association	dataset	threshold value	standardized value
BRD-K05549579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28116
HPAF-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.609
RERFLCMS_LUNG	CCLE Cell Line Proteomics	1.0	3.18787
MCF7_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158185
GSE223540_0_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174393
GSE218727_2_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
YC-45-JD42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.26739
Cystathioninuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
WDR36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28826
GSE122215,GSE122217_0_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5083
BRD-K02749944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92567
BRD-K35829399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31952
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100352_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.59546
GSE134896_0_v_7_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-84-QG99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.54574
496100349_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.93847
BRD-K66222602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20101
hTERT-HPNE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.74
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.490157
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1496
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Nearest_Ensembl_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234289_4_v_0_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122067_3_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K26127722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4924
CRCGN009_HEPG2_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06465
BRD-K80577041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19022
A549_CUDC-101_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0107468
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE123689_1_v_0_cbx8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9975
BRD-K23029982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74671
regulation of cell motility	GO Biological Process Annotations 2025	1.0	null
BRD-K22280519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67139
BRD-K36718828	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29829
Mean spheric corpuscular volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.0301
A549_Ellagic acid_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115446
BC-09-JG96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258727
FA-63-WI26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326254
RGS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0185
GSE226249_5_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K27951502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53885
CRCGN015_HEPG2_48H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.64408
BRD-K44512951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10381
OARD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10004
COQ4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3726
BRD-K59587063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5784
GSE152246_0_v_1_dihydrotestosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
lysosome	GO Cellular Component Annotations 2025	1.0	null
CRCGN010_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71108
PMC11067031-pnas.2317690121.sd06.xlsx-gene_list_14_txt-Differentially_expressed_genes_between_PML_RARA_GFP_vs_C88A_PML_RARA_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K07895476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15782
abnormal skin morphology	MGI Mouse Phenotype Associations 2023	1.0	null
Intercalated cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.602
CRCGN015_HEPG2_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.75712
NLRP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19305
BRD-K56126872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07196
HKDC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00527757
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.909585
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.8384
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K26552461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16012
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K12399715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19311
GSE179880_9_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Resveratrol_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145887
GSE57871_5_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FA-89-PW29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212922
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.369
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.55095
BRD-K57014223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21497
PMC4599908-pgen.1005526.s016.xlsx-TableS8-Overlap_of_FOXO3_direct_targets_from_Eijkelenboom_et_al_Molecular_Systems_Biology_2013_with_clusters_R_and_Q_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE206226_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.3272
A549_Maraviroc_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015446
BRD-K38788176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38018
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE225869_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE234514,GSE234516_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246929
STK235555	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
GSE160817_2_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_6_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49898
GSE242333_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HD-62-KE69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223927
ALDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85758
GSE164483_2_v_0_venetoclax_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GCIY	DepMap CRISPR Gene Dependency	1.0	4.05408
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33173
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.7658
AC-83-LN99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324562
PMC12339377-41587_2024_2403_MOESM3_ESM.xlsx-TableS6_LPS_screen_GEPs-Unnamed_26_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
furafylline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04072
TTC642	DepMap CRISPR Gene Dependency	1.0	2.95036
GSE178714_3_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235425
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.0169
BF-22-EP86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267793
PMC4609150-13073_2015_228_MOESM2_ESM.xlsx-TP53-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-Hela_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.486
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
response to insulin	GO Biological Process Annotations 2023	1.0	null
GSE57871_8_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.91698
BRD-K71424148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01104
PMC10534007-Table_2.xlsx-S6_unique_down_MSC_B-914_elements_included_exclusively_in_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233183,GSE233187_3_v_6_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NE-34-OZ69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230215
CRCGN010_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.30911
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K88003497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07698
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2685
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
response to nutrient levels	GO Biological Process Annotations 2023	1.0	null
ZNF16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01936
496100453_HIP_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.63294
GSE116930,GSE116935_1_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
response to amino acid	GO Biological Process Annotations 2025	1.0	null
BRD-K22564762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03148
GSE120413,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12663032-mmc7.xlsx-Supp_T6-Supplemental_Table_6_Dual_treated_vs_vehicle_treated_MSC_top_DEGs_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Metabolite levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.522185
ZGPAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06079
BRD-K44123761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72088
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8073
BRD-K17705318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51068
GSE168797_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83054
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222042
GSE151782_4_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K88890050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40141
PMC11426526-ppat.1012555.s011.xlsx-DEG_MDDC_Jurkat_LPS_vs_MDDC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SKNAS_AUTONOMIC_GANGLIA	CCLE Cell Line Proteomics	1.0	2.49604
GSE202434,GSE202438_10_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:J15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.14405
GSE223008_6_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.3706
PMC9894241-pnas.2211429119.sd05.xlsx-G4_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
MAPKAPK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15115
496100520_HIP_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.57579
chr16_84502184_C_G_b38	GTEx eQTL 2025	1.0	3.90503
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.88336
CCC5	DepMap CRISPR Gene Dependency	1.0	4.66597
BRD-K18332967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51532
Bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE248045,GSE248046_0_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_6_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139462
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.628289
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.77687
CRCGN015_HEPG2_48H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.46996
GSE48812_7_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.812237
BRD-K91387865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43666
BRD-K69229416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58341
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136143
GSE188458_2_v_0_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148066,GSE157787_8_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.9531
BRD-K83272071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65409
Kidney	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE234289_4_v_1_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K92520489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15481
Parathyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
AURKAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63102
CRCGN016_MCF10A.WT.HP_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45345
BRD-K51546355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05189
BRD-K76803075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63873
CRCGN011_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.87948
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.773163
TEAD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9819
CRCGN017_MCF10A.TP53.M_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96403
GSE139455_7_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A62469171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29008
GSE220942_2_v_1_galnt7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RCCFG2	DepMap CRISPR Gene Dependency	1.0	2.17323
RAVE complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.816
BRD-K24382357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13943
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.47104
GSE48812_3_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CAMA1	DepMap CRISPR Gene Dependency	1.0	3.18001
BRD-K45350681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29565
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240005
TF1	DepMap CRISPR Gene Dependency	1.0	2.29888
BRD-K98529522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12175
CRCGN017_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80511
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.872361
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3948
GSE48812_3_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE94011_0_v_3_pias3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
PANC0203_PANCREAS	CCLE Cell Line Proteomics	1.0	2.2423
CB-55-AK76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.398308
BE-92-TW08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304595
GSE89018_12_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TA-34-CK62_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.411834
RBPJ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7344
GSE176008_7_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nucleus	GO Cellular Component Annotations 2025	1.0	null
BRD-K27050140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28187
GSE173282_1_v_0_marchf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_11_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NSC43673	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.52
CRCGN014_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.27285
GSE138672_4_v_3_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_15_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SMCO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27341
AE-42-HT01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260935
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.60031
CRCGN010_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10466
GSE168797_1_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.46007
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_1_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
MYF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53753
BRD-K20520611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21185
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.534
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184902_3_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229973_4_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1499
GSE229973_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_UP_AA_UP-D-HEP3_UP_AA_UP_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-58-PW17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281208
PMC6360815-supp_gr.239053.118_Supplemental_Table_S2.xlsx-MAFs_targets-Table_of_potential_MAF_targets_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148252_2_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44887
GSE48812_8_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE184902_3_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.62448
OC-10-FB51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236968
