association	dataset	threshold value	standardized value
K562_Baricitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197286
GSE226285_2_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K76628294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87575
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.465382
epithelial-stromal TGFBI dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.474725
EA-02-ZO63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.334905
Synaptonemal complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.794
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.391784
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.702265
NZOV9	DepMap CRISPR Gene Dependency	1.0	3.07958
BRD-K11804865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02964
GSE158834_1_v_3_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.8619
BRD-K16919185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08804
GSS	DepMap CRISPR Gene Dependency	1.0	15.0311
almotriptan	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45917
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4492
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.931
GSE158834_2_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9516
GSE167956_1_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOXB5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5392
GSE60217_1_v_0_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nucleus	GO Cellular Component Annotations 2025	1.0	null
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K75413392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08222
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.729436
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41252
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72347
SLC16A7+ cell_Lung_Human	CellMarker Gene-Cell Type Associations	1.0	null
496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.48429
PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal male meiosis	MGI Mouse Phenotype Associations 2023	1.0	null
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.36401
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7583
BA-68-FJ41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260087
7142_RBBP6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.35488
BRD-K39547688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6087
GSE126463_5_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166914_1_v_0_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ADRB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40096
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K87080069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06646
AA-48-XT80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227617
GCM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.336
AA-23-FM46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.416895
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308424
Kidney - Medulla	GTEx Tissue Gene Expression Profiles 2023	1.0	3.55304
GTEx Heart 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	3.65988
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327959
GSE60217_1_v_2_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE94011_0_v_3_pias3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Dexmedetomidine_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0186021
DEL	DepMap CRISPR Gene Dependency	1.0	3.10405
GSE128076_1_v_3_doxycycline_human	RummaGEO Drug Perturbation Signatures	1.0	null
MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.35775
TAGLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74889
pre-replicative complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.006
HCT15_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	3.28024
CRCGN015_HEPG2_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.82299
GSE202825_2_v_1_ano1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
thiamphenicol-glycinate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39107
GSE249544,GSE249637_9_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12824661-BLOOD_BLD-2024-027020-mmc6.xls-Table_S14-HES4_Up_HES4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221327_8_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326435
BRD-A78085235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16697
GSE213228_1_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nobox	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.0263
CCLFPEDS0003T	DepMap CRISPR Gene Dependency	1.0	2.36252
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.782981
Lef1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.4894
496100420_PCx_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.35415
BRD-K69922285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95801
BRD-K60483981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51676
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K85554193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71915
NB4	DepMap CRISPR Gene Dependency	1.0	4.50315
BRD-K51160592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21407
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_1_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BCL2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37675
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.567055
LRRC59	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16952
BRD-K79635719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03494
PMC10641274-mmc2.xlsx-FOXK1_Untreated-ENSEMBL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118546
BRD-K74399971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05791
Replication fork protection complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.246
A549_BMS-265246_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014277
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.19822
BRD-K82754613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48656
BRD-K71460915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1039
GBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1895
MYNN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01167
GSE126463_4_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6858560-NIHMS1538530-supplement-Supplementary_Tables.xlsx-Supplementary_Table_22-Supplementary_Table_22_Aberrant_Splicing_Events_in_TET2_SRSF2_co-mutated_AML_Patients_from_the_Beat-AML_cohort_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K94116832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24073
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.422117
HOXC12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0451
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.67151
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.23945
GSE140997_4_v_8_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EC-82-LV30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.489175
KA-63-FH23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.379146
GTEx Heart 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	8.87287
BRD-K09131889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32594
LMX1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3659
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0935
A549_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169597
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.5202
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.4688
BRD-K28583191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7108
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258067
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5116
5485_NBR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.648782
BRD-K02778241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15704
9227_TRAF2_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.589733
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.755053
BRD-K50066702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61232
ZNF554	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16746
MCF7_AT9283_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122538
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224068
Paget Disease	DisGeNET Gene-Disease Associations	1.0	null
AC-11-BO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225481
GSE158815_5_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.368326
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227698_5_v_0_g0s2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
GSE159678_4_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE60217_1_v_8_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE192362_1_v_0_erastin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4036
GSE149359_3_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Mast cell_Kidney_Human	CellMarker Gene-Cell Type Associations	1.0	null
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1931
CRCGN008_HEPG2_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23215
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.443259
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.455442
MTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5944
SCC25_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	4.48063
BRD-K76400756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69261
GSE209533_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE238116_3_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10641274-mmc2.xlsx-FOXK1_Untreated-SYMBOL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18685
abnormal spermatogenesis	MGI Mouse Phenotype Associations 2023	1.0	null
SNU1079	DepMap CRISPR Gene Dependency	1.0	3.22523
GSE103068_5_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K04848570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32241
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.347429
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.344538
GSE159678_4_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
9435_TUT1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.736322
CRCGN012_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1034
CAPN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13023
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301898
CRCGN015_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61652
A549_TG101209_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142186
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.729
BRD-K05586628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06788
GSE209582_1_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE143462_0_v_1_omipalisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
M07E	DepMap CRISPR Gene Dependency	1.0	2.63934
GSE242049_1_v_0_txndc5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9961
protein localization to chromosome	GO Biological Process Annotations 2023	1.0	null
GSE210476_2_v_6_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12184404-jitc-13-6-s004.pdf-10-AKAP8L_AKAP8L	Rummagene Transcription Factor Associations 2026	1.0	null
MM253	DepMap CRISPR Gene Dependency	1.0	2.19892
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.5669
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Tazarotene_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00766847
GSE250089_0_v_3_epcam_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88613
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2074
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE76771_1_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ARGFX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8512
HD-18-YL30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209316
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5546
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.419479
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73563
HOXB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7383
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.720476
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K80690345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81619
MCF7_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127071
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.6296
HOXB8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.985
BRD-K05118861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01085
8653_TAF12_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.97761
PMC9336541-Table_3.XLSX-C-vs-H6-L_filter_annot-Unnamed_18_HMX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K26636241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47398
BRD-K88559334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1422
Epsilon DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.846
BRD-K34456337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95061
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.434619
SLC4A1AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25145
GSE193351_1_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE92364_0_v_3_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:B23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5743
BRD-K90769476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07198
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8040704-jcav12p2673s2.xlsx-Up-regulated_genes_in_EBF1-Unnamed_0_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K98444789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.793
BRD-K32722078	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6063
GSE119978,GSE180930_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K84815485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07372
BA-92-CZ75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258019
cinchophen	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02802
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7651
BRD-K45076286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40754
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.96845
IPC298	DepMap CRISPR Gene Dependency	1.0	2.94007
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.669505
PPP2R2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19253
MC-40-IP75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220596
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20110031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25942
LHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22901
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1855
GSE199204,GSE211619_4_v_7_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43922
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.510333
Neutrophil count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.03979
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
3-Benzyloxyaniline	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
GSE202434,GSE202438_7_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119603_1_v_0_oxaliplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ANKRD33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48902
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153354_0_v_1_tcf19_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ORMDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15346
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.6769
BRD-K97934318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03924
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147662_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE211989_3_v_2_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
decreased testis weight	MGI Mouse Phenotype Associations 2023	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0347
BRD-K10876822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42246
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0827
CRCGN015_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13381
HOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1128
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2329
GC-69-JF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316072
