association	dataset	threshold value	standardized value
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3WW-01A-22R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
L-Eflornithine (monohydrochloride)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0300163
SU8686	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	3.40773
decreased bone ossification	MGI Mouse Phenotype Associations 2023	1.0	null
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of skeletal morphology	GWASdb SNP-Phenotype Associations	1.0	0.091903
hsa-miR-607	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
mantle zone of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04593
Perturb_11298_KO_Bmal1_SRP060295	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.50666
primary motor-sensory cortex (samples)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.920321
GTEX-PLZ5-2026-SM-2S1O4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890779
Osimertinib (mesylate)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0299083
GTEX-XOTO-0011-R5A-SM-4B657	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892225
GSE193177_1_v_2_st266_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL-12T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.84722
GTEX-WHWD-0426-SM-3LK83	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43988
Anterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.20399
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
Mild pre-eclampsia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.449
PRDM14-21183938-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CQ-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
UA-39-TN76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.605085
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.529793
PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26452
GSX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04118
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
JA-63-WB39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279173
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0926-SM-32PLX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947295
basolateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.32075
Lung squamous cell carcinoma_LUSC_TCGA-33-4582-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11A-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.826116
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Chimp_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20317
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAL120	CCLE Cell Line Gene Expression Profiles	1.0	1.40913
GSK1059615_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0283472
Loperamide (hydrochloride)_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0114083
GTEX-U3ZN-1426-SM-3DB87	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71848
GSE123638,GSE123639_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
eGFP-HDAC8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Accessory sex gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.542
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19048
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3335-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36162
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958312
K562_Ellagic acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163004
Pitavastatin (Calcium)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0162347
YA-44-LW45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.383852
hsa-miR-3689e	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
periventricular stratum of r5Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.769
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DDX39A	Pathway Commons Protein-Protein Interactions	1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.030175
GABPA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
FA-65-UA27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.341803
SHMT2	Pathway Commons Protein-Protein Interactions	1.0	null
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.39683
Mesothelioma_MESO_TCGA-TS-A7PB-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPI1	ENCODE Transcription Factor Targets	1.0	null
PMC10803041-elife-86204-supp2.xlsx-Bulk_-_Snc-KD_in_HT-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54728
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10028
MYCN	ChEA Transcription Factor Targets	1.0	null
105KC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.896055
SUZ12	ENCODE Transcription Factor Targets	1.0	null
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851211
WM-35 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.121
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_body_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.25127
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26787
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MY-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210885_2_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A822-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EP300_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P78B-0426-SM-2I5F5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917536
hsa-miR-603	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
hsa-miR-3617	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE158834_10_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
2653_ENTPD7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.61621
hsa-miR-4768-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87835
Prostate adenocarcinoma_PRAD_TCGA-CH-5788-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G402_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	5.0386
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SRC_overexpression_277_GSE15161	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.9451
cell part	GO Cellular Component Annotations 2015	1.0	null
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.466263
(S)-Crizotinib_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0185175
GSE113005_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-W5X1-0826-SM-3GILN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2846
hsa-miR-4643	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GTEX-XQ3S-0926-SM-4BOPI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918444
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.888738
GSE143512,GSE143513_0_v_1_nr4a3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
L-Eflornithine (monohydrochloride)_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0120099
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8T8-1426-SM-3DB9H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22726
Perturb_16742_KO_Cdc42_SRP331884	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.47104
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.00961
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Chlorhexidine (diacetate)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0422798
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07033
K562_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016375
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.98726
PMC9745835-supp_079195.122_Supplemental_Table_1.xlsx-ADAR-KD-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PSMG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2836
Perturb_16579_KO_Crebbp_SRP174041	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.19316
Perturb_10614_OE_Stk4_SRP121622	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	14.8895
GSE135030_8_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6407
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210527
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266305
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35271
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE144443_10_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PWN1-0126-SM-2I3FK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993327
UBXN1	Pathway Commons Protein-Protein Interactions	1.0	null
AD-54-FG24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.291135
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09104
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.98567
inner SZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.981517
Perturb_11917_KO_Apoe_SRP135284	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.79094
GSE150072,GSE169209_4_v_10_qser1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-69-UN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205813
Erdafitinib _C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0165385
primary auditory cortex (core)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.847423
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16544
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Perturb_4961_KO_Dot1l_SRP214101	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.40741
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_RCOR2_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
ZBTB49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02882
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Thymol_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.029676
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.995802
Primary somatosensory area, upper limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08654
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.908331
hsa-miR-141	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
Perturb_3016_KD_SNHG1_SRP313438	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-OIZF-1526-SM-3MJGY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25089
Lung squamous cell carcinoma_LUSC_TCGA-68-7755-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE235945_1_v_0_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92881
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.83227
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CD-35-BD44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270391
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A953-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46869
H3K4me1_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE198165,GSE198166_0_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RVH421	CCLE Cell Line Gene Expression Profiles	1.0	1.98733
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.928079
TE-26-XS06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.685102
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7434-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ivabradine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.18
GSE192771_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.891595
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38466
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42355
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5786
MKN74	CCLE Cell Line Gene Expression Profiles	-1.0	-1.84306
SIN3A	ENCODE Transcription Factor Targets	1.0	null
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.906548
HOXB4-20404135-EML-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
molecular layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12006
K562_WHI-P154_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197228
mediodorsal nucleus of thalamus_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0117
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KAT2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Piriform-amygdalar area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04434
GTEX-U8XE-0626-SM-3DB8U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86409
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.95633
NCI-H1793	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.91675
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.91675
Raltitrexed_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0294593
mitochondrion	LOCATE Predicted Protein Localization Annotations	1.0	null
MDAMB175VII	CCLE Cell Line Gene Expression Profiles	-1.0	-1.77505
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.964198
GAK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12819
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BECKER	DepMap CRISPR Gene Dependency	1.0	2.1919
Linear nucleus of the medulla	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24855
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11933
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.93756
Disease Progression	HuGE Navigator Gene-Phenotype Associations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-5668-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE74490_0_v_1_triptolide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ATF3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZH-0326-SM-2HMKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18582
Primary somatosensory area, mouth	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06729
seminal vesicle	HPA Tissue Protein Expression Profiles	1.0	1.36575
CB-24-AT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.749053
TCF3-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
Bosentan (hydrate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0112704
TOV112D	DepMap CRISPR Gene Dependency	1.0	2.18633
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.0924
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Capmatinib_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0282592
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204145
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_prom_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
POLR2AphosphoS5_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16852_KO_Hnrnph1_SRP068520	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.6614
Tendril	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.761
9886_XAB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.26502
PECAPJ34CLONEC12	CCLE Cell Line Gene CNV Profiles	1.0	1.45334
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r9 part of the basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17559
GSE216757_0_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAK-901_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00456108
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.88089
GSE48812_3_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Primary somatosensory area, lower limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04708
posteroventral (inferior) parietal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.897262
Abiraterone acetate_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0184274
RBBP5	ENCODE Transcription Factor Targets	1.0	null
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF1	ENCODE Transcription Factor Targets	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2914-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cancellous bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.245
GTEX-Q2AG-0526-SM-2S1PW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0706
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.995802
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_8-ILL1_T_Cells_FOXP3_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.63097
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.50947
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DA-15-PU65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203283
Fractures	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.6699
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.830004
Posterior parietal association areas, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3485
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB33_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ARH77	DepMap CRISPR Gene Dependency	1.0	2.03808
vitamin c_homo sapiens_gpl570_gse11919	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
mantle zone of r10Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68757
GSE161055,GSE161056_1_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RD-92-QT24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.44691
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
periventricular stratum of r4Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62146
K562_KW-2449_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230208
H3C14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28712
lhx8_18509161_newborn_ovary_lof_mouse_gpl1261_gds3254	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.192878
GSE200352_10_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tuberomammillary nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28936
ELF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.504789
8853_TFIP11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.74612
ATP1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04838
HCFC1	ENCODE Transcription Factor Targets	1.0	null
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6977700-aging-12-102667-s004..xlsx-Stage2-The_identified_459_dysregulated_LmiRM-CTs_in_stage_2_of_MI_4-6_days_after_MI_using_our_method_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE180813,GSE180815_1_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r10 part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64905
Bosentan (hydrate)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0219676
Zbtb2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.3788
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.908331
Valdecoxib_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0243231
MYC_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFG8-0626-SM-3GILJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39083
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2844
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45576
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Costunolide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159143
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.33939
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Regorafenib_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0384912
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35137
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5876-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5875-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NANOG-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Secondary motor area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01863
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5WG-2226-SM-4LMI3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828622
GTEX-OHPN-0011-R7A-SM-2I5FI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995297
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211177,GSE211178_4_v_10_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
layer 3 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37693
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.908331
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE127790_13_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Anterolateral visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25389
KM-12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30905
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_16845_KO_Kcnj10_SRP241402	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.61781
musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.438544
PSMB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25776
BAT3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.971
bone disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.438544
PMC10624900-41467_2023_42825_MOESM13_ESM.xlsx-Module_3-ZNF195_ZNF195	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_0_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CFPAC1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.53864
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lactate (calcium)_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0165539
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.38115
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.02178
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8253
WM88	CCLE Cell Line Gene Expression Profiles	1.0	3.40795
Dapagliflozin_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0185879
PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
ELAVL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55646
FLI1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Aurora A Inhibitor I_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177051
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95557
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NG-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.762326
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GREB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20944
hsa-miR-3619-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Perturb_15644_KD_Cebpb_SRP160879	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.54286
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.380428
Perturb_5872_KD_Nudt21_SRP336206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.65628
Glasdegib_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0351738
L-Thyroxine (sodium salt pentahydrate)_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0131409
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RO-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE231891_1_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.889298
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
skmel30	HPA Cell Line Gene Expression Profiles	1.0	1.48847
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.549124
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NE-06A-21R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5971
hsa-miR-200b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
H3K4me1_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TU-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RO-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OACM51	DepMap CRISPR Gene Dependency	1.0	2.13164
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XOTO-0011-R9A-SM-4GICI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.896679
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70N-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE48812_0_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EP300_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.43558
HC-01-FD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213303
POLR2AphosphoS5_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2A2-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49613
Perturb_17311_KO_Rhox10_SRP302924	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.08047
SUPHD1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43604
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03426
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.27139
GSE125014_6_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.44073
GTEX-XLM4-0011-R9A-SM-4AT45	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02794
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Artemether_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0321786
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08476
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF354C	JASPAR Predicted Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3473-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_1761_OE_Notch1_SRP311399	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.41969
Primary somatosensory area, lower limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20404
gata4_18812176_jejunum_tissue_lof_mouse_gpl1261_gds3486	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.010212
JHH1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50105
Uridine_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0186368
hsa-miR-106a	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
Acute Myeloid Leukemia_LAML_TCGA-AB-2863-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5497-01A-02R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_10616_KO_Ttn_SRP136441	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.09254
GSE218814_1_v_0_suv39h1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.55763
GTEX-UPK5-0326-SM-3GAF3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3433
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.29864
GTEX-WFG7-0726-SM-3GIKO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42272
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7245
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850795
CTCF_GM12875_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5871_KD_Nudt21_SRP336206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.73229
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ8I-0126-SM-4BOPL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09721
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-S4-A8RO-01A-12R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rhombomere 10	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32166
Vandetanib_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0254741
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315935
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D2REFED4h_641_AR-D-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74943
GTEX-U8XE-0926-SM-3DB8V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33388
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	1.0	1.77264
NCIH1385	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59559
GSE128730_4_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r10 part of vagal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66949
Decitabine_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0169191
SKMEL28	CCLE Cell Line Gene Expression Profiles	1.0	2.00414
NCI-H1568	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.0979
GSE129389_0_v_6_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60142
NP3	DepMap CRISPR Gene Dependency	1.0	2.00463
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.68357
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81948
primary motor cortex (area M1, area 4)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.899224
10911_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.73865
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39594
GSE199034_1_v_2_pirfenidone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF347	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17544
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.95406
CTCF_GM12872_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBSN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13318
GSE239844_7_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.963398
DC-45-WU45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208587
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999588
GSE182680,GSE182683_10_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217115_3_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH146_LUNG	CCLE Cell Line Proteomics	1.0	2.0853
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207464
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2BC21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08147
Sarcoma_SARC_TCGA-K1-A6RV-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203072_2_v_3_rpl3l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_M344_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185476
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gracile nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06065
superficial stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27751
GTEX-PX3G-1526-SM-48U11	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969747
Perindopril (erbumine)_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0123341
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial crista	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.104
STAT3	ENCODE Transcription Factor Targets	1.0	null
FLI1_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
spleen	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.23564
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Trametinib (DMSO_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0144362
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77113
Perturb_9760_KO_Ctcf_SRP273104	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.37745
MCF7_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019464
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE186810,GSE186813_2_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146381
hsa-miR-3689c	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
CHD1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-596	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
TCF3	ChEA Transcription Factor Targets	1.0	null
Loperamide (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00786162
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	1.0	2.15505
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4480	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.36844
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.30324
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.850795
inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10884
GATA2	ChEA Transcription Factor Targets	1.0	null
CF-50-QK79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.724947
hsa-miR-4264	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
CREB1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE251992_1_v_0_saracatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TYK2_knockdown_176_GSE44652	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.41107
icSARS CoV_0Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.28366
Prostate adenocarcinoma_PRAD_TCGA-EJ-5517-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IPC298	CCLE Cell Line Gene Expression Profiles	1.0	1.93454
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPI1_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
myb_16205643_primary_monocytes_gof_human_gpl570_gse2816	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.09981
USF1_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.81343
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DC-84-GJ21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297336
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Belumosudil_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0412997
AC-44-UR36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.768238
hsa-miR-93-5p	MiRTarBase microRNA Targets	1.0	null
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
SP in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19642
Perturb_11321_KO_Dicer_SRP041679	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
FA-92-JL46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274713
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPRC5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05289
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91956
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A50I-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.546113
NCI-H520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04812
hsa-miR-216a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Perturb_14942_OE_hPRDM15_SRP182668	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.86705
Lung squamous cell carcinoma_LUSC_TCGA-66-2778-01A-02R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retrosplenial area, dorsal part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0662
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.749788
osteoporosis	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.438544
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15336
SRF_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83081
E2F6_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.22348
ATF3_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteromedial visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23988
GCT	DepMap CRISPR Gene Dependency	1.0	2.27429
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39567
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.833304
H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE228413_2_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293356
FLI1	ChEA Transcription Factor Targets	1.0	null
GTEX-VUSG-0726-SM-3GIK1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66312
GA-23-VF89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345174
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.03059
Rutin (trihydrate)_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.018579
GTEX-XMD1-0011-R11A-SM-4AT5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01766
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CD-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
BATF	ENCODE Transcription Factor Targets	1.0	null
SLIRP	Pathway Commons Protein-Protein Interactions	1.0	null
NVP-BHG712_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0373051
GTEX-X585-2426-SM-46MW2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88483
H3K4me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-QQ-A8VF-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1495
GSE48812_3_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
AA-56-JY17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.435426
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ULK-101_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0314882
GSE211128_7_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21777
AB-74-VK99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24904
Perturb_10313_OE_hAPOL1_G2_SRP075245	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.2335
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_HSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of r10BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.06875
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCIH1963	CCLE Cell Line Gene Expression Profiles	-1.0	-2.25755
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9013128-NIHMS1795992-supplement-6.xlsx-ARID2_MUT_Upregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
RXRA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-2L-AAQA-01A-21R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.569041
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU72-0011-R2A-SM-2TF6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848428
SU-DHL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02728
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.17705
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-93	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4076-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4908_MCOLN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.508345
t30-blood-rna_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.37616
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.84383
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE148066,GSE157787_9_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240439_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32239
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20071
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
BABAM1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE144443_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WK11-0626-SM-3NMAV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06992
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1718
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4T-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ciclopirox_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0358195
BHLHE40_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H4K20me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-RU72-0011-R5A-SM-2TF6U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828091
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	1.0	2.09212