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-85-JR73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.354157
5762_NPAT_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.14452
GSE86507,GSE86509_0_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-68-TC79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303982
Leukemia	DisGeNET Gene-Disease Associations	1.0	null
BRD-K65705295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00089
GSE215086_8_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A06837695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14055
PMC10318747-12864_2023_9472_MOESM2_ESM.xlsx-OCI-AML3_30min_vs_Control-Unnamed_1_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_SRT3025 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130204
BRD-K57035236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34287
BA-53-FM66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.313241
PMC6113333-41598_2018_31192_MOESM11_ESM.xlsx-Sheet1-H1_NFIC_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE238018_3_v_5_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
UMI-77	DeepCoverMOA Drug Mechanisms of Action	1.0	0.63
WC-16-IR43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336044
AE-13-CX28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.529874
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
CENPP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65008
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00371
GSE95302_2_v_3_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-43-ZC52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.388587
SCCOHT1	DepMap CRISPR Gene Dependency	1.0	6.37911
MKN28	DepMap CRISPR Gene Dependency	1.0	4.37399
BRD-K79562803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37653
GTEx AdiposeTissue 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	1.0	6.64282
BRD-K38358574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34915
GSE215086_8_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSTA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06164
CME1	DepMap CRISPR Gene Dependency	1.0	3.98523
BRD-K77578964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03419
PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE168676_2_v_3_dach1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE243552_1_v_0_gpr107_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131649_6_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226249_2_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50264
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8603
GSE231875_0_v_1_zbed3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GAPDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46405
HCC1143_BREAST	CCLE Cell Line Proteomics	1.0	2.49373
GSE224157_2_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100402_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.3404
DD-54-MA35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301435
GSE185519_1_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Specific language impairment	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.435
BRD-K78995236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81253
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K71141540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18898
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Manchette	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.549
BE-73-KD75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.493012
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K09560946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.095
BRD-K82729465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37426
SHF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24131
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
KU1919_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	2.3311
GSE201309_1_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.29
PMC11385078-jciinsight-9-172336-s278.xlsx-Sheet1-Supplementary_Table_4_A_Differential_proteins_from_AA_BLCA_and_EA_BLCA_tissues_using_mass_spectrometry_based_proteomics_analysis_from_Figure_1C_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211357_2_v_0_atg7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193993_5_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K50946180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60348
BRD-K13927197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10611
GSE175787_13_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.1098
PMC11385078-jciinsight-9-172336-s272.xlsx-1DEseq2_Report_AA_BL_vs_EA_BL-Unnamed_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274693
abnormal epididymis morphology	IMPC Knockout Mouse Phenotypes	1.0	null
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.12998
GSE239844_11_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
B3GAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05758
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
response to peptide hormone	GO Biological Process Annotations 2023	1.0	null
GSE160817_3_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0367
GSE168233_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K40001470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38117
GSE202434,GSE202438_9_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178714_1_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LD-69-ZV56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289977
GSE178714_6_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE96649_1_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00940119
BRD-K80109782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37695
BRD-K32231853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54917
GSE182680,GSE182683_10_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE134896_0_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100347_PCx_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.61062
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_3_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240583
BRD-K89697867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1296
DU4475	DepMap CRISPR Gene Dependency	1.0	4.29496
AE-19-BK71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23147
JHUEM1	DepMap CRISPR Gene Dependency	1.0	6.67641
OC-71-BZ81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.368645
PMC9380317-13045_2022_1327_MOESM3_ESM.xlsx-Table_S7-Table_S7_Top_500_differentially_modified_gene_bodies_between_MM_and_its_precursors_in_AA_patients_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30298864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43066
BRD-K47906308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26106
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TE-15-RO34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.482824
EF-01-LB20_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308258
DA-20-VR86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200086
GSE149000_2_v_0_cyp3a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50859531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44248
GSE161846,GSE161849_3_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K67980271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61568
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.481509
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.435163
CRCGN015_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52986
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09028
AF-72-PP21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29868
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251085
BRD-K74040368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2078
MCF7_S-Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134753
SERTAD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2076
BRD-K42650945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27878
SA-32-CC58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229654
GSE44157,GSE44163_1_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE197257_0_v_1_gpd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266716
GSE139348,GSE139349_1_v_0_dicer1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-17-CS60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202414
GSE199081_0_v_1_insr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JF-96-HH81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.486124
TRIM47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04878
NFATC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0041758
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K26612358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27911
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1552
BRD-K39406901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41139
GSE215086_3_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE113817_2_v_1_bach1_human	RummaGEO Gene Perturbation Signatures	1.0	null
22RV1	DepMap CRISPR Gene Dependency	1.0	2.79855
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_6_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8377
BRD-K48046422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11932
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.630976
BRD-K77173942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80074
GSE207787_1_v_4_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE89018_12_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCOF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05393
UC-58-DM11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.320944
BRD-K43628610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4891
BRD-K75595810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12696
A549_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00935938
PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-SMAD3_target_genes_A549_SMAD3	Rummagene Transcription Factor Associations 2026	1.0	null
Bendamustine_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0142238
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301298
BRD-K70343553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0345
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3N_Peaks_YAP1FAM118B_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K99873441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29301
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8783
PMC12629827-mmc8.xlsx-DDR2_KD-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SMG9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30812
BRD-K18208847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27508
AB-18-YN11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286371
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.34163
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE248887_0_v_1_dkk1_human	RummaGEO Gene Perturbation Signatures	1.0	null
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.428692
GSE146982_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Danusertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.00975722
regulation of protein localization to lysosome	GO Biological Process Annotations 2025	1.0	null
CH157MN	DepMap CRISPR Gene Dependency	1.0	2.50026
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24304
GSE130715_2_v_3_budesonide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SRSF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52541
AE-71-CB15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268337
Martsolf syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.789
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.0869
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.674016
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredProteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Lysosomal membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2754
BRD-K16888026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41231
Excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC16A7+ cell_Lung_Human	CellMarker Gene-Cell Type Associations	1.0	null
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287535
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201761
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K17133642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16143
PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_13_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
FAM174C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07218
Brain - Caudate (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.49058
PMC11239565-uxae032_suppl_supplementary_data_s1.pdf-5-ZNF76_ZNF76	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30558628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72283
PNISR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73249
BRD-K98086832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07276
BRD-K08939947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61891
GSE201309_1_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chr16_84494629_T_C_b38	GTEx eQTL 2025	1.0	1.15979
BRD-K72647169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2624
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE145628,GSE145629_1_v_0_myrf_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST18-Supplementary_Data_18_Gene_burden_for_deletions_by_subtype_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.24617
FC-20-EQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225347
BRD-K07160586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1579
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.35472
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_4_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nevirapine_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00459054
GSE142210_2_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FF-22-NB12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259949
GSE132369,GSE132371_4_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A61046366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67538
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K57497543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49014
GSE132369,GSE132371_5_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE143512,GSE143513_0_v_1_nr4a3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K28919392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61463
BRD-K27111500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13637
GSE110268_2_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.661898
FC-40-QD52_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.392638
CRCGN016_MCF10A.WT.HP_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.13585
GSE167224,GSE168147_1_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	1.0	null
BE-31-XV38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25186
BRD-K31363949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10415
RHOXF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.8133
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
THRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71734
