association	dataset	threshold value	standardized value
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6384
BRD-K17245631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83363
PMC10169359-13058_2023_1653_MOESM1_ESM.xlsx-Table_S9-Table_S9_Genes_differentially_expressed_between_TP53_mutant_and_wild-type_pBCs_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
AIM2 inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.627
BRD-K01762107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06092
GSE176093_2_v_3_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K08940439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81083
GSE145476_2_v_0_hopx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K48-linked deubiquitinase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K88099511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73926
GSE133087_5_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SPAST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70534
NELFB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0058649
cyclothiazide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22184
BRD-K02240568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04027
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE128634,GSE128636_4_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Intermittent asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
A549_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145205
PMC8526018-KAUP_A_1856493_SM1378.xlsx-Table_S5-_DUB_genes-Table_S5_Compared_deubiquitinating_enzyme_genes_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
GSE199606_5_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45565
LPIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47728
BRD-K30105551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35671
GSE223008_7_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162469
PMC5444746-oncotarget-08-30328-s002.xlsx-SI01_ChIPSeq_H3K9me_AR-Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF837	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08368
GSE221327_4_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K67813189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87757
ZNF579	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4726
MCF7_Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132707
BRD-K88739137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30997
Artery	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A05422420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38438
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9747
4371_KIAA1958_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.58057
BRD-K77903467	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13422
K562_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213935
Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
BRD-K83010768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26106
GSE167886_3_v_1_chd7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137006
PLPP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00666572
GSE185635_0_v_1_ncor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7607_RUVBL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.508583
K562_Pirarubicin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0117314
GSE202284,GSE202289_1_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K96218803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65081
GSE217405_0_v_1_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE124410_2_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ADAD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61457
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193177_1_v_2_st266_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K63921431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10364
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6634
BRD-K59064238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74241
K562_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188082
Bosentan (hydrate)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00489138
K562_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153288
GSE136894_1_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTV1DM	DepMap CRISPR Gene Dependency	1.0	2.31307
Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.509691
GSE205163,GSE205164_3_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K39546571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62406
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1456
FADS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19465
GSE228727_2_v_0_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Plagl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.989
GSE199606_5_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21815
METTL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01772
PSMD13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93941
K562_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156951
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K57821544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34239
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65458
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47832
BRD-K46639367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41231
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.592
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149264,GSE149267_4_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K53936012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78855
SLC22A5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82437
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
MTA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00550613
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:I08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11244
BRD-K41690760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24095
BRD-K45952474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18839
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.1523
IC-05-AW29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286105
ETV3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4187
BRD-K11581306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52211
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
K562_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183452
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K92570288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38218
GSE228261_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE209680,GSE209683_0_v_1_nfat5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ERRFI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13354
Bronchial epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.271
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5453
BRD-K03901181	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61805
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.49335
NDUFB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42398
BRD-K73581966	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21548
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8852
BRD-K78252315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60345
PMC9745835-supp_079195.122_Supplemental_Table_1.xlsx-ADAR-KD-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
6548_POLR2G_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.512651
GSE113106_2_v_1_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K85722065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56366
BRD-K36644177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63299
GSE87862_0_v_1_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K86467057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00192
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0107179
BRD-K34519525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0798
CRCGN014_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9043
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8822
GSE152055_0_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K41310594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00867
GSE148066,GSE157787_11_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_10_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.884
GSE229468,GSE229471_0_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.1268
cysteine-type deubiquitinase activity	GO Molecular Function Annotations 2023	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K39328339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98654
IL17A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00653625
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1915
Pollen allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.26
K562_Costunolide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164622
BRD-K42091424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43748
496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.30577
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4657_CARMIL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.591903
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131364
GSE229973_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22533
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.9604
BRD-K81804676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36817
BRD-K02530287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01703
PMC8528285-pbio.3001085.s010.xlsx-Fig_7G-MAX_KO_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K88070218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12289
K562_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138746
ANKRD30A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00232
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K20586104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95516
BRD-K79376287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64131
GSE210383_0_v_1_trim71_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE218500_0_v_3_ruxolitinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K25097691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0677
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_9_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
1535_CFH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.709573
COPS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1108
BRD-K49211735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07013
GSE93674_2_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9782
GSE236437_2_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121949
Conjunctivitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.469
BRD-K46376359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2497
MKN28	DepMap CRISPR Gene Dependency	1.0	4.05098
SMAD5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8083
Helab	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.648
GSE219195_0_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:M12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15314
ALDH18A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09027
K562_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209036
BRD-K31908823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05494
K562_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144425
GSE229973_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE205163,GSE205164_9_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
CAMK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81616
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
GSE101112_6_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_AMG-900_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164457
GSE158320,GSE183351_2_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K64591035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17519
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.094
A549_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189334
GSE120612_6_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
PSMA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1513
MCF7_Panobinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00559507
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K43387144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31933
PTPN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51355
GSE157296,GSE157298_4_v_2_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190235_3_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K64692525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13151
CRCGN015_MCF10A.WT.HP_24H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16468
VPS45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33351
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K83341545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09199
MICA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15427
Gastrointestinal allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.798
GSE189653,GSE203344_2_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7338542-41389_2020_247_MOESM5_ESM.xlsx-BRN2_2_of_3_UP_48_h-Symbol_POU3F2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MEWO_SKIN	CCLE Cell Line Proteomics	1.0	3.69668
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_4_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CCDC50	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00599636
BRD-K74173779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62369
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12439337-thnov15p9091s1.pdf-75-ENSG00000124766_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239844_11_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K96431636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36838
Fruit allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.499
A549_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143858
BRD-K13110820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56022