H3K36me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-UJHI-0006-SM-3DB8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03024
GSE77795_2_v_1_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AF-67-LZ82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222815
GSE148066,GSE157787_9_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
amygdaloid complex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.01427
GTEX-Q2AI-1326-SM-2S1PL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976481
GSE110440_2_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SP1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-548c-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
Enzalutamide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.21
LN18_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	2.58385
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RE-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EW1	DepMap CRISPR Gene Dependency	1.0	2.39489
Osteoporosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.669
HES2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2061
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09296
DE-73-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.628555
HEK-293A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.69
blastocysts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.50776
UIMC1	Pathway Commons Protein-Protein Interactions	1.0	null
Left_Ventricle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.890495
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149075_3_v_9_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11C-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225418
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	3.72728
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K5ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
rnf2_20805357_megakaryocytic_l8057_lof_mouse_gpl1261_gse33659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.23318
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
9+0 motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.566
Raltitrexed_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0238367
dorsal cortical nucleus of inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38315
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A66X-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182854_2_v_0_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.623871
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PSDG-1526-SM-48TCY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10485
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Anterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.00449
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.87589
RDES	DepMap CRISPR Gene Dependency	1.0	2.05112
COLO 206F	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.990159
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.24703
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
r10 portion of the hypoglossal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24277
ventrolateral prefrontal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.39821
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
OV56	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22022
Rosiglitazone_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0295942
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7838-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242333_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.803353
Simotinib_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0203472
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.959006
SHISAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18576
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.65797
Integral component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.936
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.506859
liminal part of the r7 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03383
Thyroid	GTEx Tissue Gene Expression Profiles 2023	1.0	5.72044
GSE158834_1_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NFATC2	JASPAR Predicted Transcription Factor Targets	1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.93746
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3X1-01A-12R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWSA-0626-SM-2XCBD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26933
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
XBP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5984
HCT-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08456
PRPF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28571
CD-47-YL43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.455246
Apalutamide_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0136224
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.953776
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ectorhinal area/Layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.88385
Entecavir (monohydrate)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0213748
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
intermediate part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05996
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_5244_KO_Dnmt1/Dnmt3a/Dnmt3b_SRP275780	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.5601
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.885997
GTEX-T6MN-0011-R9A-SM-32QOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941276
MYOG	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SMAD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5089
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Perturb_5294_KO_Dgcr8_SRP137730	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.46968
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10609
Perturb_5482_KD_Ctnnb1_SRP130920	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.59762
hsa-miR-3123	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02192
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94402
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.9173
hsa-miR-1243	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A6RX-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AT7519_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0227126
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PRDX5	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1763_KD_Tcf1_SRP311399	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.00873
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXP1	ChEA Transcription Factor Targets	1.0	null
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Infigratinib_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0199675
PB-63-WH18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.540839
MAX_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.882807
ZBTB33_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100480_HIP_no dementia_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.31694
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14006
sin3a_22783022_mcf7_lof_human_gpl570_gds4388	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.22461
r9 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01982
NCIH810	CCLE Cell Line Gene CNV Profiles	-1.0	-1.96286
Primary somatosensory area, unassigned, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45733
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	1.0	1.08653
CD40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41104
Lung squamous cell carcinoma_LUSC_TCGA-85-8071-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MZ in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885362
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.420758
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.34606
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33374
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_10_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HK2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54493
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-8353-01A-21R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35837
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958717
GTEX-XUJ4-1826-SM-4BOOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832374
PMC6811834-sby183_suppl_supplementary_data_set_1.xls-ZNF804A_DEX_FDR_0_01-Gene_Symbol_ZNF804A	Rummagene Transcription Factor Associations 2026	1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30051
ATAD1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03233
TAF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Gandotinib_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155314
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim29_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RU72-0326-SM-2TF5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64889
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.87934
COLO 205	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840437
SREBF1	JASPAR Predicted Transcription Factor Targets	1.0	null
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20481
r6 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12964
ARID3A	ENCODE Transcription Factor Targets	1.0	null
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.855641
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
head of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10321
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
USF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE132948,GSE132949_2_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tirabrutinib (hydrochloride)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0251742
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1914
callosal sling	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00025
OA-54-FL10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263938
Tirabrutinib (hydrochloride)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.036075
midbrain reticular formation, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.24046
intermediate stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17559
hsa-miR-3689f	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
GTEX-QDVJ-1226-SM-48U1V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940981
K562_BMS-911543_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162545
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.847531
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-0226-SM-4DM7I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934073
NCIH1568	DepMap CRISPR Gene Dependency	1.0	2.12466
RAJI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02626
Bone disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.018
PTPN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15275
lateral mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.73866
hsa-miR-4766-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GTEX-WH7G-0426-SM-3NMBJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828506
Lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13518
XC-81-LR46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245741
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893728
PARK7	Pathway Commons Protein-Protein Interactions	1.0	null
Auranofin_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0180927
PPAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72225
placenta_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.24302
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
SD-69-QA40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317528
substantia nigra, pars compacta, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.87353
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24759
orbital frontal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02851
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE61117_0_v_1_trim24_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07028
hsa-miR-548c-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.013856
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ATF3_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3192	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.1057
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214631
Lenalidomide (hemihydrate)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0175272
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51N-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Canagliflozin_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0280922
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
INTS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69022
Primary motor area, Layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08488
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
NOA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59387
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199606_1_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Avagacestat_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0270474
SP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08622
COLO783	CCLE Cell Line Gene Expression Profiles	1.0	1.70713
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.8646
CREB3L4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9032
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MA-06-DJ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.490055
Esmolol (hydrochloride)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0221857
bone remodeling disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.438544
Perihypoglossal nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1682
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE157594_5_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Primary somatosensory area, mouth, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06072
TTC442	DepMap CRISPR Gene Dependency	1.0	2.10375
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
retropontine reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1116
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18012
K562_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015523
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.48878
Perturb_3375_KO_Mir31_SRP106571	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.11314
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anteromedial visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23463
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4772-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GTEX-XK95-1026-SM-4GIDV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863612
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sirolimus_mus musculus_gpl1261_gse5332	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Niclosamide (olamine)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00914331
ribavirin_homo sapiens_gpl570_gds4391	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GDI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38763
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-BatSRBD_48Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.59794
hsa-miR-5095	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GSE60217_1_v_0_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZFP42-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
SARS-dORF6_96Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.72608
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.963647
Nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22379
GSE48812_9_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
SF3B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45579
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Fibrosis	CTD Gene-Disease Associations	1.0	1.03345
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12628
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.76652
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_2_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.877796
GTEX-WL46-0011-R7A-SM-3LK7X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880053
Adrenocortical carcinoma_ACC_TCGA-OR-A5KV-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2759-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pimozide_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0131607
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WC-33-YP46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.506647
hsa-miR-130b-3p	MiRTarBase microRNA Targets	1.0	null
Perturb_10946_KO_Nr1d1_ERP117724	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.57081
Calcaneal bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.763
GSE146074_9_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sodium Salicylate_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0196874
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.66585
embryonic lethality during organogenesis, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-6666-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-548u	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Citalopram (hydrobromide)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0308224
r9 part of trigeminal transition zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36049
FOXP2-21765815-NEURO2A-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-UTHO-0011-R5A-SM-3GIJD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.867606
abnormality of the skeletal system	GWASdb SNP-Phenotype Associations	1.0	0.081526
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_11728_KD_Klf4_SRP338421	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.49365
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1167
primary visual cortex (striate cortex, area V1/17)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.890318
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.54981
Bosentan (hydrate)_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0267439
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.7359
rpmi8226	HPA Cell Line Gene Expression Profiles	1.0	1.04505
GSE214248_0_v_1_cxcl8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Temporal association areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.90515
POTEE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07848
GSE223908,GSE223909_1_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47324
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CREB1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPL-1026-SM-3MJGI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01932
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48512
SIX5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11044
UNC119	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25537
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81E-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2917-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-548m	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
Perturb_3334_KO_Sh2d2a_SRP215303	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.17789
KCL22	DepMap CRISPR Gene Dependency	1.0	2.30182
hsa-miR-146a	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
JF-30-FW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.312697
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Larotrectinib sulfate_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00826801
Brain Lower Grade Glioma_LGG_TCGA-VW-A7QS-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BA-06-RE84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.398403
MICU1	Pathway Commons Protein-Protein Interactions	1.0	null
EA-93-KT88_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235357
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.89764
connective tissue disease	GWASdb SNP-Disease Associations	1.0	0.163268
SMARCB1	ENCODE Transcription Factor Targets	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_11207_KO_Zhx2_SRP332476	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.34278
Koolen de Vries syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
AB-80-CK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233079
Imiquimod (hydrochloride)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0102417
Entecavir (monohydrate)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0345795
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03066
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Lumbar spine	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.634
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46443
Perturb_5142_KO_Ring1a_ERP008873	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.26619
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.86607
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIX5_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CP21R7_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0103552
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64294
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Tetracycline (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0121922
Rectum adenocarcinoma_READ_TCGA-F5-6814-01A-31R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal raphe nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.66155
bone remodeling disease	GWASdb SNP-Disease Associations	1.0	0.466852
Lung adenocarcinoma_LUAD_TCGA-75-5147-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5868_KD_Cpsf6_SRP336206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.522
Rifaximin_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0290937
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65574
GSE184902_4_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43708
Perturb_17442_OE|Mut_Tal1|Akt_SRP366791	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.21816
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303011
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11028
GTEX-WHPG-0826-SM-3NMBF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24009
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-5337-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE108675_3_v_0_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WSU-FSCCL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16675
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.70978
Posterior parietal association areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1493
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
basomedial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00637
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.58733
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE124920_1_v_2_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A89Z-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE89767_1_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pancreatic_Islets	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.40847
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.999535
AB-04-NN16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358858
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32599
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
UGGT2	Pathway Commons Protein-Protein Interactions	1.0	null
FD-62-ZB67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314511
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2228
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SF-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
GSE102505_4_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_5206_KO_Dgcr8_SRP137729	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.32587
GSE140322_3_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE184902_4_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	1.0	1.15245
GTEX-REY6-1726-SM-48FDL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90178
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08937
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201673
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.687447
r10 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02155
r5 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6017
SP in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.845433
DE-98-FC24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.415107
oculomotor nuclear complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.47913
TMPO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21308
QE-93-PG25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243527
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
layer 1 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27351
primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.876903
hsa-miR-1910	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEL4-0926-SM-3GAD1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01225
hsa-miR-3140-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
superficial stratum of OCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33435
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE115542_5_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-1126-SM-3NMBY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43318
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.843091
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Nevirapine_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0141779
Hypoglossal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17372
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STAT3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.98536
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09367
Mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.575
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03976
GTEX-W5WG-1726-SM-4LMI5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.988614
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75012
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12478272-mmc1.xlsx-Table_S7-Supplementary_Table_7_Proteome-wide_MR_and_sensitivity_analysis_results_using_the_brain_pQTL_dataset_from_Wingo_et_al_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.10387
r9 portion of ambiguous motor nucleus (postmigratory)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.29032
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.73344
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.927217
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-1026-SM-3MJGF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918001
GSE213588_10_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
UACC-893	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12851
Perturb_13253_KO_Dgcr8_SRP165279	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.91686
skin	HPA Tissue Gene Expression Profiles	-1.0	-1.07781
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-512-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Gefitinib_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0230427
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.880744
mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BATF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_3_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84338
18440302-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
intermediate stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.08629
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hMPV_72Hour_18234263_GSE8961	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.08142
Lung squamous cell carcinoma_LUSC_TCGA-43-A474-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.56274
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05278
CC-49-CQ25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.394125
PMC12494973-41467_2025_63880_MOESM1_ESM.pdf-438-ENSG00000091831_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.947221
H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NOL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09045
Rosiglitazone_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0160592
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30413
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875906
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3925-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
STAU1_DELETION_GDS3370_56_human_HeLa	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-WRHU-0226-SM-3MJFV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992704
GSE188458_2_v_4_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary somatosensory area, mouth, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.598617
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43165
RUNX1	ChEA Transcription Factor Targets	1.0	null
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
r7 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06517
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_10651_KD_Syncrip_SRP065017	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.95493
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03507
POLR2A_K562_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169205_3_v_2_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
THAP11-20581084-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37889
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.45162
H3K79me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.907431
GSE166920_6_v_8_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SOHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3635
SNU601	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38591
GTEX-RWS6-1126-SM-47JXC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19004
Perturb_11206_KO_Mapk3/Mapk1_SRP331927	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
SREBF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.63206
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Clotrimazole_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0220182
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
17616640-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AC-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anastrozole_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0130795
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7893-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7401-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEWO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.943867
hsa-miR-371b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
NCIH441	DepMap CRISPR Gene Dependency	1.0	2.39593
posteroventral (inferior) parietal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.88089
GSE226316_3_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916786
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.67753
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.2097
bone resorption disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.438544
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
bone disease	GWASdb SNP-Disease Associations	1.0	0.203676
EC-01-PH79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360497
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.956819
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rostral group of intralaminar nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.89721
VPS4A	Pathway Commons Protein-Protein Interactions	1.0	null
periventricular stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.74943
MAFK	ENCODE Transcription Factor Targets	1.0	null
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PLK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00114
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.419013
GTEX-T5JC-0826-SM-32PMC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99882
MDAMB134VI	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43933
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1341	CCLE Cell Line Gene CNV Profiles	-1.0	-2.36319
WM115	DepMap CRISPR Gene Dependency	1.0	2.32379
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Posterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.85282
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11952_OE_MYC_SRP355809	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
r1 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.07928
A549_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134364
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AF-83-BX08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203458
hsa-miR-4257	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
FOSL2	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3308-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.45149
GTEX-TSE9-0011-R1A-SM-3DB7E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904296
GSE160246_2_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
skin_5f	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.962836
Quinidine (15% dihydroquinidine)_NCI-H2347	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0169342
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7446
Perturb_12672_KO_Smarca4_SRP191908	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.7303
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126345_7_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXM1	ENCODE Transcription Factor Targets	1.0	null
CEBPB_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14945_KD_Parp1_SRP102079	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.69309
SKMM2	CCLE Cell Line Gene CNV Profiles	1.0	1.92513
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SUIT-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18062
BE-70-CU78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255513
GSE158834_1_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05717
CREB3L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4379
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178340_1_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03513
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.86089
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
WM1799	CCLE Cell Line Gene Expression Profiles	1.0	1.41099
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.7902
NCIH661_LUNG	CCLE Cell Line Proteomics	1.0	2.20838
GSE226249_0_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Digitoxin_HepG2/C3A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0110175
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pyridoxine_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0289218
HEY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7166
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.963647
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Quercetin_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142404
ETS1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14757
hsa-miR-761	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.299
GTEX-TSE9-0726-SM-3DB8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.954897
Perturb_5149_KO_Thap11_ERP126456	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.0086
SMAD4	ChEA Transcription Factor Targets	1.0	null
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYB	ENCODE Transcription Factor Targets	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K4me3_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3428-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
GTEX-U3ZH-0326-SM-3DB7A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61989
GSE215351,GSE215794_2_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.92188
Posaconazole_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0271532
Clotrimazole_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0153635
GSE158834_10_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.58497
SK23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.944932
GBA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1414
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4829
YD8	CCLE Cell Line Gene CNV Profiles	1.0	1.41519
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.29881
Perturb_4723_KD_Npas4_SRP166456	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.8891
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39302
