association dataset threshold value standardized value TRMT6 Pathway Commons Protein-Protein Interactions 1.0 null SA-32-CC58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.409849 Lung GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.591842 Magnesium chelatase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.891 Perturb_13336_KD_Pou2f1_SRP149831 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.89619 cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.68296 BRD-K14534138 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32103 CPSF2 Pathway Commons Protein-Protein Interactions 1.0 null H3K79me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SIRT6 ENCODE Transcription Factor Targets 1.0 null GSE114883_1_v_2_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null 17910759-TableS5 GeneSigDB Published Gene Signatures 1.0 null NDUFS1 Pathway Commons Protein-Protein Interactions 1.0 null SF3B3 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_6064_KD_RPF1_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 CB-16-SY72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.44893 H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K05125666 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04199 CNOT3-19339689-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-UTHO-0011-R2A-SM-3GIKC GTEx Tissue Sample Gene Expression Profiles 1.0 2.86157 H3K79me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HOXC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.8227 FUBP1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34759 mediodorsal nucleus of thalamus_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02296 RRP15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83389 GSE158834_7_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DCUN1D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.068 AC-28-RT00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.239435 TE-87-FM14_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.223807 EP300_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mitochondrial translation termination Reactome Pathways 2014 1.0 null RPL17 Pathway Commons Protein-Protein Interactions 1.0 null MRPS28 Pathway Commons Protein-Protein Interactions 1.0 null PAX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS-12-BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.902175 membrane-enclosed lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.057603 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN010_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.70935 BRD-K63383299 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55939 GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.3499 DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.73724 TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2818 GTEX-P44H-0006-SM-2XCFB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29894 PAX5 ENCODE Transcription Factor Targets 1.0 null TEAD4_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenal cortex cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.436 PRDX5 Pathway Commons Protein-Protein Interactions 1.0 null MRPL40 Pathway Commons Protein-Protein Interactions 1.0 null JHH5 CCLE Cell Line Gene Expression Profiles 1.0 1.42369 SRP14 Pathway Commons Protein-Protein Interactions 1.0 null FERMT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00556841 C7orf50 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-N7MS-0011-R11A-SM-2HMJS GTEx Tissue Sample Gene Expression Profiles 1.0 2.25324 intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.044163 TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_13_SOX11 Rummagene Transcription Factor Associations 2026 1.0 null LHX9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.8033 18310505-TableS7 GeneSigDB Published Gene Signatures 1.0 null MCU Pathway Commons Protein-Protein Interactions 1.0 null TRPM7_overexpression_305_GSE23102 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.1397 BRD-K56341841 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32984 Adrenal gland disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.24 NO11 DepMap CRISPR Gene Dependency 1.0 2.00628 H3K4me1_Brain Germinal Matrix Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPJH-0001-SM-3NMDE GTEx Tissue Sample Gene Expression Profiles 1.0 1.8064 LBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.1584 TFEB-21752829-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1419 CCLE Cell Line Gene CNV Profiles -1.0 -1.43448 TSR1 Pathway Commons Protein-Protein Interactions 1.0 null HOXD8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4344 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_16849_KO_Hnrnph1_SRP068520 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 NONO Pathway Commons Protein-Protein Interactions 1.0 null GTEX-UPK5-0003-SM-3NMDI GTEx Tissue Sample Gene Expression Profiles 1.0 1.09564 JHOS4 CCLE Cell Line Gene Expression Profiles 1.0 1.45704 Perturb_14038_KO_Dnmt1/Dnmt3a/Dnmt3b_SRP337936 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.9766 MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.975736 CHCHD1 Pathway Commons Protein-Protein Interactions 1.0 null IZUMO4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00603904 GB-96-WX99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.22718 16651409-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null NFYB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.40123 POLR3C Pathway Commons Protein-Protein Interactions 1.0 null inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00174 POLR2C Pathway Commons Protein-Protein Interactions 1.0 null TAF1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ERVV-1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63292 organellar ribosome COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-XMD3-2326-SM-4AT5H GTEx Tissue Sample Gene Expression Profiles 1.0 0.899943 ARCN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59341 SF539 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.848045 DBH_KO_GDS4324_362_mouse_Embryonic heart E10.5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null mediodorsal nucleus of thalamus_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.889644 H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Alexander Disease_CNS - Brain - Olfactory Bulb (MMHCC)_GSE977 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.38076 Phosphomannomutase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.819 Retrosplenial area, ventral part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10118 RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K82362034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61519 CA-48-JF51_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.332717 CTNND1 Pathway Commons Protein-Protein Interactions 1.0 null Primary visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27992 BRD-K21565985_XYLAZINE_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 8651_TAF10_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.613855 BRD-K20798215 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80929 YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.57897 POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CB-32-EI69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.701224 PMC5848610-supp_gr.228809.117_Supplemental_Table_S3.xlsx-Table_S3F-Supplemental_Table_S3F_ZFX_binding_pattern_clustering_information_for_genes_with_promoters_bound_by_ZFX_related_to_Figure_2I_ZFX Rummagene Transcription Factor Associations 2026 1.0 null CREB1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MHH-PREB-1 GDSC Cell Line Gene Expression Profiles 1.0 2.19814 DUSP16 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00490298 MUT Pathway Commons Protein-Protein Interactions 1.0 null IE-38-FB31_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.262513 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EEF1G Pathway Commons Protein-Protein Interactions 1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null K562_Mesna_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151439 TRMT10C Pathway Commons Protein-Protein Interactions 1.0 null CPSF7 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-PWN1-0726-SM-48TDR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.88203 Perturb_15321_OE_Nrf2_SRP298724 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.85378 HOXA4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5184 GTEX-XV7Q-2926-SM-4BRUL GTEx Tissue Sample Gene Expression Profiles 1.0 0.969565 Pancreas GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.762923 UA-39-TN76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.277648 H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08498 GTEX-OHPK-0426-SM-3MJH3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841021 POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDC73 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44935 hsa-miR-1224-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 COX7C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16364 H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null FOSL1_KO_GSE43695_680_mouse_lung, PBS treatment GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-OHPL-1626-SM-2HMIR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03482 GSE216273,GSE216292_0_v_1_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null ATP11B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21631 RPL24 Pathway Commons Protein-Protein Interactions 1.0 null medial portion of the shell Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.41722 ME2 Pathway Commons Protein-Protein Interactions 1.0 null PODXL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46114 BRD-K13113551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.00324 Perturb_15544_KD_Pten_SRP199649 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.0377 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CMAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67805 YY1-23942234-MYOBLASTS-AND-MYOTUBES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null r7 part of the dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57973 GTEX-R55C-1826-SM-3GADI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.916194 NDUFA13 Pathway Commons Protein-Protein Interactions 1.0 null cerebellar cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.54 MEIS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.1703 Lung squamous cell carcinoma_LUSC_TCGA-66-2768-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles -1.0 -2.09639 MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K94766933 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33907 CTCF_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal endopiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48799 NR3C1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS21BM CCLE Cell Line Gene Expression Profiles 1.0 1.41327 CXCR5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00576647 GSE122378_0_v_1_carmil3_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1 ENCODE Transcription Factor Targets 1.0 null 15474998-tableS1c GeneSigDB Published Gene Signatures 1.0 null Mitochondrial translation initiation Reactome Pathways 2024 1.0 null S0-EE-YEKU_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.206829 BRD-K48188521 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78891 CST3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00712791 5910_NXF1_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.53767 E2F6_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216043_10_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null BC-56-CP81_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.36582 H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KDM1A ENCODE Transcription Factor Targets 1.0 null GTEX-SIU8-0006-SM-2XCE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03102 AIFM1 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN015_MCF10A.TP53.M_24H:F22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.5233 GSE120612_7_v_2_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null nucleus subceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06939 BHLHE40_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null VDR ChEA Transcription Factor Targets 1.0 null U-937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.915554 RCHACV DepMap CRISPR Gene Dependency 1.0 2.00258 BRD-K47756270 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13537 BRD-K89742282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33501 CDC42EP5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00789889 BD-48-ZT65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.362092 abnormality of the urinary system GWASdb SNP-Phenotype Associations 1.0 0.110516 EIF4H Pathway Commons Protein-Protein Interactions 1.0 null MRPL17 Pathway Commons Protein-Protein Interactions 1.0 null LN235 CCLE Cell Line Gene Expression Profiles -1.0 -1.54158 SIX5_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A763-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01558 FARS2 Pathway Commons Protein-Protein Interactions 1.0 null FE-56-PV35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.145 intracellular membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null BRD-K39649774 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64139 BRD-K17979415 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04927 NC-27-AD53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.663866 GSE114013,GSE114014_1_v_3_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C3-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HC-74-HM63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.523571 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Metabolism of proteins Reactome Pathways 2024 1.0 null BRD-K64797043 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06338 DDX23 Pathway Commons Protein-Protein Interactions 1.0 null HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LENEP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00547871 centromedian nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.91939 Bladder Urothelial Carcinoma_BLCA_TCGA-S5-A6DX-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AR-20517297-VCAP-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K48407262 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00352 K562_Cyclocytidine HCl_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.015787 BRD-K97537859 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06635 GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.37804 STAT5A ENCODE Transcription Factor Targets 1.0 null Olig2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.8888 GTEX-TKQ1-0003-SM-3NMAE GTEx Tissue Sample Gene Expression Profiles 1.0 1.29599 r8 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05151 Perturb_5341_KO_Mbd1/Mbd2/Mbd4/Mecp2_SRP337936 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.88004 PBX3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FB-66-UU47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.94877 MAX_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X585-0011-R6A-SM-46MVJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.50342 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null layer 4 of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56123 CPT2 Pathway Commons Protein-Protein Interactions 1.0 null S100A10 Pathway Commons Protein-Protein Interactions 1.0 null NFATC1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-X6-A7WC-01A-12R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PABPN1 Pathway Commons Protein-Protein Interactions 1.0 null IL7R LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00766548 GSE193258,GSE193259_5_v_6_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PVOW-2626-SM-32PL8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07456 POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ4-0006-SM-2S1NY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1167 DE-99-OT37_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20994 BRD-K89660028 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55847 GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15057 Primary somatosensory area, upper limb, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51436 HC-01-FD24_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.5074 MSTO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07639 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BARX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.8504 SKIV2L2 Pathway Commons Protein-Protein Interactions 1.0 null GSE233548_3_v_0_plscr1_human RummaGEO Gene Perturbation Signatures 1.0 null CEBPD_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-0011-R11A-SM-2YUMS GTEx Tissue Sample Gene Expression Profiles 1.0 1.01327 H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MYB-26560356-CHIP-SEQ-TH2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -2.3353 GSE169152_3_v_4_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null STK33_knockdown_50_GSE15151 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.91935 GTEX-QMRM-1226-SM-447C6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09102 iPS-18 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.49523 EB-67-WB79_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.231605 DDX47 Pathway Commons Protein-Protein Interactions 1.0 null SRSF1 Pathway Commons Protein-Protein Interactions 1.0 null GSE216274,GSE216292_4_v_1_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null SLC1A3 Pathway Commons Protein-Protein Interactions 1.0 null FOXA1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Anterior olfactory nucleus, external part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41926 POU3F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.1675 mediodorsal nucleus of thalamus_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.31368 BRD-K04378630 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35261 MRPS11 Pathway Commons Protein-Protein Interactions 1.0 null RUNX3 ENCODE Transcription Factor Targets 1.0 null HS 839.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.0775 Perturb_3088_KO_Fam210b_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.03719 GSE70499_3_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null FASTKD1 Pathway Commons Protein-Protein Interactions 1.0 null 20_ABCB10_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.61913 EIF3M Pathway Commons Protein-Protein Interactions 1.0 null SNRPD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48835 KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Translation Reactome Pathways 2024 1.0 null CHD1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null T84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.71687 FC-20-EQ58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.695921 H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RPS27 Pathway Commons Protein-Protein Interactions 1.0 null CE-23-HP88_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.19109 Hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20316 translation GO Biological Process Annotations 2025 1.0 null BSX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.3275 dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.43605 reticular nucleus of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.15831 TEAD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KAT2A ENCODE Transcription Factor Targets 1.0 null RPL8 Pathway Commons Protein-Protein Interactions 1.0 null gata4_16914500_e9dot5_atrioventricular_canal_lof_mouse_gpl1261_gds3663 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.13222 YY1_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF708 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07946 CHD2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST ENCODE Transcription Factor Targets 1.0 null GTEX-O5YV-0326-SM-2I5H2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0655 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF7L2_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Primary somatosensory area, mouth, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.89022 single-organism organelle organization GO Biological Process Annotations 2015 1.0 null GTEX-S3XE-1826-SM-3K2B4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.894639 MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.60929 ASH2L-23239880-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-WHSB-0005-SM-3LK7C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31222 primary auditory cortex (core)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.826845 DMS 273 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05628 PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_14_MYC Rummagene Transcription Factor Associations 2026 1.0 null mantle zone of r8BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0606 female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053137 FOXA1-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K72317601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22773 FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.16528 Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.52718 ZNF444 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07651 CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null C19orf12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.331 organellar ribosome GO Cellular Component Annotations 2015 1.0 null preoptic region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.941565 ZZZ3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null caudal ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.60596 PA-75-VL17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.748929 LONP1 Pathway Commons Protein-Protein Interactions 1.0 null H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null amygdaloid complex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.843419 CREB1 ENCODE Transcription Factor Targets 1.0 null VC-79-JG59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.311181 GSE157594_5_v_2_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4074-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Rabies CVS-11_7day-Brain_22116324_GSE30577 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.80062 QARS Pathway Commons Protein-Protein Interactions 1.0 null KIF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09943 SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K77554584 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19773 SARS-ddORF6_48Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.06066 chronic kidney failure GWASdb SNP-Disease Associations 1.0 0.756064 USP39 Pathway Commons Protein-Protein Interactions 1.0 null periventricular stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58063 GSE116810_5_v_4_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null EVX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.8907 Acute Myeloid Leukemia_LAML_TCGA-AB-2830-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Veliparib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.018958 TARS2 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H1FX Pathway Commons Protein-Protein Interactions 1.0 null SIX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.4009 RBM14 Pathway Commons Protein-Protein Interactions 1.0 null ZR751 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.24662 ATAD3A Pathway Commons Protein-Protein Interactions 