UMUC9	DepMap CRISPR Gene Dependency	1.0	2.22775
chr16_84486474_T_C_b38	GTEx eQTL 2025	1.0	1.49262
PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
CUL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00678563
BRD-K78812892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.57534
GSE235701,GSE261434_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K16496140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14794
BRD-K00446585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02747
BRD-K20271299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17828
BRD-K29969800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02045
abnormal skin morphology	IMPC Knockout Mouse Phenotypes	1.0	null
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_UP_NR2F1_ind_UP-D-HEp3_UP_NR2F1_Ind_UP_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
DA-10-GX45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273503
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12713692-mpa-55-e82-s009.xlsx-KRT81__vs_HNF1A-Gene_Name_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K51787437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39886
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.7078
GSE225869_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08668
MITD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03475
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20-D3_1775_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K89174739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08902
BRD-K19066553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02159
GSE48812_7_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of cell population proliferation	GO Biological Process Annotations 2025	1.0	null
BRD-K69252983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15724
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SAMD4B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00366584
GSE157594_5_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of protein localization	GO Biological Process Annotations 2025	1.0	null
MTHFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01076
BRD-K88190816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55331
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K86986466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28951
GSE77108_3_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
RF-04-GI28_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271498
A549_Epothilone A_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174447
BRD-K48676303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02481
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.29073
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236492
PMC6167382-41467_2018_6258_MOESM4_ESM.xlsx-TEAD-associated_GSC-Specific_UP-Nearest_Ensembl_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1929
Neutrophil count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.21549
EIF2S3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35991
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SLC29A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21258
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5941
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.535046
PMC11282827-40659_2024_524_MOESM5_ESM.xlsx-NR4A2-sequence_name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE209601_2_v_3_mef2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157594_3_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SEC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22397
BRD-A57474391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22776
GSE77108_4_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FAM117B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1208
GSE149359_2_v_1_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11328671-jitc-12-4-s003.pdf-403-TIGD6_TIGD6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-fig-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7849
GSE48812_11_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NUP93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85242
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
interleukin-4 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.911
BRD-K46120925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19316
BRD-K86578973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2052
CRCGN012_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61962
PMC6928094-395_2019_765_MOESM7_ESM.xls-DEGs_AR7_vs_Pre-patterned-List_of_differentially_expressed_genes_in_AR7_vs_Pre-patterned_cells_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
TGFBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01894
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_10_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67794
BRD-K97237010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06562
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.928576
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K41878930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40415
Myeloid white cell count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.3
GSE234514,GSE234516_2_v_0_mitf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135400_1_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
succinylcholine-chloride	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30348
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.40254
CRCGN009_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34483
AURKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02634
TA-19-YA45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.400375
PNT-1A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.571
abnormal lung morphology	IMPC Knockout Mouse Phenotypes	1.0	null
CRCGN015_HEPG2_48H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93948
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6165
BRD-K93945680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19567
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215086_4_v_7_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164529_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10164
G402	DepMap CRISPR Gene Dependency	1.0	6.25642
BRD-K92246187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43616
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Gene_Name_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K57184137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31019
CRCGN015_HEPG2_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.33484
ACTN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14967
A549_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015549
JD-62-HR05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249212
CRCGN017_MCF10A.TP53.M_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24561
BRD-K37975989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08394
GSE149903_4_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WF-96-ME07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.470495
FB-33-LI31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30486
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248132
chr16_84483682_C_T_b38	GTEx eQTL 2025	1.0	1.23613
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.22902
BA-46-YF32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320585
GSE157904_0_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE121809_1_v_0_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.480403
CRCGN014_HEPG2_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.57945
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K20624967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85045
GSE202434,GSE202438_8_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K18452866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59337
PMC11358385-41598_2024_70358_MOESM1_ESM.pdf-32-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246087
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_2_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.954
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-AA_up_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE163275_1_v_0_irf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154577_7_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2061
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.04534
QE-18-WG07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262995
BRD-K44152881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73122
GSE182680,GSE182683_5_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GD-82-CS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207846
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2169
BRD-K68492420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43612
CRCGN015_HEPG2_48H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58574
BRD-K88485670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01457
GSE57871_6_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.52779
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K02199688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06627
BRD-A52510783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44
GSE225869_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
AK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1117
DD-08-NW42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265578
CRCGN013_HEPG2_24H:B07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.34701
PRPF40A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51822
GSE193751_1_v_3_oridonin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184892_6_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.90014
CRCGN015_MCF10A.TP53.M_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28555
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207036
BRD-K58220038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57617
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K28347985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55746
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7583
GSE207611,GSE207612_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LN319	DepMap CRISPR Gene Dependency	1.0	3.7849
XE-29-LT20_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294011
BRD-K97081185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24789
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
S462	DepMap CRISPR Gene Dependency	1.0	2.92896
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHLA266	DepMap CRISPR Gene Dependency	1.0	2.25105
BRD-K48899005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86874
GSE227592_4_v_1_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K88292241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01731
NGP	DepMap CRISPR Gene Dependency	1.0	3.00562
BRD-K31765411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14034
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146982_4_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE179880_1_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.3246
BA-39-HG26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.435013
Contractile vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.715
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.23849
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14581
AC-84-QG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.4366
4EGI-1	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
GSE100102_4_v_3_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215849_2_v_1_muc1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K72261386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21014
TPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4637
PMC12619835-41467_2025_66007_MOESM12_ESM.xlsx-KLF5_activated_H3K27ac_T3M4-Nearest_Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K45563993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.35339
Prostate	GTEx Tissue Gene Expression Profiles 2023	1.0	3.84003
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K12612468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40527
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218060_7_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Ensembl_ID_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Upregulated_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
SPEG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03206
RPL26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31932
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9173
MKN45	DepMap CRISPR Gene Dependency	1.0	2.64468
GSE188570,GSE188571_5_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PORCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54394
AsPC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.815
GSE108084_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K60430111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3919
CRCGN012_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67925
XC-81-LR46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.2206
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.5861
nucleolus	GO Cellular Component Annotations 2023	1.0	null
BRD-K24393110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18552
BRD-K71671197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75566
GSE193999,GSE194000_3_v_2_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K10452371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29303
WAOSEL	DepMap CRISPR Gene Dependency	1.0	2.96602
BRD-K24598235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05107
chr16_84507275_T_C_b38	GTEx eQTL 2025	1.0	1.07877
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF518A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32188
ZBTB41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15703
SH4	DepMap CRISPR Gene Dependency	1.0	2.62567
BRD-K79318959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21559
Plateletcrit	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.1699
GSE198165,GSE198166_9_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.62508
GA-94-MC54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333573
GSE77795_2_v_1_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CF-24-KQ98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.350146
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-ID_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.766917
GSE104508_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
QA-34-PH05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293725
GFM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10821
GSE160817_7_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K04443775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91419
BRD-K34677894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49168
CLSPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45041
FC-40-QD52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214685
SLC7A14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00621526
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345664
