association	dataset	threshold value	standardized value
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.57224
Charcot-Marie-Tooth disease axonal type 2T	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
GSE148066,GSE157787_9_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SW-626 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context3-Nearest_Ensembl_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K26709432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12774
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung non-small cell carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.191
BRD-K29936219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83609
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.11479
BRD-K97869597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09622
PC-80-LV29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29252
Jun	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.4252
BRD-K84949119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56883
BRD-K35726223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31713
BRD-K54484733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07015
Hereditary spastic paraplegia 9A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.307
TF-04-RX73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.394804
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1245
BRD-K51272331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45449
BRD-K84118789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11514
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE167324_1_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cardiovascular system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.001
FLII	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83715
BRD-K12801140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10374
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.374198
BRD-K81370109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2088
GSE93309_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11030494-media-2.xlsx-ST18-Unnamed_1_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_8_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-20-VR86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.516807
BRD-K45621617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.004
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4615001__F2	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K95365728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06958
rRNA methylation	GO Biological Process Annotations 2025	1.0	null
K562_Tanespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138151
BRD-K32127177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15585
BRD-K58644442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69091
BRD-K19710723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2912
GSE114992,GSE114993_7_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.934091
BRD-K58963469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19768
glycine-tRNA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.661
BRD-K94049419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68825
BE-27-RQ61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.37376
HC-18-NB46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320531
BRD-K45522895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.65737
BRD-K25226763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17904
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
VERO-76 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.502
RNA cap binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.366
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-GSEA_TET1-CCRF-CEM_SCR_vs_TET1_TET1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135352_0_v_1_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K82216975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09239
BRD-K03730976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2209
BRD-K68364310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14972
CRCGN017_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.48706
HDHD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78171
6071_PARK7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.519307
GSE168401_2_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20138377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05553
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Prdm14	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.0167
rRNA (uridine-2'-O-)-methyltransferase activity	GO Molecular Function Annotations 2025	1.0	null
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.939
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.166
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9472
KCTD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0995
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.672
RNA modification	GO Biological Process Annotations 2025	1.0	null
NRBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549391
EBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.2798
BRD-K18101782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80594
rRNA (uridine) methyltransferase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K87386611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91242
GSE65617_0_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.3343
GSE153867_6_v_4_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AE-04-SN76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.420127
BE-66-UB12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246265
BRD-K60287661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07188
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
PMC8764619-mmc7.xlsx-supplementary_table_for_the_Ven-GSE131737_TFAP2B_target_genes_G_gallus_1347_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K14082333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26259
GSE190384,GSE190386_2_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4615001__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8622
A549_UNC0379_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00851333
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.427849
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Zosuquidar	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
BRD-K30989303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24369
PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
496100500_PCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.90227
GSE190681_1_v_0_rtcb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GPN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07985
BRD-K73227372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00727
chr7_2236750_A_G_b38	GTEx eQTL 2025	1.0	1.95477
Sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.215
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Ensembl_ID_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K18594025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87766
BRD-K47535493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10852
MCF7_Glesatinib(MGCD265)_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136877
GSE122101,GSE122103_3_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_8_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K74978191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60998
BRD-K64536135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41213
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
143B	DepMap CRISPR Gene Dependency	1.0	2.10322
BRD-K78088874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03919
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.95124
BRD-K24418561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80941
Mood disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.023
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.543
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	44.9371
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09695
BIN67	DepMap CRISPR Gene Dependency	1.0	2.25534
Tou	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.798
BRD-K60729758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24846
GSE206870,GSE206872_3_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.805
BRD-K56868780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54629
BRD-K24076516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58877
CRCGN015_MCF10A.TP53.M_24H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11185
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K36198653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65823
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.17173
BRD-K54872884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45013
GSE114992,GSE114993_8_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.518
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75495990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80948
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316255
BRD-K75626008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00706
PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Downregulated_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K24422491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64257
3-Methylcrotonyl-CoA carboxylase 1 deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.59
Gastroesophageal reflux disease	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.5699
CRCGN015_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.35805
ME-54-JY76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297048
MELAS syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.591
OD-13-IE31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269976
Inner ear disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.652216
BRD-K16891407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41572
kb NB 142-70	DeepCoverMOA Drug Mechanisms of Action	1.0	1.49
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.650361
BRD-A56427952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18837
GTEx Lung 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-9.03585
BRD-K97805186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15878
SLIRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27753
496100466_PCx_probable Alzheimer's disease_no TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.18268
GSE226249_0_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_1_TRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
BC-09-XQ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278883
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01559
IRX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29814
GSE135030_11_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K96431636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21745
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07003
496100526_TCx_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08729
BRD-K65107903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19145
BRD-K16976282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.83299
K562_CYC116_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161266
HUH6	DepMap CRISPR Gene Dependency	1.0	2.17997
Testicular cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.548
BRD-K28347985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69991
SNU398	DepMap CRISPR Gene Dependency	1.0	2.27456
nucleolus	GO Cellular Component Annotations 2025	1.0	null
CLDN11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02528
ribosomal large subunit assembly	GO Biological Process Annotations 2025	1.0	null
496100628_FWM_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.908
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K90644597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20858
BRD-K37262603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30429
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02465
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
A549_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143046
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mRNA cap binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.466
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7183
F5	DepMap CRISPR Gene Dependency	1.0	2.1724
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.491078
BRD-K91120514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40659
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K16626032	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14097
D458	DepMap CRISPR Gene Dependency	1.0	2.01399
BRD-K87554792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24409
BRD-K09308989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1527
preweaning lethality, incomplete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K75007044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03359
ribosomal large subunit assembly	GO Biological Process Annotations 2023	1.0	null
OE-84-HO42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.644608
BRD-K12106433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78938
ATAC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.741
BRD-K66253165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25079
GSE118766_2_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA_high-signal_selected_bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
mitochondrial matrix	GO Cellular Component Annotations 2025	1.0	null
CA-42-YI34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.393202
CAL51	DepMap CRISPR Gene Dependency	1.0	2.10354
CRCGN017_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.48662
BRD-K90675978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21926
GSE210101,GSE210114_2_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171837_0_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.705
BRD-K87343552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30556
MINK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4456
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.510531
BRD-K55779851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11259
Intracellular organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.077
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.14435
XBP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.132
CRCGN011_HEPG2_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05883
BRD-K79965790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10954
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07193
BRD-K28803288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05005
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.439438
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8769
RA-49-ZB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219664
MOLM14	DepMap CRISPR Gene Dependency	1.0	2.23797
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nuclear lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.787616
PMC11214527-mmc5.xlsx-TP53-gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LNCAPCLONEFGC	DepMap CRISPR Gene Dependency	1.0	2.09442
BRD-K62000282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68818
CRCGN015_MCF10A_48H:H13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44055
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.74033
PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.236
PMC4909395-elife-13964-supp1.xlsx-Sheet1-Supplementary_file_1_shRNA_screen_hits_selective_to_ERG-positive_prostate_cancer_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5273
eRF1 methyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.321
BB-23-PM31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214729
SW1573_LUNG	CCLE Cell Line Proteomics	1.0	2.50996
BRD-K14139166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94332
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K76611906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61355
BRD-K79497053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12318
BRD-K79658624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96586
BRD-K05335635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28161
BRD-K11165361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50426
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7--Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73573090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49527
AA-46-GL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259114
IPO7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63572