1.0 null HE-80-BQ08_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.363549 5231_MRPL48_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.664132 GTEX-OIZH-2626-SM-2HMJM GTEx Tissue Sample Gene Expression Profiles 1.0 1.04234 PELO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65158 GTEX-S7SE-0011-R7A-SM-2XCDI GTEx Tissue Sample Gene Expression Profiles 1.0 1.49011 BRD-K46126513 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65567 Lung adenocarcinoma_LUAD_TCGA-64-1678-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NGRN Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DDX18 Pathway Commons Protein-Protein Interactions 1.0 null RDH13 Pathway Commons Protein-Protein Interactions 1.0 null Adrenal gland cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.395 Perturb_8509_KO_Bmal1_ERP009958 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.1429 UBTF_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PCBP1 Pathway Commons Protein-Protein Interactions 1.0 null SNU668 CCLE Cell Line Gene CNV Profiles 1.0 1.36683 BRD-K26758344 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32309 8126_SLU7_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.790386 BRD-K71944493 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09974 u698 HPA Cell Line Gene Expression Profiles 1.0 1.15832 GTEX-POYW-0826-SM-2XCEM GTEx Tissue Sample Gene Expression Profiles 1.0 1.20766 HNF1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.3323 EPAS1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00587126 GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.85953 GSE144231_3_v_1_cxcr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null intermediate stratum of r8BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04995 hypothalamus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.368624 XRCC6 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K72997741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15219 JA-85-SW39_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.484254 EXOSC2 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN013_HEPG2_24H:K04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1051 RALYL Pathway Commons Protein-Protein Interactions 1.0 null chr11_73780061_C_T_b38 GTEx eQTL 2025 1.0 1.75225 imatinib_homo sapiens_gpl96_gds3043 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POU5F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SE-15-AV21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.369676 TAF1_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K83477969 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30896 GSE158834_7_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF35 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.865 GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.26032 Perturb_10781_KO_Ahr_SRP326814 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.92196 MPP89 CCLE Cell Line Gene CNV Profiles -1.0 -2.14913 ECI1 Pathway Commons Protein-Protein Interactions 1.0 null GSE169571_5_v_4_dexamethasone_mouse RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gracile nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0271 COLO205 CCLE Cell Line Gene Expression Profiles 1.0 1.65182 primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.48931 ZSCAN21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.302 primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02004 BRD-K64055724 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76727 NFIC_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null NOC3L Pathway Commons Protein-Protein Interactions 1.0 null ING4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0074253 Perturb_13172_KD_Birc6_SRP115807 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.90544 UNCX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.4793 HSC4 CCLE Cell Line Gene Expression Profiles 1.0 1.55716 MBD4_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7432-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K91399333 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20015 FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null 6868_PSMD14_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.596194 amygdalohippocampal transition zone, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.29516 CRCGN015_MCF10A_48H:B22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.16653 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MV-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null PRKDC Pathway Commons Protein-Protein Interactions 1.0 null YWHAG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18368 posterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.852999 ALDH18A1 Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_7_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null TBP_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.43721 GSE57871_11_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null CLEC2D LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00805144 GTEX-XBEW-0006-SM-4AT4E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.96025 APP Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null 15902281-TableS1b GeneSigDB Published Gene Signatures 1.0 null RPL18 Pathway Commons Protein-Protein Interactions 1.0 null periventricular stratum of Pal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31166 GSE182179_2_v_3_kdsr_human RummaGEO Gene Perturbation Signatures -1.0 null ETFA Pathway Commons Protein-Protein Interactions 1.0 null ZNF384_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null BRD-K93503664 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36997 central nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056498 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_1277_KO_Ptpn2_SRP108032 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.31471 H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null HC-18-NB46_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.219858 abducens nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.09595 REST_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1806 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.579311 Perturb_2236_KO_Malat1_SRP193997 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.13445 GTEX-SN8G-0126-SM-32PLI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.893144 RPS17 Pathway Commons Protein-Protein Interactions 1.0 null EGR1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NC-29-PY58_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.210954 H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null reticular nucleus of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.51572 GTEX-T2IS-2926-SM-32QPO GTEx Tissue Sample Gene Expression Profiles 1.0 1.20292 MCF7_Cimetidine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0157826 Liver hepatocellular carcinoma_LIHC_TCGA-UB-A7ME-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PDK1_knockout_265_GSE42187 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.68763 GTEX-WXYG-0005-SM-3NB3M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3427 SF539 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23665 BD-49-MD69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.447053 ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HSC4 DepMap CRISPR Gene Dependency 1.0 2.09252 ARL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49824 CCT4 Pathway Commons Protein-Protein Interactions 1.0 null SARS-CoV_60Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.7603 UTP3 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Combined oxidative phosphorylation deficiency 9 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.566 IRF1 ENCODE Transcription Factor Targets 1.0 null RPL19 Pathway Commons Protein-Protein Interactions 1.0 null KC-48-OO62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.658339 GTEX-P78B-1026-SM-3NMC4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.892902 MRPS16 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K94306568 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02891 GSE228413_0_v_3_mavs_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WHWD-0005-SM-3LK7D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16554 MAX_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8047-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.42972 PSKH1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00599262 Gamma-hydroxybutyric acidaemia_CNS - Brain - Hippocampus (MMHCC)_GSE2866 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.80862 messa/dx5 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.744 GTEX-XUW1-0005-SM-4BOQ7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26099 MGA::EVX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.1782 REST_PFSK-1_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7014-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WC-09-GD62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.1022 Magnocellular reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32421 POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6688 diencephalon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.303919 GSE210101,GSE210114_5_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2369 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10245 Intracellular organelle lumen COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 SARS-BatSRBD_0Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.63463 Prostate adenocarcinoma_PRAD_TCGA-J4-A67K-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Alisertib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0171044 H2AX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77304 Perturb_1018_Mut_Tspan2_SRP285017 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.50704 PHKA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23861 POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cuneate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.37884 Minor Salivary Gland GTEx Tissue Gene Expression Profiles 2023 1.0 1.02876 GSC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.072 BRD-K51003626 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77819 PMC10279693-41389_2023_477_MOESM3_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_14_MYC Rummagene Transcription Factor Associations 2026 1.0 null GTEX-Q2AG-2826-SM-2HMJQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.34966 CA4 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.92702 GSE210655_1_v_0_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-X4XY-0006-SM-46MV2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50436 BF-49-QA17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.595857 layer 1 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72283 H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RPS8 Pathway Commons Protein-Protein Interactions 1.0 null PIGH LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00673175 GSE158834_0_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null Gingival fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.634 7186_RBMX2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.515516 POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-673 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07386 HADHB Pathway Commons Protein-Protein Interactions 1.0 null BRD-K27881453 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00232 adrenal cortex cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.38603 GSE176008_4_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K05286676 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60306 FB-24-UT80_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.862557 PDX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.4119 BCL3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null embryonic stem feeder layer BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.38502 CRCGN008_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0595 HCFC1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08684 RAD21_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ISL1-27105846-CHIP-SEQ-CPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null POLR2AphosphoS5_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE137144_3_v_0_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EC-62-OE64_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.249042 Perturb_3126_KO_Stra6l_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.23886 ATF3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE81803,GSE81912_0_v_5_fmr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE216273,GSE216292_0_v_8_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_4812_KO_Stat5b_ERP004375 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.15774 NR3C1-23031785-PC12-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null HADHA Pathway Commons Protein-Protein Interactions 1.0 null TD-69-UA90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.257142 GTEX-X4XX-0011-R2A-SM-3P623 GTEx Tissue Sample Gene Expression Profiles 1.0 4.07494 eGFP-HDAC8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CE-95-YX02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.244693 SP4 ENCODE Transcription Factor Targets 1.0 null Anterior cingulate area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76811 H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null dbtrg05mg TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.607 1774_COPG1_P1 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.1678 LARP1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-NPJ7-0011-R9a-SM-2TC5R GTEx Tissue Sample Gene Expression Profiles 1.0 0.855468 RXF393 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.74512 GTEX-RU72-0011-R2A-SM-2TF6O GTEx Tissue Sample Gene Expression Profiles 1.0 0.893409 SIN3A_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUZ12 ENCODE Transcription Factor Targets 1.0 null PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_2_ZZZ3_occupied_genes-ATAC1_bound_genes_ZZZ3 Rummagene Transcription Factor Associations 2026 1.0 null JAK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00491538 PBX3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.7206 AF-00-QK19_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.218244 Retrosplenial area, ventral part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46841 proton-transporting ATP synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.901 Lung squamous cell carcinoma_LUSC_TCGA-18-3412-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HNRNPC Pathway Commons Protein-Protein Interactions 1.0 null SIRT6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TALL-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.06726 BRD-K64890080_BI 2536_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ATAD3B Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26701 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BA-39-OX47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.200872 GSE211744_8_v_4_gdf15_mouse RummaGEO Gene Perturbation Signatures -1.0 null MATR3 Pathway Commons Protein-Protein Interactions 1.0 null STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17023574-TableS1 GeneSigDB Published Gene Signatures 1.0 null CAR-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.9765 mitochondrial ribosome GO Cellular Component Annotations 2023 1.0 null H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10025 Lung adenocarcinoma_LUAD_TCGA-05-5420-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-NPJ8-0011-R3a-SM-2HMIW GTEx Tissue Sample Gene Expression Profiles 1.0 1.34602 BRD-K32235162 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09375 MRPS14 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K21996934 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42542 VSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.9509 CCT3 Pathway Commons Protein-Protein Interactions 1.0 null arcuate nucleus of medulla, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33227 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12260418-pnas.2425984122.sd01.xlsx-TEAD4_6fraction_test_result-Unnamed_3_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K51411441 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23292 NCI-H295R cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.558 Hyperplasia CTD Gene-Disease Associations 1.0 1.55182 NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.840141 SRSF6 Pathway Commons Protein-Protein Interactions 1.0 null SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.947685 GSE195568_3_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null HDAC2_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mitochondrial membrane GO Cellular Component Annotations 2023 1.0 null Perturb_14937_KD_Pnky_SRP053095 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.00021 Perturb_4810_KO_Atp2b4_ERP004375 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.7285 TRIM28_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GM2345 BioGPS Cell Line Gene Expression Profiles -1.0 -1.72359 intracellular non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 BRD-K03116010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00585 EMX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.6241 GF-35-IT27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.780878 Mitochondrial translation termination Reactome Pathways 2024 1.0 null ZEB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4204 EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.5256 Sarcoma_SARC_TCGA-X6-A7W8-01A-21R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HOXC9-25013753-NEUROBLASTOMA BE2-C-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null r7 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55894 GTEX-NPJ8-0011-R6a-SM-2HMKB GTEx Tissue Sample Gene Expression Profiles 1.0 0.865632 GTEX-W5WG-0002-SM-3NMDN GTEx Tissue Sample Gene Expression Profiles 1.0 1.56265 GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06898 K562_Nilotinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0122061 GTEX-NPJ8-1626-SM-2HMIY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.959529 POLR2A_K562_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 19204204-SupplementaryTable5 GeneSigDB Published Gene Signatures 1.0 null Sarcoma_SARC_TCGA-DX-A3M2-01A-21R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-REY6-0326-SM-2TF5A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42445 SAP30 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00543723 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SF268 GDSC Cell Line Gene Expression Profiles -1.0 -1.67458 SCC4 CCLE Cell Line Gene CNV Profiles 1.0 2.55537 MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.3459 SATB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3311 MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EB-67-WB79_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.233354 GTEX-XGQ4-0926-SM-4AT4U GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841474 GC-69-JF03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.392964 Perturb_4719_KO_Trp53_SRP331236 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19139 GSE75209,GSE75212_0_v_1_halofuginone_mouse RummaGEO Drug Perturbation Signatures -1.0 null CEBPD_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K00478394 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02379 NELFE Pathway Commons Protein-Protein Interactions 1.0 null TAF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BW-A5NQ-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K44692299 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23894 GTEX-T2IS-0011-R3A-SM-32QPB GTEx Tissue Sample Gene Expression Profiles 1.0 1.1348 superficial stratum of r8Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25761 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7II-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JB-75-NC66_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.219857 GTEX-TMZS-0006-SM-3DB8G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.987707 PMC3419980-leu201249x6.xls-RUNX1-DHS-1000bp-Unnamed_0_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null IMMT Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-1271 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.896418 CUX1 ENCODE Transcription Factor Targets 1.0 null protein binding GO Molecular Function Annotations 2015 1.0 null AF-00-QK19_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.423584 MIXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.5568 CB-16-SY72_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.24381 JHOM1 CCLE Cell Line Gene CNV Profiles 1.0 2.01424 SIN3A_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF3 ENCODE Transcription Factor Targets 1.0 null GATA4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4273 NR2F2 ENCODE Transcription Factor Targets 1.0 null TFB1M Pathway Commons Protein-Protein Interactions 1.0 null TEAD4_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Retrosplenial area, lateral agranular part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11085 TEAD4 ChEA Transcription Factor Targets 1.0 null H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null cellular component organization or biogenesis GO Biological Process Annotations 2015 1.0 null PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null RBM42 Pathway Commons Protein-Protein Interactions 1.0 null orbital frontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.09981 Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E6-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.55006 MRPL50 Pathway Commons Protein-Protein Interactions 1.0 null intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 BICR 22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.96948 BRD-K15943105 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26925 Brain Lower Grade Glioma_LGG_TCGA-HT-7902-01A-12R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00483 COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.73724 GTEX-RTLS-0226-SM-2TF5E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.941747 POLR3A ENCODE Transcription Factor Targets 1.0 null Plastid ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.531 EP300_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_10350_KD_Zbtb17_ERP119985 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.62607 amygdaloid complex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.47519 RRP12 Pathway Commons Protein-Protein Interactions 1.0 null olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.428 AC-93-LT43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.335108 UF-14-LK87_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.333205 spleen HPA Tissue Protein Expression Profiles -1.0 -1.00836 internal female genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055513 POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Neoplasm Metastasis CTD Gene-Disease Associations 1.0 1.16967 GSE57871_1_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.40973 POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Generalized seizures_Brain_GSE6614 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.15109 XE-69-AT35_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.725125 KDM5B ENCODE Transcription Factor Targets 1.0 null MYOD1 ENCODE Transcription Factor Targets 1.0 null GSE178714_1_v_2_smad2_human RummaGEO Gene Perturbation Signatures 1.0 null H3K18ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null