association	dataset	threshold value	standardized value
SYNCRIP	Pathway Commons Protein-Protein Interactions	1.0	null
Primary motor area, Layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08345
MYOG	ENCODE Transcription Factor Targets	1.0	null
PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.59873
navicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84373
YY1_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5183_KD_Ssrp1_SRP094584	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EM-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate stratum of r4Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02696
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.453148
TAF7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FMO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16955
Granular lamina of the cochlear nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10363
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42971
GSE235701,GSE261434_2_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SOX17-20123909-XEN-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MRPL32	Pathway Commons Protein-Protein Interactions	1.0	null
PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TRUB2	Pathway Commons Protein-Protein Interactions	1.0	null
ribosomal subunit	GO Cellular Component Annotations 2015	1.0	null
MRRF	Pathway Commons Protein-Protein Interactions	1.0	null
protein complex subunit organization	GO Biological Process Annotations 2015	1.0	null
GSE212486,GSE212488_2_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19144
chlorambucil_homo sapiens_gpl570_gds2970	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_3262_KO_VHL_SRP337931	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.14154
GTEX-NFK9-1626-SM-3LK5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07736
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of SePal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66088
TE441T	CCLE Cell Line Gene CNV Profiles	-1.0	-2.70801
7439_RPL15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.627386
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.045465
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3440-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rhino-Deadlock-Cutoff Complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.887
GSE228106_3_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
cellular process	GO Biological Process Annotations 2015	1.0	null
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.50339
9482_UBA52_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.87224
Kco	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.165
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_665_KO_Myc_SRP093784	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.56783
ZNF689	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72627
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.910669
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MRPS28	Pathway Commons Protein-Protein Interactions	1.0	null
GSE196505,GSE196507_1_v_2_kdm2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5578490-pgen.1006879.s017.xlsx-Top_ETV1_downregulated_genes-Gene_Symbol_ETV1	Rummagene Transcription Factor Associations 2026	1.0	null
membrane-enclosed lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.056184
GSE206516,GSE206518_6_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.28176
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5886-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1436
OCIAML2	DepMap CRISPR Gene Dependency	1.0	2.00439
Perturb_12699_KO_Ezh2_SRP222765	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.7667
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01689
RABL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04914
7206_RCL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.830224
Bladder Urothelial Carcinoma_BLCA_TCGA-S5-A6DX-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CE-15-YU05_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.567814
Alate adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.837
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.27442
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
Acquired Immunodeficiency Syndrome	HuGE Navigator Gene-Phenotype Associations	1.0	null
mantle zone of r5Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.79245
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-522	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27647
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4712-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.844462
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
H3K18ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NALM6	DepMap CRISPR Gene Dependency	1.0	2.07333
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.028
cellular macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KYSE-70	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.57265
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45553
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2135_DDX6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.713191
GTEX-XQ3S-0626-SM-4BOOB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878773
HENMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04415
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.24556
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.3549
7462_RPL35A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.813947
snoutepidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.23847
Rectum adenocarcinoma_READ_TCGA-DY-A1DC-01A-31R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZR751	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.984695
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94163
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_11013_KO_Plat_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.73206
7576_RSL1D1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.655743
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24521
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38991
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318105
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5575
SMARCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17165
ChIP_JARID1A_20064375	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.20044
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
endometrium	HPA Tissue Protein Expression Profiles	-1.0	-0.813558
endometrium_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.979212
Sarcoma_SARC_TCGA-DX-A8BZ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6768
r2 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31992
H3K9ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01734
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE228181_2_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PHYKPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22596
hsa-miR-3144-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Perturb_7599_KO_CTNNB1_ERP109990	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.94633
Prostate adenocarcinoma_PRAD_TCGA-FC-A4JI-01A-11R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.21752
GTEx Heart 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-8.17189
Childhood acute lymphocytic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.656
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49277
H3K4me1_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.653
CDK8_knockdown_147_GSE32108	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.95855
GTEX-XGQ4-2026-SM-4AT6G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79462
Posterior parietal association areas, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01386
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HeLa cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	0.903679
anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13353
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92615
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.0603
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2351
Perturb_13959_KO_YAP1_SRP194022	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.3897
ABCB7	Pathway Commons Protein-Protein Interactions	1.0	null
LUDLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.34459
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05739
abnormality of the head	GWASdb SNP-Phenotype Associations	1.0	0.136187
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
10040_ZCCHC9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.84424
Lung adenocarcinoma_LUAD_TCGA-05-4397-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4672	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.32591
Sto	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.032
CE-69-HJ13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.329615
FGFR1_drugactivation_149_GSE32316	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.09873
FCF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03469
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.750718
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07301
PAX5_CH12.LX_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG8-1926-SM-4LVM1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89729
Mitochondrial translation	Reactome Pathways 2024	1.0	null
layer 2 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37566
neoplasm by anatomical site	GWASdb SNP-Phenotype Associations	1.0	0.110767
layer 1 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53743
r2 part of anteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3102
FASTKD2	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01791
MRPS18B	Pathway Commons Protein-Protein Interactions	1.0	null
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2267
RELA	ENCODE Transcription Factor Targets	1.0	null
IRAK4_Deficiency_GDS2641_653_mouse_Embryonic fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Sporoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.792
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE151083_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.88045
mitochondrial inner membrane	GO Cellular Component Annotations 2015	1.0	null
GSE245134_0_v_1_atg5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-607	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GTEX-T5JW-1126-SM-4DM5V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19935
Ribosome	KEGG Pathways 2026	1.0	null
mitochondrial matrix	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
disease	GWASdb SNP-Disease Associations	1.0	0.037397
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3RB-01A-12R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DA-40-HO94_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260199
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.856588
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Mitochondrial small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.066
BRCA1	ENCODE Transcription Factor Targets	1.0	null
Perturb_6512_KD_ALKBH5_SRP090686	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.32785
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837435
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-70	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830909
Brain Lower Grade Glioma_LGG_TCGA-HT-A61C-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.343104
9818_WDR3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.517655
GTEX-QDT8-0006-SM-32PL3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07413
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54E-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2906_OE_MACROH2A2_SRP333362	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.19837
Organellar large ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28807
TSTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34214
pontine nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51727
Perturb_17751_OE_Cdk8_SRP093265	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.86496
medial amygdala, posterodorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.93007
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46996
mitochondrial part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F6	JASPAR Predicted Transcription Factor Targets	1.0	null
ChIP_SOX17_20123909	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4634137-ncomms9549-s7.xlsx-ZF_Hair_cell_data-Unnamed_1_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.978868
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0863
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4566_KD_Setdb1_SRP172038	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.3391
nih 3T3	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.909403
abnormality of the face	GWASdb SNP-Phenotype Associations	1.0	0.160394
PPP2R2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16122
Perturb_6840_KD_lncLUCRC_SRP218870	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.47534
organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
DAP3	Pathway Commons Protein-Protein Interactions	1.0	null
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05202
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-21-1077-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.27258
YY1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
icSARS CoV_30Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.89854
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.954771
Perturb_18046_KO_Ocln_SRP304697	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.99204
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4962_KO_Dot1l_SRP214101	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.08729
r5 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89939
H3K79me2_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8288
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0129
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.976854
Dorsal peduncular area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06841
YY1-23942234-MYOBLASTS-AND-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15826
GTF2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5729_NOC2L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.725216
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	185.608
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16819_KD_HDAC1_SRP199194	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.106
GTEX-O5YU-0008-SM-4E3I7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40261
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.48504
retrotrapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02997
MAPK14_KD_GDS2693_533_mouse_A431	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE149124,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_14741_OE_ADAR1_SRP250165	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.5742
HOXC10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5586
intermediate stratum of r4Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2426
9818_WDR3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.601822
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1505
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19392
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.990939
7438_RPL14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.952924
496100326_TCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.08407
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4921_MDN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.621274
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1	ENCODE Transcription Factor Targets	1.0	null
disease of cellular proliferation	GWASdb SNP-Disease Associations	1.0	0.109349
GOLGB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06893
OVKATE	CCLE Cell Line Gene CNV Profiles	1.0	1.68272
NANOG-16518401-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
MECOM-23826213-KASUMI-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.28671
SLC25A12	Pathway Commons Protein-Protein Interactions	1.0	null
MRPL37	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-548aj	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06986
7503_RPS15A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.624874
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FARS2	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24607
PDK1_knockout_265_GSE42187	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.68137
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25029
BT20_BREAST	CCLE Cell Line Proteomics	1.0	2.00697
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7444_RPL19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13998
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18173
Mitochondrial translation termination	Reactome Pathways 2014	1.0	null
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.971495
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim22_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIH1D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38386
9841_WDR75_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.57459
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.34041
Perturb_7555_KD_SP1_SRP303813	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.95219
abnormal genital system morphology	GWASdb SNP-Phenotype Associations	1.0	0.110767
H3K79me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
7491_RPP30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.583009
CTCF	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SARS-CoV MA15_Day2-C57BL6_None_GSE50878	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	0.955006
GTEX-S95S-0726-SM-4B64H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1095
A-431	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.887017
NCOA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46248
Perturb_13179_KO_Mof_SRP060636	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.50942
HARA	CCLE Cell Line Gene Expression Profiles	1.0	1.90384
GTEX-P4QS-1326-SM-3NMCD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03838
GSE150634_1_v_0_cd28_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8408-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02583
Perturb_16467_KO_Ncstn_SRP149348	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.25927
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-4_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
6534_POLR1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.719182
mantle zone of r6Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64691
embryoday8.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.863564
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Memory Disorders	CTD Gene-Disease Associations	1.0	1.17761
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
SIN3A_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BE-27-RQ61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.478714
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inner CP in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27532
GTEX-U4B1-1026-SM-4DXT1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874196
mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.263485
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_10364_KD_Setd2_SRP184682	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.61929
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-K1-A6RV-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
AASS	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23965
GABPA_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TE14	CCLE Cell Line Gene Expression Profiles	1.0	1.7167
TFAP2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17425
MRPL43	Pathway Commons Protein-Protein Interactions	1.0	null
PMC3371315-NIHMS350140-supplement-8.xls-MCF7-T47D-SK-453_Down_MCF7-T47D-Supplementary_Table_1_ER-positive_FOXA1_signature_Genes_decreased_only_in_MCF7_and_T47D_cells_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.702491
anteromedial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1996
striatum_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02224
7480_RPL8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.946964
abnormality of the genital system	GWASdb SNP-Phenotype Associations	1.0	0.096062
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17605
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HT-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
GSE229309,GSE229314_4_v_1_elavl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01539
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.12506
DKC1	Pathway Commons Protein-Protein Interactions	1.0	null
Accessory facial motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.34483
7499_RPS11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.67449
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07515
Amygdala	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.10692
Lung adenocarcinoma_LUAD_TCGA-44-5643-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AA-01-JO26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204597
Striatum-like amygdalar nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03269
Perturb_10956_KO_Adamts15_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.47187
Tooth enamel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.835
PMC5640240-ppat.1006668.s013.xlsx-BETA4-379_common_elements_in_shEP400-1_BETA_shEP400-3_BETA_shMYCL_BETA_and_shEP400-2_BETA_BHLHE23	Rummagene Transcription Factor Associations 2026	1.0	null
LONP1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166805
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.295
AA-48-XT80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.465106
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.7181
mRNA_NIPBL_20720539	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Perturb_16665_KO_Slc27a2_SRP186493	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.88815
LOVO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.24027
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.37857
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RN64-2326-SM-48FDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62644
primary motor-sensory cortex (samples)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0078
KSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36967
outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.255107
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55226
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125782_3_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HEC50B	CCLE Cell Line Gene Expression Profiles	1.0	1.49192
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00762
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
septopallidal shell area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60562
1483_CENPJ_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.51134
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.45949
MRPL45	Pathway Commons Protein-Protein Interactions	1.0	null
SUCLA2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16126
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.89681
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
BHY	CCLE Cell Line Gene Expression Profiles	-1.0	-1.92019
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.46071
Perturb_9457_OE_Rnaseh1_SRP182028	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.03709
GSE152050,GSE152052_1_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
MRPL18	Pathway Commons Protein-Protein Interactions	1.0	null
MYC-19030024-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial ribosome	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
heart muscle	HPA Tissue Gene Expression Profiles	1.0	1.80617
Perturb_4807_KO_Atp2b4_ERP004375	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.09945
Taenia tecta, dorsal part, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31365
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.848103
YARS2	Pathway Commons Protein-Protein Interactions	1.0	null
organ system cancer	GWASdb SNP-Disease Associations	1.0	0.121443
GSE145249_1_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE189789_0_v_1_oridonin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7923339-13046_2021_1884_MOESM7_ESM.xlsx-Overlap-3_UTR_lengthened_genes_in_CPSF6_KD_Huh7_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.0961
paraterminal gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.883321
HEC265_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	2.3096
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66879
CIITA-18437201-Raji B cells and iDC-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GATA2_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG5-0926-SM-2TC64	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11127
DDX5	Pathway Commons Protein-Protein Interactions	1.0	null
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
Perturb_17551_KD_PHF14_SRP354496	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.64273
GSE240896,GSE240899_3_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE132408_1_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.08962
DA-45-PU65_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24931
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Translation	Reactome Pathways 2024	1.0	null
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.26868
Perturb_2196_KO_Tnfaip3_SRP103751	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
SET2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
5733_NOL11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.584116
Sieve tube	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.78
PMC3253802-pone.0029922.s001.pdf-116-ZBTB41_ZBTB41	Rummagene Transcription Factor Associations 2026	1.0	null
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	1.0	1.37238
Perturb_8490_KD_CAG/CUG_SRP119324	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
THAP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16_AATF_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.647253
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9651
inner SZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.991331
GABP-17652178-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3391
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.6305
OVCAR-8/ADR cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-0.916169
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.5517
H3K9ac_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
LRPPRC	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VMRCLCP	CCLE Cell Line Gene CNV Profiles	1.0	1.83373
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19708
MRPS17	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UE-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPS16	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIRT6	ENCODE Transcription Factor Targets	1.0	null
DHFR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14562
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MMADHC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07134
SP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09085
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7576_RSL1D1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.526006
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ezz	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.035
5230_MRPL47_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-1.01277
Perturb_15325_KO_Setd2_SRP251920	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.33605
MRPS22	Pathway Commons Protein-Protein Interactions	1.0	null
outer CP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19986
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.505519
igr39	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.457
RAB39A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35908
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.89579
Lung adenocarcinoma_LUAD_TCGA-49-4487-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_10059_KD_XRN2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.2594
GTEX-OHPM-1026-SM-3LK74	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931931
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.830604
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.23342
SNU626	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53825
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61969
7500_RPS12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.664352
MAX_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXP3_ABLATION_GDS2525_64_mouse_mature regulatory T cells (Treg)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Perturb_245_KO_Clic4_SRP318761	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.94668
GTEX-OXRK-0008-SM-3NB28	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17334
t47d	HPA Cell Line Gene Expression Profiles	1.0	1.16789
ALEXANDERCELLS	CCLE Cell Line Gene Expression Profiles	-1.0	-3.3222
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17637
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A59E-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of AOV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3191
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65J-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02308
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47302
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86003
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35498
NFF	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.43067
superficial stratum of r3BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06347
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.95462
PMC10830421-41589_2023_1452_MOESM5_ESM.xlsx-HEK293T_MAX-Tg_tissues-Unnamed_0_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.957768
7509_RPS19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.802757
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.506399
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNF38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40462
NDUFA13	Pathway Commons Protein-Protein Interactions	1.0	null
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7469_RPL38_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24118
KMS-12-BM	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.74423
lateral hypothalamic area, mammillary region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.849024
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
ERAL1	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MV-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1435	CCLE Cell Line Gene Expression Profiles	-1.0	-2.07086
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881833
NFE2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6ES-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EGR1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.732497
LRRC10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15822
cellular component organization	GO Biological Process Annotations 2015	1.0	null
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.868777
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9528
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.691
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0008
RCOR1	ENCODE Transcription Factor Targets	1.0	null
foxa2_20483781_p15_lung_lof_mouse_gpl1261_gse19204	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.903258
r6 part of ventral parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82088
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GATA1	ENCODE Transcription Factor Targets	1.0	null
RPMI2650	DepMap CRISPR Gene Dependency	1.0	2.0514
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.51882
Perturb_13827_KO_Pten_SRP302970	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.49143
GSE150557_1_v_0_dnmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ECI1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-V955-0326-SM-4JBGV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.914584
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.88439
ARID3A	ENCODE Transcription Factor Targets	1.0	null
Perturb_10058_KD_UCHL5_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.86698
SIN3A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86915
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
brownfat	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.987149
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MRPS18A	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JJ-01A-21R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04265
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01959
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.843458
layer III of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.99956
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68248
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUO-01A-12R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4499_LAMB1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.582474
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
salivarygland_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.28089
H3K56ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSTO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02546
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
7561_RRP12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.653738
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16814
JARID1A-20064375-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-O5YT-1426-SM-3MJHC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873453
KYM1_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	2.007
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48191
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
Leber hereditary optic neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
10040_ZCCHC9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.586513
Perturb_14482_KO_Lhx8_SRP228490	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.37855
basomedial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.922417
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1953
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.7447
CREB1-23762244-HIPPOCAMPUS-RAT	ChEA Transcription Factor Targets 2022	1.0	null
10702_ZNHIT6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500094
ZNF680	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4757
Perturb_10959_KO_Aplnr_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.55295
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WYVS-0526-SM-3NM9W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933592
GTEX-XUW1-1726-SM-4BOOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02742
macromolecular complex disassembly	GO Biological Process Annotations 2015	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
gallbladder	HPA Tissue Protein Expression Profiles	1.0	0.932281
Perturb_12036_KD_Prmt6_SRP131294	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.0906
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.414
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r6 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48964
7479_RPL7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.513333
RBMX	Pathway Commons Protein-Protein Interactions	1.0	null
GSE193258,GSE193259_5_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.307628
mantle zone of r4Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10282
hippocampus (hippocampal formation)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.3795
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POSTN_01_293	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60645
r3 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37054
r3 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42721
MRPL24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15652
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.990848
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.38546
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NDUFS2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.035
GSE224969,GSE224971_0_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XMD1-0526-SM-4AT4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849285
AE-18-ZM98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273139