PPM1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50721
TAF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22914
GSE114690_2_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN013_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0273
Posterior midgut	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.599
FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1745
BRD-K83109105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89728
Basophil	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.544
MCF7_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019118
BRD-K17574409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27024
BRD-K91726436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06603
K562_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0259499
BRD-K89336453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34532
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137456
BRD-K83892314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61577
GSE215351,GSE215794_2_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COPI vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.803
GSE225083_0_v_1_kras_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEx Muscle 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-5.94821
NIHOVCAR3	DepMap CRISPR Gene Dependency	1.0	9.69616
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K70721203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09089
S1PR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15993
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.27265
K562_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141281
KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	4.17046
BRD-K06146578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24189
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166577
GSE158834_11_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE196962_2_v_3_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nuclear membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
K562_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183368
CRCGN011_HEPG2_24H:P07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13085
K562_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167404
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZSCAN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25525
BRD-K72125659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65663
CRCGN015_MCF10A.WT.HP_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38724
GSE151829,GSE151831_7_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
CRCGN015_HEPG2_48H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37712
BRD-K83297764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08069
HOXB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06967
BRD-K53717076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4692
deubiquitinase activity	GO Molecular Function Annotations 2025	1.0	null
Synaptic vesicle protein transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.56
BRD-K62182950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05162
GSE229671,GSE229673_2_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	1.0	null
RPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26736
GSE221327_5_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229580_2_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123737
GSE184892_0_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135352_0_v_1_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216538_0_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE87144_3_v_1_rorc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE200320_3_v_2_mfge8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K12531686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14392
MCF7_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128006
Alveolar epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.893
K562_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019802
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_1_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Waist circumference	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.530103
NDUFA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03598
NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	8.99683
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POMC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20808
interleukin-1 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.173
GSE89018_6_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140607_5_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18085
BRD-K97934318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08164
BRD-K60454544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46909
GSE180185_4_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_11_v_5_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K89364982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25049
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_spleen-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4403
BRD-K04269696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49677
BRD-K95852319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86841
GSE134191_3_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Hesperadin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015955
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111138,GSE111149_1_v_3_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE80383,GSE126406_1_v_0_isl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.867
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.9465
MAFF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39763
BRD-K98757606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2151
dihydroergotamine-mesylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59286
Glycated hemoglobin levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.652288
K562_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168437
Organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K92239253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01043
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_5_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0233873
CRCGN012_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4459
ERF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7737
GSE249544,GSE249637_6_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223893_2_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GALNT10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00660982
GSE180200,GSE180201_12_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.891
BRD-K06997715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22551
Cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228141
K562_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181501
GSE196117_6_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114690_2_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE221327_4_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
10917_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.62901
GSE48812_9_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K99833695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50151
BRD-K62372121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35443
GSE229973_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K54742099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14494
BRD-K08799663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00029
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K79322550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85653
K562_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157031
bf2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
BRD-K42361742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41994
BRD-K86102179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62322
K562_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196503
GSE180200,GSE180201_15_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81835
GSE169263_1_v_0_armc5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K01166365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98193
GSE185944_5_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200538
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K82314391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02007
PFKFB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00639397
GSE221742,GSE221743_1_v_2_sipa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Marginal zone lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
K562_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0229231
K562_Curcumin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.031535
GSE212486,GSE212488_2_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:H16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08984
MARCHF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01654
GSE125014_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K67533212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36647
BRD-K19702946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09708
GSE174383_1_v_5_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K95338817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.389
CRCGN016_MCF10A.TP53.M_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6183
ZNF596	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30699
K562_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187363
Rhabdomyosarcoma	DisGeNET Gene-Disease Associations	1.0	null
Cells - EBV-transformed lymphocytes	GTEx Tissue Gene Expression Profiles 2023	1.0	1.62175
BRD-K06863452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66124
GSE160083,GSE160084_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Sunitinib_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00555337
GSE210476_2_v_1_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Occupational asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
GSE205163,GSE205164_5_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00970605
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12642662-media-1.xlsx-S9-Table_S8_TEAD1_ChIP_v_MDS_score_overlap_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K87878159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47806
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109182
BRD-K52859120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29171
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7337
GSE89767_2_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154767_2_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240030,GSE252532_0_v_2_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216238,GSE216241_0_v_1_tonsl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07944
RPRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58703
EIF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24794
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
death-inducing signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.737
BRD-K23620459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36256
Muckle-Wells syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
GSE48812_0_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1	Rummagene Transcription Factor Associations 2026	1.0	null
MAML3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36835
GSE122711_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MFE280	DepMap CRISPR Gene Dependency	1.0	4.5264
Conjunctival disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.439
BRD-K32916996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65099
BUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95555
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE175787_13_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184045
BRD-K76588894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08916
K562_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157625
BRD-K18562847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80043
BRD-K48407262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65571
GSE168596_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_PHA-680632_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141169
Pyroptosome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.531
Myometrial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.544
GSE167224,GSE168147_3_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ECC4	DepMap CRISPR Gene Dependency	1.0	2.84387
BRD-K20846358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97084
MXRA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00055
BRD-K23280067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69317
PMC11242342-jcav15p4513s1.pdf-25-JRKL_JRKL	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213650_3_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5527282-ncomms16041-s3.xlsx-M_LPS_-_gene_signature-Supplementary_Data_2_Full_gene_list_of_M_LPS_-_signatures_as_defined_in_figure_3_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04005364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.97266
Urate levels (BMI interaction)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
K562_AG-490_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0239532
GSE141453,GSE141454_0_v_4_card11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Vascular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147333
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Panobinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00669696
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143512,GSE143513_0_v_1_nr4a3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196117_1_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MANSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21238
NSC43673	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
