association	dataset	threshold value	standardized value
Perturb_9194_KD_DDX3X_SRP299259	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
K562_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148943
Perturb_5551_KO_FBXO11_SRP149805	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-19.1549
GSE217873_1_v_0_nusap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE127790_11_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_EED226_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141292
Perturb_15507_KD_MYC_SRP279303	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.04578
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189982
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.612132
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.6245
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48692
MED4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00757
MCF7_Tucidinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147193
periventricular stratum of r6Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33517
GSE110178_5_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0011-R2a-SM-2I3GG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982606
GTEX-SE5C-0726-SM-4BRWY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92057
K562_ABT-737_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150879
K562_EED226_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157398
GSE62843,GSE64371_2_v_0_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_8278_KD_UTP3_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.74
ROS50	DepMap CRISPR Gene Dependency	1.0	5.08127
MCF7_AR-42_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143714
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.39682
ASAH1	Pathway Commons Protein-Protein Interactions	1.0	null
posteroventral (inferior) parietal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.35179
A-673	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19612
GSE89018_6_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175925
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A5A3-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15420_KD_RNF2_SRP116142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.03796
PMC11625982-AJH-100-10-s001.pdf-26-ZNF682_ZNF682	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198613
pc3	HPA Cell Line Gene Expression Profiles	1.0	1.48909
PMC9229595-Table_2.xlsx-LPS_subset_IX-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_2734_KD_BCKDK_SRP298085	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.14873
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE199644_3_v_2_palmitic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_12_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_WP1066_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237633
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.980528
GTEX-X4XX-0926-SM-46MV7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55748
GSE235066_4_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184464
GTEX-OOBJ-2626-SM-2I3F6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29131
GSE158834_1_v_6_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r7BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18316
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.967469
ARNT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5498
GSE149903_6_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179836
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27571
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MN-A4N1-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-MR-A8JO-01A-12R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202763
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8411
MCF7_S3I-201_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0203795
Perturb_3563_KD_HMGA1_SRP299065	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.74517
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R3-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.517123
amygdaloid complex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1695
posteroventral (inferior) parietal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.39535
RH30	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53987
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BI-78D3_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0205627
GSE120612_7_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
3479_GOSR2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00005
NB10	DepMap CRISPR Gene Dependency	1.0	3.54438
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_9829_KD_USP7_SRP256243	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.0001
Perturb_10664_OE_HSPB3_SRP288471	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.105
GSE124410_2_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.12274
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64262
FLNC	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A513-01A-12R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318055
dorsolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.59782
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38906
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8S9-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUIT-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A9WH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r6 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33517
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_TMP195_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0247303
GSE125782_3_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CC-61-KS26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237459
GTEX-UJMC-1326-SM-4IHLS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893953
GSE144838_4_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34429
GSE146982_7_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PLCD3	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9745835-supp_079195.122_Supplemental_Table_1.xlsx-ADAR-KD-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
COV318	CCLE Cell Line Gene CNV Profiles	-1.0	-2.23195
GSE178255_2_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Mocetinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232043
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE184892_6_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197322
Basomedial amygdalar nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15783
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7232_KO_ADIPOR2_SRP285935	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.19366
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_7_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10653
MCF7_Dacinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0094572
BT12	DepMap CRISPR Gene Dependency	1.0	2.92193
GTEX-WOFM-1326-SM-3MJFR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57207
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04306
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RU1J-0126-SM-2TF6Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874829
CAOV4	DepMap CRISPR Gene Dependency	1.0	3.4492
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53254
GSE183413_1_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2	ChEA Transcription Factor Targets	1.0	null
Perturb_7838_KO_AGO1_SRP136692	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.32244
STAT1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_13928_OE_DLG2_ERP119345	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.72725
A549_Danusertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182214
Perturb_15472_KD_KLF5_SRP256723	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.76736
GSE243683_0_v_1_s100a16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.893745
GSE143512,GSE143513_0_v_1_nr4a3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE248858_4_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200352_10_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QMR6-0011-R4A-SM-32PKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939668
PFKM	Pathway Commons Protein-Protein Interactions	1.0	null
HCC1419	COSMIC Cell Line Gene CNV Profiles	1.0	2.07776
GTEX-QVUS-0011-R4A-SM-3GAE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870496
Perturb_15419_KD_RNF2_SRP116142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.8765
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.412439
basomedial amygdaloid nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03515
Busulfan_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0135865
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.4426
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A182-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-96-8169-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
t64-ovaries_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.92272
periventricular stratum of r6Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45977
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
endometrium_8a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.973075
GLMN	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE131161_3_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163072
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.920827
J82	DepMap CRISPR Gene Dependency	1.0	3.85312
Perturb_96_KI_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.29966
GSE93674_1_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Divalproex Sodium_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127377
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3124
FNTB	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X15G-0526-SM-3NMB7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40457
MCF7_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236615
A549_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134175
EPAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17149
ERG-20517297-VCAP-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MCF7_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183835
aire_21746930_treg_cd8pos_cd28low_lof_mouse_gpl6246_gds4373	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.481017
ventral premammillary nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6513
OSBP	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_3667_KO_FASTKD_SRP277516	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Pneo-r__CIC-1n_h-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
DA-81-VY50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.367975
MC-40-IP75_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319484
MCF7_Tacedinaline_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0280967
GSE245270_1_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
MT-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.824534
MAPK8	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42252
MCF7_Lomustine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015383
GSE82110,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5181
superficial stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28234
mantle zone of AHy	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15417
GTEX-OIZH-2626-SM-2HMJM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61889
MCF7_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183918
GSE193993_1_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
IZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03405
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80724
CTCF_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987903
TC-71	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.41866
LJI308_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00544997
GTEX-S7PM-0011-R5A-SM-3NM8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25365
superficial stratum of r5BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53029
HS172T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49359
ZMPSTE24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21478
CYFIP1	Pathway Commons Protein-Protein Interactions	1.0	null
periventricular stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40445
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17613_KI_FOXP2_SRP225889	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_71_KD_LINE1_ERP011233	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.05972
WC-59-RG09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264547
EHD1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PWO3-0011-R2A-SM-2S1OX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11183
GSE180200,GSE180201_2_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
r5 part of ventral lateral lemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21266
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.8516
GSE178255_1_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
GSE110178_4_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22398
Perturb_3842_KD_NUAK1_ERP105460	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.52508
GSE149903_0_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-A5DR-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BFTC909	DepMap CRISPR Gene Dependency	1.0	3.60511
intermediate stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26943
PTER	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189667
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09426
Perturb_3638_KO_BRD2_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.93844
GSE147943_0_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_12704_KO_LIPA_SRP310406	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.35084
Perturb_9841_KD_KDM6A_SRP254623	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.3363
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPM-2626-SM-33HC5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29935
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.863943
Postpiriform transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24717
CTCF_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.51121
MOLM14	DepMap CRISPR Gene Dependency	1.0	2.12901
BF-79-GG96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213444
E2F4	ENCODE Transcription Factor Targets	1.0	null
BRE	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-REY6-0526-SM-2TF5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30152
Perturb_11407_KD_HNRNPM_SRP143499	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.87763
hsa-miR-4704-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.894536
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE181461_1_v_4_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012176
HCC38	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64966
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.873388
M059K	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41225
GSE94814_1_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BV-173	COSMIC Cell Line Gene CNV Profiles	1.0	2.07776
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
Lung adenocarcinoma_LUAD_TCGA-86-7713-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
PBX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15631
GTEX-NL3H-0011-R4a-SM-2I3GK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923073
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.93261
MCF7_Altretamine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0417067
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MP-A4SW-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LN-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33876
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V1D1-0926-SM-4JBHQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4716
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.4105
bronchus	HPA Tissue Protein Expression Profiles	1.0	1.20327
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.953886
Perturb_12998_KD_Myd88_SRP376414	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.53591
Perturb_11429_OE_WWTR1/FOSL1_SRP360169	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.7326
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24182
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.04486
NCIH358	CCLE Cell Line Gene Expression Profiles	1.0	1.41416
GSE168587,GSE168752_3_v_1_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XPVG-1826-SM-4B64X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911231
GTEX-Q2AG-0826-SM-2HMKF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18289
NCI-H2172	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE114284_4_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223701
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905776
GSE117730,GSE117732_0_v_2_apobec2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CAND1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18367
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Sodium Phenylbutyrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0264522
TBP	ENCODE Transcription Factor Targets	1.0	null
SW1417	CCLE Cell Line Gene Expression Profiles	1.0	1.46146
Perturb_7429_KO|KD_RBFOX2|HNRNPM_SRP068106	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.55802
Medial amygdalar nucleus, anterodorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18851
GTEX-QMRM-0726-SM-2I5G8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68502
Tuberomammillary nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19642
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.58279
CSE1L	Pathway Commons Protein-Protein Interactions	1.0	null
r8 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38732
GTEX-QDVN-2426-SM-2S1Q4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908611
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06036
Lateral element	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.532
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221258
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22993
ERGIC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35944
GSE158853_0_v_1_hmgcs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244714
Perturb_2919_KD_Obf1_SRP237554	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.06566
MCF7_Quisinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139962
Brain Lower Grade Glioma_LGG_TCGA-HT-8010-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_PHA-680632_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0280085
GSE240439_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
17660535-TableS4c	GeneSigDB Published Gene Signatures	1.0	null
Perturb_12074_OE_Carm1_SRP134253	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.96416
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3122
SERPINB6	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36937
shell of T-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11923
periventricular stratum of r7Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11795
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MC-CAR	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41333
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11064
ANXA7	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Plantar fascial fibromatosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.918
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.915613
MCF7_Tacedinaline_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147573
MCF7_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018247
CTCF_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WYVS-0326-SM-3NM9V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4328
Perturb_6730_KD_UPF1_SRP327782	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.50929
MCF7_Filgotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150105
MCF7_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0273671
GTEX-QLQ7-0726-SM-2I5G2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44299
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.928494
K562_Rucaparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170907
GSE151612_4_v_3_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131182
SREBF2	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-RWS6-2126-SM-2XCAV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51149
DMS273	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
GSE122711_1_v_0_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T2IS-2626-SM-32QPP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62299
Prostate adenocarcinoma_PRAD_TCGA-J4-A83M-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PDIA3	Pathway Commons Protein-Protein Interactions	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244462
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224928
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-Q2AH-0726-SM-2I3EA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65925
GTEX-WEY5-0526-SM-3GIKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11214
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06327
GSE158834_0_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RU72-0011-R2A-SM-2TF6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87858
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RL-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14253_KD_QKI_SRP272585	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.6852
GSE152055_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TKQ2-1326-SM-4DXT9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905423
K562_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0179714
HUWE1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_9879_KD_ARID3a_SRP199224	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.45132
Perturb_15418_OE_KDM4B_SRP194543	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.20047
GTEX-WH7G-0526-SM-3NMBI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70262
Perturb_7878_KD_CPSF3_SRP266190	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.3811
GSE110178_1_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.001747
mist1_22510200_pancreas_c57bl6_lof_mouse_gpl6246_gds4341	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.259497
GSE149903_0_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Panobinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00861425
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.11103
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6II-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MECOM	ChEA Transcription Factor Targets	1.0	null
Perturb_7762_KD_IER3_SRP348787	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.26219
MCF7_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167493
GSE145915_5_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LD-48-CY61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.594961
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26147
K562_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213691
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE92614_1_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.615589
MCF7_Tranylcypromine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127023
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Unnamed_1_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.186
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4EP-3226-SM-3P5YR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13079
GSE158834_10_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165148
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.994891
K562_INO-1001_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243149
dorsal peduncular cortex, periventricular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4124
GTEX-WHSB-0326-SM-3LK6K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862347
PMC11462941-CAS-115-2947-s001.pdf-75-ZNF654_ZNF654	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SN8G-0326-SM-32PLG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7015
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.32462
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266277
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	150.382
Lung squamous cell carcinoma_LUSC_TCGA-56-7822-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3157-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
PMC10769395-media-2.xlsx-S2D_EF_Repressed_genes-Ebegboni_et_al_Supplemental_Table_S2D_Increased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
stratum lacunosum-moleculare of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.951969
A549_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01739
Perturb_7155_KD_ARID1A_SRP366384	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
EOMES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06005
r6 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45726
EXOC4	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH1435	CCLE Cell Line Gene Expression Profiles	1.0	2.77147
ZNF213	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	92.3319
GTEX-U3ZM-1226-SM-3DB9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0041
GTEX-WVLH-2926-SM-3MJG5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942952
Perturb_6842_KD_RALY_SRP234429	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.12478
GSE184210_0_v_1_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-W5WG-1426-SM-4KKZP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37462
Perturb_2122_KD_XRN2_SRP276651	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.64401
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11722
K562_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190573
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03842
layer IIIu of area 35r	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.64473
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAGLN2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158138
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Baricitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0438313
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4737-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.0423
Sarcoma_SARC_TCGA-QQ-A5V2-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRF	ENCODE Transcription Factor Targets	1.0	null
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3112
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SERBP1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161068
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13771
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1648	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.29825
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE173873_10_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06809
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.890665
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23168
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.902023
laterostriatal stripe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25914
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238463
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.68239
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8851354-Table_5.xlsx-Ruxolitinib_reg_FD-bound-Supplementary_Table_5_Genes_regulated_by_ruxolitinib_that_are_FUS-DDIT3_targets_in_MLS_402-91_cells_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.01456
JHOS-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3CC-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE133516_5_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SHPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08408
estradiol_homo sapiens_gpl570_gse16683	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Immune system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-S4Z8-0426-SM-3K2AH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832188
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962986
BZW1	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z3-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1781	COSMIC Cell Line Gene CNV Profiles	1.0	2.07776
A549_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121688
LRRC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32714
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11502
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MERO48A	DepMap CRISPR Gene Dependency	1.0	8.5563
vagina	HPA Tissue Protein Expression Profiles	1.0	1.20327
Lung adenocarcinoma_LUAD_TCGA-MP-A4TF-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Perturb_14630_KD_MSI1_SRP067129	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.65667
Perturb_17614_OE_FOXP2_SRP225889	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
K562_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177968
A549_Rucaparib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014337
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.865613
H3K27me3_CH12.LX_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0426-SM-2XCF8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40103
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42418
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Celecoxib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201033
PMC11116544-41698_2024_606_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_4_Significantly_differentially_expressed_genes_between_TCGA-HNSC_patients_carrying_amplified_MYC_and_wild-type_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
PPIA	Pathway Commons Protein-Protein Interactions	1.0	null
GSE149903_0_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146982_7_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0129977
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10863
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
MCF7_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0268229
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09108
Perturb_7474_KD_Chtopl_SRP144331	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.59031
Basal part of cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.979
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.96173
FANCD2	Pathway Commons Protein-Protein Interactions	1.0	null
IX	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.30876
A549_Rucaparib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177702
GSE88819_5_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023178
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
MCF7_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152721
A549_Crizotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01831
PMC12909843-41467_2026_68388_MOESM4_ESM.xlsx-fig3g-up-regulated_gene_expression_in_OTX2-KO_8CLCs_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126463_5_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
DD-68-ZP95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235105
AA-86-YY62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.458836
periventricular stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21922
GSE213746_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UJMC-0726-SM-3GADX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06002
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5763
VI, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15155
basomedial amygdaloid nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06521
EZH2-23942234-MYOBLASTS AND MYOTUBES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUZC-1326-SM-4BRV2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898171
COASY	Pathway Commons Protein-Protein Interactions	1.0	null
layer 2 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94594
GTEX-T5JW-1226-SM-3GACY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73636
r6 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37043
NCIH1666	CCLE Cell Line Gene Expression Profiles	1.0	1.4029
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.608148
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T6-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
capan2	HPA Cell Line Gene Expression Profiles	1.0	1.05879
LS 180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
DDX27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76455
GTEX-WFG8-1826-SM-4LVM4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832257
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.4576
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5561-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2342	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE183251_4_v_6_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32017
tongueepidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.928813
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.87009
Perturb_4715_KO_Hnrnpu/Trp53_SRP331236	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
SK-MM-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CCK-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
OLA1	Pathway Commons Protein-Protein Interactions	1.0	null
SIHA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XBED-1526-SM-4AT5W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841431
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13771
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33538
Cortical amygdalar area, posterior part, lateral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54451
Cortical amygdalar area, anterior part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62802
ZR-75-30	COSMIC Cell Line Gene CNV Profiles	1.0	2.07776
MYL6	Pathway Commons Protein-Protein Interactions	1.0	null
PcPV part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40194
A549_SNS-314 Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015348
PBX3	ENCODE Transcription Factor Targets	1.0	null
blastocysts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.31311
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199255,GSE199356_4_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH1975	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49951
mantle zone of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1603
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH1436	CCLE Cell Line Gene Expression Profiles	1.0	1.45861
Perturb_2367_KO_CGAS_ERP131756	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.80371
MCF7_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188547