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13867_KD_KDM6B_SRP258989	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.57373
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31389
NDUFAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63265
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68672
Perturb_13834_KD_RYK_SRP131789	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.8658
POLR2A_K562_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4680_KO_Psip1_SRP153901	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.30879
H3K79me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHEK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11958
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NFATC1	ENCODE Transcription Factor Targets	1.0	null
Adenoma_Adrenal gland_GSE8514	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.68716
sirolimus_homo sapiens_gpl6244_gse15703	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE114258_1_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.13895
GTEX-U8XE-0926-SM-3DB8V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0125
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.404
BL1706 (PHB2)	NURSA Protein Complexes	1.0	null
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15482
H3K9ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00026
mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.588397
ETS1	ENCODE Transcription Factor Targets	1.0	null
5659_NGDN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.674147
DBT	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.67403
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02051
Liver hepatocellular carcinoma_LIHC_TCGA-T1-A6J8-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.54858
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57883
H3K4me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_15793_KD_Nrl_SRP380201	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.67495
3286_GART_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.59253
7506_RPS17_ENST00000330339.7	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.522492
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39279
globose nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07426
CHD1	ENCODE Transcription Factor Targets	1.0	null
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-10_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
diethylstilbestrol_mus musculus_gpl6887_gse37969	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CACNG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27398
ChIP_ZFP42_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8569982-41065_2021_205_MOESM1_ESM.xlsx-mono_THP1_a2b_tpm1-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
r4 part of vestibular sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10282
NR2F2	ENCODE Transcription Factor Targets	1.0	null
LN229_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	2.93102
MRPL21	Pathway Commons Protein-Protein Interactions	1.0	null
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46933
GTEX-OIZH-0326-SM-2HMKC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846014
GSE215351,GSE215794_4_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7443_RPL18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.745615
Bladder Urothelial Carcinoma_BLCA_TCGA-PQ-A6FN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZSCAN18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56373
Sarcoma_SARC_TCGA-IW-A3M5-01A-22R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18133
IGF2BP1	Pathway Commons Protein-Protein Interactions	1.0	null
ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.668422
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837153
POP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NL3H-0008-SM-4E3HU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08219
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18636
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9853
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37135
HSPD1	Pathway Commons Protein-Protein Interactions	1.0	null
r6 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.74076
MRPL22	Pathway Commons Protein-Protein Interactions	1.0	null
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09934
outer CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24569
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.39092
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_down_VENN-1175_elements_included_exclusively_in_HIF1_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
organelle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.060414
MET_knockout_251_GDS3148	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.4782
TFAM	Pathway Commons Protein-Protein Interactions	1.0	null
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.3029
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OB glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07843
ZFP42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19944
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7540_RPSA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.503449
AR-21909140-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47559
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.45087
posteroventral (inferior) parietal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.61329
PLXNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26878
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-JV-A5VF-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COX11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05437
mitochondrial part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.114696
4472_KRR1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.545573
Sporangiospore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.872
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPL39	Pathway Commons Protein-Protein Interactions	1.0	null
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K14ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.641204
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1734	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3258
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.047304
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PAQR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35529
GSE237040_4_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41674
LMX1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.729
Lateral vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52272
mantle zone of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.11365
HCC1569	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ebf2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.3605
Urinary Bladder Neoplasms	CTD Gene-Disease Associations	1.0	1.04276
mantle zone of AHy	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.04556
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.931893
WBSCR16	Pathway Commons Protein-Protein Interactions	1.0	null
9682_UTP15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.829264
496100618_PCx_probable Alzheimer's disease_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.39502
MYC	ENCODE Transcription Factor Targets	1.0	null
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.287191
Small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.682
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIX5_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PSDG-1126-SM-2S1ON	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853771
large intestine cancer	GWASdb SNP-Disease Associations	1.0	0.440539
SETDB1	ENCODE Transcription Factor Targets	1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.635954
ALEXANDERCELLS	CCLE Cell Line Gene CNV Profiles	-1.0	-2.50797
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF382	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.2963
FLI1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ABHD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88473
medial mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.56647
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.580689
mantle zone of r2Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14528
ATP5F1	Pathway Commons Protein-Protein Interactions	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45U-01A-12R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135244_0_v_1_trdmt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
7444_RPL19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.589834
Dang	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.584
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETFA	Pathway Commons Protein-Protein Interactions	1.0	null
bed nucleus of the stria terminalis, mediocentral division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29996
496100644_HIP_probable Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.17836
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.3084
HB1119	DepMap CRISPR Gene Dependency	1.0	2.07402
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.89579
UQCRFS1	Pathway Commons Protein-Protein Interactions	1.0	null
mantle zone of r3Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15742
Necrosis	CTD Gene-Disease Associations	1.0	1.41008
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, trunk, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39659
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10954_KO_Acot4_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.0154
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.314
TGFBR2_knockout_292_GSE46150	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.05664
9909_XRCC6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08482
RTN4IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63977
Perturb_11041_KO_Tmem106b_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.25388
H3K36me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCL3	ENCODE Transcription Factor Targets	1.0	null
18535662-TableS2d	GeneSigDB Published Gene Signatures	1.0	null
TIMM21	Pathway Commons Protein-Protein Interactions	1.0	null
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4423
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GABPA	ENCODE Transcription Factor Targets	1.0	null
OPM2	CCLE Cell Line Gene Expression Profiles	-1.0	-2.10988
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A852-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COR-L23	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.85698
ATP5L	Pathway Commons Protein-Protein Interactions	1.0	null
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.34067
7510_RPS20_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.619449
MAX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02474
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PRDX4	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.40921
GTEX-Q2AI-1226-SM-48U14	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88369
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
PMC8423434-mmc7.xlsx-SOX2_Primed-Genes_n_3042_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
ALDH2	Pathway Commons Protein-Protein Interactions	1.0	null
7537_RPS7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.865612
PMC8173714-NIHMS1678410-supplement-Supplementary_Table_2.xls-OfficialIPEXsig-Supplementary_Table_2_-_IPEX_signature_genes_with_their_average_IPEX_HD_fold_change_in_Tregs_and_Tconvs_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_5104_KO_Ythdc1/Dux_SRP251747	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.81487
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_17583_KO_Bap1_ERP016523	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.46924
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HOXA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.8612
Kidney Chromophobe_KICH_TCGA-KM-8439-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-KDM5B-Unnamed_6_KDM5B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.36686
H2BK12ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55G-2326-SM-2TC61	GTEx Tissue Sample Gene Expression Profiles	1.0	2.28509
H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8049
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.05257
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
4780_MAK16_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.599448
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.95573
NOP58	Pathway Commons Protein-Protein Interactions	1.0	null
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
HMEL	CCLE Cell Line Gene Expression Profiles	-1.0	-2.29763
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.228221
plasma membrane	LOCATE Curated Protein Localization Annotations	1.0	null
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65D-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymph	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-VUSG-0926-SM-3GIK6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914667
Perturb_1811_KO_Nr1h2/Nr1h3_SRP158140	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.74474
GABP-17652178-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE157383_3_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RUSQ-0526-SM-2TF72	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84282
YY1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242083,GSE242098_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE130956_0_v_3_icaritin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
8405_SRFBP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.657497
H3K4me1_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.059502
Perturb_16938_OE_Prkag1_SRP162537	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.08488
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7857
intermediate stratum of r3Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.01314
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7628
LCN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14288
TAL1	ENCODE Transcription Factor Targets	1.0	null
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.1589
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16141321-Table2	GeneSigDB Published Gene Signatures	1.0	null
3042_FCF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.739457
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
accumbens nucleus, core domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40054
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17796
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HT-1197	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EWS-FLI1-20517297-SK-N-MC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
KARPAS-422	COSMIC Cell Line Gene Mutation Profiles	1.0	null
leber hereditary optic neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.32017
ETS1-20019798-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MYC	ChEA Transcription Factor Targets	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
GTEX-X4EP-0011-R2B-SM-3P625	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1812
ATP5C1	Pathway Commons Protein-Protein Interactions	1.0	null
OB olfactory fiber layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34314
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8348
GTEX-SIU7-0526-SM-3NM8I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853259
GSE167218_1_v_0_hoxd12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.700981
KYSE-180	COSMIC Cell Line Gene CNV Profiles	1.0	2.26395
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-RB-A7B8-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE98579_0_v_1_tfam_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
Perturb_13218_KO_Dres1_SRP127601	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.42896
Mitochondrial inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
MBD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11473
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HMCB	CCLE Cell Line Gene Expression Profiles	1.0	1.37966
cellular protein complex disassembly	GO Biological Process Annotations 2015	1.0	null
abnormality of head or neck	GWASdb SNP-Phenotype Associations	1.0	0.136187
NDUFA9	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01791
Perturb_17439_KO_Uqcrfs1_SRP279621	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.81649
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5931-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Perturb_7084_KO_Perk_SRP309948	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.00835
7525_RPS3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.832309
SUDHL10	DepMap CRISPR Gene Dependency	1.0	2.08371
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7430-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEx AdiposeTissue 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	-1.0	-6.22418
ANKRD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02907
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.744896
hsa-miR-596	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979845
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52866
FOXM1	ENCODE Transcription Factor Targets	1.0	null
Pallidum, caudal region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09238
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GLUD1	Pathway Commons Protein-Protein Interactions	1.0	null
Large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.207
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28392
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34004
duodenum	HPA Tissue Protein Expression Profiles	1.0	0.932281
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.76543
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.973228
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FASTKD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67841
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
1301_CCDC86_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.733926
MIR221_KD_GDS4054_455_human_MCF7 breast cancer cells (fulvestrant-resistant)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
medial superior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02769
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1475
HCC1599	CCLE Cell Line Gene Expression Profiles	1.0	1.6194
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7665_KO_SNORD45C_SRP257547	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.07687
Integrin alpha11-beta1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.502
GTEX-R3RS-0008-SM-48FF1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950815
GTEx Heart 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-3.8179
r9 part of the lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34713
Mitochondrial translation elongation	Reactome Pathways 2024	1.0	null
4472_KRR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.734414
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZH-0326-SM-3DB7A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925372
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.45082
MRPL1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VX-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NFYA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19301
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.772335
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.4607
YBX3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
3677_HEATR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.914899
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10953
BGC823	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44992
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41129
neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.319363
SLC25A13	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00779
AIFM1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.03832
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.06442
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_11018_KO_Prkab1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.45927
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.867649
Kidney Chromophobe_KICH_TCGA-KM-8476-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8593586-mmc2.xlsx-LIN28A_interactome-Unnamed_1_LIN28A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE235945_1_v_0_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lymphnode_5a	HPA Tissue Sample Gene Expression Profiles	1.0	0.998854
Perturb_244_KO_Clic4_SRP318761	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.84051
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.586572
VENTX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27977
CREB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830909
Perturb_17260_KO_Gja1_SRP247546	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	15.9875
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Organelle biogenesis and maintenance	Reactome Pathways 2014	1.0	null
PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4114-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TOP1	Pathway Commons Protein-Protein Interactions	1.0	null
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-2.0152
EW-13	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.32444
Lung adenocarcinoma_LUAD_TCGA-50-6595-01A-12R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ALDH1L2	Pathway Commons Protein-Protein Interactions	1.0	null
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
GSE160304,GSE163392_0_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6886551__F4	PFOCR Pathway Figure Associations 2024	1.0	null
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.625973
periventricular stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54929
CEBPB	JASPAR Predicted Transcription Factor Targets	1.0	null
MYBL2	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2861-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6493_PNO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.763449
ChIP_PHC1_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-1.20013
5192_MRM1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500852
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37135
superficial stratum of r1BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61228
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.82497
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08331
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.878016
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.31935
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.074701
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7VF-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PHC1-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
r6 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22134
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.883628
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-103b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
inner CP in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.44669
M14	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QEG4-0526-SM-48TZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934862
Perturb_16712_KO_Ppbp_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.05671
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	1.0	3.18151
GTEX-P4QR-0008-SM-48TE2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848642
RERF-LC-MS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE138863_3_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
AB-37-JM16_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.489298
DLG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19409
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_6520_KD_HES3_SRP162877	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.12651
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08028
NOP2	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_10965_KO_Blk_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.94174
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.781012
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86855
HOMER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24034
H3K4me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WFON-0226-SM-3GIKR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916815
GATA2	ENCODE Transcription Factor Targets	1.0	null
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
CD105+_Endothelial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.920837
membrane	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7058_KO_Sod2/Ogg1_ERP107154	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.8592
GSE182680,GSE182683_7_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SOX2	ChEA Transcription Factor Targets	1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF326	Pathway Commons Protein-Protein Interactions	1.0	null
Mesothelioma_MESO_TCGA-MQ-A6BN-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2357
HS 255.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.961524
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01957
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47308
15735024-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.958705
Perturb_16359_OE_Ppargc1a_SRP278337	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	16.63
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844448
GTEX-OHPM-0126-SM-2YUN9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919017
RPUSD3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
r4 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16543
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WY7C-0526-SM-3NB3D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24801
Perturb_3375_KO_Mir31_SRP106571	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.48523
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SPRY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25661
7461_RPL34_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.925798
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.92472
7475_RPL5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.732376
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21087
NDUFS1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE234289_3_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FAAP100	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17122
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7406_KD_HNRNPH1_SRP010280	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.12676
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09873
Perturb_7240_KO_CDK8/CDK19_SRP271652	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S33H-1226-SM-4AD69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00135
AR-21909140-LNCAP PROSTATE CANCER CELL LINES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07748
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_56_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-4.34169
Lung squamous cell carcinoma_LUSC_TCGA-52-7810-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51G-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Infralimbic area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08035
KNS-62	COSMIC Cell Line Gene CNV Profiles	1.0	2.26395
translational termination	GO Biological Process Annotations 2015	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.47226
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Metabolism of proteins	Reactome Pathways 2024	1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54945
superficial stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89768
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.82847
H4K8ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
kidney	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.872103
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrial inner membrane	GO Cellular Component Annotations 2023	1.0	null
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14341
5909_NVL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.703796
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.81436
Mitochondrial large ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36873
neoplasm of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.293661
GTEX-VUSG-1526-SM-4KKZH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861228
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.926625
T24_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	7.60758
GTEX-XXEK-1226-SM-4BRUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06755
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18123
MRPS9	Pathway Commons Protein-Protein Interactions	1.0	null
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331952
7450_RPL23_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24236
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_1683_KO_Nox4_SRP356837	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.39852
SNU626	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48321
Muscular Dystrophy_Muscle - Striated (Skeletal) - Diaphragm (MMHCC)_GSE3252	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.68562
STOML2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MRPL17	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.968733
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PW2O-1426-SM-48TCD	GTEx Tissue Sample Gene Expression Profiles	1.0	3.19148
stomach	HPA Tissue Protein Expression Profiles	1.0	0.932281
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9219
structural constituent of ribosome	GO Molecular Function Annotations 2015	1.0	null
Perturb_10731_KO_Nr1h4_SRP299252	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.43923
organelle outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.451631
9804_WDR12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.538347
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0254
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36804
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A6EC-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TT	CCLE Cell Line Gene CNV Profiles	1.0	1.40518
MYC_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5Q6-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.692691
DA-85-SU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200036
IA-65-QX27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.237014
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.82336
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.924432
9366_TSR2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.749145
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.7044
DHRS4L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09508
mantle zone of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32422
MYCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00298
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870417
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
2545_EIF3B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.68802
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4470_KRI1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.804587
9364_TSR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.570625
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RERF-LC-MS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03742
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61G-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRPS24	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4257	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18362
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324765
SHMT2	Pathway Commons Protein-Protein Interactions	1.0	null
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331744
GSE139966_1_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880411
ACOT9	Pathway Commons Protein-Protein Interactions	1.0	null
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.414731
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3096
NU-DUL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.31639
Inferior salivatory nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31667
HCFC1	ChEA Transcription Factor Targets	1.0	null
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AR	ChEA Transcription Factor Targets	1.0	null
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881626
Perturb_3540_KO_ZNF410_SRP304786	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.55213
cranial nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.776159
GTEX-X8HC-0626-SM-4E3HQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868102
GSE182680,GSE182683_10_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SUCS-1426-SM-4DM5W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04001
Perturb_2148_OE_RKIP_SRP189735	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.63538
GSE182680,GSE182683_10_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.968319
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.873108
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2814	CCLE Cell Line Gene CNV Profiles	1.0	2.63453
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00674
CL-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.966387
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.9322
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TYK-NU.CP-R	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.936191
GTEX-POYW-1326-SM-48TCG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06289
5910_NXF1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.557728
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.048457
GTEX-U8XE-0126-SM-4E3I3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54168
testis_4a	HPA Tissue Sample Gene Expression Profiles	1.0	0.943059
GTEX-T5JW-1326-SM-4DM5G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878641
dorsal lateral geniculate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26159
RCOR1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTPBP10	Pathway Commons Protein-Protein Interactions	1.0	null
Insulin Resistance	CTD Gene-Disease Associations	1.0	1.1198
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FB-66-UU47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.530665
MEF2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.3053
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE155567_1_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952882
Perturb_2696_KO_SET1B_SRP089784	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.97197
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830909
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.515
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HGC27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48321
Perturb_10922_KO_Ly6e_SRP250973	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.87941
VAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.128
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.1414
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220337
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.844386
TE6	CCLE Cell Line Gene CNV Profiles	1.0	1.69247
u698	HPA Cell Line Gene Expression Profiles	1.0	0.890056
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HB-24-GP45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.483662
liminal part of the r6 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64403
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24949
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169571_0_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Medial amygdalar nucleus, posterodorsal part, sublayer c	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66567
CA-48-SW47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336799
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21612
AARS2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE143512,GSE143513_0_v_1_nr4a3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GATA1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51414
Brain Lower Grade Glioma_LGG_TCGA-HT-A5RA-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.94177
GTEX-U3ZN-1426-SM-3DB87	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09754
NFE2	ENCODE Transcription Factor Targets	1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07808
PMC9904760-elife-79363-supp2.xlsx-MDS1-Gene_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
SIX5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6871-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ERLIN2	Pathway Commons Protein-Protein Interactions	1.0	null
