association dataset threshold value standardized value U-698-M Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.00539 NCIH1623 CCLE Cell Line Gene Expression Profiles -1.0 -2.71915 NCIH2141 CCLE Cell Line Gene Expression Profiles 1.0 1.52517 CTCF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-211 TargetScan Predicted Conserved microRNA Targets 1.0 0.199275 CTCF_fibroblast of pedal digit skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.83888 YY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16063 FLOT2 Pathway Commons Protein-Protein Interactions 1.0 null layer 2 of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51603 NDUFB8 Pathway Commons Protein-Protein Interactions 1.0 null ONE58 DepMap CRISPR Gene Dependency 1.0 2.19849 GTEX-TMMY-0626-SM-33HBD GTEx Tissue Sample Gene Expression Profiles 1.0 1.60487 HS611T CCLE Cell Line Gene Expression Profiles -1.0 -1.50283 POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU638 DepMap CRISPR Gene Dependency 1.0 2.29157 PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-OLIG2_UNIQUE_DYS_GENES-OLIG2_TLE_vs_TL_log2FoldChange_1_padj_0_1_OLIG2 Rummagene Transcription Factor Associations 2026 1.0 null PMC7616986-EMS181817-supplement-Supplemenatry_tables.pdf-187-ZNF222_ZNF222 Rummagene Transcription Factor Associations 2026 1.0 null shell of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16238 molecular_function GO Molecular Function Annotations 2015 1.0 null H3K9ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T8EM-1626-SM-3DB7K GTEx Tissue Sample Gene Expression Profiles 1.0 2.02425 OV56 CCLE Cell Line Gene Expression Profiles -1.0 -1.56763 GTEX-XBED-1126-SM-48TCF GTEx Tissue Sample Gene Expression Profiles 1.0 1.34514 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.74864 mantle zone of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42798 SKES1 CCLE Cell Line Gene CNV Profiles 1.0 1.87555 HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.21597 orbital frontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.59425 H3K79me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-ND-A4WF-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH1781 CCLE Cell Line Gene CNV Profiles 1.0 1.56494 GTEX-QMRM-1726-SM-2S1QG GTEx Tissue Sample Gene Expression Profiles 1.0 1.08458 hsa-miR-3136-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.766596 gata1_15895080_e12dot5_liver_megakaryocyte_lof_mouse_gpl1261_gds1316 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.756885 GTEX-PWO3-0005-SM-2I5FS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20784 GTEX-U3ZM-0326-SM-4DXUJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.14644 GTEX-NL3H-0011-R7a-SM-2I3G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.883498 GTEX-S32W-0426-SM-4AD6H GTEx Tissue Sample Gene Expression Profiles 1.0 1.13128 GSE48812_11_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null lateral hypothalamic area, mammillary region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.27311 GSE179031_3_v_1_foxp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Cytoplasmic vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 GTEX-Q2AG-0011-R9A-SM-2HMJ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.835199 GTEX-X8HC-0006-SM-46MV6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29969 cos-7 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.62991 GTEX-OHPL-3026-SM-3MJGS GTEx Tissue Sample Gene Expression Profiles 1.0 1.20255 GSE161864,GSE161866_1_v_3_ror2_human RummaGEO Gene Perturbation Signatures -1.0 null JHOS4 CCLE Cell Line Gene CNV Profiles -1.0 -1.57679 hsa-miR-4676-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.085563 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4804-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GTEX-POMQ-0006-SM-33HBY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09253 postcentral gyrus, left, bank of the central sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.845361 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SDHAF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32413 TGW DepMap CRISPR Gene Dependency 1.0 2.20754 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81P-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tretinoin_homo sapiens_gpl6244_gds4180 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2IR-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.44469 MTCH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27841 MCF7_Regorafenib_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0124642 CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT5A ENCODE Transcription Factor Targets 1.0 null H3K9ac_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UTHO-0006-SM-3NMCC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.896421 Rabies CVS-11_7day-Spinalcord_22116324_GSE30577 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.11738 hsa-miR-122 TargetScan Predicted Conserved microRNA Targets 1.0 0.766596 UTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22956 CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null LMAN1 Pathway Commons Protein-Protein Interactions 1.0 null IGR1 DepMap CRISPR Gene Dependency 1.0 2.02672 H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.28528 marrow cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.111209 OV7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.844092 GSE233679_6_v_11_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null ATF3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null paraventricular nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.5575 Lung squamous cell carcinoma_LUSC_TCGA-60-2726-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sec62/Sec63 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.583 Mixed ProteomicsDB Cell Type and Tissue Protein Expression Profiles 1.0 1.04724 H3K4me1_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Pith TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.525 GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5705 GTEX-RVPU-0011-R3A-SM-2XCAE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.942533 JEKO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 2.07114 TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 496100574_HIP_possible Alzheimer's disease_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.02797 GTEX-PLZ6-0226-SM-3P61I GTEx Tissue Sample Gene Expression Profiles -1.0 -0.893363 dexamethasone_homo sapiens_gpl4133_gse42619 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2AphosphoS2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EW8 CCLE Cell Line Gene CNV Profiles -1.0 -1.67084 GSE225647_1_v_3_srsf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZZ-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anterior cingulate area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17071 ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.974447 GTEX-WYVS-2526-SM-3NMAT GTEx Tissue Sample Gene Expression Profiles 1.0 1.50267 SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12864_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLI1::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.9199 RUNX3 ENCODE Transcription Factor Targets 1.0 null inorganic cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null JHOS2 CCLE Cell Line Gene CNV Profiles 1.0 1.78557 laticifer TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.780232 GSE81193_3_v_5_irf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null 8856_TFR2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.504449 Prostate adenocarcinoma_PRAD_TCGA-EJ-7125-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11385078-jciinsight-9-172336-s278.xlsx-Sheet1-Supplementary_Table_4_A_Differential_proteins_from_AA_BLCA_and_EA_BLCA_tissues_using_mass_spectrometry_based_proteomics_analysis_from_Figure_1C_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null intermediate stratum of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27221 ATF2_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE157383_6_v_1_abemaciclib_human RummaGEO Drug Perturbation Signatures -1.0 null intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 primary motor cortex (area M1, area 4)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.20167 GTEX-XAJ8-1226-SM-47JYS GTEx Tissue Sample Gene Expression Profiles 1.0 1.2988 r2 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30951 cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.928285 MCF7_Quercetin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0155724 ventral premammillary nucleus (migrated) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41381 MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM83E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.40853 Perturb_2519_KD_ZNF414_SRP269946 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 PMC2263127-pone.0001816.s002.xls-Terms_with_Genes_E2F3_up_Bild-Title_E2F3 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null CTCF_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QMR6-1926-SM-32PL9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.933256 GTEx Skin 20-29 vs 70-79 GTEx Tissue-Specific Aging Signatures -1.0 -6.35322 cytoplasmic part GO Cellular Component Annotations 2015 1.0 null Retrosplenial area, lateral agranular part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04257 Perturb_174_KD_Asns_SRP119931 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 CTCF_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.82996 testis_7b HPA Tissue Sample Gene Expression Profiles -1.0 -1.46055 BRCA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Telencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 lingual gyrus, left, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.889952 HCC1359 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67349 GSE226114,GSE226116_1_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A94X-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HUH7 CCLE Cell Line Gene Expression Profiles -1.0 -1.6046 GTEX-S7SE-0011-R1A-SM-2XCDE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.931854 GSE140936,GSE140938_2_v_1_slfn11_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_fibroblast of lung_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-0126-SM-3TW8O GTEx Tissue Sample Gene Expression Profiles -1.0 -2.1495 amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.09836 TMSB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24534 GTEX-RNOR-0426-SM-2TF4U GTEx Tissue Sample Gene Expression Profiles 1.0 1.40951 SP in rostral midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.907966 orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.923066 endosome GO Cellular Component Annotations 2015 1.0 null UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.36377 ERLEC1 Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A619-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null occipital pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.09392 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_cardiac fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74845 HCC1171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03299 GSE132369,GSE132371_2_v_0_cccp_human RummaGEO Drug Perturbation Signatures 1.0 null GSE155031_5_v_0_dextran_human RummaGEO Drug Perturbation Signatures -1.0 null metal ion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null NR3C1 JASPAR Predicted Transcription Factor Targets 1.0 null early endosome GO Cellular Component Annotations 2023 1.0 null Forebrain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.049628 496100622_HIP_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.07635 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6227-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE230174_0_v_1_dagla_human RummaGEO Gene Perturbation Signatures -1.0 null Organelle subcompartment COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE217694_3_v_2_pold1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A264-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_5047_KO_SYTL3_ERP126655 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-R55G-2126-SM-2TC67 GTEx Tissue Sample Gene Expression Profiles 1.0 0.946745 GSE100316_7_v_1_mtor_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4733-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GSE159678_6_v_2_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null TCF7L2_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1576 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.42013 H3K4me3_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null COR-L26 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.17753 r3 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.63117 A-CA-04-2009(H1N1)MA_Day3_22532695_GSE36328 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.39499 MPV17 Pathway Commons Protein-Protein Interactions 1.0 null fibroblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.088145 Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.072 H3K9me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-QQ-A8VF-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE254517_1_v_0_irf7_mouse RummaGEO Gene Perturbation Signatures 1.0 null MZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.953342 GSE221356_1_v_0_tfeb_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_cerebellum_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12631 GTEX-X88G-0426-SM-47JZ5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.35212 STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER ChEA Transcription Factor Targets 2022 1.0 null GTEX-XPT6-1626-SM-4B655 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30704 gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.100075 FOXO1::FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.2702 Brain Lower Grade Glioma_LGG_TCGA-HT-7692-01A-12R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null outer SZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15563 SNRK_overexpression_127_GSE30185 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.59848 CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE145311_0_v_2_glutathione_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-T2IS-0426-SM-32QPE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29125 NUP160 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38622 MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null DD-75-HY40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.272828 GSE125153_1_v_0_bcl3_mouse RummaGEO Gene Perturbation Signatures -1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.888998 shell of T-DMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31118 CTCF ENCODE Transcription Factor Targets 1.0 null PANK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24374 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.51857 intracellular membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.055718 Lung adenocarcinoma_LUAD_TCGA-49-4507-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TKQ1-0926-SM-4DXU2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52408 GTEX-XGQ4-2026-SM-4AT6G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63919 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AZ-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Entorhinal area, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06704 NANOG ChEA Transcription Factor Targets 1.0 null STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null GTEX-QMR6-0011-R8A-SM-32PKJ GTEx Tissue Sample Gene Expression Profiles 1.0 2.03627 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-454 TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03008 H3K27ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE199541_2_v_4_mbd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Ventral part of the lateral geniculate complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72661 Adrenocortical carcinoma_ACC_TCGA-OR-A5JY-01A-31R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null external part of AOV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26428 Primary visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2504 4959_MED9_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.53928 POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPJH-0126-SM-4IHLL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49383 GSE199899_4_v_0_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE162276_2_v_3_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null External side of cell outer membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.56 GSE242333_0_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null Trichorhinophalangeal syndrome type II DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.089 hsa-miR-513c TargetScan Predicted Conserved microRNA Targets 1.0 0.348832 ZNF669 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.485 divalent inorganic cation transport GO Biological Process Annotations 2015 1.0 null kidney HPA Tissue Protein Expression Profiles 1.0 0.885014 Sarcoma_SARC_TCGA-DX-A6B7-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 1 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.76694 hematopoietic stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.102537 U937 DepMap CRISPR Gene Dependency 1.0 2.37435 Acute Myeloid Leukemia_LAML_TCGA-AB-2814-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29T-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1954 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01253 KLF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 140.269 GTEX-SIU8-0006-SM-2XCE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.955562 CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-W5WG-2726-SM-4LMIC GTEx Tissue Sample Gene Expression Profiles 1.0 1.21324 MKN-45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.841294 H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20Q-11A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE169571_5_v_4_dexamethasone_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02112 7454_RPL27A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.75653 hsa-miR-3935 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Shell gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.618 Perturb_15535_KD_Ash1l_SRP366889 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-ATF3_TGAYRTCA_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null TCTN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26847 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10109 IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.21156 Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV7-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pupal wing TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.604 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SJXC-0005-SM-2XCE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.999339 GTEX-PX3G-1026-SM-48TZW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11601 GSE210476_2_v_8_rutaecarpine_human RummaGEO Drug Perturbation Signatures -1.0 null SIN3A ENCODE Transcription Factor Targets 1.0 null inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.941578 JUN ENCODE Transcription Factor Targets 1.0 null GTEX-XBEC-1326-SM-4AT69 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.91105 Miscellaneous transport and binding events Reactome Pathways 2024 1.0 null POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null magnesium ion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null GSE160817_3_v_6_slamf6_human RummaGEO Gene Perturbation Signatures -1.0 null GSE158834_12_v_4_palm_human RummaGEO Gene Perturbation Signatures 1.0 null nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null POLR2A_K562_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.50356 GSE203308_14_v_0_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null isoproterenol hydrochloride_rattus norvegicus_gpl1355_gse7999 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Liver Neoplasms CTD Gene-Disease Associations 1.0 1.18456 H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Intrinsic component of external side of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.155 GTEX-X5EB-1026-SM-46MVU GTEx Tissue Sample Gene Expression Profiles 1.0 0.840329 CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary somatosensory area, lower limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13327 H3K4me3_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-WCDI-0426-SM-4GIAL GTEx Tissue Sample Gene Expression Profiles 1.0 1.42055 diethylstilbestrol_rattus norvegicus_gpl1355_brown norway_gds2913 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2842-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HIC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.4445 GTEX-P4QS-1826-SM-2S1NI GTEx Tissue Sample Gene Expression Profiles 1.0 0.89799 IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02757 SET-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.986126 CREM-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3646 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 Cytosolic region COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.407 HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE179002_3_v_8_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE165689_0_v_1_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null D423MG DepMap CRISPR Gene Dependency 1.0 2.39365 EIF5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4427 hsa-miR-202 TargetScan Predicted Conserved microRNA Targets 1.0 0.419947 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4146-01B-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUDHL10 CCLE Cell Line Gene CNV Profiles 1.0 2.59998 IGF1R_knockout_151_GSE32936 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.24214 GTEX-U3ZH-1726-SM-3DB79 GTEx Tissue Sample Gene Expression Profiles 1.0 1.69328 protein complex GO Cellular Component Annotations 2015 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5517-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE180147_0_v_1_itga5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE148066,GSE157787_8_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-S33H-2426-SM-2XCB2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24376 Anterior hypothalamic nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32536 GSE171311_0_v_1_ellagic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.64213 endoplasmic reticulum LOCATE Predicted Protein Localization Annotations 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6410-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CREB1 ENCODE Transcription Factor Targets 1.0 null GSE241036_4_v_1_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-T6MO-1926-SM-32QOJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.92281 H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-VUSG-0126-SM-4KL1X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92721 BtuCD complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.953 H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14001 H3K9ac_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null methotrexate_homo sapiens_gpl570_gse11440 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-OOBJ-2126-SM-3NB1N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29302 POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEx SmallIntestine 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures 1.0 4.85237 GTEX-X3Y1-0726-SM-3P5YU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.98047 medial group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.37978 Bone marrow cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 golgi apparatus part GO Cellular Component Annotations 2015 1.0 null ELK4 ENCODE Transcription Factor Targets 1.0 null macrophage TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.14805 H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null mantle zone of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03 H3K9ac_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1 ENCODE Transcription Factor Targets 1.0 null GTEX-U3ZN-2626-SM-3DB7T GTEx Tissue Sample Gene Expression Profiles 1.0 1.06655 Spleen Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.2196 H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prelimbic area, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.74679 H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.044473 OUMS27 CCLE Cell Line Gene Expression Profiles -1.0 -1.66935 PK-59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05525 superficial stratum of POH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03 POLR2A_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KIAA2013 Pathway Commons Protein-Protein Interactions 1.0 null doxorubicin_homo sapiens_gpl570_gse46493 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null dorsolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.4643 SG in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.93177 APP Pathway Commons Protein-Protein Interactions 1.0 null OAW28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.851279 orbital frontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.20281 GSE179002_0_v_8_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ6-1626-SM-3NB23 GTEx Tissue Sample Gene Expression Profiles 1.0 1.65133 PPARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.25 GTEX-TMMY-0526-SM-33HBC GTEx Tissue Sample Gene Expression Profiles 1.0 1.20471 GSE158834_2_v_4_palm_human RummaGEO Gene Perturbation Signatures 1.0 null H3K23me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE77795_2_v_1_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-RM2N-1326-SM-48FCW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06825 MTX2 Pathway Commons Protein-Protein Interactions 1.0 null cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null endometrium_8a HPA Tissue Sample Gene Expression Profiles 1.0 0.951674 GSE197555_1_v_3_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_HEK293_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPVG-2926-SM-4B66G GTEx Tissue Sample Gene Expression Profiles 1.0 1.32185 KLF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 134.584 S100A16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04942 PMC9314667-Table_1.xlsx-Regulons-STAT1_STAT1 Rummagene Transcription Factor Associations 2026 1.0 null intracellular part LOCATE Curated Protein Localization Annotations 1.0 null hsa-miR-4755-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.193083 CHD2 ENCODE Transcription Factor Targets 1.0 null olfactory bulb, principal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42988 External side of cell wall COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.641 8218_SNRNP27_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.632696 GTEX-RN64-2326-SM-48FDW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66394 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE132948,GSE132949_0_v_1_msi2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GB1 CCLE Cell Line Gene Expression Profiles 1.0 2.30839 NEUROD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.7967 SNU739 DepMap CRISPR Gene Dependency 1.0 2.2019 GSE186483_2_v_4_lrrk2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HUH6 DepMap CRISPR Gene Dependency 1.0 2.00011 CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Submedial nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62744 A673_BONE CCLE Cell Line Proteomics 1.0 2.35735 PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-gene_name_LTF Rummagene Transcription Factor Associations 2026 1.0 null GSE197571_3_v_1_foxm1_human RummaGEO Gene Perturbation Signatures 1.0 null connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056809 CTCF_MCF-7_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_BE2C_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -3.87377 SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE157904_0_v_1_doxorubicin_mouse RummaGEO Drug Perturbation Signatures 1.0 null CREB1-23762244-HIPPOCAMPUS-RAT ChEA Transcription Factor Binding Site Profiles 1.0 null ZNF484 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71091 PANC-04-03 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.07976 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer 1 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.33722 NCI-H2795 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.826399 K562_Selisistat_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0178031 GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles 1.0 0.949575 REST_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4954754-elife-15550-fig3-figsupp1-data1.xlsx-HSF1_Genes-Unnamed_12_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.14944 H3K27ac_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZI-0126-SM-3NB13 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.95318 H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MXI1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HCFC1_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary somatosensory area, trunk, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16997 Primary somatosensory area, trunk, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18849 liver_c HPA Tissue Sample Gene Expression Profiles -1.0 -0.870877 GSE135350_2_v_4_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE183251_4_v_0_cyp2c70_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary motor cortex (area M1, area 4)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.30543 hsa-miR-132 TargetScan Predicted Conserved microRNA Targets 1.0 0.265648 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7782-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-CS-4938-01B-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MEC1 DepMap CRISPR Gene Dependency 1.0 2.43499 GTEX-XYKS-0005-SM-4BRUD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.934163 Prostate adenocarcinoma_PRAD_TCGA-EJ-7330-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UJHI-1926-SM-3DB8Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.867651 CHD7_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RSV-A2_24Hour-KO_RSV_None_GSE18170 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -3.0323 integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051116 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KOPN-8 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -5.06256 Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RH-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null blood TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055689 H4K20me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2F4_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPK-2326-SM-3MJH2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03699 hsa-miR-302f TargetScan Predicted Conserved microRNA Targets 1.0 0.145356 (S)-Selisistat DeepCoverMOA Drug Mechanisms of Action 1.0 0.33 GSE99875_2_v_0_everolimus_human RummaGEO Drug Perturbation Signatures 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04211 GTEX-Q734-0426-SM-48TZX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32282 H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-668 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.25293 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NF-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4752 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TE-671 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.17 496100631_PCx_dementia_TBI_77_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.4066 SK-N-SH COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C3-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059459 CEBPD JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.4533 GSE114992,GSE114993_0_v_5_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01403 CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-518d-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GSE210580_0_v_1_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC5670203-41467_2017_1251_MOESM5_ESM.xlsx-differential_expressed_BCL6_tar-gene_id_BCL6 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9932992-mmc7.xlsx-S6E-Table_S6E_Per-gene_per-sample_AR_data_fibroblasts_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE127790_10_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE232558_0_v_1_fbxl12_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XQ3S-2726-SM-4BOP2 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.47599 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TFCP2L1 ChEA Transcription Factor Targets 1.0 null H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r6BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07775 dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.917025 female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE180200,GSE180201_15_v_11_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.02631 RHJT DepMap CRISPR Gene Dependency 1.0 2.38571 EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-939 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ4-0006-SM-2S1NY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13973 pancreas GTEx Tissue Gene Expression Profiles -1.0 -0.857198 GSE217526_0_v_1_parthenolide_human RummaGEO Drug Perturbation Signatures 1.0 null bonemarrow_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.24462 HEK-293FT cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.001 GTEX-RU72-0011-R9A-SM-2TF67 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.966013 cell part GO Cellular Component Annotations 2015 1.0 null primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.26156 GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.877338 Eye degenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.036 RAD21_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S33H-1226-SM-4AD69 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.971239 H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_retinal pigment epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.98127 KNS-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.50326 Gill filament TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.547 Retrosplenial area, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00777 PANC 04.