SON	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00648
DA-17-YW85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337796
BRD-A85028244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0325
BRD-K24752397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41406
TC-95-IR96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210651
BRD-K63145472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10831
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.9511
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.48249
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6889
ZFTRAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58038
BRD-K04706894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73289
BRD-K77834935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6315
GSE193258,GSE193259_2_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K53706972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69386
rRNA 2'-O-methylation	GO Biological Process Annotations 2025	1.0	null
CRCGN012_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09002
BRD-K01759041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92972
GSE143212_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE159678_6_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MC-40-IP75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.524071
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.848935
BRD-K99048639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06949
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.089
STK416816	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9356
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K45909830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93801
EC-82-LV30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.777053
AE-88-WQ63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.415862
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1972
chr7_2226749_A_G_b38	GTEx eQTL 2025	1.0	3.44135
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	135.01
Schizophrenia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.22218
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K42199095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46483
CE-37-XI06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.347913
BRD-K95666495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25888
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.39835
DC-23-UM36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237695
GSE147366_1_v_4_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE114992,GSE114993_4_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190950_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	-1.0	null
QE-00-EB96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.411017
BRD-K55105453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57927
PMC10795826-jciinsight-8-170518-s128.xlsx-Fig_5B-Gene_Regulated_by_VDR_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
AA-46-GL76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.412802
PMC11225427-13058_2024_1861_MOESM2_ESM.xlsx-Supplemental_Table_S4-Supp_Table_S4_AR_mediated_PGx-eQTL_genes_and_associated_with_all_GWAS_traits_from_GWAS_catalog_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K82433264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97562
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.13261
Connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.805
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GE-40-GQ38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31307
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348592
MFAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04348
Foxn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.4804
NCIH1155	DepMap CRISPR Gene Dependency	1.0	2.09182
NTAQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65748
ST6GALNAC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37046
BF-22-EP86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.459803
BRD-K83487481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53759
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.338741
SYCP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02264
GSE229973_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K07551625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29955
canthaxanthin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31055
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3342
Intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.077
Superior temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.859
Organellar small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.758
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.19377
BRD-K22988729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40488
BRD-K03381861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7262
CRCGN012_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13935
GSE240896,GSE240899_3_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SA-53-XG95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.745771
GSE192771_2_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135514_2_v_9_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00618
BD-04-NG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203647
BRD-K75583553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25921
FEV	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7769
BRD-K15928912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05661
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102757_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126463_4_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GOLM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35562
7505_RPS16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.708738
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UPCISCC131	DepMap CRISPR Gene Dependency	1.0	2.22775
BRD-K10398797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20549
BRD-K33102216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53368
BRD-K85622666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7678
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.27358
Auditory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
RNA processing	GO Biological Process Annotations 2025	1.0	null
NCIH1573_LUNG	CCLE Cell Line Proteomics	1.0	2.30126
BRD-K88099511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98767
BRD-K86545229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05492
TTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20493
Optic nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.125
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE162739_2_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SA-32-CC58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.06205
Perhexiline	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.85
BRD-K10416099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04111
BRD-K90806964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23397
ZNF461	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05937
VA-06-DB75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291528
GSE246660_1_v_0_lmo3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cytosolic ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.529
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.541466
GSE167224,GSE168147_1_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K98953112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45124
mitochondrial large ribosomal subunit assembly	GO Biological Process Annotations 2023	1.0	null
HSQ89	DepMap CRISPR Gene Dependency	1.0	2.06784
CRCGN011_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.13585
GSE193282_2_v_0_cd44_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K12011077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02839
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.023
Cytoplasmic exosome (RNase complex)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.575
LYRM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82425
Thiothixene	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.46
GSE95302_1_v_4_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	89.9215
TD-29-IN36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213263
GSE143944_1_v_3_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10280803-1415-4757-GMB-46-2-e20220358-s2.pdf-117-PRMT3_PRMT3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SW756	DepMap CRISPR Gene Dependency	1.0	2.23856
BRD-K21546432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04517
BRD-K29542628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02461
SNAI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0388
GSE148066,GSE157787_8_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-10-HD17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31229
8903_TIAL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.587202
BRD-K91952416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14981
BRD-K05250921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46701
MDAMB231_BREAST	CCLE Cell Line Proteomics	1.0	3.75556
UF-14-LK87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.603986
BB-86-UL91_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208038
BRD-K11782435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07321
BRD-K33438042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09943
Preribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.85
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FF-90-JK74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.639766
SYO1	DepMap CRISPR Gene Dependency	1.0	2.14651
Movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
BRD-K18865369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61952
BRD-K21356734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18811
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260866
PMC4212256-mmc5.xlsx-FLI1_log2_results-MIR622_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GB-73-QS80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.383436
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.9375
BRD-K47636083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21482
PMC12697907-ADVS-12-e07451-s002.xlsx-ST4F_MR-pan-cancer-out-Unnamed_2_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131680_1_v_0_macroh2a1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
9212_TPRKB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.538753
MF-81-RJ18_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262915
496100407_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.19632
PMC11814113-41467_2024_55326_MOESM3_ESM.xlsx-BP_Dorsalgia_GTExQTL_loci_MR-Unnamed_12_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22698363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39026
Male reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.548
MCF7_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014514
BRD-K20157822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17713
BRD-A37056613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04273
BRD-K50498614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3381
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Tucidinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121971
CRCGN016_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.58076
BRD-K03542527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91945
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K62170825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34034
GSE165678_0_v_5_stat5a_human	RummaGEO Gene Perturbation Signatures	1.0	null
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.3631
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.347694
PMC9013323-13577_2022_685_MOESM7_ESM.docx-25-IRF4_IRF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE254649_3_v_0_cstf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Bacterial degradosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.625
rRNA modification	GO Biological Process Annotations 2023	1.0	null
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE240386,GSE242143_1_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DNASE1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05546
GSE232558_0_v_2_fbxl12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9825
CRCGN015_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1868
BRD-K46924722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30018
BRD-K62358193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24961
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3227
GD-46-OD81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253658
BA-39-OX47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302655
BRD-K74056311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27116
GSE215351,GSE215794_4_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5668
tilorone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24514
MCF7_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128976
ZFYVE27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46919
Gastroesophageal reflux disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.705
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323217
GSE135350_2_v_5_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100555_TCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.07939
BRD-K73795883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83569
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.47729
ps90	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.114
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.24
HD-18-YL30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.402961
GSE208634_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-07-LL18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.560007
BRD-K76664579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53144
non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.077
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46432
BRD-K74933734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34276
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.882268
GSE195663_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.464
BRD-K75311902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11741
Autosomal genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.805
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bipolar I disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.404
BC-72-DZ30_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342151
BRD-K15426523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34664
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.74942
Immunodeficiency 11B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.565
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K73183447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39156
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-61-OO16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.81669
RNA methylation	GO Biological Process Annotations 2025	1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.767637
A549_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159529
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K20735575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27295
BRD-K81035073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43064
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JF-62-LU77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.524388
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
Melancholic depression	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.023
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.15356
GSE165122_0_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	71.1345
BRD-K16496880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58526
BRD-K13803936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02983
AB-84-PK04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224072
BC-72-DZ30_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265135
GSE229973_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
S0-EE-XMXE_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299202
BRD-K59239787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37467
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.902405
Male reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.548
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:L15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21168
