association	dataset	threshold value	standardized value
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22429
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2742
EMD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79507
BRD-K75772626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31477
RPL38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39621
NR2F6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K17743313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76305
esophagus	HPA Tissue Gene Expression Profiles	-1.0	-0.894173
BRD-K91191855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36812
MONOMAC6	Achilles Cell Line Gene Essentiality Profiles	1.0	1.12968
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.566821
G3BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3421
SMAD4-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K72915114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73565
MOLT4	BioGPS Cell Line Gene Expression Profiles	1.0	0.980842
GSE199541_2_v_5_mbd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D1_1084_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PGBD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05637
BRD-K79887921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67585
NOL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54545
GTEX-QVJO-0011-R1A-SM-2S1QI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38462
BRD-K50114736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59869
GSE195559_6_v_5_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K88362336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22306
RBPJL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72889
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.951252
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.06945
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.29591
GSE198228,GSE198245_0_v_2_apoe_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNU503	CCLE Cell Line Gene Expression Profiles	1.0	2.20932
CRCGN015_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6329
Adrenocortical carcinoma_ACC_TCGA-OR-A5J5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CNNM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88842
SW620	BioGPS Cell Line Gene Expression Profiles	1.0	1.43209
Prostate adenocarcinoma_PRAD_TCGA-G9-6498-01A-12R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAPAN1	DepMap CRISPR Gene Dependency	1.0	8.57923
Occipital pole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.656
PPP1CC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38576
PRDX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4375
CPSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25078
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K14499901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24152
Brain Lower Grade Glioma_LGG_TCGA-HT-A5R7-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-V1-A8WN-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LENG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4806
AOC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0174
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.851452
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
CRCGN009_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81938
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RBM41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50207
ChIP_REST_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K78960724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06836
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
RCOR3-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-6770-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142684_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DTX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35826
BMI1-19503595-MEFSC-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CHP134	DepMap CRISPR Gene Dependency	1.0	2.12056
H3K27me3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_SOX9_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
FOXH1-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K66865641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20736
IFT20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02994
GTEX-T5JC-0011-R2A-SM-32PLZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850599
ZNF655	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.057
C2CD4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32719
Phosphatidylinositol 3-kinase complex, class I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.673
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.833311
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3266
GSE205163,GSE205164_3_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.09925
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TP53_DEPLETION_GDS4070_451_human_MDA-MB-231 breast cancer cells (depleted of MUTANT-p53)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.899286
CRCGN017_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.58225
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.0717
CLDND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.9804
HDLM2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32848
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66684
mbl2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.841
PMC6299095-41389_2018_108_MOESM4_ESM.xlsx-T47D-TRPS1_peak-gene_symbol_TRPS1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4228
Sarcoma_SARC_TCGA-DX-A7ER-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
liver_c	HPA Tissue Sample Gene Expression Profiles	1.0	0.99449
NCIH2110	DepMap CRISPR Gene Dependency	1.0	2.61124
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01727
Kidney Chromophobe_KICH_TCGA-KN-8425-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95153427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18081
Lung squamous cell carcinoma_LUSC_TCGA-J1-A4AH-01A-31R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nuclear type mitochondrial complex I deficiency 33	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.857
CRCGN009_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5284
MZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.827146
H3K27me3_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NDUFA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.54843
MDA-MB-453	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01727
TP63	ChEA Transcription Factor Targets	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.63954
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TC-YIK	GDSC Cell Line Gene Expression Profiles	1.0	1.76398
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CZIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46551
SOGA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68817
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_MSC_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
hippocampus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.334865
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	6.35332
Prdm14	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.1126
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16027
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.16178
C19orf44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45641
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77497
LYPD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32926
ventral posterior inferior nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25385
Natural killer CD56 bright cell_Stomach_Human	CellMarker Gene-Cell Type Associations	1.0	null
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.09934
PMC7594423-12915_2020_895_MOESM13_ESM.xlsx-Table_S6C-Table_S6C_-_Differentially_Expressed_genes_shared_between_BRCA_TRIM25_amp_and_PRAD_CIC_Del_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K94273044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03309
RNF114	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11493
CRCGN008_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.223
MPND	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.1597
BRD-K43848904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15552
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.890696
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33346
GMIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43057
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20012
metabolic process	GO Biological Process Annotations 2015	1.0	null
Puncta adhaerentia	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.284
SKMEL24	CCLE Cell Line Gene Expression Profiles	-1.0	-2.1396
LMAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57896
SW900	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATAD3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.45112
BRD-K49733809	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19663
Acute Myeloid Leukemia_LAML_TCGA-AB-3000-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYBL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66584
hsa-miR-1260	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8342
ChIP_H3K27me3_17603471_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CRCGN015_MCF10A_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.68013
abnormality of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.106569
BRD-K54686062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49792
GSE138818_2_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UBE2G1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88327
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5KH-06A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.85811
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852252
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
wt1_17420277_e11dot5_urogenital_ridge_lof_mouse_gpl1524_gds2747	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.2625
IC-05-AW29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.35237
LCLC103H	CCLE Cell Line Gene CNV Profiles	-1.0	-2.09127
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01480	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.942718
GSE214382,GSE214383_1_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OXRO-0011-R10A-SM-2I5EH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15327
striatum_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.863842
brain_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.37045
Prostate adenocarcinoma_PRAD_TCGA-HC-7821-01A-12R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A12830281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40343
PMC9170821-JCMM-26-3183-s001.xlsx-Neu_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
KHSRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.98099
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.980077
Perturb_8475_KO_CTNNB1_SRP137216	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.62076
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63149
SARS-CoV MA15_Day4-PFU-10^2_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.826182
FAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45107
Erythrocyte Count	dbGAP Gene-Trait Associations	1.0	0.089611
GTEX-XGQ4-2026-SM-4AT6G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887097
BRD-K12111274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23491
GSE234289_4_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7694-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO679	CCLE Cell Line Gene CNV Profiles	1.0	1.35654
CUX1-19635798-MULTIPLE HUMAN CANCER CELL TYPES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UMPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68193
RNF214	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82647
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.75005
PRMT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41109
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3597
NADK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43551
Spleen	GTEx Tissue Gene Expression Profiles 2023	1.0	1.1822
MARF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21281
posteroventral (inferior) parietal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.935268
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SH3BGRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.45716
CDX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29339
Embryonic structure	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.169
CRCGN015_MCF10A.TP53.M_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.41944
HS 578T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.835533
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-SYMBOL_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
FAAP24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90451
BRD-K12640996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80973
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067018
mRNA_ZSCAN4C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K69466030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07288
SLC66A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50461
BRD-K62965224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02828
GTEX-NPJ8-0011-R6a-SM-2HMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83829
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10707
hsa-miR-3135	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE223008_9_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A5U8-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K14602451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45849
TP53-23651856-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-0011-R10A-SM-3GIK3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27908
C8166	DepMap CRISPR Gene Dependency	1.0	3.53219
BRD-K96023136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09
MRPS14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83496
nucleolus-like body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.199
GSE211931_2_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.986967
BRD-K48755012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3035
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.970778
BRD-K82774801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07995
ANAPC15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91092
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998112
GSE242199_9_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K82506716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03403
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A898-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04405
ITGA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97667
PMC11801220-NIHMS2038999-supplement-16.xlsx-Exc-MAF-gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03448
PMC7064337-elife-51373-supp1.xlsx-MTF2_targets_shCTR-List_of_2011_genes_marked_by_MTF2_ChIPseq_in_control_conditions_shCTR_MTF2	Rummagene Transcription Factor Associations 2026	1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.927914
Nuclear type mitochondrial complex I deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.204
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.03359
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7475
NDUFB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75053
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.248153
Daoy	GDSC Cell Line Gene Expression Profiles	-1.0	-1.46786
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44295
OSGIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8505
TE10	CCLE Cell Line Gene CNV Profiles	1.0	2.54069
SNU13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75074
BRD-K99971319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4983
GSE127790_9_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
D-566MG	GDSC Cell Line Gene Expression Profiles	-1.0	-1.58739
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94896
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
RENT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.878
GP1BA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40299
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889974
SC5D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44441
OVKATE	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46112
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07813
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03185
GSE151829,GSE151831_5_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MN-60	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SLC43A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9237
i10	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.899
BRD-K22069962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54889
artery disease	GWASdb SNP-Disease Associations	1.0	0.117888
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_MAP_AA-GENE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34693
disease	GWASdb SNP-Disease Associations	1.0	0.037812
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.54109
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-2964a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.175726
NCIH1568	CCLE Cell Line Gene Expression Profiles	-1.0	-1.97956
SKM-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.52782
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE144919,GSE145177_1_v_0_dazl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCDC137	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14649
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.57872
PJA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30598
NCIH209	CCLE Cell Line Gene Expression Profiles	1.0	1.64115
GSE173873_10_v_13_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NPJ8-0011-R9a-SM-2YUN5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85899
RIPK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42152
GNPTG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34646
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NQO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34567
GSE244710_3_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193351_1_v_3_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSK3A_KD_GDS4305_180_human_MOLM-14 myeloid leukemia cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-N7MS-0011-R4a-SM-2HMKW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01292
BRD-K14470344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31145
inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.973067
cerebral cortical neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.796874
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K65137277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19639
H1 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.48141
BRD-K49409924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19093
BRD-K86232198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01121
liver_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.1488
SNU601	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21044
PMC11801220-NIHMS2038999-supplement-14.xlsx-Exc-MAF-gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
ARHGAP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35219
brain	GTEx Tissue Gene Expression Profiles	1.0	1.31999
GTEX-PWO3-0011-R1A-SM-2I5EW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01033
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MDM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10934
H3K27me3_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20598
PLEKHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65385
cortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46784
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.3308
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.259
KMS20	DepMap CRISPR Gene Dependency	1.0	2.28065
FASTKD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64273
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27106
BNC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.87544
DPH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23643
BRD-K83898323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15081
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3669
BRD-K10696228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17347
RAB17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71296
Perturb_5768_KO_Sip1/Nkx21_SRP010804	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
primary motor-sensory cortex (samples)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.997484
BRD-K61924932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45076
CAMK2N1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4047
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.29844
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.854201
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
EFO-21	GDSC Cell Line Gene Expression Profiles	-1.0	-1.63598
MZT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74508
SKNO1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.32148
GTEX-XLM4-3026-SM-4AT6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46609
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04892
H1-7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61138
S100A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34179
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06179
BRD-K62833556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10332
PECAPJ41CLONED2	CCLE Cell Line Gene Expression Profiles	1.0	1.42384
USP35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51316
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7589-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-QQ-A8VB-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3918	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.959223
BRD-K05251963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00249
TTNPB-451	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CALB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42463
HCC1171	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53139
MICU2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83329
smarcc2_00000000_e12dot5_embryonic_cortex_lof_mouse_gpl6887_gse45629	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.033819
NCIH1573	CCLE Cell Line Gene Expression Profiles	1.0	1.42948
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Gimen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.798
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76822
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
YME1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10654
