association	dataset	threshold value	standardized value
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210101,GSE210114_2_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_6_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PD-50-SI33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29987
A549_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015982
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.9873
BRD-K09903493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32405
Pars compacta	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.942
CRCGN011_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4319
FOXA1-26457646-LHSAR-HUMAN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
CDK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97479
HT1080	DepMap CRISPR Gene Dependency	1.0	2.27748
chr3_197139871_T_C_b38	GTEx eQTL 2025	1.0	1.71315
A549_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01181
BRD-K23232542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.3758
GSE217526_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Neuralgia	DisGeNET Gene-Phenotype Associations	1.0	null
SW1116	DepMap CRISPR Gene Dependency	1.0	2.74049
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K76215709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1056
Midgut epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
MYOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05891
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
CHST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53462
WASHC2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2585
CDX2-21074721-CACO-2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SYT12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27843
PMC8405683-41419_2021_4120_MOESM2_ESM.xlsx-Sheet1-Table_S2_MYCN-responsive_gene_list_1_5_fold_p_0_05_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GATA6-21074721-CACO-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Post-translational protein phosphorylation	Reactome Pathways 2024	1.0	null
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	226.39
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229994
BRD-K80462316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29433
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.924
Amsacrine_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0266318
GSE233679_6_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K03376048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84355
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7857731-elife-63093-supp5.xlsx-ECMdegs-pB-MITF-FLAGvs_pB-FLAG-Unnamed_44_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228616
CRCGN015_MCF10A.WT.HP_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.42722
CRCGN014_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.61054
TPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58246
REV3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21975
BRD-K89376690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16963
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.19
AE-71-CB15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23072
Cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293999
HULC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.957
regulation of extracellular matrix disassembly	GO Biological Process Annotations 2025	1.0	null
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7857731-elife-63093-supp5.xlsx-ECMdegs-pB-MITF-FLAGvs_pB-FLAG-Unnamed_3_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K15373812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37884
NOB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9819
CBX2-22325352-293T-REX-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Neuroectodermal Tumor	DisGeNET Gene-Disease Associations	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2719
Capivasertib_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0209499
PMC9886955-41420_2023_1325_MOESM12_ESM.xlsx-H6_14AvsH6_NC-Unnamed_2_HMX1	Rummagene Transcription Factor Associations 2026	1.0	null
hTERT-HSC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.816
Brain capillary endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.871
PMC10353540-Table_1.xlsx-HCC1954_AR_vs_HCC1954_A-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233303
BRD-K34028745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31617
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO Molecular Function Annotations 2023	1.0	null
Hexylresorcinol_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0250546
BRD-K24479270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1854
ED-71-GA72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299969
PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE238018_3_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_14_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K75746738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00361
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0625
CRCGN017_MCF10A.WT.HP_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3861
A549_Ruxolitinib_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134389
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.0441
MTLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39194
regulation of extracellular matrix disassembly	GO Biological Process Annotations 2023	1.0	null
PLPBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563881
Paricalcitol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.598
BRD-K44236678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13849
AA-52-JS03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222777
Microvessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.29
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D3_1784_AR-DEGS-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211128_9_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K17751525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29941
GSE109140_2_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K89063617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16657
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
CNOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75607
BRD-K44946060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07999
GSE216540_0_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0076
GSE210885_5_v_6_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4595011-pgen.1005555.s001.xlsx-BPTF_DOWN-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K21139023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.53484
BRD-K18573205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80545
Cysteamine (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0315891
CRCGN016_MCF10A.TP53.M_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15606
BRD-K52148119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25302
DDX50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1083
CLSPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45041
A549_Pracinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118035
BRD-K95460104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18087
Melanotic neuroectodermal tumor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.784
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	213.235
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K61439332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17304
BRD-K22293608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17043
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	106.703
A549_Iniparib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159204
BRD-K08142337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27085
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.123
GSE65617_2_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K99416393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16634
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.415954
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211178
DCAF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75133
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE101546_3_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135352_6_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
G06110VR	GlyGen Glycosylated Proteins	1.0	null
BRD-K12119989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16744
GSE76425_0_v_7_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE143944_1_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPMI-7951 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.751
Meloxicam_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0222419
Metabolism of proteins	Reactome Pathways 2024	1.0	null
Oxaprozin_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0317935
CRCGN009_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.9243
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	100.96
BRD-K17570530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25631
Basal plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.837
A549_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156814
BRD-K10761381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60203
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9270251-mmc2.xlsx-4_Filtered_DEGs_Control_vs_KD_3-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145789
DB	DepMap CRISPR Gene Dependency	1.0	5.39298
BRD-K71893034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15025
BRD-K61551681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41311
GSE157050,GSE157051_2_v_9_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
TTC549	DepMap CRISPR Gene Dependency	1.0	4.3822
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K53634892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30186
BRD-K17821077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66542
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	89.359
GSE229070,GSE229071_0_v_2_sotorasib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K06418332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14058
BRD-K83272071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06902
GSE216043_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.5798
GSE218098,GSE218099_1_v_0_tcf19_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K11433244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62988
GSE48812_11_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
transition metal ion transport	GO Biological Process Annotations 2025	1.0	null
iron ion transport	GO Biological Process Annotations 2023	1.0	null
BRD-K60799989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34901
BRD-K11859767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39022
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.32416
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_PFI-1_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0108368
PMC9336541-Table_3.XLSX-C-vs-H6-L_filter_annot-Unnamed_18_HMX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4695334-mmc3.xls-MDA_SMAD3_DNA_Me-Unnamed_2_SMAD3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.381
GSE190316,GSE190324_6_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Abdomen	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	3.775
Glioma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K48129913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67626
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12585103-pbio.3003444.s013.xlsx-List_of_genes_for_GO_analysis-List_of_genes_undergoing_significant_MXE_upon_PRMT5_KD_under_hypoxia_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FOXH1-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE185944_5_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:A09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65275
Osphradium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.857
GSE149621_2_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20039572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61263
BRD-K18368161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03638
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE185519_3_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CFL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56772
BRD-K01225799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1311
GSE218727_2_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PNMA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33087
BRD-K27352194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34843
early endosome	GO Cellular Component Annotations 2023	1.0	null
BRD-K87264606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13733
Eccrine Dermal Cylindroma	DisGeNET Gene-Disease Associations	1.0	null
GSE199899_3_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Pluteus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.013
Bimiralisib_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0224579
CREB1-15753290-HEK293T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UD-07-US73_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200979
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209666
A549_BMS-911543_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184126
ZBTB33	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.844
BRD-K15739647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98074
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158182_4_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_14_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.380437
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Unnamed_1_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K20053005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28398
FDPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57522
BRD-K23112275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02133
PMC12827430-41467_2025_67591_MOESM6_ESM.xlsx-Supplementary_Figure_15l-FOSL2_ChIP_WT-exclusive_genes_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K14255526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15394
GSE249098_1_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	1.0	null
FARSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17614
GSE153871_0_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12062214-41467_2025_59646_MOESM5_ESM.xlsx-HMGA2_activated_repressed-Gene_symbol_HMGA2	Rummagene Transcription Factor Associations 2026	1.0	null
RPE1SS77	DepMap CRISPR Gene Dependency	1.0	2.2083
endoplasmic reticulum lumen	GO Cellular Component Annotations 2025	1.0	null
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.3641
NFYA-21822215-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K19752998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04726
TAF2-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE158182_5_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE222758_0_v_4_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Microvascular endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.426
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE190316,GSE190324_1_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
HSPB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12556
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K29903367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01579
MAF-26560356-CHIP-SEQ-TH1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
4EGI-1_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0136393
PMC8102188-41375_2021_1231_MOESM4_ESM.xlsx-t_som_AA_healthy-Unnamed_7_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10679662-mmc3.xlsx-NC-D5-ZEB2-Mutant-Upregulated-Gene_Symbol_ZEB2	Rummagene Transcription Factor Associations 2026	1.0	null
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	114.205
GSE127970_1_v_3_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE168807_0_v_7_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.53145
BRD-K03916755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08182
Hindgut	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.108
A549_JQ1_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135534
Anethole trithione_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0412835
CRCGN017_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.506
Oxaliplatin_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.031404
CALM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82382
BRD-K96764878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36224
GSE217776,GSE217829_1_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
Penfluridol_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0138576
BRD-K05699155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65317
GSE247084,GSE247087_0_v_1_cdyl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K39460811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50078
BRD-K60052521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07944
Chromosome 3q29 microdeletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.6
BRD-K08759542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10442
GSE197555_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.992
BRD-K47947160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17322
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0586
BRD-K03070790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88658
IL11RA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.52129
GSE232631_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K30581008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39993
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.0913
BRD-K44512951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3389
GSE120612_7_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE214685_0_v_1_nsun2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K28351377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4945
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200352_10_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	101.242
anophthalmia	IMPC Knockout Mouse Phenotypes	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.20228
ANKS1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71352
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE240344_1_v_0_uxs1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE197850_4_v_2_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12529848-12967_2025_7217_MOESM3_ESM.xlsx-Table_S4-Table_S4_Associations_of_genetically_proxied_proteins_with_risk_of_atrial_fibrillation_by_MR-SPI_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169152_3_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K10781609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24456
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	78.222
BRD-K05734090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80954
PMC4590705-13062_2015_86_MOESM1_ESM.xlsx-Gene_A_-_TP53-Unnamed_20_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
AB-71-CI37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289571
PMC12827430-41467_2025_67591_MOESM6_ESM.xlsx-Figure_4f-FOSL2_ChIP_WT-exclusive_genes_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
KYAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9992
NC-01-ET52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241493
GSE131798,GSE131804_5_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344814
ARAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21525
GSE202310_1_v_0_ube3d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-NFIC_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02881560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03168
CCNH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8181
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K08527280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27582
GSE210870_0_v_1_snai1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
T2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.68
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
GSE199543,GSE239447_0_v_4_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UMRC3	DepMap CRISPR Gene Dependency	1.0	4.19019
BRD-K14719962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68407
Mucopolysaccharidosis II	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.299
A549_ITSA-1_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0117468
SMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10205
SCABER	DepMap CRISPR Gene Dependency	1.0	4.02375
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.2978