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-99-SN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.343733
EFM19	CCLE Cell Line Gene CNV Profiles	-1.0	-1.88763
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927942
ZBTB33_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE82104,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Quinestrol_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0153224
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Relugolix_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0377594
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.946484
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46958
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lactose intolerance	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.521
LB-100_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0386519
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC-827	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.63013
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0167
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29148
RSRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2513
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-200a	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.46728
HES1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8082
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.96204
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82754
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55972
GSE233647_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_DMAP1_20946988	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE188570,GSE188571_3_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2013
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160001,GSE160670_3_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Penfluridol_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.014264
JD-10-HW02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260634
JAK2_knockout_79_GSE26188	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.7361
Regorafenib_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0468755
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SIX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.95274
Glasdegib_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0282889
MFE319	DepMap CRISPR Gene Dependency	1.0	2.2581
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55494
hsa-miR-3620	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
MZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.913334
Primary somatosensory area, barrel field, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66562
GSE172189_0_v_1_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.338
PRR36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58446
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14842
Perturb_7070_KO_Lmna_SRP173589	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.05338
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39475
GET1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09568
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_up_VENN-697_elements_included_exclusively_in_HIF1_genes_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
DB-21-FY25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245299
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15534
GSE95685_2_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU182	CCLE Cell Line Gene CNV Profiles	1.0	1.49165
Pioglitazone_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0292286
hsa-miR-548y	TargetScan Predicted Conserved microRNA Targets	1.0	0.175726
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.878399
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12014
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUZC-1726-SM-4BRWS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08218
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GINS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60925
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Oxaprozin_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0202563
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71021
Anterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.10967
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29184
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.97
Perturb_13195_KO_HDAC3_ERP127280	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.90127
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.83134
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.876804
Talc_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0226581
LJI308_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0127768
K562_IOX2_10µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01474
tail of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.4564
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38921
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4151-01A-01R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QLQ7-0526-SM-2I5G3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16782
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263388
IRF1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-579	TargetScan Predicted Conserved microRNA Targets	1.0	0.140752
NCIH1963	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39767
TCF12_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, barrel field, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.18554
AZD-7648_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0107518
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.72
Perturb_7549_Mut_UPF1_SRP298492	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE179002_0_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-21-1075-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3145-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
Daptomycin_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0155461
hsa-miR-3159	TargetScan Predicted Conserved microRNA Targets	1.0	0.226173
Belumosudil_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0251451
7-Hydroxycoumarine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
Volasertib_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.012215
Perturb_4960_KO_Dot1l_SRP214101	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.62599
GSE217405_3_v_2_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gemfibrozil_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0183267
Perturb_16784_KD_CCNA1_SRP313541	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SIN3A_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.82996
NCI-H1648	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.01248
mediodorsal nucleus of thalamus_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.85513
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0426-SM-2XCEZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947197
Perturb_4031_KO_Foxp1_SRP260102	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.32097
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05319
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
PSMB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37266
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.417586
OE19	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
Acute Myeloid Leukemia_LAML_TCGA-AB-2941-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5208_KO_Dgcr8_SRP137732	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.44051
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.864484
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.55199
Primary somatosensory area, unassigned, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67117
Verapamil_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.016892
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AASDHPPT	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26D-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLR25	CCLE Cell Line Gene CNV Profiles	1.0	1.35836
IGR1	CCLE Cell Line Gene Expression Profiles	1.0	1.38632
body of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.956464
MHHCALL2	CCLE Cell Line Gene CNV Profiles	1.0	1.39581
GSE207914_4_v_7_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pemetrexed_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0277818
Nimesulide_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0221751
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Vastus lateralis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.747
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40206
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hippocampus	HPA Tissue Protein Expression Profiles	1.0	1.36575
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.375263
PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
ChIP_NANOG_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
TAL1-20566737-PRIMARY FETAL LIVER ERYTHROID CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55G-0526-SM-2TC5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27647
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19995
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFATC1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Retrosplenial area, lateral agranular part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24185
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K91ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.04091
periventricular stratum of r6BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00768
SARS-BatSRBD_36Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.80392
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-2.10021
GSE158834_1_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
dorsal thalamus_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.75449
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Unnamed_6_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178383
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ME-54-JY76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282886
Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6131-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	1.0	2.46112
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54038
Sarcoma_SARC_TCGA-SI-A71O-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.43637
Perturb_15608_KO_Dnmt1_SRP247926	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.06952
Procainamide (hydrochloride)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0153799
Elagolix sodium_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0228609
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Endomembrane system	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.485
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-24	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14072
mantle zone of r7Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0356
TRIM28	ENCODE Transcription Factor Targets	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
Ruminal fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.814
Fractures, Bone	HuGE Navigator Gene-Phenotype Associations	1.0	null
SNRNP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14542
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832003
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE132386_2_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE192771_2_v_1_mt1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
SPI1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217115_3_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sinomenine_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0260431
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.945055
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01818
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.08891
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.11715
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24948
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFG8-0726-SM-3GILP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03617
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NRF1	ENCODE Transcription Factor Targets	1.0	null
Poisoning	CTD Gene-Disease Associations	1.0	1.2393
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dorzolamide (hydrochloride)_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00801709
ATF3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8586238-41467_2021_26788_MOESM6_ESM.xlsx-S2A_CDE_genes-S2A_CDE_-_genes_of_the_two_CCD_genes_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.70379
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EU-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.861833
Ribociclib_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0264814
Cobimetinib_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0244332
Perturb_8507_KO_Gata4_SRP277626	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.98815
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UC-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_3089_KO_Fkbp5_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.72888
Prostate adenocarcinoma_PRAD_TCGA-EJ-5522-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Aprepitant_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0282861
Digitoxin_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0347033
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99901
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1762_OE|KD_Notch1|Tcf1_SRP311399	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.69439
HCC15	CCLE Cell Line Gene Expression Profiles	-1.0	-1.60166
Perturb_6339_KO_Des_SRP272249	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.02794
Perturb_16442_KD_IL13RA2_SRP314695	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.5324
CA922	DepMap CRISPR Gene Dependency	1.0	2.00296
MM426	DepMap CRISPR Gene Dependency	1.0	2.27009
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsal thalamus_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1642
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Celecoxib_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0268949
MAX_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-FC-A4JI-01A-11R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Digitoxin_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0307646
MYC-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.926432
Prostate adenocarcinoma_PRAD_TCGA-G9-6363-01A-21R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.38746
Cardiomyocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.089
Anteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56873
DVL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25139
intermediate stratum of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60655
CREB1	ENCODE Transcription Factor Targets	1.0	null
Gli2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.4864
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5892-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12788_KO_Gba_SRP385574	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.7214
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13752
Trimetrexate_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0340019
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMRM-0526-SM-2I5GA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45032
GSE160083,GSE160084_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7064337-elife-51373-supp2.xlsx-652_genes_up-regulated-List_of_652_genes_up-regulated_after_PHF19_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BL-41	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.07178
testis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.9641
Pancreas	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.43512
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Supplementary_Table_2A_Contrast_ATF4-def_control_vs_HCT116_control_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Temporal association areas, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10765
SARS-CoV_24Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.2025
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.611395
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.7557
EE-98-PF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26871
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.83417
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31664
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3466-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13579
GSE185922_1_v_2_riok2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE159893_2_v_1_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
RMGI	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55781
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6337
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.412542
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-36-TL21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303307
putamen, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.96804
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
c-Kit-IN-1_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0149249
12734205-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-OHPN-0011-R4A-SM-2I5FD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977278
GTEX-VJYA-0826-SM-4KL1M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01181
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.44967
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
layer 2 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30866
TAK-733_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0220047
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50944
RD-90-OY66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.741129
MIB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.02
GSE147834_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.813761
Artemether_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.022876
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.630371
hsa-miR-3682-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OOBK-1026-SM-48TC2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83717
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-4.02035
Lateral reticular nucleus, magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06866
H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.979805
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.8314
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12897
GSE125782_3_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Berbamine (dihydrochloride)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0454021
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856827
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.837451
496100420_PCx_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14749
RNAi_-666_19345177	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Amsacrine_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0189094
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1963
GSE111385_2_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00687
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.908331
Perturb_1993_KD_Zbp1_SRP154381	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.53677
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.212475
GSE233566_1_v_2_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.22869
K562_BMS-911543_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170823
Perturb_14791_KD_SF3A2_SRP191866	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_13142_KO_Ngly1_SRP166093	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.79115
HEC108_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	3.36649
GSE172490_5_v_3_junb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TA-57-FF07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.419206
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.169
hsa-miR-4766-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
heart_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.60376
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8833
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Supplementary_Table_2F_Contrast_ATF4-def_IGG_8h_vs_HCT116_IGG_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.979562
Retinoic acid_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0170432
VPS4B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE205316,GSE205317_2_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GC-54-IZ89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.42316
fat_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.868142
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.30526
DNTTIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33055
CTCF_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4514	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
USF1_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.594669
GTEX-V955-0726-SM-3GAFG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3486
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.7836
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.21401
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cuneus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00852
POLR1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47503
7389_RNF34_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.576306
Trimetrexate_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.03412
Perturb_16878_KO_Trrap_SRP198540	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.14739
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.47491
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.960553
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
subthalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15409
ZNF143	ENCODE Transcription Factor Targets	1.0	null
KDM5A	ENCODE Transcription Factor Targets	1.0	null
GNAL	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 3 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73377
H3K4me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_5837_KO_Bgn/Dcn_SRP295503	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.97665
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OC-10-FB51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315221
TFK1	DepMap CRISPR Gene Dependency	1.0	2.01117
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.457974
Tetracycline (hydrochloride)_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.033342
AT7519_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0366691
Perturb_6951_KO_Rbm20_SRP328560	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.97005
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27112
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-dORF6_24Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.55775
Benproperine (phosphate)_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0150321
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NFE2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Idoxuridine_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.01223
Prostate adenocarcinoma_PRAD_TCGA-EJ-5516-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0
THAP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT-144	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.47063
PC-14	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.51579
GSE222758_0_v_4_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4500	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
CB-11-GB40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.641908
CLPX	Pathway Commons Protein-Protein Interactions	1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.91738
UTP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90841
Berbamine (dihydrochloride)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.028567
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26563
HEC108	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56026
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Posterior parietal association areas, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3284
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-370	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
K562_AT9283_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160075
Primary visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53369
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.82914
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A110-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EMILIN complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.887
Osteoporosis	HuGE Navigator Gene-Phenotype Associations	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6UA-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Tazarotene_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0308099
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TOPBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45249
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-19-BK71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.812167
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-SE5C-0326-SM-4BRWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15768
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-20-WA90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251548
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE186471_1_v_0_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
WM2664	CCLE Cell Line Gene Expression Profiles	1.0	1.6639
hsa-miR-519d	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
GSE148066,GSE157787_5_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-214	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Gallic acid_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0251343
locus ceruleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.13192
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887127
Prostate adenocarcinoma_PRAD_TCGA-EJ-5525-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
GSE164135,GSE164137_0_v_1_fbxw7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.866493
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.42222
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.950407
GSE182680,GSE182683_10_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Budesonide_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.015106
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_ESRRB_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GAL3ST4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07983
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16933_OE_Hlx_SRP070641	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BF-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-48-ZT65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278461
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_down-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-5396-01A-02R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE118766_1_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-35-4123-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74773
GSE81193_3_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5838-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r9 part of the lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56332
Kidney renal papillary cell carcinoma_KIRP_TCGA-UZ-A9PO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE198165,GSE198166_8_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Belumosudil_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0248888
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.903982
GSE62843,GSE64371_4_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6977700-aging-12-102667-s004..xlsx-Stage3-The_identified_641_dysregulated_LmiRM-CTs_in_stage_3_of_MI_1_month_after_MI_using_our_method_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
lung_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.958526
disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.438544
BCAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68058
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
primary auditory cortex (core)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.462
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cardiac muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.995
layer 1 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81402
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.865299
ECC12	CCLE Cell Line Gene Expression Profiles	-1.0	-1.80623
POLR2A_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199606_1_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-2054	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
lateral subdivision of BNST	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.14904
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DU 145	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4982
IZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.834934
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.901885
Perturb_11992_KO_Tet2_SRP119769	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.67136
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.80984
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A6DT-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21517
Perturb_11993_KO_Tgfbr2_SRP133892	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-12.2858
JUN	ENCODE Transcription Factor Targets	1.0	null
CC-04-YT10_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226118
Perturb_3703_OE_Fst/Lin28b_SRP319706	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.64564
6024_PABPC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.731166
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7870-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE111385_0_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1758_KO_p300/Tet2_SRP250516	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.5214
LIPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09571
intermediate stratum of r10BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.07224
Vandetanib_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0159827
GSE247862,GSE247863_4_v_3_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HZ-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EC-71-PH39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314414
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.0193
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_ZR75_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
JMSU1	CCLE Cell Line Gene CNV Profiles	1.0	1.7067
GM12878	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.09295
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of r10Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.83273
GTEX-P78B-0726-SM-2S1O2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889137
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4796-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.241055
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.56126
K562_PF-3845_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0348661
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
organelle	GO Cellular Component Annotations 2015	1.0	null
GSE158834_10_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226644
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216005
GTEX-SIU7-0926-SM-4BRX1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927785
GTEX-NFK9-1626-SM-3LK5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07279
Lung squamous cell carcinoma_LUSC_TCGA-22-0944-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205053
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-0226-SM-3GIKR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72234
QF-00-NO42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.334573
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S32W-0826-SM-4AD5Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908222
GSE130396_1_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74025
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.915615
hsa-miR-200c	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31851
hsa-miR-519c-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.2689
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
substantia nigra reticulata, m1 part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27946
Ritonavir_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.022632
HI-TOPK-032_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0359651
H3K9me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02252
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
GTEX-V1D1-0726-SM-4JBH7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856608
Brain Lower Grade Glioma_LGG_TCGA-DU-A76L-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SREBF1	ENCODE Transcription Factor Targets	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34262
CD-16-KY17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.494421
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
increased mean corpuscular volume	MGI Mouse Phenotype Associations 2023	1.0	null
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TT-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
K562_Ramelteon_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0232069
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19301
GTEX-U4B1-0726-SM-4DXUA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898748
Regorafenib_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0451841
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3689a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
hsa-miR-4755-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE166783_4_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
GSE231648_0_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7123-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU308	CCLE Cell Line Gene CNV Profiles	1.0	2.26446
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.856512
decreased bone strength	MGI Mouse Phenotype Associations 2023	1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100574_HIP_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.19691
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42759
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.667973
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.42359
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18471
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
FOXP2_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE220520_6_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
C-33 A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.74317
RUNX1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16311
Tirabrutinib (hydrochloride)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00946033
r8 part of linear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36881
ARL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54217
nucleus of the diagonal band, left, horizontal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13923
GSE93124_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K23me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NDUFA5	Pathway Commons Protein-Protein Interactions	1.0	null
Fulvestrant_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0106037
basal nucleus of meynert, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20323
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09882
Brain_Germinal_Matrix	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.824891
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.45162
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RTL8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24064
GSE217873_1_v_2_nusap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06767
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	1.0	3.34357
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE244072_4_v_6_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pemetrexed_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0175744
