association	dataset	threshold value	standardized value
rab22a	GeneRIF Biological Term Annotations	1.0	null
oncogene	GeneRIF Biological Term Annotations	1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37595
EZH2	ENCODE Transcription Factor Targets	1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.941598
decreases	GeneRIF Biological Term Annotations	1.0	null
MDAPCA2B	CCLE Cell Line Gene CNV Profiles	1.0	1.36182
COLO-704	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04409
ECC10	CCLE Cell Line Gene CNV Profiles	1.0	1.50858
demonstrated	GeneRIF Biological Term Annotations	1.0	null
KPL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.53386
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.999252
H3K9me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08923
OCI-AML3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29512
JHH4	CCLE Cell Line Gene CNV Profiles	-1.0	-2.28447
invasion	GeneRIF Biological Term Annotations	1.0	null
19924232-TableS1	GeneSigDB Published Gene Signatures	1.0	null
cycle	GeneRIF Biological Term Annotations	1.0	null
PC3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71147
NCIH2122	CCLE Cell Line Gene CNV Profiles	1.0	2.02324
IM-95M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29512
G59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40584
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26353
targeting	GeneRIF Biological Term Annotations	1.0	null
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32696
HCC366	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47382
BC3C	CCLE Cell Line Gene CNV Profiles	1.0	1.61917
TP63	ChEA Transcription Factor Targets	1.0	null
useful	GeneRIF Biological Term Annotations	1.0	null
OCUM1	CCLE Cell Line Gene CNV Profiles	1.0	1.43283
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43988
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.849162
irf1	GeneRIF Biological Term Annotations	1.0	null
SOX4	MotifMap Predicted Transcription Factor Targets	1.0	null
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.25878
HCC202	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54695
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.868481
WSU-DLCL2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29512
decreased	GeneRIF Biological Term Annotations	1.0	null
inversely	GeneRIF Biological Term Annotations	1.0	null
EVSAT	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.849162
ONCODG1	CCLE Cell Line Gene CNV Profiles	1.0	1.76169
exhibit	GeneRIF Biological Term Annotations	1.0	null
tumors	GeneRIF Biological Term Annotations	1.0	null
phase	GeneRIF Biological Term Annotations	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.86119
colon	GeneRIF Biological Term Annotations	1.0	null
AP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.852072
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.6202
BT549	CCLE Cell Line Gene CNV Profiles	1.0	1.54458
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	2.88009
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.962695
upregulation	GeneRIF Biological Term Annotations	1.0	null
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.86119
methylation	GeneRIF Biological Term Annotations	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.94512
HCC1171	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71273
pathological	GeneRIF Biological Term Annotations	1.0	null
NUGC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.849162
KURAMOCHI	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36236
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.897156
controlling	GeneRIF Biological Term Annotations	1.0	null
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29512
negative	GeneRIF Biological Term Annotations	1.0	null
KCL22	CCLE Cell Line Gene CNV Profiles	1.0	1.8605
gliomas	GeneRIF Biological Term Annotations	1.0	null
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29595
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06071
MKN7	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5492
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.883264
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0529
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41349
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20877
SJSA1	CCLE Cell Line Gene CNV Profiles	1.0	1.383
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.941598
SW1417	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69776
apoptosis	GeneRIF Biological Term Annotations	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03217
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32745
IM-95	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46122
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
gammah2ax	GeneRIF Biological Term Annotations	1.0	null
SU-DHL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22821
CHK2_KD_GSE54268_667_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
downregulated	GeneRIF Biological Term Annotations	1.0	null
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.61814
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.843771
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26404
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29512
elevated	GeneRIF Biological Term Annotations	1.0	null
acts	GeneRIF Biological Term Annotations	1.0	null
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.915576
HCC2814	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40826
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00345
suppressor	GeneRIF Biological Term Annotations	1.0	null
OVCAR-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.995004
SNU245	CCLE Cell Line Gene CNV Profiles	1.0	1.43013
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60515
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50953
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43938
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60515
USF2	ENCODE Transcription Factor Targets	1.0	null
arrest	GeneRIF Biological Term Annotations	1.0	null
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54706
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
L1236	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32931
under	GeneRIF Biological Term Annotations	1.0	null
proliferation	GeneRIF Biological Term Annotations	1.0	null
igf1r	GeneRIF Biological Term Annotations	1.0	null
mir383	GeneRIF Biological Term Annotations	1.0	null
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11427
prdx3	GeneRIF Biological Term Annotations	1.0	null
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26404
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08934
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33446
functions	GeneRIF Biological Term Annotations	1.0	null
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.961977
regulating	GeneRIF Biological Term Annotations	1.0	null
TCF4	MotifMap Predicted Transcription Factor Targets	1.0	null
strategy	GeneRIF Biological Term Annotations	1.0	null