P2URK562	DepMap CRISPR Gene Dependency	1.0	2.98329
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9113
BRD-K57833824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61752
GSE171837_3_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K87419143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28482
pre-B acute lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.885
GSE94849_1_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SUGP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0697
BRD-K39328339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4941
DUSP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13131
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2611
BRD-A99402294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41796
CRCGN017_MCF10A.TP53.M_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3797
GSE186440,GSE186443_1_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
9656_USP39_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.17379
BRD-K86025005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56391
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.591883
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.356431
BRD-K58596567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05204
BRD-K01329192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51437
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.645872
BRD-K24337237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65024
BC-09-XQ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212417
GSE231648_4_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ISL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	12.9207
MERO14	DepMap CRISPR Gene Dependency	1.0	2.70511
GSE134029_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE209911_0_v_1_ncstn_human	RummaGEO Gene Perturbation Signatures	-1.0	null
pre-primosome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.215
A549_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0239519
GSE140997_4_v_3_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
9798_BUD23_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.7508
VDR-33458620-PRIMARYEPITHELIAL-HUMAN-PROSTATE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K07551625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88527
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.744016
protein localization to chromatin	GO Biological Process Annotations 2025	1.0	null
NALM-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.94
YY1AP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02603
ADCK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07237
BRD-K82217056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5148
BRD-K34274486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30311
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4937
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.5991
CRCGN013_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.32114
GSE134375_6_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196110_1_v_2_ndrg3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K95792127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71259
GSE171269_1_v_0_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
8157_SMC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.851326
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228962
4116_INCENP_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10841
CRCGN015_HEPG2_48H:B16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34811
PC-68-DU31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301027
SOHLH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59346
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.533295
RBM4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12104
positive regulation of double-strand break repair via homologous recombination	GO Biological Process Annotations 2025	1.0	null
BRD-K72060858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01082
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22718
PRRX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1947
Gliclazide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
AB-21-VE32_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221629
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1059
PMC11227377-2506586.f2.pdf-8-ARID5A_ARID5A	Rummagene Transcription Factor Associations 2026	1.0	null
Mucosa	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
4152_INTS7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.693961
GSE201309_1_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
DNA ligase IV complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.59
CRCGN012_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31357
TOMM20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27829
Xeroderma pigmentosum group B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.224
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9319
GA-47-MH68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24608
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.049
BRD-K06335310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08031
GSE176093_2_v_3_mineral oil_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00889851
BRD-K71644199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87393
GSE111247_2_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.035
Plasma membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.714
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46302
GSE171269_1_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_3_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199255,GSE199356_4_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
protein localization to chromosome	GO Biological Process Annotations 2025	1.0	null
BRD-K90360779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36157
A549_JQ1_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0102024
BRD-K60905390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00271
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN008_HEPG2_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04265
BRD-K36575476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07634
BRD-K92655427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74077
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.32268
BRD-K47510632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04495
Type C thymoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.416
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.09192
Regulatory T (Treg) cell_Liver_Human	CellMarker Gene-Cell Type Associations	1.0	null
MCF7_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130158
BRD-K32906083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86525
BRD-K95651150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0085
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.585926
GSE174498,GSE174500_3_v_4_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.4978
BRD-K45394633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71576
WDR74	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03369
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16807
S1PR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02598
BRD-K35462157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01655
A549_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193902
GSE221327_1_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217552_3_v_5_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
CF-50-QK79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.365581
DNA-dependent protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.068
CRCGN015_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0713
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Rectal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
positive regulation of kinase activity	GO Biological Process Annotations 2023	1.0	null
PMC8948659-ADVS-9-2104491-s013.xlsx-Sheet1-Supplemental_Table_9_related_to_Figure_7_Differential_genes_highly_correlated_with_TP53_deletion_in_H929_cells_by_RNA-seq_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Curcumin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012016
GSE151364,GSE151366_1_v_2_taf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K13146924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9439
EFNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64496
BRD-K86453556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29236
FA-88-II68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23364
GSE203158_0_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE141143_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
mitotic G2 DNA damage checkpoint signaling	GO Biological Process Annotations 2025	1.0	null
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9989
GSE146045_1_v_0_lama3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRCA1-BARD1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.873
BRD-K83300227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2449
GSE140997_4_v_5_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K86746660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71892
BRD-K13697445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20434
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chlorsulfuron	DeepCoverMOA Drug Mechanisms of Action	1.0	0.41
BRD-K46619710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26974
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6363
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4217
RTL8C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18404
GSE216273,GSE216292_14_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_SRT2104_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114224
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2906
SELENOW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49732
STX1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09034
BRD-K71672234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22751
LB-65-SM65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230502
BRD-K98437821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17035
OB-06-WW76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351963
LIMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08348
GSE186647,GSE217288_1_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9807
PRADC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21262
PMC4905481-oncotarget-07-11397-s003.xlsx-Pinin_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K77836949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15132
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H1-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60798
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_2_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
PTPRU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12915
SW620_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.32394
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8221
small testis	MGI Mouse Phenotype Associations 2023	1.0	null
Thymoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
BRD-K18452866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14373
A549_JQ1_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158998
PTPN21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51316
PMC6683136-41598_2019_47363_MOESM2_ESM.xlsx-GENE_SET-Positive_correlation_of_ZEB1-AS1_and_other_genes_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
496100593_TCx_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.93528
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.408563
Nuclear replication fork	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.43
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374457
GSE218727_2_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	1.0	null
1013_C18ORF32_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.525568
6611_PPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.779667
BRD-K28983467	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21879
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.40309
BRD-K87812655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01749
ZNF229	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16631
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K83143868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6832
A549_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140892
BRD-K16518464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18618
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NB-12-ZK38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302197
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7785_SEPTIN2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.593252
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	263.585
MCM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08223
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_5_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HT144SKINFV2	DepMap CRISPR Gene Dependency	1.0	3.87756
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21205
GSE189772,GSE189773_0_v_5_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162384_1_v_0_tfam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8046
Dicyclohexylamine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
CRCGN010_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1599
GSE157904_2_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27418
NE-00-JZ19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235965
K562_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136391
BRD-K22874335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31215
XY body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.431
DCTN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9285
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE81796_0_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
EE-32-EY37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213903
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.454
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289949
EC-01-PH79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271804
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0339
GSE212312_2_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K69238239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.374
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.2722
BRD-K52210941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22447
BRD-K28195874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33098
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.06518
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.4118
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171572_0_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.5867
GSE108614,GSE108615_0_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151090_2_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.63085
Climbazole	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.44
SEC24B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21458
LY2801653	DeepCoverMOA Drug Mechanisms of Action	1.0	0.45
GSE126463_5_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PGR-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169152_3_v_1_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
positive regulation of protein kinase activity	GO Biological Process Annotations 2025	1.0	null
Werner syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
regulation of double-strand break repair	GO Biological Process Annotations 2023	1.0	null
BRD-K86330848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63358
CENPI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15459
CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K36730085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00011
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.444316
K562_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161575