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE48812_0_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12111
hsa-miR-559	TargetScan Predicted Conserved microRNA Targets	1.0	0.069137
K562_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209042
Sulfatinib_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0199231
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	1.0	2.42771
6493_PNO1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.538637
primary auditory cortex (core)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04976
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.14384
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78L-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE225735_0_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.28016
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95321
GSE220520_3_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-DMOG_-_HIF1A-gene_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TFDP1_TFDP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE48812_11_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SK-N-SH	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.55921
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.309905
GSE217552_3_v_2_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_17316_KO_Tardbp_SRP321767	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.70189
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0197
PMC6977700-aging-12-102667-s004..xlsx-Stage1-The_identified_3126_dysregulated_LmiRM-CTs_in_stage_1_of_MI_1_day_of_MI_using_our_method_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CREB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114232_10_v_11_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate stratum of r7Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02155
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
valproic acid_homo sapiens_gpl570_gse14973	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MKN7	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.94664
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09719
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12745
GSE91015_0_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_upregulated-Gene_name_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CP21R7_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0229369
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Daidzin_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0254172
GSE88819_0_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	1.91218
GTEX-XPVG-0826-SM-4B654	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950297
AA-54-WG39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300994
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
c-Kit-IN-1_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0310817
cd4.Tcell	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.973561
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08626
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.35673
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42045
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AD-51-FB60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.419771
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34594
PC-87-OG75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237853
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Docetaxel (Trihydrate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0189304
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46137
ESRRB	ChEA Transcription Factor Targets	1.0	null
K562_Amisulpride_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182744
r7 portion of ambiguous motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26593
GSE150669_0_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A2058	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02175
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5903_NUP93_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.37343
SRF_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TET1	ChEA Transcription Factor Targets	1.0	null
GTEX-OOBK-0008-SM-3NB27	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958142
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90692
hsa-miR-146b-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.998671
Norwalk Virus_HG23_19515767_GSE15520	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.2512
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07322
Perturb_11156_KO_Tsc1/p62_SRP069010	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.99236
Econazole_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0313957
hsa-miR-548n	TargetScan Predicted Conserved microRNA Targets	1.0	0.159923
NCIH1048	DepMap CRISPR Gene Dependency	1.0	2.11761
GSE158834_10_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Primary somatosensory area, trunk	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23862
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21273
MRPL53	Pathway Commons Protein-Protein Interactions	1.0	null
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.934723
HD-62-KE69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33252
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.7655
CL-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22022
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me2_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DC-47-KV62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26938
K562_Baricitinib_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155837
ESRRG_Deficiency_GDS2811_638_mouse_Fetal heart - Homozygous null mutant	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Sodium Salicylate_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0218821
outer plexiform zone in extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.41611
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281844
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.982094
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T8EM-0826-SM-4DM76	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12787
AE-06-FY47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.659693
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30365
GTEX-QDVJ-0426-SM-2I5FW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1427
SNW1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33929
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CFPAC1	DepMap CRISPR Gene Dependency	1.0	2.35993
H3K79me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE134375_0_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE242367_1_v_0_dpp9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883605
GTEX-R55E-1026-SM-2TC5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64035
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-PK-A5H8-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232597
PMC9013323-13577_2022_685_MOESM7_ESM.docx-5-HIC1_HIC1	Rummagene Transcription Factor Associations 2026	1.0	null
ESRRA	ENCODE Transcription Factor Targets	1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.880403
Lung adenocarcinoma_LUAD_TCGA-64-1678-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sonidegib_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0232827
POLR2A_K562_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.989212
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BB-87-SF89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369224
K562_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182682
RELA_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCO2	DepMap CRISPR Gene Dependency	1.0	2.0358
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28985
Golgi apparatus	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.485
GSE180200,GSE180201_15_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9092
OE19	CCLE Cell Line Gene CNV Profiles	1.0	2.1927
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962343
hsa-miR-4729	TargetScan Predicted Conserved microRNA Targets	1.0	0.092495
GSE247862,GSE247863_2_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIN3A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36684
Kidney Chromophobe_KICH_TCGA-KN-8428-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.58615
Bosentan (hydrate)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0058127
USF1	ENCODE Transcription Factor Targets	1.0	null
posteroventral (inferior) parietal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.886052
GTEX-S7SF-0526-SM-3K2BC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03822
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.908331
pineal_day	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.03335
hsa-miR-592	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
cetuximab_homo sapiens_gpl570_gse21483	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8438
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.01062
USF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57467
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
PMC7925689-41467_2021_21687_MOESM10_ESM.xlsx-A_HIF1A-Unnamed_8_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
E2F4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A641-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293454
GSE173232_2_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
mitochondrion	GO Cellular Component Annotations 2015	1.0	null
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4146-01B-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216538_7_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6389
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27115
Perturb_5833_KO_Hnrnpl_SRP042164	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.55516
GTEX-SE5C-0626-SM-2XCDV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51248
Verapamil_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0232887
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r10 part of ventral parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.83273
YWHAE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04107
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Frontal pole, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37617
CE-04-PX35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.424491
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
posterodorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31543
PRDM1	JASPAR Predicted Transcription Factor Targets	1.0	null
hsa-miR-3609	TargetScan Predicted Conserved microRNA Targets	1.0	0.23348
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3N_Peaks_YAP1FAM118B_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
SIRT6	ENCODE Transcription Factor Targets	1.0	null
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4066_IGF2BP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578095
CD-16-KY17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319589
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15828
GSE155852_0_v_1_apigenin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
r10 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82095
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Canagliflozin (hemihydrate)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0236046
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37286
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7402-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3919	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
hsa-miR-548i	TargetScan Predicted Conserved microRNA Targets	1.0	0.136254
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.54128
THAP1	ENCODE Transcription Factor Targets	1.0	null
CGB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25895
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
plasma membrane	LOCATE Curated Protein Localization Annotations	1.0	null
periventricular stratum of r2BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22379
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JX-A3PZ-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.2456
JUND	ENCODE Transcription Factor Targets	1.0	null
GTEX-PX3G-0326-SM-2I3EO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33454
GSE217071_3_v_0_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_1813_KO_N4bp1_SRP255180	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.28392
TAF1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tirabrutinib (hydrochloride)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0203406
Ouabain (Octahydrate)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0340664
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YY1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22024
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7312
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06342
orbital frontal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.86899
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.941606
hsa-miR-548d-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
Perturb_5150_KO_Thap11_ERP126456	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.37108
ARNT::HIF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2212
superficial stratum of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.29032
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H4K20me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HU-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
VCX3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16188
MDAMB435S	CCLE Cell Line Gene Expression Profiles	1.0	1.99755
Nucleus ambiguus, ventral division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32364
GRANTA-519	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30905
inner SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20946
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_8512_KO_Bmal1_ERP009958	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.40779
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52433
SH4	CCLE Cell Line Gene Expression Profiles	1.0	2.24279
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acetazolamide_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0211523
ATG9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00123
Primary visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.8496
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24329
GTEX-WY7C-1126-SM-3NB3A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.96986
prostate_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.967297
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.827341
r9 part of ventral parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61155
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00177
GTEX-XMD1-2826-SM-4AT5F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828977
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.06292
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17345
disease	GWASdb SNP-Disease Associations	1.0	0.027174
hsa-miR-3689b	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
PMC6977700-aging-12-102667-s006..xlsx-Sheet1-The_identified_1173_dysregulated_LmiRM-CTs_in_MI_using_our_method_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LS411N	DepMap CRISPR Gene Dependency	1.0	2.02091
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Tucidinostat_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00601787
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_10683_OE_hURI_SRP026667	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.11717
sevoflurane_homo sapiens_gpl570_gds2772	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE171180,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_3272_KO_AMPK_SRP389002	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.56118
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MT-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCV JFH-1_48Hour_20200238_GSE20948	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.4134
GSE145215_0_v_1_krt13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ID-69-QF93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.322027
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-1926-SM-4DXTR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986827
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
r9 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03735
Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
heart muscle	HPA Tissue Gene Expression Profiles	1.0	2.16278
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18062
hsa-miR-548ab	TargetScan Predicted Conserved microRNA Targets	1.0	0.136254
AC-36-TL21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.370491
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7692-01A-12R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Perturb_6536_KO_Cldn5_SRP305395	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.76501
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.142
Rifaximin_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0376503
SKMEL5	CCLE Cell Line Gene Expression Profiles	1.0	1.5648
K562_Alendronate sodium trihydrate_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216404
ventrolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.861896
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-347-ZNF484_ZNF484	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WY7C-0526-SM-3NB3D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916934
POLR2A	ENCODE Transcription Factor Targets	1.0	null
Perturb_15115_KD_Rtn4_SRP278924	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.232
outer SZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04139
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PBX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29905
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Artemether_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0180376
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE173578_1_v_0_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
USP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37545
GTEX-P4PQ-1026-SM-3NMCN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0902
BRE	Pathway Commons Protein-Protein Interactions	1.0	null
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.92188
GSE96991,GSE97117_5_v_2_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21531
GSE197564,GSE198513_2_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04267
GSE148066,GSE157787_8_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_decrease_in_MLL-AF4_ChIP-seq_signal_2198_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
A549_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138778
SRF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
L-Thyroxine (sodium salt pentahydrate)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0250503
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135030_3_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JUN_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Z8-1826-SM-3K2BH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840423
GSE157777_1_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
putamen, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.877864
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	1.0	2.2473
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
r7 part of ventral parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01982
Dexmedetomidine_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0320981
USF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Daidzin_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0435911
H3K36me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ciclopirox_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0226942
Dorsal motor nucleus of the vagus nerve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32572
cerebellar cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2438
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19598
GTEX-X88G-0126-SM-47JZ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893738
intermediate stratum of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82095
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.13384
DMS53	CCLE Cell Line Gene CNV Profiles	1.0	1.40225
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F0-01A-12R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60901
GTEX-V1D1-0526-SM-4JBGW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907708
GTEX-XGQ4-0326-SM-4GIEE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31078
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A560-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7858-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
HMEL	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53294
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7440-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PGA1	DepMap CRISPR Gene Dependency	1.0	2.18904
NF-21-HQ00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226522
HEC265	CCLE Cell Line Gene Expression Profiles	1.0	1.50607
SW 982	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.837018
GTEX-WFJO-0626-SM-4LVMC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01496
TYK2_knockdown_35_GDS4754	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.41107
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Valdecoxib_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0227669
GTEX-U8XE-1126-SM-3DB8W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02071
USF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r5 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27751
GSE86507,GSE86509_3_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ETS1	ENCODE Transcription Factor Targets	1.0	null
GTEX-Q2AI-0426-SM-48U13	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10116
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.09582
GTEX-S33H-1226-SM-4AD69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959208
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_TMP195_10µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017244
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20679
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55601
Dihydroartemisinin_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0271597
Temsirolimus_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.017705
PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LT-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-0011-R7A-SM-2TF5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88727
RAD21	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63W-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRF_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
Posterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.90515
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Loperamide (hydrochloride)_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0179571
VMRCLCD	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38194
A549_Filgotinib_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135544
decreased compact bone volume	MGI Mouse Phenotype Associations 2023	1.0	null
SRF-21415370-HL-1-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.50637
CEBPB	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7783-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284205
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11627
JIYOYE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2282
GSE169152_3_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_16111_KO_Dnm2_SRP139918	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
MD-17-VD78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282311
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.908776
GSE153124_4_v_0_dsg2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleus accumbens, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04832
NIPA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3328
Pioglitazone_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0389006
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920974
HUH28	CCLE Cell Line Gene CNV Profiles	1.0	1.33798
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-1926-SM-3MJGB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903389
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82363
intermediate stratum of r9Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26593
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36237
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.859373
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Benztropine (mesylate)_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00710164
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5693-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELK4	ENCODE Transcription Factor Targets	1.0	null
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114992,GSE114993_0_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.21384
GSE163297_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE236262_2_v_1_trim28_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
15735024-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE76771_1_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MELK_druginhibition_186_GSE50227	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.70512
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-589	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE48812_8_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Rosiglitazone_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0202842
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATF2	ENCODE Transcription Factor Targets	1.0	null
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.887256
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.59224
primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.6569
GSE186460_0_v_2_baricitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HIF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2224
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262256
GSE118766_2_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30212
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37417
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
posterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36621
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE229671,GSE229673_3_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6869-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-CA-04-2009(H1N1)_24Hour_None_GSE37571	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.37373
GB-73-QS80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253342
Extensor digitorum longus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.758
ZNF384	ENCODE Transcription Factor Targets	1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11363
GTEX-Q2AG-0008-SM-48U2K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28445
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.937067
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-23-PM31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.548445
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149359_2_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.700229
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE211128_9_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU8	DepMap CRISPR Gene Dependency	1.0	2.41203
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16849_KO_Hnrnph1_SRP068520	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Verapamil_HepG2/C3A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0262427
Daptomycin_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0189963
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17356
Ligustrazine_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0267983
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211128_7_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.963618
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23361
Lung squamous cell carcinoma_LUSC_TCGA-63-5128-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_KLF4_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Diphenhydramine_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0320916
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.34509
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904726
r7 part of parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47324
SIX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6496
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3385_OE_miR155_SRP108825	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.548
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Chimp_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
EP300_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE166944_3_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tadalafil_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.021572
liminal part of the r10 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68497
ATF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.271
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.8921
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25797
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.588011
GSE211177,GSE211178_8_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4051124-1471-2164-15-256-S16.XLSX-WES_IPD-RBCK1_2-Target_RBCK1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_12046_KO_Eed_SRP327420	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.06073
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.700727
Harringtonine_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0106018
GSE146074_0_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bone remodeling disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.63
Ectorhinal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58893
EC-01-PH79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232376
GTEX-X3Y1-0226-SM-3P5Z5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04309
GSE182680,GSE182683_0_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2806-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.0143
Brain Lower Grade Glioma_LGG_TCGA-CS-5395-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-let-7f	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7125-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-197	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GTEX-X3Y1-0426-SM-3P5Z4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937199
GSE125157_1_v_0_piceatannol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ECC12	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7014
GTEX-POYW-0726-SM-2XCEO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63552
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185519_4_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE231648_4_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SKNBE2	DepMap CRISPR Gene Dependency	1.0	2.08424
Vinblastine (sulfate)_HepG2/C3A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0113285
POLR2AphosphoS5_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cytarabine (hydrochloride)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0367176
TKT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54736
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.60173
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Aedesaegypti	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.562
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.614155
H1-5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59573
hsa-let-7e	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
retina	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.06521
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3M_Peaks_YAP1MAMLD1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Lamin filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.524
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.850304
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC9038526-mmc1.xlsx-postCOVID_LPS_vs_healthy_L-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.950006
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.970695
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.922022
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COV644	CCLE Cell Line Gene CNV Profiles	1.0	1.74033
PIK3CA_activemutant_56_GSE17785	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.15543
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.44137
Perturb_16856_KO_Hnrnph1_SRP068520	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.48621
YD15	CCLE Cell Line Gene CNV Profiles	1.0	2.51145
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835867
globose nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.7594
FGFR1_mutant_26_GDS4046	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.49615
LRRC47	Pathway Commons Protein-Protein Interactions	1.0	null
GSE178340_7_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J7-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Resveratrol_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0257032
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.13536
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE118766_2_v_3_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196962_4_v_3_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.62185
ATAD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19645
hsa-miR-548b-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22572
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A6EA-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.825754
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
7519_RPS28_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.35027
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
embryonic lethality prior to organogenesis	MGI Mouse Phenotype Associations 2023	1.0	null
PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.877796
Sarcoma_SARC_TCGA-X6-A7W8-01A-21R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOP62	CCLE Cell Line Gene CNV Profiles	1.0	1.84771
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1584
Perturb_11553_OE_SIRT6_SRP394380	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.90909
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8339-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_G007-LK_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148589
MYBL2	ENCODE Transcription Factor Targets	1.0	null
GTEX-XQ8I-0926-SM-4BOOF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999737
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-548q	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GTEX-X5EB-0626-SM-46MVQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990587
AF-41-QY60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.471785
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48644
GTEX-O5YV-1026-SM-3LK72	GTEx Tissue Sample Gene Expression Profiles	1.0	0.980868
IF-75-AJ33_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.447585
PAX5	ENCODE Transcription Factor Targets	1.0	null
GSE178227_1_v_2_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3N_Peaks_YAP1FAM118B_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
K562_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168435
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.337911
GSE88819_7_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
G6PC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08362
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956552
GTEX-X4XY-0326-SM-46MVZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863972
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.38076
GSE205163,GSE205164_3_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.667884
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r4 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69371
membrane	LOCATE Curated Protein Localization Annotations	1.0	null