OCT4-18692474-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Perturb_15677_KD_Srsf2_SRP313287 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.7255 GSE149264,GSE149267_2_v_5_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-UPK5-0426-SM-3GAEK GTEx Tissue Sample Gene Expression Profiles 1.0 1.67961 H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-A64V-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFIC_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRPL49 Pathway Commons Protein-Protein Interactions 1.0 null HDAC2_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10359 HSPA1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00694601 amygdaloid complex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.64724 organelle membrane GO Cellular Component Annotations 2015 1.0 null TRMT61A Pathway Commons Protein-Protein Interactions 1.0 null Perturb_11837_KO_Slc45a3_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.226 SERBP1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K96978561 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18505 U-2932 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.832791 BRD-K83949633 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06491 testis_4a HPA Tissue Sample Gene Expression Profiles -1.0 -1.01081 ILF2 Pathway Commons Protein-Protein Interactions 1.0 null central gray of the pons, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.38417 PMC6299095-41389_2018_108_MOESM4_ESM.xlsx-T47D-TRPS1_peak-gene_symbol_TRPS1 Rummagene Transcription Factor Associations 2026 1.0 null FOXP2_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DDRGK1 Pathway Commons Protein-Protein Interactions 1.0 null SW 1990 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15791 JF-84-QZ64_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.53451 GTEX-TML8-1326-SM-4DXTO GTEx Tissue Sample Gene Expression Profiles 1.0 0.847948 SIGMAR1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00490236 HMEL CCLE Cell Line Gene Expression Profiles -1.0 -3.55592 red nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.24382 H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CC-49-CQ25_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.202883 BE-31-XV38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.53286 USP7 Pathway Commons Protein-Protein Interactions 1.0 null GA-59-RW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.43233 c-MYC_KD_GDS2526_112_human_MCF-7 BREAST CANCER cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE111660_4_v_3_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00965 ESYT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18506 RELA ENCODE Transcription Factor Targets 1.0 null SRF_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NAMALWA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.41089 SF3B5 Pathway Commons Protein-Protein Interactions 1.0 null TEAD4 ENCODE Transcription Factor Targets 1.0 null PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_15_MYC Rummagene Transcription Factor Associations 2026 1.0 null GTEX-T2IS-0011-R11A-SM-32QPC GTEx Tissue Sample Gene Expression Profiles 1.0 1.70027 K562_Sorafenib Tosylate_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0147722 OCIAML2 DepMap CRISPR Gene Dependency 1.0 2.10108 BRD-K48029682 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27019 amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.70132 Perturb_14810_KO_Ldah_SRP282425 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 ERF::HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.0139 dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.92036 176_AFG3L2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.535904 H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null vitamin c_homo sapiens_gpl570_gds3635 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_6492_KO_Atrx_SRP323952 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.37322 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null substantia nigra, pars reticulata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.07923 Anteromedial visual area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.33509 phenothrin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29248 SRSF7 Pathway Commons Protein-Protein Interactions 1.0 null BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09581 METTL17 Pathway Commons Protein-Protein Interactions 1.0 null RARB-27405468-CHIP-SEQ-BRAIN-MOUSE ChEA Transcription Factor Targets 2022 1.0 null YY1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-18-MM33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.572221 POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 66.7315 GTEX-Q2AH-1726-SM-3NB2B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.875817 Perturb_16947_OE_Mir181a1_SRP359086 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.05356 stratum pyramidale of rostral CA3 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.886775 BRD-K28274866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51364 GSE93309_2_v_0_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CCDC86 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A1-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null translational termination GO Biological Process Annotations 2015 1.0 null Major Depressive Disorder DisGeNET Gene-Disease Associations 1.0 null Nerve - Tibial GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.840687 NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.940259 Perturb_3091_KO_Gnpda2_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.97324 CD300E LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00513009 GTEX-OXRN-0005-SM-2I5EU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21392 GTEX-QEG4-0126-SM-48TZE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.86126 H3K27ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RWDD2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30437 Perturb_1660_KO_Cd18_SRP376289 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.30669 3086_FIP1L1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.518569 GTEX-WVLH-0011-R11A-SM-3MJFO GTEx Tissue Sample Gene Expression Profiles 1.0 1.2876 10348_ZNF423_ENST00000262383.2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.910277 Perturb_10909_KD_Eif3m_SRP157047 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.12405 BRD-K52148119 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.05281 KDM5A ENCODE Transcription Factor Targets 1.0 null HAX1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00553031 RL7 BioGPS Cell Line Gene Expression Profiles 1.0 0.900717 NCI-H2122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.861829 ESX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7207 external part of AOV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08839 POLR2AphosphoS5_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PIP5KL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00556098 TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K65933652 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3016 EZH2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FA-10-DN36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.243525 GSE146247_0_v_1_sirt7_human RummaGEO Gene Perturbation Signatures -1.0 null GSE79291_1_v_2_streptozotocin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE157594_0_v_4_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null GRWD1 Pathway Commons Protein-Protein Interactions 1.0 null RPL31 Pathway Commons Protein-Protein Interactions 1.0 null LOU-NH91 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10834 IFI16 Pathway Commons Protein-Protein Interactions 1.0 null RBMX Pathway Commons Protein-Protein Interactions 1.0 null Primary motor area, Layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14018 MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Microtome section TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.521 PES1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K69718434 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48516 TRIM28 Pathway Commons Protein-Protein Interactions 1.0 null NCI-H1395 COSMIC Cell Line Gene CNV Profiles 1.0 2.49065 G120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.20257 GSE134375_6_v_2_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null MYC_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null testis_7b HPA Tissue Sample Gene Expression Profiles -1.0 -1.63957 EIF3L Pathway Commons Protein-Protein Interactions 1.0 null HNRNPCL1 Pathway Commons Protein-Protein Interactions 1.0 null pontine nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04428 SB-29-ZH97_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.494031 BACH1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRPS18B Pathway Commons Protein-Protein Interactions 1.0 null ZMIZ1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.95763 GSE183335,GSE183351_1_v_0_lin28b_human RummaGEO Gene Perturbation Signatures 1.0 null microcellular tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.94302 ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K03851221 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22745 BRD-K54964687 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21558 icSARA deltaORF6_48Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.26195 GTEX-S33H-0005-SM-2XCAL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.997308 GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null QE-18-WG07_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.227586 cellular_component GO Cellular Component Annotations 2015 1.0 null TRIM33_knockdown_304_GSE32903 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.7808 NKX6-3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.3671 MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MN-0005-SM-32PLJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38452 MDAMB134VI Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.24617 9910_XRN1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.580818 BRD-K95251122 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08565 NEIL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00631531 MA-06-DJ95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.243026 GTEX-QDVJ-0226-SM-2I5FV GTEx Tissue Sample Gene Expression Profiles 1.0 1.0153 Perturb_3083_KO_Elmo3_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -10.8144 SKHEP1 CCLE Cell Line Gene Expression Profiles -1.0 -1.68868 USF1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF7-22412390-EML-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE147240_3_v_1_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WWYW-0011-R1A-SM-3TW8G GTEx Tissue Sample Gene Expression Profiles 1.0 0.97663 APBB1IP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00660022 H3K4me1_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PAX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.0261 HNRNPK Pathway Commons Protein-Protein Interactions 1.0 null IL17RE LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00795958 EIF2S1 Pathway Commons Protein-Protein Interactions 1.0 null BYSL Pathway Commons Protein-Protein Interactions 1.0 null Kidney Chromophobe_KICH_TCGA-KO-8411-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WOFM-0726-SM-3MJF8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.965376 NFIC ENCODE Transcription Factor Targets 1.0 null EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.484617 PMC6379092-elife-39598-supp2.xlsx-KLF2_target_genes-Mitochondrial_Translation_KLF2 Rummagene Transcription Factor Associations 2026 1.0 null SF295 CCLE Cell Line Gene CNV Profiles -1.0 -1.42118 GTEX-N7MS-2326-SM-2HMLD GTEx Tissue Sample Gene Expression Profiles 1.0 0.965099 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K11247495 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45363 GTEX-X15G-0526-SM-3NMB7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01534 NCI-H1436 COSMIC Cell Line Gene Mutation Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6L9-06A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MA-88-CA03_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.253652 CDK8_knockdown_63_GSE19199 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.26573 HNRNPM Pathway Commons Protein-Protein Interactions 1.0 null RUFY4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00425789 KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PNPLA6 Pathway Commons Protein-Protein Interactions 1.0 null KU1919 CCLE Cell Line Gene CNV Profiles -1.0 -1.34095 REST_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cephalothin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39782 Perturb_16854_KO_Hnrnph1_SRP068520 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.67016 NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02856 RAB22A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45365 GTEX-WFON-0001-SM-3P61W GTEx Tissue Sample Gene Expression Profiles 1.0 1.1493 CRCGN015_MCF10A.WT.HP_24H:J24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.05886 decitabine_homo sapiens_gpl96_gse19610 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EXD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00703611 TRUB2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K98474331 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13733 MCF7_SRT1720 HCl_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0133574 TLX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.9074 BRD-K13627844 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1817 r7 part of parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8553 organelle organization GO Biological Process Annotations 2015 1.0 null H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GABPA_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 AA-46-GL76_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.230232 amygdaloid complex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.863309 protein complex subunit organization GO Biological Process Annotations 2015 1.0 null AE-39-DG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.718695 HSC-4 GDSC Cell Line Gene Expression Profiles 1.0 1.7934 MCF7_XAV-939_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0147253 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15409 liminal reticular formation of m2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07141 BA-84-TD72_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.248979 YY1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F6_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTDH Pathway Commons Protein-Protein Interactions 1.0 null GTEX-P4PQ-0005-SM-2HMKJ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.53676 Basomedial amygdalar nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2694 Prostate adenocarcinoma_PRAD_TCGA-YL-A8HM-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXF2 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-A03898562 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.67252 Perturb_6045_KD_NONO_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 parafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.37949 dexamethasone_homo sapiens_gpl4133_gse42619 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.049011 FF-54-JC89_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.272358 RBBP5 ENCODE Transcription Factor Targets 1.0 null cytoplasmic part LOCATE Curated Protein Localization Annotations 1.0 null H3K4me3_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 mitochondrial translation GO Biological Process Annotations 2015 1.0 null TIMM21 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -2.00674 GSE195568_3_v_10_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PWCY-2226-SM-2S1OP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11708 ZFP42-18358816-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null chr11_73803268_C_T_b38 GTEx eQTL 2025 1.0 1.27462 CCT8 Pathway Commons Protein-Protein Interactions 1.0 null mitochondrial ribosome GO Cellular Component Annotations 2025 1.0 null GSE190384,GSE190386_3_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K37276417 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.239 DA-07-LL18_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.243937 vitamin c_mus musculus_gpl1261_gse37676 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-33-6737-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adrenal cortex disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.352 FNTA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32731 GSE189653,GSE203344_5_v_3_fluoxetine_mouse RummaGEO Drug Perturbation Signatures -1.0 null ATP5A1 Pathway Commons Protein-Protein Interactions 1.0 null large ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.845155 MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT4 MotifMap Predicted Transcription Factor Targets 1.0 null MDA-MB-453 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K22591777 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58819 GTF3C2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Selisistat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162744 MDAMB134VI CCLE Cell Line Gene Expression Profiles 1.0 1.70027 POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-0011-R9a-SM-2YUN5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12549 RRS1 Pathway Commons Protein-Protein Interactions 1.0 null PE01 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03968 MRPL39 Pathway Commons Protein-Protein Interactions 1.0 null r9 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08612 Pancreatic adenocarcinoma_PAAD_TCGA-US-A779-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mammillary body, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.13309 intracellular part LOCATE Curated Protein Localization Annotations 1.0 null GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58006 TA-34-CK62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.225403 RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0319 KDM1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00480368 ZNF709 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50795 ZB-16-BR73_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.348372 GTEX-WHSE-2926-SM-3NMBG GTEx Tissue Sample Gene Expression Profiles 1.0 0.940311 SLR26 CCLE Cell Line Gene CNV Profiles -1.0 -1.51111 GTEX-XBED-0006-SM-47JXO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63456 OCUBM DepMap CRISPR Gene Dependency 1.0 2.18699 XRN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00838074 G3BP2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K17259076 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25041 GSE196104,GSE196106_2_v_0_vsx2_mouse RummaGEO Gene Perturbation Signatures 1.0 null RELA_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TE15 CCLE Cell Line Gene CNV Profiles 1.0 2.09136 GSE148321,GSE169423_2_v_1_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null AB-71-CI37_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.336474 Perturb_13596_KO_Ezh2_SRP314052 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.35464 VZ in subcallosal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05027 TMEM109 Pathway Commons Protein-Protein Interactions 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.16855 GSE143406_1_v_0_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null all GWASdb SNP-Phenotype Associations 1.0 0.030761 Lung adenocarcinoma_LUAD_TCGA-95-7043-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE228106_3_v_1_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K53647637 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.07056 OE-31-YC41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.414268 RFX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null endocrine gland cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.543155 MPG Pathway Commons Protein-Protein Interactions 1.0 null area postrema Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.60722 KCTD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70334 496100641_PCx_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.17235 POLR1A Pathway Commons Protein-Protein Interactions 1.0 null RPS12 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_13212_KO_Lima1_ERP128082 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.1476 cbp_cpb heterozygous mice_GSE30880_328_mouse_Hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null 6845_PSMA5_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.76241 PCK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00615474 inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.18451 NFE2 ENCODE Transcription Factor Targets 1.0 null GSE115542_2_v_1_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null PRRX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.172 NCIH446_LUNG CCLE Cell Line Proteomics 1.0 2.89842 eGFP-GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MALSU1 Pathway Commons Protein-Protein Interactions 1.0 null JC-63-DO70_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.232539 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.984801 GTEX-PVOW-0011-R5A-SM-32PL7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.921889 PLK1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K82814367 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85613 SNU761 CCLE Cell Line Gene Expression Profiles -1.0 -2.48982 ZC3H11A ENCODE Transcription Factor Targets 1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null BRD-K64111129 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20208 CRCGN017_MCF10A.TP53.M_24H:L22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.20133 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VARS2 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_6063_KD_RIF1_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 CL-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.21296 AC-36-SY22_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.464768 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A71B-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GA-28-SS67_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.263067 Fra-1_KO_GDS5078_402_mouse_Lung GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K85627183 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02869 HIST1H4F Pathway Commons Protein-Protein Interactions 1.0 null Accessory facial motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1604 OCI-AML5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.05296 BHLHE40_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE93309_2_v_4_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Hypertension_Adrenal gland_GSE1674 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.2796 GTEX-NPJ8-2626-SM-2D7W2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.838964 GSE151782_6_v_5_aim2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PCCB Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A69E-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.57897 BRD-K10459972 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44221 SKOR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08625 TIMP3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0061404 NCI-H82 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.967796 3537_GRINA_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.528785 BRD-K06459664 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29859 CC-90-EX35_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.514345 