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neck	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.318
CRCGN009_HEPG2_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25927
SB-228357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12739
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.694577
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5556
PMC11615365-41467_2024_54246_MOESM4_ESM.xlsx-RT4-Numb-KD_vs_Ctr-KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K45859834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26356
GSE76425_0_v_10_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K56106571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.315
OA-54-FL10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360112
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.00292
K562_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154992
DMRTC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9102
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7122
GSE111102,GSE111105_1_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_0_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9698
A549_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147309
BRD-K59377703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00435
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-Suppl_Table_6_DEG-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5032
CRCGN009_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7162
BRD-K23553911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13421
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.462639
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.429575
plicamycin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18264
BRD-K00667983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09736
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.1103
ITGA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1365
SMC loading complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.671
LO68	DepMap CRISPR Gene Dependency	1.0	3.81681
BRD-K19930413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53874
CPSF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02652
GSE221327_1_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTV1DM	DepMap CRISPR Gene Dependency	1.0	4.86723
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.947064
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.14759
BRCA1-B complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.931
HOXB9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4862
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.43915
JAK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15566
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.342971
CRCGN010_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8121
CERS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07026
MSANTD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47219
CRCGN016_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.21212
GSE188458_2_v_1_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K30682979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71617
Hmx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.4993
MCF7_Thalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161784
UOK101	DepMap CRISPR Gene Dependency	1.0	2.15184
Meniscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.735
BRD-K16695519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5906
GSE171572_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K70154746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31832
BRD-K24557107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16047
BRD-K96641838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53702
BRD-K22189453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02507
GSE155567_2_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013773
K562_BRD4770_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015853
MRNIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41711
HT3	DepMap CRISPR Gene Dependency	1.0	2.39282
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
5770_NPM1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.595754
VAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6027
BRD-A69950438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02615
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.895985
PCDHB16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50949
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEx AdiposeTissue 20-29 vs 30-39	GTEx Tissue-Specific Aging Signatures	1.0	4.66335
GSE141328_3_v_2_rock2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3947
myclobutanil	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34408
GSE63857_3_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Patupilone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139122
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.455894
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.9978
BC-54-ON71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212982
RAB3GAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58578
GTEx BloodVessel 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	14.7632
BRD-K88274759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34371
Dlx5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.584
BRD-K86855109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9267
HBL-100 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.567
GSE242083,GSE242098_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K97493608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06604
BRD-K76263570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00021
RASAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55072
K562_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0201791
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241587
BB-79-AG41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.493217
TUSC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00502
BC-75-FA82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369381
LMX1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9373
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	108.692
K562_A-366_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184324
ES8	DepMap CRISPR Gene Dependency	1.0	2.47727
GSE127261_1_v_2_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K87776049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18496
GSE217101_0_v_1_mcph1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
decreased litter size	MGI Mouse Phenotype Associations 2023	1.0	null
SHI1	DepMap CRISPR Gene Dependency	1.0	2.28696
BRD-A55574211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06804
GTEx AdiposeTissue 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	14.7581
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
AC-30-XU83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295525
HOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5724
GSE112860_5_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92085
6549_POLR2H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.990793
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF148	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59119
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326318
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.735783
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.53841
LIVF001-008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27404
PMC7203476-Table_2.XLSX-MI_treat_vs_control-Unnamed_0_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
OE-75-WF43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208922
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24034
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE182680,GSE182683_5_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K79965790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09441
GE-34-TW62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220537
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23731
BRD-A03997826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29547
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.59218
7423_RPAP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.541096
BRD-K85633971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46799
BRD-K60166659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68238
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FA-80-DR66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215212
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3117
MCF7_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139841
EE-98-PF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229022
BRD-K76985713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23036
BRD-K02882086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28028
GTEx Heart 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	1.0	3.1135
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.613588
PMC7825356-8844261.f3.docx-13-PROP1_PROP1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.99015
BRD-A61522392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34776
GSE245270_1_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
MEOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8276
BRD-K75037209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09017
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.395643
BRD-K30491662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03695
regulation of protein kinase activity	GO Biological Process Annotations 2023	1.0	null
BA-77-US35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326383
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358672
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K76829357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45688
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_decrease_in_MLL-AF4_ChIP-seq_signal_2198_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Tofacitinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.33
GSE245270_1_v_0_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
NDUFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06415
BRD-K39342915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65124
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9617
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289028
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7996
SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.01069
BRD-K70843862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34812
regulation of double-strand break repair via homologous recombination	GO Biological Process Annotations 2023	1.0	null
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K43205312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8609
BRD-K45713337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56716
BRD-K95578456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3416
BRD-K83370434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35177
Basimglurant	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161771_2_v_1_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.2974
CDC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23145
7478_RPL7L1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.689853
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.25
WD-97-SF27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235346
BRD-K69791255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11639
NCIH2066_LUNG	CCLE Cell Line Proteomics	1.0	2.51852
GSE143944_2_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.414098
HOXA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1992
GSE220520_1_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
YAMATO	DepMap CRISPR Gene Dependency	1.0	3.08565
GSE236228_0_v_1_penfluridol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE220520_5_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K45537529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51573
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285263
GSE235550_2_v_0_hspa9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Tie2 kinase inhibitor_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213312
4593_LIN52_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578519
BRD-K93613839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29079
BE-04-AN21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245375
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21589
BRD-K28982281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20479
QB-69-QH67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224013
SKMEL2_SKIN	CCLE Cell Line Proteomics	1.0	3.68333
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174683
DOHH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45726
BRD-K83209781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45044
Synaptonemal structure	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.787
GSE224311_3_v_1_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4728
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6858560-NIHMS1538530-supplement-Supplementary_Tables.xlsx-Supplementary_Table_21-Supplementary_Table_21_Aberrant_Splicing_Events_in_TET2_SRSF2_co-mutated_AML_Patients_from_the_TCGA_cohort_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN009_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58067
MCF7_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129813
IC-43-CV07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297035
GSE140651,GSE140653_2_v_6_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3698
BRD-K26402831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82738
GSE213228_1_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0100818
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7853
KHSRP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24619
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.734111
mitotic DNA damage checkpoint signaling	GO Biological Process Annotations 2023	1.0	null
BRD-K32759631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07666
A549_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145046
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8804
GSE171837_1_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9601604-NIHMS1841143-supplement-SuppTable-2.xlsx-FOXO3-specific_targets-FOXO3-specific_targets_1218_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE198165,GSE198166_9_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.595837
TFG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04905
GSE102505_5_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.68222
BRD-K73014869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66456
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.2718
mitotic G2 DNA damage checkpoint signaling	GO Biological Process Annotations 2023	1.0	null
chr5_179834592_G_A_b38	GTEx eQTL 2025	1.0	3.01163
GSE246053_4_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE81796_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
U2AF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32504
BB-23-PM31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.351341
BRD-K58586013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10975
BF-02-AC35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208189
GSE201877_1_v_0_yap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226285_2_v_0_nr0b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.78804
OCUG1	DepMap CRISPR Gene Dependency	1.0	6.40373
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_1_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8235
OF-47-EQ74_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28119
CRCGN016_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6702
BRD-K50943704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48905
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25091
BRD-K01296372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29363
