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17636 496100463_FWM_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.18069 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SK-UT-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.91588 Carcinoma Of Bladder DisGeNET Gene-Disease Associations 1.0 null central part of MPO Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34704 mantle zone of r10BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06034 BRD-K69348766 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38086 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 H3K4me3_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-D-Enh_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null increased circulating alkaline phosphatase level IMPC Knockout Mouse Phenotypes 1.0 null BRD-K40804250 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17007 H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC12289921-41467_2025_62099_MOESM5_ESM.xlsx-MI-2-80-Gene_Symbol_MITF Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WFG7-1126-SM-4LMK3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.902107 Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A620-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null urinary tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052862 TE4 DepMap CRISPR Gene Dependency 1.0 2.2065 ZNF384_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PK-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36745 hsa-miR-3671 TargetScan Predicted Conserved microRNA Targets 1.0 0.02452 ires-dependent translational initiation GO Biological Process Annotations 2015 1.0 null GTEX-PVOW-0011-R1A-SM-32PL6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03403 GTEX-NPJ8-2626-SM-2D7W2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22482 H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEx Heart 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures -1.0 -8.18671 ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X585-0011-R2B-SM-46MVF GTEx Tissue Sample Gene Expression Profiles 1.0 0.951803 GTEX-U412-0326-SM-3DB9L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54962 Perturb_14083_KD_HSF1_SRP258163 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.01661 PBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 52.7742 imatinib_homo sapiens_gpl96_gds3046 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in septal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.5026 PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN Rummagene Transcription Factor Associations 2026 1.0 null JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00821 BRD-K34110797 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59386 MTA3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and neck squamous cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.033 H2AFZ ENCODE Transcription Factor Targets 1.0 null GSE202434,GSE202438_9_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null CP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.904611 CRCGN015_MCF10A.TP53.M_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.8382 BRD-K25199508 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58758 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN014_HEPG2_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.90766 ZNF281 ChEA Transcription Factor Targets 1.0 null BRD-K87593103 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15057 CRCGN017_MCF10A.WT.HP_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.19155 BRD-K12460934 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35865 BRD-K07152092 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34687 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of m2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36972 GABPA_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null heterocycle biosynthetic process GO Biological Process Annotations 2015 1.0 null GTEX-X4XX-0005-SM-3NMCS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.982925 FADU CCLE Cell Line Gene CNV Profiles 1.0 3.2803 Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F0-01A-12R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R0-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-TMZS-0326-SM-3DB9P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3083 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JG-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral part of m2A Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.01359 Paracentral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05837 CB-16-SY72_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.349569 PMC11756367-peerj-13-18820-s001.xls-SP1-Target_SP1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-P44H-0011-R11A-SM-2XCER GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36901 CEBPB-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_UNC1999_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0189603 mantle zone of r10Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06939 GTEX-REY6-0726-SM-2TF4M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45696 transport GeneRIF Biological Term Annotations 1.0 null AD-86-OB87_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.344711 SREBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.982 H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE101767_1_v_0_wdr11_mouse RummaGEO Gene Perturbation Signatures 1.0 null Liver carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.031 Lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.413 BRD-K04378630 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1314 BRD-K70148257 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24895 hepg2 HPA Cell Line Gene Expression Profiles -1.0 -1.31079 lymphnode_4a HPA Tissue Sample Gene Expression Profiles 1.0 0.992639 H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1187 CCLE Cell Line Gene CNV Profiles 1.0 1.48583 Primary visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.00258 PMC11385078-jciinsight-9-172336-s272.xlsx-1DEseq2_Report_AA_BL_vs_EA_BL-Unnamed_1_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K36537572 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23281 heart ProteomicsDB Cell Type and Tissue Protein Expression Profiles -1.0 -0.906434 GTEX-XXEK-0626-SM-4BRWE GTEx Tissue Sample Gene Expression Profiles 1.0 1.02117 central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null macromolecule biosynthetic process GO Biological Process Annotations 2015 1.0 null hsa-miR-4426 TargetScan Predicted Conserved microRNA Targets 1.0 0.082179 BRD-K25322420 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63615 ZNF76 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.7923 CRCGN009_HEPG2_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.35385 BRD-K24422491 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05375 GSE237053_1_v_0_comt_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HCC4006 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.01879 hsa-miR-4255 TargetScan Predicted Conserved microRNA Targets 1.0 0.02226 regulation of metabolic process GO Biological Process Annotations 2015 1.0 null FOS ENCODE Transcription Factor Targets 1.0 null GTEX-XYKS-0002-SM-4BRWN GTEx Tissue Sample Gene Expression Profiles 1.0 1.53186 ADAD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00697936 hsa-miR-1203 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GTEX-X8HC-1626-SM-46MWE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.91314 Primary visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12139 PPARD ChEA Transcription Factor Targets 1.0 null GTEX-S33H-0626-SM-2XCBJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.926398 NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.914379 Perturb_6170_KD_PROX1_SRP073100 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.01882 H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-338-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.136254 parastrial preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13801 Primary visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.4029 CEBPB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE108614,GSE108615_0_v_2_setd1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null FOXD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 95.8189 H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QEG5-1426-SM-447AS GTEx Tissue Sample Gene Expression Profiles 1.0 1.06816 lymphnode_4b HPA Tissue Sample Gene Expression Profiles 1.0 1.01129 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AY-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-67-3772-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Twitch muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.925 hsa-miR-4742-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.015875 GSE158834_10_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MAX_WT_TESTES_MAX Rummagene Transcription Factor Associations 2026 1.0 null H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN012_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.0006 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67887 hsa-miR-3187-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.199275 RUNX3 ENCODE Transcription Factor Targets 1.0 null GTEX-PLZ6-0226-SM-3P61I GTEx Tissue Sample Gene Expression Profiles 1.0 0.976657 Lung squamous cell carcinoma_LUSC_TCGA-43-7656-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE209938_0_v_1_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null rectum HPA Tissue Gene Expression Profiles 1.0 0.927558 hsa-miR-1264 TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3383-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.22426 CRCGN017_MCF10A.WT.HP_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.8586 lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.3309 inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.60792 POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WVLH-0006-SM-3MJF7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7332 GSE152699,GSE152723_0_v_1_vemurafenib_human RummaGEO Drug Perturbation Signatures -1.0 null UBXN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45007 BRD-K10221669 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67885 9909_XRCC6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.571279 ATF3 ENCODE Transcription Factor Targets 1.0 null SHANK3_KD_GDS4759_338_mouse_E16 primary cortical neuron cultures GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null OC-10-FB51_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.221002 UBR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13396 H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MYC_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOSL2::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.408 COLO205 DepMap CRISPR Gene Dependency 1.0 2.47713 translation reinitiation GO Biological Process Annotations 2025 1.0 null organelle organization GO Biological Process Annotations 2015 1.0 null H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4416014-pone.0125585.s010.xls-d_-BNC_network-Interactor_B_BNC1 Rummagene Transcription Factor Associations 2026 1.0 null GSE178714_3_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null REST_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE88819_1_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K88069191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23121 BD-04-NG34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.402556 hippocampus (hippocampal formation)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.835795 TUBB4B Pathway Commons Protein-Protein Interactions 1.0 null mitogen-activated-protein-kinase-1 Phosphosite Textmining Biological Term Annotations 1.0 null GTEX-XMD1-0011-R11A-SM-4AT5J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58073 CRCGN008_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5698 PMC8494348-pone.0257161.s002.xlsx-D20-OXT_ext_D20-OXT_NOT_ext-Gene_Name_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null CREB3L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.3603 ARID3A ENCODE Transcription Factor Targets 1.0 null Urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.035 metabolic process GO Biological Process Annotations 2015 1.0 null Eukaryotic translation initiation factor 2 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.057 PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-12_names_TP53 Rummagene Transcription Factor Associations 2026 1.0 null SNU-449 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.915963 5762_NPAT_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.596685 cisplatin_homo sapiens_gds3910 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-RUSQ-0826-SM-47JWW GTEx Tissue Sample Gene Expression Profiles 1.0 1.20531 GSE211983_0_v_3_nicotine_mouse RummaGEO Drug Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A74L-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE144919,GSE145177_1_v_0_dazl_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE113952,GSE113953_1_v_0_chtop_human RummaGEO Gene Perturbation Signatures -1.0 null Presubiculum, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08139 primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.838396 Immune system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.411 GSE169152_5_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null RS411 Achilles Cell Line Gene Essentiality Profiles 1.0 1.26304 GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.11716 Uterine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.017 DA-66-OE69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.62075 POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1229 TargetScan Predicted Conserved microRNA Targets 1.0 0.082179 MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE201309_5_v_3_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null Autonomic nervous system neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.072 Perturb_5429_KD_ATF3_SRP308440 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.59913 EW8 CCLE Cell Line Gene CNV Profiles -1.0 -1.49316 eoc GeneRIF Biological Term Annotations 1.0 null GSE142210_9_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_down_VENN-1175_elements_included_exclusively_in_HIF1_down_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10624900-41467_2023_42825_MOESM13_ESM.xlsx-Module_3-ZNF195_ZNF195 Rummagene Transcription Factor Associations 2026 1.0 null regulation of biosynthetic process GO Biological Process Annotations 2015 1.0 null RAB7A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00492833 GTEX-PW2O-0008-SM-48TEB GTEx Tissue Sample Gene Expression Profiles 1.0 0.993825 cell periphery COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.210203 Nuclear pore outer ring COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.813 ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.343 PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_EVT-Gene_Symbol_GCM1 Rummagene Transcription Factor Associations 2026 1.0 null PMC8733431__F7 PFOCR Pathway Figure Associations 2024 1.0 null Brain Lower Grade Glioma_LGG_TCGA-VM-A8CB-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20348 BRD-K52713598 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14733 GSE202434,GSE202438_4_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE183413_1_v_2_ash1l_mouse RummaGEO Gene Perturbation Signatures -1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4RT-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAPH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02303 GSE213588_9_v_5_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null NCIH1373 CCLE Cell Line Gene Expression Profiles 1.0 1.88468 18410693-TableS5 GeneSigDB Published Gene Signatures 1.0 null FOXO1-25302145-T-LYMPHOCYTE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN016_MCF10A.WT.HP_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3047 GSE158834_7_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K88357881 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04293 PMC6668037-NIHMS1530019-supplement-3.xlsx-AR_differential_binding-Gene_Name_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S32W-2326-SM-2XCAW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50656 cellular nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null YY1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE109913_1_v_2_bleomycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Cerebrovascular endothelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.679 GTEX-P4QT-0008-SM-48TDZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.20206 GSE202825_2_v_1_ano1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE145790_0_v_1_bruceantin_human RummaGEO Drug Perturbation Signatures 1.0 null NELFE ENCODE Transcription Factor Targets 1.0 null oligonucleotide GeneRIF Biological Term Annotations 1.0 null PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_proteinGroups-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null imatinib_homo sapiens_gpl96_gds3043 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE190384,GSE190386_2_v_8_fulvestrant_human RummaGEO Drug Perturbation Signatures -1.0 null polymorphic layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.962881 layer IIIu of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.31212 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.697 H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null primary auditory cortex (core)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.33214 