CRCGN017_MCF10A.TP53.M_24H:J04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20366
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10864182-41588_2023_1596_MOESM4_ESM.xlsx-ST12_Significant_Genes_combine-Supplementary_Table_12_Genes_prioritisation_combining_FUMA_MAGMA_Hi-C_MAGMA_and_TWAS_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH2172	DepMap CRISPR Gene Dependency	1.0	2.21555
BRD-K17852428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53359
BRD-K35639494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.902
BRD-K38118226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23261
BRD-K07689069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48317
GSE149760_0_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K95740363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29735
BRD-K48670593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07163
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.762858
BRD-K61831307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97078
JF-45-JM50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233802
Mitochondrial DNA depletion syndrome 17	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.939
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.1914
AC-36-SY22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.355975
mitochondrial matrix	GO Cellular Component Annotations 2023	1.0	null
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3027
BRD-K41355409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22001
BA-68-FJ41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32655
Endocrine system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.548
GSE206729_4_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
Transient infantile liver failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.844
GSE143944_2_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TARBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13359
BRD-K94903598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.61412
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	77.383
Atf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.0615
BRD-K47200630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47587
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2836
PMC11979751-table_s2_markers_elad055.xlsx-Melanoma_GSEA_state_markers-AP2_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
EIPA	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.04
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.96
BRD-K77252933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40962
OF-05-CB18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.63069
GSE200839,GSE233826_2_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.979
BRD-K84636055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16152
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE114992,GSE114993_0_v_11_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.06478
abnormal retina blood vessel morphology	IMPC Knockout Mouse Phenotypes	1.0	null
GSE135030_3_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BT12	DepMap CRISPR Gene Dependency	1.0	2.0954
DAPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36148
GSE237426_0_v_1_eif4a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sensorineural hearing loss	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
BB-79-AG41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.551969
Testicular germ cell cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.548
WSUNHL	DepMap CRISPR Gene Dependency	1.0	2.22933
BRD-K02060635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61056
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3898
Monogenic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.805
intracellular non-membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
BRD-K37506332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25064
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29175
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.45155
Mitochondrial proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.747
Y-33075	DeepCoverMOA Drug Mechanisms of Action	1.0	0.64
BRD-K12145385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45884
GSE114690_1_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Infantile hypertrophic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.674
ESR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0228
rRNA modification	GO Biological Process Annotations 2025	1.0	null
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	115.017
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.70004
EIF5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21474
NCIH716_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.14964
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
6625_PPIE_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.593935
BRD-K53402320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42139
JR	DepMap CRISPR Gene Dependency	1.0	2.11386
ACER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27214
CRCGN016_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.23161
BRD-K89701103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25567
d2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.201
A549_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011561
Prdm5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.5486
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.43012
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.555602
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.37035
rRNA processing	Reactome Pathways 2024	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14188
496100516_FWM_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.60953
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256697
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.539589
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.676305
GSE102467_1_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Attention deficit hyperactivity disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.911
Organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.077
NB7	DepMap CRISPR Gene Dependency	1.0	2.30968
BRD-K97569931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18777
Congenital heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
BB-87-SF89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.445277
BRD-K28030757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14994
GSE111247_14_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K59087082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50481
BRD-K37850190	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32233
BRD-K42849858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37374
GSE236502_1_v_3_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ameloblastic layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
BRD-K20809650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.263
BRD-K33400588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07596
BRD-K42697646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42992
GSE237984_1_v_0_magi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
KCL22	DepMap CRISPR Gene Dependency	1.0	2.1643
GTEx BloodVessel 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-17.942
Spliceosomal tri-snRNP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.593
PMC5732738-oncotarget-08-103415-s002.xlsx-MFC-7_DEGs-Genes_with_significantly_different_expression_between_parental_MCF-7_and_GATA3_WT_clones_with_adjusted_P_value_0_05_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular organelle lumen	GO Cellular Component Annotations 2025	1.0	null
f94	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.385
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.419005
thiamphenicol-glycinate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0606
BRD-K13534347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18004
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251063
SKP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44428
GSE216352,GSE216354_1_v_0_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4171
BRD-K63730594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15633
Charcot-Marie-Tooth disease type 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.482
BRD-K29760532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59013
BRD-K28455914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66612
Hypertrophic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Outer dense fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.819
GSE81796_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K25573760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33158
AA-46-GL76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323689
BRD-K35799753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2425
GSE205316,GSE205317_0_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.748819
BRD-A26222320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40755
Large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.456
BRD-K12955049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44345
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.7008
TBX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9102
GSE195663_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE248858_1_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K73110675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23339
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.3067
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7801
CRCGN015_HEPG2_48H:B12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.69313
Blonanserin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.5
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229973_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K42679620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47367
Ophthalmoplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
GSE126762_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K52054012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13296
TARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29763
K562_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184414
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.0501
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K76154866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4226
SA-31-VB03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230906
BRD-K51104732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47325
GSE191110_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K88190816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01903
iron-sulfur cluster assembly complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.539
Mitochondrial chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.947
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.452532
BRD-K81001899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09536
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.1811
CRCGN015_HEPG2_48H:B20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53524
PLAZOMICIN	DGIdb Drug Targets 2026	1.0	26.466
UPCISCC040	DepMap CRISPR Gene Dependency	1.0	2.02844
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282788
BRD-K66538269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.45575
GSE201110_0_v_1_sirt4_human	RummaGEO Gene Perturbation Signatures	1.0	null
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.31825
HA-22-CY42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217977
Mitochondrial crista junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.743
BRD-K59049030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88748
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.2817
GSE169152_5_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K20024170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39708
B-lymphoblastoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.013
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE249544,GSE249637_9_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K42987166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51008
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.0829
BRD-K79318338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14388
GSE112761,GSE112767_4_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3425
BRD-K20160406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83736
BRD-K05734090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40784
BRD-K17854062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43256
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H4C15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10814
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317037
GA-47-MH68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289737
Chronic progressive external ophthalmoplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
Mitochondrial matrix	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3624
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.805
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K81006490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25628
EE-98-PF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.488101
GSE121866_0_v_2_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.077
NEK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06266
PMC11615365-41467_2024_54246_MOESM6_ESM.xlsx-KK47-Numb-KD_vs_Ctr-KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8139
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
FAM234A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1072
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Encephalopathy due to defective mitochondrial and peroxisomal fission 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.518
BF-94-CQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.379227
GSE226249_0_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
c32	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.539
BRD-K62309791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21613
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0486
MCF7_Tubastatin A HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142219
GA-77-MH38_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229324
Bipolar disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
BRD-K73394628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06196
BRD-K09227140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.54008
BRD-K03304013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12549
BRD-K43261169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46266
MD-86-UW46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336803
AS 1517499	DeepCoverMOA Drug Mechanisms of Action	1.0	0.91
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5256
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6683
BRD-K61168922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13201
EIF2B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17282
MDAMB468	DepMap CRISPR Gene Dependency	1.0	2.1606
BRD-K38724926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04642
BRD-K96567801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29892
GSE211983_0_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.087
BRD-K24206299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49523
RNF141	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27533
Lung cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.275
PMC10290283-biol-2022-0622-sm3.pdf-91-HEY2_HEY2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K34739404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37068
GSE202434,GSE202438_6_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Charcot-Marie-Tooth disease dominant intermediate E	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A172_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	6.79867
BRD-K28880788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33286
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GB1	DepMap CRISPR Gene Dependency	1.0	2.03803
GSE244730_0_v_1_erlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.19621
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337708