GSE102505_6_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PC-87-OG75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232714
Parathyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K36961619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4886
SA-53-XG95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22289
BRD-K25138450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35694
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.68741
Trunk	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.4429
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.2301
WC-95-BX35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224938
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.5575
BRD-K89333198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56272
Replication fork	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.683
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
GSE104508_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K00411149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31634
ractopamine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12372
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.454756
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2595
BRD-K96265882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20608
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.742179
CRCGN015_MCF10A.WT.HP_24H:H11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1315
Small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.049
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5696
8621_SYMPK_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.50181
ANKRD50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23727
BRD-K85271599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77858
BRD-K80761625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18761
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5893
GSE214685_0_v_1_nsun2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
regulation of double-strand break repair via nonhomologous end joining	GO Biological Process Annotations 2023	1.0	null
BRD-K62325456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12644
GSE57875_1_v_0_hnrnpl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.725595
GSE171292_1_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206226_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_3_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.661623
A549_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209098
PEA1	DepMap CRISPR Gene Dependency	1.0	9.81316
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Uterine endometrium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE182680,GSE182683_10_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
LE-40-JW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213672
BRD-K11844807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01231
GSE225218_0_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
EML2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01212
BRD-K20437312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25938
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.776862
2204_DHX16_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10889
K562_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207377
MCF7_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138617
NKX6-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.7724
SRY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.7857
bleomycin-sulfate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02986
PMC9314667-Table_1.xlsx-Regulons-TFAP2A_TFAP2A	Rummagene Transcription Factor Associations 2026	1.0	null
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6699
AC-49-NG46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20548
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.502314
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.51097
A549_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015419
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8567
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.626
EPS8L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00181
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.863053
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7737
GSE123825_0_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
eb185	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.926
GTEx AdiposeTissue 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	1.0	12.1518
GSE107854_2_v_0_prmt5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156168
GSE206270_2_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77178_5_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175198
HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4753
BRD-K94445007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67127
GSE217441,GSE217443_1_v_0_ivosidenib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Intracellular anatomical structure	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K77074748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01403
Hnf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	58.2882
MCF7_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155773
TD-48-XJ84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236439
POMGNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01067
GSE210682_2_v_1_methadone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
9972_ZBTB16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.573488
GSE146074_9_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177366
Cellular anatomical entity	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.522854
7505_RPS16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.937227
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.684
2792_EXOSC5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.696824
10029_ZC3H8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.33882
AAAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1079
GSE102467_1_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.434217
Kaempferide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
LIVF001-021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18203
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-07-LL18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.436567
AF-67-LZ82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247685
BARHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5549
BRD-K07009788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10671
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.999269
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.664568
C1orf226	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2429
9400_TTK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.585038
CRCGN017_MCF10A.TP53.M_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2045
positive regulation of kinase activity	GO Biological Process Annotations 2025	1.0	null
GSE86507,GSE86509_0_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K24471810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82559
BRD-K97470305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82415
GSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7748
LRRC73	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35553
R2TP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.267
BRD-K88996011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05292
TB-06-VB30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20313
BRD-K68078571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02917
BRD-K96320811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04394
Replisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.323
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9738
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4784
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-LEF1_UP_V1_DN-Gene_name_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE245134_0_v_1_atg5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Decitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.010997
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2206
DA-69-UN88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24765
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.7507
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE207135_2_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9534852-41598_2022_20572_MOESM4_ESM.xlsx-Sheet1-Supplementary_Table_S4_Transcriptomic_data_related_to_AHR_function_considered_for_metabolic_reconstruction_model_generation_AHR	Rummagene Transcription Factor Associations 2026	1.0	null
CPSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21146
MSLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29066
MCF7_S3I-201_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147502
BRD-K98560805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06676
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE180789_1_v_0_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of double-strand break repair via homologous recombination	GO Biological Process Annotations 2025	1.0	null
UTP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06754
BRD-K13564884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15466
BRD-K20520611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07365
BRD-K73051782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35571
TC-95-IR96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210269
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8216
PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
positive regulation of protein phosphorylation	GO Biological Process Annotations 2023	1.0	null
ZNF35	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8362
TFDP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07627
GSE188458_2_v_4_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.614955
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7254
CRCGN017_MCF10A.WT.HP_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2847
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.323209
reduced male fertility	MGI Mouse Phenotype Associations 2023	1.0	null
positive regulation of double-strand break repair	GO Biological Process Annotations 2025	1.0	null
GSE94814_2_v_3_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193751_1_v_3_oridonin_human	RummaGEO Drug Perturbation Signatures	1.0	null
LB-65-SM65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242251
ATOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48649
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Anchored component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.587
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320888
BRD-K93615384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15255
PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ensembl_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
TLK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24782
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1784
GSE182680,GSE182683_5_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
RB-34-TO07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.438935
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6688
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265635
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.516
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118077_4_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SGTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72369
CRCGN015_MCF10A_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9299
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27819
ATRkd cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.438
BRD-A40022950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1627
BD-61-OO16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205159
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.703703
PMC10290283-biol-2022-0622-sm3.pdf-124-ZFP1_ZFP1	Rummagene Transcription Factor Associations 2026	1.0	null
1605_CHTF8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.47584
GSE232631_4_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6172843-13059_2018_1523_MOESM6_ESM.xls-Sheet1-Table_S5_mRNAs_variation_abundance_1_5-fold_in_YBX1-knockdown_BGC-823_cells_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
1165_CAMKK2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519502
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.757504
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2138
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.435933
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
GSE180377_2_v_1_lipa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DU4475	DepMap CRISPR Gene Dependency	1.0	8.25093
Slx1-Slx4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.321
GSE126776_2_v_1_pelp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195713_0_v_1_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14445
SMARCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26938
GSE132386_2_v_0_ppara_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_10_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRCA1-C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.617
BRD-K03339354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94757
496100588_TCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.55388
BRD-K33689641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09579
BRD-K86867503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04876
XB-53-OZ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.334868
TRPS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7363
GSE128730_4_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11933697-41467_2025_58216_MOESM8_ESM.xlsx-SD6_ATF3_EV_NS1-SYMBOL_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K45013233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72058
BRD-K95591068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10591
KD	DepMap CRISPR Gene Dependency	1.0	2.35719
BRD-K49659981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02238
GSE126463_4_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128730_7_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125014_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CLINDAMYCIN-PO4	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16782
ESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4609
PMC5195898-NIHMS825571-supplement-3.xlsx-Sheet1-H1975_M1_vs_H1975_M1_CIC_reconstitution_Differential_gene_expression_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144834
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.60963
Frontotemporal Dementia	DisGeNET Gene-Disease Associations	1.0	null
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.5444
BB-11-JI42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204785
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.06556
cyclocytidine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88166
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.8562
BRD-K93624320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11314
PAX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4514
BRD-K24946605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09091
GSE226584,GSE226589_1_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K65831955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05451
OTX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9067
HOXC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21652
BRD-K44494409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82281
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7332
BRD-K84613654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83518
GSE182680,GSE182683_5_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282985
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE129389_0_v_4_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LAMA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11866