intermediate stratum of r6Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34821
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_8594_KO_Tsc1_SRP300523	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.75684
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SALL4-22934838-CD34+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9013128-NIHMS1795992-supplement-6.xlsx-ARID2_MUT_Upregulated-Gene_name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
2114_DDX27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01016
estradiol_homo sapiens_gpl570_gse5102	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PANC 03.27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42971
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r1 part of vestibular nucleus Y	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10115
KLF4-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.613366
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62882
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
NDUFV1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.919983
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51249
GTEX-OOBK-0008-SM-3NB27	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15129
MCF12A	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.561467
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r5 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07686
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r4Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06424
MRPS2	Pathway Commons Protein-Protein Interactions	1.0	null
intermediate stratum of r6Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81922
GTEX-OIZG-0008-SM-4E3J2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16922
Perturb_2367_KO_CGAS_ERP131756	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.06301
SLC25A10	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hmc1	HPA Cell Line Gene Expression Profiles	-1.0	-0.89278
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965227
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LF-94-HB11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22874
16_AATF_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.584792
MRPS5	Pathway Commons Protein-Protein Interactions	1.0	null
2546_EIF3CL_ENST00000380876.4,ENST00000398943.3,ENST00000398944.3	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.712521
MRPL3	Pathway Commons Protein-Protein Interactions	1.0	null
periventricular stratum of Pal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37022
mainolfactoryepithelium.MOE.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.3273
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8ZZ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FAM120A	Pathway Commons Protein-Protein Interactions	1.0	null
cochlear nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.43444
7505_RPS16_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00203
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18992
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.767255
PDCD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47436
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12318_KD_NRDE2_SRP161520	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.24269
GSE181003_3_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
GSE98898_7_v_2_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.545325
SUDHL5	DepMap CRISPR Gene Dependency	1.0	2.05053
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_17475_KO_Ubr4_SRP259313	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.70229
NFIC	ENCODE Transcription Factor Targets	1.0	null
GSE133070_2_v_4_prss1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16164
GTEX-POYW-0526-SM-2XCEY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76098
Perturb_10879_Mut_Nlrp3_SRP230804	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.34963
GTEX-QV44-0926-SM-2S1RH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913555
GTEX-XMD1-2826-SM-4AT5F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847699
GSE186287_2_v_0_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MRPL20	Pathway Commons Protein-Protein Interactions	1.0	null
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.882371
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HLF_LIVER	CCLE Cell Line Proteomics	1.0	2.24708
GSE62843,GSE64371_2_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
central nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.22769
THAP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of r2Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23178
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.933479
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22127
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10153265-media-3.xlsx-BENPORATH_SOX2_TARGETS_v2023_1-STANDARD_NAME_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K79me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_1067_KD_PHF19_SRP188592	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.50135
7426_RPF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.69374
Orbital area, lateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14373
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39Y-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE153871_0_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5175-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GE-34-TW62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.38732
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.805764
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193685_2_v_3_il11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LNCaP cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.25068
PMC12311696-ao5c02807_si_001.pdf-88-ZNF598_ZNF598	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
7431_RPL10A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.552521
Perturb_5869_KD_Cpsf7_SRP336206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.57901
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC95	CCLE Cell Line Gene CNV Profiles	1.0	1.89582
single-organism biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MP-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRPL27	Pathway Commons Protein-Protein Interactions	1.0	null
DB	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77595
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.932408
superficial stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2913
PTCD3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U8T8-1126-SM-4DXUE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.50461
heart	GTEx Tissue Gene Expression Profiles	1.0	1.28491
NCI-H2172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59247
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5447
CAL51	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.961524
Perturb_17_OE_Carhsp1_SRP217699	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.62234
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_11012_KO_Phtf1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.20976
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
inner CP in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.940132
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6338-01A-12R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.27778
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01689
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14147
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.35152
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42028
PUS1	Pathway Commons Protein-Protein Interactions	1.0	null
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
rectum	HPA Tissue Protein Expression Profiles	1.0	0.932281
Bed nuclei of the stria terminalis, anterior division, anterolateral area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18165
SP in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.875267
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.98252
SSB	Pathway Commons Protein-Protein Interactions	1.0	null
AC-30-XU83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247919
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930746
MCU	Pathway Commons Protein-Protein Interactions	1.0	null
TE10	CCLE Cell Line Gene CNV Profiles	1.0	2.09331
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2
CREB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
786O_KIDNEY	CCLE Cell Line Proteomics	1.0	8.40879
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.71976
Perturb_4826_KD_Nfya_SRP149362	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.82633
PMC4335056-pone.0116726.s005.xlsx-X-ChIP_NOT_TX100_QE-GENE_Official_symbol_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-7269-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1755	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33114
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.053375
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76041
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
AP2M1	Pathway Commons Protein-Protein Interactions	1.0	null
2113_DDX24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.752725
EZH2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1172
4108_IMP4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.59359
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.5181
RFX5	ENCODE Transcription Factor Targets	1.0	null
MUT	Pathway Commons Protein-Protein Interactions	1.0	null
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.857692
PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
TEFM	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9643473-Table1.xls-MAF_0_005-Gene_refGenecanonical_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32885
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OSGEP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1375
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9037
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
ME2	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26293
Lateral reticular nucleus, magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22134
Bed nuclei of the stria terminalis, anterior division, rhomboid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06304
SNU-423 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.099
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of r5Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07686
Perturb_6735_KD_EHMT2_SRP043290	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.9924
RNF215	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15151
Lung adenocarcinoma_LUAD_TCGA-38-4631-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7713_SDAD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.538311
ATF2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrial large ribosomal subunit	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72841
GATA3-21867929-TH1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
superficial stratum of r3Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38985
Cochlear nucleus, subpedunclular granular region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23178
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-1126-SM-3GAEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828195
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13327
BCL3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRAK2_knockout_76_GSE24264	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.43544
Spear	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.51
PYCR2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE111247_2_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
fastigial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1417
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.413239
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-3.55206
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09236
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52044
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.291573
r4 part of basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06038
DOV13	CCLE Cell Line Gene CNV Profiles	-1.0	-1.78712
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.887017
IGF1R_druginhibition_47_GSE14024	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.55234
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AN-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LOUCY	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.98177
Perturb_18122_KO_Bmal1_SRP068418	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.43512
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the lung	GWASdb SNP-Phenotype Associations	1.0	0.146755
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04862
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.826793
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210101,GSE210114_0_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25958
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IK-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular component organization or biogenesis	GO Biological Process Annotations 2015	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.56693
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
20068109-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
b220.bcell	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.856115
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9614
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7480058-95058-2020.08.29.20182899-10.xlsx-1ModuleKeyDrivers-Target_gene_symbol_that_KD_acts_upon_AR	Rummagene Transcription Factor Associations 2026	1.0	null
2225_UTP25_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.629541
lymph	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
7433_RPL11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.665705
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43415
temporal pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.833424
TAF7	ENCODE Transcription Factor Targets	1.0	null
NCCIT	COSMIC Cell Line Gene CNV Profiles	1.0	2.26395
SOX17-20123909-XEN-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
head and neck cancer	GWASdb SNP-Disease Associations	1.0	0.683009
Anterior olfactory nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.35501
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34844
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67303
NANOG-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232571
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.810356
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7094
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20802
Lung squamous cell carcinoma_LUSC_TCGA-77-8148-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BXPC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10714
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.862567
caco2	HPA Cell Line Gene Expression Profiles	1.0	1.23028
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830909
GSE148657_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_18007_Mut_Card14_SRP260070	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.64019
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K9ac_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SMAD1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15716
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tbx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.6525
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.1571
roof plate of p2 (epithalamic roofplate)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05612
5089_NIFK_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.903361
mitochondrial nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.214714
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.674893
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MRPL41	Pathway Commons Protein-Protein Interactions	1.0	null
NFIC_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78168
GSE199899_3_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4696-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5089_KO_Sall4/Sall1_ERP014607	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.5065
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
Cco	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.931
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15366
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.884975
Lung adenocarcinoma_LUAD_TCGA-64-5781-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01791
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.21402
NANOG-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
6605_PPAN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.534075
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
protein-containing complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
mitochondrial translational elongation	GO Biological Process Annotations 2015	1.0	null
r2 part of superior vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24063
parabigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0527
BEN	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51313
Perturb_16405_OE_Ppargc1a_SRP173477	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.4193
r5 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08738
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31389
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.939
TCF12	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TCF7L2-21901280-H4IIE-RAT	ChEA Transcription Factor Targets 2022	1.0	null
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09058
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XMK1-1326-SM-4B65Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824847
NDUFAF3	Pathway Commons Protein-Protein Interactions	1.0	null
2127_DDX51_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.705561
GSE121866_0_v_2_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ELK1	ENCODE Transcription Factor Targets	1.0	null
Organellar large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.715
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.428679
Lung squamous cell carcinoma_LUSC_TCGA-21-1075-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.797622
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
2132_DDX56_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.07049
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4293
HOXB7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9249
PTCD1	Pathway Commons Protein-Protein Interactions	1.0	null
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00435
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LC-1-SQ	COSMIC Cell Line Gene CNV Profiles	1.0	2.26395
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959932
YY1	ENCODE Transcription Factor Targets	1.0	null
Perturb_9563_KO_Ogt_SRP110508	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.87764
TEAD4_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03359
MBD4_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.57822
NCIH82	CCLE Cell Line Gene Expression Profiles	1.0	1.45436
RSL1D1	Pathway Commons Protein-Protein Interactions	1.0	null
2105_DDX18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00478
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_74_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SMAD1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
OSC-20	COSMIC Cell Line Gene CNV Profiles	1.0	2.26395
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC1171	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59741
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPN-2726-SM-2I5H4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22265
superior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07908
EWSR1	ChEA Transcription Factor Targets	1.0	null
MMAB	Pathway Commons Protein-Protein Interactions	1.0	null
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OXRK-0126-SM-3NB1E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853707
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A263-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-7521-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9482_UBA52_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11076
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16084_KO_Nfya_SRP270915	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.42586
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906856
Acute Myeloid Leukemia_LAML_TCGA-AB-2819-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
motor nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.972104
primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17787
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046094
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.373774
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04504
MRM1	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6362-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Colitis	CTD Gene-Disease Associations	1.0	1.03419
AB-18-YN11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236545
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial translation termination	Reactome Pathways 2024	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.091
CHP-134	COSMIC Cell Line Gene Mutation Profiles	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_2day-MOI-10^4_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.92263
Perturb_2600_KD_HDAC2_SRP149375	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.87234
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2325_KD_SF3A1_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.83306
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11121
testis_7e	HPA Tissue Sample Gene Expression Profiles	1.0	1.19934
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE205729,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r3 part of magnocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7126
MIAPACA2_PANCREAS	CCLE Cell Line Proteomics	1.0	3.21071
Organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6442
7505_RPS16_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.542485
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01344
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
PMC10120406-JEM_20220962_DataS2.xlsx-Elf1_target-Data_S2_List_of_Elf1-target_genes_2_d_after_LPS_pIpC_stimulation_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.909201
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KYSE140	CCLE Cell Line Gene Expression Profiles	1.0	1.62922
17660535-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
TEAD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
neoplasm of the lung	GWASdb SNP-Phenotype Associations	1.0	0.585136
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.0993
MYC-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE135352_6_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.36022
GSE112860_5_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.975134
PMC5303304-13073_2017_407_MOESM5_ESM.xlsx-mycn-sy5y-se_single_24DMSO_vs_4-Table_S4_Genes_differentially_expressed_by_48h_Dox_MYCN_overexpression_treatment_DE_comparison_with_SY5Y-MYCN_control_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24899
ribonucleoprotein complex	GO Cellular Component Annotations 2015	1.0	null
GSE154577_6_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.67574
MRPL24	Pathway Commons Protein-Protein Interactions	1.0	null
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JUN_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPM1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29837
7508_RPS19BP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.643161
GSE158320,GSE183351_0_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-FC-A6HD-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_13958_KO_YAP1_SRP194022	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.79298
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64114
CILP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10464
GTEX-TSE9-0726-SM-3DB8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08425
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.12268
SIX5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I5-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_10973_KO_Cxcl17_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.18231
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.75044
ESRRB	JASPAR Predicted Transcription Factor Targets	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC5263239-mmc2.xls-SEM_wt_MLL-Gene_name_1614_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147943_7_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JHH6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6182
HNRNPAB	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
2526_EIF1AD_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.569705
Perturb_17415_OE_Gata3_SRP150425	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.00678
GSE180185_9_v_8_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92337
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.772302
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	1.0	3.23452
PHB2	Pathway Commons Protein-Protein Interactions	1.0	null
salivary gland	HPA Tissue Protein Expression Profiles	1.0	0.932281
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.28632
Perturb_5042_Mut_Adnp_SRP313259	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.93484
7522_RPS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.59568
Smooth septate junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.197
Perturb_4567_KD_Smc1a_SRP172038	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.76962
Perturb_5225_KO_Mettl3_SRP184527	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.7657
MBD4	ENCODE Transcription Factor Targets	1.0	null
MTA3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.879039
GSE186810,GSE186813_7_v_0_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47495
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spinal nucleus of the trigeminal, oral part, middle dorsomedial part, dorsal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1383
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8744
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21039
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.7095
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CIITA-18437201-RAJI-B-AND-IDC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2098
H3K27ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XOT4-1426-SM-4B65T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01733
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.791493
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043698
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5702_NLE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.619776
6605_PPAN_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.751412
Large ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.902603
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825649
myopathy, lactic acidosis, and sideroblastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
GSE255432_7_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.48268
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08088
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24799
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.77364
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858139
ABCF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1346
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.48621
GSE190316,GSE190324_0_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73359
MCAT	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5117-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE147662_3_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KC-11A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4713_LTV1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.587772
yy2_20215434_hela_lof_human_gpl570_gds3788	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.094165
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.593965
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044963
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25371
Primary leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.997
IZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.826158
C1QBP	Pathway Commons Protein-Protein Interactions	1.0	null
GSE153871_0_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28065
dorsolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.966987
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.28247
TK	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.87399
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.335631
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gata4_16914500_e9dot5_atrioventricular_canal_lof_mouse_gpl1261_gds3663	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.027784
TFAP2C	ChEA Transcription Factor Targets	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052257
CREB1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5B-21448134-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
4604_LLGL2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51792
6219_PES1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.79481
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.9895
H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2J2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23669
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.67813
GTEX-O5YT-2126-SM-3MJGD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35513
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_8405_KO_Tcf4_SRP318203	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.38258
GSE95685_2_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
trochlear nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28323
Ribosomal protein L47, mitochondrial	InterPro Predicted Protein Domain Annotations	1.0	null
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.892126
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
paclitaxel_homo sapiens_gpl570_gse19136	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAFK_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-0326-SM-32PKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35597
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4PQ-1026-SM-3NMCN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17675
EGR1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0576
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.9778
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1137
adrenal gland	GTEx Tissue Gene Expression Profiles	1.0	1.58384
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3849
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC25A1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K79me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.923807
FLI1	ENCODE Transcription Factor Targets	1.0	null
paraseptal subpallium	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08932
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.894414
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855325
Perturb_16628_KD_Sod1_SRP217736	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.62352
Dyskinetic cerebral palsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
2456_EBNA1BP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.615595
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.597116
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.44638
K562_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173414
anterior olfactory area, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31859
GSE239578_0_v_6_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLF4	ChEA Transcription Factor Targets	1.0	null
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.38546
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.06972
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A7-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ALL-SIL	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.76528
cancer	GWASdb SNP-Disease Associations	1.0	0.112072
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.15455
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21144
NCI-H520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13893
GSE102505_5_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.6685
Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MECOM	ChEA Transcription Factor Targets	1.0	null
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933389
PPARG	JASPAR Predicted Transcription Factor Targets	1.0	null
Microsporidiosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.512
posteroventral (inferior) parietal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20935
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
capan2	HPA Cell Line Gene Expression Profiles	-1.0	-1.05133
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17442_OE|Mut_Tal1|Akt_SRP366791	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.31768
GSE196343_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.715652
Perturb_11076_KO_Cnot1_ERP110668	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.32282
Septofimbrial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05386
hsa-miR-548ae	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.752969
anterior pretectal nucleus, ventral superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2913
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE125403_7_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
RRP12	Pathway Commons Protein-Protein Interactions	1.0	null
SA-32-CC58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.452633
7445_RPL21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.927166
Medial amygdalar nucleus, posterodorsal part, sublayer b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70247
Nr1h3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.2501
MRPL46	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8D-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_WT_3T3_ONLY_1626_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131649_4_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intestinal cancer	GWASdb SNP-Disease Associations	1.0	0.440539
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3451-01A-02R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.03654
VZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.74366
LN215	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66762
Hyperplasia	CTD Gene-Disease Associations	1.0	1.23899
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HNRNPF	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8046-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Gene_Name_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_266_KO_ADIRFAS786_SRP366780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.35156
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8894
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03147
PARS2	Pathway Commons Protein-Protein Interactions	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
L-428	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.31786
UVSSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01069
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9151_KD_DDX21_SRP327839	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.42039
gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.394042
neoplasm of head and neck	GWASdb SNP-Phenotype Associations	1.0	0.585136
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
VINCRISTINE	DGIdb Drug Targets 2026	1.0	1.04816
GTEX-T8EM-0826-SM-4DM76	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932947
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.228221
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16699_KO_Apom_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.53818
GFUS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33448
GSE148695,GSE167281_0_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111138,GSE111149_1_v_0_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TCFAP2C-20176728-TROPHOBLAST-STEM-CELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
AGK	Pathway Commons Protein-Protein Interactions	1.0	null
TF1	CCLE Cell Line Gene Expression Profiles	1.0	1.67406