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228017_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148269,GSE148273_0_v_1_arid4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE208634_1_v_2_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE137144_2_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_9_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE207611,GSE207612_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A39407481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06244
GSE130437_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9387164-Table_2.XLSX-Sheet1-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92457070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96483
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HAP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.81
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.62892
Combined oxidative phosphorylation deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.142
Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
CRCGN015_MCF10A.TP53.M_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08175
PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K32930844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56659
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.31053
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5689
BRD-K78931693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0057
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.03294
LRRC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09783
GSE174383_2_v_7_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.0265
BRD-K24984327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09587
GSE201309_1_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context3-Gene_Name_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A30962679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17328
BRD-K96778009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27802
BRD-K48994888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01564
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.707409
PMC7553775-elife-61287-supp1.xlsx-Muller_2014_DREAM_bound_genes-Genes_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.054
Prostate disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.518
BRD-K62229896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07512
GSE125403_7_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tRNA-intron endonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.713
BRD-K83708664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10405
BRD-K23430426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2046
embryonic lethality prior to organogenesis	MGI Mouse Phenotype Associations 2023	1.0	null
GSE134375_0_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CEACAM19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00425519
CRCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17997
BRD-K79561909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49848
Nucleolus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE119978,GSE180930_6_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100408_PCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.68396
BRD-K14536501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.131
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K31110422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73423
BRD-K13486159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.45014
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A25883214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47247
BRD-K96778609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1144
BRD-K47143916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97071
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.552872
BRD-K07013504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24481
BRD-A69110668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40995
GSE135514_2_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.805
BC-43-JW95_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.536205
Macronucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.546
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160246_9_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
post-traumatic stress disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.489
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149123,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.95133
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K37254228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06201
GD-59-OG21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22275
BE-79-QU25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351113
CB-24-FA25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262887
rRNA (uridine) methyltransferase activity	GO Molecular Function Annotations 2025	1.0	null
GSE205163,GSE205164_3_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
chr7_2232345_C_T_b38	GTEx eQTL 2025	1.0	1.09994
BRD-K11781871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0762
BRD-K39979171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22778
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	1.0	null
Mitochondrial ribonuclease P complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.649
BRD-K28916436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10812
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.84025
CRCGN016_MCF10A.TP53.M_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25103
BRD-K77922263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.77554
GSE207514,GSE207515_0_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
BRD-K06116445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08737
LPCAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6228
rRNA modification in the mitochondrion	Reactome Pathways 2024	1.0	null
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kinetoplastid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.413
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5418
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213323
Transcription export complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.302
GSE199606_3_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K51760683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87533
BRD-K11577431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65632
BRD-K26543702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.59609
CE-37-XI06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266823
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	1.0	null
HELT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35811
BRD-K83815065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21121
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.02296
GA-04-JM33_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200549
GSE148066,GSE157787_2_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.923031
membrane-enclosed lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.077
RNA 2'-O-methyltransferase activity	GO Molecular Function Annotations 2025	1.0	null
GSE150055_0_v_1_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
Tachyzoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
DC-23-UM36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203086
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.527737
BRD-K00363054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08548
cytochrome-c oxidase deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.47
MCF7_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126689
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.692581
PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_TAZ-CAMTA1_vs_EV-Gene_CAMTA1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K32477623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19614
GSE213588_9_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
INTS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09246
CRCGN015_MCF10A_48H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56539
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.32614
D423MG	DepMap CRISPR Gene Dependency	1.0	2.25369
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.518
Nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5937
CHP134	DepMap CRISPR Gene Dependency	1.0	2.10316
BRD-K09117810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22655
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A16760970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07289
GA-16-IU17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212218
Rhabdomyosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.046
PMC10322841-41598_2023_38117_MOESM7_ESM.pdf-9-FOXF1_FOXF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K76008396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16976
BRD-K13196166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45488
EB-67-WB79_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270715
BRD-K18488784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41471
GSE213219_0_v_1_st3gal3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:E21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00804
BRD-K20215591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79739
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49395
HSPBAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23845
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.954388
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13265
CHLA266	DepMap CRISPR Gene Dependency	1.0	2.12368
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_down_VENN-1175_elements_included_exclusively_in_HIF1_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5773
BRD-K91593159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03157
GTEx SmallIntestine 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-3.03652
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.513
SMARCD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18802
KELLY	DepMap CRISPR Gene Dependency	1.0	2.26849
Small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.403
BRD-K72437469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11996
macromolecule methylation	GO Biological Process Annotations 2025	1.0	null
BRD-K36171309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20734
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.512728
GSE173201_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Organellar ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.614
ZNF320	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	159.036
PMC11030494-media-2.xlsx-ST18-Supplementary_Table_18_Significant_results_from_TWAS_of_internalizing_spectrum_using_PsychENCODE_samples_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K11269634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4017
PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTF3C5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27075
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K45421483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53934
BRD-K30121969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70371
BRD-K25280080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17731
BRD-K35863275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35207
GSE167956_4_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
PACADD161	DepMap CRISPR Gene Dependency	1.0	2.12146
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234396
GSE132408_1_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.758
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.6918
USF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18163
PMC12824661-BLOOD_BLD-2024-027020-mmc6.xls-Table_S14-HES4_Up_HES4	Rummagene Transcription Factor Associations 2026	1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.920887
BRD-K24396733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13543
C8orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34838
BA-95-YU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.605259
HUPT4_PANCREAS	CCLE Cell Line Proteomics	1.0	2.46682
embryonic lethality prior to organogenesis	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K01995700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13759
GSE236486_1_v_0_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_6_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K05699155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09217
BTN2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30702
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164529_0_v_2_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210476_11_v_4_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.40928
BRD-K20091931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35143
BRD-K08941280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52458
BRD-K20245846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02765
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.8428
6043_PAK1IP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.579144
BRD-K09972656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02217
nucleolus	GO Cellular Component Annotations 2023	1.0	null
BRD-K63859730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1833
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.75658
BRD-K84457681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42631
BRD-K31987278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43972
GSE171712_0_v_1_scgb1a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_2_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K64767126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01134
Autism spectrum disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.815
BRD-A43409498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04096
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.334
Lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.013
Metabolism of RNA	Reactome Pathways 2024	1.0	null
IA-27-CK10_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326486
GSE110440_2_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K32362211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42098
HT	DepMap CRISPR Gene Dependency	1.0	2.31526
BRD-K95941120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7294
Mitochondrial degradosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.14
GSE143512,GSE143513_0_v_1_nr4a3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
non-syndromic X-linked intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.265
BRD-K84423439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59793
BRD-K44897610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55963
MF-41-QM60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219936
NCIH1568_LUNG	CCLE Cell Line Proteomics	1.0	9.10952
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-D-Enh_Aza_atRA_DE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
ATPAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56646
AA-24-UO04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203608
BRD-K18385869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37238
BRD-K26074237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03608
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.02329
Neonatal period electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.313
ID-00-IC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282636
BRD-K46162352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15137
PC-68-DU31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236172
BRD-K34370545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12961
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10863267-12864_2024_10083_MOESM1_ESM.pdf-227-PRDM12_PRDM12	Rummagene Transcription Factor Associations 2026	1.0	null
GSE206226_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K43029808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25162
GSE148066,GSE157787_3_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300169
Optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
Charcot-Marie-Tooth disease type 1D	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
BRD-K08043579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11748
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95077_5_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF630	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67049
BRD-K41322154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16188
BRD-K57830670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24376
Combined oxidative phosphorylation deficiency 23	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.454