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292136
AA92593	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.7
LHX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.904
response to ionizing radiation	GO Biological Process Annotations 2025	1.0	null
MDAMB453_BREAST	CCLE Cell Line Proteomics	1.0	6.7411
Lateral element	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.836
SDR39U1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03134
Lattice corneal dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
ICC2	DepMap CRISPR Gene Dependency	1.0	3.42612
GSE208171_0_v_1_zc4h2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Dmrt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.2097
CRCGN013_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81594
GOLT1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24781
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
1040_C1ORF131_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.10867
A549_PD98059_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146869
RNA polymerase I complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.971
GSE125219,GSE125221_4_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294197
BRD-K72647169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03205
BRD-K37625653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72861
GSE148066,GSE157787_0_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K89264608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46519
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01878
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.405564
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K40548004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19479
KINGS1	DepMap CRISPR Gene Dependency	1.0	4.12484
BRD-K28559679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31066
BRD-K32882942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54012
DNA damage response	GO Biological Process Annotations 2023	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.57855
Pentamidine (isethionate)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0240688
Uterus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN011_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7352
BRD-K79997957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2077
AE-52-NW93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.330371
BRD-K65910757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13043
HD-19-IW09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224877
496100334_PCx_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16188
BRD-K76611906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02021
CCC5	DepMap CRISPR Gene Dependency	1.0	4.574
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.321978
GSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4712
response to ionizing radiation	GO Biological Process Annotations 2023	1.0	null
BRF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07463
HOXD10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.185
MCF7_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176542
ZNF578	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62412
BRD-K98465548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17297
KLHDC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6436
GSE140651,GSE140653_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143406_1_v_0_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.93926
BRD-K97595801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73361
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5185
IGBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3235
BRD-K88000297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06619
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ABCD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66024
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0451
CRCGN015_HEPG2_48H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.28049
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K67896259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72404
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K82671459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34112
YA-85-VH07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262182
BRD-K79995507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32084
GSE134029_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K93998074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57246
JF-30-FW92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.342177
BRD-K69715817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29129
GSE186287_1_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61395
GSE70935_3_v_5_cyfip1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71309
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06982
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345309
GSE248858_5_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K15282657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15481
Selisistat	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.52
GSE221327_10_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE85302_0_v_1_kat6a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
RAG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30423
KKU100	DepMap CRISPR Gene Dependency	1.0	4.40616
GSE226397_0_v_1_cystine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_10_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZYG11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12953
OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.1227
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.475963
BRD-K79347397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71623
GSE196318_0_v_1_xpo4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXD12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1066
A549_Panobinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00943752
MTHFD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44066
GSE93309_2_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GA-04-JM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.506992
MCF7_Tacedinaline_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142084
BRD-K22443456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08617
K562_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148446
BRD-K77203880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09648
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ALKBH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27839
A549_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014608
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6183
PMC8185471-mmc4.xlsx-D4-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_4_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
GSE216043_11_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K31672963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04642
NOTO	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0318
ASNS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09771
GTEx Esophagus 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	15.161
KIAA0319L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08006
NDUFA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05182
MCF7_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147936
positive regulation of DNA recombination	GO Biological Process Annotations 2023	1.0	null
GSE216043_11_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.641622
Nijmegen breakage syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.113
BRD-A66025870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55344
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211177,GSE211178_4_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PF-59-CY33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.563384
CRCGN008_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.68565
BRD-K22800340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21946
AB-12-PP61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265889
CRCGN014_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3698
PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-gene_name_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BB-42-FF52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.378299
CRCGN013_HEPG2_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22319
GSE48812_9_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184356_3_v_0_tfam_human	RummaGEO Gene Perturbation Signatures	1.0	null
Site of double-strand break	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.091
regulation of double-strand break repair	GO Biological Process Annotations 2025	1.0	null
CMTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26169
GSE158320,GSE183351_2_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210101,GSE210114_5_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE190186,GSE190188_0_v_5_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE124920_1_v_2_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A77907596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04989
496100658_FWM_probable Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.51656
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KC-32-GO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238716
GSE166317_3_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.9931
CRCGN016_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.84235
BRD-K17895004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19974
GSE140997_4_v_6_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.380244
CDC25A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0125
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context3-Nearest_Ensembl_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162782
CRCGN013_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.89114
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCT6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13393
HOXB7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3745
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.655361
BRD-K41717398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27493
BRD-K29903367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14533
GSE209898,GSE209899_0_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE200839,GSE233826_2_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K19764912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17826
5732_NOL10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01224
Delta DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.885
MRS 1754	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
BRD-K72336314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0222
7498_RPS10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.794884
CRCGN015_MCF10A.TP53.M_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73945
BRD-K48299239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44931
CB-87-RB49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.314753
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K48235533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07603
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8561
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE159049_3_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K54650634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14163
GSE171177,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.3925
BRD-K04695993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75355
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K34954550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03053
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169298
GSE199606_5_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K95672029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92896
BRD-K75869048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20428
BRD-K41433616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22505
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_4_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
PPP1R12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.47981
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9
BRD-K60644933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14194
PMC11615365-41467_2024_54246_MOESM4_ESM.xlsx-RT4-Numb-KD_vs_Ctr-KD-ensemblGeneId_AR	Rummagene Transcription Factor Associations 2026	1.0	null
mitotic DNA damage checkpoint signaling	GO Biological Process Annotations 2025	1.0	null
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K63212062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4816
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53829
NDUFS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16656
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.513031
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K93396907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16082
GSE188570,GSE188571_3_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271157
TMEM214	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.038
BE-73-KD75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.332952
BRD-K99452971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98682
BRD-K31222955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13221
CRCGN015_MCF10A.TP53.M_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1175
BRD-K73110675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13858
CRCGN013_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.05405
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.06736
A549_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135068
HES1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00646
BRD-K36055854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00536
BRD-K89364982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1928
GSE62292,GSE62295_2_v_0_col4a3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188578
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69375
Nuclear replisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.223
BRD-K66963616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51689
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226249_0_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K87023633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44158
BRD-K39101193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23711
positive regulation of double-strand break repair	GO Biological Process Annotations 2023	1.0	null
Dense fibrillar component	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.551
BRD-K86946907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87362
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LRFN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.24042
BRD-K86893953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59711
A549_Ofloxacin_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.013586
Nucleolar chromatin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.597
HOXA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.978
Throat	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.514987
GSE223893_2_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K94962942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03104
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3701
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.564505
K562_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189861
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K94439911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65627
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.802
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.269215
GSE203267_0_v_1_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186287_2_v_0_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186647,GSE217288_11_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1183
MON	DepMap CRISPR Gene Dependency	1.0	3.48731