Msx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.2178 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10U-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73G-01A-22R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE202434,GSE202438_2_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null PANC-02-03 COSMIC Cell Line Gene Mutation Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K96968070 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4914 CE-69-HJ13_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.384015 GATA2_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE147056_2_v_1_actl6b_mouse RummaGEO Gene Perturbation Signatures -1.0 null TAL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCIH520 DepMap CRISPR Gene Dependency 1.0 2.14057 SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IB-67-WH43_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.208163 Respiratory epithelium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.21 TRIM52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54168 1943_CTR9_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.632839 Brain capillary endothelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.507 FHIP2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39586 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN011_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3801 Cerebrovascular endothelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.561 TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striohypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31519 H3K27ac_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NF-21-HQ00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.376017 GC-04-UF36_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.641995 HCC12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null SIN3A_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-HP-A5MZ-01A-21R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-34c-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.006367 GSE140965_1_v_4_mybpc3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE178907_5_v_3_fkrp_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null DPEP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00680136 glycogen-synthase-kinase-3 Phosphosite Textmining Biological Term Annotations 1.0 null mantle zone of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.01359 Infralimbic area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32137 Perturb_9457_OE_Rnaseh1_SRP182028 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.53419 intermediate stratum of isLim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08776 system GeneRIF Biological Term Annotations 1.0 null BRD-K67531128 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11741 DA-10-VU83_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.207502 Pallidum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05394 Recurrent Tumor DisGeNET Gene-Phenotype Associations 1.0 null PMC10153265-media-3.xlsx-BENPORATH_SOX2_TARGETS_v2023_1-STANDARD_NAME_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2 Rummagene Transcription Factor Associations 2026 1.0 null MXI1 ENCODE Transcription Factor Targets 1.0 null anterior amygdaloid area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00867 head TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GTEX-U8T8-1226-SM-4E3IH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.944752 GTEX-OXRN-0005-SM-2I5EU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30252 PMC10773028-40364_2023_552_MOESM2_ESM.xlsx-Variants_sheet-TFT_TBXT Rummagene Transcription Factor Associations 2026 1.0 null SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.919309 GSE124375_13_v_0_chd2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-3163 TargetScan Predicted Conserved microRNA Targets 1.0 0.257113 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null periventricular stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25404 ZC3H11A ENCODE Transcription Factor Targets 1.0 null USP5 Pathway Commons Protein-Protein Interactions 1.0 null 7476_RPL6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.666263 BRD-K46561246 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43151 GATA3 ENCODE Transcription Factor Targets 1.0 null erk Phosphosite Textmining Biological Term Annotations 1.0 null IGR1 CCLE Cell Line Gene CNV Profiles -1.0 -1.7177 WM793 DepMap CRISPR Gene Dependency 1.0 3.17315 GSE158834_12_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null ELF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Infralimbic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.69022 CRCGN016_MCF10A.TP53.M_24H:A22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.61555 FB-91-BU05_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.253604 H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ARID3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K33891642 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06838 GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.82452 C3A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10773 hsa-miR-203 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GSE203329_0_v_1_mettl5_human RummaGEO Gene Perturbation Signatures 1.0 null H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17976 GTEX-QEL4-2126-SM-447AE GTEx Tissue Sample Gene Expression Profiles 1.0 1.03856 PBX3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null tonsil HPA Tissue Gene Expression Profiles 1.0 1.81044 OCUBM DepMap CRISPR Gene Dependency 1.0 3.96403 SK-GT-2 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.04525 NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-A5MP-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_UNC0379_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0172729 GSE214442_0_v_1_pak4_mouse RummaGEO Gene Perturbation Signatures 1.0 null apoptosis GeneRIF Biological Term Annotations 1.0 null GTEX-QVUS-0011-R3A-SM-3GAFD GTEx Tissue Sample Gene Expression Profiles 1.0 1.01617 hsa-miR-1207-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.32519 PDE3B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00519198 CREB3L4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.7903 UTP14A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06712 SARS-CoV MA15_Day7-PFU-10^5_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.74669 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2H1-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FF-28-ES17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.262134 GSE232223_1_v_0_letmd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null DU145 BioGPS Cell Line Gene Expression Profiles -1.0 -0.860016 17210682-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null OSC-19 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.50939 POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA2 ENCODE Transcription Factor Targets 1.0 null BRD-K23366960 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38358 ventrolateral part of m2A Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66974 Uterine Carcinosarcoma_UCS_TCGA-NF-A4X2-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WHSE-0011-R11A-SM-3P5YY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00063 GTEX-REY6-0005-SM-2TF54 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22897 OVCA 429 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.963561 BRD-K75073374 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11163 Type I spiral ganglion neuron_Brain_Mouse CellMarker Gene-Cell Type Associations 1.0 null hsa-miR-28-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.09606 layer IIIa of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04438 Prostate adenocarcinoma_PRAD_TCGA-G9-6363-01A-21R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K91796483 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.00026 Hypoglossal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59605 PPP2R5C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00457272 tRNA-intron endonuclease complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.715 CRCGN015_MCF10A_48H:H13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.37565 NCI-H838 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.31931 GTEX-Q2AG-0008-SM-48U2K GTEx Tissue Sample Gene Expression Profiles 1.0 1.21802 GTEX-SJXC-0005-SM-2XCE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.46612 FZD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33085 BRD-K47164766 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63562 VHL Hub Proteins Protein-Protein Interactions 1.0 null GSE146982_3_v_1_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PEO1 DepMap CRISPR Gene Dependency 1.0 4.60646 CRCGN016_MCF10A.TP53.M_24H:H19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.28891 Perturb_4341_OE_MYT1L_SRP271657 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 9.86105 A549_Avagacestat_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153243 7454_RPL27A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.743242 MEF2A JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-T6MN-0011-R1A-SM-32QOY GTEx Tissue Sample Gene Expression Profiles 1.0 1.16971 hsa-miR-3065-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.02452 L-363 GDSC Cell Line Gene Expression Profiles 1.0 1.61213 HD-29-LW24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.670166 TAL1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE131649_4_v_9_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K35296094 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48472 HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LOXIMVI CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 heterocycle metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-P4PP-0008-SM-48TDV GTEx Tissue Sample Gene Expression Profiles 1.0 1.43438 PANC0403 CCLE Cell Line Gene CNV Profiles 1.0 1.33099 presence GeneRIF Biological Term Annotations 1.0 null Immunosuppression DisGeNET Gene-Disease Associations 1.0 null GSE213588_9_v_1_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null FOS JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.6049 H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null serum GeneRIF Biological Term Annotations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-33-4589-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.8722 REST_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE202434,GSE202438_10_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null LCLC-97TM1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.866009 DAUDI COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-548m TargetScan Predicted Conserved microRNA Targets 1.0 0.03694 GSE206516,GSE206518_0_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K69718434 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02653 ventrolateral prefrontal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.9046 GTEX-SIU8-0526-SM-2XCDP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12242 hsa-miR-3677-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 Kidney Chromophobe_KICH_TCGA-KO-8411-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.854213 BRD-K58876832 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0136 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04628 mantle zone of m2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66974 BIRC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.2288 BRD-K40674409 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25897 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NPRL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1109 HC-74-HM63_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.483711 DLG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02188 hsa-miR-944 TargetScan Predicted Conserved microRNA Targets 1.0 0.02452 KDM5A-27292631-CHIP-SEQ-BREAST-HUMAN ChEA Transcription Factor Targets 2022 1.0 null 10803_NON-TARGETING_NON-TARGETING Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.529715 H3K79me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NAE1 Pathway Commons Protein-Protein Interactions 1.0 null MDAMB175VII Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.87175 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8043-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung non-small cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.198 GTEX-P4QR-0008-SM-48TE2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.1599 H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-DC-5337-01A-01R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 1893_CSE1L_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.509114 H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-324-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.17031 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K12376164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06968 ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null kinase GeneRIF Biological Term Annotations 1.0 null r6 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25672 BRD-K15997423 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78683 BRD-K56618252 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43772 Perturb_2355_KD_HOXA11_SRP072302 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.75219 GC-04-UF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.35697 Paraventricular hypothalamic nucleus, parvicellular division, anterior parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.31572 GTEX-R55E-2726-SM-48FCX GTEx Tissue Sample Gene Expression Profiles 1.0 1.18325 SW1573 CCLE Cell Line Gene CNV Profiles -1.0 -2.00406 KALS1 CCLE Cell Line Gene Expression Profiles 1.0 1.63947 DU 145 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04453 biological regulation GO Biological Process Annotations 2015 1.0 null CRCGN015_MCF10A_48H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -6.43945 NUTM2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09433 PMC5998130-41467_2018_4619_MOESM10_ESM.xlsx-OHT_ESR1-Unnamed_2_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null Huntington's Disease_Brain_GSE3621 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.61821 GTEX-XV7Q-0426-SM-4BRVN GTEx Tissue Sample Gene Expression Profiles 1.0 0.828592 H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Translation-associated RNA-binding, predicted InterPro Predicted Protein Domain Annotations 1.0 null H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DMS153 CCLE Cell Line Gene CNV Profiles 1.0 1.59771 bone TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nephron TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062079 BRD-K20236423 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04602 CRCGN015_MCF10A.TP53.M_24H:F24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4179 Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r10 part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.80939 HS 852.