GSE86507,GSE86509_7_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.855949
GTEX-WRHK-1626-SM-3MJFH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79191
RADX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01461
Perturb_12372_KD_SKP2_SRP297799	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.28258
PRKCA	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ8I-1126-SM-4BOO2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.96089
GSE226285_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCRN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62266
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE62843,GSE64371_2_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102486,GSE102490_1_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_1154_KO_USP29_SRP329795	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.53375
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3651_KO_RIPK1_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.8622
DSTN	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-L4-A4E5-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_WHI-P154_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140917
ALX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17282
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.956954
thyroid_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.55551
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Unnamed_13_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ST13P4	Pathway Commons Protein-Protein Interactions	1.0	null
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.855949
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19O-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4508	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE180200,GSE180201_5_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_524_KD_RL6/BRF1_SRP382324	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.35096
GSE154464_1_v_2_cdk6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178255_3_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SNOS-0426-SM-32PMH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918756
MCF7_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200071
CDC40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26078
Prostate adenocarcinoma_PRAD_TCGA-KK-A59Y-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184210_0_v_3_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE71491_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HARA	CCLE Cell Line Gene CNV Profiles	1.0	1.60432
GSE164757,GSE164759_1_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
parvocellular part of the r9LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51975
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0089
Nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68701
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05811
Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MINPP1	Pathway Commons Protein-Protein Interactions	1.0	null
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.99751
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.937613
NCI-H2347	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24354
lateral intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0656
MCF7_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0221717
GSE165122_0_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE231891_5_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF574	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04775
SUPT16H	Pathway Commons Protein-Protein Interactions	1.0	null
esophagus	HPA Tissue Protein Expression Profiles	1.0	1.20327
PK-45H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.856792
MCF7_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173685
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.543629
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16372
CHD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33844
HO-1-U-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87943
GSE130690,GSE130692_1_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_7565_KD_NUDT21_SRP327319	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.9793
Thorax	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-WYBS-1926-SM-3NM8N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6713
GTEX-T8EM-0226-SM-3DB7C	GTEx Tissue Sample Gene Expression Profiles	1.0	3.88068
C11orf58	Pathway Commons Protein-Protein Interactions	1.0	null
GSE152441,GSE152442_7_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SC-15402 (MKI67)	NURSA Protein Complexes	1.0	null
GTEX-QDVJ-1926-SM-2S1PJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32013
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09947
CL14	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59933
GSE169334,GSE169336_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-POYW-0826-SM-2XCEM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5603
WFDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35645
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155673
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.07192
Kidney Chromophobe_KICH_TCGA-KO-8409-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.61815
GTEX-VUSG-0426-SM-3GIKD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26258
Lung adenocarcinoma_LUAD_TCGA-86-8669-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-IS-A3K6-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE126463_6_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214505_0_v_1_akr1b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4686761-ncomms10068-s3.xlsx-S2E-MSC_up_specific-Supplementary_Data_2E_-_expression_of_up-regulated_genes_2_fold_change_specifically_in_MSC_PTEN-_-_vs_MSC_PTEN_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110178_5_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CC-03-PW00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303171
MCF7_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162355
Transverse filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.78
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QV44-0826-SM-2S1RG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20425
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Pneo-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-133b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
MCF7_Resminostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0302719
methylphenidate_mus musculus_gpl11180_gse33619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SRP68	Pathway Commons Protein-Protein Interactions	1.0	null
NCKAP1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9284696__F2	PFOCR Pathway Figure Associations 2024	1.0	null
GATA2	ChEA Transcription Factor Targets	1.0	null
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19993
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE140651,GSE140653_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228181_4_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R3RS-0726-SM-3GIJR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16314
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.950904
Perturb_3621_KO_SMARCC1_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.65671
RAB7A	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E8-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55E-0011-R11A-SM-2TC6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0276
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GAPDH	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_9815_KD_UTX_SRP062773	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.2276
RAC1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRP-0326-SM-33HBJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36093
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845046
GSE190186,GSE190188_0_v_5_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cortical amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46652
U251MG	CCLE Cell Line Gene CNV Profiles	-1.0	-1.75027
MCF7_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0382305
Ovarian serous carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
VCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66247
medial trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31892
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EC-01A-21R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901802
GTEX-N7MS-0011-R4a-SM-2HMKW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853936
PMC12592558-41419_2025_8097_MOESM4_ESM.xlsx-downregulated_3_-_DATASET_1-RNA_Seq_analysis_upon_lncMB3_KD_in_D283_Med_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.05508
r6 part of nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.21387
Perturb_4394_KD_EHMT2_SRP290196	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
substantia nigra, pars reticulata, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.37155
GTEX-XUJ4-2026-SM-4BOOW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937099
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.930403
GSE199255,GSE199356_3_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mantle zone of r9BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05798
Perturb_16970_KD_AJUBA_SRP253076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.32222
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114690_2_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-GRHL2_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_8708_KD_Irf2_SRP193480	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.53492
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31359
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.848586
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.39324
PMC12019336-41467_2025_58868_MOESM5_ESM.xlsx-Open_peaks_IKAROS_WT-Unnamed_5_IKZF1	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.98907
WT1-25993318-PODOCYTE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_7597_KO_TENT3A/TENT3B_SRP400572	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
STMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1057
GSE248858_1_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133516_0_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PCMTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24769
MZ7-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE149903_4_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.855642
GTEX-U8T8-1426-SM-3DB9H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06487
GSE200352_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TSE9-0626-SM-3DB8B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64887
MCF7_Epothilone A_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0220588
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AZ-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
Perturb_10030_KD_EIF4G2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.6586
JEKO1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.03996
MCF7_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167079
NTERA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.53579
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52488
skin_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.6893
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_ENMD-2076_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139555
MCF7_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190701
K562_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149851
karpas707	HPA Cell Line Gene Expression Profiles	-1.0	-0.890962
Perturb_336_OE_PBX1_SRP389513	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
MCF7_Sodium Phenylbutyrate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.030124
GSE149903_5_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30943
GSE162276_5_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Tie2 kinase inhibitor_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137033
GSE100102_4_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205591
MCF7_Luminespib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234813
Perturb_2440_KO_USP27X_SRP072918	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.92704
IV	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.915651
Acute Myeloid Leukemia_LAML_TCGA-AB-2898-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EFHD2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC5740759-40246_2017_131_MOESM1_ESM.xlsx-Table_S6-Synteny-Syntenic_Analysis_for_29_HSF1-CanSig_8q_Genes_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
AP1B1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_1160_KD_CELSR2_SRP149837	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.76275
GTEX-WRHU-0926-SM-4E3IG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47112
GTEX-R55C-0626-SM-2TF4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59763
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.83244
Perturb_14684_KO_Prkaa1/Prkaa2_ERP006813	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.87941
GTEX-XMD1-0011-R2B-SM-4AT5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872386
A549_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141036
Perturb_9695_KO_GPNMB_SRP382180	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MCF7_PD98059_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237984
A549_Barasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129974
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.42338
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MS-2526-SM-2D7W3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29052
GTEX-NPJ8-0011-R1a-SM-33HCB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975413
ACTB	Pathway Commons Protein-Protein Interactions	1.0	null
4956_MED6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21518
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.708988
SK-N-DZ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02613
GSE228106_3_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0271338
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_AR-42_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00929748
ZBTB22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02895
Budesonide_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0256812
Perturb_7599_KO_CTNNB1_ERP109990	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.88612
p1B part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23006
Perturb_7298_KD_PCIF1_SRP162223	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MAP7	Pathway Commons Protein-Protein Interactions	1.0	null
GSE89018_1_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.7241
PAX5_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE165122_0_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0236017
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32272
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213371
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	185.726
MCF7_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124796
liver	GTEx Tissue Gene Expression Profiles	-1.0	-1.07104
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3958
MCF7_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113513
Perturb_3591_KO_DDX6_ERP024006	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_11926_KO_SKI_SRP125960	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.44843
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UH-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE137177_1_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_11534_KD_THOR_SRP121007	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.8108
MCF7_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212378
MCF7_Rigosertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0260905
r7 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12192
GSE95602_3_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111660_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NF-A5CP-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE125782_3_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
OXSR1	Pathway Commons Protein-Protein Interactions	1.0	null
GB-73-QS80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310065
GTEX-T6MN-0011-R9A-SM-32QOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83554
CTCF_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8585-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7737_KD_HRSP12_SRP155278	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.20341
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-1326-SM-2TF6T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982475
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10579
Perturb_15534_KD_YAP1/WWTR1_SRP365715	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.04345
GSE239844_11_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
COPZ1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_3637_KO_BLVRB_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.132
H1_BMP4_Derived_Mesendoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.824039
GSE222574_0_v_2_lmna_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.711323
SNU216	CCLE Cell Line Gene CNV Profiles	1.0	1.41318
Rectum adenocarcinoma_READ_TCGA-DY-A1DD-01A-21R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205231
GTEX-T6MO-0226-SM-32QOL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.072
GTEX-QMR6-0011-R1A-SM-32PKW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31382
Perturb_2387_Mut_ASXL2_SRP333775	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.47854
CCDC97	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15663
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SFXN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39434
Perturb_3668_KO_FASTKD_SRP277516	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
STARD10	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A7CF-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0282723
UNC45A	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SUCS-0226-SM-32PLQ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.61499
GSE137177_2_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QMR6-0011-R5A-SM-32PKT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04238
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.947684
NSA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04069
GSE89018_11_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_1_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.378972
Lung adenocarcinoma_LUAD_TCGA-93-A4JO-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HAND1_HAND1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Primary hematopoietic stem cells G-CSF-mobilized Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.01844
GTEX-RU72-0126-SM-2TF6Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18421
GTEX-PWOO-2326-SM-2S1PQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.991392
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ACTN1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4909989-ncomms11840-s2.xlsx-down-regulate-TEAD4-S_YAP_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180643
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144532
GTEX-OHPN-0011-R4A-SM-2I5FD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01369
TP53I3	Pathway Commons Protein-Protein Interactions	1.0	null
CASP3	Pathway Commons Protein-Protein Interactions	1.0	null
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42118
GFI1B	ChEA Transcription Factor Targets	1.0	null
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840878
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE247862,GSE247863_0_v_3_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X585-0011-R11B-SM-46MUZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17794
MCF7_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234473
MCF7_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0249217
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DIFI	DepMap CRISPR Gene Dependency	1.0	4.09613
Perturb_12738_KD_TCF7L1_SRP094619	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.42069
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25486
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PATZ1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	187.752
NRF1	JASPAR Predicted Transcription Factor Targets	1.0	null
H1_Derived_Neuronal_Progenitor_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.17746
Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
periventricular stratum of r7Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34444
Lung adenocarcinoma_LUAD_TCGA-44-5644-01A-21R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDA-MB-415	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_Baricitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0251347
Perturb_6724_KD_PAF1_SRP103746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.30025
PSMA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1513
PMC10243915-uxad037_suppl_supplementary_table_s1b-table_s3b.pdf-38-GPBP1_GPBP1	Rummagene Transcription Factor Associations 2026	1.0	null
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.18134
Prostate adenocarcinoma_PRAD_TCGA-HC-7747-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.913334
hsa-miR-4520b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GR-ST	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.8738
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33991
GTEX-WL46-2826-SM-3LK81	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08443
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.55328
MCF7_PF-573228_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152609
GTEX-XBED-1426-SM-4AT4G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.9257
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.965647
WASH complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.239
Cortical amygdalar area, posterior part, lateral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.52741
ventrolateral prefrontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.527
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HGC27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34158
Perturb_5599_KD_YY1_SRP259187	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.38937
Entorhinal area, lateral part, layer 2a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04149
ZIC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.6176
GTEX-PVOW-2626-SM-32PL8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90388
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204689
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.841905
mediodorsal nucleus of thalamus_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.963521
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19524
ARMC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46406
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.911729
Perturb_9830_KD_USP7_SRP256243	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.9825
Lung adenocarcinoma_LUAD_TCGA-86-A4D0-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168459
Perturb_9908_KD_GRSF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.92398
HES2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8831
MCF7	CCLE Cell Line Gene Expression Profiles	1.0	2.10506
MCF7_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0260083
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38309
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-T6MN-0626-SM-32PM9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43258
Perturb_7453_KD_ERI2_SRP110692	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.55591
hsa-miR-3126-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE109530,GSE109531_1_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_7154_OE_MOV10_SRP029367	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.8982
Perturb_98_KD_INTS8_SRP262320	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.23546
GSE89018_12_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Anchored component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.373
PAX5	ENCODE Transcription Factor Targets	1.0	null
GSE158834_10_v_6_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4459	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GTEX-P4QT-0526-SM-2I3EX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952524
MCF7_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184258
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.414462
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02519
SNU1196	CCLE Cell Line Gene Expression Profiles	1.0	1.35005
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A97Q-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KNS42	CCLE Cell Line Gene Expression Profiles	-1.0	-1.62693
Adrenocortical carcinoma_ACC_TCGA-OR-A5JT-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ6-0426-SM-2I5FG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832669
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04621
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64257
SMG1	Pathway Commons Protein-Protein Interactions	1.0	null
ntera2	HPA Cell Line Gene Expression Profiles	-1.0	-1.09698
POU3F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71035
Perturb_10034_KD_PUF60_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.28564
Perturb_9818_KD_GATA3_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.4133
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.352194
NCI-H460	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-S4Q7-1026-SM-4AD75	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82553
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.23059
PIP4K2C	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98749
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_IOX2_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205179
GSE184902_3_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NPJ8-2126-SM-3MJGK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84314
CHD2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17317_KO_Ddx5_SRP284247	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.73157
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.27925
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_11594_OE_MYOD1_SRP106379	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.86958
KPNB1	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A51X-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE161295_2_v_3_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3397
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.843011
r8 portion of the hypoglossal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15219
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.90576
GSE214212_2_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Piriform-amygdalar area, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43557
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.12904
GSE158834_2_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R55F-0011-R6A-SM-2TF4L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00637
Lung squamous cell carcinoma_LUSC_TCGA-63-7021-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325747
G28T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.827619
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03183
Ventromedial hypothalamic nucleus, ventrolateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3378
GSE130956_0_v_3_icaritin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_338_OE_PBX1_SRP389513	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153717
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.903999
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_3121_KO_Slc45a3_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.16672
GSE238116_1_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_7484_KO_ZBTB10_SRP154124	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.35691
Perturb_7378_KO_PHF3_ERP112687	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.61671
RUSC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78268
SNU668	CCLE Cell Line Gene CNV Profiles	1.0	1.35197
Perturb_13145_KD_Atrx_SRP194170	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.28883
Perturb_16316_KD_POU2AF1_SRP336261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
Supraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.9478
GSE100316_7_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00047
A549_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154291
MCF7_2-Methoxyestradiol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0321589
PPIB	Pathway Commons Protein-Protein Interactions	1.0	null
ARHGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203329_2_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56284
COPB2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-SIU7-1826-SM-2XCE2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858565
GTEX-WRHU-0826-SM-3MJFN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962098
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.32361
MCF7_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188308
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1649
KB-92-MK13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.902551
GTEX-XGQ4-0426-SM-4AT4I	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13128
golgi apparatus	LOCATE Predicted Protein Localization Annotations	1.0	null
496100333_FWM_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.07921
MCF7_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184271
primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.25156
SKNBE2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68277
GSE126463_5_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201251
GSE157777_2_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tail of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.99458
MYO1F	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XOTO-0011-R11B-SM-4B64O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943309
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.28473
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F0-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SJXC-0726-SM-2XCFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09516
GSE138938_1_v_3_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_5564_KO_KDM4C_SRP375293	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.2874
CDAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39501
POLR2AphosphoS5_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09936
CB-13-WC72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272446
PAICS	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_1909_KO_Phgdh_SRP303616	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8630-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNX2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WY7C-0226-SM-3NB37	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91555
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209403
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_7936_KO_VTRNA1_SRP252980	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.766
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.216
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.918
r7 part of rostral ventromedial reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33517
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
PMC9229595-Table_2.xlsx-LPS_subset_IX-Unnamed_15_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.06317
GTEX-RWS6-0626-SM-2XCAS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51302
Perturb_7205_KD_U2AF1a/U2AF1b_ERP006200	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.77487
Perturb_638_KD_GATA3_SRP372594	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.5252
Perturb_6512_KD_ALKBH5_SRP090686	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.33205
MCF7_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193321
MCF7_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175879
PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE183413_0_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE143847_2_v_3_inhba_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159672
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.869244
17023574-TableS2	GeneSigDB Published Gene Signatures	1.0	null
FUBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52191
MCF7_Enzastaurin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117533
Lung squamous cell carcinoma_LUSC_TCGA-56-A49D-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE131161_5_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
oocyte	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.03692
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4352-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04288
TPT1	Pathway Commons Protein-Protein Interactions	1.0	null
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.2117
MYO1E	Pathway Commons Protein-Protein Interactions	1.0	null
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.03385
Rectum adenocarcinoma_READ_TCGA-EI-6885-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XV7Q-0126-SM-4BRVK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891577
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_3589_KO_DDX6_ERP024006	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE202434,GSE202438_10_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
COG4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE130396_8_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Tolmetin_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0307138
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.28322
Perturb_7554_Mut_FUS_SRP302857	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.42777
Perturb_9918_KD_MAGOH_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.5593
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MEWO_SKIN	CCLE Cell Line Proteomics	1.0	2.49548
Perturb_14677_KO_Prmt1_SRP153406	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.8059
Esophageal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.817
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.880812
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84595
COV318	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.01