K562_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173839
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9509360-41419_2022_5262_MOESM6_ESM.xlsx-Fig_2D_MSC_targeted_RNF4-Down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K65432867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39523
GSE213588_9_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K66762690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01023
BRD-K42457027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55929
GSE89018_1_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K94273044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05848
Lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.161
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05264
Allergic asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.992
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_1_TRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K84048601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3227
FAM20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55085
Endometrial luminal epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.613
GSE166536_1_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200311
BRD-K62624148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25688
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131006
BRD-K70468140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37092
CRCGN015_MCF10A.TP53.M_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0365
GSE154767_2_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.81954
CCDC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61075
Type III protein secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.568
BRD-K91271834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.121
GSE244940_0_v_1_edf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Allergic rhinitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.189
BRD-K21955645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06781
K562_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136381
CRCGN014_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1695
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K62621376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12689
BRD-K72359187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10742
GSE100102_0_v_3_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Respiratory epithelium cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.353
PSMB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19405
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.077
GSE216273,GSE216292_14_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180200,GSE180201_3_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.917
GSE215849_2_v_1_muc1_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131021
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221356_1_v_0_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8	Rummagene Transcription Factor Associations 2026	1.0	null
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_WHI-P154_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140797
BRD-K08154407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94548
RPS3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46345
GSE198165,GSE198166_9_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K42814713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00615
BRD-K91419355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0246
Mastigoneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.746
GSE148193_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216538_5_v_6_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K95350313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04192
K562_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243713
GSE135030_8_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CYTIP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00746175
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5891
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4559
MCF7_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00906881
BRD-K66690073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17844
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132927
COX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65143
BRD-K28619632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2287
GSE196962_4_v_1_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.52828
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6938365-pone.0226733.s019.txt--GATA2_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.34714
K562_TMP195_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175519
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Uterus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
WDR5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75753
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Respiratory allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.336
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7462
GSE189653,GSE203344_5_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K06678077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42513
Mitotic arrest phase fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
BRD-K64704925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92417
GSE191015_0_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-GATA3_only-Gene_Name_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02367
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252924
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.659379
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.507
Apoptosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.229
GSE139239_3_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100626_FWM_no dementia_TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.19429
KB-72-ID36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264705
Bronchial mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.517
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270632
PPIE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21848
CDC23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33626
K562_Fulvestrant_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0247829
GSE89018_1_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K89724519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07536
GSE132386_2_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Peritrophic membrane	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.492
BRD-K64173373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64153
Extrinsic asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.998
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.22238
BRD-K98140933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93091
Pollen coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.909
CA-42-YI34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219627
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
PMC6938365-pone.0226733.s019.txt--ESR1_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145215_2_v_1_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nose disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.245
GSE154767_4_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MARK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27205
BRD-K45428339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50519
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SKIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05268
BRD-K71842353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4599
CRCGN016_MCF10A.WT.HP_24H:A21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.417
LRCH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13147
GSE135705_5_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K76114616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05206
GSE248045,GSE248046_6_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_12_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
5762_NPAT_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.597354
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K07013504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32127
BRD-K71554049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18345
GSE196962_2_v_1_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141763
BRD-K22957824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34247
THOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49087
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48514
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.3289
MCF7_Dacinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.005706
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5561
MCF7_Clevudine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194772
GSE158502,GSE158506_3_v_0_fat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K19830171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02622
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4408
CRCGN017_MCF10A.TP53.M_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34601
BRD-K29144638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62654
AC-97-KP88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238277
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.164
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.78686
GSE196699_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1194
GSE77108_5_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K37989903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46507
ELMOD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15937
BRD-K89376872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36783
RRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85848
CRCGN015_MCF10A.TP53.M_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.335
BRD-A68865339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2551
K562_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190846
GSE153354_0_v_1_tcf19_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9496
BRD-K83815133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79559
IgE immunoglobulin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.537
K562_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017424
GSE160373_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Knrk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.672
TF1	DepMap CRISPR Gene Dependency	1.0	2.71164
BRD-K61451401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88103
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7802
496100432_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04886
GSE179974_3_v_0_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE203308_9_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_S7C-GENE_LIST_UPLOADED_TO_ENRICHR_MAX_KO_TESTES_627_GENES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
Bronchial epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.324
BRD-K83475223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35419
GSE221327_5_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149264,GSE149267_2_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPP1R12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.36056
GSE44157,GSE44163_1_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TFAP4::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6279
Microphthalmia with limb anomalies	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
Aorta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K69840402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91763
GSE205163,GSE205164_3_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE42805,GSE42811_1_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K82324807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80578
BRD-K48235533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54357
BRD-K47492310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03052
GSE244199,GSE244200_0_v_1_chmp5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202284,GSE202289_5_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K32983008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07167
GSE198165,GSE198166_7_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_SIX5-gene_SIX5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164483_2_v_0_venetoclax_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CBM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.045
GSE145323,GSE145324_3_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE110178_5_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5287
GSE214823,GSE214824_6_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
MCF7_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144044
ZNF417	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6436
GSE179002_2_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lower respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.161
Environmental induced asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.178
BRD-K40558736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34044
CDCP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00703404
BRD-K96898856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27862
GSE207914_1_v_7_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A03898562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41299
BRD-K78965436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18471
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281471
Milk allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
GSE160373_1_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Panobinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00921653
GSE151829,GSE151831_1_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_4_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K90852412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19056
BRD-K92884779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14369