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.11999 hsa-miR-4794 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 RAD21_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE124375_13_v_12_chd2_mouse RummaGEO Gene Perturbation Signatures 1.0 null cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-T8EM-1126-SM-3DB7D GTEx Tissue Sample Gene Expression Profiles 1.0 0.971 GTEX-QDVN-0826-SM-48TZ2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.938954 Uterine Carcinosarcoma_UCS_TCGA-NF-A4X2-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE116810_2_v_0_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null GSE264621_1_v_6_secretin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE121824,GSE121826_0_v_6_scaf8_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QEL4-1326-SM-447AD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34307 hsa-miR-130b TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 Signal recognition particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.445 ABC1 CCLE Cell Line Gene CNV Profiles 1.0 1.42956 GTEX-S33H-1626-SM-4AD68 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19908 GSE88819_1_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.86557 GSE120370_0_v_6_thrombin_mouse RummaGEO Drug Perturbation Signatures 1.0 null preoptic region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.62109 superficial stratum of PO1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.21222 H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U3ZN-2526-SM-3DB7V GTEx Tissue Sample Gene Expression Profiles 1.0 1.51692 Taenia tecta, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07108 outer CP in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.962702 hsa-miR-3657 TargetScan Predicted Conserved microRNA Targets 1.0 0.32519 H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC10244410-41467_2023_39054_MOESM5_ESM.xlsx-PIE-LIN28B-GeneSymbol_LIN28B Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BT474 CCLE Cell Line Gene Expression Profiles -1.0 -2.03957 SYMPK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75388 GSE196117_6_v_0_clarithromycin_human RummaGEO Drug Perturbation Signatures 1.0 null RFX5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE130383_2_v_3_gps2_mouse RummaGEO Gene Perturbation Signatures 1.0 null AD-51-FB60_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.209571 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5891-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU719 CCLE Cell Line Gene Expression Profiles -1.0 -3.99889 Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cingulate gyrus, retrosplenial part, left, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.90353 GSE135350_2_v_7_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null Posterior parietal association areas, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.18849 IZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.828878 MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04575 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E8-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.828336 GTEX-V955-1926-SM-4KL1L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21764 GTEX-QDT8-0426-SM-32PKZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.22255 GSE103068_5_v_4_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null ion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null ZNF669 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76197 Intrinsic component of organelle membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.94984 ZNF282 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3454 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Basolateral amygdalar nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12357 IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.90497 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PFN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04215 GSE186767_1_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE233679_6_v_4_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE151782_6_v_5_aim2_mouse RummaGEO Gene Perturbation Signatures 1.0 null TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH727 CCLE Cell Line Gene CNV Profiles -1.0 -1.87158 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XLM4-0011-R9A-SM-4AT45 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.900003 Anteromedial visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52926 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052896 H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null MM426 DepMap CRISPR Gene Dependency 1.0 2.23472 Transport of small molecules Reactome Pathways 2024 1.0 null H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PW2O-1426-SM-48TCD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44216 hsa-miR-217 TargetScan Predicted Conserved microRNA Targets 1.0 0.766596 intrinsic component of endoplasmic reticulum membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 egr1_20019881_retina_lof_mouse_gpl1261_gds3607 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.007687 divalent inorganic cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null H3K79me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SOX2-21211035-LN229-HUMAN ChEA Transcription Factor Targets 2022 1.0 null KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67V-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null CTCF_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCRT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70051 Lung adenocarcinoma_LUAD_TCGA-49-4490-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null single-organism process GO Biological Process Annotations 2015 1.0 null TWIST1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.1578 H3K4me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE193993_5_v_7_sstr2_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE62843,GSE64370_0_v_1_furan_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-R53T-0326-SM-48FEC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48973 Brain Lower Grade Glioma_LGG_TCGA-DU-8165-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VASN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08192 POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Orbital area, ventrolateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1376 POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Field CA3, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16506 hsa-miR-301b TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 microglial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.373118 GSE116810_5_v_1_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null mediodorsal nucleus of thalamus_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.909081 MAFK ENCODE Transcription Factor Targets 1.0 null H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null subthalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.83462 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.0906 Acute Myeloid Leukemia_LAML_TCGA-AB-2952-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null PLA2G4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10193 SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.42298 primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.08179 rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.98305 GTEX-X585-0011-R8A-SM-46MUX GTEx Tissue Sample Gene Expression Profiles 1.0 1.13748 Pancreatic adenocarcinoma_PAAD_TCGA-IB-7652-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S4Q7-1326-SM-4AD74 GTEx Tissue Sample Gene Expression Profiles 1.0 1.79896 GSE128232,GSE128233_1_v_0_phf2_human RummaGEO Gene Perturbation Signatures -1.0 null Endoplasmic reticulum protein-containing complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.785 ventrolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.13426 EIF4EBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16399 TXNDC5 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OCILY18 DepMap CRISPR Gene Dependency 1.0 2.42082 MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cos cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.500398 external part of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28653 GSE158834_12_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GSE190384,GSE190386_3_v_8_fulvestrant_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X62O-0008-SM-46MU5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.23012 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC3371315-NIHMS350140-supplement-8.xls-MCF7-T47D-SK-453_Down_MCF7-T47D-Supplementary_Table_1_ER-positive_FOXA1_signature_Genes_decreased_only_in_MCF7_and_T47D_cells_with_knockdown_of_FOXA1_FOXA1 Rummagene Transcription Factor Associations 2026 1.0 null GSE159049_1_v_0_sox2_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HINFP JASPAR Predicted Transcription Factor Targets 1.0 null NCI-H2106 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.45749 HUH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827595 GTEX-U3ZN-0526-SM-4DXTH GTEx Tissue Sample Gene Expression Profiles 1.0 0.824583 KARPAS422 DepMap CRISPR Gene Dependency 1.0 2.00174 MV411 DepMap CRISPR Gene Dependency 1.0 2.15284 GTEX-S4Z8-2026-SM-3K2A9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.35978 POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null estradiol_mus musculus_gpl4134_gse23241 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-0007-SM-2D7W1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.995963 IZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.870017 H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null FU97 CCLE Cell Line Gene CNV Profiles -1.0 -1.36101 T-REx 293 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.594 GSE158182_5_v_7_pnpla3_human RummaGEO Gene Perturbation Signatures 1.0 null central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4426-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE208634_1_v_0_doxycycline_human RummaGEO Drug Perturbation Signatures -1.0 null A172 CCLE Cell Line Gene Expression Profiles -1.0 -1.96612 GTEX-WFJO-1026-SM-3GIKL GTEx Tissue Sample Gene Expression Profiles 1.0 1.51137 H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null UPMD1 DepMap CRISPR Gene Dependency 1.0 2.38303 GSE143994_2_v_1_ythdf1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE88819_1_v_12_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null integral component of endoplasmic reticulum membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE150134_1_v_0_fluorouracil_human RummaGEO Drug Perturbation Signatures -1.0 null Stat2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 88.295 H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05525 GSE198165,GSE198166_6_v_10_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null Central medial nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12427 UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03534 Sarcoma_SARC_TCGA-DX-A48J-01A-21R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 1 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.72658 CHL1DM DepMap CRISPR Gene Dependency 1.0 2.34762 GTEX-OOBJ-1026-SM-3NB2L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33114 H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.22184 PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FED48h_vs_D2FAST48h_968_AR-DE-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null SMC3 ENCODE Transcription Factor Targets 1.0 null GSE230174_0_v_1_glycerol_human RummaGEO Drug Perturbation Signatures -1.0 null Ventromedial hypothalamic nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66586 GTEX-QLQW-0005-SM-2S1RA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.972811 Perturb_6680_KO_SREBF1_SRP255872 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.77161 H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null adrenal gland HPA Tissue Protein Expression Profiles 1.0 1.57736 H3K9ac_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-499a-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.199275 hsa-miR-676 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 JUN::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5769 ventral part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.76763 AtrioventricularNode BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.90697 primary auditory cortex (core)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.88698 GTEX-Q2AG-0008-SM-48U2K GTEx Tissue Sample Gene Expression Profiles 1.0 1.41918 hsa-miR-4739 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EB-3 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -5.77757 ESRRG_Deficiency_GDS2811_637_mouse_Fetal heart - Heterozygous null mutant GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE242083,GSE242098_3_v_4_med1_human RummaGEO Gene Perturbation Signatures 1.0 null MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.50181 GSE128099,GSE128159_1_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null MAX ENCODE Transcription Factor Targets 1.0 null hsa-miR-4491 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09338 GSE109530,GSE109531_2_v_3_hdac3_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-VN-A88M-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.84434 H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BAT3 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.291 JD-44-KF86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.339558 paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.52149 retrotrapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07775 cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.827751 JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cation transport GO Biological Process Annotations 2015 1.0 null GSE100863,GSE100864_3_v_0_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-SNOS-0008-SM-4DM6I GTEx Tissue Sample Gene Expression Profiles 1.0 1.09558 POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ERF::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.4992 SIN3A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE179002_2_v_8_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null monocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.142701 Organelle membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XBED-0726-SM-4GIAR GTEx Tissue Sample Gene Expression Profiles 1.0 1.08918 hsa-miR-4267 TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 HS 695T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.75585 GSE110708_0_v_3_adar_mouse RummaGEO Gene Perturbation Signatures -1.0 null STAT1_01_154 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.62204 posteroventral (inferior) parietal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.44934 Sarcoma_SARC_TCGA-IE-A4EK-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRELID1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88199 GTEX-S4Z8-0526-SM-4AD4T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54636 GSE199899_3_v_0_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE198165,GSE198166_8_v_10_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-PLZ6-1326-SM-3NB24 GTEx Tissue Sample Gene Expression Profiles 1.0 0.846079 GTEX-TKQ1-1226-SM-4GICJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.3401 NAA80 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27074 mediodorsal nucleus of thalamus_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05205 GTEX-WL46-0926-SM-3LK7T GTEx Tissue Sample Gene Expression Profiles -1.0 -0.963831 basal reticular formation of p1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31661 NCIH1355 CCLE Cell Line Gene CNV Profiles -1.0 -1.40473 hsa-miR-4488 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A431-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null integral component of organelle membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE158834_2_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QEL4-1226-SM-447A4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47457 primary motor cortex (area M1, area 4)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.26146 Adipose - Visceral (Omentum) GTEx Tissue Gene Expression Profiles 2023 -1.0 -2.09666 superficial stratum of r7BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57941 NCI-H28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08687 GSE193402_0_v_1_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.24192 RVH421_SKIN CCLE Cell Line Proteomics 1.0 2.22777 endoplasmic reticulum part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 r7 part of rostral ventromedial reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6373 mediodorsal nucleus of thalamus_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.27097 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A1H6-01B-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 3.66935 GTEX-NL3H-0011-R1a-SM-48TDJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7261 GTEX-XQ3S-1726-SM-4BOOD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.880649 GSE242333_0_v_2_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13916 NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.49807 GTEX-X62O-1626-SM-46MW9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.43729 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4343-01A-02R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.951027 M-1 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.04906 HCFC1 ENCODE Transcription Factor Targets 1.0 null GTEX-P78B-0226-SM-3NB1Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.10407 GSE156115_2_v_1_igf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Magnesium transporter InterPro Predicted Protein Domain Annotations 1.0 null UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827595 GSE131887_1_v_2_doxycycline_mouse RummaGEO Drug Perturbation Signatures 1.0 null Micronuclei, Chromosome-Defective CTD Gene-Disease Associations 1.0 1.16766 TBP ENCODE Transcription Factor Targets 1.0 null TFAP4::FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 52.1498 SMAD4 ChEA Transcription Factor Targets 1.0 null GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null early endosome GO Cellular Component Annotations 2025 1.0 null RAD21_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_2_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-4261 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null LOU-NH91 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06317 hsa-miR-4273 TargetScan Predicted Conserved microRNA Targets 1.0 0.075559 GSE239373_0_v_1_mettl3_mouse RummaGEO Gene Perturbation Signatures -1.0 null A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.35955 H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.901633 SW 1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46134 intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 dorsolateral prefrontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.25106 PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-RREB1_mod_RREB1 Rummagene Transcription Factor Associations 2026 1.0 null GSE158834_7_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE208634_1_v_2_doxycycline_human RummaGEO Drug Perturbation Signatures -1.0 null fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.080315 POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null membrane part GO Cellular Component Annotations 2015 1.0 null SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.42381 NCI-H2073 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13939 SNU601 CCLE Cell Line Gene Expression Profiles 1.0 1.73951 GTEX-RUSQ-0226-SM-47JWT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.908277 Posterior parietal association areas, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.498 GSE205630_0_v_1_gmds_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14999 TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XP-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null thyroid_5a HPA Tissue Sample Gene Expression Profiles 1.0 3.16692 SLC16A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16406 GTEX-RWS6-2326-SM-2XCB4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.5766 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mononuclear phagocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.140135 POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-6590-01A-12R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT4 MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-WFON-1726-SM-4LVMQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54137 HCC38_BREAST CCLE Cell Line Proteomics 1.0 6.8206 MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148200_4_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Triangular nucleus of septum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23595 KU812 DepMap CRISPR Gene Dependency 1.0 2.1549 intermediate part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05118 CTCF_pancreas_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE241622_1_v_0_ythdc2_human RummaGEO Gene Perturbation Signatures -1.0 null JD-44-KF86_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.276865 PMC11187533-f1000research-12-166562.nxml-Table_4-GSC_GSC Rummagene Transcription Factor Associations 2026 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2806-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anteromedial visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16151 ARH77 DepMap CRISPR Gene Dependency 1.0 2.28244 GTEX-OHPN-0005-SM-2YUML GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22316 NR1D2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.184 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GR-06A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.48383 GSE198794_0_v_3_usp18_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.831722 COX4I1 Pathway Commons Protein-Protein Interactions 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-5477-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 SPI1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z4-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-UTHO-1826-SM-3GAFE GTEx Tissue Sample Gene Expression Profiles 1.0 1.48354 brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null mantle zone of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28898 Anterior cingulate area, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39872 CHD7 ENCODE Transcription Factor Targets 1.0 null NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.41488 EGFR_drugactivation_30_GDS4361 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.84126 hsa-miR-452 TargetScan Predicted Conserved microRNA Targets 1.0 0.099701 hsa-miR-943 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4421 TargetScan Predicted Conserved microRNA Targets 1.0 0.336728 stratum lacunosum-moleculare of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.990085 H3K4me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Mediodorsal nucleus of thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09997 POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null SMSCTR DepMap CRISPR Gene Dependency 1.0 2.18418 GTEX-WVLH-0006-SM-3MJF7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.961494 Primary somatosensory area, trunk, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07145 POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.973338 SRF_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A4CL-01A-41R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NF-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary auditory cortex (core)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.06943 inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.8584 CTCF_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SEMK2 DepMap CRISPR Gene Dependency 1.0 2.23314 LA-42-ER00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.469256 PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-OLIG2_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_OLIG2 Rummagene Transcription Factor Associations 2026 1.0 null medial superior olive Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19793 GSE48812_4_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null MELK_knockdown_150_GSE32873 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.92783 Parastrial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20216 GSE234043_0_v_1_abcb1_human RummaGEO Gene Perturbation Signatures 1.0 null intrinsic component of organelle membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE140651,GSE140653_2_v_1_med1_human RummaGEO Gene Perturbation Signatures 1.0 null EKVX DepMap CRISPR Gene Dependency 1.0 2.31237 Spleen GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.34252 Lung squamous cell carcinoma_LUSC_TCGA-85-6560-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mediodorsal nucleus of thalamus_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.22737 RUNX2-22187159-PCA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPU-0011-R10A-SM-2XCAH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.955631 GSE126345_7_v_5_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null STAT3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.218 GSE155031_5_v_3_dextran_human RummaGEO Drug Perturbation Signatures -1.0 null PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AOB, internal plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0657 DA-66-OE69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.357465 POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 8458_SSRP1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.31211 CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 1184_CAPRIN1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.556417 MRNIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27819 X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.91973 H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GPM6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80827 medial trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10906 PHB Pathway Commons Protein-Protein Interactions 1.0 null viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056596 YA-92-YO01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.23526 H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC9170756-mmc6.xlsx-P6-Table_S3_The_JUN-targeted_responders_to_FFA_treatments_JUN Rummagene Transcription Factor Associations 2026 1.0 null PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_5_TbID_-biotin_ERM_proteo-Gene_Name_ETV5 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PWOO-2426-SM-2S1OV GTEx Tissue Sample Gene Expression Profiles 1.0 1.32818 PMC9314667-Table_1.xlsx-Regulons-MITF_MITF Rummagene Transcription Factor Associations 2026 1.0 null skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -0.920884 Cells - EBV-transformed lymphocytes GTEx Tissue Gene Expression Profiles 2023 1.0 3.29221 hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.28889 GTEX-XLM4-1526-SM-4AT6D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54061 Main olfactory bulb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07238 ELF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null sin3a_22783022_mcf7_lof_human_gpl570_gds4388 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.193342 urinary system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.08128 SW 1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04574 7754_SEC62_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.601589 protein insertion into ER membrane GO Biological Process Annotations 2023 1.0 null organelle membrane GO Cellular Component Annotations 2015 1.0 null JUND_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AI-0226-SM-48U1D GTEx Tissue Sample Gene Expression Profiles -1.0 -0.893812 GTEX-QV31-1326-SM-2S1QE GTEx Tissue Sample Gene Expression Profiles 1.0 1.34813 ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.23397 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of upper leg skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Q7-1226-SM-4AD5I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42124 CREB1 ChEA Transcription Factor Targets 1.0 null hsa-miR-512-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null JUN-27471255-CHONDROCYTES-MOUSE-RIB ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null golgi apparatus COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GSE179002_2_v_1_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null T3M10 CCLE Cell Line Gene CNV Profiles 1.0 1.46095 GTEX-T6MO-1726-SM-33HB8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.86412 GSE142210_9_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-4694-5p TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 hsa-miR-4420 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 CTCF_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1944 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.828585 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7055-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null brownfat BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.9525 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4994-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YR-11A-13R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2 Rummagene Transcription Factor Associations 2026 1.0 null inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21312 GSE123638,GSE123639_3_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U4B1-0926-SM-4DXUV GTEx Tissue Sample Gene Expression Profiles 1.0 1.18273 protein complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE255680_2_v_0_igf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KE37 DepMap CRISPR Gene Dependency 1.0 2.27213 KDM5A ENCODE Transcription Factor Targets 1.0 null CHD1 ENCODE Transcription Factor Targets 1.0 null POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE136869_1_v_0_lpar2_mouse RummaGEO Gene Perturbation Signatures -1.0 null orbital frontal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.919915 HCC1569 COSMIC Cell Line Gene Mutation Profiles 1.0 null JHU011 DepMap CRISPR Gene Dependency 1.0 2.28849 female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 17555561-Table2 GeneSigDB Published Gene Signatures 1.0 null NCI-H2052 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827595 True leaf TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.545 skin_6a HPA Tissue Sample Gene Expression Profiles -1.0 -0.947244 9962_ZBED2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.60149 outer CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.877571 H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE230329_0_v_3_dextran_mouse RummaGEO Drug Perturbation Signatures 1.0 null CTCF_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-5428-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Endoplasmic reticulum lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.582 CTCF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3428-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mesothelioma_MESO_TCGA-SC-A6LP-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ebolavirus(ZEBOV)_5day_Liver_None_GSE57214 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.07926 GTEX-SNOS-1126-SM-4DM67 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13923 mantle zone of r2Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02007 BICR56 DepMap CRISPR Gene Dependency 1.0 2.29853 H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QEG5-0626-SM-2S1PP GTEx Tissue Sample Gene Expression Profiles 1.0 0.972656 GSE148066,GSE157787_8_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_MCF-7_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.927639 hsa-miR-3919 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 DETROIT562 CCLE Cell Line Gene Expression Profiles 1.0 1.36915 Cerebral cortex TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 G121 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14907 Cerebral hemisphere TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 OB outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31373 primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.3448 GTEX-TSE9-0326-SM-3DB82 GTEx Tissue Sample Gene Expression Profiles 1.0 0.904614 EGR1-20690147-ERYTHROLEUKEMIA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Ventromedial hypothalamic nucleus, dorsomedial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1914 layer 2 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52461 Ventral group of the dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12078 Nerve - Tibial GTEx Tissue Gene Expression Profiles 2023 1.0 1.29921 TAF1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null biological_process GO Biological Process Annotations 2015 1.0 null Sarcoma_SARC_TCGA-IE-A4EI-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null paclitaxel_homo sapiens_gpl570_gse39042 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-4526 TargetScan Predicted Conserved microRNA Targets 1.0 0.205675 hsa-miR-509-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Lung adenocarcinoma_LUAD_TCGA-67-3772-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular organelle GO Cellular Component Annotations 2015 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A6UC-01A-21R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pituitary BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.953065 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q6-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14473 