BRD-K17078647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05209
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K02839126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.54478
PF-04620110	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K37803976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16549
PLEC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32128
GSE200897_1_v_0_pold1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RPS10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26303
PCI38	DepMap CRISPR Gene Dependency	1.0	2.15421
BRD-K06876397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52968
HOXD13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60562
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.915566
succinate-CoA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.692
FD-62-ZB67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209561
EB-67-WB79_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.61946
mc2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.826
CROCC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.289
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.7014
CRCGN015_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.76094
RBM39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46505
PMC7339546-12915_2020_793_MOESM2_ESM.xlsx-Table_S12-Table_S12_common_twin_genes_in_one_HMR_core_region_between_cattle_and_human_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.35208
PMC11912729-12967_2025_6368_MOESM1_ESM.xlsx-S5-S5_Identification_of_Genes_Causally_Linked_to_IPF_through_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K94196749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97131
Combined oxidative phosphorylation deficiency 35	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.697
PPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33428
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.501137
GSE213228_2_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46114
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_DN_AA_DN-AA_DN_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K32078195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95143
MCF7_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158357
CRCGN017_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.04642
OCILY3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.34358
GSE121866_0_v_3_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K87080232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06532
CRCGN013_HEPG2_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05431
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.379725
mRNA cap methyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.517
SB-29-ZH97_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.602448
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.53971
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	103.937
496100358_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16249
BRD-K11504463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13427
BRD-K13038935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27013
GSE216273,GSE216292_14_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.36253
Organellar large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.973
BRD-K47694606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0611
Perrault syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.529
BRD-K28700379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59279
GSE241701_2_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
f95	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.17
decreased total retina thickness	MGI Mouse Phenotype Associations 2023	1.0	null
CRCGN014_HEPG2_24H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10499
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
BRD-K70851916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44518
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.472295
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28956
CCNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1243
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.55647
MCF7_Celecoxib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146112
CRCGN015_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9766
BRD-K68298468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14489
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
ND-54-NO97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260682
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.86187
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160246_0_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240896,GSE240899_10_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.870478
GD-59-OG21_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267122
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6483
LAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90139
BRD-K87290989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42306
Root apex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.053
CRCGN015_MCF10A_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.45685
Intracellular non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.077
BRD-K14193598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03784
GSE155031_5_v_1_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K22694513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27711
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4793
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07936
BRD-K71414336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23558
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K77101974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14563
BC-26-LE04_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.678856
PMC9314667-Table_1.xlsx-Regulons-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
ETV5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9308
BRD-K43240808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28954
BRD-K52139780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84282
GSE175787_11_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.805
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TFDP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5964
BRD-K16681480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28238
SRSF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52149
AB-71-CI37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215543
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
Thyroid	GTEx Tissue Gene Expression Profiles 2023	1.0	6.29765
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207779
BRD-K65752097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53175
GSE235390_4_v_0_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_0_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.669608
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.52175
AC-49-NG46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211935
PMC11615365-41467_2024_54246_MOESM6_ESM.xlsx-KK47-Numb-KD_vs_Ctr-KD-ensemblGeneId_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K80630598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33014
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206516,GSE206518_5_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-77-QQ71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217782
BRD-K73579545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08998
GSE158834_2_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-87-EI21_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.555795
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195514_0_v_1_stk25_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12571657-DataSheet1.pdf-16-ELF1_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.23475
GSE239844_6_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tRNA (m2G10) methyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.327
BRD-K89652482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03439
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.39227
HEC50B	DepMap CRISPR Gene Dependency	1.0	2.31995
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4084
BRD-K10087503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06598
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.58427
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.96269
MCF7_PJ34_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133665
BRD-K60052521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11513
GSE122509,GSE122513_3_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268379
CRCGN008_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06603
PMC4954754-elife-15550-fig3-figsupp1-data1.xlsx-HSF1_Genes-Unnamed_18_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_11_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.27497
MCF7_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136651
GSE111247_11_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186287_2_v_0_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K52335877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26638
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128333_4_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K41202439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22472
GSE169155_5_v_7_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6299
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.4086
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chr7_2229157_G_A_b38	GTEx eQTL 2025	1.0	1.03671
GSE134375_4_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K69349031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84793
preweaning lethality, incomplete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.72119
PMC10280803-1415-4757-GMB-46-2-e20220358-s2.pdf-117-ENSG00000185238_PRMT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K89770910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01633
BRD-K98723391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28161
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Anxiety disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.489
PTAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11443
ncRNA processing	GO Biological Process Annotations 2023	1.0	null
BC-75-FA82_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.39878
BRD-K16525290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22284
BRD-K37219127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.488
GSE201668_0_v_1_ncor2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Huh-7.5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.377
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.39582
DB-41-IH69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219013
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.51742
BRD-K18139667	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02796
Mitochondrial metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.753
BRD-K42799692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79021
GSE111035,GSE111040_8_v_5_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.16597
CRCGN017_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19249
Ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.395
PMC10913870-pr3c00632_si_001.pdf-84-ZC3H8_ZC3H8	Rummagene Transcription Factor Associations 2026	1.0	null
DA-85-SU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.820602
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7178
PMC12335956-BNEO_NEO-2024-000529-mmc1.xlsx-4_chr7essentials_published-THP1_Wang_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
A3KAW	DepMap CRISPR Gene Dependency	1.0	2.14414
143B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.923
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.805
BRD-K88934376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40783
CRCGN017_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43516
TC-95-IR96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314874
CRCGN015_HEPG2_48H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24515
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.9652
GSE165122_0_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K38218737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35474
Alpers-Huttenlocher syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.268
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K02529187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31752
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24169
GSE123638,GSE123639_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FNDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20035
BRD-K19814171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41563
C19orf47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1907
JAR	DepMap CRISPR Gene Dependency	1.0	2.21427
GSE148066,GSE157787_2_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.24639
GSE213588_9_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mucocyst	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.916
BRD-K73088636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42131
JHH5	DepMap CRISPR Gene Dependency	1.0	2.09524
BRD-K23292451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43279
rRNA metabolic process	GO Biological Process Annotations 2025	1.0	null
BRD-K53387776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41491
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5133
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K67430561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16667
BRD-K62370517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33237
BRD-K60635455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46358
TSEN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11539
GSE173873_1_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K18409585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00695
PMC10534007-Table_2.xlsx-S2_overlap_MSC_down_B_V-395_common_elements_in_VM-CUB1_MSC_down_and_BFTC905_MSC_down_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
CREB3L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7913
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56605
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
BRD-K35288418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13591
JVM3	DepMap CRISPR Gene Dependency	1.0	2.01871
CRCGN016_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.87548
MV411	DepMap CRISPR Gene Dependency	1.0	2.23
496100491_HIP_no dementia_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02908
BRD-K21384875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1661
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE218879_1_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K27331198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68024
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.5338
abnormal retina blood vessel morphology	MGI Mouse Phenotype Associations 2023	1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.26867
BRD-K87803080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22178
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.20189
GDPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15111
NCIH23	DepMap CRISPR Gene Dependency	1.0	2.21109
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222539
IE-80-DC24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28114
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K45537529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19203
NCIH2004RT	DepMap CRISPR Gene Dependency	1.0	2.23578
Sideroblastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.273
TE11	DepMap CRISPR Gene Dependency	1.0	2.21698
BRD-K78866450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27434
GRIK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49626
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.1139
GSE112761,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K67980271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45658
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5114
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.497466
BRD-K27911943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15405
BRD-K43918582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09647
Bipolar disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.404
NFYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2368
BRD-K52231251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30741