BRD-K59434830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30647
Infigratinib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00615601
GSE133087_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K54686062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05924
GSE216352,GSE216354_1_v_0_keap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K82105033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38254
K562_Entacapone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017219
GSE227634,GSE228381_0_v_7_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE100316_7_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lucanthone_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0111628
BRD-K88988134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46283
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE136894_2_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.3414
BRD-K91235484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1764
GSE217405_0_v_1_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K68667113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13596
Legume allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.512
ASPC1	DepMap CRISPR Gene Dependency	1.0	2.94584
GSE123825_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Atopic dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.854
2988_FBL_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.25778
GSE183251_1_v_3_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE187006_3_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE192689_0_v_3_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K68087668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27673
Laticifer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.131
BRD-K63787803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03372
K562_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166659
ANAPC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03739
BRD-K47087435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36732
GSE221020,GSE221023_2_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211177,GSE211178_9_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K59182232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6543
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92513859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74945
EDARADD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20299
CRCGN016_MCF10A.TP53.M_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.90443
OV7	DepMap CRISPR Gene Dependency	1.0	3.93152
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.579657
BRD-K88707941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16172
K562_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178797
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111138,GSE111149_1_v_0_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K75192396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93401
GSE255680_1_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K95455263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34628
K562_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192325
CENPM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00542
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154961
GSE176008_8_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K40490682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14829
MCF7_Temsirolimus_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128609
GSE236502_2_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140445,GSE140448_1_v_0_trim28_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254788
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K98061543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98292
GSE223893_1_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0245359
GSE221742,GSE221743_1_v_0_sipa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Urticaria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.334
Tadalafil_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0226339
GSE174383_1_v_7_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KINGS1	DepMap CRISPR Gene Dependency	1.0	5.88263
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pharyngeal cavity	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.504
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.902
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE233679_12_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3118	DepMap CRISPR Gene Dependency	1.0	10.6839
GSE128634,GSE128636_2_v_0_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SGSM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.354
Contact dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.826
GSE113952,GSE113953_1_v_0_chtop_human	RummaGEO Gene Perturbation Signatures	-1.0	null
1578_CHML_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.641585
K562_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0202716
BRD-K18462967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21709
BRD-K05261060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18656
A549_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142984
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5F-Up_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K54141134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5105
GSE196962_4_v_6_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219398
8598_SUPT5H_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.57295
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
20_ABCB10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.54822
A549_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146129
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K37269981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05236
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.395456
Mental Retardation	DisGeNET Gene-Disease Associations	1.0	null
GSE178255_5_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217452_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12619835-41467_2025_66007_MOESM13_ESM.xlsx-Sheet1-Basal_like_KLF5_peaks_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
monolayer-surrounded lipid storage body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.042
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.208
BRD-K95575699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3276
BRD-K92904754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59139
BRD-K79020643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52687
PMC9314667-Table_1.xlsx-Regulons-MITF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.5943
BRD-K53720386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36799
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5199
BRD-K07350528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10058
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263933
PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MAX_KO_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE48812_2_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K68118416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77587
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K97359891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88696
BRD-K79159743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25846
GSE145215_0_v_3_krt13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.585
BRD-K31407552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17034
K562_Temsirolimus_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013886
GSE101546_2_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HBE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.547
Blau syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
LB771HNC	DepMap CRISPR Gene Dependency	1.0	9.63041
GSE148200_0_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K45472595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00511
BRD-A23434937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03787
BRD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37994
K562_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0217951
CGA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604382
A549_Toremifene Citrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148
RASGRP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00505886
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10823279-CAS-115-283-s001.xlsx-Table_S6-Table_S6_List_of_182_genes_particularly_down-regulated_by_AR_in_AILNCaP14_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0242116
K562_Fasudil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174128
BRD-K98876398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.63706
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Oogenesis phase fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
BRD-K28720546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0688
BRD-K20157822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63554
GSE174701_4_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.2158
Amoeba	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.3926
GSE157894_2_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1857
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27265
GSE130383_1_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ataxia	DisGeNET Gene-Phenotype Associations	1.0	null
Bcl3/NF-kappaB2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.881
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224471
nuclear membrane	GO Cellular Component Annotations 2025	1.0	null
BRD-A34492468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48272
K562_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194059
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.939
GSE174498,GSE174500_5_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE173232_1_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K18629365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67503
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.10199
GSE190322,GSE190324_3_v_4_rbm4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152937_6_v_5_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02191
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE157777_1_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K29969800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30709
CIITA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.324
PMC12337709-mmc3.xlsx-Wild-type_vs_RAG1_KO_Myeloid-Unnamed_1_RAG1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K63410075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73065
496100574_HIP_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.48723
K562_Barasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191894
K562_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0268578
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE200352_10_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
BRD-K05786443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05486
NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.3936
Chronic rhinitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
ZNF184	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.0346
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K16717067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23317
GSE120612_7_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K48-linked deubiquitinase activity	GO Molecular Function Annotations 2025	1.0	null
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0493
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9085
GSE203308_14_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN1_n_EN1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE136894_1_v_0_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160373_5_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K71460915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03567
GSE96649_1_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ECSCR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00543171
K562_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140363
BRD-K00411149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0578
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.5376
BRD-K15694916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70974
GSE178255_3_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157777_1_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HEY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2707
K562_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141416
BRD-K80495774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14188
BRD-K04786080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15928
BRD-K37271110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00225
GSE98964_0_v_2_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4497
BRD-K72647169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35946
GSE253041_1_v_0_ramp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K34209560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34453
ZNF416	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70447
PMC9225015-elife-72879-supp6.tsv--DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221327_10_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.161
BRD-K87930002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23041
CRCGN010_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88659
A549_CYC116_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012401
BRD-K37931645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13666
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8423434-mmc7.xlsx-SOX2_HENSM-Genes_n_2733_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K20542687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72493
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Alendronate sodium trihydrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212898
BPNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05301
chr10_15860304_A_G_b38	GTEx eQTL 2025	1.0	1.29946
BRD-K72549552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03897
GSE93674_2_v_3_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Latex allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.416
GSE175787_13_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
UACC-62 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.843
GSE223908,GSE223909_1_v_6_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5299
LUBAC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.005
GSE129244_3_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Oligodendroglioma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K89366259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19728
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K95788660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02042
HCE4	DepMap CRISPR Gene Dependency	1.0	2.25869
cysteine-type peptidase activity	GO Molecular Function Annotations 2023	1.0	null
Cerebellar Ataxia	DisGeNET Gene-Phenotype Associations	1.0	null
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.540088
MCF7_CUDC-907_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00618766
1652_CLHC1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.611105
BRD-K97256018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39335
BRD-K80073743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59628
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_PF-573228_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0178927
GSE210476_2_v_7_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K33805386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0063
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Bronchial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.2
GSE234340_3_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.7027
BRD-K00797068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04425
GSE140607_1_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE189653,GSE203344_5_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FARSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17614
PAX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60474
GSE148200_3_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16475
GSE197117_0_v_1_kdm6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Wheat allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Non-Small Cell Lung Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.3893
Common cold	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
BRD-K05228434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53312
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
GSE190235_1_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DDRGK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00488555
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Microtubule bundle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.626
PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_10_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53772256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26755
BRD-K85200795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10071
ZSCAN29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08351
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203308_6_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LIVF001-023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03005
BRD-K41888813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08835
BRD-K37971917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44263
BRD-K10513366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18053
Cardiomyopathy	DisGeNET Gene-Disease Associations	1.0	null
BRD-K99827210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16563
BRD-K93519076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37155
GSE205163,GSE205164_2_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100519_HIP_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.36296
GSE242647_2_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K23817660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12289
ISTMEL1	DepMap CRISPR Gene Dependency	1.0	3.59894
BRD-K02078126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85388
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K93337444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04934
GSE198165,GSE198166_8_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193993_1_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3698
CRCGN014_HEPG2_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91816
BRD-A43135847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36859
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.02144
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
CRTC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1819
Shrimp allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.356
BRD-K19764912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69351
BRD-K73899643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.45957
BRD-K90349877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12936
GSE223008_9_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.23911
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0104412
Endomembrane system	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
MCF7_AICAR_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150719
BRD-K42679315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46181
CBARP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60873
GSE147662_3_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217441,GSE217443_1_v_0_ivosidenib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8423434-mmc7.xlsx-KLF4_HENSM-Genes_n_2172_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K15282657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90687
KCNA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93312
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
496100463_FWM_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.42384
PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
Familial Mediterranean fever	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
BRD-K87617154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0974
C21orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30445
GSE172020_0_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Organelle membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
L-Cysteine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
BRD-K63212062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22647
GSE98898_4_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199034_1_v_2_pirfenidone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE176555,GSE176556_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:J02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22055
GSE205550,GSE205552_2_v_3_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TADA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28019
GSE221020,GSE221023_2_v_1_pten_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K76202128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65334
GSE169713,GSE169715_1_v_2_tert_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11906621-41598_2025_93656_MOESM6_ESM.pdf-6-ZNF267_ZNF267	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K62418408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.43566
K562_Filgotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170019
BRD-K79887921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25113
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nuclear envelope	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
Upper respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.996
GSE174701_5_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_6_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199606_5_v_7_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MOCS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0113
GSE210662_3_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8782
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.01399
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5677
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.388
BRD-K94014790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39974
K562_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177347
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149264,GSE149267_9_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92011556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95303
Chronic asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.981
PMC8424594-main.nxml--DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-HIF1_HIF2_miRNA_targets_CoCl2-Unnamed_5_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE95826_4_v_1_tcra_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K65368100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44483
GSE145915_3_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216538_1_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169571_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160373_1_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118816_0_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K80996561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14975
BRD-K29685390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48482
CRCGN015_HEPG2_48H:B19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02032
PUS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40058
PEX16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01991
BRD-K95018971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.60469
EXOC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06469
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bronchial smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.505
TEX41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26989
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.161
BATF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00704
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.771
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202284,GSE202289_3_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Type IV secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.18
BRD-K10989739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37608
K562_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020545
RAPGEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52048
K562_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166068
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4538
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.4211
Peach allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.224
IL9R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00579259
GSE111247_11_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K76713927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26703
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239635
K562_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215209
BRD-K79781106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53683
PMC6298254__F3	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K82868643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32349
Well Differentiated Oligodendroglioma	DisGeNET Gene-Disease Associations	1.0	null
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K79202867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88462
GSE223008_5_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160373_6_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE139239_3_v_6_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
BRD-K26689527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87505
GSE159678_6_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K03304013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05012
496100486_PCx_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.26972
GSE143782_7_v_11_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6298254__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Liver Cirrhosis, Experimental	DisGeNET Gene-Disease Associations	1.0	null
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
TACR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0060458
K562_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177348
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_D1_vs_D10-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K96663576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81609
GSE93309_5_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K22974051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55242
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K85527716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05034
DBTRG05MG	DepMap CRISPR Gene Dependency	1.0	3.14614
GSE225900_1_v_0_hsdl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K71184289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24464
GSE79663_2_v_0_tcf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Allergic contact dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.84
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	1.0	2.09326
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.946558
6771_PRKRIP1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.610927
HCC38	DepMap CRISPR Gene Dependency	1.0	2.00608
BRD-K37634338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02213
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_10_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE172490_5_v_3_junb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Quisinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0067816
Yy1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.733
PMC8202205-NIHMS1706275-supplement-Table_S3.xlsx-Day_2_GATA6-dependent_genes-GATA6-dependent_mRNA_expression_Day_2_Mesendoderm_FDR_0_05_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228347