CMTM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05569 Paraflocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01689 GSE214212_2_v_0_chd6_human RummaGEO Gene Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.854399 H3K27ac_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-3792-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.881121 GSE162087_0_v_1_dexamethasone_mouse RummaGEO Drug Perturbation Signatures -1.0 null IKZF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29071 GSE242290_3_v_2_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SE-15-AV21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.37906 Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC8901773-41598_2022_7986_MOESM3_ESM.xls-PIO_vs_LPS-Gene_symbol_ENSEMBL_ID_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PLZ5-0726-SM-2I5F9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.855769 GSE202603_1_v_2_bhlhe40_mouse RummaGEO Gene Perturbation Signatures 1.0 null bounding membrane of organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.002908 GSE84462,GSE84762_0_v_7_ezh2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-P4PQ-0726-SM-3NMCR GTEx Tissue Sample Gene Expression Profiles 1.0 0.957181 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 PMC11630641-mmc8.xlsx-Human_1000cell_NOT_identified-Unnamed_1_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null nd7/23 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.617 hsa-miR-3145-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.541706 macromolecular complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 NKX2-8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7431 CTCF_GM13977_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral group of nuclei, right, ventral division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.980608 HTK CCLE Cell Line Gene Expression Profiles 1.0 1.38544 GTEX-WZTO-0006-SM-3NM9T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58706 Gustatory areas, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01617 stratum lacunosum-moleculare of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22397 CTCF_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 496100639_TCx_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.1361 cingulate gyrus, retrosplenial part, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.14025 H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4729 TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 HCT15 DepMap CRISPR Gene Dependency 1.0 2.18849 MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4XY-0011-R8A-SM-46MVC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50438 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A901-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE211425_1_v_0_mettl3_human RummaGEO Gene Perturbation Signatures 1.0 null PLIN5_OE_GSE44192_482_mouse_heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Perturb_18013_KO_miR18a_SRP050491 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.05249 GTEX-XBEC-1526-SM-4AT68 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05999 shell part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.89584 YY1 ENCODE Transcription Factor Targets 1.0 null CiliaryGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.51783 hsa-miR-4293 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 cetuximab_homo sapiens_gpl570_gse21483 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null COLO 800 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.72317 IZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.865634 GTEX-OXRN-1726-SM-3NM9B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828963 Erythroleukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null superior parietal lobule, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.830752 H3K79me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OIZI-0008-SM-2XCFD GTEx Tissue Sample Gene Expression Profiles 1.0 0.889449 H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null subgranular zone of rostral dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.34509 H4K5ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Thymus Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.0696 EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Vandetanib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0191005 GSE199644_3_v_1_palmitic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null NCIH1436 CCLE Cell Line Gene Expression Profiles 1.0 1.49525 thyroid_5c HPA Tissue Sample Gene Expression Profiles 1.0 1.14181 Lung adenocarcinoma_LUAD_TCGA-38-4631-01A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hematopoietic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054958 AK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04678 Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-3926-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5634 hsa-miR-570 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Appendix BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.0109 SH4 DepMap CRISPR Gene Dependency 1.0 2.33446 hsa-miR-3646 TargetScan Predicted Conserved microRNA Targets 1.0 0.075559 GSE178907_5_v_3_fkrp_human RummaGEO Gene Perturbation Signatures -1.0 null KIF23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33125 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer 1 of AOV cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.97124 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.82996 MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-499-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.199275 hsa-miR-2909 TargetScan Predicted Conserved microRNA Targets 1.0 0.136254 Main olfactory bulb, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22051 occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.964383 GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12874 SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null A-CA-04-2009(H1N1)_36Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -3.60978 Medial habenula Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.0292 H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XLM4-0426-SM-4AT54 GTEx Tissue Sample Gene Expression Profiles 1.0 0.833605 GSE151612_4_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE131887_5_v_2_doxycycline_mouse RummaGEO Drug Perturbation Signatures 1.0 null SALE CCLE Cell Line Gene Expression Profiles 1.0 1.5453 BHLHE40_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMG5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0978 CREM-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Targets 2022 1.0 null medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.938395 GSE184399_0_v_3_cnot1_human RummaGEO Gene Perturbation Signatures -1.0 null CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.22404 primary motor cortex (area M1, area 4)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1845 CTCF_GM20000_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Retrosplenial area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20649 Liver Cirrhosis CTD Gene-Disease Associations 1.0 1.03493 GTEX-RUSQ-2126-SM-47JXK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22011 GSE199644_3_v_2_palmitic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15016 GSE235066_4_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null JUN_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 624 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.67954 Hmx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.9695 PMC12874425-mmc1.xlsx-AT_LPS_vs_AT_SLPS-Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-U8T8-0008-SM-4DXSP GTEx Tissue Sample Gene Expression Profiles 1.0 0.897954 GSE111138,GSE111149_1_v_0_runx3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-PLZ6-0008-SM-48TD5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.880328 GSE111102,GSE111105_3_v_5_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null hematopoietic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056162 GSE235066_4_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE199255,GSE199356_4_v_5_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-3123 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GSE184356_1_v_0_tfam_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OHPN-0011-R4A-SM-2I5FD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11527 POLR2A_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE163297_0_v_2_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null RA-27-ST16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.234456 CEBPA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.9379 Hepatomegaly CTD Gene-Disease Associations 1.0 1.16799 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-8635-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-TKQ2-1826-SM-33HB2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.888307 DMS 273 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.921589 GSE261563_9_v_1_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J2-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LCLC-97TM1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.21997 ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_LNCaP clone FGC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE158320,GSE183351_0_v_1_lin28b_human RummaGEO Gene Perturbation Signatures -1.0 null PML_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7327-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE242290_1_v_2_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null H3K79me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null layer 2 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38533 GTEX-XV7Q-0526-SM-4BRWR GTEx Tissue Sample Gene Expression Profiles 1.0 0.941881 ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-144 TargetScan Predicted Conserved microRNA Targets 1.0 0.205675 HEL9217 DepMap CRISPR Gene Dependency 1.0 2.3689 GSE190950_1_v_0_nono_human RummaGEO Gene Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-CS-4944-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle part GO Cellular Component Annotations 2015 1.0 null NUGC4 CCLE Cell Line Gene CNV Profiles 1.0 1.68152 GTEX-XBED-0926-SM-48TCE GTEx Tissue Sample Gene Expression Profiles 1.0 1.23601 ntera2 HPA Cell Line Gene Expression Profiles -1.0 -0.942315 Temporal lobe TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ATF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null metal ion transport GO Biological Process Annotations 2025 1.0 null POLR2A_K562_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null Phellem TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.91 Ventromedial hypothalamic nucleus, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07214 GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78942 paraterete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16665 GTL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.2236 GSE199189_1_v_0_creld2_mouse RummaGEO Gene Perturbation Signatures 1.0 null LASV_FML29_24hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.852469 GTEX-XMK1-0326-SM-4B652 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.864859 hsa-miR-1256 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10894 PSMG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.69202 SUDHL10 DepMap CRISPR Gene Dependency 1.0 2.01072 GABPA_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE242647_2_v_0_adiponectin_mouse RummaGEO Drug Perturbation Signatures -1.0 null KLF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 120.634 H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null intracellular membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null GSE211128_2_v_1_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null GSE185519_6_v_2_gilteritinib_human RummaGEO Drug Perturbation Signatures -1.0 null dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.893765 GSE226355,GSE226357_1_v_0_ybx1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE168596_2_v_3_adiponectin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE158834_1_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null K562_KW-2449_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0177234 BCOR-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null 11294_NON-TARGETING_NON-TARGETING Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.755753 Primary somatosensory area, trunk, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03726 TEF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.2503 r1 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03659 GSE173578_1_v_0_atf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XOTO-0011-R7B-SM-4B64R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04962 H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null Basimglurant DeepCoverMOA Drug Mechanisms of Action 1.0 0.31 anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.11878 TRIM28 ENCODE Transcription Factor Targets 1.0 null GSE139966_1_v_0_figla_mouse RummaGEO Gene Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YS-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Rhomboid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47535 central nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.870236 membrane GO Cellular Component Annotations 2015 1.0 null spinal (inferior) vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.70241 CTCF_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPM-2126-SM-3LK75 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21622 GSE157894_1_v_3_cystine_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 496100628_FWM_dementia_TBI_77_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.45642 excretory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.072321 JARID1B-DAIN-22020125-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC12375500-41388_2025_3449_MOESM1_ESM.xlsx-DBP_up-gene_DBP Rummagene Transcription Factor Associations 2026 1.0 null testis_7d HPA Tissue Sample Gene Expression Profiles -1.0 -1.81761 YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE242290_1_v_10_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null kidney cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.091663 REH DepMap CRISPR Gene Dependency 1.0 2.35615 Ventral posteromedial nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30938 BMI1 ChEA Transcription Factor Targets 1.0 null 501A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.15979 Limbic system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE140651,GSE140653_2_v_4_med1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE148692,GSE148695_1_v_0_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Endoplasmic reticulum subcompartment COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GSE113005_0_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE210655_1_v_5_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.867594 GTEX-T6MN-0005-SM-32PLJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.96764 hsa-miR-548o TargetScan Predicted Conserved microRNA Targets 1.0 0.181316 EMC complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.599 CTCF_astrocyte of the spinal cord_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Posterolateral visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07845 NRROS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45342 CTCF_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBTF ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-46-3766-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CAOV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34396 CTCF_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Color blindness DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.23 Lung squamous cell carcinoma_LUSC_TCGA-77-7335-11A-01R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral group of nuclei, right, dorsal division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.91246 CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Intrinsic component of endoplasmic reticulum membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.876 H3K4me1_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-PW2O-0826-SM-48TC5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.943782 YY1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MAX_WT_TESTES_MAX Rummagene Transcription Factor Associations 2026 1.0 null YY1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-1626-SM-3LK5F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.928513 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null layer 1 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52461 NDUFB10 Pathway Commons Protein-Protein Interactions 1.0 null POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE173232_1_v_3_sf3b1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.17661 EBF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.1274 H3K9ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null REST_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.5364 HCC4006 CCLE Cell Line Gene Expression Profiles 1.0 1.65939 GSE228181_3_v_1_idh1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ion transport GO Biological Process Annotations 2015 1.0 null PRDX4 Pathway Commons Protein-Protein Interactions 1.0 null liver HPA Tissue Gene Expression Profiles -1.0 -1.41027 Lung squamous cell carcinoma_LUSC_TCGA-66-2778-01A-02R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE136742,GSE136744_2_v_3_setd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE125153_1_v_3_bcl3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE198165,GSE198166_7_v_11_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPK5-0126-SM-3GADM GTEx Tissue Sample Gene Expression Profiles 1.0 0.886099 anterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.839466 Arcuate hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33479 NCIH841 CCLE Cell Line Gene CNV Profiles -1.0 -1.80058 PMC9932992-mmc7.xlsx-S6D-Table_S6D_Per-gene_per-sample_AR_data_LCLs_AR Rummagene Transcription Factor Associations 2026 1.0 null Primary somatosensory area, upper limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13964 MZ in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0676 PSMB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41425 A172 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.56551 KLF10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 127.688 hsa-miR-520c-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GSE158834_7_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Digestive cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.656 ATF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.84323 GTEX-NFK9-1626-SM-3LK5J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.911187 NCIH2172 CCLE Cell Line Gene CNV Profiles -1.0 -2.09248 GTEX-QLQW-0226-SM-447BJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.88581 GSE213650_3_v_2_everolimus_human RummaGEO Drug Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4133-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-POYW-0426-SM-2XCEV GTEx Tissue Sample Gene Expression Profiles 1.0 1.23126 H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LCLC-97TM1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.852404 GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -3.34348 H3K4me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Cerebral lobe TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HU-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inner CP in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04377 ventral pallium Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21216 CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H2-01A-12R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.39857 H3K4me3_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Wing disc TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.819 M14 cell ProteomicsDB Cell Type and Tissue Protein Expression Profiles 1.0 0.942673 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A114-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lateral habenula Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13118 CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null G124 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.869829 Ameloblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.749 CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null temporal lobe TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ATF3 ENCODE Transcription Factor Targets 1.0 null CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RN64-1026-SM-48FDX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01279 rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.618714 ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 layer III of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.838983 H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-1183 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 adult stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.085225 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3433-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RU72-1226-SM-2TF6N GTEx Tissue Sample Gene Expression Profiles 1.0 1.73197 H3K27me3_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B2-3923-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.84985 Ventral pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.901259 SARS-BatSRBD_Day1_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.87688 H3K4me1_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SF3B6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25856 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F4_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XXEK-0726-SM-4BRWF GTEx Tissue Sample Gene Expression Profiles 1.0 0.873736 RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_14918_KD_SF3B1_SRP316095 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 9.65665 lateral parabrachial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.847579 endometrium_8b HPA Tissue Sample Gene Expression Profiles 1.0 0.926112 GSE216043_3_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null SETDB1 ENCODE Transcription Factor Targets 1.0 null Field CA2, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02413 GSE110708_1_v_3_adar_mouse RummaGEO Gene Perturbation Signatures -1.0 null supraoptic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18274 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JRA - Juvenile rheumatoid arthritis_Peripheral blood mononuclear cell_GSE7753 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.4054 GTEX-OOBK-0008-SM-3NB27 GTEx Tissue Sample Gene Expression Profiles 1.0 1.15452 parasolitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.71403 BMI1-19503595-MEFC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZM-1626-SM-4DXSK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23183 CTCF_MEL cell line_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectal Mucosa Donor 31 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.923959 H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE116810_5_v_4_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null GSE213611_1_v_0_nuf2_human RummaGEO Gene Perturbation Signatures -1.0 null preoptic region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.17752 H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NOP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28476 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4834-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE111385_0_v_3_tgfbr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-Q3-AA2A-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-S7SE-0326-SM-4AT5Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31328 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.972021 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4117-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QESD-2026-SM-447BI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.65905 hsa-miR-4295 TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 PMC12079334-ADVS-12-2501734-s002.pdf-89-ENSG00000186376_ZNF75D Rummagene Transcription Factor Associations 2026 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5527-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null P32-ISH Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.56224 H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CCND1 ChEA Transcription Factor Targets 1.0 null POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.13272 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149903_5_v_7_myd88_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE116810_5_v_3_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null golgi membrane GO Cellular Component Annotations 2015 1.0 null pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Perturb_2798_KD_TRPS1_SRP125141 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -15.5614 PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-human_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.880668 GSE146074_1_v_8_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null IZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.3961 GTEX-OXRO-1926-SM-2S1O3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.113 GTEX-TSE9-0011-R9A-SM-3DB7Q GTEx Tissue Sample Gene Expression Profiles -1.0 -0.861811 YY1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ECHS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21751 GSE214596,GSE214598_1_v_0_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null Perturb_12317_KD_HNRNPM_SRP136770 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.84296 GTEX-P4PQ-1726-SM-3NB15 GTEx Tissue Sample Gene Expression Profiles 1.0 0.876542 NCI-H292 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.91845 Primary somatosensory area, mouth, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08693 PSMA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09234 H3K27me3_erythroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054709 posteroventral (inferior) parietal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.8514 HOXD12::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7731 amygdaloid complex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.17831 GSE93309_2_v_0_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XOTO-0011-R9A-SM-4GICI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.850635 GTEX-OIZH-2126-SM-3NB1P GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886008 C3A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.48998 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null H3K4me3_CD34 Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.71038 POLR2A_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2218_BREAST CCLE Cell Line Proteomics 1.0 2.37238 Integral component of organelle membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.773 Anterolateral visual area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70789 OCI-M1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.98972 GSE226285_3_v_0_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null SCARB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09154 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4985-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE133087_5_v_0_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041496 dorsomedial preoptic area, superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.20793 Subparafascicular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08693 GSE203308_8_v_3_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE158834_2_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null ATF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.2141 CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4959-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MOLM13 DepMap CRISPR Gene Dependency 1.0 2.12622 Primary somatosensory area, trunk, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06805 Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GW-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE227592_9_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null GSE207582_2_v_1_testosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null NCI-H650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34923 Paraventricular nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35864 GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25466 CTCF_mammary epithelial cell_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBX3 ENCODE Transcription Factor Targets 1.0 null Trypanosomoid cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.883 BRD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37994 TFAP4::ETV1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.3998 CTCF_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETV2::HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.468 GSE169617_1_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2J2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25686 POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCYL1_knockdown_194_GSE57646 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.12838 glia TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.217554 CAKI2_KIDNEY CCLE Cell Line Proteomics 1.0 2.54494 4578_LIG1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.668083 GTEX-NL3H-0011-R2a-SM-2I3GG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.83715 hippocampus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE239844_7_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null KLM1 CCLE Cell Line Gene Expression Profiles 1.0 2.27339 PAX2 JASPAR Predicted Transcription Factor Targets 1.0 null POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SHI1 DepMap CRISPR Gene Dependency 1.0 2.30433 MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2434 GSE98898_4_v_1_hoxa1_human RummaGEO Gene Perturbation Signatures -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13J-11A-13R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null magnesium ion transmembrane transporter activity GO Molecular Function Annotations 2025 1.0 null THP1 DepMap CRISPR Gene Dependency 1.0 2.3924 lateral septal nucleus, intermediate part, periventricular Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2906 SIX5 ENCODE Transcription Factor Targets 1.0 null HDAC2_Deficiency_GDS2624_658_mouse_Embryonic heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null SARS-CoV MA15_Day2-PFU-10^4_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.90458 Primary somatosensory area, nose, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 4.44139 H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QEG4-0126-SM-48TZE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.80421 ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE168596_1_v_3_adiponectin_mouse RummaGEO Drug Perturbation Signatures 1.0 null ZNF257 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 52.7546 IZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26007 anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.15136 HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.46474 GTEX-OOBK-2126-SM-3LK5T GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05453 GSE246461,GSE246463_5_v_0_mecp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H1 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.46857 GTEX-SUCS-1326-SM-4DM5T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05692 KDM5B ENCODE Transcription Factor Targets 1.0 null Anchored component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.61 ETS1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DLAT Pathway Commons Protein-Protein Interactions 1.0 null JARID1A-20064375-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null MZ in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.30708 CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCND1-20090754-RETINA-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.33018 REST_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null transporter activity GO Molecular Function Annotations 2015 1.0 null RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bed nucleus of the anterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66586 OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.22975 head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053691 endoplasmic reticulum membrane GO Cellular Component Annotations 2025 1.0 null Urofacial syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.077 ZBTB7A ENCODE Transcription Factor Targets 1.0 null GSE214596,GSE214598_1_v_2_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K36me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.925843 H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3365-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Main olfactory bulb, mitral layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12773 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QLQW-0326-SM-447A8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04007 GSE87404,GSE87812_1_v_0_hoxa9_mouse RummaGEO Gene Perturbation Signatures 1.0 null OB granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05641 SARS-BatSRBD_72Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.99292 GSE81193_3_v_2_irf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Endoplasmic reticulum membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.917 GSE148262,GSE150691_1_v_2_hdlbp_human RummaGEO Gene Perturbation Signatures -1.0 null H3K79me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UTHO-2426-SM-4JBHD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.887307 LMAN2 Pathway Commons Protein-Protein Interactions 1.0 null GSE222758_0_v_1_clofazimine_human RummaGEO Drug Perturbation Signatures 1.0 null 496100605_TCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.06605 YY1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBED-2026-SM-4AT5D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03526 