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.46939 SNUC1 CCLE Cell Line Gene CNV Profiles 1.0 1.43492 BRD-K41517267 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03698 BRD-K61533770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.334 malignancies Phosphosite Textmining Biological Term Annotations 1.0 null Cancer of thyroid_Thyroid_GSE5364 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.59873 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-NR2F2_NR2F2 Rummagene Transcription Factor Associations 2026 1.0 null liminal reticular formation of m2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42213 gliomas GeneRIF Biological Term Annotations 1.0 null layer 1 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36305 Respiratory system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.47 corneal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.384013 GTEX-X4XY-0011-R8A-SM-46MVC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.88569 MF-11-EW49_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.25005 Anterior cingulate area, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05837 H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K28276275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.19725 Acute Myeloid Leukemia_LAML_TCGA-AB-2955-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A5UE-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE142684_0_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null S0-EE-Y4UM_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.226987 GATA1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39X-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE195663_7_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null r2 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06939 HCC38 CCLE Cell Line Gene CNV Profiles 1.0 1.93493 7461_RPL34_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.600034 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K85532500 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3872 BRD-K65446780 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13359 epidermis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.06198 PMC9795333-mmc4.xlsx-HUES66_Ex_CTIP2_C3-X-linked_genes_BCL11B Rummagene Transcription Factor Associations 2026 1.0 null NCIH838 Achilles Cell Line Gene Essentiality Profiles 1.0 1.37504 SP4 ENCODE Transcription Factor Targets 1.0 null GTEX-XUW1-0726-SM-4BOP5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08119 anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.77969 HDAC2 ENCODE Transcription Factor Targets 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8435-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null subbrachial nucleus, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.81094 H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:P13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.03695 BRD-K29661539 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10269 BRD-K31521981 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.92131 NFIC JASPAR Predicted Transcription Factor Targets 1.0 null sequencespecific GeneRIF Biological Term Annotations 1.0 null pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.685016 FF-86-NH56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.378253 BRD-K26866198 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03356 GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77866 GTEX-T5JW-0003-SM-3NMAD GTEx Tissue Sample Gene Expression Profiles 1.0 1.60156 MZ in rostral midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02525 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K24494475 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29788 BRD-K85474153 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56513 LIMK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00702798 USP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26617 H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K25878187 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20394 Brain Lower Grade Glioma_LGG_TCGA-DB-A64R-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JAK2_activemutant_72_GSE21842 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.89384 GSE149760_3_v_1_elof1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE142210_2_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-30d TargetScan Predicted Conserved microRNA Targets 1.0 0.039622 GSE226316_0_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null BCL7C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00695008 immune system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.273664 AB-37-JM16_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.236329 MAFK_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_S3I-201_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0197853 FANCD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24635 plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.229176 H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.96417 Skin Cutaneous Melanoma_SKCM_TCGA-GF-A4EO-06A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.1511 intracellular organelle part GO Cellular Component Annotations 2015 1.0 null Proteinuria CTD Gene-Disease Associations 1.0 1.04239 20103679-ST3-C GeneSigDB Published Gene Signatures 1.0 null HUH1 DepMap CRISPR Gene Dependency 1.0 4.52131 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09818 18362358-Table10 GeneSigDB Published Gene Signatures 1.0 null GTEX-QV44-0926-SM-2S1RH GTEx Tissue Sample Gene Expression Profiles 1.0 1.10191 BRD-K73929798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16866 DENR Pathway Commons Protein-Protein Interactions 1.0 null posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01356 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SRF_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null instability GeneRIF Biological Term Annotations 1.0 null cytosolic part GO Cellular Component Annotations 2015 1.0 null GSE211128_4_v_0_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null GSE248770_0_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null ERLEC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63428 estradiol_homo sapiens_gpl570_gse23610 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.044867 response to stress GO Biological Process Annotations 2015 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2814-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GU-06A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K44684577 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50421 r9 part of nucleus gracilis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51436 GSE139992_1_v_0_mboat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null L-363 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.01879 hsa-miR-4759 TargetScan Predicted Conserved microRNA Targets 1.0 0.059817 EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.58765 BRD-K93339508 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59799 GSE167218_1_v_0_hoxd12_mouse RummaGEO Gene Perturbation Signatures 1.0 null N1-S1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.094 E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPT6-0001-SM-4B64G GTEx Tissue Sample Gene Expression Profiles 1.0 1.84227 Secondary Malignant Neoplasm Of Bone DisGeNET Gene-Disease Associations 1.0 null regulation of cellular metabolic process GO Biological Process Annotations 2015 1.0 null ASB6 Pathway Commons Protein-Protein Interactions 1.0 null macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null CRCGN015_MCF10A.TP53.M_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.72675 ventrolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.47573 SW48 GDSC Cell Line Gene Expression Profiles -1.0 -1.45535 hsa-miR-3127-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.013856 Hematopoietic system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.349 PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-D-Enh_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.11813 GSE169152_5_v_7_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null CSTF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00768 CRCGN015_MCF10A.TP53.M_24H:L15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.28025 NANOG-18692474-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null IGF1R_knockdown_52_GSE16684 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.45007 CRCGN010_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.21452 KAT2B ENCODE Transcription Factor Targets 1.0 null HCC1359 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.48768 BRD-K50474387 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44492 YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Field CA3, stratum lucidum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.48735 GTEX-RU72-0011-R11A-SM-2TF6J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.941686 SPI1_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.914379 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4696-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF770 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.0438 periventricular stratum of r7Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38173 BRD-A55408860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42253 BRD-K65399214 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04307 GSE205729,GSE205731_2_v_1_tazemetostat_human RummaGEO Drug Perturbation Signatures -1.0 null MEF2A_KD_GDS4759_340_mouse_E16 primary cortical neuron cultures GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null LCN12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4084 vertebrate muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054002 cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.07024 Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y8-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.5623 hsa-miR-4323 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 UACC-893 COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-522 TargetScan Predicted Conserved microRNA Targets 1.0 0.020071 GSE133087_5_v_0_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null NKX2-4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.3298 therapeutic Phosphosite Textmining Biological Term Annotations 1.0 null 7526_RPS4X_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.685064 fallopian tube HPA Tissue Protein Expression Profiles 1.0 1.17767 AGTRAP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00667348 GTEX-S32W-1926-SM-4AD63 GTEx Tissue Sample Gene Expression Profiles 1.0 1.46929 GTEX-TMMY-0426-SM-33HBB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22797 BRD-K87316858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22255 Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.006 BRD-K66299486 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09169 GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6022 18310505-TableS7 GeneSigDB Published Gene Signatures 1.0 null PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:N17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.46063 DUX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 63.3797 indicates GeneRIF Biological Term Annotations 1.0 null CRCGN013_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.30077 GSE147056_0_v_1_actl6b_mouse RummaGEO Gene Perturbation Signatures -1.0 null SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08553 rectum_8c HPA Tissue Sample Gene Expression Profiles 1.0 1.26979 GSE88819_7_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null HDAC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14119 ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.33995 p1 part of parabrachial pigmented nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29762 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 MPP-89 GDSC Cell Line Gene Expression Profiles -1.0 -2.60116 TRIM33_KD_GDS4071_449_human_HMEC-TR mammary epithelial cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-QXCU-0006-SM-2TC5K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1568 ACMSD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00624848 H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Baricitinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0176991 GTEX-T8EM-0526-SM-4DM64 GTEx Tissue Sample Gene Expression Profiles 1.0 0.985738 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Micronuclei, Chromosome-Defective CTD Gene-Disease Associations 1.0 1.30177 PPARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.3929 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K16862492 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.034 Lymphoma_burkitts(Daudi) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.41487 Uterine Cervical Neoplasms CTD Gene-Disease Associations 1.0 1.02262 EIF5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21474 BRD-K04116560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56608 2622_EMG1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.656414 Anterior hypothalamic nucleus, central part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1822 H3K27ac_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 PROP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 88.7714 BRD-K50114736 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6422 hsa-miR-1271 TargetScan Predicted Conserved microRNA Targets 1.0 0.029271 BRD-K04044480 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06252 BRD-K37262314 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36574 cellular_component GO Cellular Component Annotations 2015 1.0 null hsa-miR-652-3p MiRTarBase microRNA Targets 1.0 null GSE212760_0_v_1_fxr1_human RummaGEO Gene Perturbation Signatures 1.0 null nucleus sagulum, deep part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58768 SUMO1 Hub Proteins Protein-Protein Interactions 1.0 null GTEX-R3RS-1326-SM-48FE7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.892489 Perturb_6756_KO|KD_UPF3A/UPF3B|UPF1_SRP327782 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.98347 KMS27 CCLE Cell Line Gene Expression Profiles 1.0 1.8316 NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.65387 Laryngeal squamous cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.03 GTF3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25363 Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POU4F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 72.5203 D423MG DepMap CRISPR Gene Dependency 1.0 3.07194 Brain Lower Grade Glioma_LGG_TCGA-DU-A6S8-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K29560103 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36649 H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ATF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050648 H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WWYW-0526-SM-3NB2W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14869 parasolitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.937813 USP2_KO_GDS5079_25_mouse_kidney GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null HCA-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.85391 ATP8B2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00562338 regulation of primary metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-RN64-0326-SM-2TC5J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05641 TBC1D10A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37101 dorsal part of JcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04998 LOXIMVI CCLE Cell Line Gene Expression Profiles -1.0 -3.9989 BRD-K78659596_MLN2238_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null OXA1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27919 BRD-K38510068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42035 PAX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.3803 SCAMP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30176 hsa-miR-4446-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 CRCGN015_MCF10A.TP53.M_24H:F21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5613 Perturb_2682_KD_YAP1_SRP181909 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.78523 LUDLU1 CCLE Cell Line Gene CNV Profiles 1.0 1.38604 20460173-ImmPortComprehensiveListofImmune-RelatedGenes GeneSigDB Published Gene Signatures 1.0 null mantle zone of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05059 TFK1 DepMap CRISPR Gene Dependency 1.0 6.12738 GTEX-UJHI-1726-SM-3DB9B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06078 Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q4-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHRNA2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00488457 GTEX-RWSA-1126-SM-2XCAZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.873401 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_65_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN012_HEPG2_24H:P07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.09272 CRCGN017_MCF10A.WT.HP_24H:J20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.28895 Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0EZ-01A-21R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U8T8-0126-SM-3DB94 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13229 GTEX-RU72-0726-SM-46MUW GTEx Tissue Sample Gene Expression Profiles 1.0 1.15395 FGFR2_activemutant_59_GSE17916 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.15081 K562_Enzastaurin_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0241277 SLC16A7+ cell_Lung_Human CellMarker Gene-Cell Type Associations 1.0 null Basal tubulobulbar complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.948 Nucleus sagulum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0274 GTEX-XBED-2626-SM-4E3J5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84234 SIN3A_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-7138-01A-41R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null APOBEC3B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00621439 UBAC1 Pathway Commons Protein-Protein Interactions 1.0 null JHOM1 Achilles Cell Line Gene Essentiality Profiles 1.0 1.12831 MS751 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.88698 intermediate part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06034 GSE239844_8_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null PMC7415402-oncotarget-11-2995-s004.xlsx-EWS-FLI1_Type_1_vs_Type_3-Gene_Symbol_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null IPO9 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XGQ4-2426-SM-4AT55 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.9015 CRCGN016_MCF10A.TP53.M_24H:D18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.05429 MAFF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A6SH-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral part of MPO Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.42576 HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.58608 7451_RPL24_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.71948 COLO818 CCLE Cell Line Gene Expression Profiles -1.0 -2.14729 GSE136622_7_v_3_srpk3_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K51707293 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34866 BRD-K83697352 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11036 pathology Phosphosite Textmining Biological Term Annotations 1.0 null GTEX-RNOR-0005-SM-2TF4Z GTEx Tissue Sample Gene Expression Profiles -1.0 -2.19444 rpmi8226 HPA Cell Line Gene Expression Profiles 1.0 0.898249 PMC11655728-12672_2024_1562_MOESM2_ESM.xlsx-Sheet1-Hs_ESC_NANOG_targets_Boyer_NANOG Rummagene Transcription Factor Associations 2026 1.0 null r10 part of vagal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.45508 oculomotor nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.868161 GTEX-XBED-0003-SM-47JWP GTEx Tissue Sample Gene Expression Profiles 1.0 1.52483 targeting Phosphosite Textmining Biological Term Annotations 1.0 null 7516_RPS27A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.941586 H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null eye TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059623 