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KAT2A	ENCODE Transcription Factor Targets	1.0	null
layer 1 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32177
BACH1	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ATF3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r4BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69528
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.12957
hsa-miR-4692	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Pimozide_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0151614
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE171292_5_v_2_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RFX5	ENCODE Transcription Factor Targets	1.0	null
Retrosplenial area, lateral agranular part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85357
CHMP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47076
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BN-01B-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ppard_23093780_pancreatic_beta_cells_lof_mouse_gpl1261_gds4320	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.004641
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.19113
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.058
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.18204
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.43336
Perturb_3122_KO_Slc6a14_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.79588
VZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.863711
GSE135514_8_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PCNX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10032
Perturb_10615_OE|KO_Stk4|Lgals3_SRP121622	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.07642
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33359
heart_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.7162
lateral part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20501
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE118794_5_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
GABPA_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Allopurinol_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0311397
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.945886
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	1.0	2.50549
HT144	CCLE Cell Line Gene Expression Profiles	1.0	1.57586
CREB1-23762244-HIPPOCAMPUS-RAT	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.88447
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.779661
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.92814
Crizotinib (hydrochloride)_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.016182
H3K4me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
AZD1390_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0189696
SLC26A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17887
PUM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03467
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.89898
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.956
Verapamil_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0233175
RELA_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
amygdaloid complex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.995556
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IQ 1_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0260827
Lung adenocarcinoma_LUAD_TCGA-44-2662-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Dihydroartemisinin_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0322769
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.984388
hsa-miR-548ah	TargetScan Predicted Conserved microRNA Targets	1.0	0.212286
GTEX-XLM4-2026-SM-4AT4X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859393
MTA3	ENCODE Transcription Factor Targets	1.0	null
lateral group of nuclei, left, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.883427
Anteromedial visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19042
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184479_1_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854215
Adrenocortical carcinoma_ACC_TCGA-OR-A5JM-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Apalutamide_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0230576
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0326-SM-4BOP9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05954
Liver hepatocellular carcinoma_LIHC_TCGA-BC-4073-01B-02R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Posterior parietal association areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2853
Pancreatic adenocarcinoma_PAAD_TCGA-L1-A7W4-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEGF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14979
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38858
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03448
H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Belumosudil (mesylate)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0276483
hsa-miR-641	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE189609_1_v_2_hax1_human	RummaGEO Gene Perturbation Signatures	1.0	null
liminal part of the r9 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57065
GTEX-T2IS-2626-SM-32QPP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09345
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XUJ4-1126-SM-4BOPC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833013
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.392664
NFYA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WN-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.864584
TEX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9758
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.78445
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36368
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Pyridoxine_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0204621
H3K36me3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9415_KD_Mecom_SRP356893	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.77499
TFAP2A-17053090-MCF7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_10672_KO_Gata2_SRP212686	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.14881
Perturb_16632_Mut_Tardbp_SRP133158	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.76288
hsa-miR-4286	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65023
GSE211983_0_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.68413
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_upregulated-Ensembl_ID_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
ARHGAP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08826
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95849
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_SIN3A_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CAL-12T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0929
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_7_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GPX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02584
Perturb_5835_KO_miR144/451_SRP119158	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-13.1981
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.885256
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0426-SM-2XCF8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03446
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-D_ATF4-def_vs_HCT116_Tg2-Supplementary_Table_2D_Contrast_ATF4-def_Tg_2h_vs_HCT116Tg_2h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.82564
A-CA-04-2009(H1N1)_36Hour_None_GSE37571	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.66229
GSE129725_4_v_0_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WSUNHL	DepMap CRISPR Gene Dependency	1.0	2.32843
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46G-01A-31R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MK-8353_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0122685
gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.039738
GSE110248_1_v_6_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
medial mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1748
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.9219
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91405
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.70973
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal bone structure	GWASdb SNP-Phenotype Associations	1.0	0.198439
GATA1_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211128_2_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845105
H3K4me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A42K-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226114,GSE226116_2_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POU2F2	ENCODE Transcription Factor Targets	1.0	null
FAM175B	Pathway Commons Protein-Protein Interactions	1.0	null
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.192
EIF2B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66569
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59205
PRAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09364
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rosiglitazone_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0145459
CTCF	ENCODE Transcription Factor Targets	1.0	null
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5027-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28924
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE196699_7_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DLD1	DepMap CRISPR Gene Dependency	1.0	2.25799
GSE87404,GSE87812_1_v_3_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CF-91-JY05_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277657
Methylthiouracil_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0217731
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TET2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6715
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SHI1	DepMap CRISPR Gene Dependency	1.0	2.18502
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5240-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13217_KO_Mettl3_SRP109093	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.2202
GSE125153_2_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
paraterminal gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.841435
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13222_KO_Hdac3_ERP123505	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.15327
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.927332
MYC_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-519a	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
Fractures, Bone	CTD Gene-Disease Associations	1.0	2.88009
JB-75-NC66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23748
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.847371
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.70615
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA-42-YI34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229991
ELF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Amyotrophic lateral sclerosis type 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
GSE158834_1_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
WA-15-KX40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308249
hsa-miR-3942-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.212286
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.91738
Perturb_3370_KO_Zc3h12a_SRP183512	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.227
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17666_KO_Smad2/Smad3_SRP137054	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.86684
Penfluridol_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0276823
Osimertinib (mesylate)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00585112
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36606
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_ZFP42_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
MB-72-YK93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291767
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.0687
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4154-01A-01R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOS_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14515_KO_Esrrg_SRP331239	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.36037
MAX_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bone resorption disease	GWASdb SNP-Disease Associations	1.0	1.34719
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5466
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.16852
GTEX-WHWD-0326-SM-3LK6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10215
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.12845
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VZ in postamygdaloid region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16796
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.83023
Lung squamous cell carcinoma_LUSC_TCGA-21-1072-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R53T-0926-SM-3GADH	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01346
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5441-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE230744,GSE237803_0_v_2_hira_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0239577
Regorafenib_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0222792
doxorubicin_homo sapiens_gpl550_gds846	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
increased circulating triglyceride level	IMPC Knockout Mouse Phenotypes	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hippocampus (hippocampal formation)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10057
Rectum adenocarcinoma_READ_TCGA-AG-3591-01A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224297
BA-09-PG96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214379
SNU1_STOMACH	CCLE Cell Line Proteomics	1.0	3.00971
SMAD3-30307970-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
GSE218171_1_v_0_foxn3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Primary somatosensory area, trunk, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50076
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4224
PMC10794847-mmc2.xlsx-PBRM1_KD_up-Table_S1_Differentially_expressed_genes_with_PBRM1_knockdown_in_the_progenitor_state_Related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Berbamine (dihydrochloride)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0056157
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146074_9_v_11_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.22719
ATF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.906906
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE48812_9_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.949669
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03946
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EC-71-PH39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239349
SNU761	CCLE Cell Line Gene CNV Profiles	-1.0	-1.78288
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO 849	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11747
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1516
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211741
SA-03-IQ14_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323451
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMD8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45768
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QI-01A-11R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SYK_druginhibition_282_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.78997
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
orbital frontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03992
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.31777
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2B	ENCODE Transcription Factor Targets	1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01403
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15786
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23428
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.74277
PRKAG1	Pathway Commons Protein-Protein Interactions	1.0	null
interpositus (intermediate) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.39928
14695196-Table2	GeneSigDB Published Gene Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05946
Penfluridol_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0231248
NVP-BHG712_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0151918
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_1_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE255680_2_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
t56-vastus-lateralis_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.98099
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3R5-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_RCOR3_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PANC 03.27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.40536
hsa-miR-3115	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Brain Lower Grade Glioma_LGG_TCGA-CS-5394-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5583_NEDD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.551571
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7304
GSE169205_3_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.62191
Growth hormone receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.086
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NFYA	ENCODE Transcription Factor Targets	1.0	null
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.977002
SMC3	ENCODE Transcription Factor Targets	1.0	null
EGR1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-LC-A66R-01A-41R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6997_KO_Cap2_SRP182037	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.55045
Perturb_12073_KD_Tgfb1_SRP067296	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.80951
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257214
GTEX-WH7G-2326-SM-3NMBC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00415
H3K4me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A84J-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE89767_2_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE215314_0_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831536
CREB1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UA-39-TN76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.539584
SNU899	CCLE Cell Line Gene Expression Profiles	-1.0	-1.7438
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91399
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833539
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XGQ4-0226-SM-4GIDS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07124
5-Azacytidine_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0165766
Bone Mineral Density Test	DisGeNET Gene-Phenotype Associations	1.0	null
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09104
GSE169205_0_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54513
Macitentan_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0185719
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23108
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.32634
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AGO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75566
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.944712
BI-78D3_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0383122
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-XMD1-0011-R3B-SM-4AT5R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836486
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13448_OE|KD_PAX2|PTEN_SRP279768	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.5964
Perturb_1743_KO_U2af1_SRP297129	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.1748
GSE167956_1_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
Primary somatosensory area, barrel field, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.22282
Uridine_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0113764
MED9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18999
Perturb_18097_OE_Ogt_SRP214154	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.6224
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3591
Lung squamous cell carcinoma_LUSC_TCGA-85-8354-01A-31R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XMD1-0011-R2B-SM-4AT5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10093
layer 4 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36528
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PPIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14466
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WWYW-0926-SM-3NB2Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06444
FOXP2	ChEA Transcription Factor Targets	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.10166
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2577
H3K4me3_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CB-31-UO16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225877
Ventral pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00318
Brain Lower Grade Glioma_LGG_TCGA-P5-A77W-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EB-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12072_OE|KD_Tfap2a|Tgfb1_SRP067296	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.63148
XRK3F2_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0243367
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.914508
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATRFLOX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5973
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100478_HIP_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.90996
primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.97597
pparb_23093780_pancreas_lof_mouse_gpl1261_gds4320	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.004641
CREB1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE171572_0_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239844_6_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2834
A549_Gandotinib_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138782
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC25A11	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_3015_KD_SNHG1_SRP313438	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.979145
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04824
Lingula (I)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78031
Visual areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55491
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CG-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3145-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.843979
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4276	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Regorafenib_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0376368
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.86399
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.01002
Head and Neck squamous cell carcinoma_HNSC_TCGA-C9-A47Z-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WC-95-BX35_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22859
Tubulin inhibitor 6_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0199847
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06915
oculomotor nuclear complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.63761
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.30897
PDHA1	Pathway Commons Protein-Protein Interactions	1.0	null
TCCPAN2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45231
GSE105406_0_v_3_ptcd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ChIP_MYCN_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.683209
hsa-miR-1179	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Brivudine_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0256578
HDAC1	ENCODE Transcription Factor Targets	1.0	null
GTEX-XPVG-0726-SM-4B658	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876877
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840437
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
brownfat	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23583
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX3	ENCODE Transcription Factor Targets	1.0	null
Tomivosertib_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0329348
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YF-01A-12R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FS-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE137177_1_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BT483	CCLE Cell Line Gene Expression Profiles	-1.0	-2.37178
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EX-01A-12R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K14ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE228106_0_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Femoral neck bone mineral density	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.730103
GSE212486,GSE212488_2_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.862741
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver enzyme levels (alkaline phosphatase)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.2699
Auranofin_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0238105
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_3379_KO_Pgd_SRP309436	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-13.5529
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Trametinib (DMSO_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0283827
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE117730,GSE117732_0_v_2_apobec2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5640240-ppat.1006668.s013.xlsx-MAX_ChIP_shEP400-1-Unnamed_6_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
TCF12	ENCODE Transcription Factor Targets	1.0	null
ccnd1_18413728_imr_neuroblastoma_lof_human_gpl570_gse8866	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.927912
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44362
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.33444
Nucleus ambiguus, dorsal division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44727
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XK95-0426-SM-4AT4R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18762
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02857
CHD7	ENCODE Transcription Factor Targets	1.0	null
GSE242367_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.018
Acute Myeloid Leukemia_LAML_TCGA-AB-2849-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAL1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
NCIH2196	CCLE Cell Line Gene CNV Profiles	1.0	1.35266
GSE211983_1_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8494348-pone.0257161.s002.xlsx-only_D20_-_OXT_NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51127
pineal_night	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.898868
CHD4	ENCODE Transcription Factor Targets	1.0	null
CADOES1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.524
GT3TKB	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
GTEX-SUCS-0326-SM-32PLL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85576
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perindopril (erbumine)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0308506
PMC8405683-41419_2021_4120_MOESM2_ESM.xlsx-Sheet1-Table_S2_MYCN-responsive_gene_list_1_5_fold_p_0_05_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NL3H-0011-R4a-SM-2I3GK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916506
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
icSARS CoV_12Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.873131
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3306-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228106_3_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77926
GSE150557_1_v_0_dnmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PLK1	Pathway Commons Protein-Protein Interactions	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19909
Omeprazole_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.025437
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.532574
MKN74	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69332
Tofacitinib_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0240465
20371479-TableS2	GeneSigDB Published Gene Signatures	1.0	null
Regorafenib_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0116173
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-6672-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.946328
GSE88819_6_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1359	CCLE Cell Line Gene Expression Profiles	1.0	1.78568
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4P3-0626-SM-4AD59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14035
CTCF_mammary epithelial cell_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA-58-FJ71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2795
Perturb_17683_KO_Parp1/Parp2_SRP311978	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.57786
Perturb_10718_KO_Hck_SRP340501	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.48489
Orlistat_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0251966
TRIM28_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE154219_0_v_2_cholestyramine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152804
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD19 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.12238
H3K4me1_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S3XE-0426-SM-3K2AC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0383
DD-74-PJ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241908
Medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20501
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.86744
DMS-53	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.51019
Finasteride_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0410737
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4848
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GSE180147_0_v_1_itga5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Vandetanib_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0214279
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H2BK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FLI1_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MELK	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38782
ETS1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HL-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32807
GE-40-GQ38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275705
Dimethyl fumarate_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.035892
GSE146074_9_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-3783-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
musculoskeletal system disease	GWASdb SNP-Disease Associations	1.0	0.119548
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9937
Perturb_13108_KO_Mbnl1/Mbnl2_SRP045573	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.74193
TEAD4_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DEOC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30705
GTEX-U4B1-0326-SM-3DB8K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08531
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.19909
BFTC-909	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.908331
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Quinestrol_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0132399
hsa-miR-582-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1208
NCIH1341	CCLE Cell Line Gene Expression Profiles	-1.0	-1.99672
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.74277
Flumatinib (mesylate)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0477921
PMC9218734-Supplementary_Data3.xlsx-KRIEG-KRIEG_HYPOXIA_NOT_VIA_KDM3A_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
SIX5	ENCODE Transcription Factor Targets	1.0	null
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.88379
ChIP_ZFX_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Perturb_3364_KO_Adora2a_SRP306572	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.88596
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.582304
GSE183413_1_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.030135
K562_Tubastatin A HCl_10µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148139
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
KB-77-BA46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262475
MC116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16544
CFPAC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.76817
NCIH146	CCLE Cell Line Gene CNV Profiles	1.0	1.34971
Frontal pole, cerebral cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38937
r10 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.97239
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.76304
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.533915
increased circulating triglyceride level	MGI Mouse Phenotype Associations 2023	1.0	null
increased osteoclast cell number	MGI Mouse Phenotype Associations 2023	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
Primary somatosensory area, barrel field	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25929
NSF	Pathway Commons Protein-Protein Interactions	1.0	null
GSE135030_8_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-21-FY25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222247
Perturb_7083_KO_Jmjd4_SRP393926	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.33423
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
537 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14006
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.932221
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.25448
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.89409
HCT15	DepMap CRISPR Gene Dependency	1.0	2.28961
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SJXC-0526-SM-2XCFG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24781
Brain Lower Grade Glioma_LGG_TCGA-CS-4938-01B-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206729_2_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JUND_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRF	ChEA Transcription Factor Targets	1.0	null
Perturb_3135_KO_Sox5/Sox6_SRP045626	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.31261
GSE44157,GSE44163_1_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H4K91ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
u138mg	HPA Cell Line Gene Expression Profiles	1.0	1.9515
GSE239844_6_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XMD1-0011-R1A-SM-4AT4C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850077
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07624
Brain Lower Grade Glioma_LGG_TCGA-DU-8165-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
Secondary motor area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04379
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.52833
GSE178340_5_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.53611
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X62O-2226-SM-46MW3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00151
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.712856
GSE179974_3_v_5_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187307
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4160-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary motor area, Layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16219
GTEX-PWN1-0008-SM-48TEA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837564
Primary visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.08136
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05116
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