hsa-miR-381 TargetScan Predicted Conserved microRNA Targets 1.0 0.127531 Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUO-01A-12R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GABPA_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHSE-0011-R7A-SM-3P5YZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828627 PANC 05.04 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.890461 JUN_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PL-21 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.21228 Perturb_11655_KD_MCFP_SRP113334 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.59501 hsa-miR-4252 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBJ-3026-SM-3NB1D GTEx Tissue Sample Gene Expression Profiles 1.0 1.33911 HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.7965 SPIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.4925 uterine cervix TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE147662_2_v_4_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE136742,GSE136744_0_v_3_setd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ATF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.9097 18362358-Table7 GeneSigDB Published Gene Signatures 1.0 null H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BT-549 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.04156 GSE201042_2_v_4_ptpmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QVUS-0011-R8A-SM-3GAD7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.34221 mediodorsal nucleus of thalamus_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.32154 CTCF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NUGC-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.0003 TIMELESS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18408 CTCF_kidney_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RUSQ-0426-SM-47JWR GTEx Tissue Sample Gene Expression Profiles 1.0 1.26842 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.14763 NELFE_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE77108_5_v_1_saha_human RummaGEO Drug Perturbation Signatures 1.0 null substrate-specific transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null ERF::FOXO1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.3844 FOXM1_01_77 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.64224 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.36833 Uterine Carcinosarcoma_UCS_TCGA-N6-A4V9-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 8653_TAF12_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.59809 RAD21 ENCODE Transcription Factor Targets 1.0 null VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.42392 GTEX-P4QS-2126-SM-3NMCF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28097 ZNF597 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07513 GSE147662_0_v_1_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null reticular formation of p1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.90998 EF-74-KW12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.366045 Entorhinal area, lateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12083 golgi apparatus GO Cellular Component Annotations 2015 1.0 null MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20162 Perturb_559_OE_NUP98HOXA10_SRP158432 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.61133 NCO2 DepMap CRISPR Gene Dependency 1.0 2.39958 HMGN3 ENCODE Transcription Factor Targets 1.0 null IRF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE179002_4_v_7_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05249 Medial pretectal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72661 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5970-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PML_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Anterolateral visual area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.33855 GSE227592_6_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null cingulate gyrus, retrosplenial part, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.06905 ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null GTEX-V1D1-1926-SM-4JBGX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.941212 PMC9170756-mmc6.xlsx-all_differential_proteins-Table_S3_The_JUN-targeted_responders_to_FFA_treatments_JUN Rummagene Transcription Factor Associations 2026 1.0 null NCI-H1975 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827595 hsa-miR-323b-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.17031 GSE158834_2_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE231641_0_v_1_robo1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MM-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE214596,GSE214598_1_v_4_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null phagocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.122616 H4K91ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 CTCF_astrocyte of the spinal cord_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR1 ChEA Transcription Factor Targets 1.0 null Nuclear outer membrane-endoplasmic reticulum membrane network COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142210_9_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE158834_7_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null organelle membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 MICAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76119 GTEX-QV44-2226-SM-447A3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.3196 Interanteromedial nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28222 H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BT-20 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.08115 NR2F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6715 H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7468-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X5EB-2626-SM-4E3HZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.44101 Perturb_2846_KD_YAP1/WWTR1_SRP201886 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE102505_6_v_0_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55D-1426-SM-48FEN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10067 H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RPMI7951 CCLE Cell Line Gene CNV Profiles -1.0 -1.36592 hsa-miR-494 TargetScan Predicted Conserved microRNA Targets 1.0 0.598666 PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3 Rummagene Transcription Factor Associations 2026 1.0 null SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE228430_1_v_3_fabp5_human RummaGEO Gene Perturbation Signatures 1.0 null 496100324_FWM_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.08359 NANOG-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P78B-0726-SM-2S1O2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.93037 GTEX-R55C-1826-SM-3GADI GTEx Tissue Sample Gene Expression Profiles 1.0 1.7638 WSUNHL DepMap CRISPR Gene Dependency 1.0 2.34141 HS 69ST Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.70363 primary auditory cortex (core)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.864426 SNU719 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 ZMIZ1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LSM11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55651 GSE158815_1_v_3_trib1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SAP30 ENCODE Transcription Factor Targets 1.0 null GTEX-X5EB-2026-SM-4E3KA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.8147 GSE157904_3_v_1_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Flp-In-T-REx cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.314 Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T6-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 ATF3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100595_PCx_probable Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.61204 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-3119 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 4107_IMP3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.65295 IRF1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null HPAC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.828336 ZNF883 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02028 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NA-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XYKS-0926-SM-4BRVG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03646 ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.929075 PMC12816669-41698_2025_1236_MOESM1_ESM.pdf-1145-ATF6B_ATF6B Rummagene Transcription Factor Associations 2026 1.0 null MXI1 ENCODE Transcription Factor Targets 1.0 null hsa-miR-524-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.131849 RKO DepMap CRISPR Gene Dependency 1.0 2.07059 POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1143 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.03668 layer 3 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10143 GSE87404,GSE87812_2_v_3_hoxa9_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-UTHO-1026-SM-3GAF7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.46111 GTEX-RVPU-0011-R7A-SM-2XCAB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46301 Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Imaginal disc TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.818 GTEX-P4PQ-0426-SM-3NMCI GTEx Tissue Sample Gene Expression Profiles 1.0 0.965939 hsa-miR-4438 TargetScan Predicted Conserved microRNA Targets 1.0 0.49473 ncoa_22072566_ly2_lof_human_gpl570_gds4095 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.163167 LHB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18455 GSE179002_4_v_6_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE147662_2_v_5_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null STAT4 ChEA Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29Q-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.47568 Thyroid BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.30136 MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1 ENCODE Transcription Factor Targets 1.0 null mantle zone of AOV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.60368 Extrinsic component of external side of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.198 Brain Lower Grade Glioma_LGG_TCGA-VM-A8CF-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PLSCR1 Pathway Commons Protein-Protein Interactions 1.0 null H3K79me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PANC 02.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20162 early endosome COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Bach1::Mafk JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.6228 brain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056695 Anterolateral visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.0659 GSE211128_3_v_5_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.222 KCL-22 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.42568 P3HR1 CCLE Cell Line Gene Expression Profiles -1.0 -1.46816 H3K27me3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM10248_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8528285-pbio.3001085.s010.xlsx-Fig_S7B-GENE_LIST_UPLOADED_TO_ENRICHR_MAX_WT_TESTES_874_GENES_MAX Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SIK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52137 CTCF_MCF-7_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.32161 H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPK5-1426-SM-4JBHH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.85748 superficial stratum of AOV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.60485 PBX3 ENCODE Transcription Factor Targets 1.0 null H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 20937356-TableS2 GeneSigDB Published Gene Signatures 1.0 null GTEX-OXRK-0526-SM-3NB2F GTEx Tissue Sample Gene Expression Profiles 1.0 1.69069 GSE198165,GSE198166_0_v_1_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE168697_0_v_1_wdr6_mouse RummaGEO Gene Perturbation Signatures -1.0 null liver_d HPA Tissue Sample Gene Expression Profiles -1.0 -0.96206 cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.1275 GSE192513,GSE192515_1_v_0_atg16l1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RU1J-1926-SM-2TF6S GTEx Tissue Sample Gene Expression Profiles 1.0 0.881846 ovary HPA Tissue Protein Expression Profiles -1.0 -1.1008 H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HB-06-WU12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.234921 AHDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18035 CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1323 TargetScan Predicted Conserved microRNA Targets 1.0 0.181316 18081427-TableS7 GeneSigDB Published Gene Signatures 1.0 null Early endosome COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 POLR3K CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53144 MCF7_MC1568_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0170411 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null EB1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.08832 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.31924 H3K56ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-4766-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 PXMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09877 macromolecular complex GO Cellular Component Annotations 2015 1.0 null NCIH1651 CCLE Cell Line Gene CNV Profiles -1.0 -1.362 GTEX-T5JC-0005-SM-4DM7B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20939 JMSU1 CCLE Cell Line Gene CNV Profiles 1.0 1.36113 smooth muscle HPA Tissue Protein Expression Profiles -1.0 -1.1008 GABPA_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEPG2 CCLE Cell Line Gene Expression Profiles -1.0 -1.4596 ABAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05393 KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary somatosensory area, unassigned, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.80723 magnesium ion transport GO Biological Process Annotations 2023 1.0 null Lung GTEx Tissue Gene Expression Profiles 2023 1.0 0.832489 Dentate gyrus, granule cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02073 medial tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38719 er membrane protein complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55C-1426-SM-48FED GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15758 Lung squamous cell carcinoma_LUSC_TCGA-43-5670-01A-21R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10788 membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 hsa-miR-944 TargetScan Predicted Conserved microRNA Targets 1.0 0.111118 GSE184356_1_v_2_tfam_human RummaGEO Gene Perturbation Signatures -1.0 null GSE210682_2_v_3_methadone_human RummaGEO Drug Perturbation Signatures 1.0 null BHLHE40 ENCODE Transcription Factor Targets 1.0 null POLR2AphosphoS2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF506 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4353 GSE210476_2_v_0_rutaecarpine_human RummaGEO Drug Perturbation Signatures -1.0 null OAW28 CCLE Cell Line Gene CNV Profiles 1.0 1.45828 Medial geniculate complex, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21221 H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GP5D COSMIC Cell Line Gene Mutation Profiles 1.0 null POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YT-0226-SM-32PK5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21289 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null SP2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 136.49 SUP-B8 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.71213 HT-55 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.970428 hsa-miR-410 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GSE151090_0_v_4_verteporfin_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.42452 GTEX-NPJ7-1326-SM-3MJHO GTEx Tissue Sample Gene Expression Profiles 1.0 2.25084 H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H4K20me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S4UY-0426-SM-3K2AF GTEx Tissue Sample Gene Expression Profiles 1.0 1.13771 H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null 7504_RPS15_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.79331 hsa-miR-1283 TargetScan Predicted Conserved microRNA Targets 1.0 0.031759 anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06591 MAZ ENCODE Transcription Factor Targets 1.0 null PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_4_Overlap_of_ERM_proteom-Gene_Name_ETV5 Rummagene Transcription Factor Associations 2026 1.0 null Gata3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.7023 Retinal rod TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.72 RAD21_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Fatty Liver CTD Gene-Disease Associations 1.0 1.28703 GTEX-RTLS-1326-SM-46MUN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66479 smoothmuscle_8b HPA Tissue Sample Gene Expression Profiles 1.0 1.26185 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17624 H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143 ENCODE Transcription Factor Targets 1.0 null GTEX-RM2N-1926-SM-48FCU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22187 OCUM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.29669 intermediate stratum of p1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.91136 hsa-miR-301a TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 pancreas_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.0341 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RMSYM DepMap CRISPR Gene Dependency 1.0 2.18356 GSE160817_5_v_1_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null prepositus hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01131 MDA-MB-453 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20898 ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.844092 GTEX-Q734-0326-SM-48U15 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37521 Hyperplasia CTD Gene-Disease Associations 1.0 1.31746 GTEX-PWCY-0008-SM-48TE9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.872014 H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE113106_2_v_1_dnm2_mouse RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of r2Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.12075 GTEX-R55E-0726-SM-48FCZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.37446 Midline group of the dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08626 GTEX-XQ8I-1926-SM-4BOOK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29392 periventricular stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01822 CTCF_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE164884_2_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null Mesothelioma_MESO_TCGA-MQ-A6BR-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_Rectal Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Geniculate group, dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70318 GTEX-REY6-1226-SM-48FDR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20191 ZNF233 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37394 HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.29578 mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.846699 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 BEN CCLE Cell Line Gene CNV Profiles 1.0 1.64789 Cco TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.742 dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.75368 TCF7L2 ENCODE Transcription Factor Targets 1.0 null Dorsal part of the lateral geniculate complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72124 Vagina GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.546038 intracellular organelle LOCATE Curated Protein Localization Annotations 1.0 null blood TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null r7 part of the dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01822 NANOG-18347094-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null PMC5670203-41467_2017_1251_MOESM5_ESM.xlsx-differential_expressed_BCL6_tar-ensembl_gene_id_BCL6 Rummagene Transcription Factor Associations 2026 1.0 null ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE245270_1_v_4_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE214212_2_v_1_chd6_human RummaGEO Gene Perturbation Signatures 1.0 null KAT2A ENCODE Transcription Factor Targets 1.0 null GTEX-S7PM-0008-SM-3NM9Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.32845 H3K27me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null blood vessel GTEx Tissue Gene Expression Profiles 1.0 1.67086 Brain Lower Grade Glioma_LGG_TCGA-IK-7675-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null outer SZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03243 Perturb_8728_KD_ZNF414_SRP269946 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Nkx3-2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.7125 cerebellar cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.75103 GTEX-P4QS-0726-SM-3NMCZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.01268 GSE224969,GSE224971_3_v_5_chtop_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-TSE9-0426-SM-3DB81 GTEx Tissue Sample Gene Expression Profiles 1.0 2.7146 primary auditory cortex (core)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.842353 H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null SG in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.13938 tuberomammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.998805 GTEX-X4XY-0526-SM-46MW1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.898965 CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.44801 Lung adenocarcinoma_LUAD_TCGA-78-7535-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE210655_3_v_0_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-1178 TargetScan Predicted Conserved microRNA Targets 1.0 0.766596 H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_5968_KD_SUV39H1_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.8662 SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04921 ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.3315 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null breast HPA Tissue Protein Expression Profiles -1.0 -1.1008 Brain Lower Grade Glioma_LGG_TCGA-VW-A8FI-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-FC-A5OB-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COX6B1 Pathway Commons Protein-Protein Interactions 1.0 null NR1D1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.0011 Brain Lower Grade Glioma_LGG_TCGA-FG-A4MX-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null JD-44-KF86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.433457 CTCF_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A194-01A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-TSE9-0726-SM-3DB8C GTEx Tissue Sample Gene Expression Profiles 1.0 0.824872 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial group of nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.879612 r3 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01886 Intrinsic component of endoplasmic reticulum membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 NCIH1651 CCLE Cell Line Gene Expression Profiles -1.0 -2.68779 GSE158834_2_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null superficial stratum of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.69568 Heart - Left Ventricle GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.06321 GTEX-QDVN-0126-SM-4GIC9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.964637 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4074-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FW-A5DX-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE248045,GSE248046_0_v_2_runx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE112174_5_v_7_runx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EA-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE223008_6_v_12_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null STOML2 Pathway Commons Protein-Protein Interactions 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UH-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CCK-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null 496100604_HIP_no dementia_TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.82619 BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE77108_3_v_1_saha_human RummaGEO Drug Perturbation Signatures 1.0 null GSE221327_8_v_9_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null E2F1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null KON DepMap CRISPR Gene Dependency 1.0 2.02515 H3K4me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GOLT1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24781 SRF ENCODE Transcription Factor Targets 1.0 null layer VI of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.939227 CTCF_GM12869_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POYW-0006-SM-2XCF4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.974505 DMS114 CCLE Cell Line Gene CNV Profiles -1.0 -1.48363 GSE203655_0_v_1_stat1_mouse RummaGEO Gene Perturbation Signatures 1.0 null JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21843 POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF1 ENCODE Transcription Factor Targets 1.0 null PMC8065135-41467_2021_22068_MOESM6_ESM.xlsx-E_MYOG_binding_in_downreg-Unnamed_1_MYOG Rummagene Transcription Factor Associations 2026 1.0 null 10549_ZNF681_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.505498 GTEX-XV7Q-0626-SM-4BRV5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.962801 POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Oligosaccharyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.667 GTEX-XLM4-0005-SM-4AT4P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00873 GSE189859,GSE189861_0_v_2_idh1_human RummaGEO Gene Perturbation Signatures -1.0 null EFO-21 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.96874 hsa-miR-3150a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 lateral tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38161 H3K27ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null endomembrane system COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Prostate adenocarcinoma_PRAD_TCGA-G9-6362-11A-01R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null SP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 138.962 EMC complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW1990 COSMIC Cell Line Gene Mutation Profiles 1.0 null BHK cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.92 GTEX-U8T8-1126-SM-4DXUE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60841 GTEX-RTLS-0008-SM-48FET GTEx Tissue Sample Gene Expression Profiles 1.0 1.11564 Lung squamous cell carcinoma_LUSC_TCGA-56-A4BX-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null anterior olfactory area, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.60603 POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.08731 GSE127790_4_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-PLZ5-0826-SM-3P5ZW GTEx Tissue Sample Gene Expression Profiles 1.0 0.877337 DU-4475 COSMIC Cell Line Gene Mutation Profiles 1.0 null POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ensembl_LTF Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null 6632_PPIL4_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.536138 GTEX-Q2AH-2026-SM-2S1PX GTEx Tissue Sample Gene Expression Profiles 1.0 1.07083 GSE110268_0_v_3_foxd1_human RummaGEO Gene Perturbation Signatures 1.0 null mantle zone of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.76489 inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.17395 GSE114232_10_v_11_mavs_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZC3H11A ENCODE Transcription Factor Targets 1.0 null GSE118077_1_v_8_sprr5_human RummaGEO Gene Perturbation Signatures -1.0 null GSE142210_2_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null MN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45641 GSE130956_2_v_1_icaritin_human RummaGEO Drug Perturbation Signatures 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2987-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A8SP-01B-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DHX15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28372 SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR1 ENCODE Transcription Factor Targets 1.0 null OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.92775 zfx_17448993_embryonic_stem_cell_lof_mouse_gpl1261_gds2718 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.078846 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LT-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Inflammation CTD Gene-Disease Associations 1.0 1.35328 GSE183251_1_v_3_cyp2c70_mouse RummaGEO Gene Perturbation Signatures 1.0 null MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mitochondrial crista junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.616 H4K5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A5SK-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48338 Brain - Cerebellum GTEx Tissue Gene Expression Profiles 2023 1.0 1.80196 RFX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null u2197 HPA Cell Line Gene Expression Profiles 1.0 0.92903 Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A67A-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null JUND ENCODE Transcription Factor Targets 1.0 null amygdaloid complex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.900031 PMC8528285-pbio.3001085.s010.xlsx-Fig_7E-MAX_WT_TESTES_MAX Rummagene Transcription Factor Associations 2026 1.0 null GTEX-VUSG-0526-SM-4KL22 GTEx Tissue Sample Gene Expression Profiles 1.0 1.186 GTEX-S32W-1126-SM-4AD5V GTEx Tissue Sample Gene Expression Profiles 1.0 0.916136 HCC202 CCLE Cell Line Gene Expression Profiles -1.0 -2.12345 RERFGC1B CCLE Cell Line Gene Expression Profiles -1.0 -2.42194 GSE57871_5_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XOT4-0005-SM-4B64S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29063 GSE186440,GSE186443_2_v_5_daxx_human RummaGEO Gene Perturbation Signatures 1.0 null GSE151689_0_v_1_panobinostat_mouse RummaGEO Drug Perturbation Signatures -1.0 null K562_Ellagic acid_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.016164 striatum_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.18452 STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CTCF_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37752 SP in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.888224 hsa-miR-19b TargetScan Predicted Conserved microRNA Targets 1.0 0.454769 inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.54348 hsa-miR-142-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.293524 GTEX-PX3G-0826-SM-48TZS GTEx Tissue Sample Gene Expression Profiles -1.0 -2.03712 POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 1464_CDYL_P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.00825 SCC4 CCLE Cell Line Gene CNV Profiles 1.0 1.40183 H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_cerebellum_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE179002_0_v_7_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZFP57 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.8433 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.312 thyroid_5d HPA Tissue Sample Gene Expression Profiles 1.0 1.76678 Primary somatosensory area, trunk Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10348 hsa-miR-4669 TargetScan Predicted Conserved microRNA Targets 1.0 0.517189 GTEX-O5YV-1626-SM-2YUNJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.72878 NR3C1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-Genes_with_ATF3_combined_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null SERINC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09594 GSE190555,GSE190557_2_v_0_chd4_human RummaGEO Gene Perturbation Signatures -1.0 null bonemarrow BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.960618 NCIH650 CCLE Cell Line Gene Expression Profiles 1.0 1.69085 POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Epithalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41899 early endosome GO Cellular Component Annotations 2015 1.0 null Hand1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.3701 Endoplasmic reticulum subcompartment COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.915 Dhori Virus_48Hour_20090954_GSE17400 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.1744 STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RH28 DepMap CRISPR Gene Dependency 1.0 2.33234 POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U8XE-1026-SM-4E3HM GTEx Tissue Sample Gene Expression Profiles 1.0 1.08055 primary auditory cortex (core)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16829 TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-CA-04-2009(H1N1)_Day3_22532695_GSE36328 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.72354 Perturb_6678_KO_PMVK_SRP255872 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.52969 glial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.220378 tail-anchored membrane protein insertion into ER membrane GO Biological Process Annotations 2023 1.0 null ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.890754 YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null endometrium_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.12668 CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE125782_3_v_2_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null ARID3A ENCODE Transcription Factor Targets 1.0 null GTEX-RN64-0526-SM-2TC5P GTEx Tissue Sample Gene Expression Profiles 1.0 1.03911 ER membrane insertion complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.524 HDAC6 ENCODE Transcription Factor Targets 1.0 null NCIH1339 CCLE Cell Line Gene Expression Profiles 1.0 1.50149 H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPN-0011-R1A-SM-2I5GB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34477 