hsa-miR-4269	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Perturb_7801_KD_PAF1_SRP064356	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.69837
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144643
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.56519
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.888807
Perturb_13255_KD_Paf1_SRP083772	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.4849
GSE158834_10_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0336321
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAN	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158834_10_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
VIIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.917563
GTEX-WWYW-3026-SM-3NB36	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944043
GTEX-TML8-1326-SM-4DXTO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872637
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.45022
HES1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6445
CTCF_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13869
GTEX-XPVG-0626-SM-4B65B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90364
DYNC1H1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224701
GTEX-N7MT-1026-SM-3TW8T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920774
PMC11630641-mmc8.xlsx-Human_1000cell_NOT_identified-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
20077526-TableS4	GeneSigDB Published Gene Signatures	1.0	null
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86338
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8042-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXA2_FOXA2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRL-0526-SM-2I3EZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890148
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4912-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00723
GSE149903_6_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160626
HCC1937	COSMIC Cell Line Gene CNV Profiles	1.0	2.07776
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326181
supragenual nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19364
SERF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07855
Smad4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.816
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1392
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAB5IF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39755
GTEX-Q2AI-0526-SM-2I3EJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.964938
ovary_8a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.55814
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.988913
MYO6	Pathway Commons Protein-Protein Interactions	1.0	null
GSE245778_1_v_0_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_2-Methoxyestradiol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.031611
Cortical amygdalar area, posterior part, medial zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64251
U266B1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.36528
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.997767
LDHA	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Trametinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125597
APELA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25271
XPO5	Pathway Commons Protein-Protein Interactions	1.0	null
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
WC-09-GD62_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.347102
Perturb_1676_KO_Mkl1_SRP273992	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.33709
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.33086
GSE100316_5_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0300026
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847662
nasopharynx	HPA Tissue Protein Expression Profiles	1.0	1.20327
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I0-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0341527
GSE126127_2_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
r1 part of vestibulocerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13403
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_10108_KD_EIF4A3_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.50087
GSE207611,GSE207612_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16831
Perturb_7306_KD_IER3_SRP348787	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.8014
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
posterolateral cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6401
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
AP3S1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE184902_3_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.873482
GTEX-R55D-1826-SM-48FEF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06335
GSE110178_1_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARHGDIB	Pathway Commons Protein-Protein Interactions	1.0	null
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SPTBN1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7863452-12920_2021_883_MOESM2_ESM.xls-SRG_23_HCC_vs_17_NT-GENENAME_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_17381_Mut_Zc3h12a_SRP328189	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.56234
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161418
Perturb_12303_KO_EZH2_SRP062995	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.45139
Perturb_8705_KD_SIRT1_SRP267968	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.9281
MCF7_Azacitidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137908
GA-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.999187
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3465-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6701_KD_ALAL1_SRP148427	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.68862
Perturb_3653_KO_UCHL1_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.8694
GSE126777_3_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OVMIU	DepMap CRISPR Gene Dependency	1.0	2.70354
GSE219195_4_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JW-1726-SM-3GADN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908854
MCF7_CEP-33779_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.039173
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200124
NCIH1650	CCLE Cell Line Gene Expression Profiles	1.0	1.84589
MX1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_2059_KD_CHERP_SRP354316	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.4258
OVMANA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
K562_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0152567
Perturb_7410_KD_HNRNPU_SRP010280	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.14995
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_39_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_7341_KD_SFPQ_SRP281189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.47555
K562_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139655
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09508
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.93816
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_3527_KD_EIF4A3_SRP385300	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.16975
Perturb_7380_KO_SMG7_ERP122822	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-16.382
intermediate part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05798
GSE114992,GSE114993_1_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13079
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.91313
Perturb_439_KD_MEP50_SRP073189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.12745
Perturb_7288_KD_FTO_SRP070463	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.07827
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.57741
MCF7_Trametinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136959
GSE167886_2_v_0_chd7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PLAGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62729
GSE228162_2_v_5_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Differentially_expressed_genes_identified_in_bulk_RNA-seq_of_FOXO1-_-_vs_FOXO1_hMSCs_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
BT20	CCLE Cell Line Gene Expression Profiles	1.0	1.34964
CTNNB1	ChEA Transcription Factor Targets	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08847
GTEX-XUZC-1626-SM-4BRVP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06899
A549_PFI-1_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0105084
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87861
PC-62-AQ92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21335
lateral posterior nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19942
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GRPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05401
GSE240027,GSE240030_1_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147647
NCI-H2795	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19612
VAC14	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_10052_KD_RPS19_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.51792
NCI-H460	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MCF7_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112495
GTEX-N7MT-1226-SM-2D7W4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1468
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCDC28B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52762
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A48R-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OXRO-1226-SM-48TDL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34097
GTEX-UTHO-2926-SM-3P5Z9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05914
MCF7_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0342661
E2F4_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7856-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE228181_2_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FE-64-KC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.444016
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	260.955
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184210_0_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_321_OE_primiR450a_SRP189900	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.45192
MM.1S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.848021
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.969087
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.20671
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848308
PMC4060771-170289.f1.pdf-537-TEAD3_TEAD3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178255_1_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100315_TCx_no dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.08766
KM12	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A3U9-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE98964_1_v_4_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EB2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A549_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170825
GTEX-S4UY-0526-SM-3K2AN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900868
Lymphoid tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23525
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPN-0011-R1A-SM-2I5GB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15669
Lung adenocarcinoma_LUAD_TCGA-97-8172-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE161295_4_v_3_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_1322_KD_VIRF3_SRP201368	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.09945
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-190-ZNF707_ZNF707	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_7810_KD_RAM_SRP091113	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.40691
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_2_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE222758_0_v_4_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.69073
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.994884
RC-K8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.89366
Perturb_8993_OE_LIMA1_ERP128082	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.74631
Perturb_3644_KO_EIF2AK3_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_2598_KD_PRMT6_SRP131294	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.43166
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32998
MCF7_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119374
MCF7_S-Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205137
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YF-01A-12R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AI-0326-SM-2I3EK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43816
GSE233679_14_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.279659
VZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30062
Perturb_14778_KO_PGRA_SRP309208	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.38566
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02017
Perturb_7682_KD_HNRNPK_SRP111756	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.80416
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3585_OE_CBFBMYH11_SRP312248	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5446
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75426
LGALS4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08009
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-52-7810-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE211286_7_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GPN1	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-8265-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE189653,GSE203344_2_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11143964-jciinsight-9-161356-s009.pdf-46-ZNF646_ZNF646	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R53T-0526-SM-3GADL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35105
SNU-638	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-124	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.69692
Perturb_9696_KO_GPNMB_SRP382180	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.70506
Infigratinib_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00574125
GSE229698_1_v_2_traf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183816
GSE146982_7_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.46436
YY1	ChEA Transcription Factor Targets	1.0	null
GSE201401_2_v_0_fgfr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r3 part of parvicellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28005
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82531
SRP72	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.947585
GTEX-PLZ6-1526-SM-2S1OC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16437
navicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0251
GTEX-U8T8-2326-SM-3DB96	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9274
periventricular stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40194
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE240027,GSE240030_1_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DA-07-LL18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.332042
Musculoskeletal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.918
Perturb_4346_KO_Tln1_SRP378238	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.1513
DC-23-UM36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.317055
Perturb_7379_KD_SMG5_ERP122822	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.34896
intermediate part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21266
MCF7_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0239468
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.80032
nucleus subceruleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.942287
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KG-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.38007
SHP77_LUNG	CCLE Cell Line Proteomics	1.0	2.85205
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0493
MYOG	ENCODE Transcription Factor Targets	1.0	null
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.78223
GSE184479_1_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE62843,GSE64370_0_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Dexmedetomidine_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0274488
GTEX-PX3G-1626-SM-2S1PT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22813
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153614
Perturb_9924_KD_RBM22_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.18031
Perturb_9970_KD_WDR43_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.5965
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Baricitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229917
T3M3	DepMap CRISPR Gene Dependency	1.0	3.51594
GTEX-X8HC-0726-SM-46MWG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41208
GSE233679_6_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6482-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SEPT7	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_3604_KO_ARID1A_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.96277
GSE114992,GSE114993_7_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OXRK-1726-SM-3NB16	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861333
GSE215351,GSE215794_1_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159006
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.504328
zona incerta, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.948159
Perturb_11579_KO_QPC_SRP166848	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.56879
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178255_5_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211579
MCF7_Pelitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195327
ENO1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE145311_1_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CE-95-YX02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.849433
SFSWAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43299
A2780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.71597
Prostate adenocarcinoma_PRAD_TCGA-V1-A8WV-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_8384_KO_LSD1_DRP006351	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.94554
MCF7_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133946
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0269098
Lung adenocarcinoma_LUAD_TCGA-62-8395-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q8-01A-31R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TD-69-UA90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200282
periventricular stratum of r5Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07884
MCF7_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164618
Perturb_10015_KD_HNRNPC_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.07644
BL1804 (MTA1)	NURSA Protein Complexes	1.0	null
corticoid layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07673
SEC23A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE220520_5_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-94-A4VJ-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_UNC1999_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01923
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265622
MCF7_Trichostatin A_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0340991
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00841156
GTEX-XUZC-1426-SM-4BRV3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900665
NR3C1	ENCODE Transcription Factor Targets	1.0	null
GSE191015_0_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S341-1826-SM-3K2AB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54913
GTEX-WHSB-1626-SM-3LK6J	GTEx Tissue Sample Gene Expression Profiles	1.0	3.14612
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08973
ventral posterior inferior nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.81193
Perturb_4668_KO_Wdr5/Trp53_SRP324834	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.45641
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83739
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
K562_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179818
DTYMK	Pathway Commons Protein-Protein Interactions	1.0	null
Entospletinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.880215
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846954
MCF7_Ramelteon_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0261932
ECGI10	CCLE Cell Line Gene CNV Profiles	-1.0	-1.52156
PMC10679662-mmc2.xlsx-NC-D5-ZEB2-siRNA-Upregulated-Gene_Symbol_ZEB2	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF620	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04624
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.4902
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Quisinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.010856
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
mantle zone of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23592
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00047
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1975	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23999
GTEX-X4XY-0826-SM-4E3JM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60616
GSE233679_14_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CW-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Amyloplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.591
K562_Altretamine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147789
MCF7_Bisindolylmaleimide IX_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135308
Perturb_7369_KD_HNRNPC_ERP012939	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.56399
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_6764_KO|KD_SERPINE2_SRP103746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.71635
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-UJMC-0326-SM-3GAE2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75225
STAT3-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22993
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.541414
MK-3903_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0127092
GTEX-WFG7-0326-SM-3GILI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22411
Perturb_16319_KD_HNRNPR_SRP144940	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.37263
Lung squamous cell carcinoma_LUSC_TCGA-34-A5IX-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0857
RNF144A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03816
Lung adenocarcinoma_LUAD_TCGA-95-A4VN-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TE8	CCLE Cell Line Gene CNV Profiles	1.0	1.40917
RERF-LC-MS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.56236
MCF7_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013455
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-71-CB15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228967
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
Perturb_6334_KO_Fnip1_SRP260964	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
K562_Ki16425_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163011
MCF7_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164266
GSE189683_1_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NADSYN1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_M344_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.018741
SRP14	Pathway Commons Protein-Protein Interactions	1.0	null
nrf1_22586274_liver_lof_mouse_gpl4134_gse35124	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.0353
Perturb_14017_KD_PGBD1_SRP398441	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.35162
amygdaloid complex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.56135
GSE202359_1_v_0_rbpms_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE62843,GSE64371_4_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BZW2	Pathway Commons Protein-Protein Interactions	1.0	null
ERG	ChEA Transcription Factor Targets	1.0	null
mantle zone of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11654
NB7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44122
NB4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.97761
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	140.185
GSK3B_knockdown_158_GSE35351	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.65206
Autosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.956
GSE193351_1_v_2_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CAL120	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43273
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35928
Perturb_7181_OE_MAGEA11_SRP216417	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.98135
KLF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	167.447
Perturb_10165_KD_DOT1L_SRP292382	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.20446
r7 part of the nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.14488
Perturb_9893_KD_SSRP1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.75617
COG6	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
105KC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.855949
WM-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.791706
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3Z9-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-A456-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1428	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20831
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6AW-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9891_KD_HSPD1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.37821
A549_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154523
UACC-893	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.145
Perturb_2764_KD_FOXA1_SRP077334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-male_port-EGR1_1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
Pancreas	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.35975
Radial spoke head	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.599
COPG2	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SOX17_SOX17	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205163,GSE205164_9_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_7423_KD_DKC1_SRP045222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.59744
Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE217071_3_v_0_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Entorhinal area, medial part, ventral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.18624
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.71102
MCF7_KW-2449_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216321
FREM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98018
NRF1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-133a	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.679531
SRP54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15832
FIG4	Pathway Commons Protein-Protein Interactions	1.0	null
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235295
anterior cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59744
MCF7_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013956
K562_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165164
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.884669
MCF7_BMS-265246_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138355
MCF7_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151936
NCIH524	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70197
Perturb_8781_KO_DNMT3A/DNMT3B_SRP186642	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.43143
Silodosin_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0188465
GTEX-S7SF-0226-SM-3K2BI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16513
PMC11531655-MCO2-5-e754-s001.docx-0-IRF7_Regulon_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
r3 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14409
Perturb_12657_KD_Yap1/Wwtr1_SRP212072	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Lung adenocarcinoma_LUAD_TCGA-MP-A4TD-01A-32R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mitoxantrone (dihydrochloride)_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0343559
GTEX-NPJ7-0011-R11A-SM-2I3E8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02988
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-HEP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.815
16651409-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
ZNF397	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37292
Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6133-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64853
K562_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170425
GTEX-W5X1-0826-SM-3GILN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.964132
RERF-LC-SQ1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PRPS2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151387
Lung adenocarcinoma_LUAD_TCGA-50-5066-02A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tuberomammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21236
ARFGEF2	Pathway Commons Protein-Protein Interactions	1.0	null
t55-gastrocnemius_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.85607
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963936
Perturb_7355_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.56665
Brain Lower Grade Glioma_LGG_TCGA-WY-A859-01A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9026_KD_lncFAM_SRP377217	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.45218
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_13_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11166884-mmc4.xlsx-Table_S3-Table_S3_proinflammatory-EC2_comparison_between_WT_and_TG_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45O-01A-21R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC35E4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55297
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.56698
MCF7_Obatoclax Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211854
Agranular insular area, ventral part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02626
Perindopril (erbumine)_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0169397
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.05554
NCI-H630	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cisplatin_homo sapiens_gpl570_gse23553	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE149903_6_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE108495_1_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195859
GSE224763_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4842
KM-12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30457
SZ in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.90762
Dorsal peduncular area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10821
Brain Lower Grade Glioma_LGG_TCGA-DU-A76K-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COPS6	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DA-20-VR86_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.365971
MCF7_Veliparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0331891
MCF7_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227497
COPS4	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_5648_KO_PHF19_SRP142503	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.04586
Perturb_11525_KD_SNW1_SRP092641	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.27799
MCF7_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0108756
MCF7_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150136
Liver hepatocellular carcinoma_LIHC_TCGA-K7-AAU7-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175934
GTEX-X4XX-0011-R11A-SM-46MWQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02045
KCL-22	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_14042_KD_HDAC1_SRP327853	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.9088
MCF7_Epothilone A_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186529
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r8 part of inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2778
CTCF	ENCODE Transcription Factor Targets	1.0	null
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10247733-41408_2023_863_MOESM4_ESM.pdf-574-ZSCAN1_ZSCAN1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9362915-pone.0272017.s004.xlsx-Day5_-0_7_Top-BBX_BBX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120612_7_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
5881_NUMA1_ENST00000393695.3	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.4176
GSE167956_1_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76503
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38123
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.880812
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46424
Perturb_8486_OE_PLXNB2_SRP282509	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.04589
lateral tuberal nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.928564
GTEX-X261-0011-R6B-SM-4E3J8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39559
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846496
MCF7_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015967
LE-40-JW92_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255676
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_PHA-680632_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112356
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3056
A549_UNC1999_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190981
Perturb_13381_KO_CTIP2_SRP150394	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.42444
DB-78-NM13_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307476
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.441966
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32203
Lung adenocarcinoma_LUAD_TCGA-MP-A4T4-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
Perturb_9088_KD_SUPT16H_SRP106869	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.02294
BCL11A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26784
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6601
GTEX-RN64-0626-SM-2TC5V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35381
trachea	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.77602