QF-00-NO42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.451849
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.86957
GSE211983_1_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
496100431_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.26331
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.12997
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_15607_KO_Dnmt1_SRP247926	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.8473
AB-17-WP43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224485
MF-11-EW49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252559
Perturb_16993_KO_Srsf1_SRP371030	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.31166
Primary somatosensory area, upper limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15981
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
GSE100528_1_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153189_2_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
FZD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40016
H2AC21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06874
SKMEL1	CCLE Cell Line Gene Expression Profiles	1.0	2.62819
intermediate stratum of r10BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28338
Abiraterone acetate_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.021012
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18062
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26837
PMC5263239-mmc2.xls-THP-1_-_MLL-AF9-Non-spreading_targets_gene_names_1900_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_GSK J1_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131396
Acute Myeloid Leukemia_LAML_TCGA-AB-2819-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K36me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-OOBJ-0008-SM-3NB26	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979745
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13032
CF-82-LL11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.400184
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3096
Lidocaine (hydrochloride)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0149499
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO800	CCLE Cell Line Gene Expression Profiles	1.0	1.72082
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU2F2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r10 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46712
Erythromycin_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0266614
Entorhinal area, lateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18007
Perturb_12319_KD_PRMT1_SRP165280	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.499882
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.05499
H3K9ac_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
Perturb_10716_KO_Mtx2_SRP404364	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.24472
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Vertebral endplate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.646
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9777_KO_Mettl6_ERP120512	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.8936
MAX	ENCODE Transcription Factor Targets	1.0	null
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_3_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.833304
DB-01-BR68_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259045
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.83921
EP300	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5066-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1493
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.13616
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SETDB1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.864842
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-C_ATF4-def_vs_HCT116_DMSO8-Supplementary_Table_2C_Contrast_ATF4-def_DMSO_8h_vs_HCT116_DMSO_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324184
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
Retrosplenial area, lateral agranular part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52788
Astrocytoma_CNS - Brain (MMHCC)_GSE4290	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.30143
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.52995
embryonic lethality prior to tooth bud stage	IMPC Knockout Mouse Phenotypes	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4635-01A-02R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NL3H-0011-R7a-SM-2I3G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993706
Perturb_12697_KO_Ezh2_SRP222765	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.53241
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC827GR5	DepMap CRISPR Gene Dependency	1.0	2.1515
hela	HPA Cell Line Gene Expression Profiles	-1.0	-0.870087
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10765
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07028
H3K23me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Arbutin_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0296854
hsa-miR-590-3p	MiRTarBase microRNA Targets	1.0	null
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905393
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.17932
Bestatin_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0350117
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TRPM7_overexpression_305_GSE23102	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.33681
ZNF354A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47916
Perturb_17401_KD_HMGCR_SRP216293	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.51057
SK-MEL-24	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.38278
H3K27ac_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NA-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RERFLCAI	CCLE Cell Line Gene CNV Profiles	1.0	2.20595
Homoharringtonine_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0157815
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE145311_0_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
embryonic lethality prior to organogenesis	IMPC Knockout Mouse Phenotypes	1.0	null
Apalutamide_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0168996
hsa-miR-548j	TargetScan Predicted Conserved microRNA Targets	1.0	0.111118
GSE159084_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969638
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29N-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228263_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_11_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Furosemide_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0189191
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.0675
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T6MN-0126-SM-32PLP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03791
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11A-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CREB1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5470_NAT10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.19205
Perturb_3081_KO_Dock11_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.791
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AH-0526-SM-2I3ED	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839481
Rifaximin_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0140026
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 800	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.42107
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IM-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-3.34668
mbl2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.75
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.93807
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-17	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
SNU899	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49831
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987023
VZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.859038
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6950-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4125
MELHO	CCLE Cell Line Gene Expression Profiles	1.0	1.45266
888	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24432
layer 5 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19162
Perturb_11469_KD_HRP2_SRP305641	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.61139
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114232_10_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
BICR31	CCLE Cell Line Gene CNV Profiles	-1.0	-2.21979
YY1	ENCODE Transcription Factor Targets	1.0	null
GSE81193_0_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE198165,GSE198166_7_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GD-51-SU60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284414
GSE100732,GSE100733_0_v_1_lrpprc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LJI308_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00378921
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228106_0_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49946
GSE204929_0_v_1_ywhag_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bosentan (hydrate)_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0270477
GSE149075_8_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Posterior parietal association areas, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37227
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Topotecan (hydrochloride)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0237328
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.89017
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K14ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7X1-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE149901_3_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9702_KO_Mef2a_ERP122655	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	15.0939
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.35552
GATA2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902247
RELA	ENCODE Transcription Factor Targets	1.0	null
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5-Fluorouracil_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0249818
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.21203
GSE139239_2_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166783_0_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Temporal association areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85598
USF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20068
GMPS	Pathway Commons Protein-Protein Interactions	1.0	null
COR-L105	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.01197
AD-86-OB87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208401
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MZ in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02618
USF1_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GB-57-XV52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210461
decreased bone mineral density	MGI Mouse Phenotype Associations 2023	1.0	null
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.031912
GSE158197_6_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BICR31	CCLE Cell Line Gene Expression Profiles	-1.0	-1.5631
GTEX-O5YT-0326-SM-32PKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62071
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351241
MYB-21317192-ERMYB-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3N5-01A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE196962_2_v_1_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.32712
hsa-miR-621	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
Acetazolamide_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0192751
hsa-miR-150	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Ligustrazine_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0476634
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Chondrocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.075
NUP93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3102
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A118-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
u2197	HPA Cell Line Gene Expression Profiles	1.0	0.915584
NFIC	ENCODE Transcription Factor Targets	1.0	null
GTEX-XXEK-0926-SM-4BRWH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11736
SEMA3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18844
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41863
EP300_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3608
E2F6	ENCODE Transcription Factor Targets	1.0	null
GTF2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE164757,GSE164759_1_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CREB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EA-95-YQ95_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236394
GTEX-WFG7-0426-SM-4LMK5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98461
MYC	ENCODE Transcription Factor Targets	1.0	null
Perturb_15689_KO_Rela_SRP075924	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.87064
PMC9170756-mmc6.xlsx-P6-Table_S3_The_JUN-targeted_responders_to_FFA_treatments_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CK-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NA-A4R1-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE235516_0_v_1_zdhhc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20231
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WZTO-1326-SM-3NM8X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4544
GTEX-WI4N-1126-SM-3LK7Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12027
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3313-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE235390_4_v_2_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315384
POLR2A_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DA-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Serum alkaline phosphatase levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
Nafamostat (mesylate)_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.012726
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Regorafenib_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0222124
Primary visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.40857
Perturb_7938_KO_MED24_SRP201365	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.14892
parietal cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14112
Lung adenocarcinoma_LUAD_TCGA-55-7726-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HI-7171-01A-12R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE136232,GSE136234_0_v_1_zpbp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE249098_1_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	1.0	null
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324751
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.10213
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54364
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R45C-0008-SM-48FF2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862533
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
537 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02273
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-2.04542
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-93-A4JP-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE205729,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.71145
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67413
GTEX-XQ8I-0226-SM-4BOPM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996505
H3K9ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE114232_8_v_6_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31319
GSE158197_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sapanisertib_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0156909
ATF3_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Plicamycin_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0406137
head of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01795
GTEX-WH7G-0326-SM-3NMBH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26889
Primary somatosensory area, lower limb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00867
Prostate adenocarcinoma_PRAD_TCGA-EJ-5495-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208188
GTEX-U8T8-2226-SM-3DB95	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15952
KB-92-MK13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314308
Perturb_9776_KO_Mettl6_ERP120512	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.4761
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840437
GSE149035_2_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5783
PMC7338542-41389_2020_247_MOESM6_ESM.xlsx-BRN2_2_of_3_DOWN_48_h-Symbol_POU3F2	Rummagene Transcription Factor Associations 2026	1.0	null
CAL12T	CCLE Cell Line Gene CNV Profiles	-1.0	-2.10932
Lung squamous cell carcinoma_LUSC_TCGA-90-7769-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43425
MYC	ChEA Transcription Factor Targets	1.0	null
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21758
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.60618
GTEX-XUW1-1726-SM-4BOOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35202
PML	ENCODE Transcription Factor Targets	1.0	null
GSE182680,GSE182683_10_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TIRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6991
MYC-19030024-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
TC-66-CI47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.414097
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04754
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847263
GSE166944_0_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nimesulide_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0238606
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15006
GTEX-UJHI-0626-SM-3DB8T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.904732
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.43486
r1 part of vestibular nucleus Y	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05301
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.541837
Loperamide (hydrochloride)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0412919
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80574
GSE198165,GSE198166_8_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.018
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37227
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Infigratinib_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0224553
rhombomere 11	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08289
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0008-SM-48TDW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876236
Rucaparib (phosphate)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0274139
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.990152
Glasdegib_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0221588
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A497-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZFX	ChEA Transcription Factor Targets	1.0	null
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.74615
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Plicamycin_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0144322
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.61827
GTEX-R55G-2326-SM-2TC61	GTEx Tissue Sample Gene Expression Profiles	1.0	2.17334
Bosentan (hydrate)_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0113077
SCAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19314
NC-27-AD53_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.541117
Ponatinib_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0333362
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.66393
GTEX-OOBJ-0326-SM-33HBO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924484
GSE216538_0_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XOTO-0011-R6B-SM-4B65X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905862
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02384
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.89173
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05684
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
VHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34366
H3K4me3_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE157594_6_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.006598
THAP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29Q-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE210770_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242647_2_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MEX3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13184
Tasimelteon	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE127261_1_v_2_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149355_0_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DT-061_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0358728
abnormality of bone mineral density	GWASdb SNP-Phenotype Associations	1.0	1.1784
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6475
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1822_KO_Irf5_SRP233379	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.09267
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8982
periventricular stratum of r5Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60413
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE150669_0_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.26041
TA-57-FF07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303908
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PLZ6-0726-SM-3P619	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15496
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12744
GSE220914_2_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_9416_KD_Mecom_SRP356893	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-15.5211
Ciclopirox_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0245504
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Table_S5C_Downregulated_genes_in_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_mammary_fat_pad_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GSE230329_0_v_3_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2622_EMG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.748423
hsa-miR-3146	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MARVELD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17303
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.832589
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.458989
HCC4006	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.92188
NANOG	ChEA Transcription Factor Targets	1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87954
hsa-miR-1229	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
hsa-miR-449c	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360093
NCIH1155	DepMap CRISPR Gene Dependency	1.0	2.1693
hsa-miR-623	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Frontal pole, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38236
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EF-01A-12R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146074_0_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
orbital frontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.89898
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6429
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2ES-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACSM2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57809
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7441006-41388_2020_1389_MOESM2_ESM.xlsx-Supplementary_Table_1-Prostate-Specific_MYC_Overexpression_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13492
Lung adenocarcinoma_LUAD_TCGA-69-8255-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QEG5-1126-SM-33HC2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00402
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.35946
SK-GT-2	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.03674
Primary somatosensory area, unassigned	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1783
H3K27ac_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_Ofloxacin_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131087
Lung adenocarcinoma_LUAD_TCGA-05-4390-01A-02R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CC-70-BD07_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299707
FD-59-TC81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207135
K562_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156562
GSE248858_6_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-5247-01A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_ZR75_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Bulbourethral gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.797
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRCA1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4415-01A-22R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAK-733_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0170684
GSE166536_1_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	1.0	3.51704
FAM110D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43279
GSE255432_4_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	3.72599
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218895
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ivermectin_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0201089
FOXO3	ChEA Transcription Factor Targets	1.0	null
Harringtonine_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0204434
Rifaximin_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0377763
Kidney Chromophobe_KICH_TCGA-KL-8332-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE239688_4_v_0_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cloxacillin (sodium)_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0200709
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.87023
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4959-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1924
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A5DX-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178255_3_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55G-0326-SM-48FDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876585
Glycyrrhizic acid_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.034854
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Ataluren_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0243105
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217405_3_v_2_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3644282-1471-2164-14-110-S3.xls-Contextual_Gene_Set_TCGA-GBM-OVOL2_OVOL2	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4730-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE137702_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
Edoxaban (tosylate monohydrate)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0183392
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-5775-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
496100462_PCx_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.12279
PMC4051124-1471-2164-15-256-S15.XLSX-WES_IPD-RBCK1_1-Target_RBCK1	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7010-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YV-0326-SM-2I5H2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15604
hsa-miR-3065-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	1.36575
ARF4	Pathway Commons Protein-Protein Interactions	1.0	null
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.438544
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
ATAD3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28808
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15631
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE235390_4_v_0_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
testis_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.00142
Primary somatosensory area, upper limb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01699
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4789-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8130-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.2849
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13429
hsa-miR-4275	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.83638
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.29933
adrenalgland	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.01531
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.896551
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47292
mediodorsal nucleus of thalamus_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.36185
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUJ4-0526-SM-4BOON	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05683
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-513a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.004732
Emery-Dreifuss muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
Pemetrexed_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0222641
Triclosan_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0237132
substantia nigra, pars compacta, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.29695
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CF-61-EH59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272835
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80V-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9634663-DataSheet10.xlsx-K562-MYC-AID_RNA-Seq_1326_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73329
GTEX-OXRL-1826-SM-2YUMV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925195
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11504
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.596283
KM12	DepMap CRISPR Gene Dependency	1.0	2.10046
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.13231
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAL1	ChEA Transcription Factor Targets	1.0	null
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.30954
AF-99-HA02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.614625
RAP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07173
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64905
ROCK_INHIBITION_GDS3944_461_mouse_Forebrain astrocytes - 2 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227034
Perturb_12792_KO_Tgfbr2_SRP133892	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Roxadustat_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0345824
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LNZ308	DepMap CRISPR Gene Dependency	1.0	2.03287
caudal group of intralaminar nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02178
superficial stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04654
SOX2_Deficiency_GDS4853_321_human_AZ-521 gastric cancer (GC) cell line - 18 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37862
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Supplementary_Table_2B_Contrast_ATF4-def_DMSO_2h_vs_HCT116_DMSO_2h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9417_KD_Mecom_SRP356893	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.93848
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SP1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3K_Peaks_wtYAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18036
Perturb_6492_KO_Atrx_SRP323952	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-17.3947
GSE88819_11_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KM12	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45645
Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EA-84-SC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.393134
medial geniculate complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.919123
GSE221577_2_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
isoproterenol hydrochloride_rattus norvegicus_gpl1355_gse7999	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.44335
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
golgi apparatus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sildenafil_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0309126
Osimertinib (mesylate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0198928
mantle zone of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56824
hippocampus (hippocampal formation)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08363
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE192513,GSE192515_1_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Peretinoin_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0359942
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Calcific aortic valve stenosis	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.522185
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.786615
GSE101112_0_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE130437_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
mantle zone of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.73562
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.76162
hsa-miR-4252	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE148066,GSE157787_5_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GATA1	ENCODE Transcription Factor Targets	1.0	null
NCIH647	DepMap CRISPR Gene Dependency	1.0	2.23383
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29338
GSE200352_10_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.878421
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-548a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.154935
substantia nigra reticulata, isthmic part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34183
GTEX-UJHI-0426-SM-3DB8Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3992
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.40127
PK-45H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.866769
2125_DDX49_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.36624
Brimonidine_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.028736
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.99464
Lung adenocarcinoma_LUAD_TCGA-78-7542-01A-21R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
Gefitinib_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0218924
posteromedial visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20218
Kidney Chromophobe_KICH_TCGA-KN-8422-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DE-99-OT37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261886
nucleus of Darkschewitsch, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1704
GTEX-SUCS-1426-SM-4DM5W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1647
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU283	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45608
Perturb_5351_KO_Dux_SRP201141	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.99067
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11192
E2F6_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nes	HPA Cell Line Gene Expression Profiles	-1.0	-1.30296
G361	CCLE Cell Line Gene Expression Profiles	1.0	1.61608
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41598
Perturb_15270_KO_Bap1_SRP162522	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-19.3979
Meloxicam_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0252462
H3K4me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Integral component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.935
MAX_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.966284
FBXO27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22924
496100333_FWM_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.68539
1040_C1ORF131_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.745443
NCI-H1650	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.26189
RA-81-JZ66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247262