GSE154577_6_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224311_3_v_0_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DE-62-FI29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.458506
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.3462
GSE199255,GSE199356_6_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NA-16-OJ70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301316
CRCGN009_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2653
Pitavastatin (Calcium)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0103689
CRCGN016_MCF10A.TP53.M_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75803
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCDC92B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13399
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BF-49-QA17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.447522
regulation of cell population proliferation	GO Biological Process Annotations 2023	1.0	null
FIGNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3032
Contractile vacuole complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.6
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K67556876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.53918
BRD-K42400613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1836
CRCGN015_MCF10A.TP53.M_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2758
GSE202434,GSE202438_3_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.24778
496100592_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.62763
BRD-K80166820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26797
GSE131798,GSE131804_1_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178267_2_v_4_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NB-80-IM48_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353632
GSE160246_2_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
F5	DepMap CRISPR Gene Dependency	1.0	5.25976
GSE224969,GSE224971_0_v_5_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K38615567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16183
BRD-K79876173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0318
GSE185519_6_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE245270_1_v_5_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2265
MN-64	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
GSE202434,GSE202438_12_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1742
BRD-K68333644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01235
PMC10274745-media-4.xlsx-S3A-Table_S3_Reanalysis_of_publicly_available_data_to_identify_AR_and_ER_direct_target_genes_related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K91885806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13665
TORC2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.36
GSE224439_1_v_3_adagrasib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chr16_84477025_A_G_b38	GTEx eQTL 2025	1.0	1.24564
Lysosomal membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.405
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219962
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.34935
BRD-K29713418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12144
MA-31-VM30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22716
GSE96649_1_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H4	DepMap CRISPR Gene Dependency	1.0	4.15942
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
PMC2813300-pone.0008960.s011.xls-SOX2_squamous_signature-Gene_Symbol_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE133329_0_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
OF-05-CB18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.64936
Lymphocyte Count Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
Monocyte count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	3.6699
Myosin X complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.156
BRD-K65207153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81575
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07363
GSE225869_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182179_5_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PYGM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02543
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EF-85-DA07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218089
PMC8901773-41598_2022_7986_MOESM3_ESM.xls-PIO_vs_LPS-Gene_symbol_ENSEMBL_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE245418_0_v_2_cd109_human	RummaGEO Gene Perturbation Signatures	-1.0	null
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.311
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217452_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH841	DepMap CRISPR Gene Dependency	1.0	4.42616
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.86019
CRCGN012_HEPG2_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46723
WM115_SKIN	CCLE Cell Line Proteomics	1.0	5.95642
CMK115	DepMap CRISPR Gene Dependency	1.0	4.43359
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LE-80-BM08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25428
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.445271
K562_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117089
BRD-K97332312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73156
DA-35-DU85_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204022
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.8358
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3N_Peaks_YAP1FAM118B_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K83438939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48781
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9097
MEF2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08237
CRCGN009_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.14
GSE89018_11_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
D502MG	DepMap CRISPR Gene Dependency	1.0	2.85931
BRD-K82658511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16187
GSE133329_2_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.808592
chr16_84477719_G_C_b38	GTEx eQTL 2025	1.0	1.21589
GSE133764_2_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MF-11-EW49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311706
MCF7_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130392
Epididymal clear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.088
ZNF382	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.0539
TLX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01363
GSE114258_1_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.59385
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.04411
A549_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150773
DUSP28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40094
HE-80-BQ08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.362583
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.55356
GSE149035_2_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K71499752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70703
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201351
PMC3371315-NIHMS350140-supplement-13.xls-MCF7-T47D-SK-453_Up_Common_xls-Supplementary_Table_6_Luminal_Signature_Genes_increased_in_all_four_cell_lines_MCF7_T47D_MB-453_SKBR3_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K44368508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04731
BRD-K98061543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17042
GSE233679_5_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148263_6_v_9_trim3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147366_3_v_0_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
PB-18-HD85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.829308
GSE202434,GSE202438_6_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.321681
GSE89018_1_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.17977
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_3_TurboID_1hr_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
SNU1544	DepMap CRISPR Gene Dependency	1.0	2.4386
GSE202434,GSE202438_2_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Daidzin_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0208109
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2202
GSE138050,GSE148257_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.8871
496100490_HIP_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07754
BRD-K10541973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38045
GSE242367_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2967
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254681
CRCGN011_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1597
GSE142430_3_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10534007-Table_3.xlsx-S4_unique_down_MSC_B-159_elements_included_exclusively_in_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K54628954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28896
GSE233679_12_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10123531-NIHMS1874945-supplement-Table_S3.xlsx-DAY1_SOX17_peaks-Gene_Name_SOX17	Rummagene Transcription Factor Associations 2026	1.0	null
RAB25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46955
GSE192870_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Body wall muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
ED-71-GA72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248009
GSE191174_0_v_1_ccdc92_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.54615
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1155
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
Skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8200296-LSA-2020-00928_TableS2.xlsx-table_s2_DEGs_log2foldchange_0-Table_S2_List_of_DEGs_induced_by_YY1_knockdown_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
ABCA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60304
response to peptide hormone	GO Biological Process Annotations 2025	1.0	null
BRD-K84320538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25959
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-49-NG46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226209
CRCGN015_HEPG2_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.72188
CF-50-QK79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203259
regulation of protein localization to lysosome	GO Biological Process Annotations 2023	1.0	null
Early infantile epileptic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.417
AC-83-LN99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261679
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33068
BRD-K76578941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02329
GSE175787_4_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146626
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7545
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6003
NPAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35045
BA-69-TQ80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232086
A549_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110645
GSE98964_1_v_4_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K71808107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0881
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE241701_2_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K04365932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56816
ferulic-acid	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19543
CRCGN015_HEPG2_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.98801
GSE228619_0_v_1_cdh11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154350_1_v_0_ascl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A94465834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03471
BRD-K03608799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69805
response to amino acid	GO Biological Process Annotations 2023	1.0	null
GSE226355,GSE226357_1_v_0_ybx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01891
PRELID3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6381
BRD-K99034771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9652
BORA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02076
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.6262
Elagolix sodium_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00662806
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.18652
BRD-K31960013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17852
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.527464
CRCGN014_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1568
BRD-A95442017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17722
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.648529
RBIS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1921
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	103.27
GSE229973_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE157904_2_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
IC-18-TY61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217301
BRD-K05535086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07322
Adenocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31924
BRD-K97700172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51244
MD-86-UW46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.395233
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K73650939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51841
CECR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44597
CRCGN012_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55244
ABI3BP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00661938
CRCGN011_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.0487
PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_left-x_TFEB_KO_con_VS_WT_con_DOWN_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE48812_7_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_Jurkat_LPS_vs_DC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Larynx squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.857
BRD-K90003650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53361
GSE114284_4_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_4_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.729917
KB-78-BE93_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.356517
BRD-K82433264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08845
LMX1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.085
BRD-K14602451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35138
Monocyte Count Result	DisGeNET Gene-Phenotype Associations	1.0	null
GC-69-JF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237791
BRD-K64424704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94195
BRD-K81568980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10829
IL12RB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00619862
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K04848570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15102
NOL4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31802
NAXD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1851
PPP2R5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33357