GSE147240_3_v_7_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null FA-36-VA24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.363963 AB-18-YN11_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.585336 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K63996931 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24534 RPN1 Pathway Commons Protein-Protein Interactions 1.0 null GRANTA-519 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.929495 salivarygland BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.08428 MTA3 ENCODE Transcription Factor Targets 1.0 null BRD-K50942788 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15795 MRPS6 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZEB1 ENCODE Transcription Factor Targets 1.0 null SYNCRIP Pathway Commons Protein-Protein Interactions 1.0 null MRPS15 Pathway Commons Protein-Protein Interactions 1.0 null PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1c-List_of_1682_genes_differentially_regulated_by_GLI1_FDR_0_1_GLI1 Rummagene Transcription Factor Associations 2026 1.0 null ZNF143 ENCODE Transcription Factor Targets 1.0 null GSE114883_0_v_2_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null Primary visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08562 Perturb_5764_KO_C9orf72_SRP266242 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.47154 H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TSE9-2926-SM-3DB77 GTEx Tissue Sample Gene Expression Profiles 1.0 0.956139 Larval cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.633 Perturb_13761_KO_Hotair_SRP026100 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.27014 17616640-TableS1 GeneSigDB Published Gene Signatures 1.0 null NCI-H2023 COSMIC Cell Line Gene Mutation Profiles 1.0 null disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040455 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null TET2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00743224 GTEX-WOFM-1726-SM-3MJFA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17802 GTEX-QV44-0826-SM-2S1RG GTEx Tissue Sample Gene Expression Profiles 1.0 0.863939 KAT2B ENCODE Transcription Factor Targets 1.0 null GSE158834_10_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null ovary BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.02167 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K95323755 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63425 GSE228106_0_v_4_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.10431 BRD-K43051162 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56696 GSE116810_2_v_0_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null posterior (caudal) superior temporal cortex (area 22c)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.47844 E2F4_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Tazemetostat_10nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0114415 REXO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14387 BRD-K18657361 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09713 H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null UF-27-HS98_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.357027 RNF213 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5277 WBSCR16 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_2235_KO_Irf8_SRP270893 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.54853 Muscular Dystrophy_Muscle - Striated (Skeletal) (MMHCC)_GSE2507 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.707 Ribosomal protein S10 domain InterPro Predicted Protein Domain Annotations 1.0 null orbital frontal cortex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.67126 GTEX-XLM4-0004-SM-4AT5I GTEx Tissue Sample Gene Expression Profiles 1.0 1.80664 BRD-K86964464 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34772 CA2 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.73094 GTEX-PVOW-2526-SM-2XCF7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.880794 FOXM1 ENCODE Transcription Factor Targets 1.0 null YA-92-YO01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.788378 EXOC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06469 GRPEL1 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_8595_KO_Scn1a_SRP311872 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.32018 STRAP Pathway Commons Protein-Protein Interactions 1.0 null GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.863548 NCI-H2595 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.51582 H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF12_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RM2N-1626-SM-2TF5N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2242 VDAC1 Pathway Commons Protein-Protein Interactions 1.0 null RASGRP4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00561036 ETS1-22383799-G1ME-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Perturb_7057_KO_Sod2_ERP107154 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.46662 MCF7_JNJ-7706621_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0156314 GSE216043_10_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null HB-06-WU12_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.257897 POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEXIM1 Pathway Commons Protein-Protein Interactions 1.0 null GSE115542_5_v_4_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null XRCC5 Pathway Commons Protein-Protein Interactions 1.0 null GC-04-UF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.995894 GTEX-SN8G-0326-SM-32PLG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23124 GTEX-QVJO-0011-R9A-SM-2S1QH GTEx Tissue Sample Gene Expression Profiles 1.0 0.920492 RTCB Pathway Commons Protein-Protein Interactions 1.0 null BRD-K43295075 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.37741 r9 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.63942 MDAMB231_BREAST CCLE Cell Line Proteomics 1.0 3.72095 BRD-K42529194 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04345 PML_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LETM1 Pathway Commons Protein-Protein Interactions 1.0 null NSUN2 Pathway Commons Protein-Protein Interactions 1.0 null cellular protein metabolic process GO Biological Process Annotations 2015 1.0 null GSE193258,GSE193259_5_v_12_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null REST_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null QE-79-XO29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.3483 urinary tract TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null R3HCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73772 POU2F2 ENCODE Transcription Factor Targets 1.0 null Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.29688 HD-51-KD29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.558825 RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE217071_3_v_0_ythdf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null TUFM Pathway Commons Protein-Protein Interactions 1.0 null PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_9_GATA1 Rummagene Transcription Factor Associations 2026 1.0 null Main olfactory bulb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13764 Urinary bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.248 HA-E2F1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AA-85-LB25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.302504 outer plexiform zone in extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.977236 Rat-1/BB16 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.665 CFAP126 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23903 periventricular stratum of AStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01092 Mitochondrial large ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.118 BC-54-ON71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.224448 H3K4me1_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CEBPG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.426 BRD-K56650430 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47304 EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAC2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00610463 DA-20-VR86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.874469 ETS1 ENCODE Transcription Factor Targets 1.0 null MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_16446_KO_Kdm5b_SRP291685 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.87315 BRD-K09271653 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09509 GTEX-XOT4-1126-SM-4B66E GTEx Tissue Sample Gene Expression Profiles 1.0 1.21705 Mitochondrial large ribosomal subunit - 2 CM4AI U2OS Cell Map Protein Localization Assemblies 1.0 null DOHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.31471 MZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1919 Perturb_1918_KO_Irf5_SRP186268 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.47459 RPL27 Pathway Commons Protein-Protein Interactions 1.0 null GSE116810_5_v_1_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null NR2F2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216043_11_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null HIST1H1C Pathway Commons Protein-Protein Interactions 1.0 null Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null periventricular stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18616 LoVo cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.912 GTEX-WL46-0011-R11A-SM-3MJFT GTEx Tissue Sample Gene Expression Profiles 1.0 2.0531 HCC1569 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.603732 GSE71468,GSE76476_0_v_3_rbfox1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WFG8-1026-SM-4LVMZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.950139 Perturb_13793_KD_Nup153_SRP108774 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.8694 Lateral reticular nucleus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61101 GTEX-OXRO-1226-SM-48TDL GTEx Tissue Sample Gene Expression Profiles 1.0 1.29782 RELA_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDKN2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00519378 EE-03-SG02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.437287 GSE182680,GSE182683_7_v_9_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null MRPL28 Pathway Commons Protein-Protein Interactions 1.0 null GSE169205_0_v_5_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate part of r8B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0606 RUNX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.289 REST_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QVUS-0011-R3A-SM-3GAFD GTEx Tissue Sample Gene Expression Profiles 1.0 0.980896 PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-PBX3-Unnamed_6_PBX3 Rummagene Transcription Factor Associations 2026 1.0 null medial subdivision of central nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.939017 1441_CDK7_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.632424 POLR2A_K562_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K65445351 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54681 PPP1R10 Pathway Commons Protein-Protein Interactions 1.0 null MAMSTR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00530656 binding GO Molecular Function Annotations 2015 1.0 null MYC-19079543-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K81757081 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01392 TAF1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UTHO-0011-R3A-SM-3GIK8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.99504 NPM1 Pathway Commons Protein-Protein Interactions 1.0 null GSE200352_1_v_8_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null Nucleus of the lateral olfactory tract, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27438 NCI-H441 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.977638 FOSL2 ENCODE Transcription Factor Targets 1.0 null BEND4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02817 H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 2.03565 ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K22280519 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.11206 496100616_FWM_no dementia_TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.01861 PANK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16718 GTEX-N7MS-1626-SM-3LK5F GTEx Tissue Sample Gene Expression Profiles 1.0 0.919934 MYC-19030024-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1 Rummagene Transcription Factor Associations 2026 1.0 null EP300_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.13699 RPS3A Pathway Commons Protein-Protein Interactions 1.0 null CTCF_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD4 ENCODE Transcription Factor Targets 1.0 null GB-06-BA49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.68286 intracellular part GO Cellular Component Annotations 2015 1.0 null COLO684 DepMap CRISPR Gene Dependency 1.0 2.11699 H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03913 IPCEF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0065514 19204204-SupplementaryTable1 GeneSigDB Published Gene Signatures 1.0 null TAF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Retrosplenial area, dorsal part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29516 BRD-K92167240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57594 NSUN4 Pathway Commons Protein-Protein Interactions 1.0 null USP10 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MRPL47 Pathway Commons Protein-Protein Interactions 1.0 null FIP1L1 Pathway Commons Protein-Protein Interactions 1.0 null PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_16943_OE_Mir181a1_SRP359086 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.56765 ETV7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.2073 Anteromedial visual area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65038 GSE193993_4_v_2_sstr2_human RummaGEO Gene Perturbation Signatures 1.0 null YIF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98854 GTEX-WWYW-0011-R5A-SM-3NB3E GTEx Tissue Sample Gene Expression Profiles 1.0 0.977651 Superior frontal gyrus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.629 brain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 substantia nigra reticulata, isthmic part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37721 JUN_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU2F2_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC4017 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11764 H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null pallidal amygdala Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26572 Leukemialymphoblastic(MOLT-4) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.867302 GABP-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null Anterior cingulate area, dorsal part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.86548 cellular process GO Biological Process Annotations 2015 1.0 null LDHAL6B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00547765 chr11_73689645_T_A_b38 GTEx eQTL 2025 1.0 1.71148 SCC-25 GDSC Cell Line Gene Expression Profiles 1.0 1.50067 WT1-20215353-NEPHRON-PROGENITOR-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.80107 GTEX-QVUS-0011-R8A-SM-3GAD7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.865571 UF-14-LK87_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203565 GSE129370_2_v_3_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null K562_AMG-900_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0139171 ESR1-26153859-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null ETS1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.830362 POLR2AphosphoS5_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26425 SMARCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.26156 HNRNPF Pathway Commons Protein-Protein Interactions 1.0 null amygdaloid complex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.18755 biological_process GO Biological Process Annotations 2015 1.0 null A-498 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.57897 H3K4me1_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null REST_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_11016_KO_Ppdpf_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.12747 superficial stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.68288 mitochondrial matrix GO Cellular Component Annotations 2025 1.0 null forebrain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.064726 GTEX-NPJ7-0011-R2a-SM-2I3GF GTEx Tissue Sample Gene Expression Profiles 1.0 1.67217 Sarcoma_SARC_TCGA-K1-A6RV-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE57871_5_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-W5X1-0001-SM-3P61V GTEx Tissue Sample Gene Expression Profiles 1.0 1.35535 DA-07-LL18_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.262134 NCIH2004RT DepMap CRISPR Gene Dependency 1.0 2.17299 brain GTEx Tissue Gene Expression Profiles 1.0 1.54467 GTEX-REY6-0005-SM-2TF54 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.991016 tcf12_21972416_linnegflt3poscd127posly6dneg_bone_marrow_lof_mouse_gpl1261_gse27402 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.075922 GTEX-S4Z8-0006-SM-3K2AQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20092 HB-06-WU12_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.292257 PMC5651844-41467_2017_1173_MOESM7_ESM.xlsx-ZZZ3_ChIP-seq_peaks-Unnamed_7_ZZZ3 Rummagene Transcription Factor Associations 2026 1.0 null A4/FUK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.983306 EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.027375 spinal (inferior) vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16973 Perturb_5542_KO|KD_Fh1|Foxa2_ERP138019 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.37335 EP300_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7260947-pnas.1912355117.sd02.xlsx-Sheet1-1185_common_genes_in_D_E_genes_KD_and_AcAPE1_ACOGG1_G4_AR Rummagene Transcription Factor Associations 2026 1.0 null G130 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10594 H3K4me1_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GC-04-UF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.985863 BCLAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS15A Pathway Commons Protein-Protein Interactions 1.0 null BRD-K78493876 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46651 GTEX-X585-0011-R1B-SM-46MVE GTEx Tissue Sample Gene Expression Profiles 1.0 1.25359 SNRPC Pathway Commons Protein-Protein Interactions 1.0 null B4GALT3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00898636 DARS Pathway Commons Protein-Protein Interactions 1.0 null Mitochondrial membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 basomedial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.69192 VD-76-SO91_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.6048 COR-L23 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.17514 YY1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF2_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114013,GSE114014_0_v_4_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-NPJ7-2826-SM-2I3FU GTEx Tissue Sample Gene Expression Profiles 1.0 1.23291 PSPC1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ETV5::DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.8448 EIF2S2 Pathway Commons Protein-Protein Interactions 1.0 null PMC12260418-pnas.2425984122.sd02.xlsx-TEAD1_6fraction_test_result-Unnamed_3_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null ZSCAN20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65085 Perturb_1798_KO_Hif1a_SRP198677 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.39941 BCLAF1 ENCODE Transcription Factor Targets 1.0 null SLC47A2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00558826 GTEX-REY6-0726-SM-2TF4M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58941 YY1 ChEA Transcription Factor Targets 1.0 null CF-91-JY05_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.2474 DB-41-IH69_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.278403 GTEX-S7SE-2526-SM-2XCDL GTEx Tissue Sample Gene Expression Profiles 1.0 1.49916 MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F1 ChEA Transcription Factor Targets 1.0 null 9886_XAB2_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.22944 PML ENCODE Transcription Factor Targets 1.0 null BRD-K13309514 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21186 primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.39095 Rectum adenocarcinoma_READ_TCGA-DC-4749-01A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE163240_2_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K34009761 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27296 primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.60392 hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08554 Perturb_7087_KO_Phd2/Phd3_SRP156279 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.47812 3054_FECH_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.821803 HNRNPAB Pathway Commons Protein-Protein Interactions 1.0 null Paraflocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39644 H3K36me3_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 16715129-SuppTable4 GeneSigDB Published Gene Signatures 1.0 null REST_PFSK-1_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-49-MD69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.584619 BRD-K36718828 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73197 GSE195568_1_v_10_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null PANC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.9765 GTEX-UTHO-2926-SM-3P5Z9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.55637 Cardiomyopathy_Myocardial tissue_GSE1869 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.69314 WD-62-UB45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207962 DHX9 Pathway Commons Protein-Protein Interactions 1.0 null WD-62-UB45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.252519 Large ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.865 CRCGN014_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7964 GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17757 GTEX-WHSE-0011-R11A-SM-3P5YY GTEx Tissue Sample Gene Expression Profiles 1.0 1.01986 Primary somatosensory area, unassigned Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38463 RELA_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:A19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.49695 GAP43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78409 medial part of r3B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24316 primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.79249 SRF ENCODE Transcription Factor Targets 1.0 null H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null orbital frontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.29627 HC-01-FD24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.560383 AC-28-RT00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.284836 HSPA8 Pathway Commons Protein-Protein Interactions 1.0 null OB-20-LP90_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.363313 cerebellar cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00082 Esophagus - Gastroesophageal Junction GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.47213 Perturb_11167_KO_Tsc1|Pten_SRP156216 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 9.44301 Perturb_11122_KD_Eif3m_SRP162708 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.12405 BRD-K13007223 