ERF::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.9229 496100575_PCx_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.19522 KE39 CCLE Cell Line Gene CNV Profiles 1.0 1.51801 CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE96991,GSE97117_5_v_2_il11_mouse RummaGEO Gene Perturbation Signatures 1.0 null posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.903549 cv-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.210961 ELK1 ENCODE Transcription Factor Targets 1.0 null CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null OCIMY7 DepMap CRISPR Gene Dependency 1.0 2.31877 Blood cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-WYBS-0426-SM-3NM9M GTEx Tissue Sample Gene Expression Profiles 1.0 1.23435 agranular insular cortex (area Iag) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27897 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MM1S DepMap CRISPR Gene Dependency 1.0 2.04652 Rough endoplasmic reticulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.671 H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QEL4-0526-SM-3GIJ4 GTEx Tissue Sample Gene Expression Profiles 1.0 2.56289 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR2F2 ENCODE Transcription Factor Targets 1.0 null GSE159049_3_v_0_sox2_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A5UE-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW1573 CCLE Cell Line Gene CNV Profiles -1.0 -2.23778 sirolimus_mus musculus_gpl1261_gse21755 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null orbital frontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.70194 yy1_20215434_hela_lof_human_gpl570_gds3788 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.604988 GTEX-N7MS-0426-SM-2YUN6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02153 GSE200352_11_v_6_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null TAF1_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE209938_0_v_1_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null 10400_ZNF497_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.21779 CREB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U4B1-1226-SM-4DXT7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.866962 Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6826-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE223008_5_v_3_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null lateral mammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.90999 OCIMY7 CCLE Cell Line Gene CNV Profiles -1.0 -1.63171 H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ventrolateral prefrontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.994117 TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QVJO-0011-R6A-SM-2S1QN GTEx Tissue Sample Gene Expression Profiles 1.0 1.16284 GSE114013,GSE114014_1_v_4_itraconazole_human RummaGEO Drug Perturbation Signatures 1.0 null JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.3535 periventricular stratum of PalSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28981 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-453 cell ProteomicsDB Cell Type and Tissue Protein Expression Profiles 1.0 2.18809 H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PW2O-1926-SM-2S1OB GTEx Tissue Sample Gene Expression Profiles 1.0 2.07869 GSE48812_4_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7437-01A-21R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null membrane region COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.008503 OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.19985 KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.10158 anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.25879 GSE211989_0_v_1_nlrc3_mouse RummaGEO Gene Perturbation Signatures -1.0 null IRF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.2615 H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Lateral dorsal nucleus of thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06669 SP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 127.703 magnesium ion transport GO Biological Process Annotations 2015 1.0 null H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null uterus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null decitabine_homo sapiens_gpl570_gse30985 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-33-4533-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Retrochiasmatic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07685 SCID - Severe combined immunodeficiency_Lung Tissue_GSE3414 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.73186 CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-5095 TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BACH1 ENCODE Transcription Factor Targets 1.0 null cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE111247_2_v_13_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.952421 H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2805-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null E2F1-26619117-HEPATOCYTES-MOUSE-LIVER ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-DY-A1H8-01A-21R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null inorganic cation transmembrane transporter activity GO Molecular Function Annotations 2023 1.0 null CREB1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebral hemisphere TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null hsa-miR-514b-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.436802 HOP-62 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.65532 PPIF_KO_GSE23028_45_mouse_heart (8 wk) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null leukocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059377 H4K20me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52101 GSE198165,GSE198166_6_v_11_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null gf95 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.476 mantle zone of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36804 H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OHPN-0011-R11A-SM-2I5FM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08469 GTEX-XUJ4-0126-SM-4BOP7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.850768 Stratum intermedium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.525 H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NTRK2_drugactivation_66_GSE20358 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.36498 GSE142684_3_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OOBJ-0826-SM-3NB2K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47426 GTEX-U3ZH-1526-SM-4DXV1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05759 Nuclear outer membrane-endoplasmic reticulum membrane network COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.914 NCIH1734 CCLE Cell Line Gene CNV Profiles 1.0 1.32836 WRNIP1 ENCODE Transcription Factor Targets 1.0 null SP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.63186 NKX2-3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.9559 OCIAD2 Pathway Commons Protein-Protein Interactions 1.0 null KDM1A ENCODE Transcription Factor Targets 1.0 null A-498 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.840377 SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.955689 C170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null hsa-miR-519c-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GSE182680,GSE182683_7_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null GSE120370_4_v_3_thrombin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Hippocampus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.71601 GSE249098_1_v_0_mthfd1l_human RummaGEO Gene Perturbation Signatures 1.0 null CREM ChEA Transcription Factor Targets 1.0 null ETS1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null postcentral gyrus, left, superior lateral aspect of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.849153 TAF1_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Medial group of the dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21081 COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.901633 rostral group of intralaminar nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.856126 H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PWCY-2226-SM-2S1OP GTEx Tissue Sample Gene Expression Profiles 1.0 0.988246 ESR2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.7224 EZH2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ESR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.4431 Cerebellar atrophy, visual impairment, and psychomotor retardation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.764 GTEX-XQ8I-0826-SM-4BOOE GTEx Tissue Sample Gene Expression Profiles 1.0 1.11311 cytoplasmic part LOCATE Curated Protein Localization Annotations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A459-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-X4-A8KQ-01A-12R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE180200,GSE180201_15_v_1_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null HS852T CCLE Cell Line Gene Expression Profiles 1.0 1.96961 THAP1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.03275 YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rnf2_20123906_mouse_embryonic_stem_cell_lof_mouse_gpl1261_gse19076 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.031452 UGGT1 Pathway Commons Protein-Protein Interactions 1.0 null protein insertion into ER membrane by stop-transfer membrane-anchor sequence GO Biological Process Annotations 2023 1.0 null renal cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.751645 CTCF_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIM24_Deficiency_GDS3087_609_mouse_Hepatocellular carcinoma (HCC) tumors GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null er membrane protein complex GO Cellular Component Annotations 2015 1.0 null GTEX-OHPM-2626-SM-33HC5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00925 H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CREB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Endoplasmic reticulum COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RM2N-1826-SM-2TF5B GTEx Tissue Sample Gene Expression Profiles 1.0 3.1408 MYC ENCODE Transcription Factor Targets 1.0 null GTEX-SNOS-1726-SM-32PLN GTEx Tissue Sample Gene Expression Profiles 1.0 0.887003 metal ion transmembrane transporter activity GO Molecular Function Annotations 2025 1.0 null CTCF_fibroblast of gingiva_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE222758_0_v_3_clofazimine_human RummaGEO Drug Perturbation Signatures 1.0 null oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04766 GTEX-WFON-1026-SM-4LVMD GTEx Tissue Sample Gene Expression Profiles 1.0 0.894196 GSE193993_0_v_7_sstr2_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_medulloblastoma_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUN_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H4C12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29106 1,3-beta-D-glucan synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.721 POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-73-TX58_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.280921 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null establishment of localization GO Biological Process Annotations 2015 1.0 null TSKU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15911 GTEX-QLQ7-1926-SM-2S1R6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.55242 H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.20879 GSE164521_0_v_1_nitric oxide_mouse RummaGEO Drug Perturbation Signatures 1.0 null FOXO1::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.2598 hsa-miR-1321 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GSE103068_5_v_3_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null Foxj3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.0039 Cytosolic creatine kinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.706 CCT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66079 SPG21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05049 MED13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01947 H3K27me3_megakaryocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of skin of abdomen_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-97-7554-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKHEP1_LIVER CCLE Cell Line Proteomics 1.0 6.97741 CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71491 Primary somatosensory area, upper limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03597 SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.857769 H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE168171,GSE168173_0_v_1_ddx41_human RummaGEO Gene Perturbation Signatures -1.0 null gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055395 MDAMB361 CCLE Cell Line Gene CNV Profiles -1.0 -1.75598 Frt TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.056 Ventromedial hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0486 GSE71491_0_v_1_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.858345 496100436_FWM_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.2959 RAD21_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE179002_0_v_1_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Anteromedial nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21788 SNU-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.50025 H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null OB olfactory fiber layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.64335 CTCF_fibroblast of foreskin _hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null single-organism localization GO Biological Process Annotations 2015 1.0 null GTEX-NFK9-0006-SM-3GACS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17803 Primary visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26918 CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-18-3408-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-DX-A2IZ-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10709142-41556_2023_1281_MOESM2_ESM.xlsx-Supplementary_Table_1-CLUSTER_2_MAF_downregulated_MAF Rummagene Transcription Factor Associations 2026 1.0 null SSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05598 PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-RWS6-0526-SM-4GIAJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.14766 VZ in midcingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06443 GSE114883_1_v_5_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Rhabdomere COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.715 pioglitazone_rattus norvegicus_gpl341_gse21329 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8043-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.27762 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIM28_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of PHyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16881 H3K27ac_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_foreskin fibroblast_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE184356_3_v_0_tfam_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.10628 H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE68155_3_v_2_gpr3_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null localization GO Biological Process Annotations 2015 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-46-3769-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Integral component of external side of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.673 TBL1XR1 ENCODE Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-7726-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU601 CCLE Cell Line Gene CNV Profiles 1.0 1.42388 Anteromedial visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56706 H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12864_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial geniculate complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.30401 MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CLOCK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18795 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NCIH28 CCLE Cell Line Gene CNV Profiles 1.0 1.58066 GTEX-PWOO-0826-SM-48TCL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09544 Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3I0-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4397-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE235066_4_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.5701 H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OXRL-2126-SM-3NM98 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18331 Perturb_252_KD_USP18_SRP364866 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE198165,GSE198166_9_v_10_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.42365 H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X8HC-1626-SM-46MWE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20865 Palisade parenchyma TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.595 Integral component of endoplasmic reticulum membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 ZFX_KD_GSE43021_130_human_NOMO1 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null organelle LOCATE Curated Protein Localization Annotations 1.0 null GSE198165,GSE198166_9_v_1_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE196699_0_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC8314029-12931_2021_1797_MOESM5_ESM.xlsx-DE_genes_in_ACDMPV-Gene_name_FOXF1 Rummagene Transcription Factor Associations 2026 1.0 null KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12258 YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARRB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20263 Main olfactory bulb, outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1869 NASH_Liver_GSE24807 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.84251 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.49067 NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.32642 Posterior parietal association areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.78799 GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05793 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09062 LN-229 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.844092 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4726-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.990317 GSE123022,GSE123030_2_v_6_trem2_mouse RummaGEO Gene Perturbation Signatures 1.0 null YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_6170_KD_PROX1_SRP073100 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.75564 gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.32912 Acute Myeloid Leukemia_LAML_TCGA-AB-2807-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.055371 GTEX-RM2N-0326-SM-48FD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.951247 TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS19BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38954 KP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28519 POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142210_9_v_10_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE232472_1_v_2_apoe_mouse RummaGEO Gene Perturbation Signatures -1.0 null GABPA_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PEX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53473 GTEX-V1D1-0226-SM-4JBHG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12336 whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 Rarg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 57.1458 ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.65087 IRF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.8675 GSE203308_4_v_3_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null USF2 ENCODE Transcription Factor Targets 1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MO-0626-SM-4DM6P GTEx Tissue Sample Gene Expression Profiles 1.0 1.2293 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_2_TurboID_10m_ERM_proteome-Gene_Name_ETV5 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-R53T-2026-SM-3GIJF GTEx Tissue Sample Gene Expression Profiles 1.0 2.56203 CTCF_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Toremifene Citrate_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0116971 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S7SF-2226-SM-3K2BG GTEx Tissue Sample Gene Expression Profiles 1.0 1.58051 GSE223008_9_v_1_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RWS6-1126-SM-47JXC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00945 GRPR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15534 GTEX-QCQG-1926-SM-2S1PI GTEx Tissue Sample Gene Expression Profiles 1.0 0.842648 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.80538 superficial stratum of r3BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01621 RUNX2-22187159-PCA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SQ-A6I4-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.16234 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.944032 periventricular stratum of the VAP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06369 EB2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.861243 Perturb_14541_KD_MTHFD2_SRP287895 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE249338_1_v_0_cd44_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Posterior parietal association areas, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65982 MTA3 ENCODE Transcription Factor Targets 1.0 null YY2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.5473 CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Edinger-Westphal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.16016 HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6473-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-V955-2626-SM-3NM9F GTEx Tissue Sample Gene Expression Profiles 1.0 1.94326 GSE134214_0_v_1_ell2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null layer 1 of LPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1973 outer SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.875727 NANOGP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53335 GSE184884_6_v_5_gps2_mouse RummaGEO Gene Perturbation Signatures 1.0 null KLF14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 135.008 GTEX-PWN1-0226-SM-2S1OZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.842001 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A3GJ-01A-21R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RRP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09671 GTEX-QDT8-1026-SM-43V6X GTEx Tissue Sample Gene Expression Profiles 1.0 1.70411 GSE224969,GSE224971_0_v_5_chtop_mouse RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1063 GSE223008_7_v_1_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null Leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051612 SG in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.60054 GSE84148,GSE96938_3_v_1_nrros_mouse RummaGEO Gene Perturbation Signatures -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VI-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Medial geniculate complex, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.11656 GSE217132_0_v_1_pfkfb4_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null LOX-1_OE_GDS4262_432_human_HAECT - aortic endothelial cell line - 2 Hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.87074 GSE148200_3_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.905019 H3K14ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mononuclear cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.117333 GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01097 GSE228181_4_v_5_idh1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE235596_0_v_1_pikfyve_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Ebolavirus(ZEBOV)_3day_Liver_None_GSE57214 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.96725 golgi apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.198325 GSE161800_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null ventrolateral part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.81583 endosomal part GO Cellular Component Annotations 2015 1.0 null GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -0.839754 JAK2_mutant_40_GSE11003 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.81252 hsa-miR-3974 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Blood TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null L-363 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.88665 H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T8EM-0426-SM-4DM7E GTEx Tissue Sample Gene Expression Profiles 1.0 1.24076 GSE239844_7_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE154074_2_v_4_bleomycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null SW948 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.87835 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.1754 A427 COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-548aj TargetScan Predicted Conserved microRNA Targets 1.0 0.274552 GTEX-OHPN-0011-R2A-SM-2I5FB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.969933 SKNO1 DepMap CRISPR Gene Dependency 1.0 2.38138 integral component of membrane GO Cellular Component Annotations 2015 1.0 null KARPAS1718 DepMap CRISPR Gene Dependency 1.0 2.07034 Endosome COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 ventrolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.5092 H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BF-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4427 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 Signal peptidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.131 GSE151612_4_v_2_pracinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -2.85022 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5083-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.8473 GTEX-QV31-1626-SM-2S1QC GTEx Tissue Sample Gene Expression Profiles 1.0 0.985865 IPC298 DepMap CRISPR Gene Dependency 1.0 2.05618 GTEX-NL3H-0011-R4a-SM-2I3GK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.840769 17683608-TableS3 GeneSigDB Published Gene Signatures 1.0 null Ventral anterior-lateral complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34345 substrate-specific transporter activity GO Molecular Function Annotations 2015 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KC-A7F5-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-Q2AH-1026-SM-48TZI GTEx Tissue Sample Gene Expression Profiles 1.0 0.889698 CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NDUFA12 Pathway Commons Protein-Protein Interactions 1.0 null POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-V1D1-2126-SM-4JBH4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55193 hsa-miR-4520b-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.348832 hsa-miR-3666 TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE142210_9_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pi Mi complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.956 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A97G-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MM485 DepMap CRISPR Gene Dependency 1.0 2.07112 GTEX-OOBJ-0008-SM-3NB26 GTEx Tissue Sample Gene Expression Profiles 1.0 1.3407 CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6263 GTEX-XXEK-1126-SM-4BRUX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24688 H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUDHL5 DepMap CRISPR Gene Dependency 1.0 2.08009 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3443-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WFG8-1926-SM-4LVM1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33381 Lung adenocarcinoma_LUAD_TCGA-64-1678-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-RREB1_mod_RREB1 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-144 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RVPU-0011-R5A-SM-2XCAD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03341 GSE236815_1_v_0_panobinostat_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-Q2AG-0005-SM-33HBX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.977885 hsa-miR-519b-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 POU6F2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05254 H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null mantle zone of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48541 NCI-H1581 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.03572 H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WEY5-1926-SM-3GIL8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11956 PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null NCIH1184 CCLE Cell Line Gene Expression Profiles -1.0 -1.50462 GTEX-RU72-0011-R2A-SM-2TF6O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05828 GSE198982,GSE198986_1_v_2_daunorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF281 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 185.97 organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041807 NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.828336 GSE211128_9_v_0_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null PMC8314029-12931_2021_1797_MOESM5_ESM.xlsx-DE_genes_in_ACDMPV-Gene_stable_ID_FOXF1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Intellectual disability DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.121 UBC Pathway Commons Protein-Protein Interactions 1.0 null GSE173810_4_v_1_igf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null dorsal motor nucleus of the vagus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.885414 POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BFTC-905 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.2477 EP300_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00796 HDAC2_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16071 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I0-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Kidney Chromophobe_KICH_TCGA-KN-8419-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5514-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.79217 hsa-miR-1207-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GTEX-S3XE-1826-SM-3K2B4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.90328 HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.71229 granular layer of rostral dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2074 creb1_22108299_heart_left_ventricle_lof_mouse_gpl1261_gds3660 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -1.12519 histiocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.821921 GSE207582_4_v_3_testosterone_mouse RummaGEO Drug Perturbation Signatures 1.0 null microglia TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.437589 Ventral posterior complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08356 inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.19095 anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.90454 GTEX-PVOW-0006-SM-3NMB8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57478 GSE156115_0_v_3_igf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE111247_2_v_9_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null subparafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.943428 Signal recognition particle, endoplasmic reticulum targeting COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.738 CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null paracentral lobule, posterior part, left, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.20346 GTEX-OOBJ-0426-SM-3NB1S GTEx Tissue Sample Gene Expression Profiles 1.0 1.2345 Prostate adenocarcinoma_PRAD_TCGA-EJ-5515-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE130383_1_v_0_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WH7G-0626-SM-4LVMO GTEx Tissue Sample Gene Expression Profiles 1.0 0.880872 JURLMK1 DepMap CRISPR Gene Dependency 1.0 2.14461 CTCF_GM19240_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.41763 H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferior rostral gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.926375 H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SKNMM DepMap CRISPR Gene Dependency 1.0 2.08926 GSE161864,GSE161866_4_v_3_ror2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE150134_1_v_0_scn5a_human RummaGEO Gene Perturbation Signatures -1.0 null GSE90019,GSE90020_5_v_2_phf8_mouse RummaGEO Gene Perturbation Signatures 1.0 null Liver Diseases CTD Gene-Disease Associations 1.0 1.39422 CDK9_knockdown_71_GSE21751 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 0.886593 estradiol_homo sapiens_gpl570_gse5102 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-30b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 Perturb_4303_KO_Serpine1_SRP179032 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.41407 medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.30703 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CPSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14996 H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO 794 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.873966 Compound eye TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.92 Lung squamous cell carcinoma_LUSC_TCGA-66-2769-01A-02R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VCP Pathway Commons Protein-Protein Interactions 1.0 null H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE102870_7_v_0_nr1h4_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF417 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.6336 endoplasmic reticulum membrane GO Cellular Component Annotations 2023 1.0 null GSE117212,GSE117214_0_v_1_zbtb1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-Gene_AR Rummagene Transcription Factor Associations 2026 1.0 null GAMG_CENTRAL_NERVOUS_SYSTEM CCLE Cell Line Proteomics 1.0 5.55088 