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K54112192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04003
BA-68-FJ41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256436
Respiratory system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.275
BRD-K18562194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89199
BRD-K44003352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13271
CRCGN016_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.78316
CWF19L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06342
BRD-K64698045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55181
FKBP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15682
GSE128333_2_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226115,GSE226116_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NS-0 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.834
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.812495
BRD-K43387144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99784
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.02325
MRPL20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25522
COVID 19 structural coverage map	WikiPathways Pathways 2024	1.0	null
FZR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27546
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4421
U251MGDM	DepMap CRISPR Gene Dependency	1.0	2.06646
GSE169155_5_v_2_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140074_1_v_0_kif20a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K51535480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07023
GSE152050,GSE152052_1_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K34677894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98853
CRCGN015_MCF10A_48H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32177
GSE239844_6_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169152_3_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.537
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7713
GSE152734,GSE152735_1_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
B-lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.013
CD-47-YL43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.523104
BRD-K15714771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70577
GSE151494_1_v_4_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Npas2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.9267
BRD-K28927944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04665
mitochondrial ribosome assembly	GO Biological Process Annotations 2023	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16337
MCM10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33652
BRD-K14070721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88657
CRCGN017_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30512
BRD-K98637033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3437
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
BRD-K12067186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83436
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.988608
EIF2B5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00693
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20600965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53228
CRCGN015_MCF10A_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00734
BRD-K95023134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20264
GSE160304,GSE163392_0_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149760_3_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BAY 61-3606	DeepCoverMOA Drug Mechanisms of Action	1.0	0.82
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K46715415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01678
BRD-K46239950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55393
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	156.053
GSE235701,GSE261434_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.191
5762_NPAT_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21965
SF3A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44397
Spastic ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SPOUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15716
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3811
BRD-K20918933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89923
PC-87-OG75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267695
BRD-K74486924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78359
CTU2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61868
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K06619604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09202
Lung carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.275
BRD-K51175229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25032
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.69794
KP4	DepMap CRISPR Gene Dependency	1.0	2.09687
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.14184
BRD-K94275706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27571
BRD-K81669067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20933
nuclear lumen	GO Cellular Component Annotations 2025	1.0	null
JHH7_LIVER	CCLE Cell Line Proteomics	1.0	3.23967
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K47903820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03242
Mitochondrial ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.623
CRCGN016_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1257
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9947
CRCGN017_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17183
XD-44-FJ34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290766
TASOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07897
RELCH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24961
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CE-69-HJ13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29143
Exoribonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.203
AA-46-GL76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.575002
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.48063
GSE236437_2_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K59667434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88104
SLC16A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41018
BRD-K75206417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88409
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7726
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225752
BRD-K86268010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75742
COV434	DepMap CRISPR Gene Dependency	1.0	2.28229
sc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.876
CRCGN011_HEPG2_24H:B23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2161
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
BRD-K98757606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17845
Ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.096
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.0424
BRD-K53335788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40891
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.48142
PMC3371315-NIHMS350140-supplement-10.xls-MCF7-T47D-SK-453_Down_SK-453_xl-Supplementary_Table_3_ER-negative_FOXA1_signature_Genes_decreased_only_in_MB-453_and_SKBR3_cells_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4573
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.452366
BRD-K57045425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08443
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.83499
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K42457027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01355
BRD-K89402302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16044
BRD-K63111122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26259
BRD-K18334106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.382
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTDSPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11872
GSE239688_4_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.23112
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.88598
BRD-K44298652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35689
AE-52-NW93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.517318
BRD-K15739647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44117
CHST6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2817
RNA 2'-O-methyltransferase activity	GO Molecular Function Annotations 2023	1.0	null
KYSE-150 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.517
F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07937
BRD-K63864604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04007
FA-80-DR66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334148
PMC10944835-41467_2024_46639_MOESM4_ESM.xlsx-SD17-Supplementary_Data_17_Differentially_expressed_genes_according_to_homozygous_genotype_at_the_TWIST1_locus_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164959
BRD-K77032979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34563
4593_LIN52_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.606545
Intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0272
BRD-K11054031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23768
Cranial nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05481
BRD-K75674991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06056
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.68007
BRD-K19536737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07917
Mitochondrial DNA depletion syndrome 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.113
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238083
TC-95-IR96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230526
BRD-K94580242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36732
BRD-K17482709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63118
GSE111247_11_v_9_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.494845
GSE126776_0_v_1_pelp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
docebenone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34417
ARMCX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12643
rRNA processing	GO Biological Process Annotations 2025	1.0	null
GSE207135_1_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH1703	DepMap CRISPR Gene Dependency	1.0	2.24808
BRD-K48235533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36975
Prostate cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.518
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.74652
GSE261563_9_v_4_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PF-59-CY33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.02346
PHKG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34685
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K16643911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21973
TMEM219	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64757
DOK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69982
BRD-K62372121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1976
BRD-K57205873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25963
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.5306
SK-MEL-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.069
Eplerenone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.4
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0612
COLO792	DepMap CRISPR Gene Dependency	1.0	2.26238
BRD-K50474387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36172
intracellular membraneless organelle	GO Cellular Component Annotations 2025	1.0	null
GSE188458_2_v_0_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Ramelteon_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157101
NB69	DepMap CRISPR Gene Dependency	1.0	2.12417
RPMI2650	DepMap CRISPR Gene Dependency	1.0	2.22623
SAMD4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59913
BRD-K21296995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56672
PMC2263127-pone.0001816.s001.xls-E2F3_up_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
PC14_LUNG	CCLE Cell Line Proteomics	1.0	3.13886
TE-671 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.534
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.635782
496100431_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.56172
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.815
Paracentral lobule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.615
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46878
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229914_1_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K33510044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0869
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.508413
BRD-K09376136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50883
GLI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.9421
GSE167224,GSE168147_3_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-11-HV98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25636
GSE137144_4_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Early myoclonic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45589
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
rRNA (uridine-2'-O-)-methyltransferase activity	GO Molecular Function Annotations 2023	1.0	null
XC-81-LR46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.836353
non-syndromic intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
KMM1	DepMap CRISPR Gene Dependency	1.0	2.24787
MON	DepMap CRISPR Gene Dependency	1.0	2.08925
BRD-K35879814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59927
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.361114
10737_ZWILCH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.560581
BRD-K03265347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10182
BRD-K27540772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13067
BRD-K29519734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11431
GSE193993_4_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.6635
SORBS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06512
BRD-K39087188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0814
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K92891227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03674
Mitochondrial DNA depletion syndrome 4b	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229973_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K98086832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08329
BRD-K08576275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75042
chr7_2233301_A_G_b38	GTEx eQTL 2025	1.0	1.62931
BRD-K04147413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62762
ZNF135	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.6108
AA-48-XT80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.498295
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9438
BRD-K89324382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83266
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.204
MCUR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55198
TE-26-XS06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.62566
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22815
GSE236437_0_v_3_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.705
BRD-K22475995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35512
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K60454848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72732
BRD-K27885385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00469
OF-47-EQ74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235113
BRD-K32582260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02451
Pervasive developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.815
GSE227698_2_v_1_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CME1	DepMap CRISPR Gene Dependency	1.0	2.0156
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4535
FBXO31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07569
KU812	DepMap CRISPR Gene Dependency	1.0	2.15777
BRD-A81407814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67774
GSE128844_0_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
mitochondrial ribosome assembly	GO Biological Process Annotations 2025	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Oral apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.619
Metabolic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.659
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K73014869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10673