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08062 FA-63-WI26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.718536 Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K91615044 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4407 GSE135030_3_v_9_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_1124_KO_Myc_SRP168941 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -11.7651 GTEX-T2IS-0011-R5A-SM-32QP4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2107 NKX6-2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.3884 adipose tissue HPA Tissue Gene Expression Profiles -1.0 -1.18275 M14 COSMIC Cell Line Gene Mutation Profiles 1.0 null POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MO-0126-SM-4DM6X GTEx Tissue Sample Gene Expression Profiles 1.0 0.956119 H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.49699 REST_Panc1_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.41286 GTEX-TKQ2-0004-SM-3NMAC GTEx Tissue Sample Gene Expression Profiles 1.0 1.08993 Paraflocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33132 GTEX-RVPU-1526-SM-47JXQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.829497 GSE213588_8_v_5_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null translational elongation GO Biological Process Annotations 2015 1.0 null BRD-K18268126 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05923 CSDE1 Pathway Commons Protein-Protein Interactions 1.0 null HINFP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44602 GTF2I Pathway Commons Protein-Protein Interactions 1.0 null GSE142019,GSE142021_1_v_3_ythdf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ovary HPA Tissue Protein Expression Profiles -1.0 -1.00836 Primary motor area, Layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.48607 CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBM17 Pathway Commons Protein-Protein Interactions 1.0 null PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_ALL-GENE_DBP Rummagene Transcription Factor Associations 2026 1.0 null cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.044316 SARS-BatSRBD_60Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.66509 GSE231648_4_v_5_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null Primary somatosensory area, upper limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.46831 NOP14 Pathway Commons Protein-Protein Interactions 1.0 null GSE115542_2_v_4_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193258,GSE193259_5_v_15_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null BB-44-SX65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.09992 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Retrosplenial area, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15024 intermediate stratum of r10BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40173 TAF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09224 pancreas HPA Tissue Gene Expression Profiles -1.0 -1.46954 GSE183271_4_v_3_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null Organellar small ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.285 NFATC1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE120612_7_v_0_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K11105500 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52007 Mitochondrial metabolism disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.229 GC-46-AX49_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.392005 A549_Sodium Phenylbutyrate_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0143746 CRCGN017_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.37217 Sarcoma_SARC_TCGA-HS-A5N8-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SF1 MotifMap Predicted Transcription Factor Targets 1.0 null Uterus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.932789 GTEX-T5JC-0011-R7A-SM-32PME GTEx Tissue Sample Gene Expression Profiles 1.0 1.16667 Pontine gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13196 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null A549_Busulfan_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0202112 MPP-89 GDSC Cell Line Gene Expression Profiles -1.0 -1.80231 CETP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00765648 BRD-K55414200 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16156 PLCXD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69427 H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IMP3 Pathway Commons Protein-Protein Interactions 1.0 null GSE231648_1_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null CACO-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.986187 Fatty Liver CTD Gene-Disease Associations 1.0 1.21076 Perturb_6008_KD_DDX17_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BRD-K73500518 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3776 UQCRC2 Pathway Commons Protein-Protein Interactions 1.0 null CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PNPT1 Pathway Commons Protein-Protein Interactions 1.0 null CAL 54 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.11913 YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76406 abnormality of the kidney GWASdb SNP-Phenotype Associations 1.0 0.654545 GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42551 TAF1_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K78297750 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.98011 CB-46-FO63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.292386 E2F1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null HSD17B10 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_4367_KO_Peg10_SRP167954 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.69005 hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.47184 STOML2 Pathway Commons Protein-Protein Interactions 1.0 null placenta TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null U2AF2 Pathway Commons Protein-Protein Interactions 1.0 null CA3 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.47023 ZNF716 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4423 H3K79me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE111660_1_v_3_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null MD-86-UW46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.420688 GTEX-UTHO-0011-R11A-SM-3GIJE GTEx Tissue Sample Gene Expression Profiles 1.0 1.7209 RPS2 Pathway Commons Protein-Protein Interactions 1.0 null USF2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POP1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K79887921 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10905 GTEX-X4XX-0011-R11A-SM-46MWQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.06453 GSE70499_3_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null TCP1 Pathway Commons Protein-Protein Interactions 1.0 null SUCLG2 Pathway Commons Protein-Protein Interactions 1.0 null ZBTB7A ENCODE Transcription Factor Targets 1.0 null Perturb_6529_KO_YAP1/WWTR1_SRP212224 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.43214 MCF7_S-Ruxolitinib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0127214 protein complex disassembly GO Biological Process Annotations 2015 1.0 null GTEX-NPJ7-0011-R11A-SM-2I3E8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.928191 A549_Costunolide_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.014415 CDK2AP1 Pathway Commons Protein-Protein Interactions 1.0 null GSE57871_11_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null Perturb_11757_KD_Gatm_SRP330646 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.20014 BRD-K86817746 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09211 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null MBD4 ENCODE Transcription Factor Targets 1.0 null MPZ LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00538694 Perturb_1128_KO_Myc_SRP168941 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.22048 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E4-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRPS17 Pathway Commons Protein-Protein Interactions 1.0 null NDUFS3 Pathway Commons Protein-Protein Interactions 1.0 null PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null TAF7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UE-02-UW61_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208248 pineal_day BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.41491 cellular metabolic process GO Biological Process Annotations 2015 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2990-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE198380_0_v_1_phgdh_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-V955-0005-SM-3P5ZC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34521 BRD-K41272069 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47959 MYOG_myocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K18763924 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.35556 Type 1 diabetes mellitus_Muscle - Striated (Skeletal) (MMHCC)_GSE1659 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.9336 GTEX-XUW1-1526-SM-4BOOY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826215 PMC9038526-mmc1.xlsx-healthy_ctr_vs_LPS-symbols_98_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null WM1799 DepMap CRISPR Gene Dependency 1.0 2.0382 CRCGN015_HEPG2_48H:B11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.54365 5888_NUP155_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.674448 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of FCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15024 RERFLCAI CCLE Cell Line Gene CNV Profiles -1.0 -2.20298 CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X261-0011-R8A-SM-4E3I5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.929038 r7 part of rostral ventromedial reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.98527 MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.04553 Retrosplenial area, ventral part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30667 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3EV-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GA-77-MH38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.23057 PRPF8 Pathway Commons Protein-Protein Interactions 1.0 null Orbital area, lateral part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33821 IMPDH2 Pathway Commons Protein-Protein Interactions 1.0 null RPL4 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-OOBK-2626-SM-2HMKY GTEx Tissue Sample Gene Expression Profiles 1.0 0.877848 Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2ES-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_2229_KO_Rela_ERP122918 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.47468 GSE227634,GSE228381_0_v_7_arid1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-UTHO-0011-R5A-SM-3GIJD GTEx Tissue Sample Gene Expression Profiles 1.0 1.65627 PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_right-y_TFEB_KO_LLOMe_VS_WTLLOMe_UP_TFEB Rummagene Transcription Factor Associations 2026 1.0 null mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.955916 mediodorsal nucleus of thalamus_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.843419 MRPL23 Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE119978,GSE180930_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null HK1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ERLIN2 Pathway Commons Protein-Protein Interactions 1.0 null SLTM Pathway Commons Protein-Protein Interactions 1.0 null HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-P5-A72W-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A23Z-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XMK1-0226-SM-4B65D GTEx Tissue Sample Gene Expression Profiles 1.0 1.17782 BRD-K43192646 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02139 dorsal motor nucleus of the vagus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.940756 COX4I1 Pathway Commons Protein-Protein Interactions 1.0 null Wt1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 68.6613 GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10038 Perturb_6022_KD_HNRNPK_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GT3TKB GDSC Cell Line Gene Expression Profiles -1.0 -1.62813 BRD-K32195266 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22463 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043798 NCI-H2023 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.6815 GTEX-VUSH-0004-SM-3P61T GTEx Tissue Sample Gene Expression Profiles 1.0 2.92804 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUM44PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.02734 KCNA7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0079912 mitochondrial part GO Cellular Component Annotations 2015 1.0 null H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.01076 DHX16 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K81669067 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.83538 SK-MEL-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.33187 OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.86406 H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1181 YY1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K72588970 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38463 SPRING1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12299 EZH2 ENCODE Transcription Factor Targets 1.0 null GSE175787_4_v_10_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null TPSG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08752 GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles -1.0 -3.24062 GTEX-QVJO-0011-R8A-SM-447C7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11224 CUL2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00647221 GTEX-T6MN-0011-R1A-SM-32QOY GTEx Tissue Sample Gene Expression Profiles 1.0 1.40721 EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K26647686 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23353 CAMA-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.69675 cochlear nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.953156 H4K5ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K54606188_(+)-JQ1_HT29_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K56285711 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0424 DDX17 Pathway Commons Protein-Protein Interactions 1.0 null ETV2::DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9312 SRF_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TOP1 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN013_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.38725 GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.99488 GSE144796_3_v_0_linagliptin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSK3B_KD_GDS4305_185_human_U937 acute myeloid leukemia cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE168798_0_v_1_isg15_human RummaGEO Gene Perturbation Signatures -1.0 null AC-36-TL21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.5505 GSE252857_1_v_0_prednisone_mouse RummaGEO Drug Perturbation Signatures -1.0 null RPL15 Pathway Commons Protein-Protein Interactions 1.0 null POU5F1 ENCODE Transcription Factor Targets 1.0 null GSE210885_2_v_6_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mitochondrial intermembrane space protein transporter complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.437 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null metabolic process GO Biological Process Annotations 2015 1.0 null PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Unnamed_1_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null Mitochondrial small ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.285 HSF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0026 HNRNPA3 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN015_HEPG2_48H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.40449 Perturb_1125_KO_Myc_SRP168941 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 MRPS10 Pathway Commons Protein-Protein Interactions 1.0 null PF-382 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.14837 MBLAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46849 TUBA4A Pathway Commons Protein-Protein Interactions 1.0 null NCI-H2110 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09408 IGFN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00695815 6793_PRPF31_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.809114 posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.095 NH-12 GDSC Cell Line Gene Expression Profiles 1.0 1.48551 primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.45133 BRD-A89471191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14456 CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null DTX3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00475446 POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJMC-1026-SM-4IHKN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.943561 POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null adrenal gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.150973 RUNX1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null BRD-K40894545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44809 brain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056668 TBP_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNRNPU Pathway Commons Protein-Protein Interactions 1.0 null GSE147943_4_v_6_cited2_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null EXOSC6 Pathway Commons Protein-Protein Interactions 1.0 null MALME-3M cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.52 superior olivary complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00491 SETDB1_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K47438870 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51508 FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCE-4 COSMIC Cell Line Gene CNV Profiles 1.0 2.49065 MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NUDT17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60289 heart_5b HPA Tissue Sample Gene Expression Profiles 1.0 0.979726 GSE151612_4_v_8_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00785 KS-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.28831 GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62094 Primary somatosensory area, unassigned, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.82351 FECH LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0049704 Perturb_11798_KO_Entpd8_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.52141 sublayer 6b of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03524 GTEX-X5EB-2626-SM-4E3HZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07273 BRD-K87479423 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.93485 BRD-K41412255 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23668 SARS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12177 HNRNPH1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XUJ4-0004-SM-4BOQE GTEx Tissue Sample Gene Expression Profiles 1.0 1.16835 GSE186005_1_v_2_klf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2AphosphoS5_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MOGS Pathway Commons Protein-Protein Interactions 1.0 null BRD-K94742710 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40128 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A5R2-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RIBC2 Pathway Commons Protein-Protein Interactions 1.0 null MEOX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7255 Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-06A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF140 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 52.3788 BB-77-QQ71_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.392596 GSE138818_1_v_0_nanog_mouse RummaGEO Gene Perturbation Signatures 1.0 null AIMP1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-TKQ1-0526-SM-4DXTG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858844 POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA3-24758297-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null hippocampus (hippocampal formation)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07701 LIN7C Pathway Commons Protein-Protein Interactions 1.0 null GTEX-U8T8-0326-SM-3DB93 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27268 ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null captopril_mus musculus_gpl1261_gds3683 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.0521 POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null TE15 CCLE Cell Line Gene Expression Profiles 1.0 2.22027 GSE213588_8_v_12_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.49631 GSE211425_1_v_0_mettl3_human RummaGEO Gene Perturbation Signatures -1.0 null NCL Pathway Commons Protein-Protein Interactions 1.0 null Perturb_13618_KD_Hnrnpa1_SRP339273 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.94729 COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.852845 BRD-K54467766 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35976 6801_PRPF4_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.78965 GTEX-P4QT-0226-SM-3LK68 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.862516 striatum_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06803 primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.06388 intermediate stratum of Pal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00938 primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09328 YY1_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF15 Pathway Commons Protein-Protein Interactions 1.0 null DA-58-LZ09_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.408761 dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.926276 BRD-K45092891 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38541 Brain Lower Grade Glioma_LGG_TCGA-HW-7486-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_1129_KO_Myc_SRP168941 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -11.8449 BD-60-DR81_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.225678 FE-10-KQ78_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.524275 CRCGN015_HEPG2_48H:B19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.28164 parasolitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.24985 Infertility, Male CTD Gene-Disease Associations 1.0 1.53283 H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MRPL22 Pathway Commons Protein-Protein Interactions 1.0 null NOLC1 Pathway Commons Protein-Protein Interactions 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2778-01A-02R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NACAD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11875 IZ in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00163 mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.49556 BRD-K93460493 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89327 PMC8948659-ADVS-9-2104491-s013.xlsx-Sheet1-Supplemental_Table_9_related_to_Figure_7_Differential_genes_highly_correlated_with_TP53_deletion_in_H929_cells_by_RNA-seq_TP53 Rummagene Transcription Factor Associations 2026 1.0 null GSE190384,GSE190386_6_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null SLIRP Pathway Commons Protein-Protein Interactions 1.0 null GSE166004_1_v_0_pld1_mouse RummaGEO Gene Perturbation Signatures 1.0 null urinary system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null dorsal motor nucleus of the vagus (vagal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.886769 DMS-53 COSMIC Cell Line Gene CNV Profiles 1.0 2.49065 PABPC3 Pathway Commons Protein-Protein Interactions 