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A449-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKMG1 DepMap CRISPR Gene Dependency 1.0 4.36285 Triple-Negative Breast Carcinoma DisGeNET Gene-Disease Associations 1.0 null H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X4EO-0526-SM-3P5Z3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32946 CRCGN011_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9002 7163_RBM19_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.523285 m1Lim part of the midbrain reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01927 GTEX-S7PM-0011-R6A-SM-3NM8F GTEx Tissue Sample Gene Expression Profiles -1.0 -2.12883 ZNF135 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 80.4821 inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.946024 NCIH747 CCLE Cell Line Gene CNV Profiles 1.0 1.53176 GTEX-SN8G-0001-SM-3NM8L GTEx Tissue Sample Gene Expression Profiles 1.0 1.13667 GSE245270_1_v_3_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-H9-A6BY-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN013_HEPG2_24H:K03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0028 WC-09-GD62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.529658 ZFYVE9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06157 Lung squamous cell carcinoma_LUSC_TCGA-33-4566-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K39681206 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19673 OV7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.838544 CRCGN016_MCF10A.WT.HP_24H:E20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.26259 MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K52859120 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51519 HCC2218 Achilles Cell Line Gene Essentiality Profiles 1.0 2.13543 H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null male reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Multiple Myeloma DisGeNET Gene-Disease Associations 1.0 null insect GeneRIF Biological Term Annotations 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.07963 SNU449 CCLE Cell Line Gene CNV Profiles -1.0 -1.80615 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.826926 RL95-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null 20087356-TableS5 GeneSigDB Published Gene Signatures 1.0 null DGKQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00778 PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_HSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null cerebellar cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.24557 POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ED-81-ZH14_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.283625 K-562 cell ProteomicsDB Cell Type and Tissue Protein Expression Profiles 1.0 1.89253 STYX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78211 hel HPA Cell Line Gene Expression Profiles -1.0 -2.12606 BRD-K78596368_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null K562_Momelotinib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0197177 Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X585-0011-R1B-SM-46MVE GTEx Tissue Sample Gene Expression Profiles 1.0 1.13493 ATF3 ChEA Transcription Factor Targets 1.0 null GTEX-VJWN-0726-SM-3GIJ8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.826391 H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FB-66-UU47_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.446005 PMC6917500-elife-47110-supp1.xlsx-Table_J-Table_J_Differential_gene_expression_of_S-phase_invasion_cells_and_the_cells_treated_with_DMSO_SKI-73_and_SKI-73N_SKI Rummagene Transcription Factor Associations 2026 1.0 null renal proximal tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.212936 7507_RPS18_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.511639 MET_knockout_252_GSE30651 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.4243 superficial stratum of p3ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25938 primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.70777 IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3921 TargetScan Predicted Conserved microRNA Targets 1.0 0.006367 superficial stratum of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.69071 CRCGN012_HEPG2_24H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.19222 CPNE9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27473 PMC4332150-msb0011-0775-sd13.xlsx-JUN-Prey_Gene_Symbol_JUN Rummagene Transcription Factor Associations 2026 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ES-A2HS-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30016 hsa-miR-34b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 Cervix Carcinoma DisGeNET Gene-Disease Associations 1.0 null GSE239844_8_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00013 Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.WT.HP_24H:B22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.06226 MAFK_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Astrocytoma_CNS - Brain (MMHCC)_GSE4290 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.71236 BRD-K86285108 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06087 CRCGN010_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.71115 3054_FECH_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.803707 hsa-miR-30b TargetScan Predicted Conserved microRNA Targets 1.0 0.034317 SUM 52PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01576 MRPL58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60853 Intergeniculate leaflet of the lateral geniculate complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4403 GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30284 Shwachman-Diamond syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.23 BRD-K35119180 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07916 EFR3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00016 hsa-miR-4726-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 CRCGN015_MCF10A.WT.HP_24H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.53339 HB-06-WU12_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.230051 ribonucleoprotein complex subunit organization GO Biological Process Annotations 2015 1.0 null GTEX-O5YV-0008-SM-4E3HP GTEx Tissue Sample Gene Expression Profiles 1.0 0.92314 ZNF384 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 212.21 TYK-NU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01479 cellular component organization GO Biological Process Annotations 2015 1.0 null H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_EED226_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.020525 eye TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CRCGN013_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.65826 PMC9932992-mmc7.xlsx-S6D-Table_S6D_Per-gene_per-sample_AR_data_LCLs_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26199 TRIM28_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZG-0326-SM-47JXN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10326 GTEX-OOBK-1626-SM-2HMKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22031 orbital frontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10819 FB-39-CW59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.575305 GSE240027,GSE240030_1_v_2_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null 6219_PES1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.588832 LYSMD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00726232 15489895-Table5 GeneSigDB Published Gene Signatures 1.0 null RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.842235 KP2_PANCREAS CCLE Cell Line Proteomics 1.0 2.11342 BRD-K88328128 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66321 GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -2.06936 Anterior olfactory nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28835 MAFF ENCODE Transcription Factor Targets 1.0 null Intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.241 TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-LA-A446-01A-21R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.44052 H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GA-88-CF36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.274362 PMC9010637-mmc6.xlsx-5D-Figure_5D_Gene_Expression_Zhou_et_al_Application_of_SP3-Rox_to_identify_redox_changes_during_T_cell_maturation_SP3 Rummagene Transcription Factor Associations 2026 1.0 null BC-01-JL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.419582 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54D-01A-21R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE148193_1_v_0_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QEL4-1226-SM-447A4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.887372 GSE213228_1_v_5_irak2_human RummaGEO Gene Perturbation Signatures 1.0 null r8 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42751 GTEX-XMD1-0008-SM-4AT41 GTEx Tissue Sample Gene Expression Profiles 1.0 1.27846 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51N-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Dux JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.9883 cellular response to stimulus GO Biological Process Annotations 2015 1.0 null HES-3 ProteomicsDB Cell Type and Tissue Protein Expression Profiles -1.0 -1.01202 H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ATF1 ENCODE Transcription Factor Targets 1.0 null Choriocarcinoma DisGeNET Gene-Disease Associations 1.0 null H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JUN_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE95602_3_v_0_hsf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K46119789 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54782 GTEX-V1D1-0008-SM-4JBIJ GTEx Tissue Sample Gene Expression Profiles 1.0 3.66044 PK-59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00821 muscle GTEx Tissue Gene Expression Profiles -1.0 -2.01838 GSE161295_2_v_5_cdk8_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WZTO-3026-SM-3NMA2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17541 GTEX-Q2AG-0005-SM-33HBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08753 BRD-K54660148 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.26408 anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.904291 CEBPB_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K37431309 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27309 intrinsic component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.12594 SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null survival Phosphosite Textmining Biological Term Annotations 1.0 null ABCB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00589 hsa-miR-4764-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.039622 mantle zone of PalSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34386 GSE206516,GSE206518_5_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null posteroventral (inferior) parietal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.960246 ovary HPA Tissue Gene Expression Profiles -1.0 -0.848168 VD-76-SO91_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.296698 GSE239578_0_v_3_cxadr_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K13566078_HY-10518_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC5806898-pbio.2004411.s003.xlsx-MR_plot_data-Gene_names_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null cytoplasmic translational initiation GO Biological Process Annotations 2015 1.0 null GTEX-PWOO-1226-SM-48TCO GTEx Tissue Sample Gene Expression Profiles 1.0 1.02156 GTEX-XGQ4-0004-SM-4AT5S GTEx Tissue Sample Gene Expression Profiles 1.0 1.06908 BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.61001 BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN012_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5568 KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1-23762244-HIPPOCAMPUS-RAT ChEA Transcription Factor Targets 2022 1.0 null Perturb_10220_KO_TNFAIP6_ERP126958 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.41435 GSE129293_0_v_1_chd4_human RummaGEO Gene Perturbation Signatures -1.0 null parabigeminal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5602 BRD-K64860451 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45063 Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OE-01A-11R-A206-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null BC-14-CG34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.204212 hsa-miR-3658 TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 QE-79-XO29_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.617011 MDAMB361 CCLE Cell Line Gene CNV Profiles -1.0 -1.59773 BRD-K78813464 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3102 SCC-9 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.971 GPR18 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00567479 striatum_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.44359 UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.05602 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX Rummagene Transcription Factor Associations 2026 1.0 null GTEX-O5YW-0526-SM-2YUMX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.912649 16651414-Supp2 GeneSigDB Published Gene Signatures 1.0 null CA-48-SW47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.764148 GSE142210_9_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Dlx5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.2333 H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K42943023 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.13962 Developmental disorder of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.03 Eukaryotic translation initiation factor 4F complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.477 organelle disassembly GO Biological Process Annotations 2015 1.0 null GTEX-REY6-1326-SM-48FDO GTEx Tissue Sample Gene Expression Profiles 1.0 0.920083 POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.02463 GTEX-UPK5-1126-SM-3GAEJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.07595 Pax7 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.9164 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.9183 Paraventricular hypothalamic nucleus, magnocellular division, medial magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45229 KP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.19499 JARID1A-20064375-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null ribonucleoprotein complex assembly GO Biological Process Annotations 2015 1.0 null GA-88-CF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.48101 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN012_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.50725 GTEX-TML8-1326-SM-4DXTO GTEx Tissue Sample Gene Expression Profiles 1.0 0.881209 18593951-TableS2 GeneSigDB Published Gene Signatures 1.0 null Tumor Cell Invasion DisGeNET Gene-Phenotype Associations 1.0 null H3K9ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HOUAI DepMap CRISPR Gene Dependency 1.0 2.82931 Hmga1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 36.5419 H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HLA-B Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null dorsolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.927673 TE10 CCLE Cell Line Gene CNV Profiles 1.0 1.63829 DBTRG05MG DepMap CRISPR Gene Dependency 1.0 2.10062 hsa-miR-3182 TargetScan Predicted Conserved microRNA Targets 1.0 0.047969 posteroventral (inferior) parietal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.15427 RCOR1 ENCODE Transcription Factor Targets 1.0 null Infralimbic area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.0999 sin3a_22783022_mcf7_lof_human_gpl570_gds4388 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.277078 abnormal eye morphology MGI Mouse Phenotype Associations 2023 1.0 null hsa-miR-3646 TargetScan Predicted Conserved microRNA Targets 1.0 0.02226 CRCGN016_MCF10A.WT.HP_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.44281 GSE242290_1_v_10_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null CUX1 ChEA Transcription Factor Targets 1.0 null AD-29-IG16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.232101 GSE87404,GSE87812_2_v_3_hoxa9_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN009_HEPG2_24H:L08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.7703 SKMEL2 BioGPS Cell Line Gene Expression Profiles 1.0 1.29263 BRD-K41548770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3125 mantle zone of SePal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05616 BRD-K13488816 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1621 GSE87404,GSE87812_1_v_0_hoxa9_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE140651,GSE140653_2_v_1_med1_human RummaGEO Gene Perturbation Signatures -1.0 null S117 DepMap CRISPR Gene Dependency 1.0 2.29665 trochlear nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.61602 E2F1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null mantle zone of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03443 cell-cycle-proteins Phosphosite Textmining Biological Term Annotations 1.0 null GSE157609,GSE158123_0_v_1_ifi16_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RM2N-0726-SM-48FD5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.861577 Perturb_5430_OE_ATF3_SRP308440 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 18.1739 Bladder Neoplasm DisGeNET Gene-Disease Associations 1.0 null HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69297 paraventricular nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.87538 Cardiomyopathies CTD Gene-Disease Associations 1.0 1.05498 