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.98392
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-1.17414
GTEX-NFK9-0726-SM-2HMJW	GTEx Tissue Sample Gene Expression Profiles	1.0	2.70395
NCI-H2347	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Perturb_15142_KD_LINC00473_SRP257261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.50823
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
FGF22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71699
GTEX-RM2N-0926-SM-48FD1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04645
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.38344
CTCF_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.953503
Perturb_2718_KD_BRD_SRP115100	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.19625
pyramidal layer of taenia tecta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14179
LY-2584702 (tosylate salt)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0110618
MCF7_XAV-939_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0214629
NUGC2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37637
A549_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152624
MCF7_MC1568_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0298152
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.628725
K562_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0266595
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17904
GTEX-QDVJ-0926-SM-2I5FU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03718
GTEX-P78B-1826-SM-3P5YX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900707
Perturb_7343_KD_SFPQ_SRP281189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.62342
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
GTEX-R3RS-0526-SM-3GADG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899048
Perturb_14649_KD_Paf1_SRP297013	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.05863
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.69661
CBS	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH2004RT	DepMap CRISPR Gene Dependency	1.0	2.38343
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.807
RCC2	Pathway Commons Protein-Protein Interactions	1.0	null
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348235
posteromedial cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63891
TUBA1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-6.15339
GTEX-XMD1-0011-R11A-SM-4AT5J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14328
GSE225735_0_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89371
KLF14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	143.813
GATM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41148
Perturb_14114_KD_ATF7IP_SRP156289	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.50923
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_10112_KD_FXR1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.0792
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE89018_1_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OF-47-EQ74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.98448
MCF7_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0262415
Perturb_10045_KD_EIF3D_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.2088
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146982_0_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12844
EC-01-PH79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236932
GSE142684_4_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
P30-OHK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114284_4_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173615
GTEX-P4QT-2626-SM-2I3FM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73221
lateral hypothalamic area, tuberal part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33222
GTEX-RU1J-0226-SM-2TF5Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96924
MCF7_Momelotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0245928
MCF7_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0308519
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE110178_1_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.02208
GSE235066_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WWYW-0826-SM-3NB2X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40175
GTEX-U3ZN-2126-SM-4DXU1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944038
hsa-miR-3128	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Perturb_14374_KD_SRF_SRP150935	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.7818
496100324_FWM_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.54391
C1orf210	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39315
r9 part of nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60843
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.945106
17683608-TableS3	GeneSigDB Published Gene Signatures	1.0	null
AIMP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE256181_1_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
r9 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29358
CARMIL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05381
GTEX-QEL4-0726-SM-3GIJ5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65602
MCF7_Pracinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156622
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEC6	DepMap CRISPR Gene Dependency	1.0	2.26884
MCF7_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137338
SW756	COSMIC Cell Line Gene Mutation Profiles	1.0	null
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342051
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.84484
Cortical amygdalar area, posterior part, medial zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36731
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ELF1-20517297-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_6423_KD_LOC646329_SRP220725	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.17162
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14345
Blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE203308_7_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05904
A2058	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SUIT2	DepMap CRISPR Gene Dependency	1.0	2.53865
A549_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148183
Perturb_11111_KO_Tsc1/Cpt2_SRP303636	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
central gray of the pons, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.893908
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206137
UTP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2432
Perturb_10403_KI_LAMC2_ERP136718	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.74595
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCIXC	DepMap CRISPR Gene Dependency	1.0	3.41089
GSE158834_0_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
TLX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13971
Perturb_7291_KI_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.284
r2 part of vestibular nucleus Y	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20622
MSN	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Decitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0113765
GSE245270_1_v_0_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.1659
PMC11749115-loae020_suppl_Supplementary_Table_S2.xlsx-CHOP-high-gene_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_INO-1001_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225751
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ALYREF	Pathway Commons Protein-Protein Interactions	1.0	null
GSE223334_3_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XBED-0826-SM-47JYC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11602
MCF7_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0305789
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6685
GTEX-X5EB-0726-SM-46MVR	GTEx Tissue Sample Gene Expression Profiles	1.0	2.36435
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PRKDC	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-7020-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Ivosidenib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191299
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178340_1_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EIF4G2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02295
GSE131887_1_v_4_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70R-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE206516,GSE206518_3_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.823934
MCF7_Abexinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171213
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7238-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-A8I2-01A-12R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_2384_KO_ASXL1_SRP333775	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.22034
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-male_port-EGR1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178255_5_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_3624_KO_SMARCD2_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.38233
GSE200352_11_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
medial part of r7B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1603
K562_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152951
PMC7863452-12920_2021_883_MOESM4_ESM.xls-SRG_10_GE1-HCC_vs_17NT-GENENAME_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hypothalamic amygdala	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15356
Perturb_106_KD_E2F4/E2F5_SRP296854	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.562
GABPA	ENCODE Transcription Factor Targets	1.0	null
SR-786	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.89814
GSE108614,GSE108615_3_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KPNYN	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50626
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.474
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE178255_5_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Rumen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.037
GSE121198,GSE129779_3_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PRPF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28571
Cortical amygdalar area, posterior part, lateral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33468
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09176
GSE226544_1_v_0_hnrnpa2b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4761-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.0945
pedunculo(pontine) tegmental  nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.59894
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-3923-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3419980-leu201249x2.xls-RUNX1-ETO_siRE_ChIPSeq_peaks_ge-gene_name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.973069
MCF7_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215155
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.36908
SP1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NELFE	ENCODE Transcription Factor Targets	1.0	null
SLBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19065
GTEX-RWSA-0826-SM-2XCBF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2842
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A50I-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PWN1-1526-SM-48TDA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844181
MRK-NU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
UBXN1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE145915_3_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE141143_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06897
GSE206516,GSE206518_0_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NOB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.43214
Acute Myeloid Leukemia_LAML_TCGA-AB-2861-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-8635-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.927623
6847_PSMA7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05442
skeletal muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.56256
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PLA2G4A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.948567
GSE144231_4_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989009
Perturb_6298_KD_CGA_SRP355115	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.0809
K562_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0208928
IRF4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.094
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
CUL2	Pathway Commons Protein-Protein Interactions	1.0	null
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23999
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EY-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RUNX1-22343733-KASUMI1-HUMAN-PERIPHBLOOD-AML	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_1456_KO_Cebpb_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.66726
MCC13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE115542_2_v_0_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
M059K	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24961
GSE198165,GSE198166_0_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_PF-573228_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161705
Perturb_6763_KO|KD_SERPINE2_SRP103746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.1499
EXOC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70117
GSE233679_6_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QXCU-0326-SM-2TC63	GTEx Tissue Sample Gene Expression Profiles	1.0	2.20005
hsa-miR-222-3p	MiRTarBase microRNA Targets	1.0	null
GSE71674,GSE71676_0_v_2_cbfa2t2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Disulfiram_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0270122
MCF7_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0267598
GTEX-PSDG-1126-SM-2S1ON	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97748
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.87064
EP300	ENCODE Transcription Factor Targets	1.0	null
MCF7_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0212788
MCF7_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00823848
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.72838
GSE132694,GSE132717_0_v_2_meis1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KMRC2	CCLE Cell Line Gene Expression Profiles	-1.0	-2.33648
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17006
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DE-01A-22R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0250756
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.549455
KNS42	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69584
GSE89018_12_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54I-01A-21R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CFPAC1_PANCREAS	CCLE Cell Line Proteomics	1.0	2.33881
Perturb_9922_KD_PCBP2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.57122
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
KCNC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50333
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4Z8-0326-SM-3K2AU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21337
Perturb_7317_Mut_RNPS1_ERP130711	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.75284
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5478-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8569982-41065_2021_205_MOESM1_ESM.xlsx-mono_THP1_a2b_tpm1-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_2732_KD_TBX1_SRP264754	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.05404
MCF7_Pelitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140962
HCC1395	CCLE Cell Line Gene CNV Profiles	1.0	1.34928
RPS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1226
GSE180200,GSE180201_15_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IPO4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE89018_10_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_7397_KD_DHX38_ERP132987	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.42436
GSE179880_7_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
EW-16	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE205316,GSE205317_0_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.573876
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.405568
GNB2L1	Pathway Commons Protein-Protein Interactions	1.0	null
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.825478
MVB12A	Pathway Commons Protein-Protein Interactions	1.0	null
KMS18	DepMap CRISPR Gene Dependency	1.0	10.1499
GSE110178_2_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	166.411
GSE166315_1_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17X-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4911
RORC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05035
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
TFAP4::ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.0391
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47X-01A-31R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144219
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lateral hypothalamic area, anterior region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02293
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118794_2_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ANKS1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19055
ZNF775	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15388
GTEX-T6MO-0426-SM-32QOI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84531
Perturb_16494_KD_RBM39_SRP301121	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
MCF7_Panobinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00791715
SIN3A	ENCODE Transcription Factor Targets	1.0	null
Sarcoma_SARC_TCGA-X6-A7W8-01A-21R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial subdivision of central nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.40414
spleen	HPA Tissue Protein Expression Profiles	-1.0	-1.56256
stomach	HPA Tissue Gene Expression Profiles	1.0	1.02431
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.782718
FOXA2	ENCODE Transcription Factor Targets	1.0	null
ANXA2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.48925
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_9399_KD_MYCN_SRP104120	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.35888
GSE226770_1_v_6_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OOBJ-0826-SM-3NB2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1912
III	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.888021
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29V-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_AZD1480_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158459
CAMA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.859567
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180200,GSE180201_3_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RAB10	Pathway Commons Protein-Protein Interactions	1.0	null
GSE178255_3_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IQGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_3515_KD_EIF4A3_ERP130710	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.17006
TFAP2E	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	78.1777
MCF7_ENMD-2076 L-Tartaric acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144738
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02801
ovary	HPA Tissue Gene Expression Profiles	-1.0	-1.00872
MCF7_Maraviroc_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0309368
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3642
MCF7_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151728
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256185
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NDUFS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07182
Perturb_7544_OE_ALPG_SRP277076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
16877703-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.63208
Perturb_7464_KD_U2SURP_SRP126064	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cortical amygdalar area, posterior part, medial zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28621
Serum metabolite levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	5.00969
NCI-H460	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.46807
HIKESHI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04827
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.13672
K562_Selisistat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176235
MCF7_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0239602
MCF7_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0417799
GSE233679_6_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HNF1B_HNF1B	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_3650_KO_PI4KB_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	112.306
GTEX-W5X1-0426-SM-3GILB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10203
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
liver	HPA Tissue Gene Expression Profiles	-1.0	-1.46154
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10037
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
rnf2_20805357_megakaryocytic_l8057_lof_mouse_gpl1261_gse33659	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.324904
GSE146072_0_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
r7 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34444
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE179031_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE145323,GSE145324_1_v_4_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE209601_0_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JURLMK1	CCLE Cell Line Gene CNV Profiles	1.0	1.36372
GSE131798,GSE131804_5_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Iniparib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134835
IQGAP2	Pathway Commons Protein-Protein Interactions	1.0	null
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00081
HCC1195	CCLE Cell Line Gene Expression Profiles	1.0	1.83415
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13195
GSE225735_1_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nucleus of the lateral olfactory tract, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63364
ELF1	ChEA Transcription Factor Targets	1.0	null
GSE123825_2_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.88471
GSE186647,GSE217287_1_v_3_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9362915-pone.0272017.s003.xlsx-Day5_-0_7_Top-BBX_BBX	Rummagene Transcription Factor Associations 2026	1.0	null
mRNA_POU5F1_16518401	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
TIPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5135
Liver hepatocellular carcinoma_LIHC_TCGA-WQ-A9G7-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177493
GSE199606_3_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016269
TICRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26828
A549_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197548
EW8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55973
KATO III	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.867875
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.86553
GTEX-T5JC-0011-R11A-SM-32PMB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1072
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5466-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138289
Nuclear pore complex and nucleocytoplasmic transport	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
GTEX-NPJ8-2626-SM-2D7W2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10506
GSE155305_3_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RNOR-0926-SM-2TF56	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2197
GSE225684_0_v_2_tfap4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BCL11A	ENCODE Transcription Factor Targets	1.0	null
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.838421
PFKFB2	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2IR-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
18504433-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.025595
Piriform-amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31834
GSE79663_2_v_0_tcf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATP6V1H	Pathway Commons Protein-Protein Interactions	1.0	null
GSE246461,GSE246463_5_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_11_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_7865_KO_SDE2_SRP239880	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
mantle zone of VAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04699
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nucleus of the trapezoid body	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00347
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.9504
POLR2AphosphoS5_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12264
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13741
STRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02442
CUL3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Ki16425_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183964
TF-77-DW08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.441548
HDQP1	CCLE Cell Line Gene CNV Profiles	1.0	1.46721
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3527
GSE178255_1_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40194
TCF12_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE192860_0_v_1_trifluoperazine_human	RummaGEO Drug Perturbation Signatures	1.0	null
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219356
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Armadillo-type fold	InterPro Predicted Protein Domain Annotations	1.0	null
SKMM2	CCLE Cell Line Gene CNV Profiles	1.0	1.59358
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7438-01A-21R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7950_KO_BAZ1A_SRP100570	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.63596
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132581
Perturb_17211_KD_GRHL2A_SRP124640	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.20384
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295043
Taenia tecta, dorsal part, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21545
K562_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141407
GC-69-JF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23854
Perturb_17229_KO_Tsc1_SRP096336	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.1384
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
External side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.602
Radial spoke	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.215
496100402_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.07992
Adrenocortical carcinoma_ACC_TCGA-OR-A5L5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137978
Prostate adenocarcinoma_PRAD_TCGA-HC-7213-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128333_2_v_1_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
IPO5	Pathway Commons Protein-Protein Interactions	1.0	null
CAMA1	DepMap CRISPR Gene Dependency	1.0	4.21272
15260889-TableS2a	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XV7Q-0326-SM-4BRVM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21428
GSE224877_2_v_1_pctp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate stratum of the VAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06406
GSE123825_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
periventricular stratum of r3Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27564
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Capivasertib_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0154858
Perturb_8494_KD_U2AF1_SRP221683	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.55147
MCF7_Luminespib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0103691
PXDNL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02802
GSE249544,GSE249637_9_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.89279
Entorhinal area, medial part, ventral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28848
Perturb_17307_KD_Chrm5_SRP222274	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.55278
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6845_KO_ABCE1_SRP244437	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.45611
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.94242
GTEX-N7MT-0011-R2a-SM-2I3GI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.968678
Mastitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
PMC11801220-NIHMS2038999-supplement-15.xlsx-Exc-PBX3-gene_PBX3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152432_1_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DE-98-FC24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.356251
Perturb_7062_KO_Mbnl1_SRP014709	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.37905
PMC12019336-41467_2025_58868_MOESM5_ESM.xlsx-Open_peaks_IKAROS_WT-Unnamed_11_IKZF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05197
GSE151782_3_v_0_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4793-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE100316_0_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_3613_KO_DPF1_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.68485
OVCAR-8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE197948_2_v_0_atp7b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Body Height	DisGeNET Gene-Phenotype Associations	1.0	null
SP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.833215
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846496
Perturb_3642_KO_DNMT1_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.6021
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NUGC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Oviductal fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.605
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266669
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235294
ANAPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51987
NCI-H1650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.979167
GSE139911_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SW 48	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
A549_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115536
Lung adenocarcinoma_LUAD_TCGA-55-8507-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145221
MCF7_BMS-536924_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140956
POU5F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26995
primary auditory cortex (core)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25307
r10 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17051
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.45391
Brain Lower Grade Glioma_LGG_TCGA-HT-A74J-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151612_4_v_11_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1218
MCF7_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157296
ACSS2	Pathway Commons Protein-Protein Interactions	1.0	null
ARHGEF16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14906
VMRC-LCD	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QCQG-0326-SM-2I3ES	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987212
MCF7_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147534
anterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.17974
Perturb_14669_KO_Prkaa1/Prkaa2_ERP006813	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
MCF7_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138582
RAB5B	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_500_KD_RL6/BRF1_SRP382324	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.08277
GSE144838_7_v_8_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10679662-mmc3.xlsx-NC-D5-ZEB2-Mutant-Upregulated-Gene_Symbol_ZEB2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Ki16425_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0332735
KE-28-MO72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253288
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32017
KATOIII	CCLE Cell Line Gene Expression Profiles	1.0	2.14742
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZN-0326-SM-3DB86	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48544
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.51862
GSE100102_0_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83099
GSE158834_10_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
MCF7_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015599
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE110178_5_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cochlear nucleus, subpedunclular granular region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04464
PPIL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36765
ACSL4	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-634	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE179880_10_v_3_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SLX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67728
GTEX-V955-2426-SM-3GAEF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4208
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
inner SZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.954442
Spleen	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
MCF7_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177343
OCIAML3	DepMap CRISPR Gene Dependency	1.0	2.19012
SSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25649
CIP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30734
GTEX-XOTO-0011-R6B-SM-4B65X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873822
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HNF4A_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_3_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_7430_KO|KD_RBFOX2|HNRNPM/RBFOX1_SRP068106	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.68201
OPM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.81125
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ventral premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49649
VSNL1	Pathway Commons Protein-Protein Interactions	1.0	null
H3-5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25917
GSE184479_3_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.956805