GSE230573_1_v_0_dcaf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4905481-oncotarget-07-11397-s003.xlsx-CtBP1_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.99245
BRD-K50432649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5173
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220844
PMC12172627-NIHMS2085635-supplement-5.xlsx-E2F1_GENIE_Results-Unnamed_1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.89517
DC-22-OP01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.31095
BD-81-LB65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24658
TUHR14TKB	DepMap CRISPR Gene Dependency	1.0	4.0193
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6912
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.501526
BRD-K31021810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0043
GSE118617,GSE118619_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K46561246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9315
BRD-K09454191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07381
SPDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44793
TEAD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1083
BRD-K85813125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46517
BRD-K70050144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06223
EA-22-SB72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227313
GSE130383_2_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199255,GSE199356_4_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159893_2_v_1_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
ED-02-CL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333593
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.655359
BRD-K85659077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02668
CRCGN008_HEPG2_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2069
GSE231648_0_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5058748-oncotarget-07-31177-s002.xlsx-ZNF224_gene_peaks_promoter-Table_S3_Genes_that_contain_a_ZNF224_enriched_region_within_1_kb_of_the_transcription_ZNF224	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-fig-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE155567_1_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	1.0	null
XPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63059
XEN445	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.21
GTEx BloodVessel 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	10.3886
BRD-K82562625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85491
GSE193351_1_v_2_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.04611
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.71557
GSE147056_2_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.586835
regulation of double-strand break repair via nonhomologous end joining	GO Biological Process Annotations 2025	1.0	null
Cohesin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.274
GSE231648_0_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K28122619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57875
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.601234
CB-24-AT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.491263
GATA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9456
BRD-K12841150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11401
GSE171292_6_v_0_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_31_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210101,GSE210114_6_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K31372389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02882
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.663584
GSE231891_5_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
2105_DDX18_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05347
CRCGN010_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3135
GSE215351,GSE215794_1_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEx Heart 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	7.48529
GSE155830_1_v_0_fkbp5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_SNS-314 Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140672
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K14181473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27231
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312688
496100394_TCx_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00759
Organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
A549_Resveratrol_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140397
GSE197630_1_v_0_ruvbl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal seminiferous tubule epithelium morphology	MGI Mouse Phenotype Associations 2023	1.0	null
DA-54-NN76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21719
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.349606
6542_POLR2C_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.630415
GSE138019_4_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3828
ATP5F1E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42561
BRD-K73459389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21071
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8040704-jcav12p2673s2.xlsx-Up-regulated_genes_in_EBF1-Unnamed_5_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K69960043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63734
GSE102505_4_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58584
Ribonuclease MRP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.622
CRCGN015_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49407
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.555627
BRD-K87647164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08803
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.02175
GSE141328_1_v_0_rock2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context3-Gene_Name_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
LBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6241
GSE213228_2_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.464043
BRD-K89853033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35041
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3-Deazaneplanocin A	DeepCoverMOA Drug Mechanisms of Action	1.0	0.63
BRD-K93817456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47401
GSE169152_5_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348561
BRD-K87666020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13711
BRD-K81619018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86285
GSE147056_0_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Senicapoc	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
BRD-K71758378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78349
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.2175
GSE216043_3_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102505_4_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.16061
GSE113734_1_v_2_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K63587749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41205
MCF7_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130768
3573_GTF2H1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.2704
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7737
GSE148096_1_v_0_erlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-27-BW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.077
SOX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7957
PMC5985538-mmc2.xlsx-selected_2X_in_2_exp_SALL1_FL-Gene_names_SALL1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10870497-13046_2024_2976_MOESM10_ESM.pdf-5-FOXD4_FOXD4	Rummagene Transcription Factor Associations 2026	1.0	null
NCK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04281
CEP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00186
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PLOD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40105
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27337
HOXA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9785
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.669767
BRD-K45677957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45799
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135350_2_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K83463455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.42402
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5396
BRD-K96417480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62147
BRD-K45498945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04962
Thyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
pre-B-lymphocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.057
K562_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156121
MEL-JUSO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.727
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.029
GSE229671,GSE229673_3_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K43852369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24072
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.882058
ZNF574	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02892
BRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7019
BRD-K24977393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31777
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73355908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51311
NCIH28	DepMap CRISPR Gene Dependency	1.0	2.25897
GSE161064,GSE161065_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243544
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.63053
Mre11 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.205
RPS3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46345
SC-25-HE80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284749
VSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9539
BRD-K42400613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07192
CC-55-CD84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296695
GSE164874_5_v_12_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228549
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.3638
GSE140997_4_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
3626_HAMP_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.614082
GSE160246_0_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K84956158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46121
GSE179002_4_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IC-05-AW29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386039
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE226285_3_v_0_nr0b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100641_PCx_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.11295
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.605982
FA-47-IB34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.36816
MCF7_PFI-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153418
GSE215109_0_v_2_ep400_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_0_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Roxatidine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.22
BRD-K73802986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21823
HOXC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1456
BRD-K62148271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70241
GSE169152_3_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.413
Proctitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.473
BRD-K85977570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20216
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.327173
BRD-K43431234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58701
SFXN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25554
SBC5_LUNG	CCLE Cell Line Proteomics	1.0	2.66611
AD-00-WA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.474259
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
BRD-K43570522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87464
positive regulation of double-strand break repair via homologous recombination	GO Biological Process Annotations 2023	1.0	null
GSE95685_2_v_5_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SOX12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5929
CRCGN016_MCF10A.WT.HP_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47147
GSE113734_3_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	1.0	null
mitotic G2/M transition checkpoint	GO Biological Process Annotations 2023	1.0	null
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K39705203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33821
NCIH446_LUNG	CCLE Cell Line Proteomics	1.0	3.74028
COQ7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84372
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.504163
AC-84-QG99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229173
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.528317
GSE169713,GSE169715_1_v_2_tert_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CE-37-XI06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248289
GSE158632_3_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186440,GSE186443_4_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
KE-73-XV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283271
BRD-K79494396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5217
MCF7_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170888
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.322658
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221298
Membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.714
SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4981
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21068
MCF7_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156368
GSE200839,GSE233826_5_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
SOX13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9699
BRD-K40674409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09478
MCF7_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126802
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3234
GSE199606_5_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8594
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.963311
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232056
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.07605
Cell periphery	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.714
GSE182680,GSE182683_10_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCT-8 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.954
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	151.247
Rad17 RFC-like complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.145
CHMP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70365
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307937
BRD-K82774801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67103
BRD-K85525164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58412
MCF7_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220526
BRD-K63919349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44103
MCF7_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147702
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6702
BT16	DepMap CRISPR Gene Dependency	1.0	2.70997
GSE159678_4_v_7_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K96288607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10243
GSE185139_1_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K12824862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24527
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K30361950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90863
Meiotic cohesin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.615
BRD-K72807299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03579
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.897339
327_ANKRD13A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.518648
BRD-K16093370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74764