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MM.1S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10908
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.977017
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274157
Lung adenocarcinoma_LUAD_TCGA-73-7499-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PAX5_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-5337-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU1214	CCLE Cell Line Gene CNV Profiles	1.0	1.5499
DDX28	Pathway Commons Protein-Protein Interactions	1.0	null
ACTA2	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.41698
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01394
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-1_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
17023574-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-U4B1-0726-SM-4DXUA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894001
Perturb_15833_KO_Abca4_SRP050429	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.35526
SLC25A4	Pathway Commons Protein-Protein Interactions	1.0	null
ChIP_YY1_21170310	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09666
Acute Myeloid Leukemia_LAML_TCGA-AB-2885-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
19190339-Table1b	GeneSigDB Published Gene Signatures	1.0	null
ranolazine_mus musculus_gpl1261_gse25767	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K18ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MRPL50	Pathway Commons Protein-Protein Interactions	1.0	null
superficial stratum of r6Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46085
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Perturb_4390_KO_AMBRA1_SRP251921	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.88649
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0722
GTEX-P4QS-2126-SM-3NMCF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61639
Perturb_14370_KD_IGF2BP1_SRP131243	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.72888
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.832433
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91947
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TALL1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76114
intermediate stratum of r5Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.09668
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4446_KD_Fbl_DRP007972	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.83582
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-S32W-0626-SM-2XCBG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975265
dorsal peduncular cortex, intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29467
H3K27ac_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FLI1	ChEA Transcription Factor Targets	1.0	null
KDM5B-21448134-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-W5WG-1126-SM-4LMK4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987658
OB-06-WW76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225844
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.953739
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37407
Perturb_13957_KO_YAP1_SRP194022	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.32029
hippocampus	HPA Tissue Protein Expression Profiles	-1.0	-1.65543
Olfactory glomerulus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.643
7466_RPL36_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.25951
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1495
GTEX-P4QS-0326-SM-2I3EU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02383
MRPL10	Pathway Commons Protein-Protein Interactions	1.0	null
ovary	GTEx Tissue Gene Expression Profiles	-1.0	-0.941875
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.577626
GSE195514_0_v_1_stk25_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.02797
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970365
697	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.88774
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
ICT1	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH650	CCLE Cell Line Gene Expression Profiles	-1.0	-1.99566
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7540_RPSA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519804
medial amygdala, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.92014
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.922648
16760443-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
NCI-H2228	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.29271
accumbens nucleus, shell domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28411
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
2580_EIF6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.772004
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.62526
H3K4me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE198971_0_v_2_ncor2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-1026-SM-33HBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868201
Disease Progression	HuGE Navigator Gene-Phenotype Associations	1.0	null
PMC11684804-jci-135-174981-s193.xlsx-DESeq2_pseudobulk_AA_Ag_vs_Pre-Gene_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37341
K562_AC480_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160258
GTEX-XMD1-0011-R1A-SM-4AT4C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829725
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
496100324_FWM_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.24165
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.16259
SPI1-22096565-GC-B-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
Posterolateral visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10436
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A23K-01A-11R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial geniculate complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.874015
icSARA deltaORF6_12Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.13833
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94951
Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271581
NCIH810	CCLE Cell Line Gene Expression Profiles	1.0	1.46034
HARA	CCLE Cell Line Gene CNV Profiles	1.0	1.50546
ATF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E7-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7427_RPF2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.709314
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_11016_KO_Ppdpf_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.32742
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1447
ventrolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.891862
H3K79me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_ESRRB_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A5UA-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47196
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76268
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8369
GSE131649_4_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5747_NOP16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.730139
NCIH838	CCLE Cell Line Gene Expression Profiles	1.0	2.07976
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43087
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.955524
7512_RPS23_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.762483
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24426
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.9304
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9033_KD_FOSL2_SRP320789	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.33161
mitochondrial part	GO Cellular Component Annotations 2015	1.0	null
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87158
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46778
ARHGEF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08297
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.69141
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.43179
GTEX-S32W-0126-SM-4AD61	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01175
GSE148200_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HSD17B10	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QLQW-0226-SM-447BJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911136
mitochondrial chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.215063
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
mantle zone of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19714
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PCI-15A	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.90603
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paw	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.571
Kidney Chromophobe_KICH_TCGA-KN-8437-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
MRPL16	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7339546-12915_2020_793_MOESM2_ESM.xlsx-Table_S12-Table_S12_common_twin_genes_in_one_HMR_core_region_between_cattle_and_human_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
r2 part of the trigeminal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02921
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.072339
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V7-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C5orf22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12708
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MU-A8JM-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2814	CCLE Cell Line Gene Expression Profiles	1.0	2.21803
SP2	ENCODE Transcription Factor Targets	1.0	null
PABPC1	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF251	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59682
Basomedial amygdalar nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24724
TSR1	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-QQ-A5V2-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-UPIC-0726-SM-3GADW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10381
Perturb_3646_KO_HDAC1_ERP115567	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.7396
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TP53INP2_OE_GDS5054_385_mouse_Muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
HNF4A	ChEA Transcription Factor Targets	1.0	null
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01689
medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.978192
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.83474
2132_DDX56_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.665655
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.249531
HNRNPA1	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F7-01A-11R-A084-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
874_BOP1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.907757
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.873917
SARS-BatSRBD_72Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.91688
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863627
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
KARS	Pathway Commons Protein-Protein Interactions	1.0	null
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.17631
CAL-85-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.26395
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1301
IPC298	DepMap CRISPR Gene Dependency	1.0	2.08688
Perturb_5870_KD_Cpsf7_SRP336206	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.81991
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBED-0526-SM-47JY3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901933
6539_POLR1E_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.516825
vomeralnasalorgan.VMO.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.67809
Perturb_10852_KO_Smyd3_SRP057101	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.73848
MALSU1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.08163
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adrenal_4a	HPA Tissue Sample Gene Expression Profiles	1.0	0.843479
MRPS6	Pathway Commons Protein-Protein Interactions	1.0	null
small intestine	HPA Tissue Protein Expression Profiles	1.0	0.932281
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04697
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
heart muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.05929
NOP58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.54054
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anterior olfactory nucleus, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68881
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60091
GTEX-SUCS-0326-SM-32PLL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990893
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A59T-01A-21R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29415
Mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTPBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39327
THAP1	ENCODE Transcription Factor Targets	1.0	null
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bed  nucleus of stria terminalis, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.4274
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JN-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-PLZ6-1426-SM-2S1OQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829075
BB-87-SF89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204625
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFG8-0726-SM-3GILP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904771
upper (rostral) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.89054
translational elongation	GO Biological Process Annotations 2015	1.0	null
KAT2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZXDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34383
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40496
CLPX	Pathway Commons Protein-Protein Interactions	1.0	null
MECOM-23826213-KASUMI-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
7474_RPL4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.975309
Prostate adenocarcinoma_PRAD_TCGA-G9-6362-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
high-affinity iron permease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.8
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-0126-SM-4AD62	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40922
FA-63-WI26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333424
SLC25A5	Pathway Commons Protein-Protein Interactions	1.0	null
FOSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23927
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9132
POLR2AphosphoS2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6356072__F4	PFOCR Pathway Figure Associations 2023	1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_4516_Mut_Ep400_SRP081300	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.95101
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31085
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.923032
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2980-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.60648
all	GWASdb SNP-Phenotype Associations	1.0	0.040759
9449_TXNDC12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.681126
KCTD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05512
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.075239
2553_EIF3I_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.62133
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Organelle inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6329
r3 part of anteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86296
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4545
6071_PARK7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.694761
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.16641
GTEX-O5YT-0008-SM-4E3IQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24787
MRPS21	Pathway Commons Protein-Protein Interactions	1.0	null
GATA2_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNRPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2007
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9550_KO_Becn1_SRP255651	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.13871
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SP4	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-75-5147-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Yb body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.72
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testis	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-0.846236
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
DHX9	Pathway Commons Protein-Protein Interactions	1.0	null
7539_RPS9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.627327
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIC_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10453
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.03234
TAL1_01_41	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58744
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3627
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5556
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5374
SARS2	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPDL	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00452
GTEX-SE5C-0426-SM-4BRUI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.066
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim29_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S7SF-0426-SM-3K2B7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23427
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A8BK-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.877509
Autonomic neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE111247_14_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2808
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.894414
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_11172_KO_Klf15_SRP186285	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.0701
macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7437-01A-21R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE102505_4_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7220-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ovary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.704198
PSMD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33467
CREB1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CL-40	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
r3 part of vestibular sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37736
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.912272
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7496
KYSE70	CCLE Cell Line Gene Expression Profiles	1.0	3.1773
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100642_PCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33351
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
ESRRB-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.7883
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3575
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver Cirrhosis, Experimental	CTD Gene-Disease Associations	1.0	1.05349
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.543332
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ChIP_HCIF1_20581084	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
9816_WDR36_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.535198
H3K9ac_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.979382
SOX2-16153702-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12602_KO_miR424_SRP341198	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.87045
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of r2Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2426
SP1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5253_KD_Snd1_SRP311785	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
KYSE180	CCLE Cell Line Gene CNV Profiles	1.0	1.72164
1197_CARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.576516
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040845
SIX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
L363	CCLE Cell Line Gene Expression Profiles	1.0	1.36844
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of r4BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01151
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Taenia tecta, ventral part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44021
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.319199
Perturb_4326_KO_Zcchc8_SRP187429	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.46562
2321_DNTTIP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.569123
9684_UTP20_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.533728
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Orbital area, medial part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24187
superficial stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.92832
substantia innominata/basal nucleus, transitional part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07229
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
genital neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.258617
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9097
intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.83515
Perturb_15866_KD_BMI1_ERP013870	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.41599
Intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE123372,GSE123373_1_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF485	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE114258_3_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-A4BX-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7577_RSL24D1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.512924
NEDD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11117
GTEX-RUSQ-0826-SM-47JWW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15427
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.67807
ED-05-KX67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29164
Perturb_16697_KO_70L02Rik_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.30958
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.058105
r3 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.05244
GSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0025
GTEX-WFG7-0726-SM-3GIKO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40375
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15455
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LD-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JHOM2B	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50306
MYC-19079543-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG5-0626-SM-2S1PP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852312
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.926625
H3K4me3_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GNG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04084
Perturb_3661_KO_EZH2_SRP211748	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.47884
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.29317
GSE198165,GSE198166_0_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AD-14-QD12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253014
chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.095933
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
ZFP42-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.933572
Perturb_5252_KO_Klf2/Snd1_SRP311785	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.759431
Dorsal peduncular area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07691
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX21	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_757_KO_DNMT3B_SRP389363	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.43535
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10982_KO_Fads1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.69509
6533_POLR1A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.566384
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrial membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.28846
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7437_RPL13_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.762281
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
lung_3f	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.896174
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.926625
Perturb_11441_KO_TP53_SRP253428	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.53414
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
medial amygdala, anterodorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14774
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PUSL1	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6487-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A40G-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12355_KD_PRPF31_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.41201
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.482714
intermediate stratum of r4Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32313
GTEX-QEG4-0426-SM-33HC3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.945709
LC1SQSF	CCLE Cell Line Gene CNV Profiles	1.0	1.62829
RBBP5	ENCODE Transcription Factor Targets	1.0	null
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40269
Primary somatosensory area, upper limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35941
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r4 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32206
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OCUBM	DepMap CRISPR Gene Dependency	1.0	2.10765
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18085
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32174
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.54466
H3K27ac_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A61V-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA1_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91678
hsa-miR-340	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
intermediate stratum of r5Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12474
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.938953
Perturb_15403_KD_AR_SRP377764	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
mantle zone of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42839
2983_FAU_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.82216
ACCMESO1	CCLE Cell Line Gene Expression Profiles	1.0	1.75326
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-5778-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906028
184A1N4	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.21831
Perturb_16954_KO_MLX_SRP183152	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.88329
GSE200352_4_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1-22096565-GC-B-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-RWSA-0008-SM-47JYX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.647
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25451
FE-64-KC49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.55308
SG in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01072
GSE234637_3_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MRPL14	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PLZ5-0326-SM-3P614	GTEx Tissue Sample Gene Expression Profiles	1.0	0.995211
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	1.01174
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.471267
GTEX-N7MS-0008-SM-4E3JI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16484
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.49136
KYSE-70	COSMIC Cell Line Gene CNV Profiles	1.0	2.26395
organelle organization	GO Biological Process Annotations 2015	1.0	null
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.41844
ChIP_SMAD1_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.40627
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.268958
AC-50-FR41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.354323
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SB-29-ZH97_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.634919
PMC6356072__F4	PFOCR Pathway Figure Associations 2024	1.0	null
EPHA4_knockout_227_GSE34430	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.66713
Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7096_KO_Eif2ak3_SRP271084	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.87354
15988031-TableS5	GeneSigDB Published Gene Signatures	1.0	null
GSE153189_2_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229358
C20orf96	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25202
GSE213588_9_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100408_PCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.081
Oocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.849
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MRPL9	Pathway Commons Protein-Protein Interactions	1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.54822
Nucleus y	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0674
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HSPA1B	Pathway Commons Protein-Protein Interactions	1.0	null
mitochondrial gene expression	GO Biological Process Annotations 2025	1.0	null
intermediate stratum of r6BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.74388
ventrolateral prefrontal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.54399
HT1080	CCLE Cell Line Gene Expression Profiles	1.0	1.79951
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2061
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WH7G-0426-SM-3NMBJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03896
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01772
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
eye and adnexa disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.178403
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3668
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26448
layer 1 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.11365
single-organism organelle organization	GO Biological Process Annotations 2015	1.0	null
GSE81193_0_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.73081
MCCC2	Pathway Commons Protein-Protein Interactions	1.0	null
DMRT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8202
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF7L2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7509_RPS19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.657594
H3K4ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.1125
QC-90-PV99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209651
MRPS15	Pathway Commons Protein-Protein Interactions	1.0	null
mitochondrial translational termination	GO Biological Process Annotations 2015	1.0	null
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12498
H3K23me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
eed_20123906_mouse_embryonic_stem_cell_lof_mouse_gpl1261_gse19076	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.494495
GSE214823,GSE214824_5_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bed nuclei of the stria terminalis, anterior division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12768
GTEX-XAJ8-1326-SM-47JYT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47667
PE/CA-PJ15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.973228
outer CP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.886056
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PGAM5	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	94.2763
PMC4051124-1471-2164-15-256-S15.XLSX-WES_IPD-RBCK1_1-Target_RBCK1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10175786-Table4.XLSX-Sheet_1-GSE7410_AND_GSE63514_NOT_GSE9750_NOT_Ferrotosis_genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE235017_1_v_0_uba52_human	RummaGEO Gene Perturbation Signatures	1.0	null
EGR1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10365_KD_Setd2_SRP184682	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.22862
mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.17479
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ3S-2726-SM-4BOP2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.34202
NOA1	Pathway Commons Protein-Protein Interactions	1.0	null
Principal sensory nucleus of the trigeminal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05568
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AG-06A-31R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38429
7607_RUVBL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.504505
HS255T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54371
GABPA_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217873_1_v_2_nusap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.31506
GTEX-PSDG-1326-SM-48TD2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845396
ATP5A1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.47257
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81821
AD-06-OB47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233734
5707_NMD3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.60282
SW-480 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-0.826594
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2543
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TE-10	COSMIC Cell Line Gene CNV Profiles	1.0	2.26395
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20385
dorsal peduncular cortex, periventricular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54997
chr3_179570491_G_A_b38	GTEx eQTL 2025	1.0	1.70091
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.4174
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22797
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MRPL48	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-AA3A-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE200673,GSE200691_2_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPS10	Pathway Commons Protein-Protein Interactions	1.0	null
primary auditory cortex (core)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.885452
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26419
rosiglitazone_mus musculus_gpl8321_gds4021	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_CD19 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.61512
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POU2F2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-2.10021
substantia nigra, pars compacta, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.840895
874_BOP1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.600903
MIB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.77
2544_EIF3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.708213
parahippocampal gyrus, right, bank of the cos	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07188
GTEX-QDVN-1326-SM-48TZ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08307
mitochondrial gene expression	GO Biological Process Annotations 2023	1.0	null
GSE151689_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PF-382	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.0675
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPL15	Pathway Commons Protein-Protein Interactions	1.0	null
H3K79me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01689
Perturb_7912_KO_RNPC3_SRP367036	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.32698
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32634
Childhood Acute Lymphoblastic Leukemia	DisGeNET Gene-Disease Associations	1.0	null
GEMIN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27602
Vagina	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.538401
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.891166
RERFLCSQ1	CCLE Cell Line Gene Expression Profiles	1.0	2.56351
PML	ENCODE Transcription Factor Targets	1.0	null
Perturb_1679_KO_Nox4_SRP356837	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.18258
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
3395_GLIS1_ENST00000312233.2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.697355
Edema	CTD Gene-Disease Associations	1.0	1.38015
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.51726
9469_TYW3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.746002
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMPCA	Pathway Commons Protein-Protein Interactions	1.0	null
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.855
GSE93674_2_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164757,GSE164759_1_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01342