H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOSB::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.4253 HS695T CCLE Cell Line Gene CNV Profiles 1.0 2.21341 GTEX-UPK5-1526-SM-4JBJA GTEx Tissue Sample Gene Expression Profiles 1.0 0.844914 USP54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58069 SW1271 CCLE Cell Line Gene CNV Profiles 1.0 1.74121 inferior occipital gyrus, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04689 STAT1 ENCODE Transcription Factor Targets 1.0 null 1321N1 CCLE Cell Line Gene CNV Profiles -1.0 -1.61993 JUN_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.919536 GSE158834_12_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_GM12872_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH2126 CCLE Cell Line Gene Expression Profiles 1.0 1.40315 GSE217378_2_v_0_lin28b_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE206784_3_v_4_ninl_human RummaGEO Gene Perturbation Signatures 1.0 null whole plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.06036 Endometrial cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.716 MKN45 CCLE Cell Line Gene CNV Profiles -1.0 -1.42192 H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null striatum_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.28195 GSE195743_3_v_2_lhx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE180200,GSE180201_3_v_0_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null Jalili syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.061 GSE248045,GSE248046_0_v_1_runx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null membrane-bounded vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.057828 OVCA 420 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.875315 KRIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06462 hsa-miR-4432 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.056834 ATF2 ENCODE Transcription Factor Targets 1.0 null YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU72-1426-SM-46MUF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6976 GTEX-PWN1-1826-SM-2S1PE GTEx Tissue Sample Gene Expression Profiles 1.0 1.15027 GSE183176_0_v_1_glutamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null SIX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.3032 PRDM9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 198.436 GTEX-RWSA-2426-SM-47JXR GTEx Tissue Sample Gene Expression Profiles -1.0 -2.00843 Subparafascicular nucleus, magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08291 GSE142588_2_v_1_cinobufagin_human RummaGEO Drug Perturbation Signatures 1.0 null pancreas_6b HPA Tissue Sample Gene Expression Profiles -1.0 -1.02417 SAS DepMap CRISPR Gene Dependency 1.0 2.25337 hippocampus (hippocampal formation)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.920687 GTEX-RNOR-1426-SM-48FDJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7344 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3440-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1734 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03141 GSE174498,GSE174500_0_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null SP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08078 r6 part of rostral ventromedial reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23103 UOK101 DepMap CRISPR Gene Dependency 1.0 2.22812 GSE179002_2_v_6_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE223008_5_v_1_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null Magnocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25909 U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06898 GSE98898_8_v_1_hoxa1_human RummaGEO Gene Perturbation Signatures -1.0 null FCF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03469 H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-7886-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE122378_0_v_1_carmil3_mouse RummaGEO Gene Perturbation Signatures -1.0 null CCRF-SB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.55076 E2F4 ENCODE Transcription Factor Targets 1.0 null GSE48812_0_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NUGC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.2903 integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.048757 GSE229309,GSE229314_4_v_1_elavl1_human RummaGEO Gene Perturbation Signatures -1.0 null H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MalFGK2 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.101 MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.973358 GSE158834_12_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Rough endoplasmic reticulum membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.861 ERMES complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.846 ZNF449 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.6343 BACH1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_12158_KD_LIN28A1_SRP061243 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.19605 MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE48812_2_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NL3H-0006-SM-2I3FW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27156 amygdaloid complex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08472 RT112_URINARY_TRACT CCLE Cell Line Proteomics 1.0 4.87049 GTEX-W5WG-2326-SM-3GIJH GTEx Tissue Sample Gene Expression Profiles 1.0 1.04742 PHB2 Pathway Commons Protein-Protein Interactions 1.0 null Anteromedial visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16647 inner CP in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27215 GSE102505_1_v_0_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_3924_KD_VPS37B/VPS37C_SRP266781 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.10886 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JK-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE179531_1_v_0_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null SNU449 CCLE Cell Line Gene CNV Profiles -1.0 -1.98442 Prostate adenocarcinoma_PRAD_TCGA-EJ-5505-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE127916_1_v_3_nras_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE242290_3_v_11_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SuperiorCervicalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.20433 orbital frontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.41939 H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.13973 E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_epithelial cell of proximal tubule_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S3XE-1526-SM-4AD5A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3608 TBXT JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.2793 GTEX-P4PP-1026-SM-3NM9O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29715 GSE153189_2_v_3_stat1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE114883_0_v_5_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null bone marrow HPA Tissue Protein Expression Profiles -1.0 -1.1008 GSE166944_0_v_2_eif4b_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE114013,GSE114014_0_v_4_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null hESC Derived CD184+ Endoderm Cultured Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.05529 GSE158834_12_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_LNCaP clone FGC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE166315_5_v_4_docetaxel_mouse RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A6UM-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventromedial preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.78155 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.987089 BHT101 CCLE Cell Line Gene Expression Profiles 1.0 2.59376 KLF5 JASPAR Predicted Transcription Factor Targets 1.0 null IRF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.3294 Entorhinal area, lateral part, layer 2a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50955 Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F0-01A-12R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210580_4_v_1_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null BD-04-NG34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.243049 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.968738 Cercarial dermatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.128 Endoplasmic reticulum protein-containing complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 HDAC2 ENCODE Transcription Factor Targets 1.0 null Cone dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.236 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r2BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30613 H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6496-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null mediodorsal nucleus of thalamus_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.08852 GSE166315_1_v_4_docetaxel_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE189859,GSE189861_1_v_2_idh1_human RummaGEO Gene Perturbation Signatures -1.0 null Rhabdomyosarcoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.915 JUND_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WEE1_druginhibition_307_GSE38972 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -0.966341 Intergeniculate leaflet of the lateral geniculate complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79279 GTEX-PVOW-0726-SM-2XCF5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.925053 KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.934177 REST ENCODE Transcription Factor Targets 1.0 null FOS ENCODE Transcription Factor Targets 1.0 null GTEX-XBED-2426-SM-4AT4O GTEx Tissue Sample Gene Expression Profiles 1.0 1.3313 dorsolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0096 20490655-ST3 GeneSigDB Published Gene Signatures 1.0 null brain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 EZH2 ENCODE Transcription Factor Targets 1.0 null divalent metal ion transport GO Biological Process Annotations 2015 1.0 null suboptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.92248 SRF_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5430-01A-02R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETV7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.5819 CTCF_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIX5_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AG-1126-SM-48U1P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2862 POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE152666,GSE152668_2_v_1_carm1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE158834_7_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE233679_6_v_2_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null Hmx2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.9245 Sox11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 39.4204 thyroid gland HPA Tissue Gene Expression Profiles 1.0 1.86826 MS751 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.15849 GSE158834_10_v_4_palm_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RUSQ-0326-SM-47JWS GTEx Tissue Sample Gene Expression Profiles 1.0 1.2405 EIF2B4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66569 GSE210580_4_v_12_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-621 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GABPA ENCODE Transcription Factor Targets 1.0 null BT474 CCLE Cell Line Gene CNV Profiles -1.0 -1.44569 magnesium ion transmembrane transporter activity GO Molecular Function Annotations 2023 1.0 null H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-ATF3_TGACGTCA_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null HA-E2F1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6WL-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ec TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.895 GTEX-XMD1-2826-SM-4AT5F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00047 Sec61 translocon complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.139 H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 1.04537 hsa-miR-1303 TargetScan Predicted Conserved microRNA Targets 1.0 0.009975 GSE128844_0_v_2_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null nrf1_22586274_liver_lof_mouse_gpl4134_gse35124 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.024154 lateral parabrachial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.824013 ChIP_JARID1A_20064375 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H3K4me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null oocyte BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.951127 MYC-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.15121 hsa-miR-30c TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 KP-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827595 mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.980928 HEL9217 CCLE Cell Line Gene Expression Profiles -1.0 -2.00278 CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFG7-2326-SM-3GIKV GTEx Tissue Sample Gene Expression Profiles 1.0 2.61022 647-V Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.90986 RFX5 ENCODE Transcription Factor Targets 1.0 null inferior frontal gyrus, opercular part, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.862338 Perturb_11620_KD_CTDSPL_SRP113334 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.40395 GTEX-S33H-1326-SM-4AD6A GTEx Tissue Sample Gene Expression Profiles -1.0 -0.878041 POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_1_BioID_ERM_proteome-Gene_Name_ETV5 Rummagene Transcription Factor Associations 2026 1.0 null GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PLZ4-1326-SM-2S1O7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.65872 metal ion transmembrane transporter activity GO Molecular Function Annotations 2023 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.902087 membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null DLD1 DepMap CRISPR Gene Dependency 1.0 2.01389 EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.50294 membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null HARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20441 HAND2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.7438 CTCF_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-WY-A858-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Taenia tecta, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36 POU2F2 ENCODE Transcription Factor Targets 1.0 null GTEX-OHPK-0426-SM-3MJH3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.964894 spleen HPA Tissue Protein Expression Profiles -1.0 -1.1008 GTEX-WHWD-2426-SM-3LK6S GTEx Tissue Sample Gene Expression Profiles 1.0 1.04707 CREB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-S32W-1926-SM-4AD63 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.881832 DMS454 CCLE Cell Line Gene CNV Profiles -1.0 -2.29789 GTEX-RVPU-0011-R1A-SM-2XCAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26388 Prostate adenocarcinoma_PRAD_TCGA-G9-6362-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09626 CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193993_1_v_2_sstr2_human RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7752-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null aminoacyl-tRNA synthetase multienzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.813 H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TKQ2-1726-SM-4DXUP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56366 ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.888728 HUH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.60508 GTEX-TKQ2-0426-SM-4DXUO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.869351 GSE57871_1_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null SP1 JASPAR Predicted Transcription Factor Targets 1.0 null intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null ETV2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6143 SW 780 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.891218 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7247-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null forebrain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null 1391_CDC23_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.638869 TBCD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15795 IRF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 52.2894 GSE95688_1_v_0_glutathione_mouse RummaGEO Drug Perturbation Signatures -1.0 null CTCF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE184892_7_v_2_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-S3XE-1626-SM-3K2AJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.22897 GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61643 vitamin c_homo sapiens_gpl570_gse11919 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XBED-1726-SM-47JYO GTEx Tissue Sample Gene Expression Profiles 1.0 0.827106 TYKNU DepMap CRISPR Gene Dependency 1.0 2.01866 SP in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.972371 BT20 CCLE Cell Line Gene CNV Profiles 1.0 2.00705 GSE153189_2_v_3_interferon gamma_mouse RummaGEO Drug Perturbation Signatures 1.0 null JC-06-ED36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.253771 GTEX-SN8G-0526-SM-32PLE GTEx Tissue Sample Gene Expression Profiles 1.0 3.17195 GTEX-PW2O-0426-SM-48TCC GTEx Tissue Sample Gene Expression Profiles 1.0 1.00011 7471_RPL39_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.687331 MKN28 DepMap CRISPR Gene Dependency 1.0 2.24212 GTEX-U3ZN-0226-SM-3DB8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33401 organelle GO Cellular Component Annotations 2015 1.0 null TAF1 ENCODE Transcription Factor Targets 1.0 null GTEX-R53T-1626-SM-3GAEW GTEx Tissue Sample Gene Expression Profiles 1.0 0.893493 mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29133 GTEX-WWYW-0426-SM-3NB31 GTEx Tissue Sample Gene Expression Profiles 1.0 1.4934 JUN_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Geniculate group, ventral thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.73874 CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.982075 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3374-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cone matrix sheath COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.061 COLO 678 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.58623 POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZSCAN16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27203 CAL-85-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03141 telencephalon TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null hsa-miR-2117 TargetScan Predicted Conserved microRNA Targets 1.0 0.03694 ZNF354C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.3125 terete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.69199 GTEX-Q2AH-1526-SM-48TZG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20049 DHX15 Pathway Commons Protein-Protein Interactions 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LI-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null IGF1R_druginhibition_47_GSE14024 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.29533 Foxj2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.3694 TCFCP2L1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Primary somatosensory area, nose Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.96192 early endosome membrane GO Cellular Component Annotations 2015 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HA-01B-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE80446_2_v_1_anakinra_mouse RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47N-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE60691_2_v_1_glutamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null testis_7f HPA Tissue Sample Gene Expression Profiles -1.0 -1.2733 HCC89 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15047 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A818-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WH7G-1926-SM-4LVMM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3618 ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Breast_vHMEC Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.977921 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MIA PACA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.828336 GTEX-XUZC-0226-SM-4BOO7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.949649 KMS-28PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.7858 H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Transcription export complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.532 endoplasmic reticulum part GO Cellular Component Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A89V-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE166944_3_v_2_eif4b_mouse RummaGEO Gene Perturbation Signatures -1.0 null f11 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.572 AU565 CCLE Cell Line Gene CNV Profiles -1.0 -1.47976 NANOG-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null OB inner plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45621 spleen BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.42519 GSE186440,GSE186443_0_v_5_daxx_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF320 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 202.983 central nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056524 GSE211128_9_v_5_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.6193 CCLP1 DepMap CRISPR Gene Dependency 1.0 2.32809 CREB1-23762244-HIPPOCAMPUS-RAT ChEA Transcription Factor Targets 2022 1.0 null Perturb_5861_KD_H3f3a_SRP133189 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.0738 layer III of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17721 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 1463 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.860664 Perturb_2699_KD_EXOSC8_ERP005752 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -10.367 Brain Lower Grade Glioma_LGG_TCGA-DU-6394-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Endoplasmic reticulum Sec complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.58 amygdaloid complex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.846265 cytoplasmic vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.057828 oocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.419242 GSE201401_2_v_0_fgfr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.947905 orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.64637 GSE200352_10_v_0_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null FUOV1 CCLE Cell Line Gene Expression Profiles -1.0 -1.48029 GSE77108_6_v_1_saha_human RummaGEO Drug Perturbation Signatures 1.0 null SP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.27112 Periderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.854 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3NI-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary somatosensory area, nose, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.69702 GSE200352_10_v_6_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null ventrolateral preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.17065 H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CREB1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE221327_10_v_11_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041965 HEC-1-A cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.568 GSE198165,GSE198166_8_v_1_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null E2F1 ChEA Transcription Factor Targets 1.0 null GTEX-POYW-0726-SM-2XCEO GTEx Tissue Sample Gene Expression Profiles 1.0 0.872773 Rhabdomyosarcoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.843 GTEX-PLZ6-0326-SM-3P61J GTEx Tissue Sample Gene Expression Profiles 1.0 0.957826 OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.25017 A-CA-04-2009(H1N1)_0Hour_None_GSE37571 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.48218 Perturb_17631_KD_Rictor_SRP224571 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Anteromedial visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18704 LMSU CCLE Cell Line Gene CNV Profiles 1.0 1.60229 CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TM-A7C3-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35308 GSE241036_4_v_2_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRL-0008-SM-3NB29 GTEx Tissue Sample Gene Expression Profiles 1.0 1.3528 GSE216273,GSE216292_0_v_2_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null PHF8 ENCODE Transcription Factor Targets 1.0 null Posterior parietal association areas, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.05032 GSE179002_4_v_1_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-548am TargetScan Predicted Conserved microRNA Targets 1.0 0.274552 CREB1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4954754-elife-15550-fig3-figsupp1-data1.xlsx-HSF1_Genes-Unnamed_18_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null GSE153189_1_v_0_interferon gamma_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null 17616640-TableS3 GeneSigDB Published Gene Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4116-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Visual areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1354 Oogenesis phase fetal germ cell_Fetal gonad_Human CellMarker Gene-Cell Type Associations 1.0 null COX5A Pathway Commons Protein-Protein Interactions 1.0 null dorsomedial nucleus, terminal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29386 CFL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03911 CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A24D-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null limbic system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.235023 macrophage BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.32455 L363 CCLE Cell Line Gene Expression Profiles 1.0 3.40543 GTEX-XUW1-1726-SM-4BOOZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0093 GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.43988 Lung adenocarcinoma_LUAD_TCGA-05-4382-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Aorta Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.34463 H3K4me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XOTO-0006-SM-4B64T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26694 germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.274045 NCIH508 CCLE Cell Line Gene Expression Profiles -1.0 -1.46854 E2F6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.3926 IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.851001 amygdaloid complex_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.50922 CAL-39 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.95245 Derlin-1 retrotranslocation complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.29 Rectum adenocarcinoma_READ_TCGA-AF-2693-01A-02R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null metal ion transport GO Biological Process Annotations 2015 1.0 null Dopamine DeepCoverMOA Drug Mechanisms of Action -1.0 -0.31 RAB26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77461 Mediodorsal nucleus of the thalamus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46684 GTEX-NPJ8-0011-R8a-SM-2HMLG GTEx Tissue Sample Gene Expression Profiles 1.0 4.03298 inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.898565 Fundus dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.41 18199711-Table3 GeneSigDB Published Gene Signatures 1.0 null Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null PMC11956947-media-4.xlsx-C_GSEA_gene_sets-TGAYRTCA_ATF3_Q6_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null PORCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.86461 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7065-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CD56+_NKCells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.41066 ZNF530 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 74.9184 Hmx3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.6731 TRIR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22118 Esophagus - Gastroesophageal Junction GTEx Tissue Gene Expression Profiles 2023 -1.0 -2.0471 GSE132369,GSE132371_3_v_0_cccp_human RummaGEO Drug Perturbation Signatures 1.0 null 5054_MICAL3_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.589836 MYC_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE179031_0_v_2_foxp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE114690_1_v_0_tnfsf14_mouse RummaGEO Gene Perturbation Signatures -1.0 null DOR 13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.844092 MZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.59204 FOSL2::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.7125 CNNM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17838 Precommissural nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40741 organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null C3A CCLE Cell Line Gene Expression Profiles -1.0 -2.09009 Rectum adenocarcinoma_READ_TCGA-DC-6682-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEC6_ENDOMETRIUM CCLE Cell Line Proteomics 1.0 2.37238 urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 PMC5732738-oncotarget-08-103415-s002.xlsx-MFC-7_DEGs-Genes_with_significantly_different_expression_between_parental_MCF-7_and_GATA3_WT_clones_with_adjusted_P_value_0_05_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.895193 Acute Myeloid Leukemia_LAML_TCGA-AB-2867-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF384 ENCODE Transcription Factor Targets 1.0 null PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE223008_5_v_12_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7123-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE153189_1_v_0_stat1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE202434,GSE202438_15_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-S7PM-0426-SM-3NM91 GTEx Tissue Sample Gene Expression Profiles 1.0 0.875306 DDX51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13459 H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RCHACV DepMap CRISPR Gene Dependency 1.0 2.23166 MRPL1 Pathway Commons Protein-Protein Interactions 1.0 null KDM4A ENCODE Transcription Factor Targets 1.0 null GTEX-T6MN-1226-SM-3NMA5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66606 GTEX-OIZI-0526-SM-2XCEG GTEx Tissue Sample Gene Expression Profiles 1.0 2.77467 Lung Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.56203 GTEX-QDVN-1126-SM-48TZ7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.913309 superficial stratum of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.90841 H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE197850_4_v_3_glucagon_human RummaGEO Drug Perturbation Signatures 1.0 null hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null sirolimus_mus musculus_gpl1261_gse5332 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PIK3CA_druginhibition_57_GSE17785 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.40804 Central amygdalar nucleus, capsular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05733 GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05281 Vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreas Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -2.6157 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1901 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XOTO-0826-SM-4B65O GTEx Tissue Sample Gene Expression Profiles -1.0 -2.59122 ID-00-IC14_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.252213 K562_PFI-1_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.014793 MA-104 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.003 POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ5-0326-SM-3P614 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15813 PATU8988T DepMap CRISPR Gene Dependency 1.0 2.24454 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20V-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null helper T-lymphocyte ProteomicsDB Cell Type and Tissue Protein Expression Profiles -1.0 -1.13779 latex TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.781063 GSE214596,GSE214598_1_v_3_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-1972 TargetScan Predicted Conserved microRNA Targets 1.0 0.632343 golgi apparatus part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.392775 KASUMI-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.91254 GSE226249_0_v_8_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null oral mucosa HPA Tissue Protein Expression Profiles -1.0 -1.1008 VDAC3 Pathway Commons Protein-Protein Interactions 1.0 null ZNRF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34406 EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3659 TargetScan Predicted Conserved microRNA Targets 1.0 0.517189 GTEX-WYJK-0426-SM-3NM9G GTEx Tissue Sample Gene Expression Profiles 1.0 1.67974 ENDOD1 Pathway Commons Protein-Protein Interactions 1.0 null kidney TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.090762 SW948 CCLE Cell Line Gene Expression Profiles -1.0 -1.5167 PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-P4PP-1826-SM-2S1NT GTEx Tissue Sample Gene Expression Profiles 1.0 1.33993 GTEX-XUW1-0726-SM-4BOP5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.908961 GTEX-T2IS-1026-SM-32QP1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.942312 hsa-miR-548f TargetScan Predicted Conserved microRNA Targets 1.0 0.404082 GSE158834_10_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE157960_0_v_3_progesterone_mouse RummaGEO Drug Perturbation Signatures 1.0 null KLE DepMap CRISPR Gene Dependency 1.0 2.04311 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A7WF-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-19a TargetScan Predicted Conserved microRNA Targets 1.0 0.454769 OVCA 429 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.849944 TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_WHI-P154_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0136824 PLAG1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 