496100315_TCx_no dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06632
BRD-K40318276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94057
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226584,GSE226589_1_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133213_6_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_PCI-34051_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154
CRCGN016_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3389
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE144796_1_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE48812_4_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167404
GSE153871_0_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RHJT	DepMap CRISPR Gene Dependency	1.0	2.26752
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-SYMBOL_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE219195_0_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
Clonidine (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0280475
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D1_1591_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K14909006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48025
BRD-K75845970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94241
A549_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161513
BRD-K13211285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99094
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.54233
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
PMC6802116-41467_2019_12517_MOESM5_ESM.xlsx-Sheet1-D9_8_GNF2-SERPINB5_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
prenatal lethality prior to heart atrial septation	IMPC Knockout Mouse Phenotypes	1.0	null
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.092
CRCGN010_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19065
CSNK2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46184
BRD-K23836639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10868
GPRASP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99508
DA-10-ZX00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206491
GSE233679_6_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE134375_3_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77108_4_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.565398
BRD-K83715372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00678
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
AARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67603
GSE171837_1_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Allantoin_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0274553
BRD-K07697589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34242
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7207
Skin cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.05
ZNF343	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.9269
Ppara	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.6288
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217452_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
XRN2-22483619-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
KIF23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3024
GA-47-MH68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.553841
Cepharanthine_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0251101
Erlotinib_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0300881
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.9847
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MSTO-211H cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.562
PMC4212256-mmc5.xlsx-FLI1_log2_results-MIR622_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K41875112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45906
OCT4-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
BRD-K08308527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41737
TIMM10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09329
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Osteoclastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.997
GSE123958,GSE123959_0_v_1_mta1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Melanoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.809
NANOG-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	123.39
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Gene_Name_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203696
GSE169205_0_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
igr1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.999
Brain microvessel endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.826
BRD-K48501991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18269
A549_MC1568_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148612
BRD-K60216304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6572
GSE216238,GSE216241_0_v_1_tonsl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K52956006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39401
Tube foot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.561
GSE111035,GSE111040_10_v_9_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of extracellular matrix organization	GO Biological Process Annotations 2025	1.0	null
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.8792
BRD-K10180613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06222
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredProteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Abexinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114483
CRCGN016_MCF10A.TP53.M_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.05212
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.9645
GSE70935_3_v_5_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9733061-13059_2022_2800_MOESM5_ESM.xlsx-Table_S4-Table_S4_Genes_assigned_to_JUNB_binding_sites_Each_peak_was_assigned_to_the_nearest_TSS_JUNB	Rummagene Transcription Factor Associations 2026	1.0	null
MRPL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54822
CHEMBL2172374	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
BRD-K19227646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77257
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.9016
GSE239688_2_v_5_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZC3H10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76665
BRD-K71870778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00231
GSE147626_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
DYNLRB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03039
RPP38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47311
Dapagliflozin ((2S)-1,2-propanediol, hydrate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.016568
BRD-K04143388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70654
Extracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
abnormal embryo size	IMPC Knockout Mouse Phenotypes	1.0	null
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S18-Table_S18_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-002_4H_vs_DMSO_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K07020302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06521
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.556
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
KLF4-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE135030_11_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.574
BRD-K70923850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1175
Leptomeninx	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.053
T3M4	DepMap CRISPR Gene Dependency	1.0	4.28653
Musculoskeletal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-E2F1_UP_V1_UP-Gene_name_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
Paclitaxel_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0255386
BRD-K25127909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1362
GSE240027,GSE240030_5_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Meprednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165132
GSE213588_9_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
GTF3C2-35216376-H9-HUMAN-BONEMARROW-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
AR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41344
DNA-binding transcription activator activity, RNA polymerase II-specific	GO Molecular Function Annotations 2023	1.0	null
GSE211128_7_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111035,GSE111040_8_v_9_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214931_4_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
GSE230573_1_v_0_dcaf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Epirubicin (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0147227
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:J06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0064
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K68540120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1959
decreased circulating glucose level	IMPC Knockout Mouse Phenotypes	1.0	null
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.295
Arid5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.0782
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6301
SCCOHT1	DepMap CRISPR Gene Dependency	1.0	4.08848
BRD-K61807670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31874
GSE236502_2_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SIPA1L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24389
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.0412
BRD-K09206831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07751
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4119
CRCGN008_HEPG2_24H:D12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1206
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.156
A549_MC1568_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151986
GSE184902_4_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203308_1_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
positive regulation of protein processing	GO Biological Process Annotations 2025	1.0	null
BRD-K18462967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15537
WDR90	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.54736
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
INTS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07323
GSE213588_10_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE206516,GSE206518_5_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
NB10	DepMap CRISPR Gene Dependency	1.0	2.04882
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.48866
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K38350115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24343
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06115
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
A549_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164772
CRCGN017_MCF10A.WT.HP_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78215
PMC10794847-mmc2.xlsx-PBRM1_KD_up-Table_S1_Differentially_expressed_genes_with_PBRM1_knockdown_in_the_progenitor_state_Related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220639
Lopinavir_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0149649
C6 glioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.997
Roberts-Sc Phocomelia Syndrome	DisGeNET Gene-Disease Associations	1.0	null
22RV1_PROSTATE	CCLE Cell Line Proteomics	1.0	2.74946
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ISOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08151
WAOSEL	DepMap CRISPR Gene Dependency	1.0	2.71434
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
FE-64-KC49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.50616
BRD-K07414059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06242
P300-27058665-CHIP-SEQ-ZR-75-30CELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN014_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.87
GSE160373_1_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17555
PMC9714459-DataSheet3.xlsx-Supplement_3A-1037_elements_included_exclusively_in_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
DKC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.59476
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9288
positive regulation of plasminogen activation	GO Biological Process Annotations 2023	1.0	null
BRD-K01960204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78886
Gut	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.022
PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233679_12_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
WHAMM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01211
BRD-K13526697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10669
BRD-K60517939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01106
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Pneo-r__CIC-1n_h-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K15714771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84683
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE109285_5_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE152441,GSE152442_1_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.774
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-eTable_38_Cis-instrument_Mendelian_randomizaion_screen_of_1_901_cortical_proteins_on_lifetime_smoking_behavior_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111035,GSE111040_8_v_12_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.26451
GSE210870_0_v_2_snai1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K05802716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38994
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.2457
GSE228261_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K06743908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65834
Osteoblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.559
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
UBF1/2-26484160-CHIP-SEQ-HMECS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Tadalafil_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0300588
ZDHHC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10048
GSE215086_3_v_7_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213650_3_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8481886-Table_1.xlsx-A_subsets-iMSC_fetal_MSC_UC_MSC_bone_marrow_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
PHF8-20622853-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
WBP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36262
Bosentan (hydrate)_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0331583
GSE188721_3_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
SVIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36688
MED27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70863
Cytarabine (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0259158
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.965
PMC10353540-Table_1.xlsx-HCC1954_AR_vs_HCC1954_A-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K74963702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00423
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
FOXO3-22982991-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE216540_1_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217201_1_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
Neurodegeneration with brain iron accumulation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
GSE225735_1_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ink sac	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.016
BRD-K87669982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30595
GSE203308_15_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3987
GSE226397_0_v_1_cystine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE134375_3_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K36393312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23872
AD-06-OB47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290281
nucleus	GO Cellular Component Annotations 2023	1.0	null
CREB1-26743006-CHIP-SEQ-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
iron ion binding	GO Molecular Function Annotations 2023	1.0	null
PMC8635809-Table_2.xls-LPS-downregulated-Unnamed_4_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
negative regulation of cell-substrate adhesion	GO Biological Process Annotations 2025	1.0	null
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112202_5_v_2_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206516,GSE206518_0_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75675
Insulin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.743
BRD-K43341819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28364
GSE217363_4_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ascidian	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.122
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN014_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15813
BRD-K62229896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17439
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.0384
early endosome	GO Cellular Component Annotations 2025	1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.824869
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
TEAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01172
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9314343-41467_2022_31892_MOESM8_ESM.xlsx-Fig7e-CTCF_in_promoter_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
CPD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43178
Rimonabant_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.041232
BRD-K59049340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30568
OVCA420	DepMap CRISPR Gene Dependency	1.0	3.31897
BRD-K79318959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44717
A549_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173696
Hoxa11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.8042
SMAD3-22036565-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K55766625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40443
CTBP2-25329375-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
regulation of cell growth	GO Biological Process Annotations 2025	1.0	null
CRCGN014_HEPG2_3H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7752
GSE158182_3_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
N4BP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33986
MAF-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Everolimus_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0243266
BRD-K40474424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44328
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
Childhood Osteosarcoma	DisGeNET Gene-Disease Associations	1.0	null
CRCGN015_MCF10A.WT.HP_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.33298
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_Jurkat_LPS_vs_DC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G4_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04163641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01119
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56945
Wing disc	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.842
PMC12331601-Table2.xlsx-KD_vs_CON-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE209598_1_v_2_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A79097167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27425
BRD-K65887908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00051
BRD-K83673542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25941
GSE214931_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239844_1_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXH1-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HNRNPUL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99017
GSE200839,GSE233826_3_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K07274638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85083
CNOT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3321
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158431_5_v_7_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.622
GSE181003_3_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
Human brain microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.512
Buccal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.269
PIWIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17798
SKM-1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.612
BICR22	DepMap CRISPR Gene Dependency	1.0	4.54942