F12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67726
Cornu ammonis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.106
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5F-Up_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K67118623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04811
CA1 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.22854
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE230744,GSE237803_0_v_2_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
POU2F1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
MYC-19915707-AK7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE145915_0_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA_POU5F1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-P44H-0011-R10A-SM-2XCEK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32551
BRD-K70886325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21598
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.943108
M14	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9999
MHH-PREB-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83754
SRY	ChEA Transcription Factor Targets	1.0	null
GSE111660_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52475
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5364
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16378
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10X-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE145249_1_v_3_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.927914
LSM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68111
OVTOKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.851452
DMXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12007
GTEX-NPJ8-0011-R3a-SM-2HMIW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09354
496100572_HIP_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.58858
immune system disease	GWASdb SNP-Disease Associations	1.0	0.054285
Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66717
Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K53326976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18801
BRD-K88538240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47362
RCOR3	ChEA Transcription Factor Targets	1.0	null
lung cancer	GWASdb SNP-Disease Associations	1.0	0.607188
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.004
LGALS3BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71725
GTEX-WHSE-0011-R2A-SM-3P5ZL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00587
NMRK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09183
NCIH1563	CCLE Cell Line Gene Expression Profiles	-1.0	-2.47888
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.76135
ZNF711	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51652
GSE249714_0_v_1_anxa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE245270_1_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11801220-NIHMS2038999-supplement-15.xlsx-Exc-MAF-gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47555438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38524
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_34_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73969016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49333
EEF1B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47438
GSE101239_5_v_1_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU1079	DepMap CRISPR Gene Dependency	1.0	2.76537
BLCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04622
ZNF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25781
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.51531
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81136
Perturb_14224_KO_Tcf12_SRP392331	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.10998
GSE142684_0_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160293_2_v_4_celf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RPAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97547
Antennal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.087
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18344
icSARA deltaORF6_0Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.5409
REST-18959480-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
PMC2883591-pgen.1000979.s003.xls-NRSF_GENELISTS_WitOut_GeneSig_g-Supplemental_Table_3_REST	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X4XX-0011-R3B-SM-46MWK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56007
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2904-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Chronic Periodontitis	DisGeNET Gene-Disease Associations	1.0	null
BRD-K94476572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54186
BRD-K10459843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70722
BRD-K63757709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83092
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K42966513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30934
PMC7793767-Table_2.docx-0-Upregulated_genes_in_the_pancreas_of_AA_vs_controls_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.866558
spleen	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.928641
BRD-K86285108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08134
GSE158197_0_v_11_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CLSPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45041
Brain Lower Grade Glioma_LGG_TCGA-DB-5270-01A-02R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE224131_5_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_10312_OE_hAPOL1_G1_SRP075245	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Rotavirus infection of children_Peripheral blood mononuclear cell_GSE2729	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.51108
GSE109140_2_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARIH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58828
USP21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27894
GRB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87843
GSE126345_2_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NAXD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00471
HDAC6	ENCODE Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7874-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X585-3026-SM-46MWF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52083
ChIP_H3K9me3_19884255_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
TC32	CCLE Cell Line Gene Expression Profiles	1.0	1.72743
SP1	JASPAR Predicted Transcription Factor Targets	1.0	null
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.29397
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8328
dorsal thalamus_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.879557
LAMA-84	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.83674
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052975
NB6	DepMap CRISPR Gene Dependency	1.0	2.05278
COLO678	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66018
abnormality of blood and blood-forming tissues	GWASdb SNP-Phenotype Associations	1.0	0.615351
JHH-7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
skeletalmuscle	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00939
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59441
hsa-miR-3135b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.55901
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NDUFAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27963
hsa-miR-4419a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1567
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEIS1_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
SZRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87366
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.997484
LNZTA3WT4	DepMap CRISPR Gene Dependency	1.0	2.11105
monorden-544	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60035
CRCGN015_HEPG2_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.335
MECP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01327
MANSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00812
C10	DepMap CRISPR Gene Dependency	1.0	2.10454
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65439
U-87-MG	GDSC Cell Line Gene Expression Profiles	-1.0	-1.65255
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Endocytic vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.021
NCIH69	CCLE Cell Line Gene Expression Profiles	1.0	1.86494
GTEX-X585-0011-R4B-SM-46MVH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0953
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EH-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13564884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11302
CNN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53405
organ system cancer	GWASdb SNP-Disease Associations	1.0	0.040382
GSE137177_2_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SFXN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62874
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.886241
GSE118794_2_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133070_2_v_4_prss1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RNOR-0011-R9A-SM-2TF52	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906093
EKVX	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.21573
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.4874
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NV-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WM2664	DepMap CRISPR Gene Dependency	1.0	2.3221
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SK-01B-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STEAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79738
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857916
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-A02612852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19696
POLR3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7035
POLR3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7805
Necrosis	CTD Gene-Disease Associations	1.0	1.04831
CL11	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39066
ESR1-22446102-UTERUS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MTX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5489
BRD-K50240676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07381
CRCGN017_MCF10A.TP53.M_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45277
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SP-01B-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-58-8390-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8128-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPP1	Pathway Commons Protein-Protein Interactions	1.0	null
EGR1	ChEA Transcription Factor Targets	1.0	null
HCC1419	GDSC Cell Line Gene Expression Profiles	1.0	1.6626
647-V	GDSC Cell Line Gene Expression Profiles	-1.0	-1.46691
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054333
GSE101239_4_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.907938
XRCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98288
NANOG	ChEA Transcription Factor Targets	1.0	null
CRCGN009_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.38654
VCAP	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.32234
NANOG-16518401-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ESR1	ChEA Transcription Factor Targets	1.0	null
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.47881
HNF4	MotifMap Predicted Transcription Factor Targets	1.0	null
Fetalbrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.835533
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	1.0	4.63284
MYC	ChEA Transcription Factor Targets	1.0	null
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27874
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE180185_9_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
OLFM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48913
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
brain	HPA Tissue Gene Expression Profiles	1.0	1.86449
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52253
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.84839
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.5304
CRCGN010_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.14225
inferior nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.41288
GTEX-X4XX-0011-R2A-SM-3P623	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899446
Brain Lower Grade Glioma_LGG_TCGA-HT-7856-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K82528406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16301
ZW10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23988
DCAF12L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10778
DCP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93483
hsa-miR-3944-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-K30326216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22447
tanespimycin-450	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NA-A5I1-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KIF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.64892
GSE223008_7_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8620-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.69071
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-6028-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2814	Achilles Cell Line Gene Essentiality Profiles	1.0	1.97196
MSN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21758
TGFBR2_knockout_295_GSE45968	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.71632
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.5264
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	1.77479
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.914531
lateral dorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.844297
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.979869
NB1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57963
SLR21	CCLE Cell Line Gene Expression Profiles	1.0	1.72276
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01549	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.18568
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K75904236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58827
NSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19492
RNF40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00259
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09233
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.913311
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.50201
GSE211931_0_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K85972696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0102
abnormality of the lung	GWASdb SNP-Phenotype Associations	1.0	0.134611
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
496100391_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.29455
DNAJC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47444
CREB1	ChEA Transcription Factor Targets	1.0	null
ANLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58428
Sexual health disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.279
hsa-miR-4645-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01634
SEPHS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78932
ZNF879	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19066
GSE172020_0_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050731
TE10	Achilles Cell Line Gene Essentiality Profiles	1.0	1.10543
PCDH10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10759
FAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97908
H3K27me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HS852T	CCLE Cell Line Gene Expression Profiles	-1.0	-2.04287
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856084
GSE87615_2_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A656-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-5643-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
TMEM145	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.764
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5424
VPS39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98919
cerebellar cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.5889
CTSL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23393
OC-314	GDSC Cell Line Gene Expression Profiles	-1.0	-1.57704
CREB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07977
RABIF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07103
PMC6145927-41467_2018_5729_MOESM6_ESM.xlsx-TF_Activity_Genesets-FRA1_UP_FOSL1	Rummagene Transcription Factor Associations 2026	1.0	null
PDCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27392
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D1_1591_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142684_4_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.98629
LAMB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33906
JHH2	CCLE Cell Line Gene CNV Profiles	1.0	2.15538
BRD-K65183353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32424
H3K9me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MARVELD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50877
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.4253
prepositus hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.836046
OCT4-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GAMG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59128
BRD-K60255752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29436
KDM4A	ENCODE Transcription Factor Targets	1.0	null
DU145	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.15673
GSE217541,GSE217543_3_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DPRX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37452
GSE118794_5_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K97106314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16375
NCI-H250	COSMIC Cell Line Gene Mutation Profiles	1.0	null
17344918-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GTEX-WHSE-0011-R4A-SM-3P5ZN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963239
Kidney Chromophobe_KICH_TCGA-KN-8431-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.62955
outer CP in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01634
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
imatinib_homo sapiens_gpl96_gds3045	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ABRACL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32966
RVH421	CCLE Cell Line Gene CNV Profiles	1.0	1.99298
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.459
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.6775
CTCFL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.74749
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
LAN2	DepMap CRISPR Gene Dependency	1.0	4.42532
GSE87615_1_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
C32	CCLE Cell Line Gene CNV Profiles	1.0	1.41975
GSE140607_1_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
PMC8500868-401_2021_2354_MOESM5_ESM.xlsx-GEP_PATZ1-Gene_Symbol_PATZ1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QMR6-1426-SM-32PLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36304
Sarcoma_SARC_TCGA-PC-A5DN-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211286_7_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.938292
BRD-K13817284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12614
CRCGN015_HEPG2_48H:E22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48483
SOX9	ChEA Transcription Factor Targets	1.0	null
CRCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81753
mRNA_T_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
hyoscyamine-1424	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.824803
SNRNP40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69059
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53809
TMEM259	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5877
PPIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25457
GSE186440,GSE186443_3_v_7_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VP-A87B-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STRADB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46779
BRD-K64509887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45285
PDGF_ERK_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.09648
Lung squamous cell carcinoma_LUSC_TCGA-98-A53A-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE248659_1_v_0_klf5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205976,GSE205978_1_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0225
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4105
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81282
Brain Lower Grade Glioma_LGG_TCGA-HT-7880-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-M7-A71Z-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_S7C-GENE_LIST_UPLOADED_TO_ENRICHR_MAX_KO_TESTES_627_GENES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE196104,GSE196106_2_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71463
LS	DepMap CRISPR Gene Dependency	1.0	2.90493
GSE206870,GSE206872_1_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
copper sulfate-438	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.044968
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-0.894173
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9538
mediodorsal nucleus of thalamus_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.889321
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-8601-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GM97	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.52692
GSE142684_3_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0238
ICAM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30406
H4K20me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69728
BRD-K35909757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15801
BRD-K02206127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23193
MCF7	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39342
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.78166
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7178
GTEX-X4XY-1626-SM-46MVN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13386
KNDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4555
CRCGN015_MCF10A_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.96705
hematopoietic system disease	GWASdb SNP-Disease Associations	1.0	0.714752
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE111660_2_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
chr22_43419582_G_GC_b38	GTEx eQTL 2025	1.0	1.54842
TSSC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27441
GAPDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39396
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.96538