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.6748
GSE216988,GSE216989_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02392
BRD-K10176883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3094
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3858
IRF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6449
lytic vacuole membrane	GO Cellular Component Annotations 2025	1.0	null
KE-37-MN32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259158
CRCGN011_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.30355
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.0783
GSE182854_2_v_3_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193541_0_v_3_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100333_FWM_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.23574
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0906
BRD-K23860926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67831
BRD-K62193937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14757
CRCGN010_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08619
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.5099
GSE135244_0_v_1_trdmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-36-TL21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203799
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.727166
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169356_2_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.17715
496100458_FWM_no dementia_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12044
GSE216273,GSE216292_14_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Msgn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.0424
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.4431
response to organonitrogen compound	GO Biological Process Annotations 2023	1.0	null
GSE192771_2_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
QE-18-WG07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294576
A549_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193438
GSE228181_4_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K70116387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11259
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.73581
AC-30-XU83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2484
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_4_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K17965071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05144
BRD-K67406305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07992
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9135
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.111
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35588
GSE110440_2_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BARX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11806
VASN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43847
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.646877
PMC4219345-1471-2121-14-52-S3.xlsx-BORIS_hNP1-Gene_Symbol_CTCFL	Rummagene Transcription Factor Associations 2026	1.0	null
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.798116
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.368792
Lysosome	KEGG Pathways 2026	1.0	null
SKRC20	DepMap CRISPR Gene Dependency	1.0	6.96875
GSE151782_4_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185139_1_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.35018
BRD-K79232672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43794
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE143944_2_v_3_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.5323
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCallEPC1-PHF1_H3K27me3_k562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K23430426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49005
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.111
ARHGAP33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3018
GSE172016_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VCAP_PROSTATE	CCLE Cell Line Proteomics	1.0	9.10065
Renal tubular acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
CRCGN012_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4354
SNU840	DepMap CRISPR Gene Dependency	1.0	6.29345
GSE176008_8_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lysosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3055
CRCGN015_HEPG2_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.44862
GSE184892_6_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.5923
AD-00-WA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222501
CRCGN015_MCF10A.TP53.M_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67497
PMC11732233-mmc1.pdf-368-ATMIN_ATMIN	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE209898,GSE209899_0_v_1_flcn_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K87812655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11642
GSE121824,GSE121826_0_v_3_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.355267
Carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K93817456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08567
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
FA-06-GA39_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22787
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2107
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.7952
GSE136894_1_v_0_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GD-51-SU60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210142
GSE60691_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ORC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04226
Monocyte Count Procedure	DisGeNET Gene-Phenotype Associations	1.0	null
chr16_84491814_G_C_b38	GTEx eQTL 2025	1.0	1.56018
PMC8298514-41467_2021_24813_MOESM22_ESM.xlsx-ZEB1_H3K27ac-SYMBOL_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63007
AMIGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23853
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.10049
GSE135686_2_v_3_etomoxir_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11643336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11895
GSE233679_12_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_left-y_TFEB_KO_LLOMe_VS_WT_LLOMe_DOWN_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of protein localization to lysosome	GO Biological Process Annotations 2025	1.0	null
BRD-K69087429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1791
DSTYK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08432
A549_Abexinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0103772
CRCGN012_HEPG2_24H:N19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00181
Lytic vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE176008_0_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RNF135	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04252
GSE192870_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lytic vacuole membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K70145120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.77636
CRCGN014_HEPG2_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83279
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202365
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9557
BRD-K30436657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22106
GSE129244_3_v_1_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2639
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352169
PITX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4331
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	70.1176
GSE162892_3_v_0_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.53375
CRCGN014_HEPG2_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.21106
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DCAF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06184
MEGF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61308
D458	DepMap CRISPR Gene Dependency	1.0	2.11708
KASUMI2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.162
LUDLU1_LUNG	CCLE Cell Line Proteomics	1.0	2.0481
GSE233679_12_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE248935_1_v_0_cd14_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nonpigmented ciliary epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.596
496100406_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.33933
NODAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16354
KPNA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41441
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE196671_5_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K01463627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86409
BRD-K60057192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23925
HCT-116 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.83
BRD-K10775155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16004
BRD-K03461876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37172
BRD-K10146653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19328
CRCGN015_HEPG2_48H:I07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22849
Esophageal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.111
PMC4599908-pgen.1005526.s009.xlsx-Table_S8-Overlap_of_FOXO3_direct_targets_from_Eijkelenboom_et_al_with_clusters_R_and_Q_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K91043938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13143
CRCGN014_HEPG2_3H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.01565
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AB-85-JR73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.378614
TMEM234	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9067
EME2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08461
CRCGN016_MCF10A.WT.HP_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10725
MED28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07393
RRP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39063
BRD-K79347939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03684
GSE210101,GSE210114_5_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lopinavir_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0158919
BRD-K97170716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1467
RNF181	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27705
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340865
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2672
BRD-K65314728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91912
CRCGN015_HEPG2_48H:B19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20159
GSE226249_2_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.654792
GSE201381_0_v_1_bhlhe22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NIPAL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16119
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1753
GSE206784_2_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K81952048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13952
Oxoglutarate dehydrogenase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.408
PMC9714459-DataSheet3.xlsx-Supplement_3A-1166_common_elements_in_MSC_and_Fibroblasts_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE179880_10_v_3_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.8767
ANAPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2483
TMEM218	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12262
GSE173873_12_v_13_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_10_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_0_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.50213
UM-SCC-17A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.208
GSE209898,GSE209899_0_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K21051792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1518
BRD-A00680357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85557
Early myoclonic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.245
GSE173873_1_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145476_2_v_3_hopx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NKX2-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3506
SMARCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15185
BRD-K65887908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02937
BRD-K29338816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44966
MA-58-RR04_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270699
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.60949
BRD-K34907403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00021
LLGL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51822
Lytic vacuole membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.405
BRD-K59484021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45142
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K72029544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40632
Cocaine dependence	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.504576
BRD-A73150064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52178
GSE233679_14_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
AB-71-CI37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324432
BRD-K63058274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75131
GSE84922,GSE84924_0_v_3_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.58195
GSE226249_5_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE197555_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GOLGA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51218
BRD-K90519599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21547
GSE129244_3_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K44866331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33063
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.727431
GSE162892_3_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MST1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32746
GSE210101,GSE210114_2_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.657347
lytic vacuole membrane	GO Cellular Component Annotations 2023	1.0	null
BRD-K13330525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08628
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247888
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6979
CRCGN008_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1401
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.590218
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K10017294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22771
CRCGN009_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.127
GSE146982_4_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_proteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223893_1_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.836397
Lysosomal lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.955
BRD-K59134599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79141
BRD-K29642620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12029
GSE221356_1_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S18-Table_S18_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-002_4H_vs_DMSO_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