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	108.075
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Olanzapine_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0342764
CRCGN016_MCF10A.TP53.M_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01352
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MOSMO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05864
NB5	DepMap CRISPR Gene Dependency	1.0	3.1041
BRD-K18087940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21764
PMC4686761-ncomms10068-s3.xlsx-S2E-MSC_up_specific-Supplementary_Data_2E_-_expression_of_up-regulated_genes_2_fold_change_specifically_in_MSC_PTEN-_-_vs_MSC_PTEN_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K17852428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9988
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.122
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.475
UTX-26944678-CHIP-SEQ-JUKART-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
A549_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217116
Ciclopirox_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0306657
PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K23553911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12802
increased circulating potassium level	IMPC Knockout Mouse Phenotypes	1.0	null
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-ID_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K21986392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96832
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9426
CRCGN016_MCF10A.TP53.M_24H:M12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89396
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K04834648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31754
GSE149880_2_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cysteamine (hydrochloride)_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0243125
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25914
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.156
BRD-K40189164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03485
BRD-K24514314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47747
BRD-K03093950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.42735
Tofacitinib (citrate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0313957
PMC8948659-ADVS-9-2104491-s013.xlsx-Sheet1-Supplemental_Table_9_related_to_Figure_7_Differential_genes_highly_correlated_with_TP53_deletion_in_H929_cells_by_RNA-seq_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE231720,GSE231724_3_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal retina morphology	IMPC Knockout Mouse Phenotypes	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.7797
BRD-K41538715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38556
Osteosarcoma	DisGeNET Gene-Disease Associations	1.0	null
PMC3253802-pone.0029922.s001.pdf-96-ZFP90_ZFP90	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K95822658	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27875
BRD-K05350978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33889
PMC10773028-40364_2023_552_MOESM1_ESM.xlsx-Variants_sheet-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283675
MEL290	DepMap CRISPR Gene Dependency	1.0	2.98877
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93496326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79109
GSE178340_1_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE129389_0_v_3_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE247764_3_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Mocetinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135056
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12183081-41388_2025_3375_MOESM8_ESM.xlsx-Sheet1-Table_S7_List_of_differentially_alternative_splicing_genes_in_osteosarcoma_cell_lines_after_knocking_down_the_YBX1_gene_P_0_05_Related_to_Fig_6C_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155985
RPS4Y1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40822
PMC8582123-13073_2021_996_MOESM3_ESM.xlsx-PITX1-HIT_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
WM-115 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
PDCD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.36824
Skin mucus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.097
GSE233679_14_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SOCS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03036
Brain endothelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.509
Sapanisertib_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0169645
A549_Dacinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121099
RNF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36458
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE166920_6_v_3_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.32408
regulation of transcription by RNA polymerase II	GO Biological Process Annotations 2023	1.0	null
BRD-K66865641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75872
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.639
Lapatinib ditosylate_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0210302
EIF2AK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43347
Gallic acid_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0273722
EIF4G1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44754
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.526
GSE125403_7_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE125403_3_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bone marrow stromal stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.712
GSE233679_14_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.5387
A549_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.021536
GSE220520_6_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A-2058 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.877
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175699
CRCGN017_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29327
BRD-K65813214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46655
GSE207302,GSE207303_0_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-A16760970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55781
VCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5716
GSE232631_4_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291794
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.286
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.4303
GSE158431_5_v_1_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
crizotinib_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0218061
GSE215086_8_v_7_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241712
Polycystic Ovary Syndrome	DisGeNET Gene-Disease Associations	1.0	null
BRD-K63058274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02513
GSE213228_4_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TSC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50403
PMC9822887-41598_2022_27261_MOESM10_ESM.xlsx-HCT116_overlap_TCF7L2_CTNNB1_lo-Unnamed_1_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
ARMCX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08644
BRD-K72125659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03183
GSE147626_2_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE136742,GSE136744_0_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178907_4_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE250560_1_v_0_foxo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Mocetinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115473
GSE239844_8_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.377
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K36021765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26859
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225692
GSE184902_4_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cervix Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
FN3KRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43573
DHX33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04194
GSE158834_0_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of cellular component organization	GO Biological Process Annotations 2025	1.0	null
BRD-K14970242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87541
A549_Ofloxacin_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155525
Arachnoid mater	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.078
A549_PHA-680632_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.01039
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	98.6434
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	78.268
GSE186633_1_v_0_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.5188
GSE233679_5_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE132694,GSE132717_0_v_2_meis1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pentoxifylline_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0181202
Metal metabolism disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K51956957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31261
PMC11551338-pnas.2411189121.sd01.xlsx-VDR-Unnamed_0_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
PCDHB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91975
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.236
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
regulation of substrate adhesion-dependent cell spreading	GO Biological Process Annotations 2023	1.0	null
BRD-K55742134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20723
GSE213588_10_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.469
Thymol_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0204048
GSE216043_7_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K86966177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26536
BRD-K14671808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05619
ELK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50519
RBMX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.45078
NANOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65278
BRD-K06344882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50422
GSE110268_0_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ornidazole_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0111754
Pyruvate kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.804
GSE179036_1_v_0_trim24_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE231720,GSE231724_2_v_1_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200839,GSE233826_3_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
Globus pallidus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.17
SNU13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8138
PMC11383936-41598_2024_71738_MOESM6_ESM.xlsx-DEPs_LMS_vs_LMS_-_vs_HC-Unnamed_4_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.3073
GSE149359_2_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SFPI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE179880_4_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-D-Enh_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205231
GSE129241_1_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
DNA binding	GO Molecular Function Annotations 2023	1.0	null
GSE233647_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE228125_2_v_1_ptafr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of extracellular matrix disassembly	GO Biological Process Annotations 2023	1.0	null
AA-52-JS03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22937
CRCGN015_MCF10A.WT.HP_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.10167
BRD-K55946794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00991
PMC9314343-41467_2022_31892_MOESM8_ESM.xlsx-FigS7d-CTCF_in_promoter_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83849
GSE205687_1_v_0_mta1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K05799189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0739
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11504463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.35028
Darinaparsin_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0251381
GSE233679_12_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K14193598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74293
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Hesperadin_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.010899
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265014
Ferritin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.998
A549_Quercetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189088
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-TFAP4_TFAP4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE229973_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_AG-490_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159108
KCNC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08389
GSE232786_1_v_0_otud1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
Esmolol (hydrochloride)_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0208802
CREB1-26743006-CHIP-SEQ-LNCAP-ABL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN014_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.36514
GSE223908,GSE223909_1_v_3_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE121198,GSE129782_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_6_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Citalopram (hydrobromide)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0284163
response to metal ion	GO Biological Process Annotations 2023	1.0	null
Anchored component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.882
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
Gill arch	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.632
TMEM191B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51007
GSE202825_2_v_1_ano1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.156
SUDHL8	DepMap CRISPR Gene Dependency	1.0	3.96019
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
CRCGN017_MCF10A.TP53.M_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13087
ETV2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18918
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.713
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.337
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.7615
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Choroid plexus epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.13
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF-21964334-BJAB-B-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
A549_GSK-LSD1 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152214
PMC11067031-pnas.2317690121.sd05.xlsx-Sheet1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K07035171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60596
GSE264010_0_v_1_parp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K62202988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20459
regulation of DNA-templated transcription	GO Biological Process Annotations 2023	1.0	null
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
GSE133516_0_v_6_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
transition metal ion transport	GO Biological Process Annotations 2023	1.0	null
PMC10243915-uxad037_suppl_supplementary_table_s1b-table_s3b.pdf-199-BARX2_BARX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11473359-44161_2024_545_MOESM2_ESM.xlsx-Table_10-Table_10_The_association_of_genetically_predicted_levels_of_proteins_with_the_risk_of_stroke_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cardiac stomach	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.57
SMC4-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HI-TOPK-032_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0279543
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
GSE228106_3_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ranolazine_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0211304
PMC10534007-Table_2.xlsx-S3_unique_up_MSC_V-817_elements_included_exclusively_in_VM-CUB1_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K53770426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46729
PMC10933424-41420_2024_1903_MOESM1_ESM.pdf-277-ZNF256_ZNF256	Rummagene Transcription Factor Associations 2026	1.0	null
HCC70	DepMap CRISPR Gene Dependency	1.0	5.05046
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.472
CRCGN015_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3391
Tentacle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.726
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Coelomic fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.359
light-harvesting complex, core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.735
BRD-K49573242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20496
iron ion binding	GO Molecular Function Annotations 2025	1.0	null
BRD-K62983405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23928
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.416
496100605_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02736
GSE201217_2_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
crizotinib_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0183147
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.499
Oleic acid_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0164282
Sapanisertib_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0187401
GSE145323,GSE145324_9_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169205_0_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171572_5_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Melanoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.054
GSE213588_10_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
B875 antenna complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.735
ZNF224	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07031
BRD-K26994486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14498
BRD-K43896262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0763
GSE154577_2_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133516_5_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.00089
PMC10769395-media-2.xlsx-S2D_EF_Repressed_genes-Ebegboni_et_al_Supplemental_Table_S2D_Increased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
E2F1-26619117-HEPATOCYTES-MOUSE-LIVER	ChEA Transcription Factor Targets 2022	1.0	null
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7209
BRD-K05002317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10756
GSE149901_3_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lapatinib ditosylate_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.033223
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Senile Plaques	DisGeNET Gene-Disease Associations	1.0	null
transition metal ion binding	GO Molecular Function Annotations 2023	1.0	null
VAMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00671
A549_Decitabine_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193989
BRD-K20028052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40642
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	188.416
A549_Entinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147916
CPSF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92679
Malignant Tumor Of Cervix	DisGeNET Gene-Disease Associations	1.0	null
TMEM81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32842
Vascular endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.416
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K72934808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03762
Brain cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.725
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
GSE163862_0_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Sorafenib Tosylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122312
GSE165647_2_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K04143779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54276
GSE111035,GSE111040_8_v_5_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K03512847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56173
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.335807
BRD-K31884664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10553
BRD-K21620541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21218
BRD-K58971526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28071
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