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34932
ARHGAP23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19076
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
HARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25295
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0
CRCGN008_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26895
CMAH_KO_GDS4770_420_mouse_muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-A40010674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62745
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
BRD-K98637033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49341
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10224
Perturb_8478_KO_PTPN2_SRP077320	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.11579
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39X-11A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NPIPA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50428
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.09528
GSE160373_1_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
CRCGN015_MCF10A.TP53.M_24H:H12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0536
SPAG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05491
MCF-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09876
HEY	DepMap CRISPR Gene Dependency	1.0	2.24408
KATNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04134
ventral posterior lateral nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01268
Lung squamous cell carcinoma_LUSC_TCGA-37-A5EN-01A-21R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K92967681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36898
RARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41922
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.85727
CRCGN014_HEPG2_3H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88612
medial group of nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.864546
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.89634
GATA2_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
aklomide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03989
BRD-K40960913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34115
TE-10	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Calcineurin-like phosphoesterase	InterPro Predicted Protein Domain Annotations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-93-7348-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.36266
H3K27me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE133213_2_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19175
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_5_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.929732
CRCGN017_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.95228
JMJD1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.01058
TOPBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45249
CRCGN017_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06083
RAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.598
DHRS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60279
TE-6	GDSC Cell Line Gene Expression Profiles	1.0	1.8553
SRMS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54682
GTEX-X4XX-3026-SM-3NMB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62371
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.73289
liver_d	HPA Tissue Sample Gene Expression Profiles	1.0	1.13194
HOXD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34278
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-4103-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4510	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GSE153757,GSE153758_1_v_3_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.20628
BRD-K94962552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1016
HMGN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08779
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE224131_2_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE173873_10_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-GRHL1_GRHL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211286_1_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K17583574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01397
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17785
BRD-K06685815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26748
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34932
CRCGN009_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.9313
FTC133	CCLE Cell Line Gene Expression Profiles	-1.0	-3.62799
GTEX-Q2AG-3026-SM-48U1L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889656
BRD-K80332123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35964
GSE172020_1_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-GENE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
SK-N-SH	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.95319
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.965521
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5231-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE138228,GSE138230_2_v_1_cdkn1c_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QMR6-0011-R1A-SM-32PKW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11597
ZBTB7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29905
ATRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02826
GMPPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73792
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4426
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5550-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE94011_0_v_3_pias3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.78881
CRCGN009_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25738
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193351_1_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MITF	ChEA Transcription Factor Targets	1.0	null
GTEX-WZTO-0011-R1B-SM-3NMAR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5295
BRD-K49745710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07828
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.272
VMRCRCZ	CCLE Cell Line Gene CNV Profiles	-1.0	-2.04974
HEC251	CCLE Cell Line Gene CNV Profiles	-1.0	-1.65605
MAP3K10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27375
SKNSH	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58881
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987605
Brain Lower Grade Glioma_LGG_TCGA-HW-7489-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142684_2_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
DNAJB14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21288
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
SRY-22984422-TESTIS-RAT	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
NCI-H526	GDSC Cell Line Gene Expression Profiles	1.0	1.54842
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IR-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kanzaki disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.467
disease of cellular proliferation	GWASdb SNP-Disease Associations	1.0	0.038095
posteroventral (inferior) parietal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24561
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PPARA-22158963-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SPAG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14423
Osteogenesis imperfecta type 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
Brain Lower Grade Glioma_LGG_TCGA-HT-7607-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_EZH2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
EWSR1_KD_GDS4962_466_human_Ewing sarcoma and prostate cancer	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
MGAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8201
SIMA	DepMap CRISPR Gene Dependency	1.0	2.70006
KARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73952
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.41571
LOX-IMVI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.980567
CAL-148	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.79767
HSF1_KD_GDS1733_750_human_HeLa cells - 0 Hour	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-QDT8-0011-R3A-SM-32PKR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25273
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.920913
cerebral lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.269521
Zfp809	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.5742
RAB3GAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88741
SMAD3-30307970-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
WDHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74242
GSE190316,GSE190324_6_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
respiratory system cancer	GWASdb SNP-Disease Associations	1.0	0.261188
SUZ12	ChEA Transcription Factor Targets	1.0	null
BRD-K22353999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13765
BRD-K50068274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03479
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CEBPA_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41N-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ANKRD24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49578
hsa-miR-4256	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65E-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
HAUS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30281
basal ventral medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.52843
BRD-K37929710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16061
GATA3-26560356-CHIP-SEQ-TH1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8E-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_KO_3T3_ONLY_2084_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
Pons	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.848417
Pauciarticular juvenile arthritis_Peripheral blood mononuclear cell_GSE1402	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.4955
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
R3HDM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46643
1321N1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53848
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057041
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.841748
USP32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.69597
OVCAR3	BioGPS Cell Line Gene Expression Profiles	1.0	1.0603
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34932
CRCGN015_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.49539
CB-40-DA30_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.277359
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.49165
EMC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53585
SLC31A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70004
GTEX-QVJO-0011-R4A-SM-2S1QL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25213
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K46985581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03705
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_ALL-GENE_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3486
BRD-K32916996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42832
GSE164884_2_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939262
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06265
CRCGN015_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63252
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3346
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21853
HNF4A	ChEA Transcription Factor Targets	1.0	null
H4C12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20095
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.259
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
parafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885015
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068579
CRCGN010_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80297
SNU840	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.06858
ESR1-22446102-UTERI-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0561
RARB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09236
CRCGN009_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03529
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.98015
SNX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27103
SUZ12-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NR3C2-34362910-WISTARRAT-HIPPOCAMPUS	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K20735575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36158
SLR23	CCLE Cell Line Gene Expression Profiles	1.0	1.52556
MRK-NU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.040071
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.082985
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60104
SFPQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89495
GSE145215_0_v_3_krt13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562	Achilles Cell Line Gene Essentiality Profiles	1.0	1.963
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.01085
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.179
CLIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79511
hsa-miR-4660	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
OS-RC-2	GDSC Cell Line Gene Expression Profiles	1.0	1.51152
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MAP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92043
LRPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38537
RALA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1826
SKRC31	CCLE Cell Line Gene Expression Profiles	1.0	1.55144
MET	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30825
HCC89	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.930074
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-Embryo-Hatchling_1272_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FHIP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53342
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2576
BRD-K05261060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54356
BRD-K06403738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18169
Sarcoma_SARC_TCGA-DX-A7EI-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FAM76B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57997
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92475
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.956566
Acute Myeloid Leukemia_LAML_TCGA-AB-2949-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02631
Sarcoma_SARC_TCGA-K1-A3PO-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.841119
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.52081
REST	ChEA Transcription Factor Targets	1.0	null
BRD-K52989901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35945
C11orf98	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.32548
wortmannin-506	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE126127_5_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COMMD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15643
REDD1_Repression_GDS3558_73_human_Blood Myeloid Cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
hsa-miR-4324	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4713-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BACH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14838
trifluoperazine-421	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K94109423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50153
hsa-miR-4755-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE145915_3_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37625
ChIP_JARID2_20075857	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978095
Organism form	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.169
CRCGN016_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4964
Schindler disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
YAP_OE_GDS3220_32_human_MCF10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K07497357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09534
NR2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.7585
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1133
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18588
POU5F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56327
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.33835
TRIM46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14136
KYSE450	Achilles Cell Line Gene Essentiality Profiles	1.0	2.12117
GSE126345_9_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
neoplasm of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.277318
ESYT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59523
LMBR1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28878
MRPL36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93446
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.13789
LCLC-103H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.91306
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1794
C32	Achilles Cell Line Gene Essentiality Profiles	1.0	1.2131
ZNF419	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93514
NT5C3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95497
Perturb_17226_KO_lincBrn1b_SRP028547	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.07173
BMI1-19503595-MEFC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
abnormality of cardiovascular system physiology	GWASdb SNP-Phenotype Associations	1.0	0.680272
GSE150215_1_v_0_etl4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PSMA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29567
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GU-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.53448
BRD-K57134435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38534
BRD-K21000135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05098
BRD-K82409466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1884
icSARS-Cov_Day4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.89024
TP53-23651856-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K79329532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00795
H3K36me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.904466
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF250	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39614
GSE172458_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PAPSS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29065
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73Q-01A-21R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IB-06-YD91_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.376579
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.92125
15-delta prostaglandin J2-201	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4338-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.920913
RAD21	ENCODE Transcription Factor Targets	1.0	null
MRPL32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37707
PMC3419980-leu201249x2.xls-RUNX1-ETO_siRE_ChIPSeq_peaks_ge-gene_name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
SNU-C5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Itch intensity from mosquito bite adjusted by bite size	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.669897
Prostate adenocarcinoma_PRAD_TCGA-EJ-8468-01A-21R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K84517695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25097
HSPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28655
SUZ12-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
liver	GTEx Tissue Gene Expression Profiles	1.0	1.31664
Calcineurin-like phosphoesterase domain, apaH type	InterPro Predicted Protein Domain Annotations	1.0	null
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16405
WDR82	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43672
BRD-K44779670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0203
neoplasm by anatomical site	GWASdb SNP-Phenotype Associations	1.0	0.046627
BRD-K51106788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55881
BRD-K45134469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51117
JARID2-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6266
BRD-K69872823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42664
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.67693
WAGR syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.454
CRCGN015_HEPG2_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01629
HSPA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91325
POU5F1_01_05	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59889
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6461
EXOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04491
ZBTB7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68411
CRCGN012_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.17662
SNUC4	DepMap CRISPR Gene Dependency	1.0	3.25522
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40767
ONS-76	GDSC Cell Line Gene Expression Profiles	-1.0	-1.70605
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65342
hsa-miR-4673	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GGA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13346
NCIH292	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43649
BRD-K36515664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92538
BRD-K24479270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28944
CRCGN014_HEPG2_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6447
H3K27me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210101,GSE210114_8_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DTWD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44366
Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1915	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53865
GSE143944_2_v_3_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05789358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28426
REST-18959480-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86732
ARF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83908
NCI 460	BioGPS Cell Line Gene Expression Profiles	1.0	1.18825
MDAMB435S	DepMap CRISPR Gene Dependency	1.0	3.38491
UTP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25922
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.20854
SNU410	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78771
H3K9me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
DCAF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26419
CACNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59954
USP6NL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31602
GTEX-Q2AI-1226-SM-48U14	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856545