MTA3	ENCODE Transcription Factor Targets	1.0	null
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8343
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31513
Perturb_2717_KO_TET1_SRP110516	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.7305
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30613
ZEB1	ENCODE Transcription Factor Targets	1.0	null
GSE98755,GSE98756_1_v_0_fbxl19_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU761	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56969
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855038
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01689
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MRPS35	Pathway Commons Protein-Protein Interactions	1.0	null
liminal part of r3 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1592
CREB1-23762244-HIPPOCAMPUS-RAT	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19625
Perturb_2763_KD_CBX3_SRP077334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.69394
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21285
GTEX-RWSA-0626-SM-2XCBD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843647
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-2.29645
H3K4me3_Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6502
GTEX-TSE9-2226-SM-4DXUR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9674
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
ELF1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner CP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.985711
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
10751_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.712867
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04697
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
respiratory system cancer	GWASdb SNP-Disease Associations	1.0	0.281256
Lung adenocarcinoma_LUAD_TCGA-78-8662-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10624900-41467_2023_42825_MOESM13_ESM.xlsx-Module_3-ZNF195_ZNF195	Rummagene Transcription Factor Associations 2026	1.0	null
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4528_KD_Chaf1a_SRP060878	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.2588
eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.181222
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AIFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0799
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01974
HS274T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.5155
SOX17	ChEA Transcription Factor Targets	1.0	null
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ovary	HPA Tissue Gene Expression Profiles	-1.0	-0.951762
GTEX-RWSA-2426-SM-47JXR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80784
GSE157592_1_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nucleus of the lateral olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09818
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58008
Bed nuclei of the stria terminalis, posterior division, transverse nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10745
7481_RPL9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500322
THAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3991
NDFIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73631
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.801785
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8917_KD_ARID1A_SRP256204	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.63294
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.386048
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE134375_0_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1242
9210_TPP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.12169
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17440_Mut_Akt_SRP366791	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.43717
Ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.634
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.365136
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IJ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3706
Prostate	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.02263
8605_SURF6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.547602
4108_IMP4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.646376
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WZTO-1326-SM-3NM8X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848502
FLI1_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4710_KO_Sox9_ERP109172	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.87359
MYC-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-142-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
TestisLeydigCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.03604
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF263	ENCODE Transcription Factor Targets	1.0	null
superficial stratum of r4Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25457
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-4.00405
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0426-SM-3NM99	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833888
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE110580_1_v_0_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2059
MRPS31	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE62843,GSE64371_2_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6397
FST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62047
H3K9ac_Rectal Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.66402
Ebolavirus(ZEBOV)_3day_PBMCs_rNAPc2treated_21987740_GSE24943	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	0.629103
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2644
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1831
retina	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.024
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.878059
Lung squamous cell carcinoma_LUSC_TCGA-34-5929-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7169_RBM28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.795407
SU-DHL-10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TEAD4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
7463_RPL35_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.957082
CECR5	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH2172	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59924
Perturb_4488_KO_Rnu11_SRP309496	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.37294
ETS1	ChEA Transcription Factor Targets	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08943
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4640-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
ETS1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE91015_0_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PNPT1	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Infralimbic area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00628
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AH-0008-SM-48U2J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944191
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36348
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A42C-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.04049
ovary	HPA Tissue Protein Expression Profiles	-1.0	-2.58246
PMC6436215-13073_2019_626_MOESM2_ESM.xlsx-PCM-SP100_SP100	Rummagene Transcription Factor Associations 2026	1.0	null
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testis_7b	HPA Tissue Sample Gene Expression Profiles	1.0	1.04514
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2586_KD_RORC_SRP066204	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.21964
GSE193258,GSE193259_5_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
3871_HNRNPL_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.606983
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.57934
intracellular organelle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.067434
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_16947_OE_Mir181a1_SRP359086	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.96585
Adrenocortical carcinoma_ACC_TCGA-OR-A5JB-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4940_KO_Cbfa2t2_SRP061948	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.22247
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983934
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.632962
NKG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19421
retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.054813
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3696
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.09892
Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A6I9-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
11152_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.664899
internal segment of globus pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.888325
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48898
Perturb_10952_KO_70L02Rik_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.91326
ETS1-20019798-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
7522_RPS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.738185
Piriform-amygdalar area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23276
GTEX-PWOO-0526-SM-2S1Q3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19308
Perturb_10025_KD_TIAL1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.31427
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28362
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20286
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7432_RPL10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.765154
HCC1897	CCLE Cell Line Gene CNV Profiles	1.0	1.62881
MRPL11	Pathway Commons Protein-Protein Interactions	1.0	null
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
b104	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.175
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	1.32428
S0-EE-WJKI_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254219
STAT3	ENCODE Transcription Factor Targets	1.0	null
C6orf203	Pathway Commons Protein-Protein Interactions	1.0	null
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.22575
hsa-miR-3120-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GTEx Colon 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-16.2151
RDES	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45564
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55G-0526-SM-2TC5O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976884
retromammillary area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08894
SDHA	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1770	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.74308
GSE158320,GSE183351_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
964_C12ORF45_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.508724
939_BYSL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.553125
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HL-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5746_NOP14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.825328
TE441T	CCLE Cell Line Gene Expression Profiles	-1.0	-2.96067
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40519
GTEX-PSDG-1526-SM-48TCY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876991
BICR18	CCLE Cell Line Gene CNV Profiles	1.0	1.59994
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44597
RELA_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.926625
PMC4149371-pone.0105180.s010.xls-SOX2-GENE_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-92-7341-01A-31R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NELFE	ENCODE Transcription Factor Targets	1.0	null
protein complex disassembly	GO Biological Process Annotations 2015	1.0	null
MGAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25293
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
SPI1	ChEA Transcription Factor Targets	1.0	null
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00495
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.29216
PAX5	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5098-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
reproductive organ cancer	GWASdb SNP-Disease Associations	1.0	0.219482
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06701
Perturb_5206_KO_Dgcr8_SRP137729	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.72975
6215_PELP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.693628
10023_ZC3H18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.774699
RD-ES cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.513
MRPL44	Pathway Commons Protein-Protein Interactions	1.0	null
mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
GSE120612_6_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.901163
GTEX-VJYA-0826-SM-4KL1M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970856
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5084-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46F-01A-31R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9687_UTP6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.710837
large ribosomal subunit	GO Cellular Component Annotations 2015	1.0	null
7206_RCL1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.68135
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7646-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.72
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mitochondrion	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
subthalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.82741
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33203
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mitochondrial membrane	GO Cellular Component Annotations 2015	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.56491
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30744
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06292
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
39S ribosomal subunit, mitochondrial	CORUM Protein Complexes	1.0	null
1331_CCNJ_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.631244
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12842
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-TSE9-2826-SM-4DXTF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99498
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular component disassembly	GO Biological Process Annotations 2015	1.0	null
r3 part of ventral lateral lemniscal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06191
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	1.0	2.45491
superior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.901758
GATA1_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CALU-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.884562
periventricular stratum of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36696
mitochondrial translation	GO Biological Process Annotations 2025	1.0	null
NFYB	ENCODE Transcription Factor Targets	1.0	null
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.79126
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC25A6	Pathway Commons Protein-Protein Interactions	1.0	null
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5994
Lung adenocarcinoma_LUAD_TCGA-44-7660-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.956577
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Hypodermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.954
GSE140322_3_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NOL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22908
GSE178267_2_v_0_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05923
RNMTL1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE101112_6_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RWS6-1126-SM-47JXC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04788
TMLHE	Pathway Commons Protein-Protein Interactions	1.0	null
7508_RPS19BP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.733013
GSE112860_0_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_20_OE_Smarca5_SRP217699	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-12.4833
posteroventral (inferior) parietal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.988663
Hyperglycemia	CTD Gene-Disease Associations	1.0	1.08584
TT2609C02	DepMap CRISPR Gene Dependency	1.0	2.01451
organellar ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GTEX-V955-0126-SM-4JBH5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828339
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7169_RBM28_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.730686
Medial amygdalar nucleus, posterodorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.65812
GTEX-U4B1-1126-SM-4DXV3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2466
ED-00-OH22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220627
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270877
RPUSD4	Pathway Commons Protein-Protein Interactions	1.0	null
Mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
lung	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.06383
Perturb_10976_KO_Dlue7_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.92944
HNRNPA0	Pathway Commons Protein-Protein Interactions	1.0	null
HARS2	Pathway Commons Protein-Protein Interactions	1.0	null
3385_GLB1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.562017
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UJMC-0526-SM-3GAE3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960087
Bed nuclei of the stria terminalis, posterior division, strial extension	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.14552
HNRNPH2	Pathway Commons Protein-Protein Interactions	1.0	null
7475_RPL5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.917923
GTEX-SE5C-0626-SM-2XCDV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06263
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.05258
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JIMT-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13893
ZFR	Pathway Commons Protein-Protein Interactions	1.0	null
GSE137144_4_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
H2BK120ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
9841_WDR75_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.577544
H4K5ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_16589_KO_Mx_SRP133673	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.61444
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.55883
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287534
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE120612_7_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_14048_KD_TXNIP_SRP394013	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.53156
abnormality of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.116612
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.45293
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUN	ENCODE Transcription Factor Targets	1.0	null
mitochondrion	LOCATE Curated Protein Localization Annotations	1.0	null
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
MRPL47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5837
r1 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61027
bed nucleus of the stria terminalis, laterocentral division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3713
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.61131
layer 3 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52007
GABPA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0987
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961553
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_1743_KO_U2af1_SRP297129	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	19.5229
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.865598
Lung squamous cell carcinoma_LUSC_TCGA-56-7223-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.47765
NOP56	Pathway Commons Protein-Protein Interactions	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GTEX-U3ZN-2226-SM-3DB88	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968929
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043149
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.21673
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Perturb_3912_KD_Y14_SRP118481	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.253
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.36972
sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.165655
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r1 part of vestibulocerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05646
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2019
ZFP42	ChEA Transcription Factor Targets	1.0	null
OC-10-FB51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316495
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0931
Perturb_2319_KD_PRPF8_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.91027
optic nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.893359
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
METTL17	Pathway Commons Protein-Protein Interactions	1.0	null
GSE102757_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.840147
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02487
SP in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25997
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50743
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.208481
Perturb_14945_KD_Parp1_SRP102079	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.64659
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE242083,GSE242098_3_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_7474_KD_Chtopl_SRP144331	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.0421
NIPSNAP1	Pathway Commons Protein-Protein Interactions	1.0	null
496100395_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.44775
MRPL55	Pathway Commons Protein-Protein Interactions	1.0	null
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9535
amygdalohippocampal transition zone, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06372
NANOG	ChEA Transcription Factor Targets	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of male external genitalia	GWASdb SNP-Phenotype Associations	1.0	0.232294
Perturb_5043_KO_Adnp_SRP313259	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.19252
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.992622
Perturb_5207_KO_Ddx6_SRP137732	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.94886
HCFC1-20581084-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC12234789-41467_2025_61560_MOESM3_ESM.xlsx-Supplementary_data_1-Only_YY1_IP-MS_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72471
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10219
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YL-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
golgi apparatus	LOCATE Predicted Protein Localization Annotations	1.0	null
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HK1	Pathway Commons Protein-Protein Interactions	1.0	null
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.0981
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15716
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11995
Perturb_12627_KO_Bag6_ERP110252	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.84312
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7498_RPS10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51998
496100488_TCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.24293
7459_RPL31_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.656458
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16358
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32604
Acute lymphoblastic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
7458_RPL30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02635
SARS-ddORF6_60Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.52556
Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79823
HCC1569	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.11607
HOXB5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.5796
ZMPSTE24_Deficiency_GDS3775_506_mouse_Embryonic fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ATP5B	Pathway Commons Protein-Protein Interactions	1.0	null
VARS2	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPUL2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SNU668	CCLE Cell Line Gene Expression Profiles	-1.0	-1.8386
HT-144	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.98252
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.28738
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.587433
GSE209582_1_v_0_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QESD-0626-SM-2I5G4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90148
GTEX-R55C-1426-SM-48FED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86109
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73Q-01A-21R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_13231_OE_Rnaseh1_SRP056871	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-12.1372
FAM86B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1557
ChIP_NANOG_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Perturb_7922_OE_KMT2B_SRP388452	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.31923
organelle part	GO Cellular Component Annotations 2015	1.0	null
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SLC25A3	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14605
GSE162739_4_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907296
DMRTC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.936
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
5731_NOC4L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.628569
7460_RPL32_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.809267
testicular cancer	GWASdb SNP-Disease Associations	1.0	0.683009
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33332
r2 part of vestibular sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23469
TP53	JASPAR Predicted Transcription Factor Targets	1.0	null
ESRRB	ChEA Transcription Factor Targets	1.0	null
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1017
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Taenia tecta, dorsal part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0692
Perturb_6529_KO_YAP1/WWTR1_SRP212224	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.26597
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881284
FOS	ENCODE Transcription Factor Targets	1.0	null
7569_RRS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.856883
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980352
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5258
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49075
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
GSE186647,GSE217288_1_v_4_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K23ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
r3 part of trigeminal sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70643
GTEX-O5YT-0526-SM-32PK8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963955
septostriatal transition area (accumbens)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19671
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14646
r4 part of lateral vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25659
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.54022
Perturb_1885_KO_Mettl14_SRP269254	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.98697
Perturb_12207_Mut_TP53_SRP287851	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.58195
organelle inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.250389
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
mitochondrial matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.186087
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8336-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2377_KD_Cdk8_SRP292215	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.5134
Anterior olfactory nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35995
C10orf2	Pathway Commons Protein-Protein Interactions	1.0	null
RUNX1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE154577_13_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
2731_ESF1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.771202
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.57732
Facial motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42605
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Superior temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.923
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01689
eomes_23431145_e14dot5_neocortex_lof_mouse_gpl6246_gse43387	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.417181
JAG1_OE_GDS3571_40_human_endometrial stromal cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16318
Perturb_1335_KO_Esrra/Esrrg_SRP143464	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.40515
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.02438
SW 982	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.910269
periventricular stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39832
Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
heart_5a	HPA Tissue Sample Gene Expression Profiles	1.0	2.42762
FOXP2	ENCODE Transcription Factor Targets	1.0	null
SIX5_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nucleus of the lateral olfactory tract, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52332
SLC25A18	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_8492_KD_Mir34a_SRP133851	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.1311
NCDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00785
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6756575__F3	PFOCR Pathway Figure Associations 2024	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866365
KLF4-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC10898050-12967_2024_4947_MOESM2_ESM.xlsx-Table_S7-Table_S7_Differentially_expressed_genes_between_the_TCF7_CD8_memory_T_cells_and_the_other_memory_CD8_T_cells_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
ESRRB-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
r2 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21464
GTEX-XV7Q-0226-SM-4BRVL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10368
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.845217
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.527124
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.973228
NU-DUL-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.92862
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BFTC-905	COSMIC Cell Line Gene CNV Profiles	1.0	2.26395
NME4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XPT6-1626-SM-4B655	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2968
Bed nuclei of the stria terminalis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1032
TFB1M	Pathway Commons Protein-Protein Interactions	1.0	null
GSE165689_0_v_1_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3445_GNL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.618609
CDK8_knockdown_128_GSE30815	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.1222
GSE186440,GSE186443_3_v_7_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_3_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GI-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoma_burkitts(Daudi)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.5796
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H209	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.17209
7512_RPS23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.649813
IER5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47324
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.812518
YME1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10654
MELK_knockdown_150_GSE32873	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.29442
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.759805
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.27813
GTEX-XV7Q-2126-SM-4BRVX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913348
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.26249
YY1	ChEA Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NSUN4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328189
6537_POLR1D_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.508508
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.992611
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68122
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219682
GTEX-R55D-0126-SM-48FEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43265
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
RCHACV	DepMap CRISPR Gene Dependency	1.0	2.05428
RELA_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-RTLS-0326-SM-2TF6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829095
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7241
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.17027
ELF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIRT6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Frontal pole, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40331
Perturb_1048_KD_H19_SRP132802	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.60708
Combined oxidative phosphorylation deficiency 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.561
H4K20me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64097
Perturb_7800_KD_RRP6_SRP064143	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.20852
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.955688
HDAC6	ENCODE Transcription Factor Targets	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2986-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57011
periventricular stratum of r1Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09949
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23301
GSE203429_0_v_1_angptl8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.1169
CREB1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cingulate gyrus, retrosplenial part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.926248
Motor nucleus of trigeminal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40709
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.894414
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6493_PNO1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.536094
7432_RPL10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.796567
Perturb_218_KO_Uba6_SRP389127	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.969541
MRPL19	Pathway Commons Protein-Protein Interactions	1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.531138
1941_CTPS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.609756
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.826122
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bed nuclei of the stria terminalis, anterior division, fusiform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02689
Anterior olfactory nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04188
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.059183
NCI-H520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.99678
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TRA2B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE153871_5_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FIBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37094
MAX_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MAZ_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DLD	Pathway Commons Protein-Protein Interactions	1.0	null
301_ANAPC10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.588993
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18637
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral part of r4B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01223
Perturb_83_KD_HOXC4|HOXC6_SRP192852	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.96045
r3 part of lateral vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38875
Dhori Virus_24Hour_20090954_GSE17400	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.20665
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.57465
PCDHB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07364
YY1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JAK1_activemutant_61_GSE18239	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.27717