OLIG2-29049317-MOUSE-SPINALCORD	ChEA Transcription Factor Targets 2022	1.0	null
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193177_1_v_0_st266_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_8_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE185519_1_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SUPT6H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.29732
CRCGN012_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5159
BRD-K89336453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37798
BRD-K94452277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63193
KLF5-25053715-YYC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE202434,GSE202438_9_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ralimetinib dimesylate_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0173104
GSE95302_1_v_4_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.644
A549_JQ1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174604
GSE236437_2_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC2263127-pone.0001816.s001.xls-E2F3_down_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
BCL6-25482012-CML-JURL-MK1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE135030_11_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K37975989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54584
GSE178340_7_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZFP36L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55757
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-NFE2L2_V2-Ensemble_gene_ID_NFE2L2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K35588268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6734
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
Photophore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.284
PMC4821877-ncomms10846-s9.xlsx-THP1_Splice_events-Gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11383936-41598_2024_71738_MOESM6_ESM.xlsx-DEPs_LMS_-_vs_HC-Unnamed_4_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
EBC1	DepMap CRISPR Gene Dependency	1.0	4.07932
Temsirolimus_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0233893
Chorioallantois	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.74
Extracellular exosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Vandetanib_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0134558
PMC3930188-813067.f1.pdf-86-MECP2_MECP2	Rummagene Transcription Factor Associations 2026	1.0	null
KDM2B-26808549-CHIP-SEQ-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC11195603-jamapsychiatry-e241429-s002.xlsx-eT38_Protein_cis-instrument_MR-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Piroxicam_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0210658
increased circulating aspartate transaminase level	IMPC Knockout Mouse Phenotypes	1.0	null
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165647_5_v_3_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220196
GSE186647,GSE217288_11_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146074_9_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50272743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14132
GSE215086_4_v_7_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE163862_2_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K90004516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47092
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
MDAMB453	DepMap CRISPR Gene Dependency	1.0	4.72893
BRD-K39692099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28341
GSE233679_5_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K85546819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36
BRD-K19968781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59681
A549_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181736
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE130081,GSE130082_0_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140322_3_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K93875187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37877
BRD-K37486644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08984
RUNX1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K40548004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59219
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOSL1-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
GSE227592_13_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Almonertinib (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0430266
Sima	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.754
BRD-K59046641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03983
sequence-specific DNA binding	GO Molecular Function Annotations 2023	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE133516_0_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PKM2 pyruvate kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.948
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.627
PMC11748740-41598_2025_85338_MOESM1_ESM.xlsx-Table_S2-Table_S2_The_cis-pQTLs_Pass_Instrumental_Variable_Selection_Test_for_Primary_MR_Analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE215086_8_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cobimetinib_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0318464
HOOK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75504
Oleic acid_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0198616
PMC12205070-41467_2025_61222_MOESM5_ESM.xlsx-DE_markers_TAL1_scenic_reductio-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE129241_3_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:F09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48141
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.671818
BRD-K13146924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36674
Sapanisertib_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0270122
BRD-K04399953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23549
BRD-K67817697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89724
GSE126463_1_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ACSL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18854
BRD-K31778735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20119
RBBP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22596
TULP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10699
JUND	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32493
OC-10-FB51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267625
GSE140936,GSE140938_2_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K57155690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04837
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11950375-41598_2025_94053_MOESM1_ESM.xlsx-S25-Table_S25_Results_of_Bayesian_colocalization_analysis_of_MR_positive_proteins_in_plasma_proteins_and_multiple_sclerosis-related_arthritis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE128688_0_v_1_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11582803-41598_2024_80483_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_MR_analysis_of_Proteome_wide_Mendelian_Randomization_FinnGen_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8851354-Table_5.xlsx-Ruxolitinib_reg_FD-bound-Supplementary_Table_5_Genes_regulated_by_ruxolitinib_that_are_FUS-DDIT3_targets_in_MLS_402-91_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K08262651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50021
TAL1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
GSE182680,GSE182683_10_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K84062787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36595
MSC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.058
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.24
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11653668-ADVS-11-2400133-s002.pdf-8-TEF_TEF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K97276563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5494
GSE204811,GSE204813_1_v_3_trim29_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lipoic acid_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0156424
BRD-K39223744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27787
MERO41	DepMap CRISPR Gene Dependency	1.0	3.28243
BRD-K18519876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30223
BRD-K09689420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0243
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K87879912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01345
GSE110580_1_v_0_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K08043579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91778
PCGF4-22325352-293T-REX-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE210101,GSE210114_5_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cargo receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.388
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
CETN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35424
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36862
Angiomyolipoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K17609687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48907
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-51-FB60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255675
Macitentan_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0080718
GATA1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69776
BRD-K09261031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1586
GSE163862_1_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skin	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.234
GSE202434,GSE202438_9_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of cell-substrate adhesion	GO Biological Process Annotations 2023	1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.535102
Cloxacillin (sodium)_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0270776
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.364
KDM6A-18722178-U937-AND-SAOS2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Amyloid plaque	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.308
GSE111035,GSE111040_10_v_12_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K21466747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38705
A549_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016749
GSE209601_0_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K97576000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50711
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Abexinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116502
CRCGN014_HEPG2_24H:A10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24865
PMC7857731-elife-63093-supp5.xlsx-ECMdegs-pB-MITF-FLAGvs_pB-FLAG-Unnamed_4_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GNB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45249
GSE175787_8_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178532_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K12223973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44931
ITGA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34836
PMC12141477-41467_2025_60329_MOESM3_ESM.xlsx-log2FC_0_5_cut_off_-_258_genes-Supplementary_Data_1_Genes_identified_by_both_HLF_overexpression_OE_and_knockout_KO_RNAseq_HLF	Rummagene Transcription Factor Associations 2026	1.0	null
UBL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37903
Hemolymph	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.094
MG-63 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.869
ACTL6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30013
BRD-K79213964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01041
GSE113734_3_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K16626032	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15575
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Reactome Pathways 2024	1.0	null
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Choroid plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.488
low-density lipoprotein receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.446
GSE200352_11_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredPeptides-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251335
NUP58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07763
GSE211128_7_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.9
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Malaria	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.509691
SLC25A27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22224
GSE231720,GSE231724_2_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_3_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RELB-30642670-CTB1-HUMAN-PLACENTA-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233679_6_v_11_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ascites	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	3.775
JVM3	DepMap CRISPR Gene Dependency	1.0	3.22017
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
furafylline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38698
BRD-K94445007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19112
BRD-K54351101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68258
positive regulation of DNA-templated transcription	GO Biological Process Annotations 2023	1.0	null
PMC5918774-13287_2018_864_MOESM2_ESM.xls-sheet-hREPC_AND_AF_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K24502602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02794
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARHGAP11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22013
Docetaxel_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0311386
CRCGN015_MCF10A.TP53.M_24H:J06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15529
A549_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171723
GSE234637_1_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-93-QD45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240201
RBM28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.44253
TAF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03541
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	3.6486
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0286
NEUROD2-26341353-CORTEX-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K30361950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44304
GSE233679_12_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE118532_0_v_1_rnf168_human	RummaGEO Gene Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE152441,GSE152442_1_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GPATCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62383
central nervous system development	GO Biological Process Annotations 2023	1.0	null
BRD-K52152765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00494
PMC10510228-13287_2023_3481_MOESM7_ESM.xlsx-DEGs-Differentially_expressed_genes_DEGs_in_bone_marrow-derived_MSCs_from_six_human_donors_cultured_at_high_confluency_MSC-HC_versus_low_confluency_MSC-LC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12247205-13046_2025_3465_MOESM1_ESM.xlsx-Table_S4-Table_S4_Upregulated_genes_between_patients_with_high_and_low_ASH1L-AS1_expression_ASH1L	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K17536501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54307
GSE195568_3_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233112_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
negative regulation of substrate adhesion-dependent cell spreading	GO Biological Process Annotations 2023	1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
SMC3-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE160373_6_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193993_4_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE200352_10_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.306
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.38619
A549_PHA-680632_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125322
CRCGN017_MCF10A.WT.HP_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32675
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
Docetaxel_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0317384
GSE233679_5_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
HC-01-FD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.457255
Night sleep phenotypes	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.504576
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARPE-19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.564
BRD-K12909905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12551
BRD-K80535598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26023
GSE110268_2_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HSPA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32775
GSE160373_5_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239844_11_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.633
CRCGN015_MCF10A.WT.HP_24H:M18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01692
GSE223908,GSE223909_1_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBL1-22424771-293T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.82864
PMC12164972-FSB2-39-e70689-s001.pdf-52-ZFP82_ZFP82	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K10232513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3156
A549_AC480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228661
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193993_1_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K42757676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12517
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	137.813
Sebaceous gland disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.156
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
JARID1A-20064375-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MM253	DepMap CRISPR Gene Dependency	1.0	4.62291
VDR-24763502-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K61595867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20941
BRD-K57357304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59126
MED7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02392
CRCGN014_HEPG2_24H:A06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02159
GSE101336_1_v_3_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11237048-41598_2024_64364_MOESM1_ESM.pdf-29-ENSG00000136367_ZFHX2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10773028-40364_2023_552_MOESM2_ESM.xlsx-Variants_sheet-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K07557785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26734
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.6743
VDR-21846776-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K32370845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61687
colo853	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.668
GRPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15235
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NDUFB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06504
recycling endosome	GO Cellular Component Annotations 2023	1.0	null
GSE245778_1_v_0_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE129241_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Goserelin (acetate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0193255
Dabrafenib_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0311728
Futibatinib_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00917845
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02947
BRD-K61691014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72205
GSE206516,GSE206518_3_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211128_2_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7459
BRD-K71486446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04833
COPB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59555
GSE227592_10_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K40612106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46902
BRD-K85232515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10137
PMC9038526-mmc1.xlsx-healthy_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Malpighian tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.107
positive regulation of protein processing	GO Biological Process Annotations 2023	1.0	null
CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K04706894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11655