BRD-A26952628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0074
CUX1	ChEA Transcription Factor Targets	1.0	null
GTEX-P44H-0011-R4A-SM-2XCEW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2539
BRD-K83307202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80191
CRCGN017_MCF10A.TP53.M_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25155
GTEX-QVJO-0011-R2A-SM-2S1QK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63237
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-369-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.51295
SFXN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54205
CRCGN011_HEPG2_24H:I20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20135
H3K27me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-3116	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
cerebellar cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.956769
PCSK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31487
GSE211286_7_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1201
H3K27me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A83W-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN013_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8052
ZNF484	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27163
GSE180185_4_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EZH2_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K41305193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2381
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4638-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:A10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39265
PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MAX_KO_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210580_3_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168587,GSE168752_3_v_1_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.851452
erythrocyte count	GAD Gene-Disease Associations	1.0	null
BRD-K96389533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00985
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.105204
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.920913
BRD-K08489825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06862
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	139.611
KYSE270	CCLE Cell Line Gene Expression Profiles	1.0	1.62208
BRD-K89264608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04805
MRPL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11093
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42222
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.259
INKA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84452
BRD-K31536290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10126
PMC12640707-NIHMS2124006-supplement-Supplemental_tables.xlsx-Supplemental_Table_S5-Supplemental_Table_S5_Genes_commonly_downregulated_in_both_clones_of_ZFX-depleted_HEK293T_cells_in_Ni_et_al_2020_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
DFCI024	CCLE Cell Line Gene Expression Profiles	1.0	2.40887
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04166
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0
USP24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87524
ventral posterior medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.89592
BRD-K44932450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08449
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_MAP_AA-SYMBOL_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
frontalcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.07371
BRCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44454
Kidney Chromophobe_KICH_TCGA-KL-8338-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PGGHG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36625
BRD-K48749255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24299
outer CP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.994887
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K06208179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02755
MELHO	CCLE Cell Line Gene Expression Profiles	-1.0	-1.61801
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.881
LETMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11028
NCIH2030	DepMap CRISPR Gene Dependency	1.0	2.46937
RIMS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36719
NNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.24747
PDPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77849
Kidney renal papillary cell carcinoma_KIRP_TCGA-V9-A7HT-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.03631
GATA1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5697
WDR26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30413
PTPN13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09859
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MELHO	CCLE Cell Line Gene CNV Profiles	1.0	1.43614
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.829184
BRD-K51175229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31728
CRCGN011_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1749
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133070_3_v_1_prss1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K37379978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12315
BRD-K80239721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02274
ZC3HAV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98708
GTEX-NPJ7-2726-SM-2I3FT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30041
GSE212330_1_v_0_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4617-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MK-886-264	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79615
TC-32-HZ53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.578213
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
pi1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.709
abnormal respiratory system morphology	GWASdb SNP-Phenotype Associations	1.0	0.134611
JHH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.887519
FRA10AC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62106
EPB41L5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91821
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46721
CRCGN015_MCF10A_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49831
CADM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59539
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.99731
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NAA35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.52684
placenta	HPA Tissue Gene Expression Profiles	-1.0	-0.894173
TTLL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47942
Brain Lower Grade Glioma_LGG_TCGA-WY-A859-01A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A01403444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17923
hsa-miR-1200	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RPF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85321
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16089
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.945752
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A8-11A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
GSE226316_3_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SEKI	DepMap CRISPR Gene Dependency	1.0	2.89179
BRD-K37014934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27244
GTEX-UTHO-0011-R2A-SM-3GIKC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853753
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.75563
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0268
PCDHB8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23506
Lung adenocarcinoma_LUAD_TCGA-55-5899-01A-11R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MFH-INO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K57586808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01267
ABC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.90999
CRCGN014_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13271
Perturb_10720_KO_Setd2_SRP220107	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.24508
Perturb_15983_KO_Larp7_SRP189392	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.35182
Core mediator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.53
hsa-miR-1254	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
HCT15	DepMap CRISPR Gene Dependency	1.0	3.94855
BRD-K06911479	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74811
PMC12211354-12915_2025_2224_MOESM6_ESM.xlsx-Sheet1-Sheet1_The_source_list_of_zebrafish_Npas4b_targets_from_human_NPAS4_targets_in_CHEA3_database_NPAS4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213442_1_v_0_kpna2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IGR39	Achilles Cell Line Gene Essentiality Profiles	1.0	1.20819
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07192
CAPRIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97813
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	1.0	null
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.97527
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69713
496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.15888
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4827-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC30A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61338
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K07812227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34235
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.7713
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MB-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NHLH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48031
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
SNU5	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83143
NCI-H3122	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K67141726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57039
GSE242521,GSE242522_0_v_1_mettl3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A763-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3696
testis_7a	HPA Tissue Sample Gene Expression Profiles	1.0	0.920817
mediodorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.881548
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7761
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27373
Brain Lower Grade Glioma_LGG_TCGA-HT-7695-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mRNA_SOX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.855136
biological_process	GO Biological Process Annotations 2015	1.0	null
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.889253
CRCGN014_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.90511
GSE153137,GSE153140_2_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MKNK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0734
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-8121-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CISD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78149
BRD-K21180458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01125
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8773
Lung squamous cell carcinoma_LUSC_TCGA-22-4604-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.55805
H3K27me3_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74568359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3772
ventrolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10822
UMRC6	CCLE Cell Line Gene Expression Profiles	1.0	2.12953
limitans nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.989181
Rectal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.414
BRD-K18562847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23584
EWSR1_KD_GDS4962_469_human_Ewing sarcoma and prostate cancer	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K67430561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55116
NANOG-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE247084,GSE247087_0_v_1_cdyl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K86981519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81743
GTF2H5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76924
ZNF280B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65366
hsa-miR-4708-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.072324
Brain Lower Grade Glioma_LGG_TCGA-FG-A713-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A-431	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.851452
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.950838
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.920913
GTEX-NPJ7-0011-R10A-SM-2I3E5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44645
BRD-A76076412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69407
GSE238005_0_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
CDC27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72591
SLC4A1AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99603
Superior temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.389
BMI1	ChEA Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4449
UHO1	DepMap CRISPR Gene Dependency	1.0	2.76945
SNG-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC2263127-pone.0001816.s002.xls-Terms_with_Genes_E2F3_up_Bild-Title_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
ChIP_K27me3_17603471_mouseNPC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE147056_2_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_2_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21477
Cholinergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.947
BRD-K82877426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86004
CHMP4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22219
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88274
H3K27me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.962711
PRPF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49453
B800-820 antenna complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.516
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QY-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPP1R15B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39962
AF-07-LS35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237841
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
BRD-K73095160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08033
primary auditory cortex (core)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13225
NCIH1436	CCLE Cell Line Gene Expression Profiles	1.0	3.08868
GPR89A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46482
SCRN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48062
hsa-miR-2861	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.8331
RFLNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90368
Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN012_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4181
GTEX-X4XX-0011-R1B-SM-3P622	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31403
GSE210101,GSE210114_8_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PGBD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.36879
GTEX-TSE9-0011-R4A-SM-3DB7H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30413
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19605
NCI-H345	GDSC Cell Line Gene Expression Profiles	1.0	1.62439
Neuroepithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.96
CRCGN015_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53225
BRD-K54549319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02749
outer CP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03927
RAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41205
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_RCOR3_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K94855649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1967
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.5717
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16291
GSE146612_1_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MK-886-601	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.979627
GTEX-NL4W-0011-R4a-SM-2I5GZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14888
ZMYM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36393
RCC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60592
OCT4-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NCI-H2135	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K67716105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12378
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2379
LZTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77038
SULT1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11071
BRD-A79248021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28038
GSE142684_2_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XOTO-0011-R1B-SM-4B65C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38127
PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.765838
FGFR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03947
GSE122215,GSE122217_0_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855472
PMC4269325-NIHMS634665-supplement-supp_table4.xls-H3K27me3_TRIM37_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P44H-0011-R1A-SM-3NM8J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65609
Perturb_8474_KO_CTNNB1_SRP137216	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.957
TPD52L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06997
GTEX-NPJ8-0011-R7a-SM-2HMJV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880225
GSE57875_1_v_0_hnrnpl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-8456-01A-21R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE109140_2_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SMOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61324
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.192
INO80B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50345
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081189
BRD-K11566982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4119
MALME 3M	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.947051
SMAD4-21741376-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SL-01B-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10679662-mmc3.xlsx-NC-D5-ZEB2-Mutant-Upregulated-Gene_Symbol_ZEB2	Rummagene Transcription Factor Associations 2026	1.0	null
IOMMLEE	CCLE Cell Line Gene Expression Profiles	1.0	1.61876
tacrolimus-169	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE118794_0_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sarcoma_SARC_TCGA-FX-A8OO-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01147
AGAP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.6201
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059968
KIAA0753	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38255
U251MG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53765
GTEX-XLM4-0011-R4B-SM-4AT5C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979263
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.248153
GTEX-RNOR-2326-SM-2TF4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64241
Liver hepatocellular carcinoma_LIHC_TCGA-BD-A3EP-11A-12R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58739
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27106
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08048
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-Q734-0326-SM-48U15	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855528
TRMT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27532
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-4.35321
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.91326
Brain Lower Grade Glioma_LGG_TCGA-DU-7309-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SENP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25568
type ii diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.482921
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LCLC-103H	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K94346447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05865
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01847
BRD-K53706972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32021
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23999
NFYC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62234
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.851452
hsa-miR-1292	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE224556,GSE224557_6_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GFPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70589
propafenone-1722	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE171837_1_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE180185_9_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K81758631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38948
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64861
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20077
SMAD4	ChEA Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5332-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS852T	DepMap CRISPR Gene Dependency	1.0	3.15253
PMC8260656-41467_2021_24380_MOESM4_ESM.xlsx-ERG_EZH2-ATTENUATED_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4763-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
mRNA_SOX2_17515932	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
RPS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01296
SGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32608
SU-DHL-8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Blood Pressure	dbGAP Gene-Trait Associations	1.0	0.146902
HS936T	CCLE Cell Line Gene Expression Profiles	-1.0	-2.16244
GTEX-XOTO-0011-R9A-SM-4GICI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846033
BRD-K67689282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07615
BRD-K55187504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16268
GSE130690,GSE130692_1_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	9.35049
NOP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.64034
Lung squamous cell carcinoma_LUSC_TCGA-46-6026-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MVK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62731
ATP5MJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.289
HERC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5783
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.40364
CCDC50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35793
CAPAN1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51824
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7507
GSE179002_4_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210101,GSE210114_8_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EIF3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38959