129.944 Primary somatosensory area, lower limb, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08558 OGFOD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13265 HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH2227 CCLE Cell Line Gene Expression Profiles 1.0 1.37362 OCUM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.842484 KM-H2 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.5577 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LD-01A-12R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NFK9-0326-SM-3MJGV GTEx Tissue Sample Gene Expression Profiles 1.0 1.1375 GTEX-O5YT-2126-SM-3MJGD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18356 496100626_FWM_no dementia_TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.02523 H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-922 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 TAF1_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE223008_5_v_2_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null Retinal degeneration DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.04 early endosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.404804 CTCF_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TALL-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.73999 Lung squamous cell carcinoma_LUSC_TCGA-18-3409-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null ZMIZ1 ENCODE Transcription Factor Targets 1.0 null Primary somatosensory area, lower limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00066 Medial geniculate complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65366 YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-548ac TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 OVCAR433 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.68954 H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE197850_4_v_2_glucagon_human RummaGEO Drug Perturbation Signatures 1.0 null endoplasmic reticulum COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 HCC1599 CCLE Cell Line Gene CNV Profiles 1.0 2.35757 GSE87404,GSE87812_2_v_0_hoxa9_mouse RummaGEO Gene Perturbation Signatures 1.0 null Chromosome 15q11.2 deletion syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.528 hepg2 HPA Cell Line Gene Expression Profiles -1.0 -1.12051 TOMM40 Pathway Commons Protein-Protein Interactions 1.0 null arcuate nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.37656 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CTCF_brain microvascular endothelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -2.11349 Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6WN-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_3_TurboID_1hr_ERM_proteome-Gene_Name_ETV5 Rummagene Transcription Factor Associations 2026 1.0 null primary visual cortex (striate cortex, area V1/17)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.984701 dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.27441 ZNF708 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.6478 SLF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38048 Head and Neck squamous cell carcinoma_HNSC_TCGA-WA-A7H4-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE114992,GSE114993_0_v_3_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cells - Cultured fibroblasts GTEx Tissue Gene Expression Profiles 2023 1.0 1.08657 KDM5A ChEA Transcription Factor Targets 1.0 null PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ENSG_LTF Rummagene Transcription Factor Associations 2026 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.64975 reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052712 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Lateral amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00089 TMCO6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00155 PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytoplasmic part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE169356_2_v_1_ivermectin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-QDVN-2326-SM-2S1PF GTEx Tissue Sample Gene Expression Profiles 1.0 1.45926 GSE124375_10_v_9_chd2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE226249_0_v_4_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null transport GO Biological Process Annotations 2015 1.0 null Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.2828 TPGS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27472 ELF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.899538 H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X638-0005-SM-47JX6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09597 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XN-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null testis_7a HPA Tissue Sample Gene Expression Profiles -1.0 -1.41315 GSE242083,GSE242098_3_v_1_med1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WY7C-2826-SM-3NB3Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.28272 MNT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2092 Maltose transport complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.93 GSE62843,GSE64370_0_v_3_furan_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE113106_2_v_4_dnm2_mouse RummaGEO Gene Perturbation Signatures -1.0 null K562_Carmofur_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0173693 GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04519 NFATC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.571 Lung squamous cell carcinoma_LUSC_TCGA-39-5028-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.939691 GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferior olive, medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.931475 primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.40687 USF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4657 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2 Rummagene Transcription Factor Associations 2026 1.0 null ChIP_NANOG_18347094 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null MM1S COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-34-7107-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JHOS-4 COSMIC Cell Line Gene CNV Profiles -1.0 -5.12655 Perturb_16817_KD_Glut1_SRP387907 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.98224 primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.08852 HEXIM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56813 cd4.Tcell BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.969875 GTEX-TKQ2-1526-SM-4DXUN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27468 GSE48812_0_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null RT4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.19179 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6436-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Perturb_18010_KO_miR17/miR20a/miR18a_SRP050491 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.34279 ATF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5861 CB-31-UO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.236238 SLR20 DepMap CRISPR Gene Dependency 1.0 2.14103 GTEX-WH7G-0826-SM-4LVMR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.869261 superficial stratum of LAP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28898 Skeletal Muscle Female Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.35521 hsa-miR-4671-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.436802 anterior group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.31373 hsa-miR-3938 TargetScan Predicted Conserved microRNA Targets 1.0 0.175726 NEUROG2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.934 GTEX-UPIC-0926-SM-4IHLV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.98126 GSE198165,GSE198166_0_v_3_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null ETV5::FOXO1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.948 HT Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.68371 GTEX-OOBK-0726-SM-3LK5Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.946375 organelle part GO Cellular Component Annotations 2015 1.0 null GSE159678_4_v_2_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null Hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-S4P3-1826-SM-3K2AL GTEx Tissue Sample Gene Expression Profiles 1.0 1.37558 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PUM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73456 HSPA9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92047 FOXJ2::ELF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.233 OVOL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37871 Anterolateral visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.50598 H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.840362 PMC6344081-elife-40364-supp8.xlsx-PLZF-kd_2d_Diff_Vs_Ctrl_2d-diff-Symbol_ZBTB16 Rummagene Transcription Factor Associations 2026 1.0 null PABPC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50204 POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null endosome COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GSE181513_0_v_1_usp7_human RummaGEO Gene Perturbation Signatures -1.0 null SMAD4-19686287-HaCaT-human ChEA Transcription Factor Binding Site Profiles 1.0 null H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-67-3773-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anchored component of external side of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.245 H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE102505_1_v_2_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null RD DepMap CRISPR Gene Dependency 1.0 2.07701 GSE169334,GSE169336_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null PDX1 ChEA Transcription Factor Targets 1.0 null H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles -1.0 -0.886781 CORO1C Pathway Commons Protein-Protein Interactions 1.0 null inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.19828 GSE162276_2_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPVG-2226-SM-4B65U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12538 VDAC1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal thalamus_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.861066 icSARS-Cov_Day1_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.72306 estradiol_mus musculus_gpl4134_gse23072 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-4520a-3p TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 GTEX-REY6-0726-SM-2TF4M GTEx Tissue Sample Gene Expression Profiles 1.0 1.651 GTEX-SSA3-0426-SM-32QPI GTEx Tissue Sample Gene Expression Profiles 1.0 1.61708 CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AI-1226-SM-48U14 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.8225 H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.276 A-Vietnam-1203_CIP048_RG4-2004(H5N1)HAAvirmut_7day-MOI-10^4_None_GSE37572 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.3163 Lung squamous cell carcinoma_LUSC_TCGA-43-3920-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null endoplasmic reticulum membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-U8XE-1226-SM-4E3HN GTEx Tissue Sample Gene Expression Profiles 1.0 0.844351 VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.846362 H3K4me1_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A5SI-01A-31R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.844548 NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.51898 GSE178113,GSE178116_0_v_1_atrx_mouse RummaGEO Gene Perturbation Signatures -1.0 null SC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.894245 GTEX-WL46-0011-R7A-SM-3LK7X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.966369 t60-adrenal_consensus MoTrPAC Rat Endurance Exercise Training 1.0 2.51701 ZNF467 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20156 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUW1-1326-SM-4BOO1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.831145 intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042037 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12258 C32TG Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23981 cervical carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K27me3_erythroblast_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HERC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.35036 Brain Lower Grade Glioma_LGG_TCGA-HW-7491-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null endosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.106739 H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-11A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BL-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null endoplasmic reticulum LOCATE Curated Protein Localization Annotations 1.0 null ventrolateral prefrontal cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.69461 TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.975745 GSE239844_7_v_5_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE200352_10_v_8_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ2-1026-SM-33HB7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.43898 YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-REY6-0126-SM-48FDT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64556 RCOR1 ENCODE Transcription Factor Targets 1.0 null Adrenocortical carcinoma_ACC_TCGA-PK-A5HA-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Endoplasmic reticulum membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GTEX-SNMC-1526-SM-2XCFN GTEx Tissue Sample Gene Expression Profiles 1.0 2.24242 GSE148066,GSE157787_0_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SOX2-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perireunensis nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.48709 EP300 ENCODE Transcription Factor Targets 1.0 null GSE76771_1_v_3_atf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0776 liver_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.01677 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer II of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.34067 GSE145311_1_v_3_glutathione_mouse RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pancreas HPA Tissue Gene Expression Profiles -1.0 -1.34828 CTCF_fibroblast of the aortic adventitia_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRC complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.062 H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SUZ12 ENCODE Transcription Factor Targets 1.0 null WHSC1 ENCODE Transcription Factor Targets 1.0 null GTEX-TSE9-0226-SM-3DB84 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07439 H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OIZH-0726-SM-3NB1I GTEx Tissue Sample Gene Expression Profiles 1.0 1.48476 H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20R-11A-11R-A16R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE142210_9_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null cd8.Tcell BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.33651 CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.85116 cell part LOCATE Curated Protein Localization Annotations 1.0 null inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.42047 H3K4me1_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE221327_10_v_9_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null JHH-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.888448 Methionine CTD Gene-Chemical Interactions 1.0 null GSE224969,GSE224971_3_v_7_chtop_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-4697-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XV7Q-1226-SM-4BRVT GTEx Tissue Sample Gene Expression Profiles 1.0 0.874776 GTEX-RWSA-2026-SM-47JX8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10599 T84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.03828 liver ProteomicsDB Cell Type and Tissue Protein Expression Profiles -1.0 -0.950043 MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Entorhinal area, lateral part, layer 2b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56355 GSE226249_5_v_6_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null r7 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19654 GSE139455_2_v_5_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null medial subdivision of area 10 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04515 PHF8-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-QEG4-1226-SM-2S1P6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.27005 GSE115542_5_v_4_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null MDAMB175VII CCLE Cell Line Gene Expression Profiles -1.0 -1.45311 A549_ENMD-2076_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.016058 CTCF_GM12864_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPIC-0326-SM-4IHJ9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.53968 Kidney Diseases CTD Gene-Disease Associations 1.0 1.03567 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SJXC-0726-SM-2XCFJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.848393 Pancreatic adenocarcinoma_PAAD_TCGA-IB-A7LX-01A-12R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bardet-Biedl syndrome 12 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.404 GSE246461,GSE246463_5_v_2_mecp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Interphotoreceptor matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.76 GSE217873_1_v_0_nusap1_human RummaGEO Gene Perturbation Signatures -1.0 null CEBPD ENCODE Transcription Factor Targets 1.0 null H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE209973_1_v_0_glutamine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-RWSA-1426-SM-47JXA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50682 CTCF_keratinocyte_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4XX-0005-SM-3NMCS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.968079 GTEX-XAJ8-1326-SM-47JYT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76564 CHD2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.44244 H3K79me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OVCA 429 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00137 TDRD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23156 ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE128634,GSE128636_1_v_3_foxo1_human RummaGEO Gene Perturbation Signatures 1.0 null nuclear outer membrane-endoplasmic reticulum membrane network COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PW2O-0226-SM-48TC7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.929764 NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.901633 anterior olfactory area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48541 GTEX-OOBJ-1826-SM-3NB1C GTEx Tissue Sample Gene Expression Profiles 1.0 1.86961 JMSU1_URINARY_TRACT CCLE Cell Line Proteomics 1.0 6.97741 17616640-TableS1 GeneSigDB Published Gene Signatures 1.0 null 8157_SMC3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.567416 dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.10431 CTCF_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UPF3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49715 A172 CCLE Cell Line Gene CNV Profiles -1.0 -1.93675 7893_SEM1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.628579 protein insertion into ER membrane GO Biological Process Annotations 2025 1.0 null GSE226091,GSE226092_0_v_4_sall1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-7138-01A-41R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null urinary tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.080312 posteroventral (inferior) parietal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.831722 ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IC-08-NY46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.21514 efo21 HPA Cell Line Gene Expression Profiles 1.0 2.01858 Lung squamous cell carcinoma_LUSC_TCGA-37-4132-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100593_TCx_no dementia_TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.23635 SAM complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.801 GTEX-S4UY-0008-SM-3NM8H GTEx Tissue Sample Gene Expression Profiles 1.0 1.36443 cerebral lobe TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE135334,GSE136010_2_v_3_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Blue cone monochromacy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.751 CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GET complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.897 PML ENCODE Transcription Factor Targets 1.0 null hsa-miR-300 TargetScan Predicted Conserved microRNA Targets 1.0 0.078844 LA-42-ER00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.295704 USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles -1.0 -2.47272 GSE233679_6_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null SUDHL4 DepMap CRISPR Gene Dependency 1.0 2.22023 GSE118548_1_v_3_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PLZ5-1526-SM-3P5ZX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00036 CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-337-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 Stat4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.3512 UBXN10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00914 Choline CTD Gene-Chemical Interactions 1.0 null GTEX-XMK1-2026-SM-4B65K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38105 GSE232223_1_v_0_letmd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CKAP4 Pathway Commons Protein-Protein Interactions 1.0 null HT DepMap CRISPR Gene Dependency 1.0 2.17366 GTEX-P4PP-0426-SM-3NM9H GTEx Tissue Sample Gene Expression Profiles 1.0 1.209 HCC38 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of villous mesenchyme_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9823215-mmc4.xlsx-Sheet1-List_of_genes_commonly_upregulated_by_wild_type_and_zinc_finger_mutant_of_LIN28A_LIN28A Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE233679_6_v_10_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null KCL22 DepMap CRISPR Gene Dependency 1.0 2.44121 inner SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.897201 Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Perturb_15489_KD_SMARCA4_SRP218853 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.16592 HCC1143 CCLE Cell Line Gene CNV Profiles 1.0 2.09599 superficial stratum of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.50848 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S32W-0526-SM-4AD6F GTEx Tissue Sample Gene Expression Profiles 1.0 0.888122 GTEX-T6MN-2026-SM-4DM7L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.8225 primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.935835 GTEX-OXRO-0011-R2A-SM-3NB1W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18081 r2 part of trigeminal sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01942 GTEX-W5WG-2226-SM-4LMI3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.981419 CREB1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO 201 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00061 GSE112761,GSE112767_1_v_3_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.60141 TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PDIA3 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-526a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 4951_MED28_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.536813 GSS CCLE Cell Line Gene CNV Profiles -1.0 -2.58732 GTEX-WFG7-2426-SM-3GIL2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12812 GTEX-U8XE-0126-SM-4E3I3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51577 metal ion transport GO Biological Process Annotations 2023 1.0 null SZ in rostral cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.867698 BCL6-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-SNMC-1326-SM-2XCFK GTEx Tissue Sample Gene Expression Profiles 1.0 0.953703 GTEX-S7PM-0006-SM-3NM8C GTEx Tissue Sample Gene Expression Profiles -1.0 -0.92306 IKZF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.6732 HS 852.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.1486 GABPA_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S95S-1126-SM-4B64E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39113 GTEX-U8XE-1526-SM-4E3HT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2239 SKBR3 CCLE Cell Line Gene CNV Profiles -1.0 -1.54379 H3K4me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE163052,GSE163198_4_v_7_hira_mouse RummaGEO Gene Perturbation Signatures -1.0 null QA-07-KC40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203215 hippocampus (hippocampal formation)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.848959 CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null supramammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.28314 GSE79291_1_v_2_streptozotocin_mouse RummaGEO Drug Perturbation Signatures 1.0 null EB2 CCLE Cell Line Gene Expression Profiles -1.0 -1.49632 hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.907388 GTEX-U4B1-1526-SM-4DXSL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04542 POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SNMC-1026-SM-4DM7K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3403 plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060318 H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null GSE189653,GSE203344_5_v_1_fluoxetine_mouse RummaGEO Drug Perturbation Signatures -1.0 null NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00061 CAY10683 DeepCoverMOA Drug Mechanisms of Action 1.0 0.28 hsa-miR-4763-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GSE140937,GSE140938_0_v_2_slfn11_human RummaGEO Gene Perturbation Signatures 1.0 null GSE158834_1_v_4_palm_human RummaGEO Gene Perturbation Signatures 1.0 null GSE226249_5_v_3_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null STAT4-19710469-TH1 cell mouse-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-212 TargetScan Predicted Conserved microRNA Targets 1.0 0.265648 LP1 CCLE Cell Line Gene Expression Profiles 1.0 1.8101 TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null prostate gland ProteomicsDB Cell Type and Tissue Protein Expression Profiles -1.0 -1.13454 Primary somatosensory area, unassigned, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07483 POLR2A_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Necrosis CTD Gene-Disease Associations 1.0 1.53989 PTPN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25143 H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE157555,GSE157556_0_v_1_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null TBP_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.38756 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052471 hsa-miR-4480 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 ZNF263 ENCODE Transcription Factor Targets 1.0 null Posterior parietal association areas, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.00958 GTEX-P4QT-2026-SM-3NMCJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.870257 POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB ENCODE Transcription Factor Targets 1.0 null H3K4me3_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE87404,GSE87812_1_v_3_hoxa9_mouse RummaGEO Gene Perturbation Signatures 1.0 null SEL1L Pathway Commons Protein-Protein Interactions 1.0 null SNU668 CCLE Cell Line Gene Expression Profiles 1.0 1.61547 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7432-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.855332 Integral component of endoplasmic reticulum membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.876 NCIH929 CCLE Cell Line Gene CNV Profiles 1.0 1.36537 Prdm5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.4027 JMJD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21577 NFYB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.96334 Superior colliculus, motor related, deep white layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05058 POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein insertion into ER membrane by stop-transfer membrane-anchor sequence GO Biological Process Annotations 2025 1.0 null Streptococcal tonsillitis_Tonsillar Lymphoid Tissue_GSE11494 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.62198 GTEX-QLQW-1026-SM-447A9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25896 THAP1 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66T-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Thalamus, sensory-motor cortex related Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07552 HSD17B7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20875 posteromedial visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46684 GTEX-RVPV-0006-SM-2TF6Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06949 hsa-miR-603 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 BRCA1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FBXO6 Pathway Commons Protein-Protein Interactions 1.0 null Huh-7.5 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.12 H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-5279-01A-03R-2347-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-5264-01A-01R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H4K20me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_foreskin fibroblast_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Zfp961 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.0755 cerebellum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.25253 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.971568 H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE153189_2_v_0_interferon gamma_mouse RummaGEO Drug Perturbation Signatures 1.0 null central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.74292 OUMS23 CCLE Cell Line Gene Expression Profiles -1.0 -2.03216 CTCF_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.02087 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7255-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 2.78964 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00164 H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OXRO-0011-R9A-SM-3NB1X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860507 anterior (rostral) cingulate (medial prefrontal) cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02385 POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00142 GSE143782_3_v_4_calcitriol_human RummaGEO Drug Perturbation Signatures -1.0 null H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.23543 PML_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUN_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216043_3_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE227592_10_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null arcuate nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.26578 SPI1_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE163862_0_v_3_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Ommatidium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.828 superficial stratum of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49578 inorganic cation transmembrane transporter activity GO Molecular Function Annotations 2025 1.0 null EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9795333-mmc4.xlsx-HUES66_Ex_CTIP2_C3-X-linked_genes_BCL11B Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DR-A0ZM-01A-12R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null NCI-H847 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.93155 GSE148066,GSE157787_8_v_7_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null renal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.75371 Perturb_7214_KD_RC3H1/RC3H2_SRP058191 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.75664 NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05525 16397240-SuppTable9 GeneSigDB Published Gene Signatures 1.0 null CCKBR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24132 MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.8745 6652_PPP1R10_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.17676 H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XOTO-0011-R5A-SM-4B657 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.933036 GSE129725_4_v_0_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SK23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.889685 GSE157383_3_v_2_abemaciclib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PWOO-0326-SM-48TDB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.970473 Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LB-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE151494_1_v_3_nrp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null mediodorsal nucleus of thalamus_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.985806 Field CA3, stratum lucidum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30716 GTEX-RU72-0006-SM-2TF65 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.970414 GTEX-WEY5-2126-SM-3GILK GTEx Tissue Sample Gene Expression Profiles 1.0 2.67619 intracellular part GO Cellular Component Annotations 2015 1.0 null NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.54689 H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPT6-2226-SM-4B66R GTEx Tissue Sample Gene Expression Profiles 1.0 0.880286 LAMA-84 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.50488 Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CTCF_GM12873_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZH-1826-SM-2YUNP GTEx Tissue Sample Gene Expression Profiles 1.0 1.15988 hel HPA Cell Line Gene Expression Profiles -1.0 -1.42901 A549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827595 H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null amygdaloid complex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.10933 H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4717-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EF-01A-12R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF75D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.1692 