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_Jurkat_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K91361836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79152
A549_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019711
BRD-K95410891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90026
GSE204929_0_v_1_ywhag_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73681382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14241
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K21996189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0813
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Isocorydine_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0456387
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245305
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
Efflux pump complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.326
GSE219195_4_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Mocetinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147284
TTC39C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18493
GSE181513_0_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.378
BRD-K69918256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68955
Adenosine_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0377145
Colon - Transverse	GTEx Tissue Gene Expression Profiles 2023	1.0	2.64792
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00313
RAB11FIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.433
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304027
GSE158502,GSE158506_3_v_0_fat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Skin cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.372
PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.563
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6086
GSE162276_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of extracellular matrix disassembly	GO Biological Process Annotations 2025	1.0	null
QE-18-WG07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234399
NMU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35748
Cervical Cancer	DisGeNET Gene-Disease Associations	1.0	null
TBX2-33478486-IMR90-HUMAN-LUNG	ChEA Transcription Factor Targets 2022	1.0	null
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11409756-13062_2024_533_MOESM1_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_DEGs_regulated_by_ZFP64_through_mRNA-seq_ZFP64	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE247764_0_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02251
transcription cis-regulatory region binding	GO Molecular Function Annotations 2023	1.0	null
Celecoxib_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0182944
CRCGN012_HEPG2_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09068
CTCF-33576154-HUMAN-PERIGASTRICLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K87658102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04313
GSE125014_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Catecholaminergic neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.628
BRD-K61432982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40018
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
SK-MEL cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.981
A549_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011985
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K85627183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08731
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K47370004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37221
PMC4595011-pgen.1005555.s001.xlsx-BPTF_DOWN-regulated-Gene_name_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K19575490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11519
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
METTL27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.07377
GSE77108_8_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182849
GSTCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55895
blood-brain barrier	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.624
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K47212522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78871
PMC12205070-41467_2025_61222_MOESM5_ESM.xlsx-DE_markers_TAL1_scenic_reductio-gene_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
TCF3-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE227592_5_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-E2F1_UP_V1_UP-Ensemble_gene_ID_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169152_3_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Nintedanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0245482
A549_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143135
R3HDM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37196
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K94913508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15394
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.426074
GSE135030_3_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JUN-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
RPS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02832
Tolcapone_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0502961
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF646	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27165
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CB-02-XL81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262451
ENDOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2317
GSE217115_3_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K15800236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05922
RNA polymerase II transcription regulatory region sequence-specific DNA binding	GO Molecular Function Annotations 2023	1.0	null
BRD-K15833017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35342
SULT1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02411
BRD-K04087396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39085
Verapamil_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0311383
LIVF001-019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25026
Baicalin_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0271453
Riluzole hydrochloride_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0340154
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.538
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.332585
PGLYRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02058
YC-57-OY42_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256884
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171177,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE131649_4_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cerebrovascular endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.665
SPI1-23127762-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K57274378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16896
CCDC107	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25803
AA-23-FM46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.491939
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.5038
GSE184892_0_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.7259
CRCGN016_MCF10A.WT.HP_24H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15835
GTF2E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60456
Chloroplast large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.258
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11531655-MCO2-5-e754-s001.docx-0-IRF7_Regulon_4_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.4446
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE129389_0_v_7_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RH30	DepMap CRISPR Gene Dependency	1.0	4.28442
PMC12021535-CPH4-15-e70011-s001.xlsx-S21-KLF2_KLF2	Rummagene Transcription Factor Associations 2026	1.0	null
Renal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.228
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.404934
Ethmoid bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.731
BRD-K44307624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1849
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8568
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25684
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Endosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.9191
CRCGN016_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28389
ASH2L-23239880-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K87161673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58691
PMC4219345-1471-2121-14-52-S3.xlsx-BORIS_hNP1-Gene_Symbol_CTCFL	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K35171408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55688
BRD-K32511780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59788
GSE190316,GSE190324_10_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141598
PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
A549_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206315
GSE135030_3_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EX229_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0192573
BRD-K41888813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12739
Anterior midgut	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.509
BRD-K15928912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01017
Recycling endosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
GSE199541_2_v_5_mbd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93396907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29788
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Metastatic Melanoma	DisGeNET Gene-Disease Associations	1.0	null
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
BRD-K87670244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83606
GSE77108_0_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145105
Midgut	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.156
MIGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04444
BRD-K07602825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24853
GSE128730_7_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K74251295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73708
FNDC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03672
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ATDC-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.686
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.682211
Smooth septate junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.892
JB-28-VO37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233733
Neuroepithelioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.669
A549_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152048
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165307_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229973_4_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.591
GSE118816_2_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6238
BRD-K00231307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18451
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9464
GSE163240_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171543
PMC12422825-aging-17-8-206293-s003.xlsx-i_MR_IP-Unnamed_5_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of cell growth	GO Biological Process Annotations 2023	1.0	null
PMC4531812-13058_2015_618_MOESM11_ESM.xlsx-TCGA_Sparse_KM-TFAP2B_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
Melanosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.582
SAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25489
Yolk	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.037
GSE158182_3_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC78	DepMap CRISPR Gene Dependency	1.0	4.43901
GSE151090_0_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU2535	DepMap CRISPR Gene Dependency	1.0	3.62275
Olfactory nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.563
BRD-K71533707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04599
GABP-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
A549_Alisertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144807
HARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25295
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.9283
GSE233679_12_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE172016_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7617064-EMS151900-supplement-Figure_7_Source_Data.xlsx-HLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
H2AC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29913
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278199
Pleated septate junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.722
BRD-K06537903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86647
GSE158182_5_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE138633_2_v_0_bag3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OV56_OVARY	CCLE Cell Line Proteomics	1.0	5.60818
GATA3-24758297-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
U-87MG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.254
Meloxicam_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0155982
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.84034
Intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Belumosudil_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0222216
BRD-K47707657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36189
SIN3B-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE146074_0_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Valdecoxib_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0270974
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	136.545
Cribriform plate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.747
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC13127299-mmc2.xlsx-PBX1_kdRNAseq-hgnc_symbol_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
Multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
A549_PCI-34051_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144619
PMC12503973-3972293.f8.xlsx-Supplementary_table7-Supplementary_Table_8_MR-PRESSO_Results_in_the_Discovery_and_Replication_Phases_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
KDM2B-26808549-CHIP-SEQ-HPB-ALL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K82216975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0891
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Melanoma cell line	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE118794_5_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.31726
abnormal craniofacial morphology	IMPC Knockout Mouse Phenotypes	1.0	null
GSE144443_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195568_3_v_4_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE197850_4_v_0_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
cis-regulatory region sequence-specific DNA binding	GO Molecular Function Annotations 2023	1.0	null
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
23132/87	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.82
regulation of cell population proliferation	GO Biological Process Annotations 2023	1.0	null
496100633_TCx_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.21577
BRD-K78712486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2437
GSE128730_0_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Apical junction complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.345
BRD-K80724972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10189
GSE233679_12_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7617064-EMS151900-supplement-Extended_Data_Figure_5_Source_Data.xlsx-CLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314177
Photosystem II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.81
BRD-K98444789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30514
CHLA15	DepMap CRISPR Gene Dependency	1.0	2.56907
BRD-K06296167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25247
PK8	DepMap CRISPR Gene Dependency	1.0	2.36339
GSE77108_3_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7680901-Table_6.xlsx-both_up_GSE117165-SETBP1_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
LANCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08538
Brain capillary endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.855
Visceral hump	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.74
GSE161846,GSE161849_4_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K39526528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08926
regulation of plasminogen activation	GO Biological Process Annotations 2025	1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Neuroepithelioma	DisGeNET Gene-Disease Associations	1.0	null
GSE120612_7_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7478
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.785198
CRCGN008_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6019
GSE146546,GSE146807_0_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
Basal part of cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.799
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
Endotoxemia	DisGeNET Gene-Phenotype Associations	1.0	null
PMC12749580-42003_2025_9274_MOESM5_ESM.xls-Supplementary_Data_2B-Supplementary_Table2B_Full_results_of_the_proteome-wide_MR_in_Ukb_ppp_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE82032_3_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
sequence-specific double-stranded DNA binding	GO Molecular Function Annotations 2023	1.0	null
BRD-K14251637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87181
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.149
WISH cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.726
CRCGN008_HEPG2_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08595
Cutaneous Melanoma	DisGeNET Gene-Disease Associations	1.0	null
GSE165704_0_v_1_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158632_3_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hyperinsulinism	DisGeNET Gene-Disease Associations	1.0	null
GSE145323,GSE145324_1_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.504
GSE130081,GSE130082_0_v_10_neil2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.83848
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-Embryo-Hatchling_1272_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Plasma membrane raft	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.319
KE37	DepMap CRISPR Gene Dependency	1.0	4.57527
chr3_197103084_T_A_b38	GTEx eQTL 2025	1.0	2.36369
PMC9061835-41523_2022_425_MOESM1_ESM.xlsx-S3_Differential_GEX-Table-S3_Differential_expression_analysis_results_for_SOX10-high_versus_SOX10-low_TNBCs_from_the_TGCA_and_METABRIC_expression_datasets_SOX10	Rummagene Transcription Factor Associations 2026	1.0	null
SAS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.537
SDCBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32023
Digestive cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.609
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.29385
LC1SQ	DepMap CRISPR Gene Dependency	1.0	3.81303
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1112
BRD-K87277021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19979
DA-62-QB27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272839
Esrrg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.0224
GSE126463_6_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bisoprolol (hemifumarate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.02117
RPE1SS6	DepMap CRISPR Gene Dependency	1.0	2.64354
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.312
Basolateral plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.906
A549_SRT3025 HCl_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191198
SA1-27219007-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE77108_3_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Six4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.0566
CRCGN012_HEPG2_24H:D22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08834
A549_Tucidinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130327
Epithelioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.669
A549_PCI-34051_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105964
GSE149359_3_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K70343553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22657
Glycyrrhizic acid_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0296431
Gli1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.3745