mRNA_ASCL2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.007
GSE101239_5_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRDM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05036
CRCGN008_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.83925
GSE235605,GSE235701_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GALNT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84871
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54525
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CITED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58486
PMC11461876-42003_2024_6975_MOESM3_ESM.xlsx-Supplementary_Data_1-Supplementary_Data_1_Differentially_Expressed_Genes_HSE_THP1_Vs_THP1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_8451_KD_EphA2_SRP237314	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.2683
TMEM263	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88813
Pituitary cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.32286
GSE102870_11_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.71125
FOXO1_KD_GDS2720_477_mouse_LSK	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.980567
CRCGN015_HEPG2_48H:F04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.84399
CCNO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13765
TRAPPC6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.08408
BRD-K94862255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22874
JARID2-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K20505830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42197
CRCGN016_MCF10A.TP53.M_24H:D18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.01283
GSE101239_3_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DE-62-FI29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.32417
VAPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24996
ASAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18934
BRD-K99581286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20681
GTEX-TSE9-0011-R1A-SM-3DB7E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31019
Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6131-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NE-4C cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.231
Lung squamous cell carcinoma_LUSC_TCGA-58-8392-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6251_KO_Dicer_SRP041835	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
IPC-298	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-4533	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
BRD-A10134527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04349
MAPK13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49926
Aniridia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.096
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.036596
iPS-18 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.29178
SCAPER	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27047
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929154
GSE174498,GSE174500_2_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K50423606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35609
GTEX-QDT8-2926-SM-32PKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33581
BRD-K07534805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09383
DNASE2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59763
AFDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39611
BRD-K74918080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97965
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65998
GTEX-X4XX-0011-R4B-SM-46MWL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953935
MRPL27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95651
Conjunctival epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.797
H3K23me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE111660_1_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.33513
TOP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13234
GTEX-V1D1-1926-SM-4JBGX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914359
ZIK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33442
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3414
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5892-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210101,GSE210114_6_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ROCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54959
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.35987
MMP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41682
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07684
PMC11749115-loae020_suppl_Supplementary_Table_S2.xlsx-CHOP-high-gene_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4271336-13041_2014_88_MOESM6_ESM.xlsx-Genes_in_GENE_CARD_MR_or_ID-Gene_Cards_MR_and_ID_genes_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CE-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.22754
BRD-K67022703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65157
Posterior midgut	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.146
VDAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90865
CRCGN011_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2514
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	5.36183
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6992-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06792
Sarcoma_SARC_TCGA-DX-A2IZ-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TOR1AIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43394
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.8711
BRD-K13673722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28751
FYN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25731
CCDC61	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35694
BRD-K01211710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1078
HS578T	CCLE Cell Line Gene CNV Profiles	1.0	1.40796
CRCGN017_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.85395
ZNF251	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09785
ChIP_RNF2_22325148	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2861-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE84922,GSE84924_0_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.23841
SAP30	ENCODE Transcription Factor Targets	1.0	null
MAST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30996
GTEX-N7MT-0011-R2a-SM-2I3GI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869964
Primary T cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.867332
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	143.059
H3K27me3_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68677
TP53	ChEA Transcription Factor Targets	1.0	null
PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S8-DUX4_SpecDMCs-Unnamed_3_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7080-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H4K20me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XMD1-0011-R3B-SM-4AT5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05259
BRD-K11641139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29163
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.3975
GSE126345_7_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZSCAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04002
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH1155	CCLE Cell Line Gene CNV Profiles	1.0	1.38956
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60292
COLO-680N	GDSC Cell Line Gene Expression Profiles	-1.0	-1.46423
CRCGN014_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4984
Lung adenocarcinoma_LUAD_TCGA-91-6840-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Activin AB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.233
STAT6	MotifMap Predicted Transcription Factor Targets	1.0	null
CRCGN015_MCF10A_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.43275
BRD-A23345137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65469
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ESRRG_ESRRG	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08638
SIAH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56138
CAL148	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51392
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8ZZ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDVN-0826-SM-48TZ2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15317
PICALM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82687
rnf2_20805357_megakaryocytic_l8057_lof_mouse_gpl1261_gse33659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.853973
SLC7A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33131
BRD-K86232678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13181
AMMECR1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8697
BRD-K89574562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39737
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JARID2	ChEA Transcription Factor Targets	1.0	null
16397240-SuppTable9	GeneSigDB Published Gene Signatures	1.0	null
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836673
496100281_HIP_probable Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22356
hypertension	GWASdb SNP-Disease Associations	1.0	0.78287
Acute Myeloid Leukemia_LAML_TCGA-AB-2985-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tamoxifen-380	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE246053_4_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203017_0_v_1_irs2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CENPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1632
RMUGS	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.23155
hsa-miR-3689c	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
PARP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.578
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DDX46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14252
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6862
GTEX-N7MT-0011-R4a-SM-2I3G9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87532
BRD-K91189798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62718
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30929
BRD-K66807670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0357
TMEM126A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91048
NALM6	Achilles Cell Line Gene Essentiality Profiles	1.0	1.35897
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X585-0011-R2B-SM-46MVF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939612
posteroventral (inferior) parietal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.899286
SF3A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09014
FHIP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10056
GSE139348,GSE139349_1_v_0_dicer1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.979627
Kidney Chromophobe_KICH_TCGA-KN-8424-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TPI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61168
PTPRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8012
GSE206270_1_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158197_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SKMEL2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43486
Perturb_9041_KO_UTX/JMJD3_SRP158713	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.9177
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3409
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44984
BRD-K03089783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04646
PRC1_BMI_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
BRD-K74817844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12406
FADU	CCLE Cell Line Gene CNV Profiles	1.0	3.2675
CEP290	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96754
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10774
GTEX-Q2AG-0011-R8A-SM-2HMK5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860815
GSE214382,GSE214383_5_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.985754
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80809
COMMD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46374
MDAMB435S	CCLE Cell Line Gene CNV Profiles	1.0	1.7689
ILF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.21798
EJM	DepMap CRISPR Gene Dependency	1.0	10.2594
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14317
GSE143955_1_v_0_ripk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8905236-mmc2.xlsx-Table_S10-Table_S10_Differentially_regulated_genes_in_SPI1_high_vs_low_group_in_CGGA_GBM_dataset_SPI1	Rummagene Transcription Factor Associations 2026	1.0	null
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.71247
KLHL21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68655
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SNUC1	DepMap CRISPR Gene Dependency	1.0	2.67293
CST3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38581
MTF2-20144788-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SCAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29468
Perturb_4136_KD_Grin1_SRP106749	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.72197
GSE223008_4_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SUZ12-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K96549574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57666
Phelan-McDermid syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.345
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8	Rummagene Transcription Factor Associations 2026	1.0	null
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51048
MORF4L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21594
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE122215,GSE122217_5_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34832
MFAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01212
TSPO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23368
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.189996
A253	GDSC Cell Line Gene Expression Profiles	1.0	1.67651
BRD-K33453127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50308
RARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0512
Measles Chicago-1_24Hour_16492729_GSE980	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.84326
hsa-miR-504	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.31517
RAG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30423
OC314	CCLE Cell Line Gene CNV Profiles	-1.0	-2.2837
BRD-K70594121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0958
BRD-K93223696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18972
GTEX-X585-0011-R1B-SM-46MVE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5974
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.133
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.79529
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.918457
Lung squamous cell carcinoma_LUSC_TCGA-63-7023-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-NI-A4U2-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2576
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24795
SUPHD1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6649
SOX2-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3103
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.074083
NCIH1869	CCLE Cell Line Gene CNV Profiles	1.0	1.63493
H3K4me1_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.65562
RIC8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88613
AR-25329375-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PRICKLE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45007
Prostate adenocarcinoma_PRAD_TCGA-HC-8261-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE101239_4_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ADD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14441
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-A06578049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31978
BRD-K06450191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32892
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N8-A56S-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE180200,GSE180201_15_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NR1H4::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9661
hsa-miR-4699-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.95144
GSE126345_4_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ANO6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98517
monorden-493	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K15387690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1268
LARP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18589
PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S9-ZNF384_SpecDMCs-Unnamed_3_ZNF384	Rummagene Transcription Factor Associations 2026	1.0	null
outer CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.902702
BRD-K52859120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18199
GRAMD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66803
ChIP_SUZ12_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K53552465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67877
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055545
GSE226355,GSE226357_1_v_0_ybx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K82249895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77097
hsa-miR-1227	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1641
Liver hepatocellular carcinoma_LIHC_TCGA-UB-AA0V-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.86007
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15853
EIF4EBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94687
GSE138001_2_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4630-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02707
ELOVL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96544
SKA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61101
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19635
BRD-K98194167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0163
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08219
GSE171837_3_v_1_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CERCAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31329
Prostate adenocarcinoma_PRAD_TCGA-J4-A83K-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE111660_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.836882
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80774
BRD-K14889526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68841
BRD-K98535708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1228
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27696
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.40301
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OS-01A-12R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.71172
GSE174701_1_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CCDC34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36176
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.96538
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42724
NOC4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23057
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.7446
BRD-K15591233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01516
ZMYND11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.36324
W-13-643	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20772
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
IGR1	CCLE Cell Line Gene CNV Profiles	1.0	1.75111
GTEX-NL4W-0011-R10A-SM-2I3DY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33572
hsa-miR-4770	TargetScan Predicted Conserved microRNA Targets	1.0	0.062888
LU-134-A	GDSC Cell Line Gene Expression Profiles	1.0	1.86723
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946912
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-T6MN-1226-SM-3NMA5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22692
Skin	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.985734
H3K27me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-O2-A52W-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79432
CRCGN013_HEPG2_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33541
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.965143
GTEX-T5JC-0011-R4A-SM-32PLT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04528
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.66722
u	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.549
neoplasm of the lung	GWASdb SNP-Phenotype Associations	1.0	0.515749
GTEX-UTHO-0011-R1A-SM-3GIJO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866886
ALDH5A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18035
GTEX-NL3H-0011-R4a-SM-2I3GK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829348
ULK1_knockout_197_GSE60778	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.79739
EGFR_OE_GDS1925_167_human_Estrogen receptor (ER) alpha positive MCF-7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K30013099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9275
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.869199
BRD-K58787433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15127
CRCGN012_HEPG2_24H:J21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41147
PMC7576810-41419_2020_3099_MOESM9_ESM.xlsx-MS_analysis_EVI1-WT_vs_EVI1-S43-Unnamed_0_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
KPTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47831
CCDC24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.54679
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
CRELD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15538
ADAM10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08641
HEC1A	Achilles Cell Line Gene Essentiality Profiles	1.0	1.22797
BRD-K13275816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8043
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.920913
BRD-K33066317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02491
GATA1	ChEA Transcription Factor Targets	1.0	null
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.523
MKN1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.0433
irinotecan_rattus norvegicus_gpl1355_gds3466	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OXRN-2426-SM-2I5EQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47065
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.36889
CSK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1456
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10282096-41467_2023_39038_MOESM4_ESM.xlsx-All_genes_Upregulated-ENSG00000177426_TGIF1	Rummagene Transcription Factor Associations 2026	1.0	null
SH4	DepMap CRISPR Gene Dependency	1.0	2.92435
BRD-K66288362	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12932
PGLYRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26584
RALGAPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74559
MTF2	ChEA Transcription Factor Targets	1.0	null
AD-99-SN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232172
BRD-K07350528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18861
GSE164757,GSE164759_1_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126345_11_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4078-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.976718
GSE238005_7_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38537
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58921
BRD-K83775558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09932
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE138019_1_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K17062413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3474
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO741	CCLE Cell Line Gene CNV Profiles	1.0	1.65523
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36485
ICAM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28883
naltrindole-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05767
BRD-K36468214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0404
GSE224294_4_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lek	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.154
EBNA1-20929547-CHIP-SEQ-RAJI-CELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SALE	CCLE Cell Line Gene Expression Profiles	1.0	1.66046
BRD-K06425073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38127
NINJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71284
KMS28BM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45658
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57626
BRD-K47814830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.56874
BRD-K30172718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04715
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_9219_KO_Mecp2_SRP056141	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	15.8331
CRCGN009_HEPG2_24H:D12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02356
MFSD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40861
ERBB2_knockdown_235_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.13741
Sarcoma_SARC_TCGA-WK-A8XT-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4462	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.38847
GTEX-XMD1-0011-R10A-SM-4AT4A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03638
NCIN87	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.70961
exemestane-165	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K98201103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29109
IGR-37	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929154
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.835533
PGAM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27758
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.70735
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2878
cerebellar cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.32662
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.19007
TMEM200C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25735
WM2664	CCLE Cell Line Gene Expression Profiles	-1.0	-1.60164
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CL-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K81619018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39054
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836559
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.072314
NOL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06877
PCDHB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2615
magnocellular (medial) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.992339
BRD-K91620436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06875
C1RL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5375
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.8109
EPLC272H	CCLE Cell Line Gene CNV Profiles	1.0	1.48719
EYA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57349
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.26874
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44647
NR2F1	Pathway Commons Protein-Protein Interactions	1.0	null
MHHNB11	DepMap CRISPR Gene Dependency	1.0	2.42561
sulfasalazine-204	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.41679
STOM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08361
ASH2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58569
SOX9-25088423-EMBRYONIC-GONADS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.18698
H3K27me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97707303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40083
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.84758
Lung squamous cell carcinoma_LUSC_TCGA-39-5031-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_3H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.94335
JHH4	DepMap CRISPR Gene Dependency	1.0	3.91948
PRECLH	CCLE Cell Line Gene Expression Profiles	1.0	1.7688
GSE138001_0_v_3_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
naltrexone-1363	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4746-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Hepatic cecum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.149
ZNF236	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29257
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.38923
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10X-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Embryonic brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.169
SD-69-QA40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.363313
CRCGN016_MCF10A.TP53.M_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.5671
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.29478
SW156	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K63354944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0889
Perturb_15600_KO_Twnk_SRP319510	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.12819
A431	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ovary	HPA Tissue Gene Expression Profiles	1.0	0.837191
GSE126345_4_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H209	GDSC Cell Line Gene Expression Profiles	1.0	2.55778
GTEX-QDT8-0011-R1A-SM-32PKS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41017
BRD-K16330310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18071
BRD-K93126086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59219
PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table5_Fig_S-Supplemental_Table_5_The_Effect_of_Drugs_on_LPS_induced_Tolerant_Cells_Supplementray_Fig_1D_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-V955-1926-SM-4KL1L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831835
CRCGN016_MCF10A.TP53.M_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33788
ZNF732	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40206
BRD-K44126416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55254
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IMR32	DepMap CRISPR Gene Dependency	1.0	6.0121
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D3REFED24h_1198_AR-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WL46-0011-R6A-SM-3LK6X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05807
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931084
BRD-A53381587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34156
GTEX-RVPV-0011-R3A-SM-2TF63	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50408
GSE126127_0_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4415_KO_Eed_SRP172483	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
NCI-H1793	GDSC Cell Line Gene Expression Profiles	1.0	1.4515
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972267
temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.308251
KATNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06161
NB10	DepMap CRISPR Gene Dependency	1.0	2.82527
AFG3L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76821
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
MAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79795
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01047
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.43281
ZNF622_02_108	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.50434
TEX30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39755
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.825296
BRD-K09168812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31268
COASY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96712
GSE158197_2_v_10_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.591
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51312
NOTO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27484
deferoxamine-485	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
anterodorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.84337
NR3C1-34362910-WISTARRAT-HIPPOCAMPUS	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K93613839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41499
GTEX-P78B-1326-SM-3P611	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27866
HCC1195	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80538
BRD-K42526449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69486
BCL2L11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04321
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.69815
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.5264
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A2QR-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JHU029	DepMap CRISPR Gene Dependency	1.0	2.77295
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CH157MN	CCLE Cell Line Gene Expression Profiles	1.0	1.3478
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
orbital frontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13225
Mathematical Ability	DisGeNET Gene-Phenotype Associations	1.0	null
SF539	BioGPS Cell Line Gene Expression Profiles	1.0	0.88419
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MH-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SYT13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30589
ZNF888	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85427
GTEX-QVUS-0011-R4A-SM-3GAE7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00776
NB17	DepMap CRISPR Gene Dependency	1.0	2.94963
Hypb_Deficiency_GDS3641_523_mouse_Yolk sac from E10.5 embryos	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SRSF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1475
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.912855
KKU100	DepMap CRISPR Gene Dependency	1.0	2.73595
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.18008
CRCGN009_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42214
Perturb_4964_KO_WWOX_SRP277498	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.39513
MEL-JUSO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
U2SURP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.97599
NCIH2141	CCLE Cell Line Gene Expression Profiles	1.0	1.9435
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.942376
EFM19	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.70176
ventrolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10822
GTEX-S7PM-0626-SM-4AD4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901234
BRD-K60543885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1699
BRD-K00048155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07279
GSE174701_1_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K25646425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28964
Metallo-dependent phosphatase-like	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K96280720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50641
BRD-K79676802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14031
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.15635
neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.045223
GSE193351_1_v_2_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE108675_2_v_1_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.18885
BRD-K56024445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10116
GSE164757,GSE164759_4_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K98749544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22661
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1243
T3M4	CCLE Cell Line Gene CNV Profiles	1.0	1.79284
BRD-K56889360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95102
HIKESHI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24025
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE81803,GSE81912_3_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41964
KLF4-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ARL8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3537
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
POM121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.20954
SMAD4-21741376-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
KRIT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17193
RPP38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47311
BRD-K97761115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03046
KCNG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.58748
KCNS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90481
EXOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99761
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059717
ZDHHC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59476
GSE205291,GSE205292_1_v_3_drd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DDRGK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21838
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KM12	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.26492
SKMEL28	CCLE Cell Line Gene CNV Profiles	1.0	1.74845
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_62_KD_Ccnt2_SRP312148	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.25285
BRD-K12909905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3655
CCDC85C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2567
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45156
MARCKSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24177
BRD-K95213130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11104
POTEF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60589
BRD-K52863921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62462
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.43349
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.27159
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-5398-01A-02R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33986
Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A40U-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62636
morphine_mus musculus_gpl6246_gse17731	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE94814_2_v_3_reck_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CYB5RL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45275
TMEM131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01689
KM12	BioGPS Cell Line Gene Expression Profiles	1.0	0.880989
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63238
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45Z-01A-21R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIAS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1814
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE199092_2_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SNRPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3201
chr22_43483368_G_A_b38	GTEx eQTL 2025	1.0	1.59764
BRD-A78042852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04325
GSE88819_0_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TIMM17A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0672
hsa-miR-1260b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.624
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7628
GSE220520_3_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ALLSIL	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71733
GSE220520_3_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_ALL-SYMBOL_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
Pterygium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.025
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65816
SNB19	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.28863
U87MG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70184
BRD-K16911140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20293
GSE142684_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K55855103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0001
COPG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08952
BRD-K46942548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29765
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	1.0	3.6531
STAG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.538
Idiosyncratic drug effect_Hepatic Tissue_GSE2825	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.59289
GSE112714_2_v_0_ctnnb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08329
H3K27me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82882121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45345
GSE71468,GSE76476_2_v_1_rbfox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HEXB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.3704
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10707
CHCHD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40937
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE126345_0_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HMEL	CCLE Cell Line Gene Expression Profiles	1.0	2.07568
C11orf68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.943
GTEX-RNOR-0011-R4A-SM-3GAD3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31707
SHROOM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80344
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.9129
dorsolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.52081
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2235
SubthalamicNucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.05288
BRD-K26682747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98685
Brain Lower Grade Glioma_LGG_TCGA-HT-8015-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA2	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A719-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
BRD-K97391170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02645
BRD-K32974773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11023
786-0	GDSC Cell Line Gene Expression Profiles	1.0	2.22248
GSE152441,GSE152442_1_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.5532
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D3_1784_AR-DEGS-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U8T8-1126-SM-4DXUE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824539
anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.841119
BRD-K09414286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13578
HCC1897	CCLE Cell Line Gene Expression Profiles	1.0	1.47101
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76215
ventral lateral nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.96308
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5468-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A5B5-01A-21R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K56381552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.47157
BRD-K45495792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10333
GSE158431_2_v_0_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BRD-K35440877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11105
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EJ-11A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATXN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1637
PTDSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9319
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6953
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.980317
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919199
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83853
KYSE-140	COSMIC Cell Line Gene Mutation Profiles	1.0	null
heart disease	GWASdb SNP-Disease Associations	1.0	0.714752
AC-50-FR41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206646
ARFRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13016
KELLY	CCLE Cell Line Gene CNV Profiles	1.0	1.38044
BRD-K68605096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02089
retina	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.02213
molecular_function	GO Molecular Function Annotations 2015	1.0	null
SNU719	DepMap CRISPR Gene Dependency	1.0	2.40627
BRD-K36095954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1973
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99446
Perturb_6199_KO_Elp3_SRP065804	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.65748
LUC7L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9012
BRD-K97595801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15098
SCAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35337
RS11846	BioGPS Cell Line Gene Expression Profiles	1.0	1.22828
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6907-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K06203116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83902
GTEX-QVUS-2826-SM-3GADB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28638
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
primary motor-sensory cortex (samples)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0927
Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85592
BRD-K20068050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01802
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21477
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.9357
NCI-H1793	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SCNN1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63805
enzalutamide_homo sapiens_gpl570_gse44905	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.173678
CTCF	ENCODE Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EJ-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71455
BRD-K87080069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27897
BET1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62185
TUB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55289
BRD-K76023734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05099
GSE211983_0_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mRNA_EOMES_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