1.0 null POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FGFBP1 Pathway Commons Protein-Protein Interactions 1.0 null GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE82032_3_v_1_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null E2F6_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.01728 peripeduncular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43648 SRF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.947 MEX3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22238 YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-0226-SM-3DB84 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11757 Perturb_13233_OE_Rnaseh1_SRP056871 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.07848 Perturb_5541_KO|KD_Fh1|Foxa2_ERP138019 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.54049 IQGAP1 Pathway Commons Protein-Protein Interactions 1.0 null KA-75-LP02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.232331 ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.57958 ARID3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01588 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.839105 GTEX-WEY5-1126-SM-4LMIE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.889104 PECAPJ34CLONEC12 CCLE Cell Line Gene CNV Profiles -1.0 -1.75914 EIF2S3 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K43025624 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.82478 EC-62-OE64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.634349 LU-165 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-WI4N-1026-SM-3LK7N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20516 H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null THRAP3 Pathway Commons Protein-Protein Interactions 1.0 null GSE130383_2_v_0_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null SF3B2 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null skmel30 HPA Cell Line Gene Expression Profiles 1.0 2.10794 Anterior cingulate area, dorsal part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45146 CRCGN011_HEPG2_24H:J04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5046 membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA Rummagene Transcription Factor Associations 2026 1.0 null BRD-K51061297 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70537 9886_XAB2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.775329 ventrolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.4537 urinary system disease GWASdb SNP-Disease Associations 1.0 0.190317 SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PUS1 Pathway Commons Protein-Protein Interactions 1.0 null intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.18825 H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HOXB8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.418 GSE205729,GSE205731_2_v_0_tazemetostat_human RummaGEO Drug Perturbation Signatures -1.0 null GSE158834_7_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null POP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22866 MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Edema CTD Gene-Disease Associations 1.0 1.22916 NZM3 DepMap CRISPR Gene Dependency 1.0 2.03823 Mitochondrial ribosome CM4AI U2OS Cell Map Protein Localization Assemblies 1.0 null Primary somatosensory area, trunk, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14018 MALME3M CCLE Cell Line Gene CNV Profiles -1.0 -1.45921 GABPA-29892750-EML-MOUSE-BONEMARROW ChEA Transcription Factor Targets 2022 1.0 null organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.044976 CNOT3 ChEA Transcription Factor Targets 1.0 null CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCM3 Pathway Commons Protein-Protein Interactions 1.0 null NAT10 Pathway Commons Protein-Protein Interactions 1.0 null AA-86-YY62_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237504 MRM1 Pathway Commons Protein-Protein Interactions 1.0 null supraoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.884868 Bladder Urothelial Carcinoma_BLCA_TCGA-R3-A69X-01A-22R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WRHK-1726-SM-3MJFK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.998828 K562_Resminostat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.014591 NIPSNAP1 Pathway Commons Protein-Protein Interactions 1.0 null GSE147943_5_v_1_cited2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Pulmonary emphysema DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.299 BRD-K35693854 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89973 CRCGN012_HEPG2_24H:J20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.20548 PL4 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.86013 EMX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.4133 SGPL1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X5EB-0004-SM-46MWA GTEx Tissue Sample Gene Expression Profiles 1.0 1.36122 EFTUD2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K73463737 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34558 BRD-K96945047 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16323 POLR2A_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5886-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K48835953 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04808 IA-27-CK10_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.206938 H3K4me1_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K63354944 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08556 Leukemia_chronicMyelogenousK-562 BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.5108 MYC_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null U87MG CCLE Cell Line Gene CNV Profiles -1.0 -1.59902 TRIM28 ChEA Transcription Factor Targets 1.0 null AE-95-UU45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.02701 GTEX-OHPM-2626-SM-33HC5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06833 NPRL2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00441252 GTEX-XQ3S-1726-SM-4BOOD GTEx Tissue Sample Gene Expression Profiles 1.0 1.31586 CRCGN015_HEPG2_48H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.22002 WC-09-GD62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.16125 cellular macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-TKQ1-0006-SM-33HBI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3833 GR-ST GDSC Cell Line Gene Expression Profiles 1.0 2.62834 GSPT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0063073 Brain Lower Grade Glioma_LGG_TCGA-QH-A65X-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.909923 GSE101546_2_v_1_setdb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_7965_OE_MPL_SRP287959 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.7646 Primary somatosensory area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07928 orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.86788 ZC3H4 Pathway Commons Protein-Protein Interactions 1.0 null GSE196104,GSE196106_3_v_1_vsx2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.4049 ANAPC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11679 SMAD4-21741376-EPCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NALM-6 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.6539 GTEX-S7SE-0011-R10A-SM-2XCDF GTEx Tissue Sample Gene Expression Profiles 1.0 0.838922 BRD-K78015078 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7598 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TMZS-0001-SM-3P61Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.12534 BD-04-NG34_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.513346 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13242 GTEX-OHPM-2126-SM-3LK75 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.861415 TCF7 ChEA Transcription Factor Targets 1.0 null Obesity-related traits GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.539794 BRD-K54533560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02519 NCI-H2342 COSMIC Cell Line Gene Mutation Profiles 1.0 null TEAD4_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.40238 SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.944511 496100554_FWM_no dementia_no TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.10381 H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null layer 5 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11902 BRD-K99074976 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.2308 BRD-K37680172 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78451 layer 4 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00609 DDX1 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_14935_KO_Polr2a_SRP181107 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -16.212 H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.67445 ERAL1 Pathway Commons Protein-Protein Interactions 1.0 null PMC10830421-41589_2023_1452_MOESM5_ESM.xlsx-HEK293T_MAX-Tg_tissues-Unnamed_0_MAX Rummagene Transcription Factor Associations 2026 1.0 null H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YW-1826-SM-2YUN2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.882445 H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Clevudine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0175108 BRD-K12202458 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28051 ZBTB33_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE171837_3_v_2_bortezomib_mouse RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SF3B4 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null outer CP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.879337 CRCGN010_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9601 15260889-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null Posterior parietal association areas, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24316 hippocampus (hippocampal formation)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.9837 ZSCAN16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 54.2685 BRD-K67390061 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15168 YY1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF384_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K48987279 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45184 GSE211215_1_v_0_pemetrexed_human RummaGEO Drug Perturbation Signatures -1.0 null NRP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15017 reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.05363 paracentral lobule, posterior part, right, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.48398 AA-58-FJ71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.238386 BRD-A56909893 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.82783 BRD-K28640166 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3302 PMC3470785-NIHMS377161-supplement-4.pdf-3-JRK_JRK Rummagene Transcription Factor Associations 2026 1.0 null FLI1_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mitochondrial translation Reactome Pathways 2014 1.0 null THBS1 Pathway Commons Protein-Protein Interactions 1.0 null PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim29_KD-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null KARPAS299 CCLE Cell Line Gene Expression Profiles -1.0 -1.59642 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A69H-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLRMT Pathway Commons Protein-Protein Interactions 1.0 null PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim22_KD-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE193258,GSE193259_2_v_12_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 CTCF_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K80848948 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14358 Perturb_8512_KO_Bmal1_ERP009958 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.17735 hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.13241 CA4 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.45737 Primary somatosensory area, upper limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.94534 MZ in rostral midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.66681 H3K4me1_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ISCA1 Pathway Commons Protein-Protein Interactions 1.0 null ATP5B Pathway Commons Protein-Protein Interactions 1.0 null head TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70A-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TRIM28-19339689-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null COLO 857 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.48982 GTEX-SN8G-0006-SM-32PLD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.880475 GSE69869_0_v_1_panobinostat_mouse RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A7D7-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SRSF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25776 BC-25-VR48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.329386 Mitochondrial matrix COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 ARH-77 COSMIC Cell Line Gene Mutation Profiles 1.0 null HSPD1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K45665532 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16963 COLO 205 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.997323 AE-19-BK71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.27462 EWSR1 Pathway Commons Protein-Protein Interactions 1.0 null GCM2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.638 USF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 4691_LSM2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.557707 BRD-A50287893 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15762 Brain Lower Grade Glioma_LGG_TCGA-VM-A8CF-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K14ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null OB-06-WW76_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.229142 H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ATP5F1 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_3077_KO_Dct_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.38693 Perturb_13298_OE_Pik3ca_SRP173204 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.61527 FC-85-OX77_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.259348 KYM1_SOFT_TISSUE CCLE Cell Line Proteomics 1.0 2.09367 DC-47-KV62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.992144 GSE42805,GSE42811_1_v_0_cocaine_mouse RummaGEO Drug Perturbation Signatures 1.0 null CB-32-EI69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.557354 FD-59-TC81_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.376024 GTPBP10 Pathway Commons Protein-Protein Interactions 1.0 null PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.995988 H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VPS37C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33419 Perturb_15139_KD_Myt1l_SRP062495 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.34341 Primary somatosensory area, upper limb, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1435 PMPCA Pathway Commons Protein-Protein Interactions 1.0 null Perturb_4521_KO_Mapk1/Mapk3_SRP281895 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.22355 SRP9 Pathway Commons Protein-Protein Interactions 1.0 null REC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.30806 SYK_druginhibition_290_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.52258 RPL26 Pathway Commons Protein-Protein Interactions 1.0 null HMGB2 Pathway Commons Protein-Protein Interactions 1.0 null ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETV6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2088 RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tRNA (m2G10) methyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.653 Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J2-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FUBP3 Pathway Commons Protein-Protein Interactions 1.0 null PUF60 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K20030272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36629 BRD-K57035236 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.371 RPS4X Pathway Commons Protein-Protein Interactions 1.0 null GSE158320,GSE183351_2_v_3_lin28b_human RummaGEO Gene Perturbation Signatures -1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.08951 PABIR1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00540716 testis_7d HPA Tissue Sample Gene Expression Profiles -1.0 -1.86825 NKX6-1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.9651 SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23786 GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.79013 GSE125219,GSE125221_3_v_8_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null OV-56 COSMIC Cell Line Gene Mutation Profiles 1.0 null MDA MB435 BioGPS Cell Line Gene Expression Profiles 1.0 0.860768 USF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PGAM5 Pathway Commons Protein-Protein Interactions 1.0 null Organellar ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.46 EEF1B2 Pathway Commons Protein-Protein Interactions 1.0 null CDC42 Pathway Commons Protein-Protein Interactions 1.0 null UBC Pathway Commons Protein-Protein Interactions 1.0 null CRIP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02006 Perturb_1275_KO_Ptpn2_SRP108032 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.41933 MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K92928918 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81021 KB-17-DU74_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.227319 A549_FLLL32_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0128162 H3K23me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Somatosensory areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00748 H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2F4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLI1_megakaryocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKMEL30 CCLE Cell Line Gene Expression Profiles 1.0 1.55081 BD-61-OO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.434614 MCF7_Fasudil_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.015216 C81-61 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.912 MYCN-28898695-NB1643-HUMAN-NERVE-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null KCNK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00646122 Zic3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.1051 GTEX-P78B-0005-SM-2I5GM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.972035 Viral cardiomyopathy_Myocardial tissue_GSE4172 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.39648 adenoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.259477 GSE193258,GSE193259_5_v_13_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null RPS26 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K62511698 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12367 GSE172146_2_v_1_mettl1_human RummaGEO Gene Perturbation Signatures 1.0 null GA-04-JM33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208345 496100608_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.04306 MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K95160020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21373 Perturb_11015_KO_Ppbp_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.37344 baclofen-2036 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K84514454 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.11924 EBF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOXC8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.6641 EOMES ChEA Transcription Factor Targets 1.0 null core of nucleus accumbens Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20878 DIS3 Pathway Commons Protein-Protein Interactions 1.0 null SARS-CoV_36Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.24528 SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null JHUEM3 CCLE Cell Line Gene CNV Profiles 1.0 1.56919 GSE209582_1_v_2_chloroquine_human RummaGEO Drug Perturbation Signatures -1.0 null WC-16-IR43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.589008 inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22546 15260889-TableS2a GeneSigDB Published Gene Signatures 1.0 null primary metabolic process GO Biological Process Annotations 2015 1.0 null basal nucleus of meynert, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.854655 PML_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWCY-0826-SM-48TCR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01874 STAT3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ICT1 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_216_KO_Gpd2_SRP361070 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 9.97832 Lung squamous cell carcinoma_LUSC_TCGA-33-4582-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X8HC-0526-SM-4E3JA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38377 REST_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell part GO Cellular Component Annotations 2015 1.0 null GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25208 DRG1 Pathway Commons Protein-Protein Interactions 1.0 null LSM3 Pathway Commons Protein-Protein Interactions 1.0 null GABPA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6363-01A-21R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.29228 RH41_SOFT_TISSUE CCLE Cell Line Proteomics 1.0 3.44167 CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K61020385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07936 Perturb_18604_KO_Zfp708_SRP186171 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.14436 primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.63078 GTEX-U3ZN-0002-SM-3NMDF GTEx Tissue Sample Gene Expression Profiles 1.0 0.905792 CAMP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00578395 GSE112763,GSE112767_4_v_1_dgcr8_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K07895476 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.07344 BRD-K67902591 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25296 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 5462_NAPA_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.508391 GTEX-N7MT-0011-R7a-SM-2I3FZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.926158 MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.840141 BRD-A02799884 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10352 Perturb_6324_KD_AdipoR1_SRP377446 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.72564 BRD-K45056520 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63289 CIITA-25753668-RAJI-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE95688_1_v_0_glutathione_mouse RummaGEO Drug Perturbation Signatures 1.0 null LRPPRC Pathway Commons Protein-Protein Interactions 1.0 null GSE84148,GSE96938_0_v_2_nrros_mouse RummaGEO Gene Perturbation Signatures -1.0 null LD-69-ZV56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.617315 OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27223 TE9 CCLE Cell Line Gene CNV Profiles -1.0 -1.44069 H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2F6 ENCODE Transcription Factor Targets 1.0 null FOSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20497 ZNF79 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74822 AE-14-NN26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.504417 ME-54-JY76_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.333976 GSE193993_5_v_3_sstr2_human RummaGEO Gene Perturbation Signatures -1.0 null esophagus HPA Tissue Gene Expression Profiles 1.0 1.04603 9592_UNC45A_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.548318 ZNF384_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RPL23A Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4794 