A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.74147 POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null regulation of growth GO Biological Process Annotations 2015 1.0 null TFAP2A-17053090-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SW 1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.44909 BRD-K81574470 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09079 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.742 GTEX-SIU8-0006-SM-2XCE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56966 Childhood Lymphoma DisGeNET Gene-Disease Associations 1.0 null Endocrine gland cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.207 SE-81-RI20_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.502006 POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03199 Parasolitary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03024 TOLEDO CCLE Cell Line Gene Expression Profiles 1.0 1.991 HUH28 CCLE Cell Line Gene Expression Profiles 1.0 2.78417 VCAP CCLE Cell Line Gene Expression Profiles -1.0 -2.08994 Brain Lower Grade Glioma_LGG_TCGA-P5-A72W-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null STPG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34609 POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWS6-2126-SM-2XCAV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26219 DD-74-PJ26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.362763 MAX_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-MEL-2 GDSC Cell Line Gene Expression Profiles 1.0 1.78192 BRD-K38858314 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34669 ONECUT3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 157.149 CREB3L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04303 H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K34489277 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46155 RAD21_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytoplasm LOCATE Curated Protein Localization Annotations 1.0 null CRCGN014_HEPG2_24H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.85845 PGRMC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00350355 BRD-K71460915 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01827 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q6-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.758 BRD-K43981353 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28623 TCF7L2_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WRHK-1726-SM-3MJFK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.834434 GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.970532 cerebellar cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.932887 chromosome GeneRIF Biological Term Annotations 1.0 null hsa-miR-500a TargetScan Predicted Conserved microRNA Targets 1.0 0.029271 TBP_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A67254212 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18512 GSE75209,GSE75212_0_v_1_halofuginone_mouse RummaGEO Drug Perturbation Signatures -1.0 null NCCSTCK140 CCLE Cell Line Gene Expression Profiles -1.0 -1.65882 Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2BK15ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GABPA_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CSK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00372574 GSE233679_6_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R3RS-0526-SM-3GADG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02027 GSE185944_2_v_1_pth1r_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K89040444 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22364 H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.87826 preoptic telencephalon Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51688 laterodorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17441 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4891-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_Triamcinolone Acetonide_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00720188 GTEX-UPIC-0002-SM-3NMDC GTEx Tissue Sample Gene Expression Profiles 1.0 2.14581 EDD_DEPLETION_GDS2445_116_human_embryonic fibroblasts GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35107 BRD-K37866276 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72558 coexpression GeneRIF Biological Term Annotations 1.0 null GTEX-X261-0011-R11A-SM-4E3JY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08092 GSE87404,GSE87812_2_v_0_hoxa9_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE223008_11_v_12_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null 2988_FBL_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.02957 CRCGN012_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6309 posteroventral (inferior) parietal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.33795 POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Glioblastoma DisGeNET Gene-Disease Associations 1.0 null H3K9ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null nrf1_22586274_liver_lof_mouse_gpl4134_gse35124 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.044154 MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Squamous Cell Carcinoma DisGeNET Gene-Disease Associations 1.0 null SIX5_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null positive regulation of cell proliferation GO Biological Process Annotations 2015 1.0 null CRCGN016_MCF10A.TP53.M_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.64435 KMS34 CCLE Cell Line Gene Expression Profiles 1.0 1.69362 Slow muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.104 SEMA7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05528 MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JE-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer II of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.849831 ZR7530 Achilles Cell Line Gene Essentiality Profiles 1.0 1.61788 DNAJC5B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00644447 LOXIMVI COSMIC Cell Line Gene CNV Profiles -1.0 -3.83684 BRD-K45845217 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.90704 GSE197850_4_v_0_glucagon_human RummaGEO Drug Perturbation Signatures -1.0 null MAX_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null S0-EE-YEKU_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.3219 hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08508 H3K4me3_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:L20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.03758 2988_FBL_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.561762 CRCGN008_HEPG2_24H:J08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.04115 SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Ensembl_ID_FOXM1 Rummagene Transcription Factor Associations 2026 1.0 null VCAP CCLE Cell Line Gene CNV Profiles -1.0 -2.09282 GSE133329_2_v_3_trim28_human RummaGEO Gene Perturbation Signatures 1.0 null AC-36-SY22_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.328642 H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null present GeneRIF Biological Term Annotations 1.0 null regulation of macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.14741 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6909-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158834_10_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_826_KD_REST_SRP093671 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.83397 H3K4me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE226408_1_v_0_inpp4b_human RummaGEO Gene Perturbation Signatures -1.0 null Hyperplasia CTD Gene-Disease Associations 1.0 1.54135 skeletal muscle cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 hsa-miR-1972 TargetScan Predicted Conserved microRNA Targets 1.0 0.23348 hsa-miR-3145-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.003282 GSE213588_10_v_5_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE205730,GSE205731_2_v_1_tazemetostat_human RummaGEO Drug Perturbation Signatures -1.0 null BMI1_DN_MEL18_DN.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null BRD-K82638914 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.0979 PMC8173714-NIHMS1678410-supplement-Supplementary_Table_2.xls-OfficialIPEXsig-Supplementary_Table_2_-_IPEX_signature_genes_with_their_average_IPEX_HD_fold_change_in_Tregs_and_Tconvs_FOXP3 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null PANC 04.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09201 BTN3A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00614495 preoptic alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51688 H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-1243 TargetScan Predicted Conserved microRNA Targets 1.0 0.49473 BRD-K57441129 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06056 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MH-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ASXL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88144 TEAD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UJHI-1926-SM-3DB8Z GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841485 SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.8587 GSE111247_2_v_6_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null PMC4486168-pone.0131961.s006.xlsx-Sheet1-ARID3B_Upregulated_Genes_ARID3B Rummagene Transcription Factor Associations 2026 1.0 null Adult Glioblastoma DisGeNET Gene-Disease Associations 1.0 null CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K16670438 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08626 GTEX-QESD-0006-SM-2I5G6 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.15214 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EZH2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00351365 Lymphoma DisGeNET Gene-Disease Associations 1.0 null NCI-H1155 COSMIC Cell Line Gene Mutation Profiles 1.0 null A172 Achilles Cell Line Gene Essentiality Profiles -1.0 -2.80454 CP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19312 pc3 HPA Cell Line Gene Expression Profiles 1.0 1.77042 MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CC-68-YZ44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.276069 Bronchial epithelium TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.21 HCC827 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.863641 COLO-684 GDSC Cell Line Gene Expression Profiles -1.0 -2.24074 H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K68869896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47221 GB-57-XV52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.436089 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 BRD-K56973599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10593 CRCGN013_HEPG2_24H:K12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.54116 colon_8b HPA Tissue Sample Gene Expression Profiles 1.0 1.04914 prevent GeneRIF Biological Term Annotations 1.0 null 14581339-SuppTable6 GeneSigDB Published Gene Signatures 1.0 null Skeletal muscle fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.104 Left middle cerebral artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.51 MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K30799912 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01034 BRD-K53612668 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43784 CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null transcription GeneRIF Biological Term Annotations 1.0 null GTEX-P4PQ-0005-SM-2HMKJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01973 H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HCC2302 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null BRD-K36852613 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32003 GTEX-T5JW-0926-SM-4DM5K GTEx Tissue Sample Gene Expression Profiles 1.0 0.866193 BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16625 ZNF143 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.0889 BRD-K84685162 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42357 EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null m2 part of nucleus parabrachialis pigmentosus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.50578 7501_RPS13_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.912645 H3K79me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K63761383 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94889 VI, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.22123 10703_ZNRD1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.526337 nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Shox2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 14.7389 hsa-miR-4729 TargetScan Predicted Conserved microRNA Targets 1.0 0.004732 ELK1::SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.4384 JHESOAD1 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.7353 hsa-miR-1298 TargetScan Predicted Conserved microRNA Targets 1.0 0.015875 GSE140997_4_v_7_nsun6_human RummaGEO Gene Perturbation Signatures 1.0 null Intracellular anatomical structure COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 hsa-miR-3713 TargetScan Predicted Conserved microRNA Targets 1.0 0.02452 PPARD-21283829-MYOFIBROBLAST-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-X261-0011-R5A-SM-3NMB4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826653 SP1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-39-5028-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FA-63-WI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.57314 MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A92490200 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16335 ventrolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.92043 H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE172146_2_v_0_mettl1_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21 ENCODE Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-6980-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.TP53.M_24H:P12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.07473 H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null pkc GeneRIF Biological Term Annotations 1.0 null POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Frontal pole, cerebral cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40844 central gray of the pons, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.53367 NANOG-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Basolateral cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.577 MM127 DepMap CRISPR Gene Dependency 1.0 5.68249 GSE139966_4_v_0_figla_mouse RummaGEO Gene Perturbation Signatures -1.0 null r9 portion of the hypoglossal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.86842 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A7IN-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.25376 TAF1_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 9962_ZBED2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.533999 IRF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral septal nucleus, intermedio-intermediate part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29413 Malignant astrocytoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.172 H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null LOX IMVI BioGPS Cell Line Gene Expression Profiles -1.0 -2.8634 CHD1 ENCODE Transcription Factor Targets 1.0 null connective tissue TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE42805,GSE42811_1_v_0_cocaine_mouse RummaGEO Drug Perturbation Signatures 1.0 null NE-94-VE83_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.291631 GTEX-RU1J-1726-SM-2TF5S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46281 Steatohepatitis DisGeNET Gene-Disease Associations 1.0 null GSE167224,GSE168147_3_v_5_hnrnpk_human RummaGEO Gene Perturbation Signatures -1.0 null cerebellar cortex_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.27381 increased circulating alkaline phosphatase level MGI Mouse Phenotype Associations 2023 1.0 null H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K27578003 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.39493 BRD-K59571728 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38842 GTEX-X88G-0004-SM-47JZ6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.43143 skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -0.889642 PD-94-WO47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.200815 ZBTB33_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE125014_6_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K80763723 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06568 intermediate stratum of m1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01927 organelle part GO Cellular Component Annotations 2015 1.0 null signal-regulated Phosphosite Textmining Biological Term Annotations 1.0 null FOXE1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 167.969 adipocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.170175 r4 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17308 BRD-K82107155 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15119 Spinal Muscular Atrophy, Infantile_CNS - Spinal Cord (MMHCC)_GSE3075 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.22822 GTEX-U3ZH-0002-SM-3NMDD GTEx Tissue Sample Gene Expression Profiles 1.0 2.23861 HDAC6 ENCODE Transcription Factor Targets 1.0 null Neuroblastoma DisGeNET Gene-Disease Associations 1.0 null BRD-K41189799 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07037 H3C11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33421 HPAC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.54923 hsa-miR-3680 TargetScan Predicted Conserved microRNA Targets 1.0 0.136254 GSE168918_1_v_0_tmprss4_human RummaGEO Gene Perturbation