UM-SCC-17B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.218
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5694
BRD-K45343543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77145
BRD-K39390441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3579
GSE215086_4_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235390_4_v_2_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
PAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06206
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9866
GSE184902_3_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K39271757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.87543
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K19702946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49138
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
lysosome	GO Cellular Component Annotations 2023	1.0	null
THRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.7012
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.382886
CRCGN017_MCF10A.TP53.M_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0504
chr16_84484114_G_A_b38	GTEx eQTL 2025	1.0	1.47843
BRD-K98432726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20824
TNIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45621
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K61078510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12054
CLINDAMYCIN-PO4	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34189
GSE138672_0_v_1_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K44052748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0056
Vacuolar membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208472
Tetracycline (hydrochloride)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0136005
CRCGN015_HEPG2_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.17554
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-encode-consensu_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K19567079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00363
GSE173873_8_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K25702540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11219
GSE89018_11_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K17708304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0569
BRD-U28903152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01044
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE167224,GSE168147_3_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151494_1_v_4_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93752373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11846
CRCGN017_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0366
GSE217452_2_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1102
AA-52-JS03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.584872
GSE164529_0_v_2_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6856_PSMB7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.34688
BRD-K49473928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20231
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE48812_8_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.88653
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.11806
Nucleolus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
ONDA7	DepMap CRISPR Gene Dependency	1.0	2.92082
CRCGN008_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.072
GSE238018_3_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.13472
BRD-K05253426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15692
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246564
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.13271
GF-37-MB64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.403678
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K79521948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69674
GSE184892_4_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KB-78-BE93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.71025
Breast cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00768061
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_4_Overlap_of_ERM_proteom-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K41327620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31
BRD-K13229082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88341
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K81995936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75504
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1525
GSE249098_1_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K90956468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27483
BRD-K77290793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0273
BRD-K04521490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23657
BRD-K69840402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27667
BRD-K62982533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08262
Colon - Transverse	GTEx Tissue Gene Expression Profiles 2023	1.0	4.15027
GSE202434,GSE202438_8_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133182
Cellular metabolism and vesicular transport regulation	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
PMC12211054-spectrum.00100-25-s0002.pdf-79-MAZ_MAZ	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A06840811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08354
GA-47-MH68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.335227
A549_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136811
FUT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00483306
GSE86507,GSE86509_3_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.40125
GSE179002_4_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_3_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-Suppl_Table_6_DEG-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AC-30-XU83_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.3522
NCIH520	DepMap CRISPR Gene Dependency	1.0	3.62489
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.652
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1d-List_of_2302_of_genes_differentially_regulated_by_SOX2_FDR_0_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157282_0_v_3_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sum basophil neutrophil counts	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.10969
GSE226249_5_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.5464
GSE48812_8_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NSC-625987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68235
BRD-K36952018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13241
KD	DepMap CRISPR Gene Dependency	1.0	7.13634
GSE242367_1_v_0_dpp9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Eosinophilia	DisGeNET Gene-Disease Associations	1.0	null
NO10	DepMap CRISPR Gene Dependency	1.0	2.01529
ED-43-XF39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214799
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.52236
GSE142210_11_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A99750020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17631
BRD-M90541854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23842
GSE140074_1_v_0_kif20a_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BD-69-XG81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.448326
HA-32-YH61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.318582
SIAH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00395221
MCF7_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166259
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.92022
SYO1	DepMap CRISPR Gene Dependency	1.0	7.84517
BRD-K37480258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29992
BRD-K18686200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65003
Elagolix sodium_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0097297
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.5895
COLO741_SKIN	CCLE Cell Line Proteomics	1.0	2.81988
LD-69-ZV56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268207
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40427
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K10862230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63918
GSE160817_5_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE244710_1_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LIVF001-008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46713
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.500569
BBL003126	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53224568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21396
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_5_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K28579021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38865
GSE118077_4_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE57871_6_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DLGAP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36625
CRCGN017_MCF10A.WT.HP_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.19855
BRD-K12175788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16727
BRD-K79551673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02004
GSE123943_4_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_3_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7941712-40478_2021_1135_MOESM12_ESM.xlsx-Table_S4D_DEG_ST-EPN-RELA-Unnamed_6_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
NTERA2CLD1	DepMap CRISPR Gene Dependency	1.0	5.39026
VA-48-RJ44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.332447
GSE157594_6_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8522
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324822
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K21969044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00466
GSE201401_2_v_0_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223908,GSE223909_1_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE245270_1_v_0_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.51
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3622
BRD-K07614312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49982
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HD-29-PZ41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215924
RPL39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75388
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-GM12878_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.563284
J82_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	4.12434
BRD-K85292767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2178
BC-54-ON71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.639561
ONDA9	DepMap CRISPR Gene Dependency	1.0	2.11688
Granulocyte count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.15229
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7162
GSE206226_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE215086_3_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal lung morphology	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-A20314546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13793
GSE89018_12_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_2_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24036
BRD-K12035825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2304
BRD-K71824916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16999
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0063
GSE233679_6_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE60691_2_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52491
TE14_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	5.95642
BRD-K73587666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72018
GSE235066_4_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.44807
PMC11282827-40659_2024_524_MOESM5_ESM.xlsx-TAL1-sequence_name_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of cell migration	GO Biological Process Annotations 2023	1.0	null
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23428
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88967
IMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2614
BRD-A30758703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02755
BRD-A99990159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75023
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
response to insulin	GO Biological Process Annotations 2025	1.0	null
BRD-K14019014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10121
AE-32-DP61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.426863
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.97086
GSE201877_1_v_0_yap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157233_2_v_4_a1cf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199255,GSE199356_6_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8367
GSE233679_5_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217552_3_v_5_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nuclear lumen	GO Cellular Component Annotations 2025	1.0	null
MCF7_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150798
AA-88-PJ86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.383715
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.801
PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_12_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-Aza_atRA_DE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K15867859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77114
HSD11B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1716
GSE148200_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of protein localization to lysosome	GO Biological Process Annotations 2023	1.0	null
QB-88-PG52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370365
BRD-K73635724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16686
GSE112860_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8807392-41375_2021_1393_MOESM2_ESM.xlsx-data_integration-YBX1_iCLIP-targets_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE173873_10_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NC-52-AG88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.318995
BICDL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01384
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.625
PMC11336098-41598_2024_70235_MOESM1_ESM.pdf-388-MAF_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
TTC709	DepMap CRISPR Gene Dependency	1.0	3.28096
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.451671
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.113
nucleolus	GO Cellular Component Annotations 2025	1.0	null
OB-17-DQ74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.414977
BRD-K17412949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20813
BRD-K03214579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21319
GSE167373_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158431_5_v_7_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216238,GSE216241_0_v_1_tonsl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Symbol_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