PCBP1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_6_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217132_0_v_1_pfkfb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_12580_OE_STK32B_SRP261296	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.9169
A549_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160343
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M5-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_10008_KD_HNRNPU_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.63145
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3433-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15682
Lung squamous cell carcinoma_LUSC_TCGA-85-8481-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDT8-0011-R5A-SM-32PKN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976853
MCF7_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155267
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
CCDC22	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9812
GTEX-UTHO-3126-SM-3P5ZB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874201
LU99	CCLE Cell Line Gene CNV Profiles	1.0	1.61391
CTCF_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145525
GTEX-SNOS-0226-SM-32PLR	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08427
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TUHR4TKB	DepMap CRISPR Gene Dependency	1.0	2.09507
GSE234340_4_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Basal plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.017
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221792
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-A48Z-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ1-0126-SM-33HB3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49716
GSE149124,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
C1orf131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2593
ventropallial amygdalopiriform area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04699
GSE235066_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-A46S-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GPA33	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_7824_KD_EWSR1_SRP106906	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_16840_KO_Bcl11b_SRP340294	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	17.3716
COPG1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0280523
periventricular stratum of r2Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20622
GTEX-PWN1-2626-SM-2I3FH	GTEx Tissue Sample Gene Expression Profiles	1.0	2.52655
MAX	ENCODE Transcription Factor Targets	1.0	null
FUOV1	CCLE Cell Line Gene CNV Profiles	1.0	1.42916
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S341-2026-SM-2XCAA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836699
Perturb_17548_KD_HMGN5_SRP354633	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.3641
GSE225141,GSE225143_2_v_3_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.583127
Armadillo-like helical	InterPro Predicted Protein Domain Annotations	1.0	null
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.74751
GTEX-RTLS-0526-SM-2TF64	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837552
GSE158834_10_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE254517_1_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
periventricular stratum of p1B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14209
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06406
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE230329_0_v_3_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
mantle zone of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28621
GTEX-RU72-0011-R11A-SM-2TF6J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883862
KG1	CCLE Cell Line Gene CNV Profiles	1.0	1.84065
Hesperidin_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0206777
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Basolateral plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.086
GSE166944_1_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146459
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16505
A-673	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24872
head of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24205
Lung adenocarcinoma_LUAD_TCGA-55-8616-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBX2-35687133-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Intracellular protein transport and DNA repair	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
A549_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236222
GTEX-PLZ4-1226-SM-2I5FE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57668
ITSN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04008
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842473
Cortical amygdalar area, anterior part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36021
GSE223540_1_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Psmb	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.743
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6850_PSMB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01805
PMC5195898-NIHMS825571-supplement-3.xlsx-Sheet1-H1975_M1_vs_H1975_M1_CIC_reconstitution_Differential_gene_expression_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
W chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.756
K562_Filgotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186613
IALM_LUNG	CCLE Cell Line Proteomics	1.0	12.1103
GTEX-P78B-0526-SM-2I5F7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52184
K562_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182311
TALDO1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4638-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157672
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02213
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07594
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.988243
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
USF1	ENCODE Transcription Factor Targets	1.0	null
GSE131649_6_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100641_PCx_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16444
PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_TAZ-CAMTA1_vs_EV-Gene_CAMTA1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE111660_1_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.47101
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.943366
RPMI 2650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-EGR1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
KANK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.027
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20831
MCF7_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0223371
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8212
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14825
SMAD4	ChEA Transcription Factor Targets	1.0	null
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.70492
QDPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35329
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5083-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDAMB436	CCLE Cell Line Gene CNV Profiles	1.0	1.71918
GTEX-T5JC-2326-SM-32PMR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0456
Perturb_15098_KD_PDHA1_SRP385600	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.94592
NCI-H1734	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_9894_KD_STAU1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.0199
MCF7_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0104416
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BTK_mutant_1_GDS1346	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-0.121467
GSE210580_0_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CEP120	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99844
NCIH650	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45858
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Nilotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175387
HCT 116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.89366
COPG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65689
GTEX-SIU7-1126-SM-2XCDW	GTEx Tissue Sample Gene Expression Profiles	1.0	2.6722
IMR32	CCLE Cell Line Gene Expression Profiles	-1.0	-2.22927
GSE223334_1_v_0_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_16770_KO_Lrch1_SRP261798	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.42477
A549_Panobinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128592
GSE235682_3_v_0_rbl2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X4LF-0426-SM-3NMB5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96732
Perturb_7497_KO_G3BP1/G3BP2_SRP192777	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.40633
LTN1	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00919173
MCF7_Nintedanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0279538
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30457
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.933975
Perturb_555_KD_PHF2_SRP277893	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.4492
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826493
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41R-01A-21R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AZD-8055_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0223497
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.500009
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A553-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_13131_KO_Kat6a_SRP126967	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
G6PD	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE244072_10_v_3_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5740759-40246_2017_131_MOESM1_ESM.xlsx-Table_S7-HSF1-Neigbhors-HSF1_Neighbors_hg38_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13528
GSE216352,GSE216354_1_v_0_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
parasubicular cortex (parasubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3141
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H460	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.951699
YY1-22570637-MALME-3M-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
16651414-Supp2	GeneSigDB Published Gene Signatures	1.0	null
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NTPCR	Pathway Commons Protein-Protein Interactions	1.0	null
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_2520_KD_JUN_SRP357624	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.40952
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A4IJ-01A-31R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATRFLOX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.895257
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.361042
MCF7_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154128
DAK	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_7434_OE_HTT_SRP071197	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.32926
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Tanespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147639
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20005
Pinosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.069
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.951699
GTEX-XBED-0126-SM-47JY7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87792
Perturb_7247_KO_CTNNB1_ERP109990	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.63718
GSE167218_1_v_0_hoxd12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DD-74-PJ26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.423021
GTEX-WVLH-0626-SM-3MJG7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34431
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CL-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Connective tissue disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.918
K562_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184795
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.849778
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-XBP1_XBP1	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.94419
MCF7_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150554
GSE234340_12_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14408
GTEX-PWOO-1326-SM-48TCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82906
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE100316_0_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14237
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE161295_0_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
STAT3	ChEA Transcription Factor Targets	1.0	null
Brain - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	5.81062
Perturb_7367_KD_H2BC21_SRP308810	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.67507
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SF-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229387
LB647-SCLC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
YIPF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05976
RTL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02136
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.44689
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.11036
SERPINB1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_7851_KD_XAB2_SRP193107	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.2054
MCF7_Patupilone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172988
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.18517
GSE217071_1_v_2_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110178_5_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.53355
MCF7_Avagacestat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.027059
Perturb_6787_KD_KRAS_ERP122260	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.9171
POU4F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34286
XPOT	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LU-99A	COSMIC Cell Line Gene CNV Profiles	1.0	2.07776
GTEX-OIZI-0726-SM-2XCEI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25002
NCI-H740	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.70072
Perturb_7204_KD_U2AF1a_ERP006200	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.90758
GSE149124,GSE149128_2_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EEF1B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40522
PA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.900114
A549_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153698
intermediate part of r7B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0221
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.929012
PMC8812561-pnas.2110428119.sd11.xlsx-Sheet1-The_overlapping_genes_of_LCDR_KD_RNA-seq_hnRNP_K_KD_RNA-seq_hnRNP_K_RIP-seq_and_eCLIP-seq_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152432_3_v_2_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111660_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CDC123	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22534
Lung squamous cell carcinoma_LUSC_TCGA-94-7033-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STRN3	Pathway Commons Protein-Protein Interactions	1.0	null
SET	Pathway Commons Protein-Protein Interactions	1.0	null
CAPZA2	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_SRT3025 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0420051
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.39059
K562_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149285
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.2796
MCF7_Temsirolimus_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.021713
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
JUND_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0626-SM-3NMC1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829129
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45173
TE10	CCLE Cell Line Gene Expression Profiles	1.0	1.37279
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56291
A549_ENMD-2076 L-Tartaric acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128204
Perturb_10138_KO_PRPF40B_SRP197235	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.30532
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88388
GSE247862,GSE247863_2_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U4B1-0626-SM-3DB8L	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08068
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.229
MCF7_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161883
SC-25-HE80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240214
dorsal subdivision of VLC	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46006
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74906
715_AURKB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.16001
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE184892_4_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ABL127	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
GSE158834_0_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYH11	Pathway Commons Protein-Protein Interactions	1.0	null
GSE139239_3_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
639-V	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Entorhinal area, lateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06492
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.93378
MCF7_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0258173
GTEX-WOFL-0726-SM-3MJG4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2818
A549_Tofacitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129861
TCF12	ENCODE Transcription Factor Targets	1.0	null
GTEX-SUCS-0626-SM-32PM5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12077
Perturb_15099_KD_SREBF2_SRP385600	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.33895
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04069
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.32563
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QEG5-0826-SM-2I5GF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17767
TRIM28	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.852165
MCF7_JNJ-26854165_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0213964
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.5237
PLEK2	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_GSK-LSD1 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139651
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845046
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	170.826
BV173	CCLE Cell Line Gene CNV Profiles	1.0	1.88342
GTEX-WHPG-0226-SM-3NMB9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3593
primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.42579
Perturb_1796_KO_lncFAO_SRP192861	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.01321
CTCF_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147210_2_v_5_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_3364_KO_Adora2a_SRP306572	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.39412
SIG-M5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Perturb_13784_OE_IL10RB_SRP329434	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.61427
GSE184892_0_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNG1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51997
KMRC20	DepMap CRISPR Gene Dependency	1.0	3.44795
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.779652
GSE211151_2_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08646
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.23207
HEY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8381
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F2-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DVL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2426
Perturb_2395_KD_TRIM28_SRP308699	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_2576_KD_LINE1_ERP011233	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.16623
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.56256
YAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	6.3758
GTEX-WL46-3026-SM-3LK7Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00408
SNU-601	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17392
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HT-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11593_OE_MYOD1_SRP105281	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.2244
Lung adenocarcinoma_LUAD_TCGA-62-8397-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Trifluridine_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0227546
MCF7_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151421
GTEX-UTHO-0011-R2A-SM-3GIKC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15294
Perturb_10027_KD_APOBEC3C_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.48057
Perturb_2988_KO_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.37367
LC1SQSF	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76656
Perturb_2345_KO_CGAS_ERP131756	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.86642
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276911
GSE71468,GSE76476_0_v_1_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118794_5_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191485
GTEX-VUSG-2626-SM-4KKZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892908
EE-98-PF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259562
CTU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70857
GSE244072_10_v_8_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-circARID1A_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215418
Perturb_2761_KD_FOXA1_SRP077334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.8239
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ALG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0087
Eplerenone_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00563165
Perturb_7351_KD_SFPQ_SRP281189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.26637
Perturb_3516_KD_MAGOH/MAGOHB_ERP130710	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.89788
Prostate adenocarcinoma_PRAD_TCGA-KK-A59Z-01A-12R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVMANA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.904246
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XOTO-0011-R9A-SM-4GICI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07282
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KC-32-GO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272315
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13577
COPS3	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Alendronate sodium trihydrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192885
MCF7_Tucidinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0244995
Sarcoma_SARC_TCGA-DX-A8BZ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE121319_1_v_2_gprc5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0215849
EBC1	CCLE Cell Line Gene Expression Profiles	1.0	1.36006
KMS-21BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
MCF7_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204571
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_13866_KD_KDM6B_SRP258989	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.64311
Prostate adenocarcinoma_PRAD_TCGA-HC-8258-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243159
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_707_KD_SETDB1_SRP116955	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00089
Perturb_2373_KO_ASXL1_SRP305063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.21815
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE144443_10_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DOR 13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02097
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33434
stomach_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.53989
MCF7_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259223
MCF7_Vandetanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149146
LOVO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
NOMO-1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.288
SEPT2	Pathway Commons Protein-Protein Interactions	1.0	null
VARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07857
GSE208350_0_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_2294_KD_DDX5_SRP139509	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.3184
KURAMOCHI	COSMIC Cell Line Gene CNV Profiles	1.0	2.07776
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17832
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85266
PFKP	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1428	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.42799
GSE159678_4_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r10 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31892
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5324_OE_Hif1a_SRP386119	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.77059
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.37194
GTEX-XUW1-1026-SM-4BONY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80485
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.806384
821_BET1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12875
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MZ in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06638
Perturb_14319_KD_YAP_SRP251526	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.52038
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03829
STAT3	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE184892_4_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
smoothmuscle_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.23953
PRDX1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.41421
nes	HPA Cell Line Gene Expression Profiles	-1.0	-1.98397
Perturb_2719_KD_BRD_SRP115100	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.10034
Atrial appendage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.542
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.76595
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11211
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.855149
CC-30-TN36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.399135
H3K27me3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2279	CCLE Cell Line Gene CNV Profiles	1.0	2.14004
GSE100316_3_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161959
GSE233679_12_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25317
Perturb_6621_KO_NEUROD1_SRP388830	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.07496
Perturb_7304_OE_SF3B1_SRP286876	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.82415
SCN4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27595
MCF7_NVP-BSK805 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242996
CA9-22	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MCF7_WHI-P154_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151248
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
QB-42-MC63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32703
CHD2	ENCODE Transcription Factor Targets	1.0	null
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846496
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Duodenum Mucosa	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.94615
MCF7_Quisinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0115321
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE223908,GSE223909_4_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_7258_KO_ASXL1_SRP305063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.5217
GSE220520_5_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_7425_KD_RBFOX2_SRP045481	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.6392
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4441
PMC10061014-Table5.XLSX-C_vs_LD-Table_S5c_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_DEX_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CAPZA1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_2721_KD_YAP1/WWTR1_SRP115100	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.6621
MCF7_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228097
MCF7_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176563
r9 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2559
Rennet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.951
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43229
PMC12103066-FEBS-292-2688-s001.pdf-50-ENSG00000101412_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02745
MCF7_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160996
CAPZB	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_11389_KD_BRG1_SRP261084	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.18017
GTEX-S4Z8-1826-SM-3K2BH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20477
Kidney Chromophobe_KICH_TCGA-KN-8426-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7625_KD_ICE1_SRP120604	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
plagl2_17983586_small_intestine_lof_mouse_gpl1261_gds3010	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.449702
MCF7_Fedratinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146484
SP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	190.27
MCF7_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148527
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52576
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A6UG-01A-32R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE190322,GSE190324_3_v_4_rbm4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XXEK-0126-SM-4BRVU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02739
GSE183606_1_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08187
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38552
Lung adenocarcinoma_LUAD_TCGA-55-A494-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-OE-A75W-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Msgn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.0701
SNAI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3354
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
LCLC-103H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01812
LS 174T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE140607_5_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
STARD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11912
GSE200839,GSE233826_5_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5430-01A-02R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184902_4_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KBM-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.025
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.850092
GK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31983
GSE228181_3_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_7209_KD_U2AF1a_ERP006200	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.01172
GSE116810_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
ACAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50947
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.960449
NR3C1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_13656_KO_TERT_SRP291201	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.85513
Procainamide (hydrochloride)_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.035599
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.17371
A549_Resveratrol_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189784
Temuterkib_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.020845
MCF7_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0288487
CAPG	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HK-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06445
mcf7	HPA Cell Line Gene Expression Profiles	1.0	1.42876
K562_Roscovitine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015624
Brain Lower Grade Glioma_LGG_TCGA-HT-8018-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_91_KO_SNORD77_ERP116971	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.76014
GSE118617,GSE118619_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216978
ribavirin_homo sapiens_gpl570_gds4391	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.393005
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.0752
OCIMY5	DepMap CRISPR Gene Dependency	1.0	4.38676
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100628_FWM_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01364
MCF7_MK-5108_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.021423
K562_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138559
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50427
Perturb_17233_KD_KLF2_SRP389914	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.83007
Perturb_735_KD_PAF1_SRP048744	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.9605
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89505
6540_POLR2A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.19671
lateral tuberal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.14386
intermediate stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08428
Perturb_10836_KO_Per1/Per2_SRP194523	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.39941
Perturb_16969_KD_AJUBA_SRP253076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.03261
GTEX-XAJ8-0526-SM-47JYK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881142
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905639
CW9019	DepMap CRISPR Gene Dependency	1.0	3.98613
Perturb_1094_KO_ATXN1L_SRP230198	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.41926
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WFG7-1526-SM-4LVMG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829684
GSE89018_1_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8043-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A902-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.895963
RUNX1-22343733-PBMC-HUMAN-BONEMARROW	ChEA Transcription Factor Targets 2022	1.0	null
RRN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88206
DE-20-VX20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204933
19218430-TableS3	GeneSigDB Published Gene Signatures	1.0	null
GSE145476_2_v_0_hopx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.891065
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.80765
