association dataset threshold value standardized value D283MED CCLE Cell Line Gene CNV Profiles -1.0 -2.01742 mRNA_T_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null GSE158815_1_v_3_trib1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE100464,GSE100465_0_v_3_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null HCC1806 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.6571 SIK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52137 CEBPB_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_11173_Mut_Ctbp2_SRP188140 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.11967 GSE80222_1_v_0_ezh2_mouse RummaGEO Gene Perturbation Signatures 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.600479 pancreatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.138917 medial part of r4B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18664 short insular gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.885899 GSE153836_14_v_1_fluoxetine_mouse RummaGEO Drug Perturbation Signatures -1.0 null F36P Achilles Cell Line Gene Essentiality Profiles 1.0 1.94178 RNA helicase p68_KD_GDS2152_625_mouse_skeletal muscle cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null SNU-C5 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4132-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null positive regulation of protein modification process GO Biological Process Annotations 2015 1.0 null KMS-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.56525 Field CA2, stratum radiatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1189 Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.15 PRKACA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28144 MOLM13 Achilles Cell Line Gene Essentiality Profiles 1.0 1.0334 GSE139016_0_v_1_disulfiram_human RummaGEO Drug Perturbation Signatures 1.0 null positive regulation of cell communication GO Biological Process Annotations 2015 1.0 null WM-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07282 CTCF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPARGC1A_NULL MUTATION_GDS2149_721_mouse_Brown adipocyte GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE113106_2_v_1_dnm2_mouse RummaGEO Gene Perturbation Signatures -1.0 null mRNA_KLF4_18264089 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE237040_6_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.882877 GSE227592_13_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null Urinary system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Lung bud TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.613 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null alitretinoin_homo sapiens_gpl6480_gse43090 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FAM91A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63405 anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.40657 Dorsal part of the lateral geniculate complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12258 CTCF_BE2C_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE242199_9_v_5_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null Weight Gain CTD Gene-Disease Associations 1.0 1.58537 cell part GO Cellular Component Annotations 2015 1.0 null PMC2883591-pgen.1000979.s003.xls-NRSF_GENELISTS_WitOut_GeneSig_g-Supplemental_Table_3_REST Rummagene Transcription Factor Associations 2026 1.0 null intercalate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38186 external segment of globus pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.143 PMC6853299-pbio.3000476.s011.xlsx-Fig_4A-RA_812_genes_expression_ratio_in_ZF_and_OF_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null NCI-H1623 COSMIC Cell Line Gene CNV Profiles 1.0 2.09073 GPSM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20164 MED7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21627 Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01017 Hoxa13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.7181 SK-N-AS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07282 TBX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00168 PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4 Rummagene Transcription Factor Associations 2026 1.0 null 496100538_HIP_no dementia_no TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.42715 IX Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.29328 basomedial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.838172 Hippocampal formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26484 CTCF_GM12866_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GJC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46256 r3 part of reticulotegmental nucleus, shell portion Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21927 MDAMB157 DepMap CRISPR Gene Dependency 1.0 2.0936 MONOMAC1 DepMap CRISPR Gene Dependency 1.0 2.74297 superficial stratum of r3Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2747 H3K27ac_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CCM2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74786 pituitary GTEx Tissue Gene Expression Profiles 1.0 1.30187 OB mitral cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21823 H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null r8 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19366 nucleus accumbens, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.57364 Anterolateral visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20228 Uterine Neoplasms CTD Gene-Disease Associations 1.0 1.10104 macrophage TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.446038 ursodeoxycholic acid_mus musculus_gpl6246_gse22608 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null caudal division of IPC (area 39) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.49197 GSE132386_1_v_0_ppara_mouse RummaGEO Gene Perturbation Signatures 1.0 null POU5F1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.9876 HCC2935 CCLE Cell Line Gene CNV Profiles 1.0 1.51309 Organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 OV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.01066 kinase activity GO Molecular Function Annotations 2015 1.0 null PMC4060771-170289.f1.pdf-201-MLL_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null medial (magnocellular) part of MD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18196 H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null HCA1 DepMap CRISPR Gene Dependency 1.0 2.72812 Inferior mesenteric artery TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.144 PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-combined_portrait-EGR1_1_EGR1 Rummagene Transcription Factor Associations 2026 1.0 null intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null hsa-miR-346 TargetScan Predicted Conserved microRNA Targets 1.0 0.714812 PMC6607928-iovs-60-07-32_file_S11.xlsx-no_change_NRL_mutants-human_gene_ortholog_NRL Rummagene Transcription Factor Associations 2026 1.0 null phosphate-containing compound metabolic process GO Biological Process Annotations 2015 1.0 null H3K27me3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HT1197 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.09345 spinal cord TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CHD2 ENCODE Transcription Factor Targets 1.0 null Kidney Diseases CTD Gene-Disease Associations 1.0 1.27782 Presubiculum, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38871 HROB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58456 PRSS27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9342 GSE126345_7_v_10_hcrt_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE237040_0_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-3910 TargetScan Predicted Conserved microRNA Targets 1.0 0.598666 V, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.897832 ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.30435 LN215 CCLE Cell Line Gene Expression Profiles 1.0 1.60745 GSE210580_0_v_12_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.908061 H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null parvicellular (lateral) subparafascicular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14328 NCIH2171 CCLE Cell Line Gene Expression Profiles 1.0 1.50965 ZFP281-18757296-E14-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null bile duct disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.062892 RCOR1 ENCODE Transcription Factor Targets 1.0 null Primary somatosensory area, trunk Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15127 ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.16338 SLC25A11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19073 ZNF320 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 333.386 NUGC4 CCLE Cell Line Gene CNV Profiles 1.0 1.59531 crohn disease; crohn's disease GAD Gene-Disease Associations 1.0 null cellular macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null GSE88819_7_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PLAGL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.6561 plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.128079 Bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.2941 NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.35742 P30-OHK COSMIC Cell Line Gene Mutation Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-AG-3742-11A-01R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null golgi membrane GO Cellular Component Annotations 2015 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A5XV-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE217541,GSE217543_3_v_2_tet1_human RummaGEO Gene Perturbation Signatures -1.0 null Perinuclear region of cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 hsa-miR-4288 TargetScan Predicted Conserved microRNA Targets 1.0 0.187098 internal female genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05207 ZNF93 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 133.696 mediodorsal nucleus of thalamus_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.33037 Dmrt1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.2001 Fields of Forel Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25771 TMEM79 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65725 GSE242199_9_v_3_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null Weight Loss CTD Gene-Disease Associations 1.0 1.42047 premotor cortex (area 6) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.39649 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.71108 U118MG DepMap CRISPR Gene Dependency 1.0 2.48679 Lung adenocarcinoma_LUAD_TCGA-75-5146-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IV, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.25611 protein modification process GO Biological Process Annotations 2015 1.0 null NFIC JASPAR Predicted Transcription Factor Targets 1.0 null GSE131887_1_v_4_doxycycline_mouse RummaGEO Drug Perturbation Signatures -1.0 null BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.902799 Muscle tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.258 496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.06761 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null regulation of protein modification process GO Biological Process Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7877-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MOLT3 CCLE Cell Line Gene CNV Profiles -1.0 -1.65936 PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-female_port-FOS_1_FOS Rummagene Transcription Factor Associations 2026 1.0 null COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02131 POTEE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12049 Ebolavirus(EBOV)_3day_PBMCs_17725815_GSE8317 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.88369 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050281 Stomach TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 OCIMY5 CCLE Cell Line Gene CNV Profiles -1.0 -1.51372 hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.975904 HIVEP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28295 Tongue cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.683 RAD21 ENCODE Transcription Factor Targets 1.0 null cellular_component GO Cellular Component Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-5870-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE190534,GSE190536_0_v_1_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null superficial stratum of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.53932 Prostate adenocarcinoma_PRAD_TCGA-VP-A878-01A-31R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A7J2-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null positive regulation of nervous system development GO Biological Process Annotations 2015 1.0 null Fibrosis CTD Gene-Disease Associations 1.0 1.32637 hematopoietic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.067604 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null Velum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.537 H3K27ac_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hilus of the DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.18589 regulation of small gtpase mediated signal transduction GO Biological Process Annotations 2015 1.0 null regulation of cellular process GO Biological Process Annotations 2015 1.0 null Central linear nucleus raphe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00695 SDR39U1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52272 GSE210580_0_v_11_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 t60-adrenal_consensus MoTrPAC Rat Endurance Exercise Training 1.0 8.90304 Heart Diseases CTD Gene-Disease Associations 1.0 1.18126 P31FUJ CCLE Cell Line Gene CNV Profiles -1.0 -1.9079 p3 part of the ZL core Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11632 GSE220520_3_v_7_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mature cataract DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.501 hsa-miR-2355-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RXF393 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE129389_0_v_1_tropifexor_mouse RummaGEO Drug Perturbation Signatures -1.0 null MATR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7278 perinuclear region of cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 CORL279 CCLE Cell Line Gene Expression Profiles -1.0 -1.95922 X-organ-sinus-gland complex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.082 Perturb_10787_KO_Shp_SRP220815 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 18.2757 posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.77213 H3K27me3_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DPYSL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33538 RNH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77208 positive regulation of neuron differentiation GO Biological Process Annotations 2023 1.0 null Semicircular canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.6 Alimentary canal TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 MAP3K20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35766 hippocampus (cortex Ammonis) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25856 HCC1806 CCLE Cell Line Gene CNV Profiles 1.0 1.59856 lmo4_17452977_mcf7_lof_human_gpl570_gds2789 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.455188 mRNA_MEF2C_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Oligodendroglioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.145 CTCF ENCODE Transcription Factor Targets 1.0 null periventricular stratum of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01636 TMX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61743 KMS27 CCLE Cell Line Gene Expression Profiles 1.0 1.71434 RFC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72842 POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW1088 DepMap CRISPR Gene Dependency 1.0 5.04391 hsa-miR-4642 TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 TCFCP2L1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null RPS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23394 ABT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54274 GSE144231_6_v_7_cxcr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null LY2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.602761 ventrolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.946964 hsa-miR-3147 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.329 TM2D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54411 layer 4 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06117 posteroventral (inferior) parietal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.02251 Memory Disorders CTD Gene-Disease Associations 1.0 1.06588 GSE214596,GSE214598_1_v_4_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE69244_1_v_0_j147_mouse RummaGEO Drug Perturbation Signatures 1.0 null NR2C2AP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.19271 SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13343 superficial stratum of CA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26035 H3K4me3_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.32681 TOX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95024 DAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10721 STK38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97623 MZ7-MEL COSMIC Cell Line Gene Mutation Profiles 1.0 null STAT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.2552 ELAC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0002 hsa-miR-4308 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 Primary somatosensory area, trunk, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43674 GSE138815,GSE138817_3_v_1_kdm6a_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE92364_0_v_5_asparaginase_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K27me3_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner CP in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.903037 Muscular Atrophy HuGE Navigator Gene-Phenotype Associations 1.0 null Perturb_14212_KO_Sp8/Sp8_SRP095936 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 toxoplasmosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.526518 H3K4me3_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.976532 T-lymphoblastoid cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.587 indispensable GeneRIF Biological Term Annotations 1.0 null raphe magnus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18725 E2F6 JASPAR Predicted Transcription Factor Targets 1.0 null SECISBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04979 GSE182835,GSE182836_0_v_1_siah2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC8905236-mmc2.xlsx-Table_S10-Table_S10_Differentially_regulated_genes_in_SPI1_high_vs_low_group_in_CGGA_GBM_dataset_SPI1 Rummagene Transcription Factor Associations 2026 1.0 null Ebf2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.7094 parietal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.832571 NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38584 GAMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41494 primary auditory cortex (core)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.35713 POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE68156_3_v_5_dextran_mouse RummaGEO Drug Perturbation Signatures 1.0 null AN3-CA COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null positive regulation of ras protein signal transduction GO Biological Process Annotations 2015 1.0 null outer CP in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.830583 Endomembrane system COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 TE4 CCLE Cell Line Gene Expression Profiles -1.0 -1.54781 hsa-miR-2861 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Field CA2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00558 hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.886519 MYC ENCODE Transcription Factor Targets 1.0 null H3K27me3_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null regulation of developmental process GO Biological Process Annotations 2015 1.0 null GSE160373_1_v_4_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null LTBR_INHIBITION - 3 Days_GDS2005_730_mouse_Lymph nodes (MG-430B) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null UMRC6 CCLE Cell Line Gene Expression Profiles 1.0 1.77553 SENP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33582 GALR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4423 MDAMB436 CCLE Cell Line Gene CNV Profiles 1.0 1.85996 GSE157555,GSE157556_4_v_2_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null dorsolateral prefrontal cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00442 Neuromast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.91 SKBR3 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.31824 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Golgi apparatus COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 C3A CCLE Cell Line Gene Expression Profiles 1.0 1.49407 Kidney Chromophobe_KICH_TCGA-KN-8437-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Subiculum, dorsal part, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61085 rhombomere 11 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3323 Vagina GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.538116 ZNF148 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 120.048 MIAPACA2 Achilles Cell Line Gene Essentiality Profiles 1.0 1.12935 H2AFZ ENCODE Transcription Factor Targets 1.0 null NCI-H2087 COSMIC Cell Line Gene Mutation Profiles 1.0 null Adenocarcinoma CTD Gene-Disease Associations 1.0 1.09047 primary auditory cortex (core)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.1095 RBM19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.15643 CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null XBP1_OE_GDS5065_273_mouse_F424a adipocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K27me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5187-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null leukemia cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.356314 GSE205163,GSE205164_1_v_6_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null KLF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 81.8316 SPRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90691 Nucleus ambiguus, dorsal division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2744 hsa-miR-613 TargetScan Predicted Conserved microRNA Targets 1.0 0.49473 GSE202175_1_v_2_triptolide_mouse RummaGEO Drug Perturbation Signatures -1.0 null Intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 NCIH929 CCLE Cell Line Gene CNV Profiles -1.0 -1.84838 GSE94814_2_v_3_reck_mouse RummaGEO Gene Perturbation Signatures 1.0 null Carbohydrate metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.049 CORL24 CCLE Cell Line Gene Expression Profiles 1.0 1.39893 H3K27me3_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_9483_KO_Fnip1_SRP339469 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.69873 H3K27me3_cardiac