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
aberrant	GeneRIF Biological Term Annotations	1.0	null
EVSA-T	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.61078
OCI-AML5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46156
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.91767
COLO684	CCLE Cell Line Gene CNV Profiles	1.0	1.48595
SW1116	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67775
SNU61	CCLE Cell Line Gene CNV Profiles	-1.0	-1.70861
JHH-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.75017
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32745
GR	MotifMap Predicted Transcription Factor Targets	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
BRCA1	JASPAR Predicted Transcription Factor Targets	1.0	null
knocks	GeneRIF Biological Term Annotations	1.0	null
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08969
foxa1_23539448_lncap_lof_human_gpl10558_gse37314	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.519628
SW 480	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10508
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23168
cisplatin	GeneRIF Biological Term Annotations	1.0	null
COLO783	CCLE Cell Line Gene CNV Profiles	1.0	2.13325
KYSE-50	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.61078
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.916329
EBF	MotifMap Predicted Transcription Factor Targets	1.0	null
MDAMB361	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68874
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
HT29	CCLE Cell Line Gene CNV Profiles	-1.0	-2.09765
regulator	GeneRIF Biological Term Annotations	1.0	null
glioma	GeneRIF Biological Term Annotations	1.0	null
HCC70	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.61078
grades	GeneRIF Biological Term Annotations	1.0	null
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.911597
promotes	GeneRIF Biological Term Annotations	1.0	null
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09886
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.849162
COLO680N	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41507
inducing	GeneRIF Biological Term Annotations	1.0	null
developing	GeneRIF Biological Term Annotations	1.0	null
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37595
inhibits	GeneRIF Biological Term Annotations	1.0	null
part	GeneRIF Biological Term Annotations	1.0	null
KMS34	CCLE Cell Line Gene CNV Profiles	1.0	1.81024
DV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29512
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07366
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08969
ccnd1	GeneRIF Biological Term Annotations	1.0	null
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.73948
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26353
TYK-NU.CP-R	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.897156
medulloblastoma	GeneRIF Biological Term Annotations	1.0	null
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72196
SNU449	CCLE Cell Line Gene CNV Profiles	1.0	1.3537
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.886524
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.871719
formation	GeneRIF Biological Term Annotations	1.0	null
UKE-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.46433
H3K9me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
down	GeneRIF Biological Term Annotations	1.0	null
treatment	GeneRIF Biological Term Annotations	1.0	null
summary	GeneRIF Biological Term Annotations	1.0	null
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20926
DANG	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59928
JHH-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.875814
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.999971
PPARD	ChEA Transcription Factor Targets	1.0	null
NCI-H2135	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01489
NCIH211	CCLE Cell Line Gene CNV Profiles	1.0	1.57462
MOLM13	CCLE Cell Line Gene CNV Profiles	1.0	1.46618
GATA3	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me1_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SNU620	CCLE Cell Line Gene CNV Profiles	1.0	1.40037
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.849162
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
KYSE70	CCLE Cell Line Gene CNV Profiles	1.0	1.87932
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.96919
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29512
directly	GeneRIF Biological Term Annotations	1.0	null
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23168
pnuts	GeneRIF Biological Term Annotations	1.0	null
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26353
NCIH209	CCLE Cell Line Gene CNV Profiles	1.0	2.34314
critical	GeneRIF Biological Term Annotations	1.0	null
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16849
focal	GeneRIF Biological Term Annotations	1.0	null
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40798
NIHOVCAR3	CCLE Cell Line Gene CNV Profiles	1.0	1.84945
demonistrated	GeneRIF Biological Term Annotations	1.0	null
EFM19	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40966
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
USF2_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20926
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29512
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.69909
G292CLONEA141B1	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
correlated	GeneRIF Biological Term Annotations	1.0	null
18308931-Table3	GeneSigDB Published Gene Signatures	1.0	null
report	GeneRIF Biological Term Annotations	1.0	null
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.849162
suggested	GeneRIF Biological Term Annotations	1.0	null
mirna	GeneRIF Biological Term Annotations	1.0	null
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05869
ECGI10	CCLE Cell Line Gene CNV Profiles	-1.0	-1.9908
AR	ChEA Transcription Factor Targets	1.0	null
JHOS-4	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.61078
therapeutic	GeneRIF Biological Term Annotations	1.0	null
SKNMC	CCLE Cell Line Gene CNV Profiles	1.0	2.14421
HS 940.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22821
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.949521
least	GeneRIF Biological Term Annotations	1.0	null
JHOS4	CCLE Cell Line Gene CNV Profiles	-1.0	-2.17771
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.9914
MEG01	CCLE Cell Line Gene CNV Profiles	1.0	1.52557
downregulationinduced	GeneRIF Biological Term Annotations	1.0	null
SW1271	CCLE Cell Line Gene CNV Profiles	-1.0	-1.84491
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54706
EP300_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
deltaEF1	MotifMap Predicted Transcription Factor Targets	1.0	null
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.875814
AR-22383394-PROSTATE_CANCER-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
HCC70	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59447
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.871719
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.94512