BRD-K98682310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28867
PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-GATA3_only-Nearest_Ensembl_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K11165361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61621
GSE221327_4_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K35376105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1083
MDAMB361	DepMap CRISPR Gene Dependency	1.0	6.52478
BRD-K47165178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50073
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K64137284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35713
BRD-K52154207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72273
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.21075
GSE208254_4_v_5_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189515
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2031
Midgut epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.192
BE-27-RQ61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.308205
BRD-K30964193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86431
GSE205976,GSE205978_1_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185519_4_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K61441533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19952
Egg white	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.844
MCF7_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127887
A549_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181554
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE174701_4_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S3.xlsx-Day_4_GATA6-dependent_genes-GATA6-dependent_mRNA_expression_Day_4_Definitive_Endoderm_FDR_0_05_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K59087082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19478
Egg allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.33
BRD-K85977749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15276
BRD-K97106314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1051
GSE153137,GSE153140_2_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE81803,GSE81912_4_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K82539366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5785
PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.716684
K562_S-Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182092
BRD-K78866450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02524
A549_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176415
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
TFAP4::ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.6834
Shellfish allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.386
BRD-K60635455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36137
Fhm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.101
BRD-K95147720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15603
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6713698-109_2019_1809_MOESM2_ESM.xlsx-AR-PCOS-Gene_List_AR	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0250617
BRD-K44537081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60934
K562_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156864
A549_PCI-34051_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132676
BRD-K80803211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07836
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.3719
PSS008	DepMap CRISPR Gene Dependency	1.0	2.18727
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
COPI-coated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.8
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K86600397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80201
Six3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.3304
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147286
PMC12542114-12964_2025_2459_MOESM4_ESM.xlsx-HIF1_HIF2_miRNA_targets_CoCl2-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
SNUC1	DepMap CRISPR Gene Dependency	1.0	5.23291
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K70087673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1234
GSE206784_3_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_BMS-265246_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130619
BRD-K94452277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04789
K562_Cediranib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171563
BRD-K11666748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57525
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.94757
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0554
ZNF540	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38229
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210770_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165122_0_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100396_HIP_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.55376
GSE197564,GSE198512_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KPNYS	DepMap CRISPR Gene Dependency	1.0	3.79978
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.34737
GSE246335_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10294
BRD-K67998155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00071
PPIP5K1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13423
Pollen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.099
BRD-K47801291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0217
PHF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38196
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.6722
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.99625
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295471
GSE216538_7_v_2_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K35897342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55616
BRD-K45095313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09143
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K01639343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18293
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211866_2_v_1_usp11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.171
PMC6684323-NIHMS1532201-supplement-Table_S6.xlsx-LPS-Sup_Table_6C_Delta_PVE_among_PopDE_genes_LPS_PopDE_FDR_0_2_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9908924-41467_2023_36246_MOESM4_ESM.xlsx-Supplementary_data_2-DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE249544,GSE249637_9_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158431_5_v_1_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172028
GSE89018_1_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Familial cold autoinflammatory syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.604
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FEV	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1943
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7818
BRD-K51234905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5624
BRD-K77403813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46708
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201270,GSE201272_5_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CLMP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00509275
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.92
Blood vessel	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN014_HEPG2_3H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3239
GSE100102_4_v_3_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
HS695T	DepMap CRISPR Gene Dependency	1.0	9.255
Intercalated disc	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.986
FAM117B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01966
ZNF443	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46361
NCIH1666_LUNG	CCLE Cell Line Proteomics	1.0	2.04764
GSE205163,GSE205164_3_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
FKBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35734
CRCGN017_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.90565
PMC3376834-emmm0004-0052-SD2.xlsx-NR2E3_Specific_1847-Unnamed_1_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158815_5_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pollen tube	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.524
MYCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32642
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4705
BRD-K81821040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08158
NCIH1568_LUNG	CCLE Cell Line Proteomics	1.0	2.22323
Food allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.784
K562_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170242
PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3	Rummagene Transcription Factor Associations 2026	1.0	null
PPP4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05833
GSE180200,GSE180201_2_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K38788176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29818
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.612617
GSE180200,GSE180201_5_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70154746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19681
GSE215086_8_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3282
TIAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05063
GSE145215_0_v_1_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6870463-Table_7.xlsx-Family_H_LPS-LPS_treatment_of_BMDMs_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Latex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.132
GSE142210_2_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCNH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8181
A549_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150959
GSE229468,GSE229471_0_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
CFAP157	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2545
GSE161771_2_v_1_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
UBC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33506
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K02269304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37818
CHCHD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12961
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.98098
Crustacean allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.332
CDC5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78937
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.6328
BRD-K05392698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.554
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.386
GSE163862_2_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Rhinitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.296
Alveolar macrophage cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.824
GSE147664_0_v_1_arid1b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214505_0_v_1_akr1b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Neurod2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.1285
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1494
GSE101748_0_v_1_apela_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017127
BRD-K58208155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01113
BRD-A07195938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41981
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.0398
CRCGN015_HEPG2_48H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77135
IC-05-AW29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.383764
BRD-K00590556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26814
MCF7_Mocetinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00937088
BRD-K48749255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30709
K562_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124517
HUO9	DepMap CRISPR Gene Dependency	1.0	2.18774
BRD-K75041300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03186
BRD-K22606370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45048
BRD-K23342427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21481
MCF7_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.012736
PMC3636213-pgen.1003459.s012.xlsx-Sheet1-KD_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K14087001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28023
BRD-K84606053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1558
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218554
GSE171292_6_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K24883912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29194
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02476
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LHFPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22702
GSE152937_12_v_1_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115363_2_v_0_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4465
BRD-K88583132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20659
GSE251992_1_v_0_saracatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.354293
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5052
Breast Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
Trametinib (DMSO_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0152092
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
deubiquitinase activity	GO Molecular Function Annotations 2023	1.0	null
GSE219195_1_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K64509887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16252
GSE211177,GSE211178_0_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147943_5_v_1_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199606_5_v_7_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE255680_2_v_0_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PRTN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00541307