Signatures 1.0 null 2291_DNAJC17_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.643211 Oral cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.886 GSE120370_0_v_6_thrombin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-K7-A6G5-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null granular layer of rostral dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3651 GTEX-PVOW-2526-SM-2XCF7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.93337 cornea TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.144449 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.31206 BRD-K30025024 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05001 H3K27ac_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-A68739437_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GABPA_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AKT1_activemutant_9_GDS2304 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.74515 BRD-K38557431 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02247 biosynthetic process GO Biological Process Annotations 2015 1.0 null CRCGN013_HEPG2_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.52836 CRCGN016_MCF10A.WT.HP_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.76095 ELF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_8159_KD_MTPAP_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.02468 GSE203158_0_v_14_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OHPN-0011-R4A-SM-2I5FD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.967628 E2F1-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null KDM1A ENCODE Transcription Factor Targets 1.0 null Pallidum, medial region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11445 dorsolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.930455 GTEX-S7PM-0526-SM-3NM92 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.926905 PMC12260418-pnas.2425984122.sd02.xlsx-TEAD1_6fraction_test_result-Unnamed_3_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2822-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03069 HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03467 MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.19036 GSE124375_13_v_12_chd2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Appendix BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.959779 GSE126001_3_v_2_il13_mouse RummaGEO Gene Perturbation Signatures 1.0 null Slow twitch muscle fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.821 membrane GO Cellular Component Annotations 2015 1.0 null YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null sense organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null RCM1 CCLE Cell Line Gene Expression Profiles 1.0 1.52439 H3K9me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-WFON-0001-SM-3P61W GTEx Tissue Sample Gene Expression Profiles 1.0 1.49869 molecular layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.36582 BRD-K27416453 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25804 ELF1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.89388 K562_TGX-221_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.01596 hsa-miR-30c TargetScan Predicted Conserved microRNA Targets 1.0 0.034317 Perturb_15645_KO_Tet2_SRP255385 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 NERF1a MotifMap Predicted Transcription Factor Targets 1.0 null fat pad TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.162421 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RJ-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZP-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2073 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.62005 Arid3a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.963 SETDB1_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32604 FLO-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.00768 BRD-K36671227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.13124 GSE93309_5_v_4_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null 15656903-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null GSE111247_2_v_8_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K56276074 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49595 EE-98-PF86_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.737608 GTEX-XXEK-0004-SM-4BRWO GTEx Tissue Sample Gene Expression Profiles 1.0 1.35631 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Non-Small Cell Lung Carcinoma DisGeNET Gene-Disease Associations 1.0 null superficial stratum of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43958 inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.13806 Skin TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 GTEX-R55G-0126-SM-48FDS GTEx Tissue Sample Gene Expression Profiles 1.0 0.854125 EGR1 ENCODE Transcription Factor Targets 1.0 null TFEB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9946 HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17063 H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null signal Phosphosite Textmining Biological Term Annotations 1.0 null polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18655 6032_PAF1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.616619 NR2C2 ENCODE Transcription Factor Targets 1.0 null GTEX-WY7C-2426-SM-3NB2V GTEx Tissue Sample Gene Expression Profiles 1.0 0.849765 BRD-K97393725 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40808 hsa-miR-4775 TargetScan Predicted Conserved microRNA Targets 1.0 0.002088 dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.48051 PANC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.11253 IC-28-HS37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.233649 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null KDM5B ENCODE Transcription Factor Targets 1.0 null pharmacological Phosphosite Textmining Biological Term Annotations 1.0 null septopallidal transition area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05394 LC1SQSF CCLE Cell Line Gene CNV Profiles 1.0 1.796 BRD-A61014366 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.07359 displayed GeneRIF Biological Term Annotations 1.0 null E2F4 ENCODE Transcription Factor Targets 1.0 null GSE88819_5_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE164757,GSE164759_1_v_3_trametinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.26608 POLR2A_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.826926 GSE216043_10_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null JVE127 DepMap CRISPR Gene Dependency 1.0 2.17839 GSE135350_2_v_0_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null BronchialEpithelialCells BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.2379 GSE98898_4_v_1_hoxa1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XLM4-3126-SM-4AT6M GTEx Tissue Sample Gene Expression Profiles 1.0 1.65715 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K24132293_piperlongumine (HPLC)_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A689-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer VI of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.74301 DHX15 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN015_MCF10A_48H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.37948 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A6UM-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_UNC0631_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0166874 Chondrosarcoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE135350_3_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null Caov-4 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -4.27902 6581_POT1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.581122 GTEX-RWS6-0001-SM-3NMAL GTEx Tissue Sample Gene Expression Profiles 1.0 1.55674 H3K27ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HCC-1143 ProteomicsDB Cell Type and Tissue Protein Expression Profiles 1.0 0.91154 STAT3 ENCODE Transcription Factor Targets 1.0 null BRD-A75409952_wortmannin_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HEYA8 DepMap CRISPR Gene Dependency 1.0 3.19939 EA-18-FP00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.967836 H3K27ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null designated GeneRIF Biological Term Annotations 1.0 null CRCGN016_MCF10A.WT.HP_24H:O13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6342 BRD-K01266518 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52905 GTEX-X4XX-0011-R11A-SM-46MWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16684 K562_Resveratrol_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0239465 cytoplasm GO Cellular Component Annotations 2015 1.0 null KG-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.949324 SW 48 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.35086 PBX3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-451b TargetScan Predicted Conserved microRNA Targets 1.0 0.026857 lateral anterior hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.64449 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A459-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7797150__F4 PFOCR Pathway Figure Associations 2024 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-A67N-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K66254772_-666_MCF7_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 1441_CDK7_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.5628 A-375 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.59795 GTEX-QEG4-0006-SM-2I5FY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78373 ChIP_NANOG_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Perturb_3596_KO_DELE1_SRP218218 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.48027 Female reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.155 GSE140322_0_v_1_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PW2O-0126-SM-48TC8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.88303 TAF1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:K12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.00528 Nobox JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.6842 KG1C CCLE Cell Line Gene Expression Profiles 1.0 1.57307 BRD-K36063519 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27263 TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7443_RPL18_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.534876 RHOXF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.2149 periventricular stratum of r10Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.45619 POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rna biosynthetic process GO Biological Process Annotations 2015 1.0 null JHH1 DepMap CRISPR Gene Dependency 1.0 2.38911 7438_RPL14_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.576395 second (ventral) preoptic domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37313 SNU601 CCLE Cell Line Gene CNV Profiles 1.0 1.69113 GTEX-WWYW-1326-SM-3NB2S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.899457 protein-processing-post-translational Phosphosite Textmining Biological Term Annotations 1.0 null PIM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00518867 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null exposure Phosphosite Textmining Biological Term Annotations 1.0 null SIAH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.163 BRD-K69349031 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50895 LA-42-ER00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.263756 CHAGOK1 DepMap CRISPR Gene Dependency 1.0 4.20531 H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CALU-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.907995 first (dorsal) preoptic domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33744 amygdaloid complex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.24616 Stomach disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.021 AE-95-UU45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.208546 SNUC1 CCLE Cell Line Gene Expression Profiles 1.0 2.0083 SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Stat5a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.9453 CDK1 KEA Substrates of Kinases 1.0 null mcf7 HPA Cell Line Gene Expression Profiles 1.0 0.853414 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A634-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC4416014-pone.0125585.s010.xls-d_-BNC_network-Interactor_A_BNC1 Rummagene Transcription Factor Associations 2026 1.0 null regulation of nucleic acid-templated transcription GO Biological Process Annotations 2015 1.0 null H3K4me3_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null integral component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.138787 ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GA-28-SS67_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.352104 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KDM4A ENCODE Transcription Factor Targets 1.0 null BB-87-SF89_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.213574 JHOS-4 COSMIC Cell Line Gene CNV Profiles -1.0 -3.83684 GSE202434,GSE202438_3_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24028 BRD-K90736603 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.84726 Conventional (Clear Cell) Renal Cell Carcinoma DisGeNET Gene-Disease Associations 1.0 null PMC9714459-DataSheet3.xlsx-Supplement_3A-1166_common_elements_in_MSC_and_Fibroblasts_MSC Rummagene Transcription Factor Associations 2026 1.0 null Eukaryotic translation initiation factor 3 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.832 GTEX-X638-0005-SM-47JX6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10384 HeLa-S3 cell ProteomicsDB Cell Type and Tissue Protein Expression Profiles -1.0 -1.97436 PMC8384902-mmc5.xlsx-H128_PROX1_ChIP-Symbol_PROX1 Rummagene Transcription Factor Associations 2026 1.0 null cellular nitrogen compound biosynthetic process GO Biological Process Annotations 2015 1.0 null GSE226584,GSE226589_3_v_0_ezh2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-X5EB-0004-SM-46MWA GTEx Tissue Sample Gene Expression Profiles 1.0 1.27646 Childhood Osteosarcoma DisGeNET Gene-Disease Associations 1.0 null K562_Andarine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0172287 MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S33H-0826-SM-4AD5Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.995245 K562_Fasudil_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0167752 BRD-K71251432 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69164 HCC1187 DepMap CRISPR Gene Dependency 1.0 3.23426 GTEX-TKQ2-0826-SM-33HB6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.990816 central gray of the pons, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.886648 ZNF384_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GB-57-XV52_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.21999 2544_EIF3A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.60775 primary auditory cortex (core)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.943304 H3K79me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LI7 DepMap CRISPR Gene Dependency 1.0 3.55453 Endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.185 NUDUL1 CCLE Cell Line Gene CNV Profiles -1.0 -1.44567 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null intermediate stratum of r6BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03919 p53 GeneRIF Biological Term Annotations 1.0 null MAPK3 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K26094217 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20293 WC-09-GD62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.508337 ZMIZ1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CUX1 ENCODE Transcription Factor Targets 1.0 null MEL-HO GDSC Cell Line Gene Expression Profiles -1.0 -1.71799 oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.28207 17660535-TableS4c GeneSigDB Published Gene Signatures 1.0 null BRD-K36170990 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40012 FOSL2::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.6637 GSE96991,GSE97117_5_v_0_il11_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN016_MCF10A.WT.HP_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.20926 GTEX-N7MS-0007-SM-2D7W1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.86679 GTEX-TML8-0001-SM-3NMAF GTEx Tissue Sample Gene Expression Profiles 1.0 2.44353 cerebellar cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.23911 SK-N-DZ COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE151090_5_v_4_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null LD-69-ZV56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.217798 CAKI1 BioGPS Cell Line Gene Expression Profiles 1.0 0.953561 amygdaloid complex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.252 gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.088928 BRD-K89366873 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02755 BRD-K36252987 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.6879 BRD-K43414987 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7788 TAF1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5013636-ncomms12601-s5.xlsx-ETS2-Groups_ETS2 Rummagene Transcription Factor Associations 2026 1.0 null containing GeneRIF Biological Term Annotations 1.0 null outer SZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.911325 7477_RPL7A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.02208 ribonucleoprotein complex disassembly GO Biological Process Annotations 2015 1.0 null POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null t60-adrenal_consensus MoTrPAC Rat Endurance Exercise Training 1.0 2.56882 