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.963647
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.531889
Methylthiouracil_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00721825
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GD-51-SU60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.342507
lateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02002
RL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5143
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
UA-39-TN76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245682
Posterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79257
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-61-UO01_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293335
GSE154253_1_v_0_tnfaip8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ADRA2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35329
GSE199606_5_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_16665_KO_Slc27a2_SRP186493	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.62281
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07935
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim22_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CREB1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154822
MCAS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.57578
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3613-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
Brain Lower Grade Glioma_LGG_TCGA-QH-A65R-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CUX1	ENCODE Transcription Factor Targets	1.0	null
Belinostat_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0167235
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RM-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE206226_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6080909-JEM_20171312_TableS1.xlsx-miR-196_predicted-Table_S1_miR-196a_b_predicted_targets_by_PITA_PicTar_TargetScan_and_DIANA_prediction_algorithms_ZFP1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DU4475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.964725
nucleus incertus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08467
RANGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vinblastine (sulfate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0162363
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38111
primary auditory cortex (core)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.899224
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25725
GSE205163,GSE205164_2_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8141032-NIHMS1694738-supplement-Supplementary_Table_1.xls-MYC_BAF155_BRG1-Unnamed_14_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Anterolateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56795
NELFE	ENCODE Transcription Factor Targets	1.0	null
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.70935
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fulvestrant_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0151141
Demeclocycline_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0138959
hsa-miR-3923	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
ATAD3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02436
C-28/I2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.714
Lopinavir_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0113885
Bosentan (hydrate)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0461421
PMC11611169-pone.0314092.s001.docx-3-PPARG_PPARG	Rummagene Transcription Factor Associations 2026	1.0	null
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.01663
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98495
GSE111385_2_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Saquinavir_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.041372
Elf5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.4172
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.73914
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.66889
superficial stratum of r7Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26593
SYK_druginhibition_284_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.60757
Acquired Immunodeficiency Syndrome	HuGE Navigator Gene-Phenotype Associations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4075-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.8048
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40009
DIS3	Pathway Commons Protein-Protein Interactions	1.0	null
TE-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
GSE199204,GSE211619_4_v_2_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFRKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01505
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.46992
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2721
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11725
MYC_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16370_KO_p110alpha_SRP174500	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.54796
6611_PPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.690387
Hexylresorcinol_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0337087
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5113908-pone.0166185.s004.xlsx-Supp_1-Supplementary_Table_1_mRNA_expression_correlates_with_STAT3_phosphorylation_for_1279_genes_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
AC-80-DI95_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208024
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.399635
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UJMC-0526-SM-3GAE3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23123
SNU-601	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.908331
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
FAM175A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE182680,GSE182683_5_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VMRCLCD	DepMap CRISPR Gene Dependency	1.0	2.40995
ELF1	ENCODE Transcription Factor Targets	1.0	null
Nimesulide_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0134273
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A42F-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF157	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97018
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPM-1026-SM-3LK74	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12759
GTEX-WEY5-0226-SM-3GIKN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47369
RPL13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40866
Entecavir (monohydrate)_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.030915
FOXA1	ENCODE Transcription Factor Targets	1.0	null
NCIH1869	DepMap CRISPR Gene Dependency	1.0	2.34372
GSE129725_1_v_5_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IPC-298	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.50008
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19528
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351189
Bimatoprost_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0149322
r10 part of basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.06875
Adrenocortical carcinoma_ACC_TCGA-OR-A5K3-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
peripheral portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16394
mantle zone of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33138
GPT2	Pathway Commons Protein-Protein Interactions	1.0	null
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.15257
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.360606
GTEX-U8XE-2526-SM-4E3IT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862978
GSE48812_2_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-4263	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Fingolimod (hydrochloride)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0398799
ZBTB33_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Darolutamide_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0188784
HCA1	DepMap CRISPR Gene Dependency	1.0	2.06501
FOXO3-22982991-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HOP-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37862
GSE168918_1_v_0_tmprss4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Voriconazole_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0274056
lateral part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.06875
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
GSE247862,GSE247863_0_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.37301
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.32724
Primary somatosensory area, trunk, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35307
TNKS	Pathway Commons Protein-Protein Interactions	1.0	null
Mitochondrial ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.114
NFE2	ENCODE Transcription Factor Targets	1.0	null
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840437
dorsolateral prefrontal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.940082
GSE125007,GSE125008_4_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_17415_OE_Gata3_SRP150425	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.9331
GSE146074_1_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4803	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-B_ATF4-def_vs_HCT116_DMSO2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
AK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27048
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07481
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.02834
BEN	CCLE Cell Line Gene Expression Profiles	-1.0	-2.9237
tail of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.28758
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-519b-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
Lung squamous cell carcinoma_LUSC_TCGA-56-5898-01A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_8713_KD_Stat5_SRP111924	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.7371
BAIAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31544
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8XE-1826-SM-4E3HV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10823
H3K56ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE155972_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
HCT 116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
JUN_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PSDG-1126-SM-2S1ON	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14457
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8141032-NIHMS1694738-supplement-Supplementary_Table_1.xls-MYC_BAF155_BRG1-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233049_1_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1191
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09433
AA-86-YY62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.347101
SIN3A_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1	ChEA Transcription Factor Targets	1.0	null
GSE125007,GSE125008_1_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287672
GSE220520_1_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BA-68-FJ41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262236
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.3145
medial part of r5B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04771
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89141
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24607
UBB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29773
H2BK20ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_3835_KD_RNPK_SRP342664	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
primary auditory cortex (core)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06465
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZFX-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.990363
EHF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1562
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12976
H3K9ac_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.467981
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35023
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51116
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2553_EIF3I_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50871
Bosentan (hydrate)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0177776
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5228
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95421
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D3REFED24h_1198_AR-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160817_5_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Bone resorption disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.668
Loperamide (hydrochloride)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0216124
hsa-miR-3166	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Perturb_7124_KO_Prkcd/Prkce_SRP049245	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.11254
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.49723
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-20b	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OHPN-0011-R1A-SM-2I5GB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03467
midbrain raphe nuclei	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.3094
Erdafitinib _C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.016123
Prostate adenocarcinoma_PRAD_TCGA-G9-7521-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
increased mean corpuscular volume	IMPC Knockout Mouse Phenotypes	1.0	null
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
JHOS-2	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.93357
BTF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5642
H3K27ac_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.660396
Perturb_12052_KD_Tgfb1_SRP067296	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.10767
BACH1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193993_5_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_16770_KO_Lrch1_SRP261798	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.02156
GABP-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-0626-SM-4BOOB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47122
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2363
Kidney Chromophobe_KICH_TCGA-KL-8337-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Vertebra	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.457
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PSDG-1026-SM-48TCV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07422
r9 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1225
H3K9ac_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
r8 part of inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03503
GTEX-RNOR-0826-SM-2TF5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00898
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
MRPS15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05975
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.52467
H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.4189
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.95633
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12744
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.320634
superficial stratum of PCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14054
GTEX-XQ3S-0126-SM-4BOO9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875593
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19373
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
creb1_22108299_heart_left_ventricle_lof_mouse_gpl1261_gds3660	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.822104
MYC_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52584
Perturb_5292_KO_Dgcr8_SRP137730	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.56499
EB-09-OC36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201998
SFXN4	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.963647
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 2 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.80373
Lung adenocarcinoma_LUAD_TCGA-38-4631-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.847163
GSE178340_5_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.4208
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.29238
PRDM14	ChEA Transcription Factor Targets	1.0	null
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45415
Capmatinib_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0309787
WC-09-GD62_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.614418
A549_UNC1999_1µM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128796
Primary somatosensory area, barrel field, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37147
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRCA1	ENCODE Transcription Factor Targets	1.0	null
r4 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62146
Parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.39026
KLF4-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.70392
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-7980-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB7A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_ZM 447439_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151869
GSE164757,GSE164759_1_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Tirabrutinib (hydrochloride)_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0182063
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE126127_2_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02728
SIN3A_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26698
ETS1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BL-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-106b	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
ABL1_mutant_24_GDS4046	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.38526
Medullary reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08834
SRF	ENCODE Transcription Factor Targets	1.0	null
pituitary	GTEx Tissue Gene Expression Profiles	-1.0	-0.833692
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874826
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06934
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-1273g	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3K_Peaks_wtYAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28821
mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bentamapimod_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0199709
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25822
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.58959
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE203158_0_v_13_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAX	JASPAR Predicted Transcription Factor Targets	1.0	null
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
WM-266-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.22108
lingual gyrus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.827757
superficial stratum of isBI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33977
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO205	DepMap CRISPR Gene Dependency	1.0	2.28558
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anteromedial visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33727
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE179002_4_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MICOS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.564
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE136627_2_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H2228	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02298
GTEX-TSE9-2826-SM-4DXTF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837287
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02441
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3RC-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XXEK-2026-SM-4BRVE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875964
USF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-0426-SM-3GIKT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23375
Lung adenocarcinoma_LUAD_TCGA-91-8499-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.45552
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.636703
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Q-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.45265
hsa-miR-4778-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRI3BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54581
Rectum adenocarcinoma_READ_TCGA-DC-6682-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K18ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
Vinblastine (sulfate)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0421503
PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
hek293	HPA Cell Line Gene Expression Profiles	-1.0	-1.19862
NCI-H2369	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.897654
hsa-miR-4678	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of r10Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66949
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.517347
TFAP2A	ChEA Transcription Factor Targets	1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ivabradine (hydrochloride)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0298381
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r3 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10446
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21959
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cortico-medial group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20682
Perturb_14565_KO_Got2_SRP348541	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.67513
tcf12_20154672_cd4pos_cd8pos_thymocytes_thymus_lof_mouse_gpl6246_gse19923	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.068768
WA-15-KX40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.455292
AC-49-NG46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213376
Relugolix_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0361944
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941433
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22498
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Dilated cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
medial part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7384
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
SKPNDW	DepMap CRISPR Gene Dependency	1.0	2.21401
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316056
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
RERF-LC-MS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.95633
Lung adenocarcinoma_LUAD_TCGA-64-1676-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-LT-A5Z6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16547_KO_Dusp6_SRP322434	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.9703
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPN-0226-SM-48TBV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947563
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1503
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1299	CCLE Cell Line Gene CNV Profiles	1.0	1.53872
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
IE-38-FB31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376214
GTEX-OHPK-1826-SM-2YUMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.968303
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-RP-A693-06A-13R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDVN-0926-SM-2I5GL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06964
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JI-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-548h	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE195663_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2747_ESYT1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.686836
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MYB	ChEA Transcription Factor Targets	1.0	null
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FF-90-JK74_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268864
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25714
Domain of unknown function DUF1279	InterPro Predicted Protein Domain Annotations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5882-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182835,GSE182836_0_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OHPM-0326-SM-33HCA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07253
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R53T-0005-SM-3GADK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04688
GSE48812_7_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-84-QG99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.94967
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7595-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMARCB1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Epirubicin (hydrochloride)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0272208
Penfluridol_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0125671
GSE215086_3_v_7_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02155
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PM-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXP2	ENCODE Transcription Factor Targets	1.0	null
GTEX-P4QS-1026-SM-3NMCW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.968423
GSE217694_3_v_2_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07608
Somatosensory areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08433
IRF4	ENCODE Transcription Factor Targets	1.0	null
TCF12_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU7-0426-SM-2XCDX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885799
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995738
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IC-05-AW29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.677092
GTEX-OIZI-0126-SM-3NB13	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961637
outer SZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.52713
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.96897
GSE114258_3_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
liver	GTEx Tissue Gene Expression Profiles	1.0	0.98166
ATF3	ENCODE Transcription Factor Targets	1.0	null
NFATC1	ENCODE Transcription Factor Targets	1.0	null
PML_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DMS153	CCLE Cell Line Gene Expression Profiles	-1.0	-2.33727
GSE217363_4_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
decreased compact bone thickness	MGI Mouse Phenotype Associations 2023	1.0	null
UA-39-TN76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307421
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.36937
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6917-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
kidney	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.00747
A549_Amisulpride_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150228
MDAMB468	CCLE Cell Line Gene CNV Profiles	1.0	1.62902
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51174
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Q-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Crizotinib (hydrochloride)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0192988
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.51269
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.018
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GZ-05A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I1-06A-12R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K18ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCIH810	CCLE Cell Line Gene Expression Profiles	-1.0	-1.81976
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vitamin K4_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00582588
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24049
GSE149124,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Posterolateral visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.5627
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.61221
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06162
MAX_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26995
GTEX-S95S-0726-SM-4B64H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04751
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.66585
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59762
HC-76-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.460701
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Trametinib (DMSO_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0136677
BF-02-AC35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.532277
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29186
ARHGEF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83442
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GCIY	DepMap CRISPR Gene Dependency	1.0	2.09487
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08691
Glycyrrhizic acid_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0179821
Nucleus y	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01293
ZBTB7A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-548w	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.853567
Epirubicin (hydrochloride)_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0234706
Primary somatosensory area, upper limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16161
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Perturb_11255_KO_Nr5a2_SRP131036	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.84606
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270264
lateral hypothalamic area, mammillary region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.860587
K562_PD173074_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196083
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75387
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6335
MELJUSO	CCLE Cell Line Gene Expression Profiles	1.0	2.07801
r10 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42794
ZFP42	ChEA Transcription Factor Targets	1.0	null
WM983B	CCLE Cell Line Gene Expression Profiles	1.0	1.37944
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_7096_KO_Eif2ak3_SRP271084	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.05149
GSE152734,GSE152735_1_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12744
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.90002
17616640-TableS3	GeneSigDB Published Gene Signatures	1.0	null
nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.53726
Lung adenocarcinoma_LUAD_TCGA-78-8662-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE255432_7_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.294
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_2_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nodulus (X), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13334
MORCPR	CCLE Cell Line Gene Expression Profiles	-1.0	-2.54221
GSE149124,GSE149128_2_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HDQP1	CCLE Cell Line Gene CNV Profiles	1.0	2.79199
TC106	DepMap CRISPR Gene Dependency	1.0	2.01169
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.3736
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5724
UBTF	ENCODE Transcription Factor Targets	1.0	null
GTEX-R3RS-0008-SM-48FF1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14447
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982497
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_16855_KO_Hnrnph1_SRP068520	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.93598
SNU869	DepMap CRISPR Gene Dependency	1.0	2.2207
hsa-miR-4672	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE134515_1_v_2_sh2d2a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20964
POLR2A_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.872269
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114690_2_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12729234-10194_2025_2222_MOESM1_ESM.xlsx-Table_S3-Table_S3_MR_results_of_the_586_significant_genes_from_TG_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29808
outer CP in (rostral) midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.93011
Inflammation	CTD Gene-Disease Associations	1.0	1.50043
GSE48812_4_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE189609_1_v_0_hax1_human	RummaGEO Gene Perturbation Signatures	1.0	null
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12628
FLI1	ENCODE Transcription Factor Targets	1.0	null
GB-84-KP45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238822
GSE94011_0_v_3_pias3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE209938_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nucleus ambiguus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42367
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JHH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10212
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.698539
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.07844
occipital cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32991
PMC11563688-jci-134-173448-s017.xlsx-EC2-gene_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56577
HMGN3	ENCODE Transcription Factor Targets	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AR-27623747-22RV1-MOUSE-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
Diphenhydramine_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0167177
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-0826-SM-3GIKU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38883
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, trunk, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43106
GTEX-QV44-0526-SM-2S1RE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68293
FOXO3-22982991-MACROPHAGES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-F_ATF4-def_vs_HCT116_IGG8-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE209601_2_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HGC27	DepMap CRISPR Gene Dependency	1.0	2.27208
MAZ	ENCODE Transcription Factor Targets	1.0	null
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4629-01A-02R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.00298
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMIM10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04401
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146074_10_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285696
OV56	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37853
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.30535
GTEX-WRHU-0826-SM-3MJFN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941078
Bosentan (hydrate)_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0154874
layer 4 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48291
GTEX-PWCY-0426-SM-48TCW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919966
Perturb_5188_KO_Xpo5_SRP109172	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.80981
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.434142
GSE231799_3_v_5_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
periventricular stratum of r1Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05476
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02707
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NFYB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169205_0_v_2_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XOT4-1126-SM-4B66E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.297
SOX2_Deficiency_GDS4853_322_human_AZ-521 gastric cancer (GC) cell line - 24 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.36081
CEBPB_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE233183,GSE233187_3_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8XE-0426-SM-3DB91	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934654
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.27586
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.265
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.3831