PMC12629827-mmc8.xlsx-DDR2_KD-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K22193148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0426
GSE200352_9_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154577_6_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.94961
PMC7771094-12920_2020_832_MOESM5_ESM.txt--ATF2_ATF2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K08715020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05027
GSE193993_1_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE129241_4_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211128_4_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE230744,GSE237803_5_v_2_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE185944_5_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235234_2_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_12_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Ivosidenib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214824
GSE111247_0_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204361
GSE94849_6_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K00933790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12987
BRD-K66511507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13485
GSE233679_5_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
UTP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31829
GSE174498,GSE174500_5_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
XRN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65371
RBFOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40212
GSE153871_5_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
FLI1-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE165636_0_v_4_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Metastatic Malignant Neoplasm To Brain	DisGeNET Gene-Disease Associations	1.0	null
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K81522184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21901
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE65617_2_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.72825
GSE134375_0_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140997_2_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K98271666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31436
MYCN-27167114-CHIP-SEQ-NEUROBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE213588_10_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14489
RBMY1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.418
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9314667-Table_1.xlsx-Regulons-MITF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Palonosetron	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.5
PANC0203	DepMap CRISPR Gene Dependency	1.0	4.21702
GSE226115,GSE226116_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11473359-44161_2024_545_MOESM2_ESM.xlsx-Table_16-Table_16_Information_of_genetic_instruments_used_for_Mendelian_randomization_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02420839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2807
BRD-K36002293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03804
BRD-K08241590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03734
GATA6-21074721-CACO-2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Rosiglitazone_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0240239
NOMO1	DepMap CRISPR Gene Dependency	1.0	4.37007
GSE186767_1_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TDRD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06601
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.122
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193993_5_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K45076286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25532
PMC4590705-13062_2015_86_MOESM1_ESM.xlsx-Gene_A_-_TP53-Unnamed_4_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Cell surface	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.3455
PMC8127234-12885_2021_8319_MOESM2_ESM.docx-0-CREB3L1_CREB3L1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K10087503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32896
Captopril_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0222679
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12126244-jci-135-184115-s239.xlsx-Table_3_Suppl_Fig_16-Genes_down-regulated_in_SOX9_low_tumors_744_genes_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
Delamanid_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0220339
GSE210101,GSE210114_7_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PCDHB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31552
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182179_2_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269689
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_CYC116_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0115363
NDUFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20536
GSE214931_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Plasma membrane light-harvesting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.667
FAM98B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63766
GSE128730_4_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Scolex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.857
Endoplasmic reticulum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
TAL1-20566737-PRIMARY-FETAL-LIVER-ERYTHROID-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DC-84-CJ21_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208614
Septate junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.931
RCOR3-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE180789_1_v_0_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Clear cell renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.151
PMPCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49946
SETDB1-19884257-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K06157545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09983
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.58088
NOMO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02939
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
UBN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4037
PMC12062214-41467_2025_59646_MOESM5_ESM.xlsx-HMGA2_activated_repressed-Ensembl_ID_HMGA2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K28923989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18075
Mesothelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.643
SA1-27219007-CHIP-SEQ-ERYTHROID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
recycling endosome	GO Cellular Component Annotations 2025	1.0	null
ZNF417	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4885
BRD-K71671197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59542
DMXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13918
GSE134375_3_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K04546974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08113
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135350_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147664_0_v_1_arid1b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Osteoblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.543
MAP3K2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88065
BRD-K79709959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03738
BRD-K17854062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50633
GSE185519_4_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KA-51-CQ55_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.44889
Post-translational modification: synthesis of GPI-anchored proteins	Reactome Pathways 2024	1.0	null
BRD-K93023309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.29647
Brain cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.542
GSE126463_0_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-NFE2L2_V2-Gene_name_NFE2L2	Rummagene Transcription Factor Associations 2026	1.0	null
ELF3-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K19930413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14138
GSE134375_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K22949587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33466
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_proteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Trametinib (DMSO_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0246054
BRD-K13130949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30829
VA-06-DB75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314762
DDR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81975
CREB1-23762244-HIPPOCAMPUS-RAT	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K67874412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12803
SNU840	DepMap CRISPR Gene Dependency	1.0	2.18327
Pioglitazone_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0154517
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ACTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27585
PMC7217064-IJC-146-3354-s004.xlsx-Table_S5-Supplementary_Table_S5_Genes_significantly_upregulated_in_OC2-transfected_AGS_cell_compared_to_control_ONECUT2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75655
PMC11979751-table_s2_markers_elad055.xlsx-Melanoma_GSEA_state_markers-AP1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
CHD1-26751641-CHIP-SEQ-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S17-Table_S17_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-001_4E_vs_DMSO_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
BRD-K24883912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3513
UQCR11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78729
PMC7708794-mmc2.xlsx-DGE_table_Imm-high_vs_Imm-low-TFT_TBXT	Rummagene Transcription Factor Associations 2026	1.0	null
GSE220520_5_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
microphthalmia	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K21990363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3976
BRD-K18352607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28325
CRCGN015_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3102
BRD-K55044152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00284
A549_A-366_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163564
GSE131798,GSE131804_1_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PCDHB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33791
EIF3J	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77872
Diammonium Glycyrrhizinate_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.025587
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.376
Plasma membrane-derived chromatophore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.741
GSE155567_1_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Vandetanib_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0223931
PMC4728380-ncomms10153-s8.xlsx-High_affinity_MYC_Targets-Unnamed_0_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K00909602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4453
GSE157777_2_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Auranofin_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0301755
3q29 copy number variation syndrome	WikiPathways Pathways 2024	1.0	null
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.492286
GSE242555_1_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
NP2	DepMap CRISPR Gene Dependency	1.0	3.36824
Monocyte_Fetal kidney_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ebf4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.9363
GSE220942_2_v_1_galnt7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169697,GSE169725_0_v_5_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE185519_3_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Severe Combined Immunodeficiency	DisGeNET Gene-Disease Associations	1.0	null
ETV1-20927104-GIST48-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Endoplasmic reticulum lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.6872
BRD-K41433616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11246
BRD-K13572796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00953
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166977
GSE175787_11_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169152_3_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149880_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207999
GSE172016_2_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE48812_11_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE174498,GSE174500_5_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SEL1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00104
GSE134375_6_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
CCNG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32217
Plastid large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.21
Rimonabant_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0297618
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.3133
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23659
GSE200352_5_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE128333_3_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SKNO1	DepMap CRISPR Gene Dependency	1.0	3.81588
TP53-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE96544_1_v_0_mebendazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE197555_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.56
Integumentary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.372
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242555_1_v_0_fn3k_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.955
CRCGN009_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.98702
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212698
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE213588_10_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mild Cognitive Disorder	DisGeNET Gene-Disease Associations	1.0	null
BRD-K06480376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44804
ESR1-26153859-T47D-HUMAN-BREAST-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K09919985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18988
Brain cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.382
Neurofibrillary tangle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.093
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100610_TCx_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15966
GSE140937,GSE140938_1_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
Abdominal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.774
PMC4858740-ncomms11473-s2.xls-HAdV-D9_Cr1b_Library_2-Hit_name_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:E11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24639
nervous system development	GO Biological Process Annotations 2023	1.0	null
GSE214931_4_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
EIF3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55363
GSE214931_1_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE76425_0_v_12_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9564215-pnas.2203480119.sd02.xlsx-OVCAR-5_SCD_KD_cultured_in_low-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.1703
Brain capillary endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.632
GSE235066_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131649_4_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE218727_2_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE236502_1_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12823428-43587_2025_1018_MOESM3_ESM.xlsx-ST12-Supplementary_Table_12_Main_mendelian_randomisation_results_of_plasma_proteins_on_delirium_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149943_1_v_0_cd8a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:F10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15975
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.597
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.622
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
DTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11215
GSE143499_0_v_1_gata6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190177_1_v_0_sgpl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SSR 69071	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.5
GSE118617,GSE118619_2_v_3_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMC1-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
abnormal forebrain morphology	IMPC Knockout Mouse Phenotypes	1.0	null
GSE130864_0_v_1_tincr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25397
ZNF680	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.577
GSE171837_0_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SK-MEL-28 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.986
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4662
KH2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.994
BRD-K95323025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58976
A549_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116633
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.123
A549_Ofloxacin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177936
BRD-K58586013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7204
MECOM-23826213-KASUMI-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K74537058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28375
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE227592_0_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
PGLS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56051
BRD-K10911459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07772
GSE140997_2_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
SCOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40358
BRD-A64915300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4743
GSE128054_1_v_0_myt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE100863,GSE100864_3_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K11057086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30911
PMC12549544-mmc2.xlsx-AA_D14_VS_D21-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K08903301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33208
GSE123689_1_v_0_cbx8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
double-stranded DNA binding	GO Molecular Function Annotations 2023	1.0	null
BRD-K02691653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79079
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEx Heart 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-3.46986
Melanocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.632
BRD-K59984972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99318
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pyloric cecum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.506
AA-52-JS03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.28948
FOXF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23377
GSE206729_4_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K37763427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29682
GSE184356_1_v_2_tfam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RPS17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.645
ELK3-25401928-HUVEC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BCAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27672
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
BRD-K94018786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08952
BRD-K02190643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36866
Marimastat	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142430_2_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_14_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	110.855
CRCGN016_MCF10A.TP53.M_24H:F11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73812
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OCUM1	DepMap CRISPR Gene Dependency	1.0	2.83081
Stomach Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112761,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110248_1_v_6_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3721393-bjc2013326x2.xls-Breast_Cancer_SOX10_Gene_Sig-Unnamed_1_SOX10	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-D-Enh_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K11554989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02953
Sweat gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.958
BRD-K93817456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38951