CRCGN012_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28339
BRD-K10635555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02429
GSE240258_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4774
GSE169152_3_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.37038
GSE229914_1_v_3_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123825_0_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BE-42-IC00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275618
BRD-K35222206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48483
AD-51-FB60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205276
positive regulation of protein kinase activity	GO Biological Process Annotations 2023	1.0	null
Amoebocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.546
8185_SMNDC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.564673
GSE221327_10_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE102505_1_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.82452
GCM2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.542
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE48812_4_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Arid3b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.5944
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.820047
GSE227698_2_v_1_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
2728_ESCO2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.693666
HA-22-CY42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201284
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	2.87679
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.76814
CA-10-RU23_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202021
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24405
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE182680,GSE182683_5_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K55814495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03478
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CA-66-FY97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.447306
chr5_179831901_G_A_b38	GTEx eQTL 2025	1.0	1.99969
MCF7_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218323
hyperactivity	MGI Mouse Phenotype Associations 2023	1.0	null
MEOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7182
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8344
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
6866_PSMD12_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.50057
AC-97-KP88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333507
TF-04-RX73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296226
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0806
Site of DNA damage	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.018
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.5746
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-LEF1_UP_V1_DN-Ensemble_gene_ID_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73402542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03097
GSE79291_1_v_2_streptozotocin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239436,GSE239441_0_v_1_keap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AE-07-IZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.305847
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.389
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6068
SOX14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5717
MPND	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55509
4950_MED27_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.95678
MCF7_Sorafenib Tosylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176016
SEC31B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13363
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.599
Alx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.5794
BRD-K80819226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19457
GTEx BloodVessel 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	19.9897
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.1628
6874_PSMD6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04581
AF-41-QY60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.27267
BRD-K28656917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42559
BRD-K42367391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12981
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.8042
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K34169251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1532
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PC3_PROSTATE	CCLE Cell Line Proteomics	1.0	2.19161
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K15713104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0465
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE231648_4_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MED12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17955
BRD-K58932103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09367
ENY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12974
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K82967678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14011
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.479394
GSE142210_2_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221327_6_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
EC-71-PH39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21983
BRD-K73769678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02235
BRD-K75625428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00351
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8567
GSE145445,GSE145454_0_v_1_cop1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7834_SF3A3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.26278
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6209
GSE160246_9_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K14909006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0946
GSE188570,GSE188571_3_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149903_4_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K74324157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09443
BRD-K06029218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44775
HOXB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2348
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.824818
BRD-K32018176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29113
GSE60217_1_v_10_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.712766
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE134375_0_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
DC-23-UM36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240206
ZHX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52253
DD-74-PJ26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234635
GSE169356_0_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K20586104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03967
BRD-K44858727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23897
chr5_179835233_T_C_b38	GTEx eQTL 2025	1.0	1.96345
XA-12-UL84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.366304
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2791
KB-78-BE93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270974
ATR-ATRIP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.961
CRCGN017_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.94758
BRD-K93268593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19299
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K59491389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34832
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0816
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	75.1325
1486_CENPM_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.664023
Thymus cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
BRD-K30581008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35223
BRD-K17245631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25471
MCF7_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156206
BRD-K05070188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00876
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.35334
NDUFS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37688
GSE143955_1_v_2_ripk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K96280720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41884
DF-75-OU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.342133
A549_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178553
GSE80098,GSE80366_0_v_8_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.831155
GSE155567_3_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.254
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.45405
CRCGN008_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.41085
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3535
GSC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0042
DNA replication factor A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.032
8227_SNRPC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.638391
GSE245270_1_v_5_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRCA1-A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.943
PSMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07272
positive regulation of protein phosphorylation	GO Biological Process Annotations 2025	1.0	null
DD-43-WW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.452057
BRD-A94740628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40646
PBXIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10125
GSE171292_5_v_2_ehhadh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4842
BRD-K80965028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19433
MCF7_Glesatinib(MGCD265)_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0105619
BRD-K83438939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09991
HEATR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01217
BRD-K97707303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.22947
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE221327_10_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374293
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.462031
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156465
AB-18-YN11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.449029
PMC3419980-leu201249x2.xls-RUNX1-ETO_siRE_ChIPSeq_peaks_ge-gene_name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160304,GSE163392_0_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K88485670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86749
GSE149123,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF883	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18231
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HEC59_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	2.34748
CRCGN009_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31355
BRD-K92311828	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13791
TE-26-XS06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206187
3573_GTF2H1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519502
BRD-K37269981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22111
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.641328
CC-68-YZ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.545188
ME-31-RM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221329
GSE171572_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
VAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2241
HS944T_SKIN	CCLE Cell Line Proteomics	1.0	2.14749
496100670_TCx_probable Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.23569
CRCGN017_MCF10A.WT.HP_24H:P18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0749
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.376187
Dlx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.4787
BRD-K50961262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71282
BRD-K90231936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21884
BRD-K73479560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27477
GSE149621_0_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.70246
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100396_HIP_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12847
GSE209898,GSE209899_0_v_1_flcn_human	RummaGEO Gene Perturbation Signatures	1.0	null
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.38567
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE134029_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DNA damage response	GO Biological Process Annotations 2025	1.0	null
SNU1079_BILIARY_TRACT	CCLE Cell Line Proteomics	1.0	5.57286
BRD-K24133999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21295
GSE211128_2_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
SINHCAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21824
4955_MED4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.533687
BRD-K33128056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07458
HMBOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3506
LHX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8164
GSE206870,GSE206872_3_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE232944_1_v_0_ctnnb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2092
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4318
BRD-K87748094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24188
BRD-K37506332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77033
PPIL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30924
BRD-K90127029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03618
MCF7_Fluorouracil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125058
BRD-K98625375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3877
GSE223908,GSE223909_1_v_3_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-30-XU83_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301071
HCC1806_BREAST	CCLE Cell Line Proteomics	1.0	2.04565
NBTGR	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.2
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mitotic G2/M transition checkpoint	GO Biological Process Annotations 2025	1.0	null
Thymus gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.138
GSE249544,GSE249637_9_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TRAIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46739
SW954	DepMap CRISPR Gene Dependency	1.0	3.98251
S0-EE-U3YG_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337434
GSE176008_0_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EFCAB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22551
BRD-K19327124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15629
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.3436
GSE211128_4_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
F5	DepMap CRISPR Gene Dependency	1.0	5.36671
AE-38-LX10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225173
BRD-K18686200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46844
CRCGN017_MCF10A.WT.HP_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04875
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.489638
HOXC9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9966
HC-01-FD24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312375
CENPQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23011
BRD-K88671309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53474
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7006
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.480887
GSE134375_4_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211128_7_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
HC-01-FD24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.485255
496100585_PCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00304
BRD-K92879007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.32092