H3K9ac_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE244072_10_v_3_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
KE-73-XV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.448056
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7646-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ouabain (Octahydrate)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0210513
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of r10BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06171
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.34294
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7227_KO_CDK8/CDK19_SRP271652	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZSCAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45405
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6790-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3458-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal compact bone morphology	MGI Mouse Phenotype Associations 2023	1.0	null
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308374
Lateral visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16517
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	1.0	1.03034
Perturb_3728_OE_Fut9_SRP242022	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.84988
WM1799	DepMap CRISPR Gene Dependency	1.0	2.33211
outer SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01322
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.942198
H3K27ac_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55158
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIX5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE182680,GSE182683_0_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15088_KO_Yap1/Wwtr1_SRP303521	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.06675
Niclosamide (olamine)_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0156242
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.23371
TAL1	ENCODE Transcription Factor Targets	1.0	null
AD-51-FB60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.419586
GSE119978,GSE180930_6_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMAD4-21741376-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4268
Bosentan (hydrate)_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0104961
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.316739
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.47028
U2OS	CCLE Cell Line Gene CNV Profiles	1.0	2.0245
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
midbrain raphe nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08401
Lung adenocarcinoma_LUAD_TCGA-86-8358-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXP1-21924763-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206270_2_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ED-71-GA72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.494557
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04369
SIN3A_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
APTO-253_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.017528
RAD21_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06433
ATF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-0526-SM-4BOQA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01922
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Heel bone mineral density	GWAS Catalog SNP-Phenotype Associations 2025	1.0	2.3699
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02441
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.567493
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.901199
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66291
HDAC2_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199606_5_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-216a	TargetScan Predicted Conserved microRNA Targets	1.0	0.085563
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JIMT-1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.94201
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELK1	ENCODE Transcription Factor Targets	1.0	null
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09835
GTEX-QEG4-0426-SM-33HC3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71443
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00927
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
S0-EE-Y737_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272339
wt1_17420277_e11dot5_urogenital_ridge_lof_mouse_gpl1524_gds2747	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.002102
FA-92-JL46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256382
Loperamide (hydrochloride)_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0175181
TAF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29678
GSE143830_0_v_1_trex1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PLEKHA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19494
abducens nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.997166
layer II of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.867226
Acute Myeloid Leukemia_LAML_TCGA-AB-2853-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
orbital frontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03015
PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
EEF1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16597
(S)-Crizotinib_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.038412
Abducens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23526
Primary somatosensory area, mouth, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16161
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.66353
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69549
GSE171292_6_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13636
GTEX-XPVG-0326-SM-4B653	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12328
Perturb_12791_KO_Trem2_SRP124787	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.39838
5-Azacytidine_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0493448
BE-79-QU25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20822
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.628309
Perturb_3360_KO_Bach2_SRP267100	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.30345
BE-38-UW72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.350978
CAL54	CCLE Cell Line Gene CNV Profiles	-1.0	-3.20863
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.86777
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7155-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.018
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10803041-elife-86204-supp2.xlsx-Bulk_-_Snc-KD_in_NM-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.95663
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.35048
GTEX-X62O-0826-SM-46MW8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859434
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WQ-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
t69-brown-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.84748
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5982-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteromedial visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49426
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.85371
hsa-miR-2053	TargetScan Predicted Conserved microRNA Targets	1.0	0.075559
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24567
GSE126463_4_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLF4	ChEA Transcription Factor Targets	1.0	null
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24235
H3K4me1_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Regorafenib_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0531086
ML264_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0408182
MKN28	DepMap CRISPR Gene Dependency	1.0	2.43208
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE225218_9_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
heart	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.72534
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRCC3	Pathway Commons Protein-Protein Interactions	1.0	null
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R3RS-0526-SM-3GADG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17492
hsa-miR-4795-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
VCAP_PROSTATE	CCLE Cell Line Proteomics	1.0	14.2262
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.980006
Perturb_5207_KO_Ddx6_SRP137732	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.72152
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3ZE-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.4943
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BHLHE40_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.47708
CREB1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TET1-21490601-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 5 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09258
Lateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.8823
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.435
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG8-0326-SM-4LVN4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980503
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.90618
Almonertinib (hydrochloride)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0272638
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
H3K27ac_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.82414
Perturb_10932_KO_Lkb1_SRP351964	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.74399
hsa-miR-3671	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
ATF2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paclitaxel_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0237524
PBDC1	Pathway Commons Protein-Protein Interactions	1.0	null
Malotilate_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0226344
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Darinaparsin_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0263255
AZD2858_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0303564
Perturb_6849_KO_PRE2_SRP273076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.8673
periventricular stratum of r6Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12964
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.92222
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	1.0	2.92892
AB-83-EW00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263082
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24777
Perturb_14939_OE_hPRDM15_SRP182668	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.87253
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.619068
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Futibatinib_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00949729
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.786783
Perturb_5867_KD_Cpsf6_SRP336206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.71037
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-628-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Gli1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.8476
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303818
CAL120	CCLE Cell Line Gene CNV Profiles	1.0	1.77956
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A1HS-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE189859,GSE189861_0_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42041
embryonic lethality prior to tooth bud stage	MGI Mouse Phenotype Associations 2023	1.0	null
ATAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39729
EZH2	ENCODE Transcription Factor Targets	1.0	null
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.933852
STAT5A	ENCODE Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10R-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Darolutamide_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0173338
CREB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6312
Dbf4-dependent protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.784
Organellar small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.97
GSE222758_0_v_2_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SNOS-0926-SM-4DM7A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09763
GTEX-S32W-0626-SM-2XCBG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32188
496100472_PCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.93963
Hyperplasia	CTD Gene-Disease Associations	1.0	1.47915
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_18Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.06587
Ectorhinal area/Layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.115
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.56911
Regorafenib_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0295385
JUN_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-let-7a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
mantle zone of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14226
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.91738
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RO-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5332-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158815_5_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LK2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60398
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5979-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MEL270	DepMap CRISPR Gene Dependency	1.0	2.14731
MYCN-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12192
ESRRA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD-20-MH57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262212
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.843215
Lung squamous cell carcinoma_LUSC_TCGA-66-2800-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11556
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SREBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
MITF	ChEA Transcription Factor Targets	1.0	null
GSE100316_3_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18432
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE223908,GSE223909_4_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZIC5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.1948
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14481
GSE77108_0_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.92188
Perturb_17444_KO_Trp53_DRP003641	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE221539_1_v_3_lrrc10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gemcitabine_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0223927
muscle	GTEx Tissue Gene Expression Profiles	1.0	1.10109
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.4982
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38985
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0526-SM-3LK7W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911405
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.898267
Brain Lower Grade Glioma_LGG_TCGA-VV-A86M-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIRT6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54526
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE206516,GSE206518_5_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-13-CX28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.403261
Tetracycline (hydrochloride)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0233325
LK2	DepMap CRISPR Gene Dependency	1.0	2.30861
SK-MEL-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01555
SNU761	DepMap CRISPR Gene Dependency	1.0	2.40499
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.785391
GTEX-XYKS-0226-SM-4BRW3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0437
COLO679	CCLE Cell Line Gene Expression Profiles	1.0	1.59216
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.32741
Osimertinib (mesylate)_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0140962
hsa-miR-3607-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
AA-48-XT80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.554659
Daidzin_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0302632
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.91043
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.953573
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.865
hsa-miR-1294	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
H3K4me1_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
r3 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10708
TE4	CCLE Cell Line Gene CNV Profiles	1.0	1.57597
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.83447
GSE95685_4_v_5_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE156115_2_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_AG-14361_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153395
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26884
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1847
BAY1125976_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0288901
RH30	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61238
GSE163862_0_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-3688-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.003282
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.957632
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57673
GSE157592_1_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H4K20me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Ralimetinib dimesylate_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0184635
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.856512
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13574
Lung adenocarcinoma_LUAD_TCGA-97-8175-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XB-01A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TE1	CCLE Cell Line Gene CNV Profiles	1.0	1.44046
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
S0-EE-Y4UM_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235048
Selinexor _H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0216116
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.30465
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NFK9-1326-SM-3LK5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838717
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304231
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE129389_0_v_3_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
superficial stratum of r9BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11896
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
skeletalmuscle	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.57137
Lung squamous cell carcinoma_LUSC_TCGA-21-1079-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TSE9-0011-R7A-SM-3DB7P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83569
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5263-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC827	DepMap CRISPR Gene Dependency	1.0	2.04841
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A857-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_THAP11_20581084	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-M7-A724-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE149075_3_v_11_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.908925
IRF4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112763,GSE112767_0_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Allopurinol_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0333578
TTYH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08435
ZBTB33_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.301301
r6 part of nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00768
MYC_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
heart_6b	HPA Tissue Sample Gene Expression Profiles	1.0	3.39854
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NC-27-AD53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242889
hsa-miR-20a	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967242
SLC25A13	Pathway Commons Protein-Protein Interactions	1.0	null
GSE225647_1_v_3_srsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
19489030-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31334
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11627
A549_Enzastaurin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161791
GTEX-POMQ-0326-SM-2I5FO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23058
Perturb_17281_KO_Gja1_SRP247546	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.32576
4024_IDH2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.80214
C32	CCLE Cell Line Gene Expression Profiles	1.0	1.84937
ATR_KD_GSE54268_664_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RXRA	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2696-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cepharanthine_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0276959
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.840437
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.37509
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
polymorphic layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.129
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66327
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.549351
Necrosis	CTD Gene-Disease Associations	1.0	1.31297
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152287
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00541
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TR-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
PMC3878729-1471-2148-13-273-S1.xls-Gene_List-Zfp9_ZNF25	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFJO-1126-SM-4LVLZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877134
Perturb_12785_KO_C5ar1_SRP097094	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.82301
GTEX-RU1J-0008-SM-46MV9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827329
Nevirapine_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0307598
GTEX-OXRK-0826-SM-2HMK7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33057
JUND_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner SZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4712
Lung adenocarcinoma_LUAD_TCGA-05-5428-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A72Z-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.79867
ZNF292	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45398
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21033
GTEX-X4EP-0326-SM-3P5Z6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981514
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2913
hsa-miR-3689a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22022
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.991401
GSE137177_2_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CHP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44987
r7 part of nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1866
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.05858
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248327
Pimitespib_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0222853
Perturb_17244_KO_Klf3_SRP029447	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.53084
Perturb_16924_OE_Prdm16_SRP189927	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.5878
PMC9170756-mmc6.xlsx-all_differential_proteins-Table_S3_The_JUN-targeted_responders_to_FFA_treatments_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ED-81-ZH14_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264202
BE-27-RQ61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26941
HCC4006	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.995802
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.2734
PEX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24069
Glasdegib_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0511091
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.681344
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957506
hsa-miR-4797-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GSE135030_11_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_9280_KD_DDX24_SRP153815	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.87332
Primary somatosensory area, unassigned, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14112
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-2682	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
PMC6977700-aging-12-102667-s004..xlsx-Stage4-The_identified_749_dysregulated_LmiRM-CTs_in_stage_4_of_MI_6_months_after_MI_using_our_method_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEC-1226-SM-4AT65	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38119
r7 part of rostral ventromedial reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00419
TGBC18TKB	DepMap CRISPR Gene Dependency	1.0	2.1653
Jackson-Weiss syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A766-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4427	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE114992,GSE114993_0_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CHD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTBP2	ENCODE Transcription Factor Targets	1.0	null
Perturb_11070_KO_Tdg_SRP251657	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.98013
Perturb_4741_KD_Mettl3_SRP354177	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.297
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH69	CCLE Cell Line Gene CNV Profiles	1.0	1.59391
heart	GTEx Tissue Gene Expression Profiles	1.0	2.18987
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.585443
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0923
GSE215351,GSE215794_1_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MORCPR	CCLE Cell Line Gene CNV Profiles	-1.0	-1.85241
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45127
MEWO	CCLE Cell Line Gene Expression Profiles	1.0	1.38901
RAD21_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.92493
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.39819
Acamprosate	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
CXCR7_Deficiency_GDS3183_604_mouse_Neonatal semilunar valves	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5096-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81599
Bendamustine_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0220755
K562_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161843
Skeletal muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.301
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12494973-41467_2025_63880_MOESM1_ESM.pdf-438-ESR1_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-2113	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Ouabain (Octahydrate)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0231838
Perturb_1757_KO_p300_SRP250516	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.35163
r5 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.77474
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.391923
Bosentan (hydrate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0246412
Perturb_6530_KD_Shroom3_SRP132086	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.71606
Pimozide_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0300387
Berberine (chloride hydrate)_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0269251
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.10639
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.7194
THAP11	ChEA Transcription Factor Targets	1.0	null
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83253
GTEX-XGQ4-0526-SM-4AT6C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09351
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
precuneus, right, superior lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.878619
posteroventral (inferior) parietal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.867471
HOXB4	ChEA Transcription Factor Targets	1.0	null
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21175
zfpm2_19411579_heart_lof_mouse_gpl1261_gds3659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.455439
NC-35-BF58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.421497
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.22156
GTEX-XMK1-0326-SM-4B652	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19904
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D4REFED48h_750_AR--Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.981063
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
Psoas_Muscle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.01586
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
C170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45576
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13628_OE_Fosl2_SRP200662	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.76719
CC-03-PW00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278438
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
subthalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.928315
NCIH747	CCLE Cell Line Gene CNV Profiles	-1.0	-2.45792
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02442
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.237
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU869	CCLE Cell Line Gene Expression Profiles	-1.0	-2.13058
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-4J-AA1J-01A-21R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.94125
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20164
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.38868
H3K4me1_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SLITRK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0061
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Loperamide (hydrochloride)_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0116163
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FA-63-WI26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.31726
Perturb_13799_OE|KO|KD_H33a_SRP100500	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.4539
superficial stratum of r3BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10765
esophagus	HPA Tissue Gene Expression Profiles	1.0	0.844698
amygdalohippocampal transition zone, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0446
GTEX-XV7Q-0726-SM-4BRV6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855916
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3M_Peaks_YAP1MAMLD1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
ChIP_TCF3_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PSMA4	Pathway Commons Protein-Protein Interactions	1.0	null
ED-91-LY45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.662248
VB-92-JQ72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214867
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10695
r10 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.09878
GSE118794_0_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Isocorydine_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0235861
GSE224004,GSE224005_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A97G-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-60-DR81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.409297
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51643
MCAS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.953682
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Medullary reticular nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40439
hippocampus (hippocampal formation)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.913408
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4182_KO_Foxp1_SRP102696	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.16652
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.608621
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POYW-0526-SM-2XCEY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54731
Retrosplenial area, lateral agranular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14811
CEBPD	ENCODE Transcription Factor Targets	1.0	null
GSE217115_2_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.853561
Posterolateral visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.77865
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.401007
YE-55-YX75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201921
CEBPB_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-F2-A44G-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.55467
TAK-901_NCI-H2347	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00449398
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATF3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Tetracycline (hydrochloride)_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0161354
layer IIIb of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.996064
GSE200839,GSE233826_3_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
orbital frontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05743
hsa-miR-548ak	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
Ribociclib_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0309453
PPARG	ChEA Transcription Factor Targets	1.0	null
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09404
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4703-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
Acute Myeloid Leukemia_LAML_TCGA-AB-2812-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stomach	GTEx Tissue Gene Expression Profiles	-1.0	-0.880386
FD-15-HD09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.605798
Prostate adenocarcinoma_PRAD_TCGA-KC-A7FA-01A-21R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
sclc21h	HPA Cell Line Gene Expression Profiles	-1.0	-1.57405
skin_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.51374
Perturb_4163_KO_Aki2_SRP325507	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.99818
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.5604
SK-MEL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.48335
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.43874
estradiol_homo sapiens_gpl570_gse23610	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Niclosamide (olamine)_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0115092
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.75751
locus ceruleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.31519
Bexarotene_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0127316
ESRRB-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-1677-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rimonabant (Hydrochloride)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0273568
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE190322,GSE190324_3_v_4_rbm4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bone mineral density	GWAS Catalog SNP-Phenotype Associations	1.0	0.369252
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FGFR1_mutant_25_GDS4046	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.51074
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62602
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YD15	CCLE Cell Line Gene Expression Profiles	1.0	1.61899
SRF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IE-44-GZ79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292065
MYC_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TIMM23	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25064
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.66405
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE248883_0_v_1_shmt2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JF-84-QZ64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.481052
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10U-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923515
Adrenocortical carcinoma_ACC_TCGA-OR-A5K9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_16939_OE_Prkag1_SRP162537	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.61217
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50498
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.872284
SAP30	ENCODE Transcription Factor Targets	1.0	null