LCLC103H	CCLE Cell Line Gene Expression Profiles	1.0	1.52945
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6144
Thymus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.89148
GTEX-RUSQ-1026-SM-2TF6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61534
NHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	89.2958
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Citrullinemia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.953
MCF7_Tanespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00957111
MCF7_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0247204
NCI-H1944	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71R-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7325-01B-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OBSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21573
PSN1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A616-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202284,GSE202289_7_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1419	CCLE Cell Line Gene CNV Profiles	1.0	2.44396
FUBP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE157555,GSE157556_4_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0270534
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.45601
SC-72-YW56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.463828
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.83244
GTEX-OHPK-2626-SM-2HMK9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44278
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05718
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.29932
GTEX-P4PP-1526-SM-3P61M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0803
PMC8017594-LSA-2019-00332_Table_S1_Table_12.xls-DCX-KD_LIS1-KD_DEGs-LIS1-KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203267_0_v_1_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HI-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161926
Perturb_11547_KD_PRKAA1/PRKAA2_SRP303942	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.53139
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08596
COX4I1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21452
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23558
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.56682
HCC1187	COSMIC Cell Line Gene CNV Profiles	1.0	2.07776
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-RA-A741-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Trunk	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00389
GSE138815,GSE138817_0_v_2_kdm6a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-POYW-0526-SM-2XCEY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08233
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.450503
ARF1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
medial amygdala, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.9152
GTEX-T6MN-2526-SM-32PMN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997679
Lung adenocarcinoma_LUAD_TCGA-62-A46P-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RU72-0011-R7A-SM-2TF5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.27011
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54318
MCF7_Rigosertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188318
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4698-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FLNB	Pathway Commons Protein-Protein Interactions	1.0	null
SNG-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.919243
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X261-0011-R11A-SM-4E3JY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835103
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.82474
Perturb_8766_KD_H19_SRP073245	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.62869
Perturb_17079_KO_Nhedc2_ERP105671	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.45491
MCF7_MK-5108_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0287238
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.977893
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NTERA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08596
SPIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22913
Perturb_14632_KD_MSI2_SRP067129	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.68504
MCF7_Cerdulatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0265076
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05919
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
NCIH2081	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6189
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC6584338-jcav10p2520s2.xlsx-total_validated_1577_genes-STAT5A_STAT5A	Rummagene Transcription Factor Associations 2026	1.0	null
Pt-K2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.448
Perturb_7374_KO_MGA_ERP067388	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.17469
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BAG6	Pathway Commons Protein-Protein Interactions	1.0	null
Waist circumference adjusted for body mass index	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.852288
COPS7A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE113221,GSE113968_6_v_1_prdm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139181
A549_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162339
GTEX-OXRL-1626-SM-2YUMU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4135
SNU349	CCLE Cell Line Gene Expression Profiles	-1.0	-1.87796
SGTA	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94334
Perturb_15873_KO_SMARCB1_SRP293781	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.00363
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06927
K562_ZM 447439_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144333
a-REST (TW) (REST)	NURSA Protein Complexes	1.0	null
VIIAf	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05258
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE166315_2_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PWCY-2326-SM-2I3EQ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.27407
GSE162688_3_v_4_pink1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
spleen	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.10384
Mitoxantrone (dihydrochloride)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0191482
K562_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160488
GTEX-XUJ4-0726-SM-4BOOP	GTEx Tissue Sample Gene Expression Profiles	1.0	2.12676
FOXP2_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-61-BE07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.407829
A549_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177668
CTCF_MEL cell line_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2029
GTEX-R55G-2326-SM-2TC61	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889037
GSE138818_1_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FANCI	Pathway Commons Protein-Protein Interactions	1.0	null
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Givinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00986786
GSE146982_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WH7G-1626-SM-4LVMY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997869
GTEX-UPIC-0226-SM-3GADO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48624
GSE216540_1_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XOTO-2926-SM-4B65G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916457
GTEX-R53T-1326-SM-48FCQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93557
MCF7_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0249694
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.995765
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00067
BE-13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
r5 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1381
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37106
MCF7_ENMD-2076_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014867
GSE198165,GSE198166_9_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE161295_0_v_5_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WYJK-1626-SM-3NM9J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83023
GTEX-XXEK-1326-SM-4BRV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22434
MYL6B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10359
RSU1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0209602
RCC-JW	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE201042_2_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07372
Perturb_10043_KD_EEF2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.2171
Perturb_9109_KD_STAT3_SRP363695	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.1966
primary auditory cortex (core)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15573
Perturb_3513_KD_RNPS1_ERP107441	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.07817
SW 480	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.880812
Cortical amygdalar area, posterior part, lateral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79108
SKRC31	CCLE Cell Line Gene Expression Profiles	-1.0	-1.65352
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.76763
Perturb_4393_KD_EHMT2_SRP290196	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE85565_1_v_0_tcf21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_M344_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020153
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.28088
SNU1033	CCLE Cell Line Gene Expression Profiles	1.0	1.71827
GTEX-Q734-0526-SM-2I3EH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25003
body of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.866892
KYSE70_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	2.02737
Lung adenocarcinoma_LUAD_TCGA-55-A493-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846496
K562_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162842
HUES64_Cell_Line	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.834207
deep layers of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.985554
SP1	JASPAR Predicted Transcription Factor Targets	1.0	null
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.6861
Perturb_9397_KD_MYCN_SRP104120	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.98224
VIIB	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28729
GTEX-OXRO-0011-R9A-SM-3NB1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20784
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.888044
GTEX-S32W-0726-SM-2XCBL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26755
Perturb_6737_KD_PAF1_SRP103746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.8241
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WL-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0428372
Piriform-amygdalar area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69648
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3602_KO_ACTB_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.37215
Pancreatic adenocarcinoma_PAAD_TCGA-F2-6880-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDVJ-0226-SM-2I5FV	GTEx Tissue Sample Gene Expression Profiles	1.0	2.26574
GSE149901_2_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OVCA420	DepMap CRISPR Gene Dependency	1.0	2.50001
GTEX-V1D1-2426-SM-3GAER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21953
Perturb_7331_KD_PCIF1_SRP162223	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-18.4202
MCF7_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBE2O	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-VUSG-1726-SM-4KKZL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04896
Perturb_7558_Mut_ASXL1_SRP305063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.36452
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2134
GSE165636_0_v_4_tofacitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE110268_2_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.71742
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37805
MYH9	Pathway Commons Protein-Protein Interactions	1.0	null
GSE228413_2_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Hesperadin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206771
KP-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5O9-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263782
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47765
NCI-H1944	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PKM	Pathway Commons Protein-Protein Interactions	1.0	null
GSE203308_9_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-98-8021-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Dacinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00895836
A549_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172584
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_6_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.78338
amygdaloid complex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0267
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_12_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_15635_KO_MAT2A_SRP351305	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
DB	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48181
Perturb_7327_KO_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.2907
dorsal peduncular cortex, intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26943
CLTC	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8628-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE162276_5_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_36_KD_RBPJ_SRP151852	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.77084
Perturb_95_KI_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.284
superficial stratum of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1669
NCI-H2110	COSMIC Cell Line Gene CNV Profiles	1.0	2.07776
MCF7_BMS-265246_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.012211
Perturb_17550_KD_HMG20A_SRP354496	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.57149
Perturb_2546_KD_EZH2_SRP067706	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.93901
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8684
Perturb_7409_KD_HNRNPU_SRP010280	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.38082
HUG1N	CCLE Cell Line Gene Expression Profiles	1.0	1.48884
cerebellum	HPA Tissue Protein Expression Profiles	-1.0	-1.56256
MCF7_Tacedinaline_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0214135
Sarcoma_SARC_TCGA-DX-A3UD-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRF_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6X2-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A654-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.3657
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
posterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1091
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r7 part of nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.08242
EC-01-PH79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227229
MCF7_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141085
E2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	81.2423
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13771
Perturb_8704_KD_SIRT1_SRP267968	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.43038
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_7699_KD_SKIIP_SRP155347	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.11848
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-0011-R9A-SM-3GIJA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29281
GTEX-NPJ8-0011-R11A-SM-2YUMS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02959
GTEX-XMD1-2826-SM-4AT5F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12335
Perturb_13867_KD_KDM6B_SRP258989	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.71104
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16967
ISG20L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17578
Perturb_11691_OE_MYC_SRP253943	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Medial amygdalar nucleus, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08138
K562_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0258154
Perturb_7292_KI_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.29966
SLFN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02677
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47739
MCF7_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141941
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.7143
GTEX-NL4W-0011-R9a-SM-2I3G1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07904
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.945655
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-XOTO-0011-R5A-SM-4B657	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862553
IA-76-ZU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.418081
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.52387
Perturb_11403_KD_CPT1A_SRP076884	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.88249
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.35069
HEC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04939
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.89757
Perturb_1429_KO_Prkcd_SRP386893	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.95795
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
UBE2Q1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34414
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18516
HGC27	CCLE Cell Line Gene Expression Profiles	-1.0	-2.16218
MYL12B	Pathway Commons Protein-Protein Interactions	1.0	null
ETC-206_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0264797
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.81565
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QS-2626-SM-2I3EV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29124
MCC13	DepMap CRISPR Gene Dependency	1.0	2.69506
Cortical amygdalar area, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4442
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.58703
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08256
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
KMS11	DepMap CRISPR Gene Dependency	1.0	2.13551
V, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.952456
CLTA	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-JV-A75J-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DNM2	Pathway Commons Protein-Protein Interactions	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.89388
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.3476
GSE101336_1_v_0_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.9461
MCF7_BRD4770_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168199
PLXNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42406
GTEX-VJWN-0426-SM-3GIJI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41329
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
plexiform layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45257
CP21R7_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0123325
GSE108675_2_v_1_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317544
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30934
Lung squamous cell carcinoma_LUSC_TCGA-43-5670-01A-21R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH2347	CCLE Cell Line Gene Expression Profiles	1.0	1.4861
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1QB-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16842
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE168596_1_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_UNC1999_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00958712
GSE196671_6_v_8_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-VJYA-0426-SM-3GIJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2311
Lung squamous cell carcinoma_LUSC_TCGA-18-3408-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.48309
XPO7	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-335-5p	MiRTarBase microRNA Targets	1.0	null
ZR7530	CCLE Cell Line Gene CNV Profiles	1.0	2.00165
PCDHB14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04088
GSE109565_12_v_11_glyphosate_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Mocetinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134017
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985495
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6855_PSMB6_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0738
SP2	ENCODE Transcription Factor Targets	1.0	null
striatum_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.894473
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.918
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.27065
GSE205163,GSE205164_3_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Esophageal squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.784
Perturb_3913_KD_Y14_SRP118481	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.1125
digits	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.64701
K562_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166444
Bestatin (hydrochloride)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00422451
MCF7_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187242
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
Perturb_12492_KD_PELP1_SRP351131	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.32958
GTEX-QLQW-0226-SM-447BJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874064
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8301-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
RMC-6236_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.030882
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWN1-1426-SM-48TDF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890662
GSE180200,GSE180201_3_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.3253
GTEX-WFON-0626-SM-4LVLX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845132
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2887	DepMap CRISPR Gene Dependency	1.0	3.20029
ZW10	Pathway Commons Protein-Protein Interactions	1.0	null
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.39642
23132-87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48579
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF610	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	96.2397
A549_ABT-737_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140283
Perturb_520_KD_RNF113A_SRP201913	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.73796
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.8439
GSE239844_11_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-98-A53B-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06292
A549_Barasertib_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143257
Perturb_1689_KO_Rptor_SRP101878	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.61612
post-lysosomal vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.774
Perturb_9112_KD_STAT3_SRP363695	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.7829
CEBPB_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946713
PMC3721393-bjc2013326x2.xls-Neuroblastoma_SOX10_Gene_Sign-Gene_name_SOX10	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11692_KD|OE_SF3A3|MYC_SRP253943	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BL41	CCLE Cell Line Gene CNV Profiles	1.0	1.37428
Entorhinal area, medial part, ventral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51858
4931_MED11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01612
GSE148252_1_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.935124
MCF7_Patupilone_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160722
15735024-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
Perturb_3940_KD_IRGM_ERP122050	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.87114
hESC_Derived_CD56+_Ectoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.91023
GSE235066_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-432	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7387
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0322969
20077526-TableS3	GeneSigDB Published Gene Signatures	1.0	null
Perturb_7210_KD_U2AF1b_ERP006200	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.66874
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.490842
PF-59-CY33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.398642
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M3-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154563
ONECUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14605
inner SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.840935
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3Y4-01A-51R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE200839,GSE233826_3_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_1_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Perturb_2393_KD_HIF1A/HIF2A_SRP308699	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.2747
substantia nigra, pars reticulata, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02044
Perturb_14765_KD_HDAC5_SRP265842	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-19.2218
MCF7_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219878
Perturb_3636_KO_BAZ2A_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.7432
GTEX-UTHO-0726-SM-3GAEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.958378
HCC89	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.918772
GSE247764_3_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S7SE-0726-SM-2XCD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14667
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
CA SKI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.939276
episupraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.20162
GSE62843,GSE64370_0_v_1_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S4Q7-0326-SM-3K2B1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59839
Perturb_4378_KD_MALT1_SRP127318	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.50438
Growth hormone receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.597
MCF7_SRT1720 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131033
GSE102870_3_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_15549_KD_Klf4_SRP148691	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.3118
Perturb_7282_KD_RNPS1_ERP130711	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.89513
GSE154074_2_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14689
MCF7_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.021577
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09636
MCF7_Epothilone A_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151833
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06965
GTEX-SIU8-0626-SM-2XCDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08057
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A66Y-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1781	CCLE Cell Line Gene CNV Profiles	1.0	2.10434
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44185
MCF7_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138963
PMC7616986-EMS181817-supplement-Supplemenatry_tables.pdf-47-NFIL3_NFIL3	Rummagene Transcription Factor Associations 2026	1.0	null
EJM	CCLE Cell Line Gene Expression Profiles	1.0	1.51204
Adrenocortical carcinoma_ACC_TCGA-OR-A5JV-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NPM1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_AT9283_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114141
SHI1	DepMap CRISPR Gene Dependency	1.0	9.92335
GTEX-X638-0326-SM-47JY1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926772
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	1.0	null
lhx8_18509161_newborn_ovary_lof_mouse_gpl1261_gds3254	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.43003
MCF7_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00777881
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.75218
HCC1937	CCLE Cell Line Gene Expression Profiles	1.0	2.49155
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845046
Perturb_15458_KD_TIP5_SRP198493	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.30277
MCF7_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232911
MCF7_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0330929
D283MED	CCLE Cell Line Gene Expression Profiles	-1.0	-2.70628
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TLN1	Pathway Commons Protein-Protein Interactions	1.0	null
A549_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189695
inferolateral temporal cortex (area TEv, area 20)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.998556
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161908
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28577
thyroid_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.55104
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6766_KD_PAF1_SRP103746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.3898
MCF7_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0239617
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rh30	HPA Cell Line Gene Expression Profiles	-1.0	-1.25464
Acute Myeloid Leukemia_LAML_TCGA-AB-2920-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE144500_8_v_2_ventx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Alisertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148128
KASUMI2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	5.27893
Perturb_12176_Mut|KO_PLK4_ERP132994	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.9648
r7 portion of the hypoglossal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00161
Resveratrol_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0132397
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25273
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.01712
GSE144838_7_v_5_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYO1C	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15248
PMC12103066-FEBS-292-2688-s001.pdf-50-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
DCTN2	Pathway Commons Protein-Protein Interactions	1.0	null
HCCS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14289
Perturb_6028_KD_KHDRBS1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.8281
TNPO1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Capecitabine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.023217
BC-33-BM51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238737
GTEX-NPJ8-0326-SM-2D7VV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904575
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
PCNA	Pathway Commons Protein-Protein Interactions	1.0	null
GSE178255_5_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20522
PMC3889689-elife01439s001.xls-RFX2_rnaseq_chip_DirectDE_final-GeneName_RFX2	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-339-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
ventrolateral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56967
A549_TMP195_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169834
HMGB1	Pathway Commons Protein-Protein Interactions	1.0	null
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284925
intermediate stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02022
mantle zone of r10BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21054
PMC10061014-Table5.XLSX-C_vs_L-Table_S5a_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
23132/87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.895257
Nucleus of the lateral olfactory tract, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28782
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBA1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_7639_KD_PCF11_SRP169609	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.57193
GSE89018_11_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TP53	ChEA Transcription Factor Targets	1.0	null
GSE126127_0_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196689
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6MD-01A-41R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GFI1B-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HF-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EIF1AD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04678
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	1.0	0.924313
Perturb_7752_KD_YTHDF2_SRP155278	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.81967
Perturb_3792_KD_MYC_SRP057613	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.50754
MCF7_AMG-900_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154802
C99	DepMap CRISPR Gene Dependency	1.0	2.89477
SW 527	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-92-8065-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_3619_KO_SMARCA4_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.14209
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49225
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286946
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
rostral presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.865301
PANC-08-13	COSMIC Cell Line Gene CNV Profiles	1.0	2.07776
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.5493
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.524217
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-6883-01A-31R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01743
HS-578-T	COSMIC Cell Line Gene CNV Profiles	1.0	2.07776
GSE152666,GSE152668_2_v_1_carm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_8763_KD_ROBO1_SRP158939	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.2851
GTEX-OOBK-2626-SM-2HMKY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42493
ILVBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35679
Tonsil	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
liver_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.935468
IQGAP3	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154927
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.881321
Lung	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.857556
GSE186660_2_v_1_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Bed nucleus of the accessory olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.66839
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
6548_POLR2G_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.19806
A549_Tozasertib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110594
cisplatin_mus musculus_gpl339_gds3099	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02671