mesoderm_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE160373_8_v_2_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE160373_1_v_2_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null Medial geniculate complex, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22425 Carcinoma, Hepatocellular CTD Gene-Disease Associations 1.0 1.27378 superficial stratum of r1Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27963 posteroventral (inferior) parietal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.37273 CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9170821-JCMM-26-3183-s001.xlsx-Neu_DAPI_ERG_VaD_vs_NC-Gene_ERG Rummagene Transcription Factor Associations 2026 1.0 null TE15 Achilles Cell Line Gene Essentiality Profiles 1.0 1.87241 MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.41798 H3K27me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-509-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 NR3C1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.312 MAP7D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00905 Rectum adenocarcinoma_READ_TCGA-DY-A0XA-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MOLT4 CCLE Cell Line Gene CNV Profiles -1.0 -1.8076 T84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24013 Autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.125 PMC11951866-mmc1.pdf-20-ZNF462_ZNF462 Rummagene Transcription Factor Associations 2026 1.0 null H3K27me3_erythroblast_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null caudal linear (raphe) nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3943 GSE101239_5_v_0_valproic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.23083 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.841261 positive regulation of protein phosphorylation GO Biological Process Annotations 2023 1.0 null GSE119498_6_v_4_setd5_mouse RummaGEO Gene Perturbation Signatures -1.0 null SAS cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.948 FKBP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68468 Perturb_10865_KO_Hsf1_SRP116890 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.83993 LN428 CCLE Cell Line Gene Expression Profiles 1.0 1.52496 PMC11801220-NIHMS2038999-supplement-16.xlsx-Exc-MAF-gene_MAF Rummagene Transcription Factor Associations 2026 1.0 null mRNA_NR5A2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.15013 HIPK2_defectivemutant_17_GDS1793 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.65182 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4635-01A-02R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC6607928-iovs-60-07-32_file_S11.xlsx-no_change_NRL_mutants-earlyfoetal_NRL Rummagene Transcription Factor Associations 2026 1.0 null Central cylinder COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.791 Perturb_4467_KO_Cnr1_SRP346447 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.0814 H3K27me3_mononuclear cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35869 GOLGA8A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18596 macrophage cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.459532 miyoshi muscular dystrophy 2 OMIM Gene-Disease Associations 1.0 null H3K27me3_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_10779_KO_Slc25a34_SRP342539 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.11568 RBBP5 ENCODE Transcription Factor Targets 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7875-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZKSCAN5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.324 Liver Cirrhosis CTD Gene-Disease Associations 1.0 1.01099 NCIH1836 DepMap CRISPR Gene Dependency 1.0 2.90592 hsa-miR-4496 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 hippocampus (hippocampal formation)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.07208 Hypertrophy CTD Gene-Disease Associations 1.0 1.46172 H3K27me3_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051098 GSE101239_4_v_2_valproic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null PARN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72239 Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.091 HCC1954 Achilles Cell Line Gene Essentiality Profiles 1.0 1.24954 mRNA_NANOG_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null smarcc2_00000000_e12dot5_embryonic_cortex_lof_mouse_gpl6887_gse45629 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.957198 Brain Lower Grade Glioma_LGG_TCGA-DU-8164-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null IPO9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22091 GSE142684_2_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null HJURP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45453 SLC35E1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19566 THBS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5787 AGFG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0789 inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.76858 VBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71781 IM-95 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.963872 H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null paracentral lobule, posterior part, left, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.825765 RPL35A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55306 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.40414 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.32765 Sarcoma_SARC_TCGA-HS-A5N8-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsal part of CoP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40872 MDAMB468 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -2.32676 Field CA1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15823 raw-264.7 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.542566 GSE210580_0_v_1_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE102675_3_v_0_atf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE181517_2_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null ZBTB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.02947 OSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87173 primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.49856 H4K20me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE191138_2_v_4_fmo3_mouse RummaGEO Gene Perturbation Signatures -1.0 null CHERP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 6.34711 etoposide_mus musculus_gpl6887_gse33626 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CORL47 DepMap CRISPR Gene Dependency 1.0 5.00657 ATXN7L3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59602 hsa-miR-429 TargetScan Predicted Conserved microRNA Targets 1.0 0.828473 primary auditory cortex (core)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.844904 intermediate stratum of CoPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02623 GSE125007,GSE125008_6_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.909624 Foxj2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.9776 NFKB1 JASPAR Predicted Transcription Factor Targets 1.0 null hsa-miR-124 TargetScan Predicted Conserved microRNA Targets 1.0 0.119151 occipital pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12093 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3358-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE129241_4_v_2_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null mononuclear cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.131848 SLC38A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.58192 RAB41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.15397 PMPCA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13779 GSE199644_3_v_2_palmitic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null CCNH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8181 CP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.44363 regulation of signaling GO Biological Process Annotations 2015 1.0 null Hypertension CTD Gene-Disease Associations 1.0 1.05573 Lung squamous cell carcinoma_LUSC_TCGA-56-8083-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 19605494-TableS2 GeneSigDB Published Gene Signatures 1.0 null Hand1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.9652 interpeduncular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09483 EP300_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRPS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01231 Perturb_14107_KO_Setd2_SRP220107 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.56788 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1Z3-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE86507,GSE86509_3_v_10_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050724 H3K27me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EXOSC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02704 ZNF232 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19217 COV644 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24013 TTC31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41577 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.919871 SLC16A8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06694 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.54625 GSE205976,GSE205978_2_v_4_cep83_human RummaGEO Gene Perturbation Signatures -1.0 null medial geniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28183 primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.30984 Crohn Disease HuGE Navigator Gene-Phenotype Associations 1.0 null RAB7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56168 Subiculum, dorsal part, stratum radiatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26935 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4960-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-764 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 dorsal terminal nucleus of the accessory optic tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44691 hsa-miR-326 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 KLF17 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.9428 GSE157960_0_v_3_progesterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null HUH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.858947 Kidney Chromophobe_KICH_TCGA-KN-8435-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HSPB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60684 crohn's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.442042 GPT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27786 Field CA3, stratum pyramidale Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55719 head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051743 positive regulation of cellular metabolic process GO Biological Process Annotations 2015 1.0 null HDHD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.223 LRFN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26559 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4335-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Thoracic ganglion TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.696 GSE216273,GSE216292_0_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null WBP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.47311 GSE237040_2_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null regulation of neuron differentiation GO Biological Process Annotations 2025 1.0 null protein metabolic process GO Biological Process Annotations 2015 1.0 null CMTM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67707 HS852T DepMap CRISPR Gene Dependency 1.0 5.81662 KAT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10686 CYSRT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57617 dorsolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.912169 inner CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.833529 Perturb_10788_KO_Shp_SRP220815 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 9.43896 GSE242199_6_v_3_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_17278_KO_Upf2_SRP038144 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 ZBTB6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.9937 TMEM35A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31123 GSE196699_0_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null Type 2 diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.008 POU2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.517 layer I of piriform cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.881321 MS751 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.6456 NDUFS7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2323 18614019-TableS4d GeneSigDB Published Gene Signatures 1.0 null PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCallEPC1-PHF1_H3K27me3_k562-ENSEMBL_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null CERS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32864 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 PITX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.2365 HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02131 PPIA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31142 Ammon's horn Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32947 SNU761 CCLE Cell Line Gene CNV Profiles 1.0 1.91122 496100294_HIP_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.13174 PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_LF_species_not_found_in_common_genes_of_R_species_LTF Rummagene Transcription Factor Associations 2026 1.0 null intracellular part GO Cellular Component Annotations 2015 1.0 null GSE144231_2_v_7_cxcr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null r2 part of principal trigeminal sensory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47887 intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null Lhx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 37.6 GSE216413_1_v_0_gata3_human RummaGEO Gene Perturbation Signatures -1.0 null midbrain reticular formation Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17976 DOK COSMIC Cell Line Gene CNV Profiles 1.0 2.09073 Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DM-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RCC4 CCLE Cell Line Gene Expression Profiles 1.0 1.54204 Epididymal white adipose tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.792 SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.967804 496100631_PCx_dementia_TBI_77_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.78423 primary motor cortex (area M1, area 4)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.73686 CTCF_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abducens nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16418 retina BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.848969 H4K20me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ChIP_EZH2_18974828 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A217-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE207914_4_v_7_nudt7_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE217873_1_v_0_nusap1_human RummaGEO Gene Perturbation Signatures 1.0 null CNNM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34357 integral component of membrane GO Cellular Component Annotations 2015 1.0 null NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.21058 primary auditory cortex (core)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.39857 Perturb_10856_KO_Shp_SRP220815 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.63919 golgi apparatus part GO Cellular Component Annotations 2015 1.0 null Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.252 F36P CCLE Cell Line Gene CNV Profiles -1.0 -1.38979 CAOV4 DepMap CRISPR Gene Dependency 1.0 2.62062 posteroventral (inferior) parietal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.878458 regulation of localization GO Biological Process Annotations 2015 1.0 null Diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.044 Inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.098 hsa-miR-3064-5p TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 stomach HPA Tissue Protein Expression Profiles 1.0 0.955548 PERP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41486 Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.45103 Miyoshi Muscular Dystrophy 2 CTD Gene-Disease Associations 1.0 2.88009 regulation of Ras protein signal transduction GO Biological Process Annotations 2025 1.0 null TCIRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0208 VCAN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.15045 hsa-miR-4784 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 496100629_HIP_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.15705 caudal prosubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.66025 muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.254183 paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.38412 CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 184B5 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.853869 H3K27me3_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JEG3 DepMap CRISPR Gene Dependency 1.0 2.52823 occipital pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.69661 ZNF182 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25697 SNU1033 CCLE Cell Line Gene Expression Profiles -1.0 -1.65586 Infertility, Female CTD Gene-Disease Associations 1.0 1.03345 dorsolateral prefrontal cortex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.13727 positive regulation of kinase activity GO Biological Process Annotations 2023 1.0 null GSE227592_13_v_1_adar_human RummaGEO Gene Perturbation Signatures -1.0 null Subiculum, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09841 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MFE319 CCLE Cell Line Gene CNV Profiles -1.0 -1.92868 SOX2 ChEA Transcription Factor Targets 1.0 null Nucleus of the optic tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.462 localization GeneRIF Biological Term Annotations 1.0 null Perturb_11158_KO_Mdr2_SRP070832 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 H3K27me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null medial habenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08098 glioma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null RB1_KD_GSE50532_657_human_OSTEOBLASTS GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null STAG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54334 VIIAt Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.877732 CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null brain GTEx Tissue Gene Expression Profiles 1.0 1.57345 membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.043861 GSE247084,GSE247087_0_v_1_cdyl_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE138001_0_v_3_rorb_mouse RummaGEO Gene Perturbation Signatures -1.0 null 95T1000 DepMap CRISPR Gene Dependency 1.0 2.16517 hsa-miR-483-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Perturb_15296_KO_Ash2l_SRP212178 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.4233 EIF5A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90811 layer 2 of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1396 SJSA1 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.09445 Glucose metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.029 Primary somatosensory area, upper limb, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47634 NIHOVCAR3 CCLE Cell Line Gene CNV Profiles -1.0 -2.3514 PREP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42735 IMR32 CCLE Cell Line Gene Expression Profiles 1.0 2.00919 H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ETV7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5146 X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.638 hippocampus BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.64582 TFCP2L1 ChEA Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-33-4533-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE129370_2_v_3_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null Field CA1, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01331 REH Achilles Cell Line Gene Essentiality Profiles 1.0 1.71222 CTCF_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_2day-MOI-10^4_None_GSE43301 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.49698 regulation of transferase activity GO Biological Process Annotations 2015 1.0 null CAR-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02131 SW1116 CCLE Cell Line Gene Expression Profiles 1.0 1.46209 GSE232223_1_v_0_letmd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null OV7 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.03084 SP5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.6219 PMC7940623-41467_2021_21725_MOESM11_ESM.xlsx-Extended_data_table_9_regulons-FOS_extended_FOS Rummagene Transcription Factor Associations 2026 1.0 null Fatty Liver CTD Gene-Disease Associations 1.0 1.25838 mouth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.0603 KMRC20 CCLE Cell Line Gene CNV Profiles -1.0 -1.34283 RYR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41114 Primary somatosensory area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29916 RAD21_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null sirolimus_mus musculus_gpl7202_gse27784 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HOXA11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74393 Posterior parietal association areas, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10698 IL17RB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62731 DEGS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04973 phosphotransferase activity, alcohol group as acceptor GO Molecular Function Annotations 2015 1.0 null TMC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48618 Brain Lower Grade Glioma_LGG_TCGA-DU-7018-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_16099_KO_Eed_SRP125082 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.78286 TUHR10TKB CCLE Cell Line Gene CNV Profiles 1.0 1.64497 submedius thalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07869 ARMCX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36355 Acrofacial dysostosis Cincinnati type DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.444 Brain Lower Grade Glioma_LGG_TCGA-P5-A5F0-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DIS3L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22303 RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.892766 GSE242199_9_v_0_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null CEBPA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1294 plexiform layer of TuPal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01168 CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.920689 superficial stratum of r7Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10276 HDAC2 ENCODE Transcription Factor Targets 1.0 null gingival fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.452969 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE236437_2_v_3_aldosterone_human RummaGEO Drug Perturbation Signatures -1.0 null intermediate stratum of p2ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.34698 hsa-miR-3126-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.491978 