H3K56ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TCF7L2_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.840801
Perturb_1681_KO_Nox4_SRP356837	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.01496
4208_ISG20L2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.597541
PMC11655728-12672_2024_1562_MOESM2_ESM.xlsx-Sheet1-Hs_ESC_SOX2_targets_Boyer_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370338
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942152
GSE148066,GSE157787_9_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09915
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PHC1-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MFSD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68621
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
MRPL50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02173
ABC1	CCLE Cell Line Gene CNV Profiles	1.0	1.4378
TUFM	Pathway Commons Protein-Protein Interactions	1.0	null
external granular (germinal) layer of upper rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.876055
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE221633_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97274
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EO-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.90387
PMC4021073-1471-2407-14-278-S4.xlsx-Sheet1-Supplementary_Table_S5_Genes_with_GATA3_ChIP-seq_peak_within_10kb_from_transcription_start_site_TSS_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal facial shape	GWASdb SNP-Phenotype Associations	1.0	1.10754
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HD-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4841-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08088
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126777_3_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
8826_TEX10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.718456
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.926625
TBP	ENCODE Transcription Factor Targets	1.0	null
MATR3	Pathway Commons Protein-Protein Interactions	1.0	null
MRPL13	Pathway Commons Protein-Protein Interactions	1.0	null
GRPEL1	Pathway Commons Protein-Protein Interactions	1.0	null
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7497_RPS10-NUDT3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.622412
UBE2Z	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33566
TE-6	COSMIC Cell Line Gene CNV Profiles	1.0	2.26395
H3K79me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
7468_RPL37_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.596364
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6583
GTEX-XQ3S-0126-SM-4BOO9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830848
nucleus accumbens, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.923217
Perturb_14882_KO_H11_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.25435
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Mitochondrial ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.543
Oligospermia	CTD Gene-Disease Associations	1.0	1.0869
testis_7a	HPA Tissue Sample Gene Expression Profiles	1.0	1.01259
ECH1	Pathway Commons Protein-Protein Interactions	1.0	null
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.64247
globe disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.181222
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1996
Perturb_10317_KO_miR25_SRP188485	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.13581
intermediate stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08971
KASUMI2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67078
KAT2A	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-548x	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
ChIP_KLF4_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A617-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30662
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPS14	Pathway Commons Protein-Protein Interactions	1.0	null
Fatty Liver	CTD Gene-Disease Associations	1.0	1.37418
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE125403_7_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventromedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.925239
CEBPD	ENCODE Transcription Factor Targets	1.0	null
IMMT	Pathway Commons Protein-Protein Interactions	1.0	null
SMAD1	ChEA Transcription Factor Targets	1.0	null
GSE111247_2_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4798
3447_GNL3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.717437
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91548
neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.105262
RELA_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
20937356-TableS2	GeneSigDB Published Gene Signatures	1.0	null
7562_RRP15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.682716
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU1214	CCLE Cell Line Gene Expression Profiles	1.0	1.36633
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955849
TRIM28_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100430_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.10312
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.899794
NCIH1435	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7692
translation	GO Biological Process Annotations 2015	1.0	null
GTEX-OIZI-0126-SM-3NB13	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26172
ELF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0525
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
6887_PSMG4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.553471
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.409194
SUPV3L1	Pathway Commons Protein-Protein Interactions	1.0	null
Desipramine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T8EM-0126-SM-4DM5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82286
Perturb_5061_KD_Cnot10_SRP251834	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE229671,GSE229673_0_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
deep layers of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32152
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BE-79-QU25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352256
colon_8a	HPA Tissue Sample Gene Expression Profiles	1.0	0.832314
PMC7616765-EMS198548-supplement-Data_S2.xlsx-3_DEG_2D_and_3D-D9_Up_in_2D_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
LOVO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.31584
A-VN-1203-2004(H5N1)_Day1-10^2pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.67529
7459_RPL31_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.19896
KA-81-AG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213009
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16053
NCIH441_LUNG	CCLE Cell Line Proteomics	1.0	2.23458
Perturb_2313_KD_LUC7L2_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.21449
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7859
8886_THG1L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.64159
nucleus of the diagonal band, left, vertical division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.892383
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13674
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A560-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Longissimus lumborum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.606
7493_RPP40_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.587797
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fh1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.922
Perturb_11673_KD_SHFM3_SRP113334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.39222
5909_NVL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.51096
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mitochondrial ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
SLR21	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46634
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
1192_CARF_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.679395
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.15732
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49087
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.44753
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5037-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Spinal nucleus of the trigeminal, oral part, ventrolateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18171
principal sensory nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09812
TRMT10C	Pathway Commons Protein-Protein Interactions	1.0	null
ovary_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.1903
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	59.7614
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16637
Perturb_2103_KD_CDC73_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.60372
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05838
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351151
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IG-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA2_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5071
IGF2BP3	Pathway Commons Protein-Protein Interactions	1.0	null
SMARCB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53652
GTEX-QDVJ-0426-SM-2I5FW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02637
ATAD3A	Pathway Commons Protein-Protein Interactions	1.0	null
E2F1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Amisulpride_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184465
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
5702_NLE1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.684239
KDM4A	ENCODE Transcription Factor Targets	1.0	null
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SALL4	ChEA Transcription Factor Targets	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
GTEX-V955-1926-SM-4KL1L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.559
Neoplasms	CTD Gene-Disease Associations	1.0	1.26825
7471_RPL39_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.654242
primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.902019
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
7482_RPLP0_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.573095
CAPAN-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.26395
ZFP42-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AY-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.888869
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968536
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-NL4W-0008-SM-4E3I2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19969
WA-03-IF37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.417504
GSE128730_7_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4051124-1471-2164-15-256-S16.XLSX-WES_IPD-RBCK1_2-Target_RBCK1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_15677_KD_Srsf2_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.95386
Perturb_8011_KD_Ddx3_SRP324914	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.68792
QGP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.43494
MEOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3056
T47D	CCLE Cell Line Gene CNV Profiles	1.0	1.4653
GINS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13782
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.57648
structural molecule activity	GO Molecular Function Annotations 2015	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4582-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_13826_OE_Pdgfra_SRP302970	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.61489
embryonic lethality prior to organogenesis	MGI Mouse Phenotype Associations 2023	1.0	null
BICR22	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IRF4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TP53INP2_OE_GDS5053_312_mouse_Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.989041
Perturb_1350_KD_NSUN2_SRP212699	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.5491
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWOO-1326-SM-48TCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848213
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
Perturb_9556_KO_IKKa_SRP111864	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.8944
posterior part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22134
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01232
GTEX-O5YV-1126-SM-3LK73	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264525
6576_POP5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.510851
PMC7480058-95058-2020.08.29.20182899-10.xlsx-1ModuleKeyDrivers-Target_gene_Ensembl_that_KD_acts_upon_AR	Rummagene Transcription Factor Associations 2026	1.0	null
subthalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.96551
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.31282
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
RUNX1	ChEA Transcription Factor Targets	1.0	null
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Spinal nucleus of the trigeminal, oral part, middle dorsomedial part, ventral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19571
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.865487
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE128333_2_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE182680,GSE182683_5_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
LARP7	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910993
Lung squamous cell carcinoma_LUSC_TCGA-18-4721-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PCCB	Pathway Commons Protein-Protein Interactions	1.0	null
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.915385
MRPL12	Pathway Commons Protein-Protein Interactions	1.0	null
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2476
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HY-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H460	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01791
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	93.8244
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.832713
Sarcoma_SARC_TCGA-IS-A3K7-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73G-01A-22R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
eGFP-HDAC8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12748
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZP-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE80098,GSE80366_0_v_8_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FASTKD1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-PJ-A5Z9-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5738_NOL9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.0853
Weight Gain	CTD Gene-Disease Associations	1.0	1.07589
GSE222574_0_v_2_lmna_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.78656
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14401
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREM	ChEA Transcription Factor Targets	1.0	null
mitochondrial membrane	GO Cellular Component Annotations 2025	1.0	null
basolateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0214
SFXN1	Pathway Commons Protein-Protein Interactions	1.0	null
HS751T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46329
Perturb_10398_KD_BAF53A_SRP278652	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
facial motor nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.967623
Fog2_KO_GDS3659_152_mouse_adult heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Perturb_1446_KO_Tmem173_SRP221603	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.4877
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
male reproductive organ cancer	GWASdb SNP-Disease Associations	1.0	0.372889
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12139
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.406
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.500583
Perturb_10971_KO_Crbn_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.75402
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2113_DDX24_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.753807
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6422
mitochondrial translation	GO Biological Process Annotations 2023	1.0	null
superficial stratum of AHy	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.04715
859_BMS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.679267
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13259
SOX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8077
GTEX-PLZ6-0726-SM-3P619	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08424
Perturb_13921_KO_PPARGC1A_SRP314654	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.33059
Perturb_16626_KD_Sod1_SRP217736	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.55924
HCC15	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6606
2124_DDX47_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.808959
Organellar small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.065
organic substance biosynthetic process	GO Biological Process Annotations 2015	1.0	null
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.997667
Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J2-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MHHNB11	CCLE Cell Line Gene Expression Profiles	-1.0	-2.01058
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15716
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_10961_KO_Apom_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.01547
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-3394-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE162739_2_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2128_DDX52_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.594905
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
C1QTNF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62597
LAMTOR3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WFG8-0626-SM-3GILJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3328
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.855105
mitochondrial translational initiation	GO Biological Process Annotations 2015	1.0	null
RALY	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XMD1-0011-R11A-SM-4AT5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00568
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955167
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
7469_RPL38_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.763963
GTEX-RM2N-0008-SM-48FF3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46168
GSE162739_6_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H4K91ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
type ii diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.428943
7523_RPS3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.516134
UST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28683
Perturb_17550_KD_HMG20A_SRP354496	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.49131
MRPL40	Pathway Commons Protein-Protein Interactions	1.0	null
salivary gland	HPA Tissue Gene Expression Profiles	-1.0	-0.896615
1489_CENPP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.76018
K562_AG-490_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159091
GSE229671,GSE229673_2_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CEBPD_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4507-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1311
TestisIntersitial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.70984
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70Q-01A-13R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20829
DETROIT562_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	2.32704
Esrrg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4965
NCIH2170	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40749
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A69H-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.5921
vitamin c_homo sapiens_gpl570_gds3635	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21186
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A5R3-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0513
central nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.867379
Perturb_14372_KD_IGF2BP3_SRP131243	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.61421
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Prom_Prom-GWAS-RefSeq_Name_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE186005_1_v_2_klf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SKP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00146
r5 part of basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04792
dorsolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.58347
DF-00-BX35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.784644
hsa-miR-4699-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE168797_2_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
DEXI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12139
Perturb_1370_KD_IGF2BP1_SRP252209	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.6317
EE-98-PF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.8365
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942643
Ocular albinism 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.271
MCIXC	DepMap CRISPR Gene Dependency	1.0	2.07885
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_14737_OE_ADAR1_SRP250165	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.48449
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_78_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46907
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE120370_4_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE200352_5_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
r5 part of ventral parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.0927
JHH6	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66179
Lung squamous cell carcinoma_LUSC_TCGA-58-8387-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LBR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21822
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.60938
NCI-H838	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.09273
PTTG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1172
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59523
embryonic lethality prior to tooth bud stage	IMPC Knockout Mouse Phenotypes	1.0	null
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13184
Perturb_16739_KO_Gcn5_SRP271119	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.87905
Perturb_15041_KO_Klf2/Klf4_SRP095733	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.54757
939_BYSL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.526362
GTEX-S4P3-0626-SM-4AD59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866331
Medial amygdalar nucleus, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.70323
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27347
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.22658
9804_WDR12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.0435
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
5163_MPHOSPH10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.967867
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4797
Perturb_7009_KO_Lmna_SRP217125	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.90926
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.75221
OVCA 429	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.14758
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.06424
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J8-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
septopallidal core nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56775
pancreas	HPA Tissue Protein Expression Profiles	1.0	0.932281
DND-41	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.41317
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27373
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.7818
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.926625
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	1.12746
GSE186483_2_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELK4	ENCODE Transcription Factor Targets	1.0	null
Perturb_12935_KD_CDK9_SRP340404	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.55303
STAT1	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE140607_1_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-P44H-1126-SM-48TBU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916071
placenta	HPA Tissue Protein Expression Profiles	1.0	0.932281
MTPAP	Pathway Commons Protein-Protein Interactions	1.0	null
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31389
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TP53INP2_OE_GDS5054_387_mouse_muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CREB1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle	GO Cellular Component Annotations 2015	1.0	null
MRPL49	Pathway Commons Protein-Protein Interactions	1.0	null
SNU503	CCLE Cell Line Gene CNV Profiles	1.0	1.69083
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07246
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.38498
Perturb_5553_OE_BAHD1_SRP149805	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.83916
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15736
2321_DNTTIP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.588629
embryonic lethality prior to tooth bud stage	MGI Mouse Phenotype Associations 2023	1.0	null
primary motor cortex (area M1, area 4)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.900693
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PHB	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Nucleus of the lateral olfactory tract, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53809
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KYSE-450	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.26744
GTEX-N7MS-0626-SM-2YUN7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.938644
PLCPRF5	CCLE Cell Line Gene Expression Profiles	-1.0	-2.38712
RKN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00026
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49595
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.91987
hsa-miR-4796-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GTEX-QMRM-1226-SM-447C6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0554
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.23778
ILF3	Pathway Commons Protein-Protein Interactions	1.0	null
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.8874
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BE-01B-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skin_5f	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.839555
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POU2F2	ENCODE Transcription Factor Targets	1.0	null
MRPS25	Pathway Commons Protein-Protein Interactions	1.0	null
POU2F2_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CAOV3	CCLE Cell Line Gene CNV Profiles	1.0	1.64922
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899319
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3396
LETM1	Pathway Commons Protein-Protein Interactions	1.0	null
MRPS27	Pathway Commons Protein-Protein Interactions	1.0	null
GSE218060_7_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATAD3B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE226439,GSE226441_6_v_2_hnf4g_human	RummaGEO Gene Perturbation Signatures	1.0	null
TestisSeminiferousTubule	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.07666
SSBP1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11707_KD_NUDT21_SRP127253	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.10393
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-0008-SM-48U2K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29288
7466_RPL36_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.73882
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32046
CDK9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12224
TE5	CCLE Cell Line Gene CNV Profiles	1.0	1.33752
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279014
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278352
PMC4728380-ncomms10153-s8.xlsx-High_affinity_MYC_Targets-Unnamed_0_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
seminal vesicle	HPA Tissue Protein Expression Profiles	1.0	0.932281
GSE130081,GSE130082_4_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ISTMES2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.92666
H3K27ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VW-A8FI-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.859619
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SKM-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.50173
MBD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1ML-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of r3Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70643
translation	GO Biological Process Annotations 2025	1.0	null
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
ATF2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VDAC1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
H2BK12ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3042_FCF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.563577
H3K36me3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG8-1626-SM-4LVMB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906034
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.6746
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.38045
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42298
PDK3	Pathway Commons Protein-Protein Interactions	1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_5_TbID_-biotin_ERM_proteo-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
E2F1-26619117-HEPATOCYTES-MOUSE-LIVER	ChEA Transcription Factor Targets 2022	1.0	null
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14786
ACAD9	Pathway Commons Protein-Protein Interactions	1.0	null
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.56536
7518_RPS27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.528743
GSE167224,GSE168147_3_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KAT2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	1.0	null
orbital frontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.45863
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04145
LK2	CCLE Cell Line Gene Expression Profiles	1.0	1.513
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.51791
DE-34-DT75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.811395
Perturb_11228_KO_Srf_SRP050501	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.59267
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.53712
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3848
MRPL28	Pathway Commons Protein-Protein Interactions	1.0	null
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9152_KD_DDX21_SRP327839	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.4425
RBFA	Pathway Commons Protein-Protein Interactions	1.0	null
7450_RPL23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.712909
HE-80-BQ08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247889
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.93277
TAF1	ENCODE Transcription Factor Targets	1.0	null
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.20502
Prelimbic area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23746
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.607455
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13960_KO_YAP1_SRP194022	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.66049
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.56995
Perturb_16360_OE_Ppargc1a_SRP278337	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
CREB1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16185
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830514
E2F1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.59766
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Prefoldin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.748
KDM5A	ChEA Transcription Factor Targets	1.0	null
Perturb_14201_KD_HNF4A/GATA6_ERP108557	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.1624
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MRPS7	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-3665	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
CCNT2	ENCODE Transcription Factor Targets	1.0	null
MRPL2	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QC-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7407-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral part of MM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02457
mantle zone of r6BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18449
RK-13 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.505
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
HCV JFH1_120Hour-Huh7_5_1_None_GSE29889	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.65528
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.943798
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05192
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046174
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.123
MRPL4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86467
gonadal neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.332312
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_15462_KD_FOXA1_SRP353748	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.87159
Intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93836
GTEX-TSE9-2626-SM-4DXV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860597
MDAMB468_BREAST	CCLE Cell Line Proteomics	1.0	2.25
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02197
Mitochondrial translation initiation	Reactome Pathways 2024	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.958055
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
outer SZ in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38111
9366_TSR2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.88024
GTEX-QEL4-2126-SM-447AE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867086
GLDC	Pathway Commons Protein-Protein Interactions	1.0	null
mitochondrion organization	GO Biological Process Annotations 2015	1.0	null
IRF4	ENCODE Transcription Factor Targets	1.0	null
GSE239844_8_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0353
Rhabdomyosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.701
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.67036
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
GSE140936,GSE140938_2_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TFCP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.897
OCIM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61741
MRPS30	Pathway Commons Protein-Protein Interactions	1.0	null
layer 3 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1879
Perturb_5112_KD_Med10_SRP325525	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.52043
juvenile	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.731442
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AL-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEx Heart 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	-1.0	-3.04787
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1464
anterior digastric muscle trigeminal motor cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.03275
Perturb_7192_OE_DIMT1_SRP267960	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.55477
GTEX-WI4N-2726-SM-3LK7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01727
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.83474
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IE-01A-21R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCFC1	ENCODE Transcription Factor Targets	1.0	null
GTEX-TMMY-1726-SM-4DXTD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.844388
Anterior olfactory nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.09045
Perturb_2317_KD_PRPF31_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.45097
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
7453_RPL26_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06352
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951221
superficial stratum of r6BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02921
SNG-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.097698