Perturb_1055_KD_LINC02015_SRP346389	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.8541
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VP-A87H-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Daptomycin_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00690329
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.826271
GTEX-XLM4-0726-SM-4AT64	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34833
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.62667
layer IIIb of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.25605
MCF7_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199648
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24763
MCF7_Glesatinib(MGCD265)_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.034755
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77693
Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
A549_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195939
MCF7_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0324098
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.38893
GSE206729_3_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_11_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U3ZH-0226-SM-3DB7B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8567
GTEX-PSDG-0726-SM-2I5FN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7554
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.958794
Lung squamous cell carcinoma_LUSC_TCGA-60-2714-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU119	CCLE Cell Line Gene Expression Profiles	1.0	1.56373
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.886957
GSE178255_2_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_3646_KO_HDAC1_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.72556
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73006
PMC11801220-NIHMS2038999-supplement-16.xlsx-Exc-PBX3-gene_PBX3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE151782_1_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate stratum of r10BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20204
143B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.93009
FD-20-OG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.414375
Skin Cutaneous Melanoma_SKCM_TCGA-RP-A6K9-06A-41R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04327
GSE238116_1_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.8384
GSE105169,GSE105175_0_v_1_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270602
Perturb_14652_KD_Ctr9_SRP297013	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.42105
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_8706_KD_SIRT1_SRP267968	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.2349
GSE158834_11_v_5_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-639-ENSG00000181135_ZNF707	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0500591
Perturb_3669_KO_FASTKD_SRP277516	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.8619
GATA2-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Velum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.84
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.933553
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A3-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TFDP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.715
pallidohypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14774
GSE248668_1_v_0_atxn1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_3713_KO_PIWIL1_SRP188921	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.79919
Perturb_2054_KD_CHERP_SRP354316	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.03388
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14641
GTEX-XBEW-0126-SM-4AT66	GTEx Tissue Sample Gene Expression Profiles	1.0	2.68378
rt4	HPA Cell Line Gene Expression Profiles	1.0	1.08969
GTEX-T2IS-2926-SM-32QPO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0241
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.34685
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.3399
SP1	ENCODE Transcription Factor Targets	1.0	null
IGF1R_knockdown_52_GSE16684	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.18462
Perturb_2724_KD_ZNF148_SRP201806	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.46844
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08646
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04357
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06281
hsa-miR-129-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
K562_JNJ-26854165_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155754
GSE231799_2_v_5_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.27153
Perturb_17612_OE_MYC_SRP301619	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	19.2218
GSE146982_7_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC78	DepMap CRISPR Gene Dependency	1.0	5.75436
Perturb_9108_KD_STAT3_SRP363695	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.2927
A549_JNJ-7706621_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122571
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A9FF-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7163_KD_CD81_SRP385887	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.71367
MCF7_Cerdulatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0254887
Perturb_13394_KD_AHR_SRP154013	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.23564
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
HEATR2	Pathway Commons Protein-Protein Interactions	1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.27276
EFCAB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21146
wt1_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl1261_gse15325	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.01997
CD9	Pathway Commons Protein-Protein Interactions	1.0	null
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
COPS5	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_12742_KD_GOT1_SRP282058	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.57839
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35264
GSE140651,GSE140653_2_v_6_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136306
NCIH1836	DepMap CRISPR Gene Dependency	1.0	2.38998
Perturb_5188_KO_Xpo5_SRP109172	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.02965
EC-71-PH39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231833
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of r9BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29358
GSE151782_2_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vagina	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE255432_7_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175039
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5976-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDVN-0626-SM-2I3FP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72388
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE184884_6_v_5_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MECOM-23826213-KASUMI-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WXYG-0226-SM-3NB2Y	GTEx Tissue Sample Gene Expression Profiles	1.0	2.05079
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54D-01A-21R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HEAT	InterPro Predicted Protein Domain Annotations	1.0	null
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23863
D502MG	DepMap CRISPR Gene Dependency	1.0	5.32071
GSE178255_3_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Piriform-amygdalar area, polymorph layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10614
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.51835
MAPK3	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_3623_KO_SMARCD1_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.68335
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22993
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.880812
Perturb_6794_KD_PAF1_SRP060227	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.80861
MYC	ENCODE Transcription Factor Targets	1.0	null
Perturb_10051_KD_PRPF8_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.36274
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UTHO-0011-R6A-SM-3GIJW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830202
GTEX-XV7Q-1326-SM-4BRWM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990969
Perturb_1564_KO_Tnfaip3_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.01207
GSE149870_0_v_1_pfn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A8YF-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC25A36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25266
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HG-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE173997_3_v_0_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.47326
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13473
skeletalmuscle	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.63487
liver	HPA Tissue Protein Expression Profiles	-1.0	-0.97634
mantle zone of r7BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02022
MCF7_Andarine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171221
GTEX-T6MO-0726-SM-4DM58	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831397
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.31658
GSE196699_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCF3	ENCODE Transcription Factor Targets	1.0	null
CORL88	CCLE Cell Line Gene Expression Profiles	1.0	1.64426
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_1_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828133
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.882007
2313287	CCLE Cell Line Gene CNV Profiles	1.0	1.39587
TP73	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03888
GSE181966_0_v_3_has2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PLZ5-1126-SM-3P613	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927126
MCF7_Tanespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173257
Lung adenocarcinoma_LUAD_TCGA-53-A4EZ-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCDC43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02975
Perturb_9884_KD_DDX47_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.36071
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26752
PLS1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE145430_0_v_1_zmat3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE124097_3_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_7265_KO_ASXL1_SRP305063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.97886
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.49
posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14815
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18879
PMC5472759-ncomms15770-s2.xlsx-KIRC_mean_chr8_GISTIC_CN_by_gen-Supplementary_Data_1_TCGA_KIRC_mean_CN_near_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QMR6-0011-R7A-SM-32PKL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876693
NCIH929	CCLE Cell Line Gene CNV Profiles	-1.0	-2.45987
PYGB	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_TG101209_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0256033
6857_PSMC1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.37139
GSE138818_2_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154956
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10735
MCF7_AT9283_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124416
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RM-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6788_KD_NUDT21_ERP122260	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.371
Perturb_14813_KO_Septin2_SRP398422	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
enzalutamide_homo sapiens_gpl570_gse44905	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X5EB-0426-SM-46MVY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867119
Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29493
FLNA	Pathway Commons Protein-Protein Interactions	1.0	null
COPS8	Pathway Commons Protein-Protein Interactions	1.0	null
Sperm principal piece	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.265
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
superficial stratum of the VAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6381
GSE227415_1_v_0_ucp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262628
ORC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61237
MCF7_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117688
GSE162276_2_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NK-A5CX-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.645
RL95-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.57381
VMRCRCZ	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57341
GSE145915_5_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.86887
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.56253
GSE111660_2_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Glesatinib(MGCD265)_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237958
A549_Barasertib_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0095496
Prostate adenocarcinoma_PRAD_TCGA-HC-A6HX-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120869
LTF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05915
PMC8567280-EMBR-22-e53014-s007.xlsx-Sheet1-Nearest_genes_to_BAZ2A-bound_C2-Enhancers_BAZ2A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45168
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
periventricular stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4124
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944995
ZNF479	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63653
PMC12522211-NIHMS2104691-supplement-MMC1.xlsx-SRCAP_DE_genes-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
Cortical amygdalar area, posterior part, medial zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50411
EFM-192A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MCF7_SNS-314 Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182093
MCF7_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211621
CTCF_LNCaP clone FGC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.979006
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12715
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_10044_KD_EFTUD2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.531
SMYD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41098
Nucleus y	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2559
MAPK9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63748
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5432
Perturb_11388_KD_BRG1_SRP261084	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.04216
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4988-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE119603_1_v_0_oxaliplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SP in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04228
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_7460_KD_UPF3B_SRP120604	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.70071
Perturb_7156_KD_ARID1B_SRP366384	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-17.8097
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10625
Medial amygdalar nucleus, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.86806
SK-N-DZ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.935198
Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185516
RAB5C	Pathway Commons Protein-Protein Interactions	1.0	null
HEAT, type 2	InterPro Predicted Protein Domain Annotations	1.0	null
Perturb_13919_KD_TARDBP_SRP295809	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.40922
dorsal part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11624
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.8424
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5509
TP63	ChEA Transcription Factor Targets	1.0	null
GTEX-TSE9-0011-R5A-SM-3DB7J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956294
thyroid_5d	HPA Tissue Sample Gene Expression Profiles	1.0	1.18771
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0106491
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44586
GSE126345_11_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PFKL	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WK11-0926-SM-3NMAU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26722
GSE184902_4_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SNOS-1526-SM-32PLW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907042
MCF7_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0318176
UBQLN1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Daphnetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0324756
MCF7_Aminoglutethimide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177276
NR3C1-21868756-MCF10A-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.24008
NR3C1_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE157555,GSE157556_5_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01434
APTO-253_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0247869
NCIH660	CCLE Cell Line Gene CNV Profiles	1.0	1.34269
GSE168807_0_v_8_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_5649_KD_MYBL2_SRP161768	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00940497
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6326-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Obatoclax Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149699
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16597
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862066
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
TOR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00394
FOSL2	ENCODE Transcription Factor Targets	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMK1-0626-SM-4B65A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37691
CES2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UJHI-0726-SM-3DB92	GTEx Tissue Sample Gene Expression Profiles	1.0	0.959383
COG1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TMMY-1626-SM-4DXTY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892523
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37113
posteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14659
ACTG1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0316859
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56601
A549_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0109243
SNU-387	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MCF7_Gandotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0273248
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980712
NCI-H2291	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOXP2	ENCODE Transcription Factor Targets	1.0	null
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9263655-mmc3.xlsx-ZNF436-AS1-Prediction_catRAPID_ZNF436	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_15383_KD_FGF13_SRP319157	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.21694
Perturb_13393_KD_AHR_SRP154013	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.43528
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55664
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13518_KD_ILF2_SRP077068	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.73123
Perturb_10663_OE_HSPB3_SRP288471	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.67416
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185244
small intestine	HPA Tissue Protein Expression Profiles	1.0	1.20327
Lung squamous cell carcinoma_LUSC_TCGA-56-8624-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_PFI-1_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0120412
MCF7_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148128
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08596
HUTU-80	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200743
Perturb_7316_KO|KD_UPF3A_ERP130416	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.936
Lung adenocarcinoma_LUAD_TCGA-97-A4M2-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Entorhinal area, medial part, ventral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4775
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
A549_Triamcinolone Acetonide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00831176
PMC8034568-HEP4-5-661-s001.docx-2-Supporting_Table_S3_Top_100_differentially_expressed_genes_upon_TEAD4_overexpression_in_Huh7_cells_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.58622
Perturb_943_KO_Sftpa1_SRP246320	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.81075
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46468
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A8O6-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TSE9-2926-SM-3DB77	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935298
MCF7_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237216
Perturb_10233_KO_RN7SK_SRP201495	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.98109
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_7566_OE_NUDT21_SRP327319	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.40653
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
dorsomedial nucleus, terminal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08342
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271827
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-8224-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PG-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Capecitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022129
GTEX-QVJO-0126-SM-3GIK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90242
TUBA1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05147
r7 part of parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16842
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JK-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Aminoglutethimide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.028543
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-1826-SM-3GAE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63931
TP53-23651856-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
17676974-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149641
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21139
Tomivosertib_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.024344
HPBALL	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50867
15260889-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GSE113106_3_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TOMM40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33701
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08849
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.05296
GTEX-R55E-0826-SM-2TC5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09631
MCF7_S3I-201_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185799
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.13793
Pancreatic adenocarcinoma_PAAD_TCGA-L1-A7W4-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114284_1_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Entinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146239
KIAA0368	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A4U1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE144838_1_v_8_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83101
GSE166315_1_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_15396_KD_CSN5_SRP316687	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.6649
COPA	Pathway Commons Protein-Protein Interactions	1.0	null
Primary B cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	2.24179
endometrium_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.47248
SA-32-CC58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273012
Fenofibrate_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0142885
MCF7_SRT3025 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184875
GSE160017,GSE160022_1_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5013
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.871202
Perturb_17242_KD_IRF1_SRP337933	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.55443
Perturb_5647_KD_JQ1_SRP142503	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.06222
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Fulvestrant_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163038
Perturb_4669_OE_Wdr5/Trp53|Wdr5_SRP324834	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.80685
KNTC1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S4Q7-1526-SM-3K2AG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22522
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE178255_1_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8S1-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_3979_KO_ZKSCAN3_SRP315081	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.35239
KIF5B	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139563
GSE248858_1_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WFJO-0226-SM-3GIKW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50875
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013131
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IK-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X8HC-0526-SM-4E3JA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853444
MCF7_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0268992
Perturb_7237_KO_CDK8/CDK19_SRP271652	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.36364
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	113.278
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_18496_KD_LINC00881_SRP362016	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.84957
Perturb_16794_KD_SPIN1_SRP171066	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.35407
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.460214
HCC-78	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EJ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAB11B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OHPM-1626-SM-2HMK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14095
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07034
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.37903
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HM7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
MCF7_Abexinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00849704
Paragigantocellular reticular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69287
CLTCL1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PX3G-2626-SM-2I3EG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38478
DCTN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72191
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00725
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
DRG1	Pathway Commons Protein-Protein Interactions	1.0	null
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.81726
GSE168807_0_v_7_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140937,GSE140938_0_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE60691_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PRPF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8179
8-Hydroxyquinoline_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00530048
Kidney renal clear cell carcinoma_KIRC_TCGA-MM-A84U-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYH14	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17006
Perturb_6872_KD_YAP1/WWTR1_SRP323378	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.47299
medial amygdala, anterodorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08659
MCF7_Tubastatin A HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014191
GTEX-SUCS-1626-SM-32PLS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837054
GTEX-XYKS-0526-SM-4BRW2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12903
GTEX-P4QS-0526-SM-2I3ET	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912597
MYO1B	Pathway Commons Protein-Protein Interactions	1.0	null
NC-01-ET52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.368893
GSE231799_2_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OE-75-WF43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282737
GTEX-OXRL-2626-SM-2I3F1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88956
K562_Triamcinolone Acetonide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134366
ZNF521	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08096
Lung squamous cell carcinoma_LUSC_TCGA-85-A4QQ-01A-41R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7064337-elife-51373-supp2.xlsx-652_genes_up-regulated-List_of_652_genes_up-regulated_after_PHF19_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH2291	DepMap CRISPR Gene Dependency	1.0	2.24675
K562_WHI-P154_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151127
GTEX-RVPU-0011-R5A-SM-2XCAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875966
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334953
A549_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148959
GSE201309_5_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32133
KG-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.65213
OPM2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77534
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3734
GTEX-XUJ4-1226-SM-4BOPD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861112
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-5398-01A-02R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14087
GSE157555,GSE157556_4_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KAT2A	ENCODE Transcription Factor Targets	1.0	null
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.38393
GTEX-OHPL-1626-SM-2HMIR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28065
MCF7_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0316349
CIDEC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0732
Perturb_6432_OE_RBFOX1_SRP372391	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.10438
MCF7_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0222271
Perturb_1195_KD_Mcm6_SRP293272	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.15131
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SW 480	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.546344
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014515
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42606
SP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.906613
dorsolateral prefrontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0501
BPNT1	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7229-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12366_KD_SLC39A7_SRP274341	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-16.2408
Cortical amygdalar area, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46301
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114076
SP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.916534
Perihypoglossal nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.65453
Sarcoma_SARC_TCGA-DX-A3UE-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146982_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RAB11A	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13372_KD_RPRD1B_SRP362755	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.8171
GSE109565_12_v_4_glyphosate_human	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42764
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.41124
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.2555
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08783
Perturb_15069_KD_Twist1_SRP150075	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	19.2218
KP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.900752
GSE112365_0_v_1_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_7_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MCF7_Luminespib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00939673
MCF7_Sorafenib Tosylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164939
MG63	DepMap CRISPR Gene Dependency	1.0	2.04253
Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5K1-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ARCN1	Pathway Commons Protein-Protein Interactions	1.0	null
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.253507
Perturb_13569_KD_Crebl2_SRP214575	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.42761
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28407
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04456
A549_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158233
GTEX-S341-0226-SM-2XCAX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64559
thyroid gland	HPA Tissue Gene Expression Profiles	1.0	1.54145
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nih 3T3	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.15168
GSE186767_1_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_9411_KD_Pcbp1_SRP251371	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.45068
CAL-120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39033
LAP3	Pathway Commons Protein-Protein Interactions	1.0	null
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.895319
HCFC1	ENCODE Transcription Factor Targets	1.0	null
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.918277
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
MIEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13717
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
rostral subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36821
EPB41L2	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Ramelteon_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0503434
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.27912
TBX2-33478486-IMR90-HUMAN-LUNG	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_7852_KD_XAB2_SRP193107	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.9919
Perturb_13785_OE_IL10RB_SRP329434	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.54187
Perturb_8060_KO_TP53_SRP182675	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.01887
PMC10290283-biol-2022-0622-sm3.pdf-328-ZNF557_ZNF557	Rummagene Transcription Factor Associations 2026	1.0	null
GSE100102_0_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WDR11	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XUZC-0126-SM-4BOO6	GTEx Tissue Sample Gene Expression Profiles	1.0	3.06153