Dense fibrillar component	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.571
Testicular disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.548
MCF7_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00922137
BRD-K41563239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34074
BRD-K47271260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26603
RPS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87545
GSE133213_11_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cognitive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.023
BRD-K60192542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55677
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
GSE237040_2_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-38-UW72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294984
Mitochondrial DNA depletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.781
3213_MRM2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.584085
proton-transporting two-sector ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.901
TRAF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24048
JD-58-MV19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32632
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.0809
Specific developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.911
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.65691
CE-95-YX02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207203
PMC12571657-DataSheet1.pdf-16-ENSG00000120690_ELF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE168097_3_v_2_epinephrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE192870_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mitochondrial large ribosomal subunit assembly	GO Biological Process Annotations 2025	1.0	null
Lactic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.874
BRD-K33986892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17937
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	1.0	null
DB-41-IH69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265779
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.544385
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.3453
CHLA10	DepMap CRISPR Gene Dependency	1.0	2.12586
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.884
BRD-K16940345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.802
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237986
BRD-K87131514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05371
BRD-K16468319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45119
AF-80-GK24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244743
Trichocyst	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.771
GSE241701_4_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
XA-82-BM12_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260133
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.382533
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A26343863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17092
BRD-K04834648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08083
BRD-K46913557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24661
CRCGN016_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55401
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
8897_THTPA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.544023
GSE111247_11_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180147_0_v_1_itga5_human	RummaGEO Gene Perturbation Signatures	1.0	null
KRBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37863
Nucleolus	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.077
ACADVL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13444
RPS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12909
BRD-K00048792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22753
BRD-K29120026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4309
JB-89-SI60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23831
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.523909
BRD-A73635700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36234
Sleep disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.551
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.24796
BRD-K57784254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61981
GSE169152_3_v_1_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FU97	DepMap CRISPR Gene Dependency	1.0	2.17069
BRD-K13087600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26725
BC-15-EL49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.443869
CRCGN017_MCF10A.TP53.M_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13835
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-5.9248
BRD-K26431593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59974
Leigh disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.474
BRD-K50721666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67338
BRD-K01512588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20529
MTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15645
HEC59	DepMap CRISPR Gene Dependency	1.0	2.10972
ARMCX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12397
tRNA methyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.844
BRD-K20068050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11212
PC-80-LV29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23953
CRCGN016_MCF10A.WT.HP_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26532
GSE240386,GSE242143_1_v_4_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K57365604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60569
BRD-K27599706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60069
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
Mitochondrial matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.097
Heart disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.001
GSE111247_14_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7585942-mmc4.xlsx-RBM10_KD-Unnamed_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K27864398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.57826
Ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.044
ZNF417	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5536
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.4797
decreased total retina thickness	IMPC Knockout Mouse Phenotypes	1.0	null
GSE124410_2_v_4_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K13488816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07115
BRD-K10459972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11749
BRD-K02334683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17494
GSE229973_4_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GD-82-CS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203127
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_PSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K62781263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08868
BRD-K21423945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16426
GSE111247_11_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Major depressive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.023
UF-14-LK87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.539933
GSE203158_5_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.687145
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K12929741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56277
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148066,GSE157787_3_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lower respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.805
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K08241590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77083
PMC3874167-supp_gkt849_Supplement_Table_S1.xls-DREAM_-_unclear_TSS_affiliation-Gene_name_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
BRD-K28008176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38425
BRD-K31870622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18123
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Symbol_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
PROKR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13218
BRD-K83994491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19194
BB-77-QQ71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.43343
BRD-K93611325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17954
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204247
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.795206
BRD-K20184768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33429
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DB-41-IH69_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279027
GSE65617_2_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BB-11-JI42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.377326
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.368311
PIGT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25234
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.9924
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.811434
chr7_2237993_C_G_b38	GTEx eQTL 2025	1.0	1.81657
PRCC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09054
GSE172458_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE80537_3_v_2_adhfe1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K17965071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04224
A375SKINCJ2	DepMap CRISPR Gene Dependency	1.0	2.00505
TOV112D	DepMap CRISPR Gene Dependency	1.0	2.00815
RAB41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58492
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.63479
GSE111247_11_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BE-17-CS60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.561377
BRD-K11581306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55077
tRNA-specific adenosine-34 deaminase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.371
BRD-K06743908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77718
MFSD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49128
ZBTB7C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.2
CRCGN015_HEPG2_48H:G20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70202
GSE240896,GSE240899_2_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
OVK18	DepMap CRISPR Gene Dependency	1.0	2.26505
BRD-K47461610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20539
BRD-K91937280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49047
RBM47	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00488156
BRD-K00551139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13958
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.1333
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305891
Gonadal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.548
Exosome (RNase complex)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.567
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.278
PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30566330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39277
BRD-K73874262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80181
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.604964
Uterine corpus cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
BRD-K46291400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29896
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Uterine corpus endometrial carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.18
TFE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22661
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.81611
GSE186647,GSE217288_1_v_4_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.48902
RNA modification	GO Biological Process Annotations 2023	1.0	null
GSE130676_0_v_2_suds3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213048_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
tilmicosin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61582
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.8116
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TOV21G	DepMap CRISPR Gene Dependency	1.0	2.09528
C16orf87	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44148
AC-30-XU83_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330188
TLDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08278
Mitochondrial myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.828
AA-62-JP26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237978
U937	DepMap CRISPR Gene Dependency	1.0	2.24449
BRD-K07035171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28022
PMC4954754-elife-15550-fig3-figsupp1-data1.xlsx-HSF1_Genes-Unnamed_12_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_9_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ERMES complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.726
WDR11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40139
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.5833
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.384664
BRD-K79402882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34755
ribosome biogenesis	GO Biological Process Annotations 2023	1.0	null
GSE193351_1_v_2_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18115
Squamous cell carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.191
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K65774385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03574
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K83547183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14206
BRD-K20437312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21915
Flp-In-T-REx cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.561
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23649
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.494455
GSE174383_2_v_5_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143944_1_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
F36P	DepMap CRISPR Gene Dependency	1.0	2.22391
GSE255988_2_v_0_ethanol_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.39529
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153354_0_v_1_tcf19_human	RummaGEO Gene Perturbation Signatures	1.0	null
Rhabdomyosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.118
GSE221577_3_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K84974041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3379
GSE217132_0_v_1_pfkfb4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K85716998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40996
BRD-K46293468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06177
GSE157904_3_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FANCD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0342
CIP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30019
PMC6113333-41598_2018_31192_MOESM11_ESM.xlsx-Sheet1-H1_NFIC_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
SNB19_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	2.73988
ribosome biogenesis	GO Biological Process Annotations 2025	1.0	null
BRD-K77718491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18251
KC-32-GO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336865
XPO6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14226
BRD-K94088431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26628
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.58017
Cpa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.563
BRD-K16331797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90831
Glufosinate	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
BRD-K23960050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35338
BRD-K16109630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59501
nuclear lumen	GO Cellular Component Annotations 2023	1.0	null
BRD-K20530300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53184
CRCGN015_MCF10A_48H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23342
VA-06-DB75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.515714
Interstitial lung disease 2	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.805
HC-11-RK51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.571067
FZD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04454
GSE200673,GSE200691_2_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.771
GSE140441_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K73494324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31387
301_ANAPC10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.721118