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7061-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.945703 GSE190384,GSE190386_0_v_8_fulvestrant_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null OB glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36804 H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE144120_3_v_1_plcg2_human RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of PO2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.33007 POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mobilized_CD34_Primary_Cells_Female Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 2.11583 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE100102_2_v_6_cgas_mouse RummaGEO Gene Perturbation Signatures 1.0 null PATZ1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 214.44 Lung squamous cell carcinoma_LUSC_TCGA-66-2753-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S7SF-0008-SM-3NM8T GTEx Tissue Sample Gene Expression Profiles 1.0 1.2088 r2 part of principal trigeminal sensory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.12145 membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.875467 SUDHL8 DepMap CRISPR Gene Dependency 1.0 2.30823 hsa-miR-520d-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.140752 PDX1-19855005-MIN6-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10U-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-RP-A690-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null outer CP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.958266 NFATC3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4403 GTEX-WHSE-0006-SM-3NMBW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4452 primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.902087 HUPT4 CCLE Cell Line Gene CNV Profiles 1.0 1.93217 layer 2 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27301 PATU8988S CCLE Cell Line Gene Expression Profiles -1.0 -1.67128 CTCF_GM10266_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.3766 GTEX-OHPK-0226-SM-3MJH6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.978002 GSE123022,GSE123030_8_v_0_trem2_mouse RummaGEO Gene Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.17548 SG in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.72419 GTEX-RWSA-0526-SM-2XCBC GTEx Tissue Sample Gene Expression Profiles 1.0 0.980652 ZNF341 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.704 outer plexiform zone in extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.908802 GTEX-RTLS-0426-SM-2TF5K GTEx Tissue Sample Gene Expression Profiles 1.0 1.95049 CTCF_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE242647_2_v_3_adiponectin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE220914_2_v_0_zdhhc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE248045,GSE248046_6_v_2_runx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null D283MED CCLE Cell Line Gene Expression Profiles -1.0 -1.55599 H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4719 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 CTCF_BE2C_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE153189_2_v_0_stat1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XUW1-1526-SM-4BOOY GTEx Tissue Sample Gene Expression Profiles 1.0 0.952024 Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-5631-01A-01R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE127970_1_v_0_ebf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K9ac_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_15089_KD_TFAM_SRP337625 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.3062 REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-PAX6_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_PAX6 Rummagene Transcription Factor Associations 2026 1.0 null rnf2_20805357_megakaryocytic_l8057_lof_mouse_gpl1261_gse33659 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.342455 496100613_TCx_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.40288 TF1 DepMap CRISPR Gene Dependency 1.0 2.1236 magnesium ion transport GO Biological Process Annotations 2025 1.0 null CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PBX3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE203329_2_v_1_mettl5_human RummaGEO Gene Perturbation Signatures -1.0 null r7 part of cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03134 MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.95277 PAPOLG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23825 GSE198165,GSE198166_6_v_3_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null TMBIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06871 OB mitral cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07775 GTEX-WRHK-1726-SM-3MJFK GTEx Tissue Sample Gene Expression Profiles 1.0 2.39935 Lung squamous cell carcinoma_LUSC_TCGA-22-4607-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.970428 cerebral cortex TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ventrolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16764 ChIP_TCFCP2L1_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null DHX34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08997 cell part LOCATE Predicted Protein Localization Annotations 1.0 null JUND_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-NEUN_UNIQUE_DYS_GENES-OLIG2_TLE_vs_TL_log2FoldChange_1_padj_0_1_OLIG2 Rummagene Transcription Factor Associations 2026 1.0 null MZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10057 hsa-miR-4519 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 PROX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54593 IRF8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.7331 BC-25-VR48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.218262 1197_CARS_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.3073 hsa-miR-548x TargetScan Predicted Conserved microRNA Targets 1.0 0.274552 SP in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14736 H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC6365116-aav5590_Table_S1.xlsx-E_DOT1L_spec-Unnamed_2_DOT1L Rummagene Transcription Factor Associations 2026 1.0 null Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.96459 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.51029 hippocampus (hippocampal formation)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.933569 PC-3 cell ProteomicsDB Cell Type and Tissue Protein Expression Profiles 1.0 1.10905 Paraventricular hypothalamic nucleus, parvicellular division, medial parvicellular part, dorsal zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4067 orbital frontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.44486 hippocampus (hippocampal formation)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28805 H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.5318 GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1889 H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null IRF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.971 POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7013_RAB20_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.527401 CTCF_fibroblast of villous mesenchyme_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-Netherlands-602-2009(H1N1)_30Hour_None_GSE40844 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.22552 posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.10469 layer 3 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18176 liver GTEx Tissue Gene Expression Profiles -1.0 -2.10021 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11738 Entorhinal area, lateral part, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10076 GTEX-T2YK-0005-SM-32QOV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.947278 MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6516-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC6080909-JEM_20171312_TableS1.xlsx-miR-196_predicted-Table_S1_miR-196a_b_predicted_targets_by_PITA_PicTar_TargetScan_and_DIANA_prediction_algorithms_ZFP1 Rummagene Transcription Factor Associations 2026 1.0 null amygdaloid complex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.32308 MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE98898_7_v_1_hoxa1_human RummaGEO Gene Perturbation Signatures -1.0 null JUND_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRN-0005-SM-2I5EU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42806 Retrosplenial area, ventral part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19356 b220.bcell BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.902324 GSE189653,GSE203344_2_v_1_fluoxetine_mouse RummaGEO Drug Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.830285 RBBP5 ENCODE Transcription Factor Targets 1.0 null EFO21 CCLE Cell Line Gene CNV Profiles 1.0 1.5217 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null GSE60837_6_v_4_bcl9_mouse RummaGEO Gene Perturbation Signatures -1.0 null PAT complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.882 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-POMQ-2126-SM-2S1OJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.98283 ZNF202 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47465 16651414-Supp3 GeneSigDB Published Gene Signatures 1.0 null CD34+ BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.73605 hsa-miR-3162-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 ZCCHC18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21933 CTCF_MCF-7_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.10809 tail-anchored membrane protein insertion into ER membrane GO Biological Process Annotations 2025 1.0 null H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC12629827-mmc8.xlsx-DDR2_KD-symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null JUND_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1 ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HY-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE134615_1_v_0_lats1_human RummaGEO Gene Perturbation Signatures -1.0 null Golgi apparatus COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 PNGase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.516 A549_GSK J1_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.011858 CCNT2 ENCODE Transcription Factor Targets 1.0 null SRF JASPAR Predicted Transcription Factor Targets 1.0 null PMC5691083-41467_2017_859_MOESM6_ESM.xlsx-FDR_0_1_RELB_RNAi-Unnamed_1_RELB Rummagene Transcription Factor Associations 2026 1.0 null SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of mammary gland_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELAVL1 Pathway Commons Protein-Protein Interactions 1.0 null H3K79me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-DC-5869-01A-01R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU1041 DepMap CRISPR Gene Dependency 1.0 2.28379 GTEX-NPJ8-1826-SM-2YUNC GTEx Tissue Sample Gene Expression Profiles 1.0 1.90056 GSE149124,GSE149128_2_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null PK-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.51314 single-organism transport GO Biological Process Annotations 2015 1.0 null Primary visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02937 H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of mammary gland_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2917-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.88609 H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE149264,GSE149267_9_v_3_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-130a TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 H3K27ac_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ETS1 ENCODE Transcription Factor Targets 1.0 null GSE102486,GSE102490_1_v_5_setdb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-T5JC-0626-SM-3NMA6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.982829 GTEX-O5YT-1826-SM-32PK9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.48713 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.19095 Retrosplenial area, ventral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13751 GTEX-OHPK-1826-SM-2YUMR GTEx Tissue Sample Gene Expression Profiles 1.0 1.28218 H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OIZG-1126-SM-2HMIU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.999613 GSE158715_3_v_0_cyp1b1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE242290_1_v_11_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-NPJ8-0526-SM-3MJHN GTEx Tissue Sample Gene Expression Profiles 1.0 1.00723 Weight Loss CTD Gene-Disease Associations 1.0 1.14438 IHH-4 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.03979 H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 1083_NEPRO_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.829736 hsa-miR-204 TargetScan Predicted Conserved microRNA Targets 1.0 0.265648 GSE233679_14_v_9_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null layer 2 of AOV cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21675 cytoplasmic membrane-bounded vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.058556 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7918-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ME-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.925777 POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial part of arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.14379 ILK_activemutant_78_GSE25729 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.62476 BUB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29861 anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.18452 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.29032 G120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.934879 Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 testis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.71636 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ABCC2 Pathway Commons Protein-Protein Interactions 1.0 null urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.74374 Cervical carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.836842 hsa-miR-548d-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R55D-0126-SM-48FEL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09507 GSE210655_3_v_5_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE116930,GSE116935_3_v_0_hes7_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XQ3S-0006-SM-4BOQ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50501 GTEX-RN64-1826-SM-48FDV GTEx Tissue Sample Gene Expression Profiles -1.0 -2.44307 Perturb_2698_KD_EXOSC8_ERP005739 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 entorhinal cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36804 H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VJYA-1426-SM-4KL1Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30239 YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE126345_9_v_10_hcrt_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC2263127-pone.0001816.s001.xls-E2F3_up_Bild-Symbol_E2F3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S4Z8-1926-SM-3K2AR GTEx Tissue Sample Gene Expression Profiles 1.0 0.853245 PMC9795333-mmc4.xlsx-HUES66_Ex_SATB2_c1_c4_c9-X-linked_genes_SATB2 Rummagene Transcription Factor Associations 2026 1.0 null 6795_PRPF38B_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.532275 intermediate stratum of RMa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12494 medial vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.41129 paraventricular nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01746 H3K4me1_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-5423-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral hypothalamic area, anterior part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1043 RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LIN7C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07604 GSE195743_1_v_4_lhx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CCNJL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4475 MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR3C1 ENCODE Transcription Factor Targets 1.0 null SH10TC CCLE Cell Line Gene Expression Profiles -1.0 -1.74942 GSE80182_2_v_1_prmt5_human RummaGEO Gene Perturbation Signatures -1.0 null ventrolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1073 H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.951634 CTCF_WI38_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MCF-7_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pparg::Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.5032 GTEX-V1D1-0526-SM-4JBGW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.921174 GTEX-S7PM-0626-SM-4AD4Q GTEx Tissue Sample Gene Expression Profiles -1.0 -2.42396 YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer 1 of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37702 RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEPG2_LIVER CCLE Cell Line Proteomics 1.0 2.77602 Nicalin-NOMO complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.517 SP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.49899 Achromatopsia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.309 ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EJM CCLE Cell Line Gene Expression Profiles 1.0 1.92168 KAT2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null endosome membrane GO Cellular Component Annotations 2015 1.0 null GTEX-RVPU-0011-R9A-SM-3NM8E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.903397 GSE158834_12_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null JUND-26020271-HCASMC-HUMAN-CORONARYARTERY ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Intrinsic component of organelle membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.717 MYO18A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00514 VDAC2 Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_12_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Primary somatosensory area, lower limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43478 NELFE ENCODE Transcription Factor Targets 1.0 null GTEX-SJXC-1226-SM-4DM78 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.73723 ETV5::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.0176 GTEX-S33H-0126-SM-4AD62 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10618 blast cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.101473 retromammillary area, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12426 interleukin-9 receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.621 supraoptic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.18646 GSE120612_7_v_0_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null golgi-associated vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.588456 H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RTLS-0006-SM-2TF58 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824058 KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.92981 mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.07364 Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JR DepMap CRISPR Gene Dependency 1.0 2.32771 RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RUSQ-1926-SM-2TF6K GTEx Tissue Sample Gene Expression Profiles 1.0 1.46861 POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 NCI-H1648 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.13788 Integral component of organelle membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null subcallosal cingulate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.931376 GSE131425_2_v_0_arg2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XMD1-0011-R11A-SM-4AT5J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3398 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X4XY-0626-SM-4E3IN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.892311 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Anteromedial visual area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22512 GSE103068_0_v_3_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null eed_20123906_mouse_embryonic_stem_cell_lof_mouse_gpl1261_gse19076 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.149924 H2BC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15583 GSE147240_0_v_2_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null Intracellular vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 hsa-miR-1276 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_2164_KD_Chd8_SRP062904 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -11.8026 TAF1_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NTRK3_drugactivation_67_GSE20358 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.36498 cellular_component GO Cellular Component Annotations 2015 1.0 null FOS::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3478 GSE227592_4_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0727 H3K4me1_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19223 CTCF_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4 ENCODE Transcription Factor Targets 1.0 null GSE245134_0_v_1_atg5_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE100732,GSE100733_0_v_1_lrpprc_mouse RummaGEO Gene Perturbation Signatures -1.0 null midbrain raphe nuclei Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.905651 CTCF_retinal pigment epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-W5X1-2326-SM-3GIL6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.3445 hsa-miR-548a-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.37496 hsa-miR-892b TargetScan Predicted Conserved microRNA Targets 1.0 0.348832 fertilizedegg BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.914413 GSE204832_0_v_1_imiquimod_mouse RummaGEO Drug Perturbation Signatures -1.0 null Perturb_2806_KD_TINCR_SRP180203 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 RUNX2 ChEA Transcription Factor Targets 1.0 null TCF7L2_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.866203 IRF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.6667 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5ZF-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-577 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GSE142588_2_v_0_cinobufagin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE158715_2_v_4_cyp1b1_mouse RummaGEO Gene Perturbation Signatures 1.0 null bounding membrane of organelle GO Cellular Component Annotations 2015 1.0 null GSE242290_1_v_0_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CAMA-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.93 GTEX-XMK1-0005-SM-4B665 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.909003 CTCF_GM12867_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Folic Acid CTD Gene-Chemical Interactions 1.0 null GTEX-WOFM-1726-SM-3MJFA GTEx Tissue Sample Gene Expression Profiles 1.0 1.56632 Perturb_15969_KO_Gata3_SRP357829 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.77235 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OZ-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Primary somatosensory area, barrel field, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20359 hsa-miR-576-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 SH4 CCLE Cell Line Gene CNV Profiles -1.0 -1.33192 5809_NRBP1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.598118 HDAC1 ENCODE Transcription Factor Targets 1.0 null lateral mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.94433 H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mediodorsal nucleus of thalamus_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.09546 Sarcoma_SARC_TCGA-DX-A6BA-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16232 H3K4me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null amygdaloid complex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04182 Brain Lower Grade Glioma_LGG_TCGA-CS-5396-01A-02R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.91665 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1IC-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE124375_13_v_0_chd2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Posterior parietal association areas, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11309 GTEX-XQ8I-0326-SM-4BOPN GTEx Tissue Sample Gene Expression Profiles 1.0 0.874484 Brain Lower Grade Glioma_LGG_TCGA-DU-7300-01A-21R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-DX-A6YQ-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6474-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Golgi-associated vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.114 superficial stratum of ERCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36713 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5442-01A-01R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of the aortic adventitia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFON-2526-SM-3LK7P GTEx Tissue Sample Gene Expression Profiles 1.0 0.949865 GTEX-T8EM-0126-SM-4DM5R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26934 HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.846928 BMI1-19503595-MEFSC-MOUSE ChEA Transcription Factor Targets 2022 1.0 null primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.13233 JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.828336 ETV2::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.9934 TrigeminalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.00631 head TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 ventrolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.66108 IGR1 CCLE Cell Line Gene CNV Profiles -1.0 -1.72945 GSE179002_2_v_7_caprin1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-PSDG-0526-SM-2S1OH GTEx Tissue Sample Gene Expression Profiles 1.0 1.39822 PMC9314667-Table_1.xlsx-Regulons-ATF5_ATF5 Rummagene Transcription Factor Associations 2026 1.0 null BHT101 CCLE Cell Line Gene CNV Profiles 1.0 1.79086 CTCF_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-548e TargetScan Predicted Conserved microRNA Targets 1.0 0.419947 GSE151090_2_v_4_verteporfin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE193993_1_v_3_sstr2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-SUCS-1426-SM-4DM5W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.843434 Testis GTEx Tissue Gene Expression Profiles 2023 1.0 1.67312 MKN-45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.970428 ELK4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P78B-1326-SM-3P611 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92923 H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KLF4 JASPAR Predicted Transcription Factor Targets 1.0 null IZ in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00756 GSE126345_4_v_5_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null 13_AARS_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.514519 GSE115363_2_v_4_esrrb_mouse RummaGEO Gene Perturbation Signatures 1.0 null Subgeniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.92026 H3K79me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TEAD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE226285_3_v_0_nr0b1_human RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-3660 TargetScan Predicted Conserved microRNA Targets 1.0 0.199275 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05247 GTEX-R3RS-0005-SM-3GAEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.87072 adrenal gland GTEx Tissue Gene Expression Profiles -1.0 -0.968329 H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null Nucleus of reunions Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10067 primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.88682 perimammillary part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29141 STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151090_5_v_4_verteporfin_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRF_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1 ENCODE Transcription Factor Targets 1.0 null Hereditary spastic paraplegia 6 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.485 H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null SUDHL10 CCLE Cell Line Gene Expression Profiles 1.0 1.57302 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I2-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null S107 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.24 Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.055 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041219 GSE197630_1_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null A3KAW CCLE Cell Line Gene CNV Profiles -1.0 -1.51851 IZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.2448 organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Intermediodorsal nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34633 myeloid progenitor cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.109819 MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ID4_KO_GDS4178_620_mouse_Splenic B cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-TMMY-1326-SM-4DXU9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.861966 NCI-H1373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.888433 GE-47-OO30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.326751 ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.967888 HCC827 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.875315 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5989-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PA-TU-8988S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11013 Lung adenocarcinoma_LUAD_TCGA-05-4244-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of skin of abdomen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.861567 ventral tuberomammillary nucleus, superficial part (histaminergic) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.98127 SMC3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VJWN-0626-SM-3NMAN GTEx Tissue Sample Gene Expression Profiles 1.0 0.964315 RS4-11 COSMIC Cell Line Gene Mutation Profiles 1.0 null PAQR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02771 H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE247084,GSE247087_0_v_1_cdyl_human RummaGEO Gene Perturbation Signatures -1.0 null PSMG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11595 STAT3 ENCODE Transcription Factor Targets 1.0 null CTCF_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7245-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S32W-2426-SM-2XCAT GTEx Tissue Sample Gene Expression Profiles 1.0 1.37973 SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01756 GTEX-Q2AI-0008-SM-48U2H GTEx Tissue Sample Gene Expression Profiles 1.0 0.94379 20220088-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SNU-719 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -3.82124 BT549 CCLE Cell Line Gene Expression Profiles 1.0 1.35505 primary auditory cortex (core)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.867096 GTEX-SJXC-0426-SM-2XCFH GTEx Tissue Sample Gene Expression Profiles 1.0 1.2598 layer 1 of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38533 T-47D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.828336 RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null TM9SF2 Pathway Commons Protein-Protein Interactions 1.0 null thyroid_5b HPA Tissue Sample Gene Expression Profiles 1.0 0.824164 organelle LOCATE Predicted Protein Localization Annotations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-O2-A5IB-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.967888 GTEX-U3ZN-0426-SM-4DXSH GTEx Tissue Sample Gene Expression Profiles 1.0 1.36033 OPM2 CCLE Cell Line Gene Expression Profiles 1.0 1.70098 GSE227592_8_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null GSE195582_0_v_1_pim1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null testis_7e HPA Tissue Sample Gene Expression Profiles -1.0 -2.32078 GTEX-OHPL-0426-SM-3TW8X GTEx Tissue Sample Gene Expression Profiles 1.0 0.891957 GSE242199_9_v_5_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null NB4 DepMap CRISPR Gene Dependency 1.0 2.43978 lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.55641 EP300_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE103068_0_v_4_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-FV-A2QR-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P4QT-1826-SM-2S1NJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.34278 CTCF_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REH Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.2254 episupraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.032 GSE120370_4_v_1_thrombin_mouse RummaGEO Drug Perturbation Signatures -1.0 null TCF12 ENCODE Transcription Factor Targets 1.0 null H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K79me2_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XBEC-0126-SM-4GIDT GTEx Tissue Sample Gene Expression Profiles -1.0 -2.24073 r7 part of trigeminal transition zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46826 496100590_FWM_probable Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.17803 Mediodorsal nucleus of the thalamus, central part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04524 septal organ BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.0835 H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null primary motor cortex (area M1, area 4)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.36274 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ATF2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-548ae TargetScan Predicted Conserved microRNA Targets 1.0 0.274552 EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null P53-21459846-SAOS-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-TML8-2026-SM-32QOP GTEx Tissue Sample Gene Expression Profiles 1.0 0.916039 HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.17557 spinal cord TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.076458 EJM DepMap CRISPR Gene Dependency 1.0 2.21018 H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null outer SZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.11834 CREB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null