STRADB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19951 LACC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78201 hsa-miR-4254 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 primary motor cortex (area M1, area 4)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.63474 IL17RC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.66805 Bre1-Rad6 ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.758 lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.14612 GSE217115_3_v_5_alectinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE135705_5_v_3_corticosterone_mouse RummaGEO Drug Perturbation Signatures 1.0 null PLAG1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 224.222 Perturb_10891_OE_Trim24_SRP355273 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.82717 Perturb_8601_KO_Pyk2_SRP285527 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.13714 NCIH524 CCLE Cell Line Gene Expression Profiles 1.0 3.00092 Rectum adenocarcinoma_READ_TCGA-AH-6644-01A-21R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null PMC10528072-NIHMS1928302-supplement-5.xlsx-NEUROD1-target_genes-AANAT_NEUROD1 Rummagene Transcription Factor Associations 2026 1.0 null Field CA3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52823 CTCF_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE112765,GSE112767_1_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null cellular protein metabolic process GO Biological Process Annotations 2015 1.0 null GSE157050,GSE157051_2_v_9_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null raphe obscurus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.976399 GSE164463_3_v_1_pax6_mouse RummaGEO Gene Perturbation Signatures -1.0 null orbital frontal cortex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.44595 mRNA_SALL4_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null CEP20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90899 PRRC2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60985 NMB DepMap CRISPR Gene Dependency 1.0 8.59981 Brain Ischemia CTD Gene-Disease Associations 1.0 1.02858 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE212628_3_v_5_mier1_mouse RummaGEO Gene Perturbation Signatures -1.0 null regulation of multicellular organismal process GO Biological Process Annotations 2015 1.0 null H3K27me3_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease of metabolism GWASdb SNP-Disease Associations 1.0 0.079526 GSE181589_2_v_0_spred1_mouse RummaGEO Gene Perturbation Signatures -1.0 null membrane GO Cellular Component Annotations 2015 1.0 null ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08196 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4845-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.234 KMS-12-BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.6456 RFXAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.51162 GSE196699_4_v_3_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null TMEM218 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15671 GSE216273,GSE216292_0_v_1_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null positive regulation of small gtpase mediated signal transduction GO Biological Process Annotations 2015 1.0 null positive regulation of biological process GO Biological Process Annotations 2015 1.0 null Septic Shock_Whole blood_GSE9692 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.56564 type 2 diabetes mellitus GWASdb SNP-Disease Associations 1.0 0.537384 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.977296 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.44904 AP5Z1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34198 GSE190316,GSE190324_1_v_11_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null HCC89 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.834994 PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null r3 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52941 membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE200673,GSE200691_1_v_5_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE210580_3_v_6_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SAMD4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.32864 SNU1079 CCLE Cell Line Gene CNV Profiles 1.0 1.51817 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QH-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GLIS3_KO_GDS3812_500_mouse_Embryonic pancreas at E15.5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null SK-MEL-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40028 SW48 Achilles Cell Line Gene Essentiality Profiles 1.0 1.28553 CAPAN1 CCLE Cell Line Gene Expression Profiles -1.0 -1.49049 Astrocyte_Embryonic prefrontal cortex_Human CellMarker Gene-Cell Type Associations 1.0 null DFCI024 CCLE Cell Line Gene Expression Profiles 1.0 1.71115 H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_16098_KO_Eed_SRP125082 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.22703 GSE101239_3_v_0_valproic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null SUM52PE DepMap CRISPR Gene Dependency 1.0 5.39339 H3K27me3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial part of r3B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30527 hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.051134 EZH2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DDX19A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29907 YAPC CCLE Cell Line Gene Expression Profiles -1.0 -2.33343 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Field CA3, stratum lacunosum-moleculare Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.7726 H3K27me3_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null external granular (germinal) layer of upper rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.940883 TCF7L2-21901280-H4IIE-RAT ChEA Transcription Factor Binding Site Profiles 1.0 null UKE-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.29616 hsa-miR-3714 TargetScan Predicted Conserved microRNA Targets 1.0 0.140752 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68W-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.255241 GSE149035_2_v_0_hepacam_human RummaGEO Gene Perturbation Signatures 1.0 null GSE119498_0_v_10_setd5_mouse RummaGEO Gene Perturbation Signatures 1.0 null ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.91811 cerebralcortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.11749 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050458 STX17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20375 GSE212628_6_v_1_mier1_mouse RummaGEO Gene Perturbation Signatures 1.0 null outer CP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.944141 KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.93551 HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.858947 Nucleus ambiguus, ventral division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4299 Brain Lower Grade Glioma_LGG_TCGA-FG-7634-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP1 JASPAR Predicted Transcription Factor Targets 1.0 null thp-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.270909 PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-1434_proliferation_genes-ZNF766_ZNF766 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE212628_2_v_1_mier1_mouse RummaGEO Gene Perturbation Signatures 1.0 null pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02183 IAH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54112 medial pallium (hippocampal allocortex) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41646 Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hyperglycemia CTD Gene-Disease Associations 1.0 1.15933 OB outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63909 Brain Lower Grade Glioma_LGG_TCGA-QH-A86X-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE183251_1_v_5_cyp2c70_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.869182 HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.96617 Rectum adenocarcinoma_READ_TCGA-AF-2692-11A-01R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.981499 Prolactinoma CTD Gene-Disease Associations 1.0 1.2393 anterior pretectal nucleus, dorsal superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34642 VAMP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1667 POMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43479 acute pancreatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.241196 bounding membrane of organelle GO Cellular Component Annotations 2025 1.0 null t60-adrenal_female_2w MoTrPAC Rat Endurance Exercise Training 1.0 3.31692 regulation of protein kinase activity GO Biological Process Annotations 2015 1.0 null GSE171292_1_v_0_ehhadh_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCI-H2110 COSMIC Cell Line Gene CNV Profiles 1.0 2.09073 Prostatic Diseases CTD Gene-Disease Associations 1.0 1.30451 positive regulation of phosphorus metabolic process GO Biological Process Annotations 2015 1.0 null RREB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.63963 intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 SLC16A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3666 GSE146074_9_v_7_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null KLF15_Deficiency_GDS2687_648_mouse_Liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null TTC549 DepMap CRISPR Gene Dependency 1.0 7.13365 GSE237040_4_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null SUM 159PT Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.847677 superficial stratum of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07253 primary auditory cortex (core)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.951172 GSE225735_1_v_4_aldosterone_human RummaGEO Drug Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-CS-5394-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75604 18614019-TableS4c GeneSigDB Published Gene Signatures 1.0 null EN CCLE Cell Line Gene CNV Profiles -1.0 -1.52969 POU3F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87085 NCIH647 CCLE Cell Line Gene CNV Profiles -1.0 -1.40629 H3K27me3_cardiac mesoderm_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null osteoblasts BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.09162 ESR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.0597 glucose metabolism disease GWASdb SNP-Disease Associations 1.0 0.239251 Brain Lower Grade Glioma_LGG_TCGA-RY-A843-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-Fay_Thermoneutral_LPS-Gene_Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null layer 1 of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28324 H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SNU46 CCLE Cell Line Gene Expression Profiles -1.0 -1.72136 GSE162590_1_v_0_gsx2_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsal entopeduncular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19031 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2R9-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAPK8IP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36378 DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11979 HUG1N Achilles Cell Line Gene Essentiality Profiles -1.0 -1.00546 IPC-298 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE186654_0_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.02 Cervix - Endocervix GTEx Tissue Gene Expression Profiles 2023 1.0 1.80321 hsa-miR-193b TargetScan Predicted Conserved microRNA Targets 1.0 0.265648 Perturb_1311_KO_Cntnap4_SRP386887 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.64538 HEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05503 H3K27me3_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14665 GSE95685_6_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null Muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.506 RUNX1_KO_GDS1511_250_mouse_Embryos at E8.5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE181959_1_v_2_dextran_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE165647_2_v_3_cry2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.46349 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5712-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.08293 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Ovary BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.17559 Brain Lower Grade Glioma_LGG_TCGA-QH-A6CZ-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RNF135 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71105 Mesothelioma_MESO_TCGA-TS-A7OY-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE229671,GSE229673_3_v_1_yrdc_human RummaGEO Gene Perturbation Signatures 1.0 null TYK-NU.CP-R Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.79527 JAK2_activemutant_72_GSE21842 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.68045 RERFLCAD2 DepMap CRISPR Gene Dependency 1.0 5.70491 parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0729 TCOF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05393 layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.03224 HCC1599 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.41814 EGFR_druginhibition_82_GSE27638 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.73004 macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null IZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05775 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Liver Diseases CTD Gene-Disease Associations 1.0 1.21887 r3 part of spinal trigeminal sensory column, oral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2767 primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.896064 HCC1500 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.766801 leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.291722 inner CP in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.920546 GSE214596,GSE214598_1_v_2_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null ZNF281 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 254.89 GINM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.453 pterigoid muscle trigeminal motor cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32904 regulation of intracellular signal transduction GO Biological Process Annotations 2015 1.0 null PFDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91072 parahippocampal gyrus, right, bank of the cos Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00684 FUOV1 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 CTCF_fibroblast of pedal digit skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF677 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.4459 Necrosis CTD Gene-Disease Associations 1.0 1.71524 496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.46724 Cognition Disorders CTD Gene-Disease Associations 1.0 1.2415 GSE153836_11_v_9_fluoxetine_mouse RummaGEO Drug Perturbation Signatures 1.0 null biological_process GO Biological Process Annotations 2015 1.0 null M040416 DepMap CRISPR Gene Dependency 1.0 4.47558 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ATXN7L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.91451 ANKLE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04397 Ventral medial nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37158 dorsolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08184 organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE200673,GSE200691_2_v_0_hmga2_mouse RummaGEO Gene Perturbation Signatures 1.0 null intermediate stratum of r4BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35837 Muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.214 CDC37L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82286 H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JHOM1 CCLE Cell Line Gene Expression Profiles -1.0 -2.13192 ZNF417 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.4525 polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.50552 connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052664 periventricular stratum of r1Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.97366 primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.43562 NCIH1694 CCLE Cell Line Gene Expression Profiles 1.0 2.27237 UM-UC-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null corpus callosum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.71172 Urinary tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 SUDHL10 DepMap CRISPR Gene Dependency 1.0 2.22124 IV Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.944353 SKCO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.33287 salivary gland GTEx Tissue Gene Expression Profiles -1.0 -1.38034 VIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06208 myc_17159920_cancer_cell_lines_lof_human_gpl570_gds2526 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.931532 endocrine system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.04548 NB6 DepMap CRISPR Gene Dependency 1.0 4.74052 PIGW CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82424 mantle zone of CoPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40819 TYMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24462 H2461 COSMIC Cell Line Gene CNV Profiles 1.0 2.09073 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE130690,GSE130692_1_v_0_sirt6_mouse RummaGEO Gene Perturbation Signatures 1.0 null VIIB, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.09428 Brain - Spinal cord (cervical c-1) GTEx Tissue Gene Expression Profiles 2023 1.0 1.54232 parolfactory gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.69942 ZMAT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22907 ventral lateral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34842 GSE201454_1_v_2_ftcd_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE190316,GSE190324_1_v_9_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null Ventral group of the dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.06415 KIF4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24617 Perturb_13974_KO_SYTL3_ERP126655 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 NAA38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80978 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE149124,GSE149128_2_v_1_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-4645-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.48682 496100322_FWM_possible Alzheimer's disease_no TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.14814 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11003700-pbio.3002240.s013.xlsx-siMYCN_RNA_IMR32_48h_q_0_05_1_5-Table_S6_Genes_commonly_and_differentially_regulated_by_MYCN_and_WDR5_in_IMR32_cells_MYCN Rummagene Transcription Factor Associations 2026 1.0 null SHCBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.34656 639-V COSMIC Cell Line Gene Mutation Profiles 1.0 null DHX15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3872 H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SP2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 129.844 SCRT2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.1886 CTCF_fibroblast of mammary gland_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null olfactorybulb BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.12601 V, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.897047 brain HPA Tissue Gene Expression Profiles 1.0 1.08342 NCI-H2795 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20024 RERF-LC-KJ COSMIC Cell Line Gene Mutation Profiles 1.0 null IFT20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3293 MFE319 CCLE Cell Line Gene Expression Profiles 1.0 1.92992 hsa-miR-569 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 hsa-miR-506 TargetScan Predicted Conserved microRNA Targets 1.0 0.136254 GSE202603_0_v_2_bhlhe40_mouse RummaGEO Gene Perturbation Signatures -1.0 null HINFP JASPAR Predicted Transcription Factor Targets 1.0 null outer CP in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.98193 skeletal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.266069 regulation of kinase activity GO Biological Process Annotations 2015 1.0 null eomes_23431145_e14dot5_neocortex_lof_mouse_gpl6246_gse43387 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.129363 C1QTNF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06698 Pax7 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.7786 tooth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.101325 PMC4821877-ncomms10846-s9.xlsx-THP1_Splice_events-Gene_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null positive regulation of phosphate metabolic process GO Biological Process Annotations 2015 1.0 null RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ovary cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05876 GSE125007,GSE125008_3_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Astrocyte_Brain_Human CellMarker Gene-Cell Type Associations 1.0 null hsa-miR-206 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 superficial stratum of ITTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24731 H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Primary somatosensory area, barrel field, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21161 A172 CCLE Cell Line Gene Expression Profiles -1.0 -1.85705 PCNP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17653 hsa-miR-620 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 GSE197117_0_v_1_kdm6b_mouse RummaGEO Gene Perturbation Signatures 1.0 null red nucleus, magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4522 posteroventral (inferior) parietal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.32852 ARL4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33912 HMEL CCLE Cell Line Gene Expression Profiles 1.0 1.45082 DAUDI CCLE Cell Line Gene Expression Profiles -1.0 -1.62268 EZH2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFKB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.7209 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null regulation of protein localization GO Biological Process Annotations 2015 1.0 null stratum lacunosum-moleculare of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.877067 Kidney Chromophobe_KICH_TCGA-KN-8436-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Gordon Holmes syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.391 STAT3-23295773-U87-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null DMAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15273 cellular protein modification process GO Biological Process Annotations 2015 1.0 null hsa-miR-3189-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 Serotonergic synapse COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.948 posteroventral (inferior) parietal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.7093 orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.21999 PRRT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10822 regulation of catalytic activity GO Biological Process Annotations 2015 1.0 null SMAGP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7887 ETFRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8002 CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Dehydration_Hypothalamus_GSE3110 