CRCGN017_MCF10A.TP53.M_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.71475 H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.94075 outer portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.983459 TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MFM-223 cell ProteomicsDB Cell Type and Tissue Protein Expression Profiles 1.0 0.850398 EE-98-PF86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.481937 Brain Lower Grade Glioma_LGG_TCGA-TM-A7C3-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC38_BREAST CCLE Cell Line Proteomics 1.0 4.48711 P3HR1 CCLE Cell Line Gene Expression Profiles 1.0 1.7035 GSE216043_10_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XOT4-0005-SM-4B64S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.971812 Perineurium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.566 NCI-H64 GDSC Cell Line Gene Expression Profiles -1.0 -2.16863 SUM185PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.938893 MITF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6881 PMC12211054-spectrum.00100-25-s0002.pdf-79-MAZ_MAZ Rummagene Transcription Factor Associations 2026 1.0 null BRD-K43126701 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51468 Perturb_4339_OE_ISL1/LHX3_SRP271657 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 14.384 CRCGN013_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.6034 Cardiac muscle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.222 SP1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K28274866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28606 cell part LOCATE Curated Protein Localization Annotations 1.0 null BRD-K32706281 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07568 hippocampus (hippocampal formation)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.31747 GSE165647_0_v_1_cry2_mouse RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of r3Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06211 purification GeneRIF Biological Term Annotations 1.0 null GSE242083,GSE242098_3_v_5_med1_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K25583354 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53533 CRCGN017_MCF10A.WT.HP_24H:I10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9153 BRD-K88038091 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79149 dorsolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.76021 protein-RNA complex assembly GO Biological Process Annotations 2023 1.0 null Perturb_4543_KD_Chd4_SRP126769 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.1483 GSE169152_5_v_2_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K27132686 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26395 Anterior olfactory nucleus, external part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29125 H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE217115_3_v_0_alectinib_mouse RummaGEO Drug Perturbation Signatures 1.0 null CRCGN017_MCF10A.TP53.M_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.87973 lung_4b HPA Tissue Sample Gene Expression Profiles -1.0 -0.910828 BRD-K38248167 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43672 menadione_mus musculus_gpl1261_gse23725 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC11383357-jciinsight-9-176383-s089.pdf-42-NFX1_NFX1 Rummagene Transcription Factor Associations 2026 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25X-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KB-92-MK13_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.21 Adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.229 LIN28A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42559 NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.32125 H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null RAB3A_Mutation - D77G point mutation_GDS2482_704_mouse_Hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57818 GTEX-NPJ7-0006-SM-3GACR GTEx Tissue Sample Gene Expression Profiles 1.0 1.08723 HS 895.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.01962 IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles -1.0 -0.920379 HCC1187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.62161 hsa-miR-1179 TargetScan Predicted Conserved microRNA Targets 1.0 0.140752 GTEX-S4Q7-1526-SM-3K2AG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.873706 HCC827 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12944 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8001-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE146982_3_v_1_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null 496100319_HIP_no dementia_TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.00614 EFNA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41964 r8 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24143 GSE205729,GSE205731_2_v_3_tazemetostat_human RummaGEO Drug Perturbation Signatures -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A8OC-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMURF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59445 H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PML ENCODE Transcription Factor Targets 1.0 null GTEX-UJHI-0008-SM-4IHL1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.56947 HNF1A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 73.4774 TJP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17397 POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.930518 throat TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.635167 GTEX-TMMY-1126-SM-4DXSX GTEx Tissue Sample Gene Expression Profiles 1.0 1.12374 CAL 54 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.44021 Perturb_7347_KD_ALKBH5_SRP070463 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.30353 dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.04216 dorsorostral division of MFC (area 32) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.827885 GABPA_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K23825243 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2574 TUBA1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17126 rna binding GO Molecular Function Annotations 2015 1.0 null H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cartilage TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K96417480 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21724 cellular component disassembly GO Biological Process Annotations 2015 1.0 null NFYB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Diabetes Mellitus DisGeNET Gene-Disease Associations 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZD-85-ND87_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.08396 GTEX-T6MO-1926-SM-32QOJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.859885 Large B-cell lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.281 GPRC5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20866 Infralimbic area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14977 SIN3A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDK1 Pathway Commons Protein-Protein Interactions 1.0 null UBC Pathway Commons Protein-Protein Interactions 1.0 null Liver Carcinoma DisGeNET Gene-Disease Associations 1.0 null POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K64763786 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.03788 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K81982648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39676 GSE81803,GSE81912_0_v_5_fmr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.0613 496100320_PCx_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.00045 Adenoma_Adrenal gland_GSE8514 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.68576 ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic Carcinoma DisGeNET Gene-Disease Associations 1.0 null GTEX-X638-0003-SM-47JZ1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.47129 U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11783 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.914379 BRD-K67478255 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78162 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.4064 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.78441 Cytosolic small ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.801 POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWOO-2026-SM-48TDE GTEx Tissue Sample Gene Expression Profiles 1.0 0.828477 H3K4me3_CD19 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null cd147 GeneRIF Biological Term Annotations 1.0 null premotor cortex (area 6) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.34644 OB-20-LP90_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.260991 H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skeletal Muscle Female Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.42802 ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.110396 GTEX-RU72-0006-SM-2TF65 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38103 NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.07384 H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-382 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 BRD-K98880643 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43606 Peripheral nervous system neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.046 MDA-MB-231 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.9012 Prostate GTEx Tissue Gene Expression Profiles 2023 1.0 3.14005 HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K71644199 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10927 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHPG-0004-SM-3NMDO GTEx Tissue Sample Gene Expression Profiles 1.0 1.41681 GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.942072 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZR-75 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.657 TRIM28_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A_48H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.06575 USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SF-0001-SM-3K2BE GTEx Tissue Sample Gene Expression Profiles 1.0 1.42554 SOX2 ChEA Transcription Factor Targets 1.0 null enlarged spleen MGI Mouse Phenotype Associations 2023 1.0 null GSE158320,GSE183351_0_v_3_lin28b_human RummaGEO Gene Perturbation Signatures 1.0 null RERFLCSQ1 CCLE Cell Line Gene CNV Profiles -1.0 -1.52135 superficial stratum of r2BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07124 Neurosphere_Cultured_Cells_Cortex_Derived Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.68906 GSE112365_0_v_1_sirt1_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN013_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0577 POLR2A_K562_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WZTO-0006-SM-3NM9T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.85725 cap-independent translational initiation GO Biological Process Annotations 2015 1.0 null GTEX-X261-3226-SM-3NMC3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.955918 BRD-K50400833 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24037 MAFK JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.153 TFAP2A-17053090-MCF7-human ChEA Transcription Factor Binding Site Profiles 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TFDP1_TFDP1 Rummagene Transcription Factor Associations 2026 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.874384 POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PGA1 DepMap CRISPR Gene Dependency 1.0 5.08146 BRD-K25942808 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08133 molecular layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.106 RB1_KD_GSE50532_659_human_OSTEOBLASTS GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PMC7576810-41419_2020_3099_MOESM9_ESM.xlsx-MS_analysis_EVI1-WT_vs_EVI1-S43-Unnamed_0_MECOM Rummagene Transcription Factor Associations 2026 1.0 null SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPV-0006-SM-2TF6Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52919 496100315_TCx_no dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.0788 anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.04824 Perturb_3594_KO_DELE1_SRP218218 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.34709 Prostate adenocarcinoma_PRAD_TCGA-EJ-A65D-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN011_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5998 MNT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1852 GTEX-PWCY-2226-SM-2S1OP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0485 CRCGN009_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.48522 SUMO1 Pathway Commons Protein-Protein Interactions 1.0 null RERFLCSQ1 DepMap CRISPR Gene Dependency 1.0 3.05733 ZD-18-MI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.256849 Perturb_2718_KD_BRD_SRP115100 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.15235 GTEX-OXRN-2626-SM-48TBX GTEx Tissue Sample Gene Expression Profiles 1.0 1.10087 AA-23-FM46_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.875102 ATF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.3272 GSE222598_1_v_0_sf3b4_human RummaGEO Gene Perturbation Signatures 1.0 null yy2_20215434_hela_lof_human_gpl570_gds3788 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.055517 Cervical Cancer DisGeNET Gene-Disease Associations 1.0 null SF172 Achilles Cell Line Gene Essentiality Profiles 1.0 1.52967 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3346-01A-01R-1766-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE264621_1_v_3_secretin_human RummaGEO Drug Perturbation Signatures 1.0 null BEN CCLE Cell Line Gene CNV Profiles -1.0 -1.64375 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-423 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10697 hsa-miR-4662b TargetScan Predicted Conserved microRNA Targets 1.0 0.103424 BRD-K73027631 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.4896 Fast twitch muscle fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.586 NCI-H196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.826209 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null multistage GeneRIF Biological Term Annotations 1.0 null Perturb_12294_KO_PKM_SRP322205 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE213153_1_v_0_ulixertinib_human RummaGEO Drug Perturbation Signatures -1.0 null MCF7_Filgotinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146856 EWS502 Achilles Cell Line Gene Essentiality Profiles 1.0 1.46695 cytoplasmic part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BF-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K60453579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02403 NME4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3579 NFYB ENCODE Transcription Factor Targets 1.0 null BRD-K76803075 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41849 RCOR1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WCDI-0002-SM-3P61U GTEx Tissue Sample Gene Expression Profiles 1.0 1.28294 Epilepsy DisGeNET Gene-Disease Associations 1.0 null EZH2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151612_4_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.14089 terminal nucleus of the stria medullaris Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.83861 GTEX-POMQ-1926-SM-3NB1Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.943617 Orbital area, medial part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30004 tonsil_8e1 HPA Tissue Sample Gene Expression Profiles 1.0 1.08272 regulation of nucleobase-containing compound metabolic process GO Biological Process Annotations 2015 1.0 null SMC3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_HEPG2_48H:P19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.01673 EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210885_2_v_7_klf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null r6 part of ventral gigangocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01767 GSE226770_1_v_0_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null PMC5031867-mmc2.xlsx-RYTTCCTG_V_ETS2_B-PROBE_ETS2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K31250130 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48269 BRD-K86463534 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50559 H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GABPA_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell-line-tumor Phosphosite Textmining Biological Term Annotations 1.0 null RAJI cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.98 BRD-K20142115 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01208 GC-04-UF36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.358216 OGFOD1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K26361872 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13017 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4074-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ovarian Neoplasms CTD Gene-Disease Associations 1.0 1.13997 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.33112 BRD-K76976010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55711 Bone cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE152432_6_v_0_zrsr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SOX2-18358816-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Perturb_3595_KO_HRI_SRP218218 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.1311 GSE172295_0_v_2_sh3gl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-4256 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 BRD-K31870622 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20833 HMEL CCLE Cell Line Gene Expression Profiles -1.0 -2.23263 H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KYSE-150 