NUP62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24323
MCF7_Carmofur_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146668
GSE200839,GSE233826_2_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Amisulpride_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0329396
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.855949
Medial amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11983
Perturb_11445_KD_GATA2_SRP178865	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.04159
GSE200099_3_v_1_honokiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nucleus of the lateral olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42024
FOXI1-33610681-GES1-HUMAN-GASTRIC-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
OB-17-DQ74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315355
K562_Baricitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165194
GTEX-PWOO-0926-SM-2I3EC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32892
DA-17-XI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269643
EEF1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	9.0061
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.880123
GSE98831_1_v_0_brca1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARRB1	Pathway Commons Protein-Protein Interactions	1.0	null
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE131588,GSE131690_1_v_0_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.418081
ESYT1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE109530,GSE109531_2_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
lateral parabrachial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.910323
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	148.524
Brain Lower Grade Glioma_LGG_TCGA-HT-A5R7-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE235596_0_v_1_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EFE184	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68843
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_341_KD_EGFP_SRP076553	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
NMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39559
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JA-63-WB39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234096
GSE193993_1_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE130383_1_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.986777
DNTTIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04205
GSE114284_1_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE248887_0_v_1_dkk1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7466_KD_ARIEL_SRP136083	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.9295
GTEX-RM2N-0526-SM-2TF4N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57373
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7130-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
irf8_00000000_splenic_cd11bplusgrdash1_hdash2b_gen_background_lof_mouse_gpl6887_gse39228	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.548782
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intermediate part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23686
SNU119	CCLE Cell Line Gene CNV Profiles	1.0	2.46056
GTEX-P44H-0426-SM-2XCEZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32532
GTEX-XPVG-2526-SM-4B66D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02622
Acute Myeloid Leukemia_LAML_TCGA-AB-2992-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0274733
CHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.848586
Perturb_8837_KO_RBM12_SRP369839	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.47868
Perturb_13662_KD_E2F1_SRP225180	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.05758
ANXA11	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_15394_KD_RRM2_SRP155857	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.7982
K562_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149613
MCF7_M344_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121832
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Microglial cell_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GTEX-T2IS-0626-SM-32QP6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17816
GSK3B_knockdown_209_GSE35351	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.65206
SW1573_LUNG	CCLE Cell Line Proteomics	1.0	7.90619
inner SZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4985
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	122.084
GSE158502,GSE158506_3_v_0_fat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SRI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41522
stratum radiatum of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01538
GSE228413_4_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26497
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.829914
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38164
Perturb_7383_KO_SMG7_ERP122822	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.23131
hsa-miR-506	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE205163,GSE205164_2_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_MLN8054_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137028
shell part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04207
SW1463	DepMap CRISPR Gene Dependency	1.0	9.56936
Perturb_6759_KO|KD_IER5_SRP103746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.68415
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8275_KD_SF3A3_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.9612
nucleus subceruleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.853061
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75373
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08849
XPO1	Pathway Commons Protein-Protein Interactions	1.0	null
SMAD4-21741376-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COPS7B	Pathway Commons Protein-Protein Interactions	1.0	null
CFL1	Pathway Commons Protein-Protein Interactions	1.0	null
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.96316
MCF7_PCI-34051_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0278666
MCF7_Lomustine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224937
GTEX-Q2AG-0011-R11A-SM-2HMKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08889
K562_Thalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150787
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
VPS35	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176378
Perturb_2167_KO_Sirt3_SRP403451	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.38183
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE247862,GSE247863_2_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WZTO-0011-R11A-SM-4E3K9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887341
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.579679
SG in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.14399
A549_Bosutinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144984
ACSL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05623
ZNF251	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32379
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.49044
Perturb_10172_KO_TOX4_SRP300474	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.33536
MCF7_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016263
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860567
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	141.427
accumbens nucleus, core domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03831
TPM3	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.986687
YKG-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_299_KD_TPRX1/TPRX2/TPRXL_SRP361145	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.25923
Perturb_7403_KD_HNRNPA2B1_SRP010280	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.42216
20077526-TableS5	GeneSigDB Published Gene Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-97-A4LX-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7315_KO_UPF3A_ERP130416	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.57879
16728581-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-NL3H-0011-R7a-SM-2I3G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829063
LASP1	Pathway Commons Protein-Protein Interactions	1.0	null
arcuate nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.934157
ELMO1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_SRT2104_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187368
lymph node	HPA Tissue Protein Expression Profiles	-1.0	-1.56256
GSE202284,GSE202289_5_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0284875
GTEX-SJXC-0526-SM-2XCFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53846
MCF7_Tozasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0246812
MCF7_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.019351
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131763
Perturb_8919_KD_ARID1A/P300_SRP256204	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.4166
KIF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09943
FASN	Pathway Commons Protein-Protein Interactions	1.0	null
lateral nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.873824
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X261-3226-SM-3NMC3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849407
GDI1	Pathway Commons Protein-Protein Interactions	1.0	null
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.863059
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57742
BE-57-VZ17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219125
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.880812
KLC4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE154767_4_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17105
Perturb_7157_KD_NEAT1_SRP366384	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
A549_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143899
GTEX-XPT6-2026-SM-4B64V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963573
Perturb_11427_OE_FOSL1_SRP360169	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.87005
GTEX-N7MS-1626-SM-3LK5F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843474
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01826
MCF7_TG101209_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133142
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13688
MCF7_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156749
GTEX-U3ZN-0626-SM-3DB7U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859493
GSE140322_3_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WL46-0126-SM-3TW8I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27596
GSE152441,GSE152442_7_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9270251-mmc2.xlsx-2_Filtered_DEGs_Control_vs_KD_2-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OIZG-0226-SM-2TC5L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44697
Perturb_12655_KD_Yap1/Wwtr1_SRP212072	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
inner CP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.980348
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TMPO	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
periventricular stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25808
GTEX-QDT8-0526-SM-3NMD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12178
Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.36127
Perturb_15379_KD_NSD2_SRP269000	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.639
MCF7_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150843
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_7537_KD_RREB1_SRP265233	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.31951
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-1434_proliferation_genes-ZNF766_ZNF766	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-0011-R11A-SM-3MJFO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12584
MCF7_Abexinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211312
SEC61B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44592
MCF7_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0418768
GSE226285_3_v_0_nr0b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8626-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXA2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZFP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07871
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142684_3_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BL405 (RFC3)	NURSA Protein Complexes	1.0	null
GTEX-XQ8I-2126-SM-4BOOM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833854
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 3 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28393
GTEX-XUJ4-0126-SM-4BOP7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843928
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.68984
GSE142430_2_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Belinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235821
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZK-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34209
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165383
GSE162276_2_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EZR	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.03149
SNU-C1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MCF7_Meprednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0281138
Perturb_6700_KD_ALAL1_SRP148427	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.71499
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UKE-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.959481
GSE111138,GSE111149_1_v_0_runx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SEPT9	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Dasatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182724
GSE149903_3_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.96221
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5117-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S33H-0326-SM-4AD6N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10166
MXI1	ENCODE Transcription Factor Targets	1.0	null
Perturb_11974_KD_Esrp2as_SRP101942	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.31863
Perturb_2628_OE_HPGD_SRP292282	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.08615
MCF7_Tazemetostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129551
Perturb_17423_KO_Cic_SRP126501	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.2582
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.36365
ovary	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.835932
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.16472
superficial stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.20162
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27722
GSE158834_12_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.823934
TTC39B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE220520_1_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Ciliary pocket collar	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.58
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.68772
KA-00-HF91_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261387
thyroid	GTEx Tissue Gene Expression Profiles	1.0	2.18987
Esophageal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.802
MCF7_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0187041
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193073
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.1807
ACTA2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE200982_0_v_2_plac8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.4781
AGR2	Pathway Commons Protein-Protein Interactions	1.0	null
r8 part of nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5144
medial tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37624
ZC3H15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62619
RAC2	Pathway Commons Protein-Protein Interactions	1.0	null
COPB1	Pathway Commons Protein-Protein Interactions	1.0	null
ANPEP	Pathway Commons Protein-Protein Interactions	1.0	null
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.865789
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.9716
r5 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07695
Perturb_13860_KD_TBX2_ERP107244	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.62278
Perturb_5661_KO_ID2_SRP336141	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.3188
Perturb_9520_KO_Ift140_SRP131479	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.92927
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.836708
COPS2	Pathway Commons Protein-Protein Interactions	1.0	null
PPP2R1A	Pathway Commons Protein-Protein Interactions	1.0	null
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
NCI-H2596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
PDXK	Pathway Commons Protein-Protein Interactions	1.0	null
CUL4A	Pathway Commons Protein-Protein Interactions	1.0	null
GLI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56002
ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.075708
GTEX-SN8G-1526-SM-4DM79	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28535
rosiglitazone_mus musculus_gpl8321_gds4021	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_2124_KD_NFKBIA_SRP285793	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.25751
MCF7_Nintedanib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275559
AC-36-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28811
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.68315
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.880812
Perturb_12075_OE_Prmt1_SRP134253	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.59851
GTEX-QV31-0726-SM-3GAEG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42809
PDCD6	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PECAPJ49	CCLE Cell Line Gene Expression Profiles	1.0	1.46734
GTEX-OHPN-0011-R2A-SM-2I5FB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987064
lateral trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5277
superficial stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19642
Perturb_13373_KD_RPRD1B_SRP362755	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.33432
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24456
CAL-148	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.976732
Perturb_12997_KO_rs2431697_ERP121303	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.57868
GSE114284_4_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
RH30	DepMap CRISPR Gene Dependency	1.0	2.28279
MCF7_KW-2449_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148558
NEDD4	Pathway Commons Protein-Protein Interactions	1.0	null
LUDLU1	CCLE Cell Line Gene Expression Profiles	1.0	1.54021
Brain Lower Grade Glioma_LGG_TCGA-HT-8015-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184884_6_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STAT3	Pathway Commons Protein-Protein Interactions	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
shell of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3549
Perturb_14177_KO_CD33_SRP387539	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.8693
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_FLLL32_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0358269
GSE180200,GSE180201_12_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U3ZM-0126-SM-3DB8M	GTEx Tissue Sample Gene Expression Profiles	1.0	2.31789
stratum pyramidale of caudal CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.48396
Perturb_6750_KO|KD_IER5_SRP103746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.63452
Perturb_7557_Mut_ASXL1_SRP305063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.7617
MCF7_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0289268
periventricular stratum of r6BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.21387
Perturb_13948_KD_CDK4/CDK6_SRP258989	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.85958
Cycloplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
ACACA	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Hesperadin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0288557
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1509
GSE89018_11_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RCC4	CCLE Cell Line Gene Expression Profiles	-1.0	-2.14485
UC-00-QA88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.486552
perimammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04499
IRF4	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7752-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211177,GSE211178_8_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999296
PGAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10596
hsa-miR-1276	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
K562_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013808
MCF7_GSK-LSD1 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0323218
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.542393
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A4Z3-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Radotinib_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0302063
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18879
Pancreas-pancreatic acinar cell	Tabula Sapiens Gene-Cell Associations	1.0	15.8478
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09054
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16863
CTNNB1-20460455-HCT116-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PQ-2626-SM-33HC9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02759
GSE137954_4_v_2_smyd3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE255680_1_v_0_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6795-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
central medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.25226
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147354
K562_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163346
Perturb_11533_KD_ATAC1_SRP109127	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GSE193351_1_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.83539
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GOLGA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15557
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.24339
Perturb_4396_KD_SUV39H1_SRP290196	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.31583
Perturb_3629_KO_HDAC3_SRP355605	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.66342
YY1-23942234-MYOBLASTS AND MYOTUBES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_14907_KO_Pgr_ERP140354	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	17.279
Tirabrutinib_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00733634
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A66X-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
NIHOVCAR3	DepMap CRISPR Gene Dependency	1.0	2.2384
Perturb_7328_KO_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.1445
GSE215086_0_v_2_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.8187
Perturb_3881_OE_HLAC_SRP363812	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.93522
GSE165704_0_v_1_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0239111
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206395
GTEX-S4P3-0226-SM-3K2BD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50624
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51743
PLIN3	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Barasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130169
K562_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153567
GSE217776,GSE217829_1_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
KNS-62	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TE-8	COSMIC Cell Line Gene CNV Profiles	1.0	2.07776
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41021
GTEX-Q734-2026-SM-3GADA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24054
C2BBE1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.854557
layer 1 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.99192
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.954609
superficial stratum of AHy	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15386
GTEX-RUSQ-0226-SM-47JWT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01546
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05027
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A449-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE175683_3_v_2_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
r7 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27336
PBX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149903_3_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
AC-28-RT00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275511
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.30258
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-2.07269
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.848586
GSE158834_11_v_6_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8514-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SA-01A-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16123
HD-89-HC56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235351
GTEX-V955-0426-SM-3GAEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2417
Perturb_15515_KD_E2F2_SRP314859	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.64583
Perturb_401_KD_RNF113A_SRP201913	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DU 145	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
PHGDH	Pathway Commons Protein-Protein Interactions	1.0	null
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-0.705663
NAP1L1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_10120_KO_RNH1_ERP021688	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.1778
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80822
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SCP2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE233679_5_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07683
periventricular stratum of r5Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1381
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04906
GSE220806_0_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DC-23-UM36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24888
A549_Lapatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134388
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	153.506
Brain Lower Grade Glioma_LGG_TCGA-HT-7880-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE113106_0_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149903_5_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205575
MCF7_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01396
GSE245270_1_v_5_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183643
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-WL-A834-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE126345_7_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173873_10_v_3_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IC-05-AW29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237517
FA-36-VA24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269665
EAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1186
Perturb_7180_KO_TrEx_SRP163035	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.22064
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_3628_KO|KD_ARID2|SMARCA4_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.50166
GTEX-Q2AI-1126-SM-48U19	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847508
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.9461
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6935-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X4XX-2926-SM-3NMB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13087
PSN1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.867804
MCF7_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136912
SPI1	ENCODE Transcription Factor Targets	1.0	null
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17440_Mut_Akt_SRP366791	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.33928
MT-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217156_2_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POU2F2	ENCODE Transcription Factor Targets	1.0	null
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907709
GSE101239_4_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE157594_6_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5390115-mmc7.xlsx-DE_Lists-H1-ECs_Experiment_2_H1-EC2_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21393
GTEX-XYKS-1326-SM-4BRUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16793
Nucleus of the lateral olfactory tract, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.70006
GTEX-U4B1-1026-SM-4DXT1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853811
GTEX-RVPV-1226-SM-2TF73	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29581
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.76312
GTEX-WFG8-1326-SM-4LVN3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841053
Eyespot apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.669
gallbladder	HPA Tissue Protein Expression Profiles	1.0	1.20327
Adrenocortical carcinoma_ACC_TCGA-OR-A5JR-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CALR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82728
GSE200673,GSE200691_2_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Postpiriform transition area, layers 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08513
mantle zone of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04382
NR3C1	ChEA Transcription Factor Targets	1.0	null
GSE101239_3_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3443-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WHSE-0011-R11A-SM-3P5YY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.94144
Perturb_5563_KO_KDM4C_SRP375293	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.70099
K562_Cerdulatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181599
mediodorsal nucleus of thalamus_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.47962
Perturb_5870_KD_Cpsf7_SRP336206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.94319
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23168
GTEX-QVJO-1325-SM-2S1QX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04318
GSE205163,GSE205164_9_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QEG5-1126-SM-33HC2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894184
GTEX-SSA3-0326-SM-32QPS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14316
GSE239844_11_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.80475
GNE	Pathway Commons Protein-Protein Interactions	1.0	null
KNDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40422
Perturb_13949_KD_CDK4/CDK6_SRP258989	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.62663
GSE200839,GSE233826_2_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
stomach_3a	HPA Tissue Sample Gene Expression Profiles	1.0	0.877597
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.5513
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.89709
GTEX-WFG8-0426-SM-3GILD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20562
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
testis_7b	HPA Tissue Sample Gene Expression Profiles	1.0	0.916785
SPTAN1	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39711
GSE189609_1_v_0_hax1_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Cerdulatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016123
GTEX-OXRK-0626-SM-2HMJ5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28796
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845046
GSE95685_2_v_5_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ATP6V1B2	Pathway Commons Protein-Protein Interactions	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
GTEX-TSE9-0011-R7A-SM-3DB7P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868688
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270532
HCC1937	CCLE Cell Line Gene CNV Profiles	1.0	1.85178
periventricular stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03774
Perturb_15382_KD_FGF13_SRP319157	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.11517
medial amygdala, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.72861
Perturb_7871_KD_PCF11_SRP258098	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.0364
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11575_OE_YAP_SRP273175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.80359
Lung adenocarcinoma_LUAD_TCGA-86-8359-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918621
A549_AZ 960_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017199
HCC1143	CCLE Cell Line Gene CNV Profiles	1.0	1.44973
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	1.20327
K562_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138198
MT-ND5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12159
ILF3	Pathway Commons Protein-Protein Interactions	1.0	null
VIIIA	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.17199
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.67111
Perturb_3841_KD_NFE2L2_ERP105460	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.19282
GSE191174_0_v_1_ccdc92_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE184892_7_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.477246
AQP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09636
GTEX-XUW1-0826-SM-4BOP6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00465
MCF7_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0312611
Macropinosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.11
GSE100316_7_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020479
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.53888
GTEX-NPJ7-0011-R5a-SM-33HBK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05826
SNU2535	DepMap CRISPR Gene Dependency	1.0	2.22272
Perturb_15471_KD_KLF5_SRP256723	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.41274
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-RVPV-0011-R11A-SM-2TF6F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1169
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null