Combined oxidative phosphorylation deficiency 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.838
BRD-K11089039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3155
rRNA processing in the mitochondrion	Reactome Pathways 2024	1.0	null
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim22_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
rRNA 2'-O-methylation	GO Biological Process Annotations 2023	1.0	null
BRD-K77082178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21059
GSE217776,GSE217829_1_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4067464-onc2013378x3.xls-Sheet1-Supplementary_Table_1_Top_1000_E2F4_Chip-Seq_targets_that_are_repressed_by_p53_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
DC-43-KF54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.34208
CE-23-HP88_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222829
GSE154464_1_v_2_cdk6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K44932450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3531
BRD-K08433493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.54348
AE-04-SN76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324062
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K85216683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05617
BRD-A59995060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39402
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K79072801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41727
CRCGN015_HEPG2_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13359
tRNA (m7G46) methyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.677
PMC10952034-mmc3.xlsx-Table_S2-Table_S2_Pooled_shRNA_screen_analysis_to_identify_genes_selectively_required_for_the_proliferation_of_the_cells_with_the_highest_MYC_signature_score_Related_to_Figure_1_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE196259_2_v_0_gcm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0604
2747_ESYT1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.657324
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.7523
BRD-K58194737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18646
BRD-K26063034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42883
BRD-K50045741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25997
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5467
GSE143782_3_v_4_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20028052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24635
TDRD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23577
GSE239844_6_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-74-RX30_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345377
GSE149621_2_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
8666_TAF5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.562877
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.1131
chr7_2217536_G_C_b38	GTEx eQTL 2025	1.0	1.11968
KYSE180	DepMap CRISPR Gene Dependency	1.0	2.22302
KA-71-CQ35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.660734
BRD-K16689648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8439
BRD-K56041932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9785
RL	DepMap CRISPR Gene Dependency	1.0	2.07962
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180789_1_v_0_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
TIMM8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99785
EOL1	DepMap CRISPR Gene Dependency	1.0	2.17053
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim29_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
JF-84-QZ64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.388615
WM2664	DepMap CRISPR Gene Dependency	1.0	2.03415
GSE112860_5_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12697907-ADVS-12-e07451-s002.xlsx-ST4F_MR-pan-cancer-out-Unnamed_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71852
GSE137144_2_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BE-66-UB12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285256
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
BRD-K48046422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02184
BRD-K57650037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13912
Temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.933
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VERO C1008 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.601
BRD-K69453266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49463
RBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32529
BRD-K50596260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3674
BRD-K72175798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14047
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
BRD-K40923781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12363
Hereditary spastic paraplegia 55	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.492
BRD-K05802716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46597
BRD-K90694955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25118
Mitochondrial nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.947
BRD-K61505971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57898
GSE205729,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.73549
BB-86-BE19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.479479
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2515
BRD-U28903152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07724
BRD-K81642886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24539
FUOV1_OVARY	CCLE Cell Line Proteomics	1.0	7.43686
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.556265
RAB40A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59294
BRD-K95508535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24512
496100305_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.28793
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_1_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE134029_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K59130962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45127
CCLP1	DepMap CRISPR Gene Dependency	1.0	2.28514
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.544558
rRNA metabolic process	GO Biological Process Annotations 2023	1.0	null
BRD-K12226398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32052
RNA methylation	GO Biological Process Annotations 2023	1.0	null
5447_NADSYN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.55231
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.548
GE-63-WI86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331955
ZHX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38033
MAP4K2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09036
BRD-K92607052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22918
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.6684
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.307
CRCGN015_MCF10A_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.67838
Reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.548
BRD-K57795803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13295
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.21373
HIP1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0877
TD-48-XJ84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.665129
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199255,GSE199356_4_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular organelle lumen	GO Cellular Component Annotations 2023	1.0	null
Autosomal dominant disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.805
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.726175
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.9685
ZNF692	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0256
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.83936
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6412103-mmc1.docx-5-M00695_ETF_P_8_350E-5_N_428_31_5_1_TEAD2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200214_0_v_2_mrgpra1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.61798
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3751
BRD-K29661539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07444
GSE235066_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K65564503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23941
SCCOHT1	DepMap CRISPR Gene Dependency	1.0	2.18752
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.023
CSTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04823
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_DN_NR2F1_ind_DN-NR2F1_Ind_DN_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207766
BRD-K73357447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.111
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.548
GSE145171_0_v_1_prox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K59542165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0109
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6
Autism spectrum disorder or schizophrenia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.51549
GSE121866_1_v_3_six4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BE-38-UW72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.723285
HBMEC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.55
GSE199255,GSE199356_4_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K31896531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21684
496100426_PCx_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16112
BRD-K72161690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19543
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.548
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.676502
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-D-Enh_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
T47D	DepMap CRISPR Gene Dependency	1.0	2.02788
PMC10244410-41467_2023_39054_MOESM5_ESM.xlsx-PIE-LIN28B-GeneSymbol_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE163297_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Zfp961	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.2793
PDE12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04907
Depressive disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	2.023
BRD-K89362730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34628
MCF7_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131601
BRD-K79576342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51889
GSE171180,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Ramelteon_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146019
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.539971
ZNHIT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20787
CREB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.339
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.27816
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25964
BRD-K22957824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55167
BRD-K20183527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46708
496100402_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00472
BRD-K17059629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53019
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.411
GSE239844_8_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.529066
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.790615
BRD-K24170552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58961
BRD-K70116387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50546
BRD-K18519876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68336
BRD-K56950366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95623
GB-73-QS80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.81945
BRD-K83569804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26678
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE200839,GSE233826_3_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K91459693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64093
BRD-K82506716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07401
Ribonuclease P complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.874
GSE202434,GSE202438_8_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE76771_1_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
rRNA methylation	GO Biological Process Annotations 2023	1.0	null
GSE175787_11_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148096_1_v_0_erlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OCIAML2	DepMap CRISPR Gene Dependency	1.0	2.22036
BRD-K81810589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85649
CRCGN016_MCF10A.WT.HP_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.97129
BRD-K12473406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21777
b19	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.338
PNLDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26141
BRD-K07781799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80174
PMC2263127-pone.0001816.s002.xls-Terms_with_Genes_E2F3_up_Bild-Title_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148657_2_v_1_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JA-88-IO52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.65199
496100652_PCx_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13898
BRD-K89175823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24308
BRD-K11596967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48828
BRD-K76738405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43197
BRD-K27754030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1344
BRD-K17893805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18521
BRD-K30761927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0929
PMC13127299-mmc2.xlsx-PBX1_kdRNAseq-hgnc_symbol_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
Dimensional psychopathology (Social)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.669897
Interstitial lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.805
MF63	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
Mitochondrial encephalomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.951
ARHGAP23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11445
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.761513
FD-15-HD09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.672005
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.98485
BRD-K50716325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56026
HGC27	DepMap CRISPR Gene Dependency	1.0	2.02455
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE233679_5_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.61428
BRD-K24070365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13874
rRNA processing	GO Biological Process Annotations 2023	1.0	null
GSE111247_14_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K17821077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29183
BRD-K42575648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77352
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232558
FLO1	DepMap CRISPR Gene Dependency	1.0	2.01575
GSE137177_1_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K32485819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25065
CRCGN015_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.76879
BRD-K09454191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01836
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K35324337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41522
BRD-K62807053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09972
UA-39-TN76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219289
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
Polysomal ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.607
BRD-K18573205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09449
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20185935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1693
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
BRD-K65891102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96969
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K32066855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05647
proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.906
BRD-K31059159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05563
Nuclear lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	2.077
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K93051667	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2084