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.996602 6152_PDCD11_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.716312 ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.838544 Bladder disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.087 CDX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 51.7958 Knrk TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.055 GSE242290_3_v_11_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040732 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5C1-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE180641_0_v_1_zfp503_mouse RummaGEO Gene Perturbation Signatures 1.0 null periventricular stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.85642 GSE127790_10_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OXRO-1726-SM-3LK6C GTEx Tissue Sample Gene Expression Profiles -1.0 -0.830703 GSE227592_4_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null cerebellar cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.32943 ATIC Pathway Commons Protein-Protein Interactions 1.0 null BRD-K96393402 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44147 vitamin c_homo sapiens_gpl570_gds3635 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE96777,GSE96778_1_v_0_zbtb4_human RummaGEO Gene Perturbation Signatures -1.0 null MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CFPAC1_PANCREAS CCLE Cell Line Proteomics 1.0 9.17435 BRD-K10989535 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20493 CTCF ENCODE Transcription Factor Targets 1.0 null PUA domain InterPro Predicted Protein Domain Annotations 1.0 null GTEX-QLQW-1326-SM-2S1QS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.883696 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I2-06A-21R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amorolfine LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7183 Mesothelioma_MESO_TCGA-SC-A6LP-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DC-70-EK34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.326761 nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE88819_0_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-4769-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.187098 Crx JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.5299 MYLK_knockdown_49_GSE14525 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.15137 H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EFO27 DepMap CRISPR Gene Dependency 1.0 4.07158 GSE239844_4_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null r9 part of external cuneate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04458 loss GeneRIF Biological Term Annotations 1.0 null H2BK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-U8XE-0726-SM-3DB8O GTEx Tissue Sample Gene Expression Profiles -1.0 -0.833994 cerebellar cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.43439 H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JC-06-ED36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.869756 HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.64308 PMC4149371-pone.0105180.s010.xls-NANOG-GENE_NANOG Rummagene Transcription Factor Associations 2026 1.0 null IZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10009 Perturb_7370_KD_HNRNPC_ERP012939 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.76183 striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.90622 H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QXCU-1726-SM-2TC6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07153 ALMS1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00656759 ZSCAN4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.5836 H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45635 SYK_druginhibition_290_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.76641 BRD-K03506285 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06453 PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null cell periphery COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 skeletalmuscle_c HPA Tissue Sample Gene Expression Profiles -1.0 -0.846913 LOX-IMVI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -3.82124 peripeduncular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.98485 H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.16272 intermediate stratum of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04998 TCF7L2 ENCODE Transcription Factor Targets 1.0 null laterodorsal part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.914768 GTEX-QDVN-2226-SM-2S1PM GTEx Tissue Sample Gene Expression Profiles 1.0 0.88842 ZNF274 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.8783 sarcoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-T2IS-0226-SM-32QPH GTEx Tissue Sample Gene Expression Profiles 1.0 0.947882 D341MED CCLE Cell Line Gene Expression Profiles 1.0 2.876 H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K38434557 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13244 ventrolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.989657 BRD-K68347834 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25225 Weight Loss CTD Gene-Disease Associations 1.0 1.09332 H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null dorsal septopreoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03718 POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.166 ANAPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20518 Paraventricular hypothalamic nucleus, parvicellular division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01537 hsa-miR-576-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.02226 medial portion of STH Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.50715 BHLHE40 ENCODE Transcription Factor Targets 1.0 null mct1mct4 GeneRIF Biological Term Annotations 1.0 null GTEX-WL46-0626-SM-3LK7R GTEx Tissue Sample Gene Expression Profiles -1.0 -0.915443 15297395-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null SP in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.11377 H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T5JC-2526-SM-4DM6G GTEx Tissue Sample Gene Expression Profiles 1.0 1.05516 Posterior cingulate cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.688 facial motor nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.35588 MKN45 CCLE Cell Line Gene CNV Profiles -1.0 -1.37948 BRD-K58005972 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7188 GTEX-OHPL-0008-SM-4E3I9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05529 K562_Ofloxacin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0158261 JARID1A-20064375-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Papillary Renal Cell Carcinoma DisGeNET Gene-Disease Associations 1.0 null GSE148200_4_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE128730_3_v_1_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null membrane COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-P4QS-0326-SM-2I3EU GTEx Tissue Sample Gene Expression Profiles 1.0 0.881823 PROSC Pathway Commons Protein-Protein Interactions 1.0 null SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cytoplasmic part GO Cellular Component Annotations 2015 1.0 null GTEX-OHPN-0011-R11A-SM-2I5FM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.85889 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPK5-0006-SM-3GAD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28137 GTEX-UTHO-0011-R1A-SM-3GIJO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.895506 BRD-K59069382 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.92358 GSE217526_0_v_1_parthenolide_human RummaGEO Drug Perturbation Signatures -1.0 null Melanoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.117 AC-84-QG99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.906328 CCNT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00469067 2105_DDX18_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.641712 ERG ChEA Transcription Factor Targets 1.0 null A375SKINCJ1 DepMap CRISPR Gene Dependency 1.0 2.00936 Neoplasm Metastasis CTD Gene-Disease Associations 1.0 1.18652 hsa-miR-607 TargetScan Predicted Conserved microRNA Targets 1.0 0.088999 GSE202434,GSE202438_15_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null GTEX-WHSE-0011-R1A-SM-3P5ZK GTEx Tissue Sample Gene Expression Profiles 1.0 0.846089 H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CD3 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null APOL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00747311 POLR2AphosphoS2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW1990 GDSC Cell Line Gene Expression Profiles -1.0 -1.67298 Colorectal Carcinoma DisGeNET Gene-Disease Associations 1.0 null BRD-K16207265 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09152 hsa-miR-642a TargetScan Predicted Conserved microRNA Targets 1.0 0.065994 Bed nuclei of the stria terminalis, anterior division, dorsomedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04543 BRD-K29468949 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09837 HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.07299 icSARS-Cov_Day7_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.50089 H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_2565_OE_JUN_SRP188712 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.21158 CRCGN017_MCF10A.TP53.M_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.1095 GTEX-XV7Q-0226-SM-4BRVL GTEx Tissue Sample Gene Expression Profiles 1.0 1.03452 confirmed GeneRIF Biological Term Annotations 1.0 null BRD-K37527074 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02632 BRD-K36952018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16772 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mediodorsal nucleus of thalamus_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03578 Adult Lymphoma DisGeNET Gene-Disease Associations 1.0 null POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Neurogenic Muscular Atrophy_Muscle - Striated (Skeletal) (MMHCC)_GSE2566 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.53813 GTEX-XBEC-1326-SM-4AT69 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76733 BRD-K64268886 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48261 SCC-25 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.898 BRD-K99452971 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24904 PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null BRD-K50094173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8295 ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.45824 positive regulation of biological process GO Biological Process Annotations 2015 1.0 null hsa-miR-222 TargetScan Predicted Conserved microRNA Targets 1.0 0.181316 BRD-K83115645 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04347 Drug-Related Side Effects and Adverse Reactions CTD Gene-Disease Associations 1.0 1.31716 Liver Diseases CTD Gene-Disease Associations 1.0 1.03715 BRD-K05841284 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74979 DDX49 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57867 RUNX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29435 PLEKHO2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0056194 8272_SON_P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.510881 SMC3 ENCODE Transcription Factor Targets 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.837444 LOXIMVI GDSC Cell Line Gene Expression Profiles -1.0 -3.53725 7243_REXO2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.508058 H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null therapeutic GeneRIF Biological Term Annotations 1.0 null ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 2321_DNTTIP2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.564855 H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4777-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.004732 BRD-K82700281 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06942 CRCGN009_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9266 H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null Acute Kidney Injury CTD Gene-Disease Associations 1.0 1.03678 H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE117212,GSE117214_0_v_1_zbtb1_human RummaGEO Gene Perturbation Signatures 1.0 null mantle zone of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07717 Stomach Carcinoma DisGeNET Gene-Disease Associations 1.0 null BRD-K59606563 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51499 U251MGDM DepMap CRISPR Gene Dependency 1.0 3.19287 H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.842235 KDM5A ChEA Transcription Factor Targets 1.0 null GTEX-OXRL-0626-SM-3NM9C GTEx Tissue Sample Gene Expression Profiles 1.0 0.882368 hsa-miR-3160-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.09606 GTEX-X4LF-0006-SM-3NMCO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33069 BRD-K35520972 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08681 KC-48-OO62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.512712 thyroid BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.943927 BRD-K62555617 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35292 H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-330-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.082179 Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE154081_3_v_0_sildenafil_mouse RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6II-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE113734_1_v_2_qprt_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SJXC-0126-SM-2XCFF GTEx Tissue Sample Gene Expression Profiles 1.0 0.934447 emboliform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.55778 hsa-miR-590-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.205675 POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XGQ4-1326-SM-4GIDU GTEx Tissue Sample Gene Expression Profiles 1.0 1.02047 ChIP_SOX2_18692474 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null EPHA4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00475963 amygdaloid complex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.833703 7566_RRP7A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.539407 PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredPeptides-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null PANC 05.04 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.875673 regulation of transcription, dna-templated GO Biological Process Annotations 2015 1.0 null H3K56ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null inner CP in midlateral extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09429 BRD-K15019832 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9519 BRD-K42654859 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.00577 SAOS2 BioGPS Cell Line Gene Expression Profiles -1.0 -1.0959 GTEX-N7MS-0011-R1a-SM-2HMJG GTEx Tissue Sample Gene Expression Profiles 1.0 1.1628 GTEX-NL3H-0011-R5a-SM-2I3GB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.880741 Perturb_2516_KD_YAP1_SRP181909 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.83479 GTEX-TSE9-0526-SM-3DB7Z GTEx Tissue Sample Gene Expression Profiles -1.0 -0.902958 2553_EIF3I_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.509045 GTEX-SUCS-0002-SM-3NMAJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.55481 5470_NAT10_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.698874 plasma membrane COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 r3 part of the trigeminal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06152 BRD-K70851916 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42345 APOH LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00485387 ELK4 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-P5-A77X-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE165647_2_v_1_cry2_mouse RummaGEO Gene Perturbation Signatures -1.0 null AE-51-ZO26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.240238 LIG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06226 dorsolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.30834 BRD-K31546068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44648 hippocampus (hippocampal formation)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.993196 HB-06-WU12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.907272 ribonucleoprotein complex GO Cellular Component Annotations 2015 1.0 null POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.35669 PMC5013636-ncomms12601-s5.xlsx-LEF1-Groups_LEF1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE153189_2_v_0_stat1_mouse RummaGEO Gene Perturbation Signatures 1.0 null caudal linear (raphe) nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64573 raphe magnus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.983 HTC-C3 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.91427 maximum GeneRIF Biological Term Annotations 1.0 null skeletal muscle TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null bone marrow HPA Tissue Gene Expression Profiles -1.0 -0.981588 SLC35B2 Pathway Commons Protein-Protein Interactions 1.0 null 7462_RPL35A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.516297 CREB1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE132948,GSE132949_4_v_3_msi2_mouse RummaGEO Gene Perturbation Signatures 1.0 null NEC8 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.1288 hypoglossal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14199 3978_HSPA5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.568833 ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.63615 H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null