KYM1	DepMap CRISPR Gene Dependency	1.0	4.56896
SK-N-MC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.675
BRD-K59045095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47679
Procainamide (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0256899
GSE129389_0_v_4_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Ceratobranchial	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.813
GSE202434,GSE202438_9_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of cell population proliferation	GO Biological Process Annotations 2025	1.0	null
BRD-K79147587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4908
GSE223908,GSE223909_4_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12498101-cd-24-1904_supplementary_tables_s1-s12_suppst1.xlsx-S7-Supplementary_Table_7_Human_tissue_RNA-seq_differential_analysis_for_SPOPmut_vs_SPOPwt_AA_vs_AG_and_AG_vs_GG_clone_data_DEG_set_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149880_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235025
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Nearest_Ensembl_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11067031-pnas.2317690121.sd06.xlsx-gene_list_14_txt-Differentially_expressed_genes_between_PML_RARA_GFP_vs_C88A_PML_RARA_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Bimatoprost_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0204847
BRD-K01311880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06654
GSE77108_5_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K76176797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29724
GSE193993_0_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180185_4_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hemochromatosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
NHP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12354
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199092_3_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NFYB-21822215-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K24156533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12514
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.982072
Sunitinib_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0222383
BRD-K87193132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39313
Alzheimer disease specific cell type	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.361
GSE169152_5_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20028734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23357
GSE175787_11_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ubiquitin conjugating enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.92
GSE140651,GSE140653_2_v_6_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
STPG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05192
GSE247764_5_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Phenylephrine (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0137707
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	169.017
PMC11716045-peerj-13-18816-s007.xlsx-Sheet1-ZNF440_ZNF440	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K28694162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21204
GSE147366_1_v_0_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120612_7_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OSGIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8505
Organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205976,GSE205978_3_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206516,GSE206518_5_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K01660763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1601
CRCGN014_HEPG2_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4426
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211215_1_v_0_akr1b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10863267-12864_2024_10083_MOESM1_ESM.pdf-247-ZNF518A_ZNF518A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.126
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.239
PMC9882185-media-4.xlsx-Neuron_KD-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE216273,GSE216292_14_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169152_3_v_1_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SCC4	DepMap CRISPR Gene Dependency	1.0	2.6055
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.522
TRPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41696
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6429
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K97624648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03695
THOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59575
SIN3A-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K28510065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.74158
Dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.193
GSE136232,GSE136234_0_v_1_zpbp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	146.736
GSE235066_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11178519-CTM2-14-e1723-s002.xlsx-STab_19d_HuH28_PBX1-res_HuH28_PBX1_wt_log2FC1_pdaj0_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.28
BRD-K99119142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32915
Egg white	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.573
A549_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182293
Nerve ring	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.596
PMC12917211-Table1.xlsx-Table_S13-Table_S13_Gene-level_perturbation_statistics_from_the_virtual_KLF5_knockout_model_in_malignant_ductal_cells_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152699,GSE152723_3_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE112365_0_v_1_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20-D3_1775_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
wi26va4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.634
BRD-K77591784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00018
GSE154577_2_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Insect tracheal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.969
Cerebrovascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.783
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.34267
BRD-K04614055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04518
GSE126463_4_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311648
BRD-K79324911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02462
BRD-K68119260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65204
A549_Avagacestat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167892
BRD-K18887540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0052
FHIP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79498
GREB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.80087
TMEM59L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54809
PMC11772884-41421_2024_747_MOESM6_ESM.xlsx-7_DEGs_USF2-KO_vs_control-Gene_Symbol_USF2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K89687419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23638
Embryonic tracheal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.61
Fluvoxamine (maleate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0245323
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A90289676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10898
BRD-K75980238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87155
GSE256181_2_v_3_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SK-MEL-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.12
GSE203267_0_v_1_alkbh5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9075502-crc-21-0022-s07.xlsx-WT_vs_KD-Unnamed_0_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PRXL2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79012
Mucopolysaccharidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.296
GSE149621_0_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ranolazine_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0312266
Tazarotene_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00810566
embryonic growth retardation	IMPC Knockout Mouse Phenotypes	1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.304
BRD-K85977749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34588
T-84 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-ensembl_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11178519-CTM2-14-e1723-s002.xlsx-STab_19a_HuCCT1_PBX1-res_HuH28_PBX1_wt_log2FC1_pdaj0_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	196.029
BRD-K82002014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56142
KM-12C cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.664
SLFN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41334
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.297816
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.381
RMC-6236_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0267434
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K07164317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31665
Cancer stem cell_Prostate_Human	CellMarker Gene-Cell Type Associations	1.0	null
FRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03089
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.92785
BRD-K06956443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27674
RPL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01366
BRD-K60188481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06991
PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE190316,GSE190324_1_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K21933068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01492
GSE233679_14_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Astigmatism	DisGeNET Gene-Disease Associations	1.0	null
HSF1-23293686-STHDH-STRIATAL-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Isl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.5129
transition metal ion binding	GO Molecular Function Annotations 2025	1.0	null
CHP134	DepMap CRISPR Gene Dependency	1.0	2.60378
GSE118816_0_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Uterus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FAM221A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7878
GSE127970_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171572_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195568_1_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200794
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
iron ion transport	GO Biological Process Annotations 2025	1.0	null
PMC7403583-41598_2020_69884_MOESM2_ESM.xlsx-Sheet1-Supplementary_Table_1_Differentially_Expressed_Genes_FDR_q_0_05_in_U2932_ROCK2_KD_vs_Scrambled_shRNA_Constrols_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A549_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126203
GSE218378_1_v_0_pbx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
UMUC1	DepMap CRISPR Gene Dependency	1.0	2.86845
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K16554464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78804
Sulfisoxazole_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0244033
PMC12158781-41586_2025_8915_MOESM5_ESM.xlsx-THP1_synergy_up-Gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.577
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SUPT1	DepMap CRISPR Gene Dependency	1.0	2.01065
BRD-K34405227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.40342
DB-28-ZJ81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.484083
GSE135030_3_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC2813300-pone.0008960.s011.xls-SOX2_squamous_signature-Gene_Symbol_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
NPM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73815
BRD-K22670776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97318
GSE188721_2_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K18599462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08579
KYO1	DepMap CRISPR Gene Dependency	1.0	2.47831
GSE157777_1_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08781
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D1_1084_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DOV13	DepMap CRISPR Gene Dependency	1.0	2.21434
A549_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141878
BRD-K10416099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11434
BRD-K91620436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05077
GSE233679_12_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.591
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Genes_differentially_expressed_upon_CSL_silencing_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9314667-Table_1.xlsx-Regulons-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE138815,GSE138817_0_v_2_kdm6a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K09583061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3444
GSE226544_1_v_0_hnrnpa2b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154577_7_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K96096022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73809
Renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.244
PF-06260933_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.027625
BRD-K14987634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98045
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Type IV pilus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.699
TES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00092
HNFA-21074721-CACO-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Ropivacaine (hydrochloride monohydrate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0259094
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.8998
BRD-K03542527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44793
GSE239844_4_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
G15169WU	GlyGen Glycosylated Proteins	1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230227
CNPPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35396
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.693
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263099
PATU8902	DepMap CRISPR Gene Dependency	1.0	4.55161
BRD-K20454972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17341
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K39571490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00068
BRD-K35978846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49447
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11551338-pnas.2411189121.sd01.xlsx-FXR-Unnamed_0_NR1H4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K87781745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42692
GSE133516_5_v_6_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Melanoma	DisGeNET Gene-Disease Associations	1.0	null
XRK3F2_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0186929
Aliskiren_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0154899
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
SMAD2/3-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
A549_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180592
BRD-K92195351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11524
BI-3406_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.034759
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Differentially_expressed_genes_identified_in_bulk_RNA-seq_of_FOXO1-_-_vs_FOXO1_hMSCs_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of plasminogen activation	GO Biological Process Annotations 2023	1.0	null
TUBA1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10137
CRCGN015_MCF10A_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13505
GSE182680,GSE182683_0_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_7_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213228_1_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164874_5_v_14_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
LSM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12476
BRD-K29468949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38553
BE-37-IC77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231561
KDM2B-26808549-CHIP-SEQ-SIL-ALL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC9174882-EMMM-14-e15816-s004.xlsx-MYC_GeneSigs-DANG_BOUND_BY_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE116930,GSE116935_3_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE247764_4_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164874_5_v_8_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Dacinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120624
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4590705-13062_2015_86_MOESM1_ESM.xlsx-Gene_A_-_TP53-Unnamed_8_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.459847
BNIPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43552
CRCGN011_HEPG2_24H:J02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5316
PMC11473359-44161_2024_545_MOESM2_ESM.xlsx-Table_11-Table_11_The_association_of_genetically_predicted_levels_of_proteins_with_the_risk_of_HF_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K61185334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28166
CLPTM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33949
Furosemide_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0154506
PMC11257892-Table_1.xlsx-S2-Supplementary_Table_S2_All_results_of_the_preliminary_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
KIF2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20082
A549_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149427
GSE90552_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
ERG-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K87053028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.42918
CRCGN015_MCF10A.WT.HP_24H:K15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07829
Calcipotriol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.35
BRD-K49005954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06036
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE95302_2_v_3_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.330841
CRCGN014_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.94673
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.297
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TMCO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92803
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239844_6_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF610	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	115.771
Alate adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.01
GMCL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18852
PMC3879300-pone.0084292.s002.xlsx-SPD_dataset-Gene_symbol_HOXD13	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular organelle lumen	GO Cellular Component Annotations 2023	1.0	null
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.295
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.343203
A549_Trametinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110901
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	205.135
GSE229973_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K61924932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80773
GSE185519_4_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PA-80-RV09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283918
BRD-K22246901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80956
GSE70499_0_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K44328896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56
GSE136742,GSE136744_2_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TBCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20449
Matrilin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.901
GSE221633_3_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K50830147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37709
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266012
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234647_0_v_3_regorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TP53-22127205-IMR90-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SC-71-IB68_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209232
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.550434
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CREB5_CREB5	Rummagene Transcription Factor Associations 2026	1.0	null
GATA3-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE201110_0_v_1_sirt4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bhktk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.79