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.65436 RRM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13684 Primary somatosensory area, barrel field Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.67139 Hyperplasia CTD Gene-Disease Associations 1.0 1.56828 M-1 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.06146 H3K27me3_H7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DICER1_Deficiency_GDS3685_518_mouse_Hepatocytes GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ZNF770 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.8359 primary auditory cortex (core)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.888834 positive regulation of protein kinase activity GO Biological Process Annotations 2023 1.0 null acquired metabolic disease GWASdb SNP-Disease Associations 1.0 0.13346 HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02328 PMC4467436-oncotarget-06-6267-s002.xlsx-140527_cd44Cutoff_txt-OLIG2-M_OLIG2 Rummagene Transcription Factor Associations 2026 1.0 null PMC12359252-mmc2.pdf-0-MECOM_MECOM Rummagene Transcription Factor Associations 2026 1.0 null SLC16A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66662 SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.68365 MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01687 mantle zone of r3BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30632 BRCA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44454 PMC6347838-13046_2019_1042_MOESM3_ESM.xls-PRDM16_group_peak_anno-Gene_PRDM16 Rummagene Transcription Factor Associations 2026 1.0 null H3K27me3_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.058281 H3K27me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null ACSM2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81546 GSE232836_2_v_6_morphine_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K27me3_Brain Germinal Matrix Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.123 PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3 Rummagene Transcription Factor Associations 2026 1.0 null AS3MT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02981 central portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13898 TCFL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59156 GSE131887_5_v_2_doxycycline_mouse RummaGEO Drug Perturbation Signatures 1.0 null central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.09124 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4824-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.166095 HS 683 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07282 r8 part of linear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37557 DBH_KO_GDS4324_362_mouse_Embryonic heart E10.5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null KMS-28BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.77951 Perturb_11163_KO_Blnc1_SRP127680 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.50304 RC-K8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.847677 GSS CCLE Cell Line Gene CNV Profiles 1.0 1.57769 regulation of phosphate metabolic process GO Biological Process Annotations 2015 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-06A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEV_60Day_None_GSE53731 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.9486 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 U2OS DepMap CRISPR Gene Dependency 1.0 2.29471 CCNA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17726 apparatus GeneRIF Biological Term Annotations 1.0 null Golgi membrane GO Cellular Component Annotations 2023 1.0 null DNAJA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17312 SOX2-21211035-LN229_GBM-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null KINGS1 DepMap CRISPR Gene Dependency 1.0 2.26157 PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-Fay_Heat_LPStoThermoneutral_LPS-Gene_Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null dorsal part of PcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.78908 positive regulation of protein kinase activity GO Biological Process Annotations 2015 1.0 null HS 69ST Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.56363 Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.004 superficial stratum of DTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13581 PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null NALM1 CCLE Cell Line Gene CNV Profiles -1.0 -1.50511 KNS42 DepMap CRISPR Gene Dependency 1.0 2.01167 Intermediodorsal nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0844 amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.17434 KP3 DepMap CRISPR Gene Dependency 1.0 3.57781 Perturb_14004_OE_Kcnj2_SRP309478 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.8012 GSE101336_1_v_3_decitabine_mouse RummaGEO Drug Perturbation Signatures 1.0 null ADGRG5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7645 EPS15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02653 hypothalamus BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.956077 GSE145323,GSE145324_1_v_2_rfx3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE181517_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_12081_KO_Stat5_SRP060232 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 Paralytic squint DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.066 hsa-miR-1 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.92395 central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE125007,GSE125008_1_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null RELA JASPAR Predicted Transcription Factor Targets 1.0 null KELLY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.967804 motor nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.9276 Primary somatosensory area, trunk, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46054 EZH2 ENCODE Transcription Factor Targets 1.0 null HMC18 CCLE Cell Line Gene Expression Profiles 1.0 1.86728 IPO7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99898 orbital frontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.905395 temporal pole, left, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.14318 hsa-miR-1270 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 CERS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18953 Autosomal recessive limb-girdle muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.223 GSE101239_4_v_6_valproic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null Field CA1, stratum lacunosum-moleculare Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66217 outer plexiform zone in extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.31158 WM793 CCLE Cell Line Gene CNV Profiles 1.0 1.33078 RMC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48836 Ventral posterior complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.83005 HNRNPAB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11431 KMS-12-PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.859618 GSE103309_2_v_0_ube3a_human RummaGEO Gene Perturbation Signatures -1.0 null IZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.61786 Insulin Resistance CTD Gene-Disease Associations 1.0 1.19672 SH3BP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07211 anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.99265 Non-alcoholic Fatty Liver Disease CTD Gene-Disease Associations 1.0 1.20558 NOP53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5078 RERFLCAD2 CCLE Cell Line Gene CNV Profiles 1.0 1.3356 H3K27me3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null regulation of protein kinase activity GO Biological Process Annotations 2023 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.593649 positive regulation of intracellular signal transduction GO Biological Process Annotations 2015 1.0 null NCIH660 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.83839 mantle zone of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.77951 biliary tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.059771 Rectum adenocarcinoma_READ_TCGA-F5-6810-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WDR20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11898 CHCHD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02243 inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.83122 RAB6D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52587 FKBP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65829 NCIH650 DepMap CRISPR Gene Dependency 1.0 2.00813 HCC1359 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.858947 temporotympanic muscle trigeminal motor cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.1223 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81E-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r7 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09522 PFKM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5679 parasitic infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.057206 MET_knockout_258_GSE25583 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 0.722512 X Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.0557 inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28221 PWWP2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.38156 H3K27me3_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null organic substance metabolic process GO Biological Process Annotations 2015 1.0 null primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.16792 sarcolemma COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.156688 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IR-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adenoma, Liver Cell CTD Gene-Disease Associations 1.0 1.38355 496100500_PCx_probable Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.33946 C2CD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42816 EZH2_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null frontalcortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.839549 mantle zone of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51256 PATZ1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 343.836 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1ML-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null outer CP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08788 bounding membrane of organelle GO Cellular Component Annotations 2015 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mononuclear phagocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.154613 Eye_CT1_glial cell HuBMAP ASCT+B Augmented with RNA-seq Coexpression 1.0 null LN319 Achilles Cell Line Gene Essentiality Profiles -1.0 -2.30612 BRI3BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59069 GSE210580_3_v_11_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040075 TFAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42141 Main olfactory bulb, inner plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14387 POU3F4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.21 ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.265 regulation of phosphorylation GO Biological Process Annotations 2015 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null III, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.32818 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5000-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DNPEP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16697 SUM 149PT Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.977938 WM88 CCLE Cell Line Gene CNV Profiles -1.0 -2.59447 H4 CCLE Cell Line Gene CNV Profiles 1.0 1.89085 NME6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90787 layer III of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.70653 IFIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15877 gata4_21746915_heart_lof_mouse_gpl6246_gds3931 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.696081 Lateral posterior nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14652 CAV3_KO_GDS3533_17_mouse_mammary glands GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null RPL7A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00681 LCLC-97TM1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE210580_4_v_1_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null DNAJC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51474 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.33966 YAP1 ChEA Transcription Factor Targets 1.0 null NPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21877 putamen, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.93897 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3673 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 superficial stratum of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66249 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5682-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE205163,GSE205164_2_v_0_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GLIS2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.3028 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27778 TPRG1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21938 NCI-H2052 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19084 GSE210580_4_v_12_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null POU2F2 JASPAR Predicted Transcription Factor Targets 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H0-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF221 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26121 HEC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null RT11284 CCLE Cell Line Gene Expression Profiles -1.0 -3.27667 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.87999 Brain Lower Grade Glioma_LGG_TCGA-RY-A83Y-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of p3ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38302 paqr10 GeneRIF Biological Term Annotations 1.0 null abnormality of metabolism/homeostasis GWASdb SNP-Phenotype Associations 1.0 0.043849 SP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 184.681 intermediate stratum of VTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.54267 Primary somatosensory area, barrel field, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.72777 principal pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33335 ZBTB34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29259 Lung adenocarcinoma_LUAD_TCGA-53-7624-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_13302_KO_Tet2_SRP338315 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.42021 hsa-miR-3689a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 Postlarva TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.565 BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE105169,GSE105175_0_v_1_dhx36_human RummaGEO Gene Perturbation Signatures 1.0 null KMT5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.131 Genetic Predisposition to Disease HuGE Navigator Gene-Phenotype Associations 1.0 null hsa-miR-4652-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 RPL13A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12071 hsa-miR-4673 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 ZNF140 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.3995 GSE88819_3_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null parietal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.23377 MDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.06107 GSE242199_9_v_7_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null Principal sensory nucleus of the trigeminal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6924 hsa-miR-374c TargetScan Predicted Conserved microRNA Targets 1.0 0.131849 hematopoietic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.071809 Brain Lower Grade Glioma_LGG_TCGA-HT-7480-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of r4BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18755 monocytic leukemia cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.642048 ANLN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58428 TE-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.09073 Mat-Ly-Lu cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.555 GPN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11185 inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.53691 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.497 H3K27me3_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114690_1_v_0_tnfsf14_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE214514_1_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-91-6830-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_11197_KD_Pten_SRP311091 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -11.9369 ZNF777 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21776 Perturb_13976_KO_H3f3a/H3f3b_ERP109384 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 12.936 cho cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.212761 H3K27me3_erythroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.828292 GSE202603_3_v_2_bhlhe40_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29309 striatum_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.881372 B4GAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.67524 transferase activity GO Molecular Function Annotations 2015 1.0 null AdipoR/Haemolysin-III-related InterPro Predicted Protein Domain Annotations 1.0 null hsa-miR-665 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.22301 Lung squamous cell carcinoma_LUSC_TCGA-68-A59I-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MHHES1 CCLE Cell Line Gene Expression Profiles -1.0 -1.67248 DACT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94563 Brain Lower Grade Glioma_LGG_TCGA-F6-A8O3-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SBF transcription complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.591 ECC4 DepMap CRISPR Gene Dependency 1.0 2.42291 caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.45306 inflammatory bowel disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.304503 GSE216273,GSE216292_14_v_1_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null FKBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04628 GSE229671,GSE229673_0_v_1_yrdc_human RummaGEO Gene Perturbation Signatures 1.0 null MEWO COSMIC Cell Line Gene Mutation Profiles 1.0 null cellular metabolic process GO Biological Process Annotations 2015 1.0 null r2 part of ventral lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55465 POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GMS-10 COSMIC Cell Line Gene Mutation Profiles 1.0 null reticulotegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.897571 Primary hematopoietic stem cells G-CSF-mobilized Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.952555 EZH2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE81193_3_v_5_irf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null NPPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30604 LAMA84 Achilles Cell Line Gene Essentiality Profiles 1.0 1.13418 r1 part of vestibular nucleus Y Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.9756 HEC1B CCLE Cell Line Gene Expression Profiles -1.0 -2.24774 dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.22838 PCF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37442 hsa-miR-4496 TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 SKNSH DepMap CRISPR Gene Dependency 1.0 2.56282 H3K27me3_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCFL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 75.7118 H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CAV3_KO_GDS3533_357_mouse_mammalian glands GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null primary motor cortex (area M1, area 4)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.852766 LU-99A COSMIC Cell Line Gene CNV Profiles 1.0 2.09073 Metaphase plate COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.685 hsa-miR-409-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Muscle - Skeletal GTEx Tissue Gene Expression Profiles 2023 1.0 3.20418 positive regulation of metabolic process GO Biological Process Annotations 2015 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A5R3-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COX7A2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73731 BACH1 ENCODE Transcription Factor Targets 1.0 null SUZ12 ENCODE Transcription Factor Targets 1.0 null H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC2185 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.658776 peripeduncular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32799 PAX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.35953 H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null regulation of response to stimulus GO Biological Process Annotations 2015 1.0 null TCP1_02_194 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.45943 BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.64498 viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.222699 JHH1 DepMap CRISPR Gene Dependency 1.0 3.93972 CD34+ BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.9427 H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Primary somatosensory area, barrel field, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.24764 temporal pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.843926 EGFR_druginhibition_83_GSE27640 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.48744 Nauplius TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.642 collectively GeneRIF Biological Term Annotations 1.0 null hsa-miR-200b TargetScan Predicted Conserved microRNA Targets 1.0 0.828473 orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.912368 medial parabrachial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.826042 AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null positive regulation of cellular process GO Biological Process Annotations 2015 1.0 null posterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00143 superior colliculus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05711 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 H4 DepMap CRISPR Gene Dependency 1.0 7.62542 body of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.54487 anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23057 Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CTCF_foreskin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_CH12.LX_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ENTPD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74023 PMC6870463-Table_7.xlsx-Family_H_No_LPS-Untreated_BMDMs_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null CHORDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86142 present GeneRIF Biological Term Annotations 1.0 null SLU7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.28438 body wall TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.144002 CTCF_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary somatosensory area, upper limb, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.72308 THRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.8571 KCTD21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57171 Anterior pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00929 PMC7940623-41467_2021_21725_MOESM11_ESM.xlsx-Extended_data_table_9_regulons-EGR2_extended_EGR2 Rummagene Transcription Factor Associations 2026 1.0 null WDR89 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19429 CTCF_fibroblast of foreskin _hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null SCC4 CCLE Cell Line Gene Expression Profiles -1.0 -1.54805 primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26152 primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.843682 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE180377_2_v_1_lipa_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_15083_KD_Nsd1_SRP354984 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -11.4386 PPARA::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.8492 C2CD4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27302 GSE218580_1_v_3_fentanyl_mouse RummaGEO Drug Perturbation Signatures -1.0 null Nasopharynx TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 NF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70707 CTCF_GM13977_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DV-90 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.953 KDM4A ENCODE Transcription Factor Targets 1.0 null MPDU1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26784 mRNA_EP400_22196727 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null GAK COSMIC Cell Line Gene Mutation Profiles 1.0 null Primary somatosensory area, nose Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13094 superficial stratum of DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.15351 mRNA_EOMES_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null GSE110303,GSE110304_1_v_0_estradiol_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE143316_0_v_6_somatostatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE229978_4_v_1_morphine_mouse RummaGEO Drug Perturbation Signatures -1.0 null RS411 CCLE Cell Line Gene CNV Profiles -1.0 -1.70034 HAUS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.66008 CLEC14A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28436 Linear nucleus of the medulla Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27767 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4691-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Celiac Disease HuGE Navigator Gene-Phenotype Associations 1.0 null TBCA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30548 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HT-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.21187 Fetal Brain Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -2.04368 blood TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.070153 PREB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51965 GSE157555,GSE157556_5_v_1_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null regulation of protein localization GO Biological Process Annotations 2025 1.0 null Infertility, Male CTD Gene-Disease Associations 1.0 1.43212 ZBTB7B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.2545 signalling GeneRIF Biological Term Annotations 1.0 null developmental disorder of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.071942 GSE207978_1_v_0_rai1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF143 ENCODE Transcription Factor Targets 1.0 null ZSCAN12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52888 autistic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.317545 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.65725 PRRC2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43409 hsa-miR-331-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GSE200673,GSE200691_1_v_3_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.65408 epidermis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.844331 bounding membrane of organelle GO Cellular Component Annotations 2023 1.0 null mantle zone of CA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26081 superficial stratum of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03329 primary auditory cortex (core)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.52916 Dentate gyrus, granule cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.34371 positive regulation of small GTPase mediated signal transduction GO Biological Process Annotations 2023 1.0 null INSM1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.4167 UPCISCC152 DepMap CRISPR Gene Dependency 1.0 3.00727 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW 1116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24217 Perturb_14516_KO_Kras_SRP311976 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.42513 hsa-miR-661 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ATF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.0109 tail of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.43689 PK-45P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.912864 Dentate gyrus, polymorph layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.38394 IZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00349 regulatory GeneRIF Biological Term Annotations 1.0 null EZH2_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUM44PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.922036 RGMB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37002 H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null plasma membrane LOCATE Predicted Protein Localization Annotations 1.0 null P4HA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81449 PGLYRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26584 mitochondrion LOCATE Predicted Protein Localization Annotations 1.0 null GSE210580_5_v_7_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null MYC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97165 TRIM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05181 CP in rostral hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05751 EB1 CCLE Cell Line Gene Expression Profiles -1.0 -2.01272 mRNA_ZFAND3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Ventral anterior-lateral complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57887 macromolecule modification GO Biological Process Annotations 2015 1.0 null Perturb_8602_KO_Mir132_SRP064164 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.39411 ESCO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5642 Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZP-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null lower limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.4792 Intracellular anatomical structure COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 CTCF_BE2C_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null vertebrate muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056519 Uterine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.893 ROCK_INHIBITION_GDS3944_463_mouse_Forebrain astrocytes - 12 Hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Perturb_10866_KO_Hsf1_SRP116890 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.89577 BLMH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68621 hsa-miR-655 TargetScan Predicted Conserved microRNA Targets 1.0 0.123298 GSE210580_4_v_6_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF675 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.60519 hsa-miR-323-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GSE225735_0_v_4_aldosterone_human RummaGEO Drug Perturbation Signatures 1.0 null CELSR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90182 Adrenocortical carcinoma_ACC_TCGA-OR-A5LB-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null C1orf56 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51392 JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null outer CP in midlateral extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.834851 TIMM23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35715 r3 part of anteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66402 Amylin receptor complex 2 COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.528 blast cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.113968 GSE165704_0_v_1_rif1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PPP1R14A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40676 CEBPD JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.7959 H2BC18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40058 intermediate mantle of isBM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3165 Miyoshi muscular dystrophy 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.909 SEC24B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76127 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.863955 SLK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72397 Brain Lower Grade Glioma_LGG_TCGA-DU-7294-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKGT4 DepMap CRISPR Gene Dependency 1.0 7.18346 granule cell layer of the DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.44506 CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null regulation of ras protein signal transduction GO Biological Process Annotations 2015 1.0 null KIRREL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15905 regulation of biological process GO Biological Process Annotations 2015 1.0 null Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.291 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 functions GeneRIF Biological Term Annotations 1.0 null H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_10857_KO_Shp_SRP220815 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.86298 EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mRNA_GADD45A_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE149769_1_v_0_nlrp12_mouse RummaGEO Gene Perturbation Signatures -1.0 null monocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.156923 HCC70 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.03452 ZBTB14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.821 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05729 paradigm GeneRIF Biological Term Annotations 1.0 null NMCG1 DepMap CRISPR Gene Dependency 1.0 3.23067 diabetes mellitus GWASdb SNP-Disease Associations 1.0 0.281812 chr7_4964600_T_C_b38 GTEx eQTL 2025 1.0 2.28658 H3K27me3_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-BrtoFay_Thermoneutral_LPS-Gene_Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null HDLM2 CCLE Cell Line Gene CNV Profiles -1.0 -1.52046 myeloid progenitor cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.123557 positive regulation of cell differentiation GO Biological Process Annotations 2023 1.0 null GSE180321_0_v_1_imperatorin_human RummaGEO Drug Perturbation Signatures -1.0 null ZSWIM8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46811 H3K27ac_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_10709_KO_Ezh1/Ezh2_SRP133172 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.2635 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OPM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5265 NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32413 Prostomium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.836 DDX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09703 superficial stratum of r2Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47762 ZFTA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33233 medial portion of STH Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.882524 Encephalomyelitis, Autoimmune, Experimental CTD Gene-Disease Associations 1.0 1.07057 adult stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.094385 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GNE myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.133 Main olfactory bulb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59587 body of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.63472 CTDNEP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35549 inner CP in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.8807 cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 BICR31 CCLE Cell Line Gene CNV Profiles 1.0 2.77169 H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null phosphorus metabolic process GO Biological Process Annotations 2015 1.0 null mRNA_SMAD7_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE200687,GSE200688_1_v_0_sox15_mouse RummaGEO Gene Perturbation Signatures 1.0 null bladder GTEx Tissue Gene Expression Profiles -1.0 -1.38034 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null ERF::NHLH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.8958 Mouth TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 LKAAEAR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82376 CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.97747 H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HSD17B4_KO_GDS3468_503_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null 496100406_HIP_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.62988 cytoplasmic part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 TOR2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82032 abnormality of carbohydrate metabolism/homeostasis GWASdb SNP-Phenotype Associations 1.0 0.167666 temporal muscle trigeminal motor cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.85062 primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05755 intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.8492 positive regulation of cellular protein metabolic process GO Biological Process Annotations 2015 1.0 null 496100444_HIP_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.04387 regulation of macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null Nucleus ambiguus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31054 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary auditory cortex (core)_25 pcw_F_12948 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.83122 NCIH596 CCLE Cell Line Gene CNV Profiles 1.0 1.62775 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.46 SMIM24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65996 PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-combined_portrait-EGR1_EGR1 Rummagene Transcription Factor Associations 2026 1.0 null COPG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01667 GSE149124,GSE149128_3_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE151160_0_v_1_cd36_mouse RummaGEO Gene Perturbation Signatures 1.0 null KP2 CCLE Cell Line Gene Expression Profiles -1.0 -1.49446 MAVS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39164 primary metabolic process GO Biological Process Annotations 2015 1.0 null GSE79291_1_v_2_streptozotocin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE110673,GSE110674_4_v_5_glucagon_mouse RummaGEO Drug Perturbation Signatures -1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null organelle part GO Cellular Component Annotations 2015 1.0 null ZFP42 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.9989 ras GeneRIF Biological Term Annotations 1.0 null SP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 200.66 H3K27me3_megakaryocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of CoPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72358 grhl3_16949565_skin_lof_mouse_gpl1261_gds2629 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.556779 GSE175883_0_v_1_dis3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-V9-A7HT-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mesothelioma_MESO_TCGA-SC-A6LM-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KLF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 152.37 PMC3470785-NIHMS377161-supplement-12.pdf-639-ZNF280B_ZNF280B Rummagene Transcription Factor Associations 2026 1.0 null oculomotor nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.834568 DBTRG05MG DepMap CRISPR Gene Dependency 1.0 2.93943 PMC4060771-170289.f1.pdf-200-MLL_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null GSE217541,GSE217543_0_v_2_tet1_human RummaGEO Gene Perturbation Signatures -1.0 null Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.4871 GSE61117_0_v_1_trim24_mouse RummaGEO Gene Perturbation Signatures 1.0 null r5 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19031 Dentate gyrus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.0491 Supplemental somatosensory area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01012 OSC-20 COSMIC Cell Line Gene CNV Profiles 1.0 2.09073 flexor TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.29996 regulation of cellular protein metabolic process GO Biological Process Annotations 2015 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LO-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null positive regulation of signaling GO Biological Process Annotations 2015 1.0 null ALG9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64317 parvocellular part of the r9LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.18068 GSE178227_1_v_0_tet1_mouse RummaGEO Gene Perturbation Signatures -1.0 null glia TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.4185 GSE210580_3_v_2_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.472 H3K4me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE160373_8_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null MESSA CCLE Cell Line Gene CNV Profiles -1.0 -1.6754 DOHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.963872 HPS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43931 CTCF_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05468 KLF10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 189.411 Signal recognition particle receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.815 ventromedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.17122 molecular_function GO Molecular Function Annotations 2015 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5KV-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null positive regulation of small GTPase mediated signal transduction GO Biological Process Annotations 2025 1.0 null STAT3 ChEA Transcription Factor Targets 1.0 null ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FARSA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37292 hnf4a_16714383_e18dot5_liver_lof_mouse_gpl1261_gds1916 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.015554 WDR81 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3039 Liver GTEx Tissue Gene Expression Profiles 2023 1.0 2.47694 Urogenital Abnormalities CTD Gene-Disease Associations 1.0 1.01025 organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050918 Perturb_10903_KO_Ppp1r3c_SRP019798 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.73055 CPNE7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28415 UCKL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16391 HDAC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86667 hippocampus (hippocampal formation)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0124 anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.944492 KLF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 117.934 TOV-112D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.858947 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null ventral posteromedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.72308 ENTPD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.952 PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.838637 GSE184210_0_v_2_glucagon_mouse RummaGEO Drug Perturbation Signatures -1.0 null KLF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.02344 GSE157555,GSE157556_0_v_1_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null cellular process GO Biological Process Annotations 2015 1.0 null SKOV3 CCLE Cell Line Gene CNV Profiles -1.0 -1.37177 superficial stratum of PCPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.15765 Perturb_2890_KO_Mecp2_SRP154883 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.69988 AOB, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07392 H3K4me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null parietal cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03724 Prostate adenocarcinoma_PRAD_TCGA-KK-A8ID-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nucleus of the lateral lemniscus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2383 pervasive developmental disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.242245 molecular layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09454 ZNF701 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 81.1504 limb-girdle muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.556732 DNASE1L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56096 C3orf38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80225 membrane LOCATE Predicted Protein Localization Annotations 1.0 null positive regulation of protein phosphorylation GO Biological Process Annotations 2025 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.908048 hsa-miR-1 TargetScan Predicted Conserved microRNA Targets 1.0 0.568687 RCN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20589 supramammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33721 posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.833567 STAT3 MotifMap Predicted Transcription Factor Targets 1.0 null Hepatomegaly CTD Gene-Disease Associations 1.0 1.14166 Asthma_Epithelial Cell_GSE4302 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.57643 mucus layer COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.681155 HT-115 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K27me3_erythroblast_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null peripheral portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.42007 AP5M1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82543 H3K27me3_H7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ISOC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53437 olivary pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.78765 YAP1-20516196-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null ZNF816 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 77.6562 Primary somatosensory area, trunk, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07201 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null positive regulation of neuron differentiation GO Biological Process Annotations 2015 1.0 null Golgi membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042165 Autosomal recessive limb-girdle muscular dystrophy type 2B DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.513 Liver Cirrhosis, Experimental CTD Gene-Disease Associations 1.0 1.12323 MCF10F Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.18575 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null COLO704 CCLE Cell Line Gene Expression Profiles 1.0 2.34603 Pharynx TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 head of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.83915 periodontium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.162893 