DOORS syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.27
GSE137818_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K68314790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88186
Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.522185
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K64660038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59939
GSE235550_2_v_0_hspa9_human	RummaGEO Gene Perturbation Signatures	1.0	null
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216128
GSE171486_4_v_0_ddx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE163282_12_v_2_aspirin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-18-UF01_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254054
CRCGN015_HEPG2_48H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25902
BRD-K74216068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1572
SBNO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23927
GSE154577_13_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HGF cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.722
BRD-K61681480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.402
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5744
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24684
BRD-K25675728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0952
GSE184902_3_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Epithelioma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC7794364-41540_2020_161_MOESM3_ESM.xlsx-NSP_Unique_-_PPH2_predictions-Gene_Sym_SMAD9	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.03288
BRD-K59437706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07638
GSE109565_12_v_4_glyphosate_human	RummaGEO Drug Perturbation Signatures	1.0	null
BF-89-QD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.378485
GSE176008_4_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE207611,GSE207612_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0106806
GSE151612_4_v_3_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100475_TCx_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06473
TA-19-YA45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258594
GSE137818_3_v_7_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229973_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
C75	DepMap CRISPR Gene Dependency	1.0	2.44538
GSE222758_0_v_2_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF616	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00813
DC-47-KV62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.319488
PMC10534007-Table_3.xlsx-S4_unique_down_MSC_B_2-159_elements_included_exclusively_in_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281925
TB-06-VB30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.23803
AF-00-QK19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231932
MI-3	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K93316985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42678
BRD-K55877261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23706
GSE118766_2_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-13-OQ01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274601
GSE226249_0_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K57969360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46823
BRD-K62541003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03953
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ESS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85242
PMC10274745-media-4.xlsx-S3B-Table_S3_Reanalysis_of_publicly_available_data_to_identify_AR_and_ER_direct_target_genes_related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.6323
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.54242
BRD-K81586131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0521
ID-90-NM43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290778
CRCGN014_HEPG2_3H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00099
PIGQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20072
BRD-K42713448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4418
Sum neutrophil eosinophil counts	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.1301
Hypodermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.914
GSE248045,GSE248046_4_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62418
GSE89018_10_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LMX1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8479
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9253
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.75097
GSE244518,GSE244520_1_v_0_dnmt3b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JHH1_LIVER	CCLE Cell Line Proteomics	1.0	3.58067
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.14805
ENKD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23713
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POU4F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27716
GSE214505_0_v_1_akr1b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3978
POLR3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7035
GSE206784_3_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K60272064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58435
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.372843
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216043_11_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Vacuolar lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.907
GSE215086_5_v_7_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233183,GSE233187_2_v_6_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
GSE223908,GSE223909_4_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
1-EBIO	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27112
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	125.606
CRCGN013_HEPG2_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35827
regulation of cell motility	GO Biological Process Annotations 2023	1.0	null
BRD-K35441510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38084
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE233679_12_v_4_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.532376
AC-36-TL21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202432
BRD-K45893504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24251
Gut microbiota (beta diversity)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.730103
ERGIC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00607
GSE131588,GSE131690_1_v_0_setd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139975_3_v_0_rnf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A46566149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10309
BRD-K75136523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70481
PMC7925689-41467_2021_21687_MOESM10_ESM.xlsx-A_HIF1A-Unnamed_8_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
OLIG2-29049317-MOUSE-SPINALCORD	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.3778
BRD-K89257372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18102
AA-30-BE85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253018
CLC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520746
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2035
GSE146546,GSE146807_0_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4728380-ncomms10153-s11.xlsx-M2069-BILD_MYC_ONCOGENIC_SIGNATURE_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE223540_2_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.548
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35464
PFSK1	DepMap CRISPR Gene Dependency	1.0	4.34778
positive regulation of protein localization	GO Biological Process Annotations 2023	1.0	null
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4293
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
MLYCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06219
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05357297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24334
TAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4095
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.525617
CRCGN012_HEPG2_24H:J21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.53471
AB-97-BI36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29197
IA-76-ZU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205561
BRD-K54922310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86434
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE182680,GSE182683_10_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K87023633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43135
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6802
MAGEL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37526
BC-00-YH62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212832
BRD-K73210450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24605
abnormal epididymis morphology	MGI Mouse Phenotype Associations 2023	1.0	null
MCF7_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00817184
CRCGN015_HEPG2_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.745
GSE139427_2_v_1_ibrutinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K37015376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14526
GSE130956_2_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K94913575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33305
BRD-K92941354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04891
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7013
GSE158975_0_v_1_spp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EWSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0917
TOR signaling	GO Biological Process Annotations 2023	1.0	null
BRD-K75453159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09382
GSE58498,GSE58501_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11772884-41421_2024_747_MOESM6_ESM.xlsx-7_DEGs_USF2-KO_vs_control-Gene_Symbol_USF2	Rummagene Transcription Factor Associations 2026	1.0	null
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04152
BRD-K41031262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45633
GSE217541,GSE217543_3_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-73-BW50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292393
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TGFBR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73864
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235066_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202825_2_v_1_ano1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST12-Unnamed_8_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226249_5_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K98374711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03916
BRD-K77990919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09964
GSE235066_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.06304
A549_IOX2_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158168
GSE175787_11_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K51163606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98621
ZNF93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10664
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K39348592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51131
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K53110645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0619
BRD-K89110518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10392
Zfp809	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.2018
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305748
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77183
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353192
nuclear lumen	GO Cellular Component Annotations 2023	1.0	null
GSE155972_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-93-VT73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.487147
BRD-K68438316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4095
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.29343
CRCGN017_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.90092
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredPeptides-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30921693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34282
regulation of cell migration	GO Biological Process Annotations 2025	1.0	null
GSE199255,GSE199356_3_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.09666
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.413067
GSE171572_3_v_4_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE152734,GSE152735_1_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC2263127-pone.0001816.s001.xls-E2F3_down_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184902_4_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SPAST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03531
BRD-K43205312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09665
GSE195713_0_v_1_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333452
Vacuole	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN014_HEPG2_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0448
BRD-K07755570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47033
BRD-A20305532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70801
BRD-K18828858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09353
Mean corpuscular hemoglobin concentration	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.15229
BRD-K66643401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00539
GSE239844_4_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HAUS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01595
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.790982
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.343466
BRD-K31672963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93725
BRD-K01554997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.471
BRD-K70936779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98439
BRD-K11923178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47607
Neonatal period electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.178
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D3_1784_AR-DEGS-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ST486	DepMap CRISPR Gene Dependency	1.0	2.39323
GSE223540_1_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.906059
RBSN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58449
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Skeletal muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE216273,GSE216292_14_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K14037093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25447
GSE48812_3_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chaperonin-containing T-complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.837
BRD-K79877849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22697
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K27616003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26784