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.91204
PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
TAL1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC11063202-41420_2024_1940_MOESM2_ESM.xlsx-THP1-EP300_KOvsNontarget-gene_id_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226355,GSE226357_1_v_0_ybx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K79631534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01655
GSE233679_6_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-NB4-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_NB4_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
Extracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Corpus amylaceum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.804
BRD-K30812092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5146
TMED8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09729
GSE247764_1_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182179_0_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_MLN8054_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142659
PMC10794847-mmc3.xlsx-PBRM1_KD_up-Table_S2_Differentially_expressed_genes_with_PBRM1_knockdown_in_the_differentiation_state_Related_to_Figure_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.399835
PTTG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25648
A549_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160734
JVE015	DepMap CRISPR Gene Dependency	1.0	3.72189
GSE90710_1_v_0_med13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216326_2_v_0_sulodexide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Extracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00169
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
GSE109285_3_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Brain microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.999
PPM1M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53034
H2BC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51796
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE103309_2_v_0_ube3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K09117810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08493
Pigment granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.558
GSE205163,GSE205164_9_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hydroxyfasudil_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0191806
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211425_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12423794-ao5c05859_si_001.pdf-34-HOXA13_HOXA13	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF-27219007-CHIP-SEQ-ERYTHROID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC11473359-44161_2024_545_MOESM2_ESM.xlsx-Table_9-Table_9_The_association_of_genetically_predicted_levels_of_proteins_with_the_risk_of_coronary_heart_disease_CHD_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
ZR751_BREAST	CCLE Cell Line Proteomics	1.0	2.89097
A549_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022607
GSE200352_11_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101336_1_v_0_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
positive regulation of transcription by RNA polymerase II	GO Biological Process Annotations 2023	1.0	null
Trimetrexate_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0282046
A549_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148017
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE219195_4_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9539848-PATH-257-579-s008.xlsx-NCOA2_vs_NCOA2-ctrl-geneSymbol_NCOA2	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF397	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20815
GSE230744,GSE237803_0_v_2_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_6_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11426526-ppat.1012555.s011.xlsx-DEG_MDDC_Jurkat_LPS_vs_MDDC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Gemfibrozil_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0270602
Pyridoxine (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0291572
C6orf89	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.44367
BRD-K65250438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27096
BRD-K75497233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07966
GSE143847_2_v_3_inhba_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of plasminogen activation	GO Biological Process Annotations 2025	1.0	null
PMC11063202-41420_2024_1940_MOESM2_ESM.xlsx-THP1-EP300_KOvsNontarget-gene_name_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
PSMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87761
SEC61A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66955
UPCISCC029A	DepMap CRISPR Gene Dependency	1.0	2.06559
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.815
GSE234637_2_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	89.1244
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE175787_11_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GABP-17652178-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K98451611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06552
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
UGP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12611
GSE118490_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K13970506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47508
BRD-K40418847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01888
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A75087829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06833
GSE116930,GSE116935_1_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
positive regulation of extracellular matrix organization	GO Biological Process Annotations 2023	1.0	null
GSE190316,GSE190324_0_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
SLC38A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81995
Olanzapine_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0247806
BRD-K74971765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19625
Vaginal fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.598
H3C14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03525
BRD-K37719063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08459
GSE118077_4_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K07802542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73027
A549_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137235
BRD-K03902845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20681
BRD-K23666684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4024
Capillary endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.293
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.1031
PPP1R2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23199
GSE48812_8_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Neurodegeneration with brain iron accumulation 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.279
GSE214842_0_v_1_atf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of cellular component organization	GO Biological Process Annotations 2023	1.0	null
BRD-K04195898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59899
Acne	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.156
BRD-K64698855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23301
BRD-K92767663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05036
CRCGN017_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35055
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	181.906
RBPJ-21746931-IB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K32520360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06978
GPRASP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44904
BRD-K98301999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46216
ZSCAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21747
BCL3-23251550-MUSCLE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K84710243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32829
GSE205163,GSE205164_5_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Toxic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.149
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE232631_0_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K73834056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45304
Ferroxidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.678
GSE229309,GSE229314_4_v_1_elavl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K08650286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70117
GSE233679_6_v_4_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE219195_0_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184210_0_v_3_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lenalidomide (hemihydrate)_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0352992
Pentoxifylline_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0216362
JUN-26020271-SMOOTH-MUSCLE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
endoplasmic reticulum lumen	GO Cellular Component Annotations 2023	1.0	null
GSE76425_0_v_10_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Punctate palmoplantar keratoderma type I	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
HC-01-FD24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271084
PMC8787225-Data_Sheet_1.xlsx-STable_2_DEG-Supplementary_Table_2_1150_up-_and_down-regulated_differential_expressed_genes_upon_GATA2_activation_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K14139166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16603
VDR-24787735-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC6113333-41598_2018_31192_MOESM11_ESM.xlsx-Sheet1-H1_NFIC_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185139_1_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5640240-ppat.1006668.s013.xlsx-MAX_ChIP_shEP400-1-Unnamed_6_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218727_0_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9770089-fgene-13-1051269.pdf-1-TCF7L1_TCF7L1	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular organelle lumen	GO Cellular Component Annotations 2025	1.0	null
BRD-K58025976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23417
BAIAP2L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39132
Urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
CTCF-21964334-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HEC6	DepMap CRISPR Gene Dependency	1.0	2.18901
PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_ATF1-gene_ATF1	Rummagene Transcription Factor Associations 2026	1.0	null
Post-translational protein modification	Reactome Pathways 2024	1.0	null
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
DZIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35729
NALCN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00467818
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.397676
GSE140322_3_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K19474742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01138
BRD-K83370434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10301
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.404732
DF-03-OP38_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346819
BRD-K87654551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04634
SW1990	DepMap CRISPR Gene Dependency	1.0	3.22783
Connective tissue cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
Trifluridine_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0267694
JUND-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
GSE65617_2_v_3_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140322_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.591
SDHC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22475
BRD-K05479183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00578
BRD-K85162396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40487
CRCGN017_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27276
regulation of substrate adhesion-dependent cell spreading	GO Biological Process Annotations 2025	1.0	null
PMC9174260-41467_2022_30960_MOESM6_ESM.xlsx-S3-RAS2_unique_GATA2-Gene_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K05220907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61944
BRD-K63779242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3847
GSE210383_0_v_1_trim71_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
GSE174406_2_v_0_lin28b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195568_3_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCMEC/D3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.483
PMC4531812-13058_2015_618_MOESM11_ESM.xlsx-Metabric_Sparse_KM_976-TFAP2B_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233679_6_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE145323,GSE145324_3_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.893
CRCGN014_HEPG2_3H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10434
GSE135030_11_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0511
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-GENE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K15794956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59387
GSE185944_2_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tucidinostat_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0219975
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.529
GSE158182_4_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.591
PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
NDUFAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49704
BRD-K96758498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68297
GSE119978,GSE180930_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Yolk granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.078
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Caveola	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.322
Lumateperone (tosylate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0177809
GSE206729_2_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11473359-44161_2024_545_MOESM2_ESM.xlsx-Table_13-Table_13_MR_Steiger_analysis_to_infer_the_MR_causal_orientation_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K01022714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83446
A549_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127499
A549_Azacitidine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0300502
HACD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62537
KU-812F cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.526
RNF169	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13004
BRD-K85554193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35363
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53046137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84352
GSE205163,GSE205164_2_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K09487932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26301
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30457
GSE232631_4_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K47783463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70755
BRD-K87743988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45475
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	154.17
A549_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124883
JHH4_LIVER	CCLE Cell Line Proteomics	1.0	16.5323
CTCF-27219007-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE227698_5_v_0_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_0_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Monocrotaline_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0112815
BRD-K35026224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31761
GSE169590_6_v_5_rptor_human	RummaGEO Gene Perturbation Signatures	1.0	null
Integumentary system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.156
PMC8995879-Table_1.xlsx-exome_variants_MAF_0_01-Gencode_34_hugoSymbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
SMURF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90719
GSE200839,GSE233826_5_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11237048-41598_2024_64364_MOESM1_ESM.pdf-29-ZFHX2_ZFHX2	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.9372
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.356
BRD-K29525414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53291
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304774
PMC9630632-Table1.XLSX-diff_exp_genes-Group_1_vs_2_AND_Group_2_vs_3_NOT_Group_1_vs_3_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213715_0_v_1_iqgap2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146247_0_v_1_sirt7_human	RummaGEO Gene Perturbation Signatures	1.0	null
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	94.3222
EHD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05729
K562_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161745
ROGDI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28944
GSE144443_5_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205976,GSE205978_1_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Ki16425_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191598
NALM16	DepMap CRISPR Gene Dependency	1.0	2.57649
PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256648
AIFM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09125
GSE140651,GSE140653_2_v_7_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.222
GSE162276_5_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K33016067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05674
PMC7617064-EMS151900-supplement-Extended_Data_Figure_7_Source_Data.xlsx-D23_NFIX-Logfold_change_threshold_1_0_1_NFIX	Rummagene Transcription Factor Associations 2026	1.0	null
negative regulation of substrate adhesion-dependent cell spreading	GO Biological Process Annotations 2025	1.0	null
GSE234637_1_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
RSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84341
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Coelomocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.217
SLC22A23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51259
Egg coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.708
ZEB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97664
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Oxaprozin_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00877079
GSE249098_3_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23200057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.235
Early endosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	3.0
TSEN15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22483
496100394_TCx_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0963
A549_Alisertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178384
VDR-33458620-PRIMARYEPITHELIAL-HUMAN-PROSTATE	ChEA Transcription Factor Targets 2022	1.0	null
Diphenhydramine_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0186836
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303689
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285855
BRD-K58028568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46624
Brain microvascular endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.506
HEY	DepMap CRISPR Gene Dependency	1.0	2.44992
BB-93-VT73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.577475
Mantle cavity	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.895
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234811
SCMCRM2	DepMap CRISPR Gene Dependency	1.0	2.72107
GSE242199_9_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
A549_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136228
BRD-K54362440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18859
CRCGN016_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.36222
BRD-K55835264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37572
GSE118794_0_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LY2801653	DeepCoverMOA Drug Mechanisms of Action	1.0	0.48
GSE131887_1_v_4_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PTAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5048
GSE138789_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Idarubicin (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0134998
Berbamine_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0290925
BRD-K09454191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39907