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.830604
organelle inner membrane	GO Cellular Component Annotations 2023	1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PML_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13486_KO_1810027O10Rik_ERP013119	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.44162
deferasirox_homo sapiens_gpl570_gds3558	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mantle zone of r3Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37623
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.92835
MYCN-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
KYSE-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.09122
8826_TEX10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.704673
hsa-miR-486-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BE-13	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.38083
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04937
Lung adenocarcinoma_LUAD_TCGA-64-1677-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mitochondrial translation elongation	Reactome Pathways 2014	1.0	null
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19026
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.64247
POLDIP2	Pathway Commons Protein-Protein Interactions	1.0	null
H4K91ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-224	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
mantle zone of r6Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21946
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.5771
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.33826
F36P	DepMap CRISPR Gene Dependency	1.0	2.00562
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63U-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mitosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.822
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8054-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE197562_0_v_3_nox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.466292
AFG3L2	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25X-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TALL-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.10577
HCC1937	CCLE Cell Line Gene Expression Profiles	1.0	1.40768
SIX5_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner SZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04212
LU65_LUNG	CCLE Cell Line Proteomics	1.0	2.09838
PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521	Rummagene Transcription Factor Associations 2026	1.0	null
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5707_NMD3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.603623
Ventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69727
ATP5H	Pathway Commons Protein-Protein Interactions	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
GTEX-QXCU-0008-SM-48FCH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12191
H3K4me1_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.311341
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.524044
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00086
abnormal respiratory system morphology	GWASdb SNP-Phenotype Associations	1.0	0.146755
Perturb_7179_KO_TrEx_SRP163035	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.82104
mantle zone of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18449
Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-7082-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mitochondrial outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.47442
HGC27	DepMap CRISPR Gene Dependency	1.0	2.02911
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.95613
GTEX-U3ZN-0826-SM-4DXSZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960868
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55702
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04837
cerebellar cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.50582
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_14568_KO_Got2_SRP348541	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.50466
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
POLRMT	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HNRNPR	Pathway Commons Protein-Protein Interactions	1.0	null
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12075
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SIX5	ENCODE Transcription Factor Targets	1.0	null
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50897
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.7144
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abducens nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.52306
496100418_TCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.60978
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23441
7449_RPL23A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.39524
H3K4me1_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-2026-SM-4LVMW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893149
H3K14ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.125978
Perturb_13825_KO|OE_Nf1/Pten/Efgr_SRP302970	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.96501
abnormal external genitalia	GWASdb SNP-Phenotype Associations	1.0	0.232294
Organellar ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.534
GTEX-UPJH-0926-SM-4IHKA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857359
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S7SE-0005-SM-2XCEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895548
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05017
GTEX-XGQ4-0226-SM-4GIDS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0638
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519223
Perturb_12606_KO_Lin28a/Lin28b_SRP300815	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6073
inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.884134
Oxoglutarate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.839
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.20032
CHD2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8009-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
subthalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.91323
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6206
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3931
GSE112860_5_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.34742
ISL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0145
KASUMI2	CCLE Cell Line Gene CNV Profiles	-1.0	-2.06558
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992881
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.90452
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.89579
T-lymphoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.683
GSE131377_1_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SWAP70	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22968
ATF1	ENCODE Transcription Factor Targets	1.0	null
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37135
GTEX-Q2AH-1526-SM-48TZG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62245
PLCPRF5	CCLE Cell Line Gene CNV Profiles	-1.0	-2.4158
Organellar ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
YY1_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R53T-0226-SM-48FEH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939663
MRPS23	Pathway Commons Protein-Protein Interactions	1.0	null
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	4.04113
mantle zone of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21368
Perturb_9365_OE_NRF2_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.50966
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35009
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75159
4684_LSG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.92363
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX3	ENCODE Transcription Factor Targets	1.0	null
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10908
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5354_KO_Dux_SRP201141	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.65094
GSE228106_0_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SUCLG2	Pathway Commons Protein-Protein Interactions	1.0	null
ZSCAN25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14377
ASTE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.90076
Lung squamous cell carcinoma_LUSC_TCGA-22-5471-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
10231_ZNF236_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.712518
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U4B1-1526-SM-4DXSL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54547
5735_NOL6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.719938
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.941873
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MRPS26	Pathway Commons Protein-Protein Interactions	1.0	null
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.502419
Acute Myeloid Leukemia_LAML_TCGA-AB-2810-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
spleen	HPA Tissue Protein Expression Profiles	-1.0	-1.65543
H2BK120ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2GZ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N7-A59B-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1304	COSMIC Cell Line Gene CNV Profiles	1.0	2.26395
PRDX5	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4539	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
TCFAP2C-20176728-TROPHOBLAST STEM CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4698	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE166315_5_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MINPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20927
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PW2O-0826-SM-48TC5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16701
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GTEX-U4B1-0326-SM-3DB8K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20775
GTEX-NPJ8-2126-SM-3MJGK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915232
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.8078
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.896322
DMRTA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8447
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.45068
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAB40AL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47618
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267654
translation	GO Biological Process Annotations 2023	1.0	null
dorsolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.845482
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.993523
PPP1R26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10206
Sarcoma_SARC_TCGA-QC-A7B5-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100351_FWM_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.56222
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_SGI-1776 free base_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157311
ACAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00207
kidney	GTEx Tissue Gene Expression Profiles	1.0	0.867299
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.160264
7451_RPL24_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0633
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ALDH1B1	Pathway Commons Protein-Protein Interactions	1.0	null
r3 part of trigeminal transition zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63243
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_2235_KO_Irf8_SRP270893	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.82745
dentate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.43167
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.714314
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941954
superficial stratum of r3Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.94451
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37538
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y8-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
GSE154577_2_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924979
RKO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_MYCN_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE182680,GSE182683_0_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HSD17B4_KO_GDS3468_503_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-CoV_48Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.52898
primary auditory cortex (core)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.909841
Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A7D7-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3182
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACADVL	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-46-3768-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33367
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281187
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7368
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_15446_KD_ETV4_SRP212208	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.19772
GSE158834_1_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_13254_KD_Ncaph2_SRP073037	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.37506
BA-39-OX47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286352
YY1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
P31-FUJ	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.18507
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intermediate stratum of r3Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71106
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.837235
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ALDH18A1	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11042_KO_Tmem174_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.48528
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GTEX-S4Q7-1226-SM-4AD5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63387
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.507544
Adrenocortical carcinoma_ACC_TCGA-OR-A5K2-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
7577_RSL24D1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.522816
GSE240439_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LMX1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7262
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34792
H2BK5ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.76147
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.843695
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.60768
Perturb_10022_KD_PSIP1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.31439
Kidney Chromophobe_KICH_TCGA-KM-8441-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EW1	DepMap CRISPR Gene Dependency	1.0	2.08985
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.83474
TMEM37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10311
GSE228181_4_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8661_TAF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.45314
PARD6G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04451
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043581
Perturb_10023_KD_RCC2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.7498
OVCA 429	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.36194
3343_GFI1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.609809
superficial stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10628
inner CP in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18741
posteroventral (inferior) parietal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20469
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.57635
prostate gland	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-0.868882
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	3.19385
PLC/PRF/5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.76396
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24293
ISCA1	Pathway Commons Protein-Protein Interactions	1.0	null
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11662
6576_POP5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.508928
periventricular stratum of Dg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29946
GSE140997_4_v_6_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6659
VSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0807
GATA3_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TEAD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thyroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.3362
Medial amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51236
MRPS34	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
T-REx 293 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.204
TAF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68G-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11440_KO_RB1/TP53_SRP253428	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.36938
2124_DDX47_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.619202
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CPT2	Pathway Commons Protein-Protein Interactions	1.0	null
NDUFS8	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	1.0	null
inner CP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27193
Lung adenocarcinoma_LUAD_TCGA-50-5066-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE242290_1_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
VZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.910733
GBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5798
superficial stratum of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.11365
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2061
hela	HPA Cell Line Gene Expression Profiles	-1.0	-1.50971
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203642
GTEX-RUSQ-2126-SM-47JXK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58466
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.50893
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bed nucleus of the accessory olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60895
GTF2B	ENCODE Transcription Factor Targets	1.0	null
HOXA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9023
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
OVCA433	COSMIC Cell Line Gene CNV Profiles	1.0	2.26395
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RARS2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155433
H3K4me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE149124,GSE149128_2_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YME1L1	Pathway Commons Protein-Protein Interactions	1.0	null
Ribonucleoprotein complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
RERFLCSQ1	CCLE Cell Line Gene CNV Profiles	1.0	2.34104
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
cortico-medial group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.855551
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.22263
PPP1R35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82052
mitochondrial inner membrane	GO Cellular Component Annotations 2025	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_4day-MOI-10^4_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.55969
GSE119345_0_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDAMB436	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62937
PMC3230611-pone.0028509.s004.xls-Sheet1-Supplementary_Table_S2_The_list_of_273_differentially_expressed_genes_after_transfection_of_STAT6_specific_siRNA_in_NCI-H460_cells_STAT6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81843
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NFYB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mRNA_SOX2_16767105	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
SARS-dORF6_24Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.79245
liver	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.4444
OVCAR-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.913784
SP2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-150	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.49624
MYCN-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7467_RPL37A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.980363
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	145.2
GTEX-S32W-1926-SM-4AD63	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866337
HOXD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11379
GSE227698_2_v_1_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
1040_C1ORF131_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.510426
Stat6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.7738
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Lapatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196473
H3K4me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
7713_SDAD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.63285
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.0691
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
gastrointestinal system cancer	GWASdb SNP-Disease Associations	1.0	0.130992
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
lymphoblastoid cell line	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.18121
GTEX-U8XE-1126-SM-3DB8W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894845
intermediate stratum of r4BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.058
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25285
7311_RIOK1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.583041
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14328
PMC12769604-13402_2025_1147_MOESM6_ESM.xlsx-Table_S4_3_Venn-Scissor_AND_Prognosis_NOT_Tumor_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_2797_KD_RORC_SRP066204	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.94641
ED-71-GA72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260919
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5259-01A-31R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.11923
testis_7d	HPA Tissue Sample Gene Expression Profiles	1.0	1.29319
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08863
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.570381
infection	GAD High Level Gene-Disease Associations	1.0	0.293278
Perturb_2376_KD_Cdk8_SRP292215	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.99401
GTEX-TMMY-1126-SM-4DXSX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28215
GTEX-XV7Q-0826-SM-4BRV7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4788
organellar large ribosomal subunit	GO Cellular Component Annotations 2015	1.0	null
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.52091
ETS1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CIITA	ChEA Transcription Factor Targets	1.0	null
GTEX-WFJO-0626-SM-4LVMC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90843
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36376
GSE131649_4_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346562
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Plant crown	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.711
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100358_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14658
TARS2	Pathway Commons Protein-Protein Interactions	1.0	null
MFE-280	COSMIC Cell Line Gene CNV Profiles	1.0	2.26395
Perturb_11960_KD_RAD6B_SRP258673	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.90401
RPS21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03665
9682_UTP15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.565134
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919436
PMC3355086-pgen.1002728.s003.xlsx-Tabelle1-HEY2_downregulated_HEY2	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.985883
DDX47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14067
inner CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.15272
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrion	LOCATE Predicted Protein Localization Annotations	1.0	null
hypothalamic amygdala	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0448
KDM5B	ENCODE Transcription Factor Targets	1.0	null
r4 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67026
E2F1	ChEA Transcription Factor Targets	1.0	null
ATF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28506
NCIH661	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53555
PLC/PRF/5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-3.05126
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5513_KD_TCF4_ERP112500	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.41479
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 2 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92656
SARS-CoV_48Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.26104
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_13_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80564
GSE181513_0_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-VJYA-1426-SM-4KL1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17542
MAFF	ENCODE Transcription Factor Targets	1.0	null
TP53INP2_OE_GDS5054_276_mouse_SKM-Tg - Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.99861
COR-L26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.887684
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4PP-0008-SM-48TDV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900472
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08493
GSE154219_0_v_2_cholestyramine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18264
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.23481
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21931
GSE116930,GSE116935_1_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198165,GSE198166_8_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DHX30	Pathway Commons Protein-Protein Interactions	1.0	null
6611_PPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.729572
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CHCHD1	Pathway Commons Protein-Protein Interactions	1.0	null
Mitochondrial large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.721
C170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
GSE232624_4_v_5_ethanol_human	RummaGEO Drug Perturbation Signatures	1.0	null
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_2980_KD_Mbnl1/Mbnl2_SRP057123	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.47997
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A553-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TGBC1TKB	DepMap CRISPR Gene Dependency	1.0	2.03473
emboliform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04501
CLPTM1L	Pathway Commons Protein-Protein Interactions	1.0	null
H4K20me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AOB, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10628
Perturb_14215_KO_Psen2_SRP254653	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.51342
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EWS-FLI1-20517297-SK-N-MC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCI-H1694	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.5132
ARHGEF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13236
UQCRC1	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SNOS-1126-SM-4DM67	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83461
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931528
Perturb_6989_KO_Ptcd1_SRP120583	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.46786
Perturb_6675_KD_HDAC9_SRP159451	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.39682
VHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4134
STAT3_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.7348
r3 part of the trigeminal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.94451
5747_NOP16_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.642469
NOTO	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5706
PMC6412103-mmc1.docx-5-M00695_ETF_P_8_350E-5_N_428_31_5_1_TEAD2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE102870_3_v_9_nr1h4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Parahippocampal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.959
Perturb_16713_KO_Prkab1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.67772
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
7478_RPL7L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.848902
Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6219_PES1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.647226
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE164874_5_v_14_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-8499-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CNOT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01505
Prostate adenocarcinoma_PRAD_TCGA-2A-A8W1-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
amygdaloid complex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14893
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.35718
ANKRD13D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78917
primary auditory cortex (core)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.97929
BICR22	COSMIC Cell Line Gene CNV Profiles	1.0	2.26395
intermediate stratum of SeDg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03845
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r6 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14528
HADHA	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_15275_OE_Foxa1_SRP189075	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
liminal part of the r5 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7908
UBIAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06528
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Bed nuclei of the stria terminalis, anterior division, oval nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09238
GTEX-T5JW-0226-SM-4DM7I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900106
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.938953
SW480	CCLE Cell Line Gene Expression Profiles	1.0	1.36135
island of Calleja major	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.05023
2658_EP400_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.532824
RUNX1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
KDM5A	ENCODE Transcription Factor Targets	1.0	null
GTEX-PLZ5-1526-SM-3P5ZX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14231
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.33
GTEX-U3ZM-1626-SM-4DXSK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46309
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.05928
H2BK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GR-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5732_NOL10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.53162
POLR2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00368
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5109-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	153.455
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_14214_KO_App_SRP254653	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.23322
PMC10103678-11427_2023_2316_MOESM4_ESM.xls-THP1_mRNA_binding_Protein_PMA-Unnamed_3_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
RERF-LC-SQ1	COSMIC Cell Line Gene CNV Profiles	1.0	2.26395
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.819513
FBL	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GRSF1	Pathway Commons Protein-Protein Interactions	1.0	null
mitochondrial membrane	GO Cellular Component Annotations 2023	1.0	null
JARID1A-20064375-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Hypoxia_Astrocyte_GSE4483	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.905024
MYC-19030024-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51708
Lung squamous cell carcinoma_LUSC_TCGA-L3-A524-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0377
amygdaloid complex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08089
KCL-22	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1329
HEY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03115
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.85778
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_10215_KO_Csnk1a1_ERP021472	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.68114
Polar tube	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.79
GPHA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30681
POLR2A_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830909
Perturb_10953_KO_83F24Rik_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.83858
layer 1 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27523
Perturb_13145_KD_Atrx_SRP194170	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.68653
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10941
MYC-19079543-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4167
SUCLG1	Pathway Commons Protein-Protein Interactions	1.0	null
KE-37	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.20003
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_MYC_19079543	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.25619
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219587
NDUFB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75053
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.05796
RTN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23621
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-S7SF-0526-SM-3K2BC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11813
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
CA-68-KG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240169
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.72717
H3K23ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
7569_RRS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.60298
VDAC3	Pathway Commons Protein-Protein Interactions	1.0	null
7438_RPL14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.19747
YY1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ezh2_KO_GDS3765_515_mouse_Primary preadipocyte cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
TCF12_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spinal nucleus of the trigeminal, oral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27887
organelle inner membrane	GO Cellular Component Annotations 2015	1.0	null
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40368
Perturb_9035_KD_FOSL1_SRP320789	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.23879
SIRT6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_7541_KO_NSUN6_SRP273753	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.80536
7481_RPL9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.867648
GTEx Heart 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	-1.0	-8.32771
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28408
Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
Mitochondrial matrix	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.79632
Seminal vesicle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Mitochondrial translation initiation	Reactome Pathways 2014	1.0	null
NALM-6	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.12608
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68067
cortico-medial group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.47085
hsa-miR-3121-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
hsa-let-7b-5p	MiRTarBase microRNA Targets	1.0	null
hsa-miR-3920	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
8645_TACC3_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.504919
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0041
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.73329
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
r4 part of descending trigeminal sensory nucleus, oral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06504
Ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
neoplasm of the genitourinary tract	GWASdb SNP-Phenotype Associations	1.0	0.180802
HCFC1-20581084-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SOX2-16153702-HESC-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE77795_2_v_1_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4V-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RVPV-0008-SM-47JYW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22251
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7600_KO_LEF1_ERP109990	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.88453
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
H3K79me2_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.896799