GSE216538_7_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A15454510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08827
PCI6A	DepMap CRISPR Gene Dependency	1.0	3.2843
BRD-K30977850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39586
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6733
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5668942-supp_gr.216721.116_Supplemental_Data_S2.xlsx-Artery_Tibial_IR-TE-SRCAP_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
GSE258991_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9	Rummagene Transcription Factor Associations 2026	1.0	null
Hypertrophic Cardiomyopathy	DisGeNET Gene-Disease Associations	1.0	null
Mhs	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.65
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NR1I2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00498643
GSE136742,GSE136744_0_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF211	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8262
CIB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28081
BRD-K01639528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08719
MEIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.574
CRCGN015_HEPG2_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38881
DYNLL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08778
CRCGN015_HEPG2_48H:I07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76735
GSE193258,GSE193259_9_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K37556799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34078
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-10q22_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112860_0_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9178
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203362_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE196962_2_v_6_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180200,GSE180201_3_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2116
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE93309_2_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154767_4_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:E18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08443
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ISGF3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.907
Heart - Atrial Appendage	GTEx Tissue Gene Expression Profiles 2023	1.0	1.23158
4064_IGF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.67354
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7394
CRCGN008_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1049
b69	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.765
GSE210505_0_v_1_sox1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2774
JUND	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59694
GSE241701_4_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23292
BRD-K11571815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20622
K562_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185404
GSE211226_1_v_2_sirpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COLO205_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.1609
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61466
Enhanceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.764
Asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.229
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Basal_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K25138450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13536
GSE195559_8_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.765
marc145	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.701
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	115.477
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ESRRG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01435
GSE88819_11_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
av3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.27
PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K48263613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43185
GSE231891_5_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223893_1_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TRAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01256
GSE92614_1_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.8889
FCGR1BP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00469921
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217006
PMC5989213-41467_2018_4462_MOESM9_ESM.xlsx-4-Supplementary_Data_4_Genes_differentially_expressed_in_SETBP1-G870S_vs_Empty_293_FLP-In_lines_whose_promoter_is_occupied_by_SETBP1-G870S_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K90111788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78317
K562_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147293
BRD-K18176829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51857
GSE157894_1_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE203308_15_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199899_3_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Immunoglobulin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.205
Mucosa-Associated Lymphoid Tissue Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
K562_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160859
OSC19	DepMap CRISPR Gene Dependency	1.0	3.61395
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nuclear membrane	GO Cellular Component Annotations 2023	1.0	null
GSE60691_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Sperm principal piece	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.692
BRD-K05304510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60237
Allergic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.201
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7071
IPO7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15205
CRCGN016_MCF10A.WT.HP_24H:I01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23765
BRD-K02630367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50086
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148510_1_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GPRIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70503
GSE201217_3_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013691
NLRP1 inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.496
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.58088
GSE154081_1_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K04409515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03591
GSE205550,GSE205552_2_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K12306640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35766
BRD-K57404319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38096
176_AFG3L2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.522149
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6126
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242306
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE194358,GSE194361_0_v_1_kdm5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Peanut allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.512
BRD-K85456600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28177
GSE248858_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0131
Inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.154
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7898
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
GSE161064,GSE161065_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K34595193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79505
HMGB1P1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33502
GSE241701_2_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	1.0	null
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2272
BRD-K61998715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43373
Collagen type I trimer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.853
BRD-K40548004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03902
176_AFG3L2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.501057
BRD-K98465548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28151
Fish allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.472
EZR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25941
GSE126345_7_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0249447
PMC3371315-NIHMS350140-supplement-12.xls-MCF7-T47D-SK-453_Down_Common_xl-Supplementary_Table_5_Luminal_Signature_Genes_decreased_in_all_four_cell_lines_MCF7_T47D_MB-453_SKBR3_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE155567_3_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145915_5_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95685_2_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE123825_2_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.507973
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0475
ZNF524	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15376
GSE227891_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K94480039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08982
BRD-K17176016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58835
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE196117_6_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
KYSE30_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	3.54316
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3457
GSE102757_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE167886_2_v_0_chd7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Quisinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0072234
GSE174701_4_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
UACC893	DepMap CRISPR Gene Dependency	1.0	4.39337
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.568536
IM9	DepMap CRISPR Gene Dependency	1.0	6.76232
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.905
BRD-K81960205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58672
GSE225218_0_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186280_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE151612_0_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dehydrodolichyl diphosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.488
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4368
GSE148066,GSE157787_0_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137736
Stomach Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
PMC11627398-pone.0315219.s005.xlsx-MTF1-symbol_MTF1	Rummagene Transcription Factor Associations 2026	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155724
BRD-K02689622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16609
GSE169571_5_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K38972344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46812
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
3916_HOXC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.604983
GSE249544,GSE249637_9_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K11844807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01944
BRD-K49864183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95281
K562_AT9283_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01651
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_1_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE101546_3_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11263707-41419_2024_6896_MOESM4_ESM.pdf-13-CREB3L4_CREB3L4	Rummagene Transcription Factor Associations 2026	1.0	null
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03736
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
ANKRD65	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06418
A-61603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27219
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1392
Nuclear envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Retrotransposon nucleocapsid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.933
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217990_0_v_1_rnmt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186486
BRD-K45076286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55932
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
BRD-K83547183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3147
PMC6225799-annrheumdis-2018-213524supp003.xlsx-Activated-state-LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.041
Lipopolysaccharide receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.952
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29765
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0233197
Astrocytoma	DisGeNET Gene-Disease Associations	1.0	null
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Microgametophyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.924
CRCGN011_HEPG2_24H:J04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03485
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
ETV5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.324
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8853
GSE206729_5_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Exoskeleton	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.096
BRD-K52037352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26985
BRD-K67120755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32023
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K33098168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1405
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K08205503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42285
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.70239
BRD-K22672200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81775
BRD-K84932026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4385
Chronic obstructive pulmonary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.161
COL2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.658