positive regulation of signal transduction GO Biological Process Annotations 2015 1.0 null RAB12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38822 pretectal nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.952251 GSE101239_4_v_1_valproic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaDadj_vs_NC-Gene_ERG Rummagene Transcription Factor Associations 2026 1.0 null KDM4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12825 TRAPPC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20013 positive regulation of phosphorylation GO Biological Process Annotations 2015 1.0 null hsa-miR-200c TargetScan Predicted Conserved microRNA Targets 1.0 0.766596 TMA16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31861 Perturb_15079_KD_Ash1l_SRP354984 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.13701 GSE119701_0_v_1_phf7_mouse RummaGEO Gene Perturbation Signatures -1.0 null lateral hypothalamic area, anterior part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17626 SNU886 CCLE Cell Line Gene Expression Profiles -1.0 -2.53682 RPN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28041 regulation of signal transduction GO Biological Process Annotations 2015 1.0 null 496100330_PCx_possible Alzheimer's disease_no TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.46935 orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.856589 Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.14 Posterior pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25856 Atherosclerosis CTD Gene-Disease Associations 1.0 1.46515 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20H-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8507-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.48201 hsa-miR-4421 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Lateral shield COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.504 EMC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90726 Senile cataract DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.104 Inflammation CTD Gene-Disease Associations 1.0 1.31716 PURB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.30323 Prostatitis CTD Gene-Disease Associations 1.0 1.04831 positive regulation of cell development GO Biological Process Annotations 2015 1.0 null V Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.15647 GSE119498_2_v_4_setd5_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE196699_4_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null HOP-92 COSMIC Cell Line Gene Mutation Profiles 1.0 null supraoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14239 GSE158834_0_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null ERG28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69072 SC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.847677 ATP6V1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01301 GSE249714_0_v_1_anxa1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SK-MEL-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.82857 Foxj3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.2414 SCRT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.1367 GSE159446,GSE159449_1_v_0_tunicamycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null positive regulation of Ras protein signal transduction GO Biological Process Annotations 2025 1.0 null H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A2IZ-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE205163,GSE205164_2_v_4_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-509-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.568687 primary auditory cortex (core)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.49189 IRAK2_knockout_39_GSE10765 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.85451 positive regulation of kinase activity GO Biological Process Annotations 2015 1.0 null regulation of cell communication GO Biological Process Annotations 2015 1.0 null cochlear nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.933702 mantle zone of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03568 GSE119498_0_v_5_setd5_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE105781_1_v_0_grhl2_mouse RummaGEO Gene Perturbation Signatures 1.0 null MTA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24099 inferior olive, principal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14919 PMC11653668-ADVS-11-2400133-s005.pdf-18-KDM2A_KDM2A Rummagene Transcription Factor Associations 2026 1.0 null OB inner plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1654 muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.283191 cytoplasmic part GO Cellular Component Annotations 2015 1.0 null hsa-miR-613 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 GSE158834_0_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null POU3F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1213 oval paracentral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52941 CTCF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PGAP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.34542 stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.11493 EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24337 t60-adrenal_female_8w MoTrPAC Rat Endurance Exercise Training 1.0 1.95452 RAB3A_Mutation - D77G point mutation_GDS2482_704_mouse_Hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null primary auditory cortex (core)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0025 SHISA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41088 SU-DHL-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07662 positive regulation of kinase activity GO Biological Process Annotations 2025 1.0 null Tegmental reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55327 LPIN1_OE_GDS2291_587_mouse_Liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null RXRA::VDR JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.0 NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.977938 primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.30984 NTERA2CLD1 DepMap CRISPR Gene Dependency 1.0 2.92987 HCC1599 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05503 Main olfactory bulb, outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40718 Cysticercus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.538 IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.01603 temporal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00786 muscle tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.254536 nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K27me3_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFKB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.9299 H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PRDM9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 325.15 RFC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71087 BIM-BCL-2 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.775 496100478_HIP_dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.53136 Dentate gyrus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.1721 ventral tegmental area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.912389 LRP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44993 Orbital area, ventrolateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20167 positive regulation of transferase activity GO Biological Process Annotations 2015 1.0 null regulation of cellular localization GO Biological Process Annotations 2023 1.0 null ACTR6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27473 primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.831919 SP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.53989 TEAD1 JASPAR Predicted Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZD-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMPCB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49946 uncovers GeneRIF Biological Term Annotations 1.0 null Perturb_10920_KO_fatp2_SRP229353 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.73683 BT474 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.19744 PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST18-Supplementary_Data_18_Gene_burden_for_deletions_by_subtype_ST18 Rummagene Transcription Factor Associations 2026 1.0 null Field CA3, stratum radiatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62796 GSE153836_11_v_2_fluoxetine_mouse RummaGEO Drug Perturbation Signatures 1.0 null HES1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.9301 occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.20304 Perturb_2892_KO_Crls1_SRP132399 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 HECA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26637 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE131887_1_v_0_doxycycline_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE216273,GSE216292_14_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null RPL17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46137 primary motor cortex (area M1, area 4)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.906062 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.237042 RGPD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0114 SH2D2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08815 Ventral posterolateral nucleus of the thalamus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28369 GSE125007,GSE125008_4_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null VWA5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81596 SW579 CCLE Cell Line Gene CNV Profiles 1.0 2.7352 hsa-miR-593 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CNOT8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11429 Rectum adenocarcinoma_READ_TCGA-AF-2689-11A-01R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ABCA1_OE_GDS2303_189_mouse_LDL receptor-deficient livers GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GPX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5823 substantia innominata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.901182 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNRNPM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34546 SRY-25088423-EMBRYONIC GONADS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null cortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.842053 Perturb_10872_KO_fatp2_SRP229353 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.95865 MKNK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58876 Brain Lower Grade Glioma_LGG_TCGA-HT-7468-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of PcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34495 glis3_19805515_embryonic_pancreas_lof_mouse_gpl1261_gds3812 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.801706 Nucleus y Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19212 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null positive regulation of protein kinase activity GO Biological Process Annotations 2025 1.0 null r1 part of vestibulocerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.64627 NR2C2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.8712 r3 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03884 OSC-19 COSMIC Cell Line Gene CNV Profiles 1.0 2.09073 GSE189683_1_v_2_rif1_mouse RummaGEO Gene Perturbation Signatures -1.0 null EOLA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00823 OBSCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2021 Perturb_15082_KD_Ehmt1_SRP354984 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -11.7304 hsa-miR-3160-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H3-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE237040_4_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null POU2F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.7081 NGRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77241 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.24488 MMAB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59492 outer SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.50126 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null Liver Neoplasms CTD Gene-Disease Associations 1.0 1.67333 hsa-miR-4731-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.319726 Depressive Disorder CTD Gene-Disease Associations 1.0 1.19179 hsa-miR-4279 TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 GSE178227_1_v_2_tet1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE184210_0_v_1_glucagon_mouse RummaGEO Drug Perturbation Signatures -1.0 null golgi GeneRIF Biological Term Annotations 1.0 null Eye cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 L363 Achilles Cell Line Gene Essentiality Profiles 1.0 1.20962 reticular formation of CoPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08452 Miyoshi muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.185 H4C8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7358 Primary somatosensory area, barrel field, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00069 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.328 olfactory tubercle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.915591 implement GeneRIF Biological Term Annotations 1.0 null H3K27me3_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.01468 regulation of neurogenesis GO Biological Process Annotations 2015 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A465-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null atrophic muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.491978 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null OCIAML2 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.26576 CTCF_cardiac fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77059 JHESOAD1 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.14339 CTCF_fibroblast of foreskin _hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06947 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.49129 Perturb_1065_Mut_Esr1_SRP087718 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.9993 Whole Blood GTEx Tissue Gene Expression Profiles 2023 1.0 2.62506 PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD Rummagene Transcription Factor Associations 2026 1.0 null GSE154767_1_v_5_adam10_mouse RummaGEO Gene Perturbation Signatures 1.0 null TBPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88747 GSE214248_0_v_1_cxcl8_human RummaGEO Gene Perturbation Signatures 1.0 null Nr5a1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.3719 KASUMI2 CCLE Cell Line Gene CNV Profiles -1.0 -1.52526 GSE210580_0_v_7_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null RBM15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39702 GSE213632_1_v_5_acod1_mouse RummaGEO Gene Perturbation Signatures -1.0 null APOL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25033 oculomotor nuclear complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2035 anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.38345 primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.15539 ZNF281 ChEA Transcription Factor Targets 1.0 null CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF676 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38427 mRNA_TCF3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null GSE210580_4_v_7_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE232564,GSE232566_0_v_2_nsd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-892b TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 KMS26 CCLE Cell Line Gene Expression Profiles 1.0 1.36425 p2 part of the zona limitans core population Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23449 CTCF_fibroblast of villous mesenchyme_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Geniculate group, dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07533 spatial GeneRIF Biological Term Annotations 1.0 null biological regulation GO Biological Process Annotations 2015 1.0 null positive regulation of Ras protein signal transduction GO Biological Process Annotations 2023 1.0 null TUBA1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92201 EEF1A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31416 Small Intestine - Terminal Ileum GTEx Tissue Gene Expression Profiles 2023 1.0 2.16444 H3K4me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE131887_5_v_3_doxycycline_mouse RummaGEO Drug Perturbation Signatures 1.0 null WM115 CCLE Cell Line Gene CNV Profiles 1.0 1.38843 inferior olive, medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.979489 Obstructive sleep apnea_Hepatic Tissue_GSE1873 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.96343 amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.59983 GSE110673,GSE110674_4_v_3_glucagon_mouse RummaGEO Drug Perturbation Signatures -1.0 null Retinoblastoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 regulation of protein localization GO Biological Process Annotations 2023 1.0 null substantia nigra, reticular part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.48082 LYRM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.54222 CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.957701 H3K27me3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU423 DepMap CRISPR Gene Dependency 1.0 2.01239 dorsomedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.09662 dorsal subnucleus of MG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29728 Membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.15192 SUZ12-20075857-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null SJSA-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.811 positive regulation of macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null Field CA2, stratum lacunosum-moleculare Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3771 inner CP in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.96411 parvocellular part of r8LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04421 ZNF253 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90023 hsa-miR-4257 TargetScan Predicted Conserved microRNA Targets 1.0 0.828473 ZSCAN30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46038 YY1 JASPAR Predicted Transcription Factor Targets 1.0 null POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null STEAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68753 Mecom JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.8889 olfactory bulb, principal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51152 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.599273 tobacco use disorder GAD Gene-Disease Associations 1.0 null m4 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.622 Rectum adenocarcinoma_READ_TCGA-AG-3592-01A-02R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H441 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11919 H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30643 PNMA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69298 RBM12B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61759 inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.932396 Minor Salivary Gland GTEx Tissue Gene Expression Profiles 2023 1.0 1.16484 Perturb_10868_KO_Ghr_SRP269490 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.93773 Perturb_17296_KO_Sox8/Sox9_ERP014609 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7S9-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hippocampal region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65767 OB olfactory fiber layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.83572 Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.09 CRAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09167 Vdr JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.1589 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 TCF7L2 ChEA Transcription Factor Targets 1.0 null NDUFC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.96188 corl105 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.042 diabetes mellitus GWASdb SNP-Phenotype Associations 1.0 0.259025 Glioma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 hsa-miR-4751 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 regulation of metabolic process GO Biological Process Annotations 2015 1.0 null ovary TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055112 SKMEL30 DepMap CRISPR Gene Dependency 1.0 4.97222 CYB5R1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10382 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 abnormality of the endocrine system GWASdb SNP-Phenotype Associations 1.0 0.069787 Red nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18664 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.1865 Perturb_11094_KO_Regnase1_DRP004811 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.3262 PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCallEPC1-PHF1_H3K27me3_k562-SYMBOL_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.858403 SRY ChEA Transcription Factor Targets 1.0 null H3K27me3_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null NOB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.08746 superficial stratum of r2BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55866 CAKI1 DepMap CRISPR Gene Dependency 1.0 2.93319 Gastrointestinal tract TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 subethmoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37044 ARL16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74118 OCI-LY-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.41798 Perturb_17325_KO_Dis3l2_SRP322105 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.53429 STX1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11111 POLR2A ENCODE Transcription Factor Targets 1.0 null T84 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5010-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SK-OV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.07835 ChIP_K27me3_17603471_mouseMEF ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null DCAF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46887 Urinary bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 CHRNA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8007 NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.08689 retinoblastoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE68156_0_v_5_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04396 RAD21_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null regulation of protein kinase activity GO Biological Process Annotations 2025 1.0 null Field CA1, stratum radiatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23426 r7 portion of ambiguous motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10239 GSE193588_3_v_2_pax3_mouse RummaGEO Gene Perturbation Signatures -1.0 null autism spectrum disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.291898 SMC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61464 Brain Lower Grade Glioma_LGG_TCGA-TM-A7C5-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMEM101 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34565 H3K4me1_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null blood cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.243918 Stat2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 61.321 POU2F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.8275 hsa-miR-4675 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null distal muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.846669 Retrosplenial area, lateral agranular part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06524 fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062226 RGS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03144 H3K27me3_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.90164 SNU475 CCLE Cell Line Gene Expression Profiles -1.0 -2.6967 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.40381 Lung adenocarcinoma_LUAD_TCGA-86-8358-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ventral posteromedial nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71219 Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.10875 SUM102PT DepMap CRISPR Gene Dependency 1.0 2.87106 paracentral lobule, posterior part, left, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.49154 intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 posterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.858742 posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.64181 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null disease GWASdb SNP-Disease Associations 1.0 0.023758 C11orf96 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22447 VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.397 Ventral posterolateral nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.46295 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NH12 DepMap CRISPR Gene Dependency 1.0 2.03827 GSE160373_5_v_4_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF275 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89632 Pq TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.046 positive regulation of protein phosphorylation GO Biological Process Annotations 2015 1.0 null DOV13 DepMap CRISPR Gene Dependency 1.0 2.07417 intracellular organelle part GO Cellular Component Annotations 2015 1.0 null superficial stratum of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17063 PMC4269325-NIHMS634665-supplement-supp_table4.xls-H3K27me3_TRIM37_KD-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71V-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_14781_KO_Kansl2_SRP225948 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.88243 PANC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02131 496100628_FWM_dementia_TBI_77_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.00188 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.922148 hsa-miR-670 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 PMC6078853-molce-41-7-695-suppl2.xlsx-Sheet1-Table_S1_Genes_exhibiting_two-fold_changes_in_expression_between_WT_and_CTCF_KO_otocyst_with_FDR_less_than_0_05_CTCF Rummagene Transcription Factor Associations 2026 1.0 null GSE119498_0_v_7_setd5_mouse RummaGEO Gene Perturbation Signatures 1.0 null r4 part of reticulotegmental nucleus, shell portion Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31959 abnormal glucose homeostasis GWASdb SNP-Phenotype Associations 1.0 0.184395 OCIAML5 Achilles Cell Line Gene Essentiality Profiles 1.0 1.18069 SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dentate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19695 paqr11 GeneRIF Biological Term Annotations 1.0 null Myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.263 muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059074 Orbital area, lateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10602 bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.27592 Brain Lower Grade Glioma_LGG_TCGA-RY-A83X-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Multiple ductal cell_Pancreatic duct_Mouse CellMarker Gene-Cell Type Associations 1.0 null LN464 CCLE Cell Line Gene Expression Profiles 1.0 1.40797 GSE142684_3_v_5_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null RAB43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92933 dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.4299 ZNF207 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25239 EBF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.9512 H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null carbohydrate metabolism disease GWASdb SNP-Disease Associations 1.0 0.239251 Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.89409 PE01 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.56525 H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 LAMC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06184 GSE149442_1_v_0_gdpd3_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE138001_2_v_4_rorb_mouse RummaGEO Gene Perturbation Signatures 1.0 null SLR23 CCLE Cell Line Gene Expression Profiles 1.0 1.71084 NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09197 CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.849427 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MS-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Field CA3, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58592 SNU466 CCLE Cell Line Gene CNV Profiles 1.0 1.40014 H3K4me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null trunk TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053063 RFX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0349 sense organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null LMNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20453 NCIH1623 CCLE Cell Line Gene CNV Profiles 1.0 1.86239 primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.827724 hsa-miR-3689c TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 regulation of multicellular organismal development GO Biological Process Annotations 2015 1.0 null KMS34 CCLE Cell Line Gene CNV Profiles -1.0 -1.4511 Prostate adenocarcinoma_PRAD_TCGA-KK-A59Z-01A-12R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FU97 DepMap CRISPR Gene Dependency 1.0 2.36762 GSE210580_0_v_2_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Medial geniculate complex, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08881 skeletal system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.250301 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BTG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31316 ChIP_H3K27me3_17603471_mouseESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H413 DepMap CRISPR Gene Dependency 1.0 2.02302 GR-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1563 PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null superficial stratum of isLim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22306 KLF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45433 PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.899691 positive regulation of neuron differentiation GO Biological Process Annotations 2025 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A4IF-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Foxo1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.0824 TLDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03795 amygdaloid complex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.13994 Main olfactory bulb, mitral layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04489 GSE220693_1_v_0_cgas_mouse RummaGEO Gene Perturbation Signatures 1.0 null Ar JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.4617 NAALADL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47151 ventral subnucleus of MG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39125 hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.37047 GSE165174,GSE165175_0_v_2_trametinib_mouse RummaGEO Drug Perturbation Signatures 1.0 null MLXIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10539 cholestasis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.180367 superficial stratum of PPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19031 H3K4me1_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null positive regulation of neurogenesis GO Biological Process Annotations 2015 1.0 null organelle membrane GO Cellular Component Annotations 2015 1.0 null C11orf98 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22873 superficial dorsofrontal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.15433 hematopoietic stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.115213 MAPK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03673 GSE196110_1_v_2_ndrg3_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100504_TCx_probable Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.33917 striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.967844 Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.4076 20460173-ImmPortComprehensiveListofImmune-RelatedGenes GeneSigDB Published Gene Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71R-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51R-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A7J1-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_14493_KO_Cnot4_SRP285155 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 16.3527 Grb2-Sos complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.728 KLF14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 151.523 SNU410 CCLE Cell Line Gene CNV Profiles 1.0 2.10309 ChIP_TCFCP2L1_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null regulation of neuron differentiation GO Biological Process Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HW-7491-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.967804 NAMALWA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.963872 layer 5 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1424 parasitic protozoa infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.095801 GSE242199_6_v_7_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.22543 Perturb_10739_KD_Ddx3_SRP324914 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.92706 r1 part of principal trigeminal sensory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28165 molecular layer of S Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29256 Lymphoma_burkitts(Daudi) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.852226 MZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.0908 primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.47085 KMS-28PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.81801 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EGR2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.5228 TGFBR2_KO_GDS5008_282_mouse_Embryonic palatal mesenchymal cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ZNF454 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 127.124 superficial stratum of PCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03724 GSE198165,GSE198166_6_v_10_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null KCTD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07083 intermediate stratum of DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.18589 HSPA1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30372 outer CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.85077 Liver Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.47322 SUZ12 ChEA Transcription Factor Targets 1.0 null hsa-miR-525-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 PMC4860404-Table1.XLSX-MR_unique-Table_S1-7_DEG_unique_in_mouse_and_rat_SCI_at_1_dpi_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.50721 Breast Neoplasms CTD Gene-Disease Associations 1.0 1.47813 hsa-miR-193a-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.283838 Paracentral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07536 GSE237666,GSE237688_1_v_2_igf2bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null FAM229A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63719 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.888849 GSE183251_7_v_5_cyp2c70_mouse RummaGEO Gene Perturbation Signatures -1.0 null regulation of Ras protein signal transduction GO Biological Process Annotations 2023 1.0 null ZNF740 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 121.074 SKMES1 CCLE Cell Line Gene CNV Profiles 1.0 1.3553 Acute Myeloid Leukemia_LAML_TCGA-AB-3007-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3458-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HPS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13422 SP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35816 H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ChIP_H3K27me3_20682450_humanESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null ascites TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.36526 GSE201454_1_v_4_ftcd_mouse RummaGEO Gene Perturbation Signatures -1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null membrane part GO Cellular Component Annotations 2015 1.0 null monocytic leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.194936 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null phosphorylation GO Biological Process Annotations 2015 1.0 null type ii diabetes mellitus GWASdb SNP-Phenotype Associations 1.0 0.458315 Perturb_9498_KO_Lsd1_SRP096254 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 14.9504 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HUT102 CCLE Cell Line Gene Expression Profiles -1.0 -1.60584 GSE237040_2_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null HCC2218 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.807035 RASSF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57708 KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08196 Perturb_11056_KD_Eif4ebp3_SRP251186 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 cascade GeneRIF Biological Term Annotations 1.0 null putamen, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.53954 DLX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61451 Somatosensory areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34408 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4XL-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CAMSAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07204 BMS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70986 regulation of primary metabolic process GO Biological Process Annotations 2015 1.0 null KDM5B ENCODE Transcription Factor Targets 1.0 null GSE196104,GSE196106_2_v_1_vsx2_mouse RummaGEO Gene Perturbation Signatures -1.0 null membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GSE210682_2_v_1_methadone_human RummaGEO Drug Perturbation Signatures -1.0 null Precancerous Conditions CTD Gene-Disease Associations 1.0 1.13552 H3K27me3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J7-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10509 metabolic process GO Biological Process Annotations 2015 1.0 null Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Brain Lower Grade Glioma_LGG_TCGA-TM-A84M-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pancreas disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.081302 Disease Models, Animal CTD Gene-Disease Associations 1.0 1.24056 Rectum adenocarcinoma_READ_TCGA-EI-6513-01A-21R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH82 CCLE Cell Line Gene Expression Profiles 1.0 2.71531 H3K27me3_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE196699_4_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null Nucleus of the lateral lemniscus, horizontal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22692 501A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.899691 positive regulation of protein metabolic process GO Biological Process Annotations 2015 1.0 null organelle LOCATE Predicted Protein Localization Annotations 1.0 null regulation of neuron differentiation GO Biological Process Annotations 2023 1.0 null JHUEM3 CCLE Cell Line Gene CNV Profiles -1.0 -1.43097 PMC6607928-iovs-60-07-32_file_S11.xlsx-no_change_NRL_mutants-latefoetal_NRL Rummagene Transcription Factor Associations 2026 1.0 null PMC4860404-Table1.XLSX-MR_specific-Table_S1-9_DEGspecific_for_mouse_rat_SCI_at_1_dpi_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null SHARPIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50295 regulation of cell differentiation GO Biological Process Annotations 2015 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.56053 ALG5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15988 EOGT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49769 SRSF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48144 GSE242199_6_v_0_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE173262_2_v_0_ash1l_mouse RummaGEO Gene Perturbation Signatures -1.0 null Astrocyte_Brain_Mouse CellMarker Gene-Cell Type Associations 1.0 null primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.836517 PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS Rummagene Transcription Factor Associations 2026 1.0 null PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Pneo-r__CIC-1n_h-r__CIC-2n_h-r_CIC Rummagene Transcription Factor Associations 2026 1.0 null BAD-BCL-2 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.713 PMC11801220-NIHMS2038999-supplement-15.xlsx-Exc-MAF-gene_MAF Rummagene Transcription Factor Associations 2026 1.0 null Miyoshi muscular dystrophy 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.432 ZNG1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61644 amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00442 nerve GTEx Tissue Gene Expression Profiles 1.0 0.928365 intermediate stratum of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54876 EIF2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.13092 YTHDF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73922 posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.83537 orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.974461 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null nucleus accumbens, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.52229 superficial stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07533 HBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03876 eye cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null posteroventral (inferior) parietal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.27327 cell part LOCATE Predicted Protein Localization Annotations 1.0 null Hoxd13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.614 PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-female_port-FOS_FOS Rummagene Transcription Factor Associations 2026 1.0 null regulation of molecular function GO Biological Process Annotations 2015 1.0 null HSC4 CCLE Cell Line Gene CNV Profiles 1.0 1.45834 NCI-H28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.920689 OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1563 female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052007 KIF4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27838 TCP10L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.26109 CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ROCK_INHIBITION_GDS3944_464_mouse_Forebrain astrocytes - 24 Hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null positive regulation of cell differentiation GO Biological Process Annotations 2025 1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KDM5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.6998 Lateral habenula Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09413 GSE184210_0_v_3_glucagon_mouse RummaGEO Drug Perturbation Signatures -1.0 null posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.852645 NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.14193 Perturb_16097_KO_Eed_SRP125082 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GSE123372,GSE123373_10_v_2_mecp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null regulation of nervous system development GO Biological Process Annotations 2015 1.0 null GSE70499_3_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2089 GSE211983_0_v_2_nicotine_mouse RummaGEO Drug Perturbation Signatures 1.0 null regulation of cell development GO Biological Process Annotations 2015 1.0 null NCI-H1734 COSMIC Cell Line Gene Mutation Profiles 1.0 null hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.920225 leukocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.076889 GSE169263_1_v_0_armc5_mouse RummaGEO Gene Perturbation Signatures -1.0 null OV56 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.940378 Brain Lower Grade Glioma_LGG_TCGA-HT-A619-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gingiva TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.217554 MFE-319 COSMIC Cell Line Gene Mutation Profiles 1.0 null posteroventral (inferior) parietal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.89267 UOK101 CCLE Cell Line Gene Expression Profiles 1.0 1.46844 extracellular region part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.049264 Perturb_11250_KO_Med23_SRP027536 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 13.3894 UNC13B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74371 Uterine Cervical Neoplasms CTD Gene-Disease Associations 1.0 1.03939 primary motor cortex (area M1, area 4)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.982574 HS746T COSMIC Cell Line Gene Mutation Profiles 1.0 null VAX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70696 Crus I, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.855527 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.61326 DGCR6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34128 CEBPB ENCODE Transcription Factor Targets 1.0 null GSE154767_4_v_5_adam10_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE129389_0_v_6_tropifexor_mouse RummaGEO Drug Perturbation Signatures -1.0 null Perturb_10712_KO_Nrf2_SRP336215 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.07988 OE33 Achilles Cell Line Gene Essentiality Profiles 1.0 1.17766 JUND ENCODE Transcription Factor Targets 1.0 null Perturb_8019_KO_Cblif_ERP002279 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.4799 HINFP JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.3752 medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.46454 RBM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53703 Tobacco Use Disorder HuGE Navigator Gene-Phenotype Associations 1.0 null NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02131 Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.85627 coccidiosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.453339 Field CA3, stratum lucidum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63302 regulation of protein metabolic process GO Biological Process Annotations 2015 1.0 null PPP1R10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44004 VIIIA Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.999119 NCIH2887 DepMap CRISPR Gene Dependency 1.0 2.03323 Mammary Neoplasms, Animal CTD Gene-Disease Associations 1.0 1.18587 transferase activity, transferring phosphorus-containing groups GO Molecular Function Annotations 2015 1.0 null positive regulation of response to stimulus