Nuclear lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN017_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.066
CMTM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36851
BRD-K47890395	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39006
positive regulation of DNA recombination	GO Biological Process Annotations 2025	1.0	null
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	1.0	null
oligozoospermia	MGI Mouse Phenotype Associations 2023	1.0	null
GSE151090_0_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46913
BRD-K34262858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03441
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7576810-41419_2020_3099_MOESM9_ESM.xlsx-MS_analysis_EVI1-WT_vs_EVI1-S43-Unnamed_0_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146982_7_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.45815
GSE128730_7_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
protein localization to chromatin	GO Biological Process Annotations 2023	1.0	null
BRD-K53896147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41154
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4128
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
BRD-K84387578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22136
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE181003_3_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC38	DepMap CRISPR Gene Dependency	1.0	3.67992
GSE186647,GSE217287_1_v_3_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95077_1_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_5_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K79568363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00565
regulation of protein kinase activity	GO Biological Process Annotations 2025	1.0	null
CRCGN008_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24915
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.674102
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_1_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
TUBGCP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.095
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.339353
GSE169205_0_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4126
CD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09241
HOXC8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1536
K562_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150951
CRCGN009_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.37282
GSE223893_11_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K82364958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04062
NCIH1573	DepMap CRISPR Gene Dependency	1.0	2.70368
LHX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.941
PMC6742760-41467_2019_12079_MOESM10_ESM.xlsx-Data_S8-Supplementary_Data_8_Target_genes_of_FOXA1-bound_enhancers_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	92.3345
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.617114
BRD-K71625503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00702
10255_ZNF274_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.520361
HPGDS-In1	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
GSE164874_5_v_7_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K27398402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21876
DE-30-UR76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247445
BRD-K48020855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06881
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CA-68-TC79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200415
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.0245
K562_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017817
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4576
GSE179031_3_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K82765368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12268
BRD-K10590495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56457
6104_PBX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.567884
BRD-K13461720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65735
ZBTB32	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2151
JHUEM1	DepMap CRISPR Gene Dependency	1.0	6.36994
GSE182680,GSE182683_5_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.9524
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5758
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.64655
GSE209938_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.56766
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.0325
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.2194
MEF2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.687
carboplatin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11796
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.32486
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Congenital hypoplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
GSE254517_3_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.93006
abnormal chromosomal synapsis	MGI Mouse Phenotype Associations 2023	1.0	null
Arid5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.6278
CD-20-GE75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216684
BRD-K97368902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20053
GSE140651,GSE140653_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-30-CR11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.395583
BRD-K02471501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11966
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.805637
GSE242049_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.50882
GSE247862,GSE247863_4_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27615
TAF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81304
BRD-K59893572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71474
GSE157594_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAP3K20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24815
GSE146074_0_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bladder	GTEx Tissue Gene Expression Profiles 2023	1.0	3.17161
GSE201110_0_v_1_sirt4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
4951_MED28_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.632
A549_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186829
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6744
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3373
GSE202434,GSE202438_10_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217382
MCF7_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147011
BRD-K06049932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.422
GSE188570,GSE188571_5_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283804
HB-92-PE54_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218835
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.545301
7424_RPAP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.995597
BRD-K42799692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92578
BA-95-YU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.358552
BRD-K32269272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54777
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
GSE231648_1_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K03070961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52865
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.13167
GSE139455_7_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6389
Paraspeckles	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.823
POU2F1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K21753319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0251
CRCGN011_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43595
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
ANAPC15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33698
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
P granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.717
small seminiferous tubules	MGI Mouse Phenotype Associations 2023	1.0	null
MTG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37677
AD-52-UZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.368206
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.216
decamethonium	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27902
DA-10-HD17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282003
BRD-K77884956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14115
GSE60217_1_v_7_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K64665523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22748
BRD-K72351789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3307
BRD-K72549552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.25931
GSE60217_1_v_9_inosine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATAD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69436
HOXA7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.0079
BRD-K58892587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07526
BRD-K83553001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34952
CRCGN013_HEPG2_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36345
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.379695
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8396
BRD-K76664579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36683
nucleus	GO Cellular Component Annotations 2023	1.0	null
LC1SQ	DepMap CRISPR Gene Dependency	1.0	6.1394
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ENSG_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285002
PMC7857731-elife-63093-supp1.xlsx-DEG_MITF-X6vsEV-SkMEL28-Unnamed_2_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352819
Paget disease of bone	ClinVar Gene-Phenotype Associations 2025	1.0	null
BC-54-ON71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.509662
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.329433
BRD-K98541397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42262
GSE112860_3_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223893_2_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WM1799_SKIN	CCLE Cell Line Proteomics	1.0	4.14598
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205913_1_v_0_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Fanconi anaemia nuclear complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.695
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1861
GSE102505_5_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
YF-00-IN39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.727788
PMC7821388-DataSheet_3.xlsx-MYBL2_DDR_ChIPseq_Analysis-Gene_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9296
GSE213228_4_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PGF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54374
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7251
BRD-K58883090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86999
BRD-K82930531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17997
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.463037
LIVF001-027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16173
OGDHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31535
BRD-K82791632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23374
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.403818
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7795
asthenozoospermia	MGI Mouse Phenotype Associations 2023	1.0	null
TSPAN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10218
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE171269_1_v_4_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Sonidegib_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0155242
TRPC4AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13403
BRD-K78902613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6361
CRCGN017_MCF10A.TP53.M_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65747
GSE145249_1_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	-1.0	null
smc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.678
CRCGN014_HEPG2_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26263
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232286
CRCGN015_MCF10A.TP53.M_24H:G22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2316
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2941
VSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7659
GSE126504_0_v_1_hpse_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K39499927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1279
496100575_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.43272
Levosimendan	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE146982_7_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Spironolactone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
BRD-K87595216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30426
BRD-K78363521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4132
BRD-K15123815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48795
BRD-K74317118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06357
BRD-K68162101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47692
Nucleoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226249_0_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE147626_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136046
BRD-K91387865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05647
A549_Quercetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156956
HC-11-RK51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225203
BRD-K87044635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02769
HNF4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85938
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7644
PMC10944835-41467_2024_46639_MOESM4_ESM.xlsx-SD17-Supplementary_Data_17_Differentially_expressed_genes_according_to_homozygous_genotype_at_the_TWIST1_locus_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
FKBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46059
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE198165,GSE198166_8_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.16359
BRD-K02106348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02878
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K67531128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93516
BRD-K96106084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28818
GSE220520_3_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE108614,GSE108615_3_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6862_PSMC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.539323
BRD-K80736363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43507
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K94855649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.22415
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0741
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265614
GSE221327_6_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149264,GSE149267_2_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4994_METTL16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.680184
BRD-K79561347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07944
GSE159049_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
GE-29-ZM45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.600345
PMC11373733-ABR-13-34_Suppl1.pdf-283-ZNF138_ZNF138	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171486_4_v_6_ddx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K74091626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50068
GSE160246_0_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100344_HIP_probable Alzheimer's disease_TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02745
GSE139455_7_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ku70:Ku80 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.504
CRCGN015_MCF10A_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1106
BRD-K14087001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47495