BRD-A31576716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27026
cysteine-type deubiquitinase activity	GO Molecular Function Annotations 2025	1.0	null
BRD-K55910052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57775
Interferon regulatory factor 7 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.802
CRCGN017_MCF10A.WT.HP_24H:K16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3869
GSE255680_2_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K94962552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0403
Nuclear membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
A549_Azacitidine_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122272
GAL3ST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24104
HS936T	DepMap CRISPR Gene Dependency	1.0	3.07719
BRD-K51104732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14148
Colon - Sigmoid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.14325
AD-28-GJ71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.450476
ZFX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10434
GSE221327_5_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195568_1_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05154886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53888
BRD-K85440939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25123
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GPN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28584
PMC12756533-mmc1.pdf-37-ZNF101_ZNF101	Rummagene Transcription Factor Associations 2026	1.0	null
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6687
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4915
CRCGN016_MCF10A.WT.HP_24H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00557
CRCGN015_HEPG2_48H:B12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58877
K562_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214705
BRD-K85909950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4881
GSE110268_0_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
cysteine-type peptidase activity	GO Molecular Function Annotations 2025	1.0	null
BRD-K65597286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12816
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.598
PRR14L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00376426
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K17897186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05764
LTB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00632207
CRCGN008_HEPG2_24H:E05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2123
GSE186483_6_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Obstructive lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.161
Organelle envelope	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.623
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143782_6_v_5_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETV2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6028
CRCGN017_MCF10A.TP53.M_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32925
BRD-K61886116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45935
BRD-K06355852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78997
GSE174701_4_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH838_LUNG	CCLE Cell Line Proteomics	1.0	12.4258
APH1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22989
GSE98831_1_v_0_brca1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151612_0_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ERF::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7982
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8433
Mean reticulocyte volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0699
TTC549	DepMap CRISPR Gene Dependency	1.0	2.29418
BRD-K86903429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03506
CRCGN015_HEPG2_48H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89176
A549_Danusertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111319
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.05151
BRD-K42995703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6684
butyrylcholine-cl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42732
16-HBE14o cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.866
GSE181461_1_v_4_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K37120019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58564
BRD-K27881972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32906
K562_PCI-34051_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150755
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112174_5_v_7_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5903_NUP93_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.02016
A549_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153631
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
ZNF530	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.1206
1716_CNOT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.52816
BRD-K91696235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03882
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.354045
BRD-K10010414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57764
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201217_4_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110178_2_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RERFGC1B	DepMap CRISPR Gene Dependency	1.0	4.32929
MCF7_Trichostatin A_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00610383
PMC9225015-elife-72879-supp6.tsv--DUB_HUGO_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-1912_ChIP-Seq_H3K9me1_2_demethylation_and_ChIP-Seq_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164757,GSE164759_4_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
NME6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00553169
SKN3	DepMap CRISPR Gene Dependency	1.0	2.55997
GSE60691_0_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
COL6A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05566
Ameloblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.522
CRCGN008_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44355
KIF23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40654
BRD-K36164005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17772
HSCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08177
MCF7_CYC116_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00974096
SCS214	DepMap CRISPR Gene Dependency	1.0	2.80118
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.161
BRD-K41189799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36494
EDS1 disease-resistance complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.796
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6658
BRD-K74651253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13806
ISCU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1285
BRD-K98061177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91602
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NLRP3 inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.737
GSE122378_0_v_1_carmil3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4905481-oncotarget-07-11397-s003.xlsx-Pinin_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K36228696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41151
BRD-K68884923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37899
MCF7_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01572
Six4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2086
BRD-K17185909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03938
GSE202744_1_v_0_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K25470159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05027
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K53095870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64807
Foxn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.8283
TBCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18651
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CA12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9781
BRD-K01759041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83903
BRD-K74918080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09443
PMC4224449-pone.0112193.s009.xlsx-PPI_MODULES_CLEAN_MAP_merg_OUT-Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K89501960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23247
ETS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0492
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:E22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16473
BRD-K04650671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00933
CINCA Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.141
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K86208187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21618
K562_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0255397
K562_JNJ-26854165_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186986
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.04437
BRD-K69387464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30134
GSE67266_5_v_3_etoposide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5286
GSE136742,GSE136744_2_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE100102_2_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217147
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.76225
CAL51_BREAST	CCLE Cell Line Proteomics	1.0	2.60753
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206219
GSE221327_6_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Fulvestrant_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109885
CRCGN017_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59437
CD46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16601
GSE202825_2_v_1_ano1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155628
CRCGN017_MCF10A.TP53.M_24H:E09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16744
GSE213588_9_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Costamere	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.922
BRD-K94616959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08762
GSE216538_0_v_2_mrs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27476515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0699
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Diisocyanate-induced asthma	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.6
GSE186483_1_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE155800_1_v_0_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RCC10RGB	DepMap CRISPR Gene Dependency	1.0	5.3625
GSE179036_1_v_0_trim24_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-EGR1_DC_ChIP-seq_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157094
BRD-K04635516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36354
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
CRCGN016_MCF10A.WT.HP_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35126
Phosphopyruvate hydratase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.846
BRD-K91341416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27176
EIF2S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67682
SUPT3H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02921
BRD-K47511177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83437
BRD-K85059356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01891
Nasal cavity disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.285
BRD-K15460257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89182
MCF7_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016588
GSE168797_4_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
SW1088	DepMap CRISPR Gene Dependency	1.0	2.92372
LIG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00502187
BRD-A20182314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2965
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4011
ZR751	DepMap CRISPR Gene Dependency	1.0	2.34272
amorolfine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00247
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4195
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16665
CD-16-KY17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204008
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.52086
BRD-K26108750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60241
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_Q1_vs_Q4-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30937829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41292
Zbtb2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	72.6693
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE89018_12_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MASP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00659501
GSE201239_6_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2693
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.31
GSE112860_0_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27953820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26344
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE174735_4_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196962_4_v_3_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
PMC8986528-41586_2022_4598_MOESM11_ESM.xlsx-Extended_Data_Fig_6l-NOL9_KD_upreg_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
OXCT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52027
GSE123022,GSE123030_8_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE91015_0_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
K562_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153294
LZTS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00644501
CDC42EP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58268
ICC2	DepMap CRISPR Gene Dependency	1.0	2.24366
BRD-K99125195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86493
CRCGN017_MCF10A.WT.HP_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39352