COR-L279	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE118794_2_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K16673836	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28597
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58832
FSBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37644
SYK_KD_GDS3609_441_human_MCF10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
MYC-19915707-AK7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HCC2935	CCLE Cell Line Gene CNV Profiles	1.0	1.50069
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68929
GSE214514_1_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OCT1-27270436-CHIP-SEQ-PROSTATE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE123372,GSE123373_10_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JOSD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17368
BRD-K99119142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22867
DLL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.11717
ISTMEL1	DepMap CRISPR Gene Dependency	1.0	2.9076
BRD-K78908189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05215
ASPHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.66951
Brain Lower Grade Glioma_LGG_TCGA-HT-7688-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LEPROT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51776
NANOG-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NF-21-HQ00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206615
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4857
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17599
hsa-miR-513a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5080-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71V-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gata1_15895080_e12dot5_liver_megakaryocyte_lof_mouse_gpl1261_gds1316	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.73407
BRD-K56106571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1496
SERF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37184
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-143	TargetScan Predicted Conserved microRNA Targets	1.0	0.062888
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7353-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3689a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.1325
Meningococcal infection_Umbilical vein_GSE4646	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.25657
icSARA deltaORF6_7Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.05401
BRD-K79228133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90083
AC-11-BO01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235367
L428	DepMap CRISPR Gene Dependency	1.0	3.1846
CD37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77802
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.923388
SFRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34031
GTEX-QVUS-0011-R3A-SM-3GAFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42911
Sarcoma_SARC_TCGA-DX-A3UC-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE245270_2_v_0_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
DNAJC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97685
NHLH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42486
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3319-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPATS2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29273
PHAX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26234
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18659
monorden-449	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_8591_KO_Fto_SRP097869	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.2402
TBX20-22328084-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
REST-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
HCFC1R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25582
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.32286
ChIP_REST_18959480	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53971
TEAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4688
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95757
SIN3A	ENCODE Transcription Factor Targets	1.0	null
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908805
GSE126127_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76721
BRD-K56591923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33751
BRD-A02927672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35404
Excitatory neuron_Hippocampus_Human	CellMarker Gene-Cell Type Associations	1.0	null
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4302
BRD-K81181894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29067
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17007
CRCGN014_HEPG2_3H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45196
BRD-A23193246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31192
mRNA_MEF2C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
SMAD2/3-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
DIRAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30832
SNU410	CCLE Cell Line Gene CNV Profiles	1.0	1.78515
Brain Lower Grade Glioma_LGG_TCGA-DU-A6S6-01A-21R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47392
Prostate adenocarcinoma_PRAD_TCGA-J9-A52B-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38516
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.910486
hsa-miR-1273f	TargetScan Predicted Conserved microRNA Targets	1.0	0.045136
BRD-K42232544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02644
GTEX-OXRN-0011-R10A-SM-2I5GC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42889
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60292
NCIH1876	CCLE Cell Line Gene Expression Profiles	1.0	1.86368
BRD-K29898553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78975
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050731
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73144
mRNA_DLX3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Rectum adenocarcinoma_READ_TCGA-G5-6572-02A-12R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PSME4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44241
X	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.828997
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.082818
NCIH2073	CCLE Cell Line Gene CNV Profiles	1.0	1.70384
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-7082-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K28923989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01306
GSE224556,GSE224557_8_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.38842
BRD-K00804254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06889
GSE218580_1_v_4_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UTHO-2426-SM-4JBHD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06608
BRD-K26591929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17724
OVISE	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.24876
hsa-miR-1197	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GSE126345_2_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PCGF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42143
SMG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80993
BRD-K28139946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94947
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.2125
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K86946907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15226
NKAIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.51953
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28869
TIA1_KO_GSE54418_266_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
TK1	Pathway Commons Protein-Protein Interactions	1.0	null
CAOV4	DepMap CRISPR Gene Dependency	1.0	2.08119
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0702
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.29068
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	4.04034
Prostate adenocarcinoma_PRAD_TCGA-VN-A88Q-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PW2O-1426-SM-48TCD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904844
hsa-miR-335	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
SHSY5Y	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62636
RCHY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72165
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.1824
VMRCLCD	DepMap CRISPR Gene Dependency	1.0	2.56634
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.980567
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_HA-GENE_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K83752863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42031
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.49461
GSE158197_6_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.88841
FBXO6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39741
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5581-01A-02R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K32522318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59603
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4109
SSH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23954
KYSE-150	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0483
PXMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05473
BRD-K93391478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12381
Perturb_17276_KO_Uxt_SRP135119	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.44342
mRNA_KLF4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2807-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13164804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04394
NBPF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.45422
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.50939
H3K9me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.1807
Sleep (1/2-day periodicity)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.93408
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4817-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K00509345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8613
VMRC-RCZ	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MOCS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30584
BRD-K08205503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91029
hsa-miR-544b	TargetScan Predicted Conserved microRNA Targets	1.0	0.107229
primary motor cortex (area M1, area 4)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.870816
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76978
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MTPAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.71141
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.4745
GSE94814_1_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180813,GSE180815_1_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44205
ZNF470	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.44205
CRCGN017_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9234
TBL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.43888
BRD-K90746817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11921
TBK1_knockdown_53_GSE17643	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.01432
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59954
Lung squamous cell carcinoma_LUSC_TCGA-90-A4ED-01A-31R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.74255
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28366
BRD-K47092271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.22023
posteroventral (inferior) parietal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.845148
PYGL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48182
cancer	GWASdb SNP-Disease Associations	1.0	0.038615
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5546-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
liver	HPA Tissue Gene Expression Profiles	1.0	1.26486
GLRX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98101
RAD54L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9535
RET_mutant_23_GDS3319	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.58564
hsa-miR-4434	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
BRD-K95521279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25277
LARP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85863
PBX-27287812-CHIP-SEQ-EMBYONIC-LIMB-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.1739
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27404
LONRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3508
genistein-638	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K48691065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02323
FHOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05985
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.266764
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.929983
CD55	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31747
MEOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18608
Subiculum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.428
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H64	GDSC Cell Line Gene Expression Profiles	1.0	3.14437
Femur bone mineral density x serum urate levels interaction	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
mediodorsal nucleus of thalamus_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17414
SKMEL28	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45748
UMRC2	CCLE Cell Line Gene Expression Profiles	1.0	1.3542
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62539
TENM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30085
BRD-A89354030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31273
BRD-K55884477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08789
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0585
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-0.894173
GTEX-TSE9-0011-R10A-SM-3DB7O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42712
BRD-K78596805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61907
GSE143955_1_v_2_ripk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MS-2625-SM-3LK77	GTEx Tissue Sample Gene Expression Profiles	1.0	0.979521
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CUL4B	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.12075
EPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94088
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ERA-27197147-CHIP-SEQ-ENDOMETRIOID-ADENOCARCINOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
levetiracetam_rattus norvegicus_gpl1355_frontal cortex_gds1864	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LIVF001-009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5288
BRD-K06830450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50327
CRCGN016_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.61673
MMP17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45635
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A3-11A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61544
PHF8	ENCODE Transcription Factor Targets	1.0	null
BRD-K18304318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15357
Perturb_4146_KO_Bcl11a_SRP334609	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	17.3841
PMC2263127-pone.0001816.s001.xls-E2F3_up_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_3H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.21673
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052432
bleomycin-sulfate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08042
BRD-K12175788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37486
GSE233049_1_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
AICD_Induced  expression / Over-expression_GDS1979_288_human_SHEP-SF neuroblastoma	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHMP4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85829
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.139245
BRD-K23393992	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15151
SOX9-25088423-EMBRYONIC GONADS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GMS-10	GDSC Cell Line Gene Expression Profiles	-1.0	-1.92595
TMX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4983
AR	ChEA Transcription Factor Targets	1.0	null
GTEX-OHPK-2026-SM-3MJH7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00327
BRD-K39087168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24677
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-3.52104
KRTAP13-4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12478
DHX33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4612
TIA1_KO_GSE54418_265_mouse_midbrain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00832
BRD-K68732617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56645
CRCGN015_MCF10A_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.85816
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.86643
Body wall muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.829
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.5393
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.990109
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57035
REST-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HCT15	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.8634
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.11605
cerebralcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23083
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.20542
Prostate adenocarcinoma_PRAD_TCGA-V1-A8WS-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GPR150	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74496
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.839727
18614019-TableS4c	GeneSigDB Published Gene Signatures	1.0	null
PAM complex, Tim23 associated import motor	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.651
SMDT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73304
UCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10632
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
C2CD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42816
testis_7e	HPA Tissue Sample Gene Expression Profiles	1.0	0.933865
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.920913
BRD-K26472648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15629
hsa-miR-4435	TargetScan Predicted Conserved microRNA Targets	1.0	0.045136
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.871
GSE238005_5_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05626
BRD-K91962463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17816
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SEPTIN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.44267
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PURG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07122
A498	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.956565
BRD-K80736363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65438
Hormone producing pituitary cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.393
posteroventral (inferior) parietal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.904134
CRCGN015_MCF10A_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8533
GTEX-UTHO-0011-R3A-SM-3GIK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36046
EZH2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_MTF2_20144788	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
medial nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.8564
brain_3c	HPA Tissue Sample Gene Expression Profiles	1.0	1.59227
ZNHIT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29498
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.21295
BRD-K02929561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50205
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20-D3_1775_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HOXD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28912
BRD-K62318087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63053
indometacin-452	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trachea	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.920638
sulindac-168	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.290815
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78O-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE173873_10_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TMEM127	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75062
GTEX-PWO3-0011-R3A-SM-2I5EX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20235
Perturb_4425_KO_Eed_SRP172483	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	15.1247
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876551
Colon transversum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.547
NCIH1092	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59447
lateral group of nuclei, left, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.949322
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71605
KRAP_Deficiency_GDS3527_566_mouse_Brown adipose tissues	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.086942
SRC_activemutant_51_GSE15815	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	4.04159
oocyte	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.868511
PMC8554124-DataSheet4.XLSX-6-HOXB6_HOXB6	Rummagene Transcription Factor Associations 2026	1.0	null
SNU-C2B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SMAD3	MotifMap Predicted Transcription Factor Targets	1.0	null
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_9-Supplemental_Table_9_Limma_DE_Analysis_of_HC_AA_to_EA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WZTO-0011-R6B-SM-4E3J6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856938
BRD-A20213616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3804
DoTc2-4510	GDSC Cell Line Gene Expression Profiles	1.0	2.09411
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.78614
BRD-K34262858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09023
BRD-K04336022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23998
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K19040732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06395
TOV21G	CCLE Cell Line Gene Expression Profiles	-1.0	-2.05846
PAQR8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83862
PANC0504	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42449
CEP135	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8198
A2058	Achilles Cell Line Gene Essentiality Profiles	1.0	1.05966
hsa-miR-1272	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Lung squamous cell carcinoma_LUSC_TCGA-22-1012-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.237
MTCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39511