2551_EIF3G_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.634407
H3K27ac_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
YBX1	Pathway Commons Protein-Protein Interactions	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26422
GSE113734_3_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inner CP in (rostral) midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.94917
NFYA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829739
Perturb_2326_KD_SF3B3_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.47619
Perturb_10310_KO_3110043O21Rik_ERP013119	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.08599
Perturb_3913_KD_Y14_SRP118481	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SKHEP1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44658
GTEX-T2YK-0008-SM-4DM6M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931105
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7476_RPL6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.82956
parvocellular part of the r9LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	4.38513
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8976
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19398
MTG1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.12222
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.90533
H3K79me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE201309_5_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_14_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.516198
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.9949
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.971717
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.971158
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
intermediate stratum of r5Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08738
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6997
UQCRC2	Pathway Commons Protein-Protein Interactions	1.0	null
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.066648
KYSE-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.84262
HS 683	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.930897
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Mitochondrial ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14377
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966162
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.44496
anterior olfactory area, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.11365
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A78R-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.897881
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19713
SP2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OAT	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8162
ADCK3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3098_KO_Leprel2_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.72812
GTEX-V1D1-0726-SM-4JBH7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851051
GSE179880_1_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
YY1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_5201_KD_Wdr43_SRP132494	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.68808
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.78327
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.774153
PMC6379092-elife-39598-supp2.xlsx-KLF2_target_genes-Mitochondrial_Translation_KLF2	Rummagene Transcription Factor Associations 2026	1.0	null
vincristine_homo sapiens_gpl570_gse7556	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
3677_HEATR1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.795628
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YF-01A-12R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LC4-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.369
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24521
GSE104508_0_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7451_RPL24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.987932
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8504
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sirolimus_mus musculus_gpl1261_gse5332	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
bronchus	HPA Tissue Protein Expression Profiles	1.0	0.932281
GSE224763_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30408
medial amygdala, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.79607
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NANOG-16518401-CHIP-PET-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEx AdiposeTissue 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-14.4537
nucleus of Darkschewitsch, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08982
posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.833763
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 895.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.94346
Lung Neoplasms	CTD Gene-Disease Associations	1.0	1.09047
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3698
8738_TBL3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.567169
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.328002
CREB1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.826565
Perturb_16700_KO_Blk_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.73643
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5EA-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.32536
PHC1	ChEA Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-A4DF-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7403_KD_HNRNPA2B1_SRP010280	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.41585
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1915	CCLE Cell Line Gene Expression Profiles	1.0	1.84711
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.42897
cd8 cells	HPM Cell Type and Tissue Protein Expression Profiles	1.0	0.939952
ESR1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8629
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.996885
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.541144
H3K36me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.669645
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.9925
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.2012
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.74523
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OOBJ-0008-SM-3NB26	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16809
Nucleus of the lateral olfactory tract, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59564
r2 part of trigeminal sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14702
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lymph node	HPA Tissue Protein Expression Profiles	-1.0	-1.05929
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.26621
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10208
OCIAML3	DepMap CRISPR Gene Dependency	1.0	2.01985
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25285
BE-81-QL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.534497
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE137144_5_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.79185
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7056_KO_Ogg1_ERP107154	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.56109
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.886587
RUNX3	ENCODE Transcription Factor Targets	1.0	null
HOXC13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8366
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43252
dorsal thalamus_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.850933
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.049959
NDUFS3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14946
CE-23-HP88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209346
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
KYSE180	CCLE Cell Line Gene Expression Profiles	1.0	2.38001
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03222
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8459
Bed nuclei of the stria terminalis, anterior division, anteromedial area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20738
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JE-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GADD45GIP1	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046789
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.84409
r5 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07443
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.52364
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.64307
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.042455
H3K9me3_Fetal Heart	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
colorectal cancer	GWASdb SNP-Disease Associations	1.0	0.683009
mitochondrion	GO Cellular Component Annotations 2015	1.0	null
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
7585_RTF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.645519
Perturb_2897_KO_Il33_SRP076391	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.50917
r2 part of trigeminal transition zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82421
MOV10	Pathway Commons Protein-Protein Interactions	1.0	null
Flower stalk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.796
GSE207514,GSE207515_2_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3594_GTPBP4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.537642
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0219
CAOV-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.47202
7476_RPL6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.22763
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.01776
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Spinal nucleus of the trigeminal, oral part, rostral dorsomedial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66147
testis_7f	HPA Tissue Sample Gene Expression Profiles	1.0	0.858227
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7479_RPL7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00998
mantle zone of r4Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30911
ribonucleoprotein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
USF2	ENCODE Transcription Factor Targets	1.0	null
ERBB2_druginhibition_8_GDS2139	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.54352
primary motor cortex (area M1, area 4)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36427
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242083,GSE242098_3_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111102,GSE111105_1_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE233112_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.01668
Perturb_3713_KO_PIWIL1_SRP188921	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.8056
orbital frontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08723
NFATC1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39621
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC11214527-mmc5.xlsx-TP53-gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_14944_KD_Nmnat1_SRP102079	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.44903
Cortical amygdalar area, anterior part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20694
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1938
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.56681
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8711
NFYA	ENCODE Transcription Factor Targets	1.0	null
21205295-TableS1	GeneSigDB Published Gene Signatures	1.0	null
PANC 05.04	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.831925
LARP1	Pathway Commons Protein-Protein Interactions	1.0	null
cytoplasmic chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.214017
Weight Loss	CTD Gene-Disease Associations	1.0	1.22566
Spectrosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.565
STAT1	ENCODE Transcription Factor Targets	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.25697
ATF2	ENCODE Transcription Factor Targets	1.0	null
GSE231648_1_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
r4 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3264
IGF2BP2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE71491_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S7PM-0626-SM-4AD4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	2.88223
GSE166536_3_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
3445_GNL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.825137
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
mitochondrial translation	GO Biological Process Annotations 2015	1.0	null
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCLAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE166315_5_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.36387
HSPA9	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.85096
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01459
GTEX-RTLS-2326-SM-46MUH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01101
496100335_PCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.4845
PMC9643473-Table1.xls-MAF_0_005-Gene_refGeneWithVer_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
Lymphoid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
Perturb_3067_KO_Adig_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.69831
GTEX-XMK1-0326-SM-4B652	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19359
H3K4me1_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MRPL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26721
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.981033
Perturb_17613_KI_FOXP2_SRP225889	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.1841
LN-229	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31439
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BXPC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.893726
embryonic lethality prior to organogenesis	IMPC Knockout Mouse Phenotypes	1.0	null
Perturb_11534_KD_THOR_SRP121007	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.76143
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5525
OXA1L	Pathway Commons Protein-Protein Interactions	1.0	null
inferolateral temporal cortex (area TEv, area 20)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.861601
mitochondrial crista	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.93785
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38368
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7038
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23824
Lung squamous cell carcinoma_LUSC_TCGA-39-5019-01A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151119_2_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13824_KO_Nf1/Pten_SRP302970	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.38071
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03417
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.432287
superficial stratum of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31235
RELA	JASPAR Predicted Transcription Factor Targets	1.0	null
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.47496
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06035
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XYKS-0226-SM-4BRW3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939483
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.46233
Perturb_3379_KO_Pgd_SRP309436	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	18.4089
GTEX-SUCS-0008-SM-4DM53	GTEx Tissue Sample Gene Expression Profiles	1.0	1.171
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2337_KD_WBP11_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.65091
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the testis	GWASdb SNP-Phenotype Associations	1.0	0.332312
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67488
GTEX-RUSQ-0226-SM-47JWT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32293
SP in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01807
STAT5A	ENCODE Transcription Factor Targets	1.0	null
Cortical amygdalar area, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13687
intermediate stratum of r2Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40709
7525_RPS3_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.727443
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13480_KO_Bmal1_SRP260650	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.97275
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933296
YY1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the male genitalia	GWASdb SNP-Phenotype Associations	1.0	0.211818
HC-01-FD24_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340004
r9 part of the basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03373
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32178
H3K79me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922865
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17037
lateral septal nucleus, intermediate part, periventricular	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36967
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05088
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48179
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.5813
H3K9ac_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126777_0_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100628_FWM_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.5139
layer IIIu of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.34543
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.37013
CTCF_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8629-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE153189_2_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
4684_LSG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.775321
r1 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0588
Inferior temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.725
Medial amygdalar nucleus, anterodorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22773
blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.776568
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
layer 2 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13569
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5640240-ppat.1006668.s013.xlsx-MAX_ChIP_shEP400-1-Unnamed_6_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
YY1-23942234-MYOBLASTS AND MYOTUBES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
NUGC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830909
lateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.886161
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42603
SALL4-22934838-CD34+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21128
HSD17B7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06719
GTEX-NL3G-0008-SM-4E3JX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23226
intermediate stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29467
6534_POLR1B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.810703
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30723
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318284
RAMOS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855038
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94576
GTEX-WFG7-0826-SM-3GIKU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89758
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7115
MRPL54	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KDM5B	ChEA Transcription Factor Targets	1.0	null
r4 part of trigeminal sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31132
Perturb_5004_KO_Rinf_SRP200002	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.21656
PMC9643473-Table1.xls-MAF_0_005-HGVS_gene_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH650	CCLE Cell Line Gene CNV Profiles	-1.0	-2.27224
Perturb_15753_KO_Ezh2_SRP096837	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
55S ribosome, mitochondrial	CORUM Protein Complexes	1.0	null
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5883
Perturb_16584_KO_Mir2182_ERP130060	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.75814
PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
CL-40	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_5251_KO_Klf2_SRP311785	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
mantle zone of AOV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3191
GTEX-X5EB-0526-SM-46MVP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.997315
KIAA0391	Pathway Commons Protein-Protein Interactions	1.0	null
Mitochondrial translation	Reactome Pathways 2014	1.0	null
Spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01223
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25183
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
COX4I1	Pathway Commons Protein-Protein Interactions	1.0	null
DLG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42814
BD-96-HO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245869
GSTZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17344
GTEX-O5YT-1326-SM-3MJGR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937509
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.44877
PMC6886551__F4	PFOCR Pathway Figure Associations 2023	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A59V-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5744
ZFX_KD_GSE43021_130_human_NOMO1	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Perturb_12296_KD_RORC_SRP066204	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.12464
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34605
TOV112D	DepMap CRISPR Gene Dependency	1.0	2.00131
MYCN	ChEA Transcription Factor Targets	1.0	null
EGR1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22757
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X8HC-2726-SM-46MUA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919346
HACD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0923
Prostate adenocarcinoma_PRAD_TCGA-VN-A88R-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE222445_2_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
7442_RPL18A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.781397
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Tofacitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141093
Perturb_2318_KD_PRPF8_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.13555
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.665021
Lung adenocarcinoma_LUAD_TCGA-35-5375-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25518
GD-46-BU97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220924
irf8_00000000_splenic_cd11bplusgrdash1_hdash2b_gen_background_lof_mouse_gpl6887_gse39228	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.03471
MRPL51	Pathway Commons Protein-Protein Interactions	1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.396973
r4 part of ventral parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02548
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77687
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K9ac_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
intermediate stratum of 5BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04947
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31472
MTIF2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.67294
Perturb_12347_KD_AQR_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.43457
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13065
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A857-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.40668
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-5_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.830909
2622_EMG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.19165
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963396
Lung squamous cell carcinoma_LUSC_TCGA-77-7142-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
17699763-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.87243
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I1-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251884
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
macromolecular complex subunit organization	GO Biological Process Annotations 2015	1.0	null
CREB1	ChEA Transcription Factor Targets	1.0	null
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56109
HEBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03794
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909315
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.687183
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CSNK1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13954
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Microsporidian	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.949
7499_RPS11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.75354
GATA3_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
DNAJA3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54877
LC-2-ad	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.94709
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of r2Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02921
7561_RRP12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.683531
H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ATF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC25A11	Pathway Commons Protein-Protein Interactions	1.0	null
visual pathway disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.886799
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLIRP	Pathway Commons Protein-Protein Interactions	1.0	null
HOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0139
GTEX-XLM4-1526-SM-4AT6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7924
inner SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.991761
BV173	CCLE Cell Line Gene Expression Profiles	-1.0	-2.2459
GTEX-XXEK-1726-SM-4BRVB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847066
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5881-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
XD-44-FJ34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267915
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8239
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S3XE-1726-SM-3K2AM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860415
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.900898
MRPS11	Pathway Commons Protein-Protein Interactions	1.0	null
lung cancer	GWASdb SNP-Disease Associations	1.0	0.683009
Perturb_6972_OE_Cdk8_SRP102453	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-17.7122
heart_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.17575
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.1091
r4 part of magnocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24456
CHD2	ENCODE Transcription Factor Targets	1.0	null
VZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.31143
5735_NOL6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.729298
testicular neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.585136
GSE149139_1_v_0_carm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.739944
H3K79me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
6574_POP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.824375
7497_RPS10-NUDT3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.665811
primary auditory cortex (core)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25627
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	3.24385
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.581
Adrenocortical carcinoma_ACC_TCGA-OR-A5L3-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7502_RPS14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.556078
SP in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07512
Cell Transformation, Neoplastic	CTD Gene-Disease Associations	1.0	1.07022
biosynthetic process	GO Biological Process Annotations 2015	1.0	null
5089_NIFK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.627395
GSE203329_2_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
substantia nigra, pars compacta, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.22739
4780_MAK16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.581365
Leukemia_promyelocytic-HL-60	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.02005
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.0961
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UPIC-1126-SM-4IHLO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88607
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11965
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.881
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
5734_NOL12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.515224
glis3_19805515_embryonic_pancreas_lof_mouse_gpl1261_gds3812	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.441157
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.74954
icSARA deltaORF6_30Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.62691
GSE182680,GSE182683_10_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_12361_KD_SF3B5_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.31959
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7871-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228213
FLAD1	Pathway Commons Protein-Protein Interactions	1.0	null
KYSE70	CCLE Cell Line Gene CNV Profiles	1.0	2.92643
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.06564
KYSE270	CCLE Cell Line Gene CNV Profiles	1.0	1.80926
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.55199
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.632518
DE-28-XP50_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292566
Cochlear nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12804
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4W-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.173905
GSE137144_3_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_7day-MOI-10^3_None_GSE44445	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.82459
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.926625
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BICR22	CCLE Cell Line Gene CNV Profiles	1.0	2.22457
SP2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12207
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1A7-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7312_RIOK2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.533355
THNSL1	Pathway Commons Protein-Protein Interactions	1.0	null
KLHL21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01714
7458_RPL30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.808447
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	110.377
oculomotor nuclear complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.62222
Perturb_4716_KD_Hnrnpu_SRP331236	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.63404
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MV-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SUCS-1326-SM-4DM5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71271
r5 part of magnocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12722
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.88915
A549	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34967
GSE216043_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
amygdaloid complex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08409
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.43184
H3K79me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.50259
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	1.0	null
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW-620 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-0.826594
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37135
Mitochondrial large ribosomal subunit - 2	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864753
CC-48-OM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.570251
Perturb_4_KO_Pabpn1l_SRP226170	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.16462
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.614
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE154577_7_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K56ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PANC 05.04	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01041
Perturb_1808_KO_Arhgef2_SRP186268	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.0254
Perturb_12492_KD_PELP1_SRP351131	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.9338
Perturb_7095_KO_Perk_SRP309948	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.84301
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NOMO-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
6887_PSMG4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.580291
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NUDUL1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.01434
MAX	ENCODE Transcription Factor Targets	1.0	null
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2805
Perturb_9367_OE_PIK3CA_SRP158425	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.38293
7312_RIOK2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.701106
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.941339
GTEX-OHPM-0008-SM-4E3IP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868228
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
inner SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.871987
NGRN	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30046
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2097
TE-26-XS06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213358
7523_RPS3A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.516112
intermediate part of r6B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18543
Perturb_5813_Mut_U2af1_SRP266807	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.80213
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.350245
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44198
GTEX-XGQ4-1526-SM-4AT6H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950809
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-V1D1-2126-SM-4JBH4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04026
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NKX6-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3612
PMPCB	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_6324_KD_AdipoR1_SRP377446	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.81147
2226_DIMT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.777739
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.272632
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37544
NB7	DepMap CRISPR Gene Dependency	1.0	2.11879
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41874
Perturb_7180_KO_TrEx_SRP163035	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.39357
1614_CINP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.512344
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-J1-A4AH-01A-31R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
Perturb_4720_KD_Tp53_SRP331236	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Medial amygdalar nucleus, posterodorsal part, sublayer a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45605
IZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.945553
IRF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-OOBJ-2126-SM-3NB1N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81657
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6685
membrane	LOCATE Curated Protein Localization Annotations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MF-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE201668_0_v_1_ncor2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE135350_2_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PTOV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2264
GSE86507,GSE86509_0_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
translational initiation	GO Biological Process Annotations 2015	1.0	null
GSE163862_2_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_943_KO_Sftpa1_SRP246320	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.81292
FUCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26271
TNP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04601
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bounding membrane of organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.052687
SIN3A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5021-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null