GO Biological Process Annotations 2015 1.0 null ZCCHC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.41303 SREBF2 JASPAR Predicted Transcription Factor Targets 1.0 null H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null ADGRL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71826 GSE125007,GSE125008_10_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GPI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88897 X, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.27918 superficial stratum of VTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28183 S1P_Deficiency_GDS3654_521_mouse_Liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Perturb_4425_KO_Eed_SRP172483 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.164 GSE147664_0_v_1_arid1b_mouse RummaGEO Gene Perturbation Signatures -1.0 null BC3C CCLE Cell Line Gene Expression Profiles -1.0 -1.98163 Posterior parietal association areas, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38527 CGTHW1 CCLE Cell Line Gene CNV Profiles 1.0 2.31005 PHF8 ENCODE Transcription Factor Targets 1.0 null mRNA_SOX9_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17641 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RQ-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KYSE-70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02328 regulation of cellular localization GO Biological Process Annotations 2025 1.0 null periventricular stratum of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52807 Nfatc2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 36.1306 tfap2c_18353300_e16dot5_skin_lof_mouse_gpl1261_gds3171 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.082736 urinary bladder HPA Tissue Protein Expression Profiles 1.0 1.26736 MINDY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56496 mantle zone of PcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79099 RPL37A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13134 head of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.15825 EFNA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.83218 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null XRCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12926 Perturb_227_KO_Pet1_SRP194283 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 18.7696 membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 protein kinase activity GO Molecular Function Annotations 2015 1.0 null HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.794 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.430076 Viscus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 SEM CCLE Cell Line Gene CNV Profiles -1.0 -1.5024 NCIH1838 CCLE Cell Line Gene CNV Profiles 1.0 2.05213 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null outer CP in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01288 lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.933193 HES5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.86 Organelle membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 CAL-85-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.977938 intermediate stratum of r3BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23261 Autosomal recessive limb-girdle muscular dystrophy type 2L DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.412 dorsorostral division of MFC (area 32) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02552 Nucleus of the lateral lemniscus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10187 H3K27me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-516a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 TENT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32226 r6 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16019 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hematopoietic cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.308251 RPL31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13927 CHST7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.87615 GSE237040_6_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures 1.0 null eye TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null glial cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null TOMM22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.13284 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29T-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.47564 H3K27me3_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NOMO1 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.45522 H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.43416 mRNA_ESX1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null TGFBR2_knockout_292_GSE46150 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.66082 hsa-miR-4520a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 GSE160373_5_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null MTRES1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07783 TSEN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22166 posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04112 Rectum adenocarcinoma_READ_TCGA-AF-2691-11A-01R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ES4 DepMap CRISPR Gene Dependency 1.0 3.20268 Edema CTD Gene-Disease Associations 1.0 1.24433 r9 part of trigeminal transition zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11194 positive regulation of catalytic activity GO Biological Process Annotations 2015 1.0 null occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.2764 striatum_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19947 H3K27ac_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Main olfactory bulb, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.25137 outer CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.957943 hsa-miR-632 TargetScan Predicted Conserved microRNA Targets 1.0 0.181316 ARHGAP27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58979 perinuclear region of cytoplasm GO Cellular Component Annotations 2015 1.0 null 496100312_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.61074 GSE232218_1_v_0_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Pparg::Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.8002 r3 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.77951 Posterior parietal association areas, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13705 CEP55 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7244 lateral part of the lateral habenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07081 POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nasopharynx HPA Tissue Protein Expression Profiles 1.0 1.26736 GSE219195_1_v_3_rbm12_human RummaGEO Gene Perturbation Signatures -1.0 null Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.098 all GWASdb SNP-Phenotype Associations 1.0 0.029636 H3K4me3_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null amygdaloid complex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.988153 ZNF699 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23348 Lung squamous cell carcinoma_LUSC_TCGA-21-5782-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HSD17B10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.6534 rosiglitazone_mus musculus_gpl7202_gse19896 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KLF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 124.855 GSE142210_11_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null molecular layer of the DG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.04775 inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.985337 UBAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29869 ATP6V0B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54774 neuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.253127 Primary B cells from cord blood Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 2.23457 SAP18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30657 GSE153757,GSE153758_1_v_3_ftsj1_mouse RummaGEO Gene Perturbation Signatures -1.0 null EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF311 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72231 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.884322 NBN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30776 GSE211983_1_v_2_nicotine_mouse RummaGEO Drug Perturbation Signatures 1.0 null RPS9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23608 regulation of cellular metabolic process GO Biological Process Annotations 2015 1.0 null FU-OV-1 COSMIC Cell Line Gene CNV Profiles -1.0 -3.40381 mRNA_NR2F2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.864673 TestisGermCell BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.87912 Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71U-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary auditory cortex (core)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.984769 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5098-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PA-TU-8902 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.920689 posterior intralaminar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.03535 FAM53C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1434 STAT3-18555785-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043573 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CYB5D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.96507 PMC4815041-NIHMS715090-supplement-Supplementary_Table_10.xlsx-CCF_DP_clustering-Hugo_Symbol_PITX1 Rummagene Transcription Factor Associations 2026 1.0 null lung TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.274394 MARCKSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22174 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PAPSS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.0682 HUT78 CCLE Cell Line Gene CNV Profiles -1.0 -1.47736 disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.049248 CTCF_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPARG ChEA Transcription Factor Targets 1.0 null TAF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8879 18285497-tableS1 GeneSigDB Published Gene Signatures 1.0 null KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periaqueductal gray substance, dorsolateral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.928082 ATP5MC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56087 FBXO17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14036 SG in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.972993 Perturb_13829_OE_SETD4_SRP367523 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 Field CA3, stratum oriens Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27302 CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Tongue BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.48386 golgi apparatus COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 Neoplasm Metastasis CTD Gene-Disease Associations 1.0 1.21337 CHP126 CCLE Cell Line Gene CNV Profiles -1.0 -1.84783 GSE231524,GSE231526_0_v_1_dusp6_human RummaGEO Gene Perturbation Signatures 1.0 null PF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89749 SP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.884478 GSE144231_3_v_5_cxcr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE63048_11_v_5_morc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SKBR3 DepMap CRISPR Gene Dependency 1.0 2.93466 gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.05041 GSE191105_2_v_3_nat1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE214596,GSE214598_1_v_0_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 15750623-Table1 GeneSigDB Published Gene Signatures 1.0 null PRR35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4966 Cardiovascular Diseases CTD Gene-Disease Associations 1.0 1.26947 RAD6-UBR2 ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.281 paralemniscal isthmic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3886 H3K27me3_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2663 Brain Lower Grade Glioma_LGG_TCGA-S9-A6U2-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC25A32 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72709 H3K27me3_cardiac mesoderm_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null phagocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.137455 H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Z-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53816 primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.994105 N4BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09805 inner CP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.888226 CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4153-01B-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cellular anatomical entity COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Golgi membrane GO Cellular Component Annotations 2025 1.0 null HSPB8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33015 SNUC1 DepMap CRISPR Gene Dependency 1.0 5.03647 COLO684 CCLE Cell Line Gene Expression Profiles 1.0 2.15664 CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01052 Adrenocortical carcinoma_ACC_TCGA-OR-A5LS-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null III Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13739 hsa-miR-520a-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 cingulate gyrus, parietal part, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.84688 Prdm15 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 48.6258 dorsal lateral geniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20836 intermedioposterior nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28559 IV, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.893384 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE178113,GSE178116_0_v_1_atrx_mouse RummaGEO Gene Perturbation Signatures -1.0 null RBIS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58344 CTCF_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE169713,GSE169715_1_v_2_tert_mouse RummaGEO Gene Perturbation Signatures -1.0 null ATP5ME CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77994 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5201-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null motor nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.839653 H3K27me3_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE223334_1_v_2_bcl11b_mouse RummaGEO Gene Perturbation Signatures 1.0 null Nfatc1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 42.0305 Perturb_14685_KO_Lkb1_ERP006813 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 PCNX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.41109 TIA1_KO_GSE54418_262_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RI-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4252 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.962187 hsa-miR-3200-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 Intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 ETV5::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.939 regulation of protein phosphorylation GO Biological Process Annotations 2015 1.0 null LXF-289 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67225 respiratory system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.259254 MYC_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null regulation of phosphorus metabolic process GO Biological Process Annotations 2015 1.0 null C2BBE1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.899206 H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null E2F6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 63.2309 MCAD_KO_GDS4546_423_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null zona incerta Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.863145 cyst TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.258917 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.64956 H3K27me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050486 MT-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.847677 GSE125007,GSE125008_5_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null intermediate stratum of r8Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19366 JK1 CCLE Cell Line Gene CNV Profiles -1.0 -1.55372 SUPT1 CCLE Cell Line Gene Expression Profiles 1.0 1.37488 PWR-1E COSMIC Cell Line Gene Mutation Profiles 1.0 null JSC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.231102 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NK-A5D1-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Antennal gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.969 CHD1 ENCODE Transcription Factor Targets 1.0 null PMC9170821-JCMM-26-3183-s001.xlsx-Neu_DAPI_ERG_VaDadj_vs_NC-Gene_ERG Rummagene Transcription Factor Associations 2026 1.0 null FAM98B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63766 THUMPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11132 PTGR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53292 ventromedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24984 neuromuscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.392629 H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null DBH_KO_GSE33906_53_mouse_heart (E10.5) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K27me3_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.44004 hsa-miR-720 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GSE198165,GSE198166_5_v_10_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.40051 GSE211177,GSE211178_9_v_11_ets1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PEA1 DepMap CRISPR Gene Dependency 1.0 4.52663 CD33+_Myeloid BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.898734 BCS1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86374 Medial geniculate complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06034 Distal myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.925 MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 2.3423 Bounding membrane of organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 RUNX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00319 Lung squamous cell carcinoma_LUSC_TCGA-60-2698-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ACO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80652 ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.833307 KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05503 LU-135 COSMIC Cell Line Gene Mutation Profiles 1.0 null Nfat5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 45.6067 positive regulation of developmental process GO Biological Process Annotations 2015 1.0 null POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KLF5 JASPAR Predicted Transcription Factor Targets 1.0 null GSE173262_6_v_0_ash1l_mouse RummaGEO Gene Perturbation Signatures -1.0 null WM793 CCLE Cell Line Gene Expression Profiles -1.0 -2.08187 ES-I3 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.21295 GSE116894_1_v_0_tle3_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null protein phosphorylation GO Biological Process Annotations 2015 1.0 null hsa-miR-3673 TargetScan Predicted Conserved microRNA Targets 1.0 0.265648 OB glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.14113 positive regulation of molecular function GO Biological Process Annotations 2015 1.0 null Perturb_11260_KO_Hur_SRP396792 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.16904 D341MED CCLE Cell Line Gene Expression Profiles 1.0 1.9338 IM-95 COSMIC Cell Line Gene Mutation Profiles 1.0 null DES CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26508 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null hsa-miR-330-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Eyestalk TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.144 EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE176093_2_v_3_mineral oil_mouse RummaGEO Drug Perturbation Signatures -1.0 null outer CP in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.978162 positive regulation of multicellular organismal process GO Biological Process Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4TA-01A-21R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE246053_1_v_2_hnf4a_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.32741 marrow cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.125113 ZSCAN31 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.6577 ZSCAN4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.2504 catalytic activity GO Molecular Function Annotations 2015 1.0 null DNAAF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65911 midbrain raphe nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.12706 RNA helicase p68_KD_GDS2152_626_mouse_skeletal muscle cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null SF295 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.3696 posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.86715 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RO-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBR1-RAD6 ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.243 JHOM2B CCLE Cell Line Gene Expression Profiles -1.0 -1.82619 PRDM16_DEPLETION_GDS4021_460_mouse_WAT - white adipose tissue (stromal-vascular cells) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.858947 CHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31588 SH3BGRL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45716 ERRalpha_Deficiency_GDS2727_646_mouse_Heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null MZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.968429 hsa-miR-4741 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 CL11 DepMap CRISPR Gene Dependency 1.0 2.26468 SUM1315MO2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.850112 H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null positive regulation of cell differentiation GO Biological Process Annotations 2015 1.0 null PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF Rummagene Transcription Factor Associations 2026 1.0 null abdomen TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.073607 MCAS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.858947 F8A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52433 mRNA_SOX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null RPS15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40092 PGS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54551 Perturb_11242_KO_Sirt6_SRP190930 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.87137 Lung adenocarcinoma_LUAD_TCGA-55-8096-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EYA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5258 interstitial nucleus of the zona limitans Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.34957 H3K27me3_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null sp3_17923686_e12dot5_heart_lof_mouse_gpl1261_gds3058 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.815015 D502MG DepMap CRISPR Gene Dependency 1.0 4.27749 internal segment of globus pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50274 hsa-miR-206 TargetScan Predicted Conserved microRNA Targets 1.0 0.568687