CRCGN012_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5701
MCRIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74349
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
thyroid gland	HPA Tissue Gene Expression Profiles	-1.0	-0.894173
Acute Myeloid Leukemia_LAML_TCGA-AB-2898-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K07029108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3455
BRD-K43017905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31222
RNF208	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76581
verapamil-161	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K13044705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11075
RecQ family helicase-topoisomerase III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.166
FAM221A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7878
ventrolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.853891
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.877674
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.7939
SW1990	GDSC Cell Line Gene Expression Profiles	1.0	1.43921
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Neuronal dense core vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.263
CCNJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.18998
LS411N	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.2226
CRCGN015_HEPG2_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.00105
CBFA2T3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58171
TTC38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41001
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81475473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83575
CREB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9092
isoflurane_rattus norvegicus_gpl341_control_gds2037	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4749-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
NCI-H446	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PM-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JHH7	CCLE Cell Line Gene CNV Profiles	1.0	1.48076
BRD-K86208187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02923
MRPS18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15352
primary auditory cortex (core)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01634
CRCGN015_HEPG2_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.53448
KLHDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42631
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7261-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K82539366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14979
GSE174701_4_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39971
BRD-K66541877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03711
DISC1	Pathway Commons Protein-Protein Interactions	1.0	null
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34245
PMC11880379-41467_2025_57480_MOESM3_ESM.xlsx-FOXP1_RIME_Limma-Gene_FOXP1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4343-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.43857
vascular disease	GWASdb SNP-Disease Associations	1.0	0.084685
PMC6347838-13046_2019_1042_MOESM3_ESM.xls-PRDM16_group_peak_anno-Gene_PRDM16	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62324
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241017
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67508
BRD-K49666076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.75165
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.01977
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.2008
all	GWASdb SNP-Phenotype Associations	1.0	0.036437
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34932
MYL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57727
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050636
SUP-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8295
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96445
ZMYM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33543
GLRX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56161
ZSCAN23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49299
TBX20-22080862-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K57404319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48473
CRCGN015_MCF10A_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16016
TCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71693
GSE173307,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	1.0	null
STK17A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71723
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07773
RCOR3-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K84990603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0301
SNU478	CCLE Cell Line Gene CNV Profiles	1.0	1.36941
LRRC8D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43495
GAK	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
Posterior amygdala	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.98
HCC1187	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.19586
PDP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49956
CELF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29496
GSE100464,GSE100465_0_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CUL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23198
ROS50	DepMap CRISPR Gene Dependency	1.0	3.90414
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TIMM17B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88712
U937	CCLE Cell Line Gene CNV Profiles	-1.0	-2.16409
BRD-K89216747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67618
MTF2-20144788-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-4436a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BRD-K75997540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23962
GTEX-XLM4-0011-R2B-SM-4AT5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85279
Temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.224
BRD-K65112040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56072
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.93005
H3K27me3_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7898758-40168_2020_994_MOESM4_ESM.xls-STAT1_target_genes-Gene_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
CD63	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49011
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.82203
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923407
BRD-K75360899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14424
NELFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.18391
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0155
19351829-SuppTableC	GeneSigDB Published Gene Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.52462
PI4KB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24686
CDK10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03474
BRD-K21416096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0079
DHTKD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20826
novobiocin-437	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
DNER	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91358
GTEX-TSE9-3026-SM-3DB76	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55947
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.13765
Perturb_17320_KO_miR106b~25_ERP121195	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-16.0296
Spinocerebellar ataxia type 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
PTCD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36076
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACOT13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32045
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
DYNC2I1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55305
GDE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78109
Chromosomal deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
CRCGN008_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8001
GSE246053_1_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
F5	CCLE Cell Line Gene Expression Profiles	1.0	1.38044
Uterine Carcinosarcoma_UCS_TCGA-N6-A4VE-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.077137
NCI-H747	COSMIC Cell Line Gene Mutation Profiles	1.0	null
19351829-SuppTableA	GeneSigDB Published Gene Signatures	1.0	null
ventrolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.38543
BRD-K85500722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00725
BRD-K08113936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50572
DDX47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02299
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
centromedian nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18601
BRD-K55160477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6396
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91084
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56712
BRD-K98720112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04006
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5062
Perturb_13819_KO_YBX1_SRP222969	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.5675
CD320	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.99887
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.8985
GSE86507,GSE86509_0_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
VPS25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90708
HCC1143	CCLE Cell Line Gene CNV Profiles	1.0	1.32983
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
SNU620	DepMap CRISPR Gene Dependency	1.0	6.18823
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-NFE2L2_NFE2L2	Rummagene Transcription Factor Associations 2026	1.0	null
SOX2	ChEA Transcription Factor Targets	1.0	null
LNZ308	CCLE Cell Line Gene Expression Profiles	1.0	1.4103
BRD-K80073743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44055
RRAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.10328
SRY-22984422-TESTIS-RAT	ChEA Transcription Factor Binding Site Profiles	1.0	null
EGR1-20690147-ERYTHROLEUKEMIA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K96054771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22205
CRCGN016_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.23602
novobiocin-342	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE174498,GSE174500_2_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC70	DepMap CRISPR Gene Dependency	1.0	5.01392
B4GALT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07992
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01798
NMRAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60587
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13805
RELA	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE245270_2_v_3_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
UBQLN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55177
GTEX-UTHO-0011-R4A-SM-3GIJP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9773
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M5-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EPHX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27479
SUPT11	CCLE Cell Line Gene CNV Profiles	1.0	1.97083
hsa-miR-548c-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
outer CP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22842
ANKRD46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52542
BRD-A07214340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47489
F5	DepMap CRISPR Gene Dependency	1.0	2.27573
CALHM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10763
Lung adenocarcinoma_LUAD_TCGA-93-A4JN-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TGOLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.59612
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GLYATL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22953
GSE152441,GSE152442_1_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35877
GSE172020_1_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.15972
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2IR-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142684_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X261-0011-R10B-SM-4E3JT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20062
ETF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55686
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
RAPA_EARLY_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9723
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.84
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.66075
H2AL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75188
Prostate adenocarcinoma_PRAD_TCGA-H9-A6BY-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64522
GTEX-UTHO-3026-SM-3GAFB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39942
NR3C2-34362910-WISTARRAT-HIPPOCAMPUS-STRESS	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-T6MN-0011-R4A-SM-32QPG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894313
TLX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43821
GSE210842_3_v_1_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.4136
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
SMC3	ENCODE Transcription Factor Targets	1.0	null
HT144	DepMap CRISPR Gene Dependency	1.0	9.08245
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.3313
BRD-K72707702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04529
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.35863
GTEX-XBEC-1526-SM-4AT68	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12853
LIVF001-025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05567
Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE186287_1_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K17821077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00422
EMX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.12962
mRNA_SFPI1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
chaperonin-containing T-complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.885
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K57226763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00564
GSE142684_3_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ADGRB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8653
ZNF30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42077
LN215	Achilles Cell Line Gene Essentiality Profiles	1.0	1.27373
Pheochromocytoma and Paraganglioma_PCPG_TCGA-PR-A5PH-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6284
JHOM1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.10977
GSE210101,GSE210114_1_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
INSYN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50388
THBS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21487
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1091
STARD3NL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03202
BRD-K33865795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66285
BRD-K67533212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75193
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.03018
NTF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69082
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_HA-SYMBOL_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K76892938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4722
Gender incongruence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.543
PMPCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49946
Lung adenocarcinoma_LUAD_TCGA-44-7670-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K37971917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80054
NCIH2081	CCLE Cell Line Gene Expression Profiles	-1.0	-1.75806
BRD-K42435091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.343
colon	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.906131
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CFAP97	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39036
LAMTOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90578
GTEX-UPIC-0926-SM-4IHLV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80624
MM127	DepMap CRISPR Gene Dependency	1.0	3.05194
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73C-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9304
BRD-K96243955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19213
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.04208
Sarcoma_SARC_TCGA-SI-A71Q-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.946069
BRD-K92759025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08132
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17152
BRD-K86893953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22605
Lung squamous cell carcinoma_LUSC_TCGA-85-8580-01A-31R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
limbic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23459
496100584_HIP_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.58821
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.86007
hsa-miR-4725-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51973
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.87274
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7064337-elife-51373-supp1.xlsx-EZH2_targets_shPHF19-List_of_2084_genes_marked_by_EZH2_ChIPseq_after_PHF19_KD_shPHF19_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7610-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.77478
abnormality of cardiac morphology	GWASdb SNP-Phenotype Associations	1.0	0.615351
ZNF177	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11801
GTEX-OHPN-0011-R3A-SM-2I5FC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921058
POMP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43479
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9477
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04245
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.74292
GTEX-N7MT-0011-R3a-SM-2I3GC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12577
ZNF613	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60701
BRD-K77139764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21801
BRD-K89992188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20007
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A2-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE102870_3_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02255
GTEX-PWO3-0926-SM-2I5EY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0529
KIAA1586	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73405
SNU1214	CCLE Cell Line Gene Expression Profiles	1.0	1.50005
GSE210580_3_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC2814	CCLE Cell Line Gene Expression Profiles	1.0	2.67985
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.17839
BRD-K73497584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21302
ChIP_K27me3_17603471_mouseMEF	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BAG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31974
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXA2_FOXA2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199092_3_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126127_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K20016759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27729
Charcot-Marie-Tooth disease type 4B3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
Perturb_4414_KO_Eed_SRP172483	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-16.5665
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.192
BRD-K63614330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69877
SNU81	DepMap CRISPR Gene Dependency	1.0	3.85504
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsal subdivision of VLC	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08483
BRD-K13798725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03744
HIV - Human immunodeficiency virus infection_Peripheral blood mononuclear cell_GSE2171	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.55248
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258707
ACOT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06413
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5881-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.96417
COLO849	CCLE Cell Line Gene CNV Profiles	1.0	1.64975
BRD-K70052888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73905
PPP1R1A_KO_GDS1920_708_mouse_hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_7G-MAX_KO_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WVLH-0011-R4A-SM-3MJFS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2997
Dynein axonemal particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.063
GSE206270_1_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A4FUK	CCLE Cell Line Gene CNV Profiles	-1.0	-1.78032
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90072
AARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50495
BRD-K58025976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30507
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.0435
BRD-K46001734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96946
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54763
Chromatin silencing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.587
BRD-K76600600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05587
ZNF559	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02336
BRD-K98890753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06073
CRCGN017_MCF10A.WT.HP_24H:A21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04225
Mesothelioma_MESO_TCGA-SC-A6LM-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KRTCAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3673
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-X6-A8C7-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
D502MG	DepMap CRISPR Gene Dependency	1.0	2.24251
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3122
ANXA7	Pathway Commons Protein-Protein Interactions	1.0	null
CD56+_NKCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.924437
endoplasmic reticulum	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K50700697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18712
Cervix - Endocervix	GTEx Tissue Gene Expression Profiles 2023	1.0	3.43565
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.16158
SUP-HD1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6928094-395_2019_765_MOESM7_ESM.xls-DEGs_AR7_vs_Pre-patterned-List_of_differentially_expressed_genes_in_AR7_vs_Pre-patterned_cells_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.28918
JHOM1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.81434
CCDC134	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91011
GSE196671_6_v_8_obox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null