NALOXONAZINE-2HCL	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28353
MMP28	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00631068
A549_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158199
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.75424
BRD-K04810287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57461
Basophil count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0
GSE214931_4_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160817_0_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
AB-30-CR11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.335066
GSE184902_4_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K61873333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16129
GSE215086_1_v_7_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351831
CRCGN014_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.31734
BRD-K41532285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48525
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.27527
SW982	DepMap CRISPR Gene Dependency	1.0	2.23687
Esophagitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.111
GSE215086_8_v_7_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1458
BRD-K99022424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33381
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_2_TurboID_10m_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152441,GSE152442_1_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65658
CRCGN015_HEPG2_48H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03443
S0-EE-Y6WJ_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.456884
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3722
BRD-K36736230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30065
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
GSE181517_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K06208863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00415
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
SLFN12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27805
RNF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57431
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.44496
NKX1-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04622
BRD-K34624391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15903
GSE178532_2_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE248874_1_v_0_pcdh9_human	RummaGEO Gene Perturbation Signatures	1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.65956
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.489246
intracellular non-membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
SUDHL8	DepMap CRISPR Gene Dependency	1.0	2.19088
GSE228017_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	1.0	null
IA-27-CK10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.373002
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
IC-05-AW29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258796
RPL28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13652
GSE160817_4_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-51-FB60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.306034
CRCGN011_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76005
CASP10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00342944
BRD-K20024170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00535
GSE215086_1_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:H13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77689
BRD-K55857083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5124
EIF3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13298
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
White Blood Cell Count Procedure	DisGeNET Gene-Phenotype Associations	1.0	null
GSE202434,GSE202438_12_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60707
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.57222
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE218879_1_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Gingival cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.624
Macular thickness	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.2699
GSE178714_3_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CB-02-XL81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243519
BRD-K90625628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11161
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243222
GSE149035_2_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NDUFA11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16055
PSMG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61419
ZNF821	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28815
BRD-K81385845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46137
PMC7062471-elife-52504-supp6.xlsx-TEAD4_motif_in_OCR_around_DEGs-Gene_ID_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150735
CRCGN015_MCF10A_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1626
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.97989
GSE220097_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K97183783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40902
BRD-K16919185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19499
GSE218060_5_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K84800135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.32287
BRD-K77627909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3588
GSE210377_0_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K23836639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.593
BRD-K87230984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1769
CRCGN015_HEPG2_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.72619
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
BRD-K27754030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14388
NFRKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44868
ASS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1602
GSE111660_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100412_FWM_possible Alzheimer's disease_TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.49688
CRCGN014_HEPG2_3H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4838
GSE148263_6_v_0_trim3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K83721789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05127
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9627
K562_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128114
GSE202434,GSE202438_4_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TOR signaling	GO Biological Process Annotations 2025	1.0	null
PPP2CA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07474
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K46664882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81087
BRD-K68312794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13104
GSE178714_1_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9424213-41467_2022_32537_MOESM5_ESM.xlsx-HeLa_IER3-AS1sh_DEGs-DEGs_in_HeLa_IER3-AS1sh_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186953
GSE118939_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
Mean platelet volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.33979
DCAF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76784
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314407
GSE233679_12_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
lysosomal membrane	GO Cellular Component Annotations 2023	1.0	null
CTCF-33576154-HUMAN-PERIGASTRICLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K79072801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81668
496100586_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.59537
BRD-K93941597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61605
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0569
GSE205556_2_v_0_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_2_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE89018_1_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24566
VD-76-SO91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.388783
Stat5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.0195
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
KYSE30	DepMap CRISPR Gene Dependency	1.0	2.09401
BRD-K27356753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30153
Phagolysosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.898
GATA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1846
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PRKCI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79979
BRD-K39597125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45376
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.63309
A549_Barasertib_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.011517
INTS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.621
BRD-K42804674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61406
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297217
KE37	DepMap CRISPR Gene Dependency	1.0	2.83492
LCLC97TM1	DepMap CRISPR Gene Dependency	1.0	2.21958
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07663
BRD-K98772859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30078
GSE48812_8_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K65506286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0282
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_2_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260554
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.8
GSE191037_0_v_1_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE138938_1_v_3_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4823830-ncomms11171-s4.xlsx-high_in_shRNA_TCF1-GeneSymbol_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE121043_0_v_1_aldh1a1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CC-47-VS90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310302
BRD-K60190533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66834
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253798
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2438
POU3F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61429
GSE226249_0_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10703699-41588_2023_1554_MOESM3_ESM.xlsx-T4B_BATF3_upreg_padj_0_01-Gene_Name_BATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE81796_0_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE161170,GSE161268_0_v_2_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50894381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38788
LRFN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13583
COX19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19147
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCallEPC1-PHF1_H3K27me3_k562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10828394-41698_2024_509_MOESM1_ESM.pdf-115-TFAP2A_TFAP2A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11437185-41467_2024_50986_MOESM4_ESM.xlsx-MECOM-IP-MS-Gene_names_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233426
STK35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25851
Lymphocyte count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	4.52218
BRD-K95672029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07932
CRCGN012_HEPG2_24H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.85345
GSE226249_0_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77795_0_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223609,GSE223610_0_v_1_kdm6a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WDR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05954
CRCGN009_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81826
CRCGN013_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38285
SAR020106	DeepCoverMOA Drug Mechanisms of Action	1.0	0.42
MCF7_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00889277
Eosinophilic esophagitis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.111
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE133927_1_v_3_meox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SKIC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15249
EOL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.60729
GSE48812_3_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138873
GSE160373_8_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143944_2_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE233679_14_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.718
GSE126463_0_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73213
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200751
RUNX1-22343733-PBMC-HUMAN-BONEMARROW	ChEA Transcription Factor Targets 2022	1.0	null
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K90655269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52374
GSE139455_0_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K06356885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01391
Posterior cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.887
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273208
Bhlha15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.8113
lysosomal membrane	GO Cellular Component Annotations 2025	1.0	null
TBCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18651
GSE146982_4_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PITX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6322
GSE207863_0_v_1_hdac5_human	RummaGEO Gene Perturbation Signatures	1.0	null
DB-56-XL71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208344
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1964
SPDYE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11033
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.912013
BD-18-MM33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351035
BRD-K03479638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09004
White blood cell count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	3.6699
BRD-K96652989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36897
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
LIVF001-025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38967
BRD-K70685307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22056
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.650075
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263007
GSE146982_4_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE218727_2_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.111
SET2	DepMap CRISPR Gene Dependency	1.0	4.04637
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.988775
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
Flumatinib (mesylate)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00932204
BRD-K06203932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4693
BRD-K97886487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09594
GSE178714_6_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-63-DM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293689
intracellular membraneless organelle	GO Cellular Component Annotations 2025	1.0	null
JA-85-SW39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296078