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 SLC22A23 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00545943 SREK1 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5117-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 20_ABCB10_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.73521 FOSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55781 BCL7C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00750336 Perturb_5289_KD_Rpl10a_SRP064202 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.3288 pontine nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.53649 FLI1 ChEA Transcription Factor Targets 1.0 null GSE178714_5_v_2_smad2_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null organic substance metabolic process GO Biological Process Annotations 2015 1.0 null SIN3A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EIF3C Pathway Commons Protein-Protein Interactions 1.0 null CHCHD2P9 Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNRPD2 Pathway Commons Protein-Protein Interactions 1.0 null GSE252857_1_v_0_klf15_mouse RummaGEO Gene Perturbation Signatures -1.0 null COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.57252 Distal tubular epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.507 cerebellar cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.59774 LS123 CCLE Cell Line Gene CNV Profiles 1.0 1.36803 GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.93287 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WOFM-0005-SM-3MJF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54796 H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HNRNPUL2 Pathway Commons Protein-Protein Interactions 1.0 null MAFK ENCODE Transcription Factor Targets 1.0 null NUPR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32865 translational initiation GO Biological Process Annotations 2015 1.0 null K562_Ivosidenib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0194011 Retrosplenial area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24878 E2F4_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SE-81-RI20_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.350336 POLR2A_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMEM45A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00568373 FOXM1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ribosome COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIGLEC14 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00590356 cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.75152 SISO Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.90854 GSE189653,GSE203344_4_v_3_fluoxetine_mouse RummaGEO Drug Perturbation Signatures -1.0 null AA-58-FJ71_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.248151 KLF5-25053715-YYC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null DBT Pathway Commons Protein-Protein Interactions 1.0 null GSE123372,GSE123373_1_v_2_mecp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE171837_0_v_2_bortezomib_mouse RummaGEO Drug Perturbation Signatures 1.0 null VA-06-DB75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.229481 SLC2A4RG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53115 Perturb_8630_KO_Shank2_SRP368084 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.40053 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51K-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r6 part of rostral ventromedial reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31646 GSE135350_3_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null mantle zone of r7BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12338 FOXA1 ENCODE Transcription Factor Targets 1.0 null CCT7 Pathway Commons Protein-Protein Interactions 1.0 null BB-77-QQ71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.809274 sublayer 6b of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22129 polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01093 AB-12-IS33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.348853 SLC25A6 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K05837079 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31087 SARS-CoV MA15_Day4-PFU-10^5_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.88218 GSE213611_1_v_0_nuf2_human RummaGEO Gene Perturbation Signatures -1.0 null PD-70-VS77_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.07336 GTEX-XPT6-0006-SM-4B66Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51555 BRD-K55053106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14431 Perturb_3102_KO_N4bp3_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.8823 NFYB ENCODE Transcription Factor Targets 1.0 null Lingula (I), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47189 GTEX-PLZ6-1326-SM-3NB24 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.938727 AA-22-UI44_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.703672 AA-23-FM46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.525228 KARS Pathway Commons Protein-Protein Interactions 1.0 null FOXP2 ENCODE Transcription Factor Targets 1.0 null GTEX-T6MO-1926-SM-32QOJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.871497 ELK1::HOXA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1407 GSE133505_5_v_4_myf6_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE101527_0_v_1_smad4_mouse RummaGEO Gene Perturbation Signatures 1.0 null ESRRA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DF-00-BU08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.09222 eRF1 methyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.647 Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2BK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Stomach Smooth Muscle Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.75498 CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN011_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.8723 SNU761 CCLE Cell Line Gene CNV Profiles -1.0 -3.14406 GTEX-TSE9-0326-SM-3DB82 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38036 H2AK5ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-VJYA-0426-SM-3GIJK GTEx Tissue Sample Gene Expression Profiles 1.0 1.32976 JE-72-KV75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.230661 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null organelle lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.06219 hMPV_72Hour_18234263_GSE8961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -0.918062 POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-52-7810-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLDIP3 Pathway Commons Protein-Protein Interactions 1.0 null H3K36me3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K51927648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04676 HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null cytoplasm LOCATE Predicted Protein Localization Annotations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5367-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC-18940864-HL60-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K34677894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02747 Organellar large ribosomal subunit COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null UBTF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SF295 DepMap CRISPR Gene Dependency 1.0 2.01465 H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K14451397 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47726 GTEX-POMQ-0006-SM-33HBY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45997 POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM4A ENCODE Transcription Factor Targets 1.0 null SK-MEL-28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.09205 striatum_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.54495 GTEX-R55F-1226-SM-2TF59 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25502 PABPC1 Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100642_PCx_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.06591 BRD-A24524033 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.00933 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XQ3S-0006-SM-4BOQ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58066 H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K99034771 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75679 BRD-K73608149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73848 GTEX-XOTO-0006-SM-4B64T GTEx Tissue Sample Gene Expression Profiles -1.0 -2.09559 ACADVL Pathway Commons Protein-Protein Interactions 1.0 null GSE125782_3_v_2_glutamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE165548_2_v_8_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null mitochondrial part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.075062 GSE153867_6_v_3_olaparib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K79me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A-CA-04-2009(H1N1)_48Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.79185 GSE149123,GSE149128_2_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null TBP ENCODE Transcription Factor Targets 1.0 null striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.83415 reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 SNU-449 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.705 Rectum adenocarcinoma_READ_TCGA-AG-3725-11A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NUDT21 Pathway Commons Protein-Protein Interactions 1.0 null HOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.1388 BRD-K14470344 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15312 BRD-K13782363 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04638 H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE169571_5_v_1_dexamethasone_mouse RummaGEO Drug Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.904987 SURF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16154 inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.56033 SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.39192 anteromedial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.11334 SW 982 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.971009 OTX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.2922 r5 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27732 POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DDX28 Pathway Commons Protein-Protein Interactions 1.0 null RPSA Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XV7Q-1526-SM-4BRWB GTEx Tissue Sample Gene Expression Profiles 1.0 1.99848 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K32063762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.90097 GSE44157,GSE44163_3_v_0_nr6a1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SIX5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null single-organism biosynthetic process GO Biological Process Annotations 2015 1.0 null TBL1XR1 ENCODE Transcription Factor Targets 1.0 null GABPA_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PLA2G2D LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0041606 SARS-BatSRBD_96Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.23096 MYC-19030024-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K35717699 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33171 NME4 Pathway Commons Protein-Protein Interactions 1.0 null A498 CCLE Cell Line Gene CNV Profiles -1.0 -1.33168 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AA-22-UI44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.601632 Adrenal cortical adenoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.039 SNU466 CCLE Cell Line Gene Expression Profiles -1.0 -1.7823 BACH1 ENCODE Transcription Factor Targets 1.0 null MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytochrome-c oxidase deficiency disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.298 GATA3_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRDM1 JASPAR Predicted Transcription Factor Targets 1.0 null GATA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.2562 IZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25954 fallopiantube_5a HPA Tissue Sample Gene Expression Profiles 1.0 2.20962 cerebellar cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.1133 Lung squamous cell carcinoma_LUSC_TCGA-77-8009-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A74H-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P78B-0526-SM-2I5F7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.906146 TMEM43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23585 CRCGN015_MCF10A.TP53.M_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.3191 GSE153757,GSE153758_1_v_3_ftsj1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_HEPG2_48H:L04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.65326 SOX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.3095 caudal subdivision of medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.852021 CRCGN015_MCF10A.TP53.M_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.05825 POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null daudi HPA Cell Line Gene Expression Profiles 1.0 1.08458 superficial stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27916 Perturb_2379_KD_Cdk8_SRP292215 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.68671 GTEX-U3ZM-0226-SM-4DXTA GTEx Tissue Sample Gene Expression Profiles 1.0 1.07601 FD-20-OG99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.257951 HSC4 CCLE Cell Line Gene CNV Profiles 1.0 1.78412 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13801 NOP16 Pathway Commons Protein-Protein Interactions 1.0 null SLC25A1 Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X261-0011-R11A-SM-4E3JY GTEx Tissue Sample Gene Expression Profiles 1.0 2.06695 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null adrenal cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.180119 interpositus (intermediate) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.986779 BRD-K28814368 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7403 PDGFRB_knockdown_114_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.88659 GSE227592_6_v_1_adar_human RummaGEO Gene Perturbation Signatures 1.0 null EN2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.7472 GABPA_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PARS2 Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HI-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBM3 Pathway Commons Protein-Protein Interactions 1.0 null GSE216274,GSE216292_4_v_2_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null ZNF582 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.8157 ELK4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SH3BGRL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01396 H3K79me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KRTCAP3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00599372 zona incerta, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00834 testis_7e HPA Tissue Sample Gene Expression Profiles -1.0 -1.14848 EP300_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.4986 Perturb_3705_OE_Lin28b_SRP319706 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.78195 GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles -1.0 -2.73399 CE-37-XI06_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.202738 HE-43-BS90_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.242583 Perturb_10807_KO_Xbp1_SRP197108 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.70707 NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null Perturb_15253_KI_E2f1_SRP217336 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.58663 GSE142684_4_v_7_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null EA-84-SC49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.217762 STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K54934070 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15021 H3K79me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A57M-01A-51R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF12_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K01362004 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05829 ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WB-48-EF24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.440938 SNU840 CCLE Cell Line Gene Expression Profiles -1.0 -1.77993 BRD-K50497551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18611 GTEX-WRHK-0005-SM-3MJF5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07472 Perturb_11740_KO_Trp53_SRP221563 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.79432 MTFMT Pathway Commons Protein-Protein Interactions 1.0 null NDUFAF3 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K41347678 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03233 granular layer of caudal dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.29407 GTEX-T6MN-0011-R9A-SM-32QOZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.46413 GSE137325_2_v_0_copanlisib_human RummaGEO Drug Perturbation Signatures -1.0 null GM2493 BioGPS Cell Line Gene Expression Profiles -1.0 -0.844674 GSE176008_4_v_1_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE209898,GSE209899_0_v_1_flcn_human RummaGEO Gene Perturbation Signatures -1.0 null GATA3 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K24047785 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36789 FASTKD2 Pathway Commons Protein-Protein Interactions 1.0 null MJ DepMap CRISPR Gene Dependency 1.0 2.12545 GSE180200,GSE180201_15_v_1_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null MYC_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATP1B2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00631853 GTEX-P44H-0326-SM-2XCES GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16099 HNRNPH3 Pathway Commons Protein-Protein Interactions 1.0 null OB olfactory fiber layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.73848 COLO-818 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.830025 17533364-TableS3 GeneSigDB Published Gene Signatures 1.0 null POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null chr11_73787888_T_G_b38 GTEx eQTL 2025 1.0 3.94712 1976_CWF19L2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.685516 MCF7_Prednisone_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0124015 MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cystic Fibrosis_Pancreas_GSE769 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.40891 GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MICU1 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN014_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.56305 MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null EOMES-20176728-TROPHOBLAST STEM CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RAD21_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCL3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 614_ATF7_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.511423 Perturb_6089_KD_YBX3_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE193258,GSE193259_5_v_1_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null cerebellar cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.76729 Perturb_3481_KO_Ccn1_SRP304010 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.35565 GATA3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Major depressive disorder GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.669897 Disease Progression HuGE Navigator Gene-Phenotype Associations 1.0 null DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.10782 PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null GSE211744_7_v_1_gdf15_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_16771_KO_Snai2|Snai3_SRP065478 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.5223 MAX_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cell type benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.196779 K562_AMG-900_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0153933 Perturb_9261_KO_Ifng_ERP010742 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.52913 SLC25A4 Pathway Commons Protein-Protein Interactions 1.0 null occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.88042 PD-70-VS77_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.239275 SARS2 Pathway Commons Protein-Protein Interactions 1.0 null AA-49-BD04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.317929 CAMA1 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.689921 AKT1_knockout_213_GSE39699 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.80421 GTEX-T5JW-0003-SM-3NMAD GTEx Tissue Sample Gene Expression Profiles 1.0 1.01725 CAKI-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.85144 DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.3091 Perturb_11426_KD_PRMT1_SRP357238 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.85057 CRCGN016_MCF10A.TP53.M_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5756 BRD-K19327124 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12872 hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08404 ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRPS7 Pathway Commons Protein-Protein Interactions 1.0 null FE-06-GR60_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.21578 COV362 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.97037 GSE158834_11_v_8_palm_human RummaGEO Gene Perturbation Signatures -1.0 null PMC3296722-pone.0032481.s009.xlsx-Sheet_1_MSC_vs_references-Gene_Symbol_MSC Rummagene Transcription Factor Associations 2026 1.0 null MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K86897283 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09188 ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE169590_6_v_1_rptor_human RummaGEO Gene Perturbation Signatures -1.0 null TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K34423419 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38179 HNRNPDL Pathway Commons Protein-Protein Interactions 1.0 null IZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.55961 GTEX-T5JC-0011-R9A-SM-32PLV GTEx Tissue Sample Gene Expression Profiles 1.0 1.02118 BRD-K36848506 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59092 LY86 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00553413 BRD-K75990394 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39856 OC-71-BZ81_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.287547 BRD-K63410075 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17872 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZFP91 Pathway Commons Protein-Protein Interactions 1.0 null YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K41684304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08202 amygdaloid complex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01366 SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IARS Pathway Commons Protein-Protein Interactions 1.0 null H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE165122_2_v_3_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE169152_3_v_6_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null CA3 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.10081 SSBP1 Pathway Commons Protein-Protein Interactions 1.0 null mitochondrial gene expression GO Biological Process Annotations 2025 1.0 null Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06978 RBM27 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XYKS-0005-SM-4BRUD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04569 GTEX-P44H-1126-SM-48TBU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17267 u TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.183 BRD-K87180723 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17836 Rectum adenocarcinoma_READ_TCGA-DC-5869-01A-01R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 BRD-K33497830 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09785 Perturb_12884_KO_Ccnk_SRP127682 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.50489 ALDH1B1 Pathway Commons Protein-Protein Interactions 1.0 null KA-29-AB08_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.18871 diethylstilbestrol_mus musculus_gpl6887_gse37969 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FOSL2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05547 CRCGN015_HEPG2_48H:L19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.99178 POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_3128_KO_Synm_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.91305 OXA1L Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XPT6-0001-SM-4B64G GTEx Tissue Sample Gene Expression Profiles 1.0 1.29804 GSE210682_2_v_1_methadone_human RummaGEO Drug Perturbation Signatures 1.0 null 15843827-TableS11 GeneSigDB Published Gene Signatures 1.0 null mantle zone of r3BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24316 RSL1D1 Pathway Commons Protein-Protein Interactions 1.0 null H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEL4-0726-SM-3GIJ5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.03125 AD-51-FB60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.220518 Primary somatosensory area, unassigned, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14186 GSE57871_8_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null HIST1H1A Pathway Commons Protein-Protein Interactions 1.0 null BRD-K45190659 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14562 RPS24 Pathway Commons Protein-Protein Interactions 1.0 null Posterolateral visual area, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09964 Primary somatosensory area, unassigned, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04117 GTEX-R55E-0011-R9A-SM-2TC6C GTEx Tissue Sample Gene Expression Profiles 1.0 1.39524 CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.87809 Kidney Diseases CTD Gene-Disease Associations 1.0 1.28919 BRD-K97867712 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67042 LHX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.9098 Perturb_5340_KO_Dnmt1/Dnmt3a/Dnmt3b_SRP337936 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.04016 Perturb_4811_KO_Mapk1_ERP004375 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.57254 H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_4324_KO_Btg1_SRP325922 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.39473 KYSE-520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.977638 Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IJ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TEAD4-22529382-TROPHECTODERM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null 20003503-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null PF-39-DY68_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.209887 primary auditory cortex (core)_25 pcw_F_12948 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.24403 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.09868 Prostate adenocarcinoma_PRAD_TCGA-KK-A7B0-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPM-1826-SM-2YUNF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.8651 MARCKS Pathway Commons Protein-Protein Interactions 1.0 null FOSL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_5996_KD_BCLAF1_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GC-07-UO80_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.259551 QA-07-KC40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.2907 CRCGN017_MCF10A.TP53.M_24H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.16125 H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FB-39-CW59_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.408854 GSE110524_2_v_5_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K27823380 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18861 WT1 ChEA Transcription Factor Targets 1.0 null organism form TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12772 BACH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46259 CRCGN012_HEPG2_24H:P07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0279 cellular macromolecule biosynthetic process GO Biological Process Annotations 2015 1.0 null GTEX-TKQ1-0426-SM-4DXT4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.957435 PITX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5828 AE-39-DG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.730274 RAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.3571 AKAP8 Pathway Commons Protein-Protein Interactions 1.0 null umbilical artery TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null cellular component organization GO Biological Process Annotations 2015 1.0 null BRD-K70343553 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55399 SLFN14 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00749305 Perturb_11790_KO_Cd109_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.48796 MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYOD1_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40859 BRD-K44492160 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03187 GSE142588_2_v_1_cinobufagin_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.0864 SP4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE125007,GSE125008_10_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K85392247 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00176 GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.998308 GSE155305_2_v_1_ifitm3_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K95913506 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26929 USF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WZTO-0011-R1B-SM-3NMAR GTEx Tissue Sample Gene Expression Profiles 1.0 1.26219 PMC12697907-ADVS-12-e07451-s002.xlsx-ST4F_MR-pan-cancer-out-Unnamed_1_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null single-organism cellular process GO Biological Process Annotations 2015 1.0 null EPHA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00441159 non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 CCT5 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-X585-0426-SM-4E3JZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.908455 GTEX-OIZI-0226-SM-2XCEE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.88687 SPSB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08068 dorsolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.96991 CRCGN009_HEPG2_24H:H03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.38277 F36P CCLE Cell Line Gene Expression Profiles 1.0 1.45039 GTEX-NPJ8-1526-SM-2D7VU GTEx Tissue Sample Gene Expression Profiles 1.0 0.852312 GTEX-RU72-0006-SM-2TF65 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.917072 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JM-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH146_LUNG CCLE Cell Line Proteomics 1.0 2.23471 CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NL4W-0011-R9a-SM-2I3G1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.37165 CRCGN016_MCF10A.WT.HP_24H:A22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.91235 striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.37514 Primary somatosensory area, lower limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01769 G-402 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00477 MDAMB134VI CCLE Cell Line Gene CNV Profiles 1.0 3.26799 H3K4me1_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MMAB Pathway Commons Protein-Protein Interactions 1.0 null mitochondrion LOCATE Curated Protein Localization Annotations 1.0 null Sarcoma_SARC_TCGA-DX-A8BZ-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZFP42 ChEA Transcription Factor Targets 1.0 null RPL3 Pathway Commons Protein-Protein Interactions 1.0 null SJSA1 CCLE Cell Line Gene CNV Profiles -1.0 -1.97304 K562_SRT2104_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0148668 MCF7_Thiotepa_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0147856 ALYREF Pathway Commons Protein-Protein Interactions 1.0 null PE-68-QD35_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203133 paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06276 NC-52-HX69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.269222 GSE211286_1_v_3_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null SLR26 CCLE Cell Line Gene Expression Profiles -1.0 -2.80777 CD177 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00532179 Perturb_17247_KD_Brd2_SRP201499 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.39044 BRD-K97064059 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4096 BRD-K92446632 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74564 SIX5 ENCODE Transcription Factor Targets 1.0 null ZBTB33 ENCODE Transcription Factor Targets 1.0 null GSE163862_1_v_3_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K57497543 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.43921 CTCF_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 1971_CWC15_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.800612 PMC9314667-Table_1.xlsx-Regulons-MITF_MITF Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QDT8-0011-R2A-SM-32PKQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.892855 GTEX-N7MS-0011-R2a-SM-2HML6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.33566 Organelle inner membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 Staf MotifMap Predicted Transcription Factor Targets 1.0 null pparg_21068720_macrophage_c57bl6_lof_mouse_gpl1261_gds4370 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.823348 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SYNE1 Pathway Commons Protein-Protein Interactions 1.0 null TRIM29 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K92950328 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30449 GSE118766_2_v_0_ifng_mouse RummaGEO Gene Perturbation Signatures 1.0 null MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null membrane-enclosed lumen COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 SRY JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4286 HS274T CCLE Cell Line Gene Expression Profiles -1.0 -1.95052 GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78169 TRIM28-19339689-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null STAT3 ENCODE Transcription Factor Targets 1.0 null ETV3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0765 H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WVLH-0006-SM-3MJF7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25046 KMS12BM CCLE Cell Line Gene Expression Profiles 1.0 1.48506 GSE151782_1_v_0_aim2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SPTA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00696482 MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.91127 GSE137144_3_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K72253829 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29993 BRD-K44004565 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03195 KLHDC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96372 C4BPB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00601792 ARID3A ENCODE Transcription Factor Targets 1.0 null Retinitis Pigmentosa_Retina_GSE128 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.36715 FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null superficial stratum of r8BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.09836 GSE244710_3_v_2_srsf1_human RummaGEO Gene Perturbation Signatures 1.0 null CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary somatosensory area, trunk, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07928 GTEX-X8HC-0006-SM-46MV6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58703 GSE225218_9_v_3_abcb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Rectum adenocarcinoma_READ_TCGA-DC-5337-01A-01R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Electron transfer flavoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.775 MRPL10 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-X4XX-2926-SM-3NMB1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.36782 r6 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.67291 Lung squamous cell carcinoma_LUSC_TCGA-85-8277-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null midbrain reticular formation Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.997652 Perturb_10364_KD_Setd2_SRP184682 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.83554 BRD-K94247332 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07197 posteroventral (inferior) parietal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.862147 MRPL3 Pathway Commons Protein-Protein Interactions 1.0 null COLO-800 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.30606 BJAB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.836034 496100562_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.22512 sublayer 6b of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11736 A-CA-04-2009(H1N1)_36Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.49499 GSE211744_7_v_4_gdf15_mouse RummaGEO Gene Perturbation Signatures -1.0 null HCC366 CCLE Cell Line Gene CNV Profiles 1.0 1.44364 ATP5L Pathway Commons Protein-Protein Interactions 1.0 null GSE110440_1_v_0_rad21_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K01351858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21468 SSX2IP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15412 BRD-K52838863 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10323 BRD-K87712055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01207 ME-31-RM40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.269343 ANKRD33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09697 SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.64555 CBS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34917 PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null DHX30 Pathway Commons Protein-Protein Interactions 1.0 null HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45515 BRD-K88135858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25765 EMG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30457 496100390_PCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.16268 CTCF_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IC-05-AW29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20239 YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Busulfan_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0144103 MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE94849_7_v_5_pinometostat_human RummaGEO Drug Perturbation Signatures -1.0 null MRRF Pathway Commons Protein-Protein Interactions 1.0 null TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND-26020271-SMOOTH-MUSCLE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-OHPN-0011-R9A-SM-4DXUH GTEx Tissue Sample Gene Expression Profiles 1.0 1.69346 DRAM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31034 blood GTEx Tissue Gene Expression Profiles -1.0 -1.01199 GTEX-U3ZH-0002-SM-3NMDD GTEx Tissue Sample Gene Expression Profiles 1.0 1.21482 MYBBP1A Pathway Commons Protein-Protein Interactions 1.0 null AA-18-GQ83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.258277 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193258,GSE193259_9_v_15_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null mitochondrial gene expression GO Biological Process Annotations 2023 1.0 null PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30866 GSE158834_12_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE235066_7_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-H9-A6BY-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MNX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7402 PMC6347838-13046_2019_1042_MOESM3_ESM.xls-PRDM16_group_peak_anno-Gene_PRDM16 Rummagene Transcription Factor Associations 2026 1.0 null ADCK3 Pathway Commons Protein-Protein Interactions 1.0 null ECSCR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00557357 SNRPA1 Pathway Commons Protein-Protein Interactions 1.0 null GSE125403_3_v_6_venetoclax_human RummaGEO Drug Perturbation Signatures 1.0 null HDAC2_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.09447 PMC6366065-13075_2019_1816_MOESM1_ESM.xlsx-DOD_Skin_imputed_log2_median_ce-Name_PIN1 Rummagene Transcription Factor Associations 2026 1.0 null MDAMB468_BREAST CCLE Cell Line Proteomics 1.0 2.2741 rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.964432 MRPL27 Pathway Commons Protein-Protein Interactions 1.0 null Mitochondrial ribosomal protein L48 InterPro Predicted Protein Domain Annotations 1.0 null GTEX-T8EM-0626-SM-4DM62 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.871033 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A5KF-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null valproic acid_mus musculus_gpl6885_gse41020 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MRPS25 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-X4XX-0011-R4B-SM-46MWL GTEx Tissue Sample Gene Expression Profiles 1.0 1.48089 Sarcoma_SARC_TCGA-MB-A5Y8-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteromedial visual area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1369 C6orf203 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-X585-0011-R5A-SM-46MVI GTEx Tissue Sample Gene Expression Profiles 1.0 1.9731 Bladder TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.82101 K562_Barasertib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0149336 intermediate part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17342 irf8_00000000_splenic_cd11bplusgrdash1_hdash2b_gen_background_lof_mouse_gpl6887_gse39228 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.066456 spinal trigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.965063 TCF12_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Creatinine dbGAP Gene-Trait Associations 1.0 0.123321 BRD-K28349636 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03986 ONECUT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.3997 BRD-K57242481 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09396 HEC6_ENDOMETRIUM CCLE Cell Line Proteomics 1.0 2.79431 BRD-K44177046 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04325 HOXA3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.4099 H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_13980_KD_Ago2_ERP133202 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 HSF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.2474 NCI-H727 GDSC Cell Line Gene Expression Profiles 1.0 1.68924 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054821 PHB Pathway Commons Protein-Protein Interactions 1.0 null BRD-A21524347 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17661 ATF2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU387 CCLE Cell Line Gene CNV Profiles 1.0 1.48763 CEBPB_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SBC5_LUNG CCLE Cell Line Proteomics 1.0 2.62238 H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null r5 part of ventral lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03469 PBX3 ENCODE Transcription Factor Targets 1.0 null superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13341 PRPF31 Pathway Commons Protein-Protein Interactions 1.0 null SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.93465 SW684 COSMIC Cell Line Gene Mutation Profiles 1.0 null NC-01-ET52_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208366 GTEX-S32W-2226-SM-2XCAY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.873831 BRD-K43603649 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07273 ribonucleoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.095811 Lung squamous cell carcinoma_LUSC_TCGA-77-7337-01A-21R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HC-74-HM63_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.343747 layer 3 of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0777 pallidal islands of Calleja Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03621 KASUMI-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.757 GSE226355,GSE226357_3_v_4_ybx1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QVUS-0006-SM-3GAE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37636 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J6-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE186633_2_v_0_chd1_human RummaGEO Gene Perturbation Signatures -1.0 null urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051594 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Perturb_13559_KD_Kdm1a_SRP105108 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.78703 MRPL44 Pathway Commons Protein-Protein Interactions 1.0 null GSE199660_1_v_3_secretin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Orbital area, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10439 FA-92-JL46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.2304 ZMIZ1 ENCODE Transcription Factor Targets 1.0 null BRD-K19020285 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.28497 PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1 Rummagene Transcription Factor Associations 2026 1.0 null GSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.5161 RPL27A Pathway Commons Protein-Protein Interactions 1.0 null 1148_CACTIN_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.559922 BRD-K24020784 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05617 IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null EIF3F Pathway Commons Protein-Protein Interactions 1.0 null TA-34-CK62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.386436 H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K56778317 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0056 NOTO JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.8984 RPL5 Pathway Commons Protein-Protein Interactions 1.0 null GSE231648_1_v_2_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null UTP14A Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A6E7-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K10288935 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38222 JD-58-MV19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.291853 GTEX-WFG7-0001-SM-3P61S GTEx Tissue Sample Gene Expression Profiles 1.0 1.04611 EGR1-23403033-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null chr11_73827653_T_G_b38 GTEx eQTL 2025 1.0 1.35322 EPLC272H CCLE Cell Line Gene CNV Profiles 1.0 1.68336 GSE166783_8_v_2_tp53_human RummaGEO Gene Perturbation Signatures 1.0 null PB-40-YB26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.250909 CLPX Pathway Commons Protein-Protein Interactions 1.0 null BRD-K03191078 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07033 SW684 GDSC Cell Line Gene Expression Profiles -1.0 -1.51341 Posterolateral visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.59798 TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_10962_KO_Arl10_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.92643 BARX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.5239 HS 255.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.60353 PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_1_ZZZ3_ChIP-seq_peaks-Nearest_TSS_ZZZ3 Rummagene Transcription Factor Associations 2026 1.0 null MTG1 Pathway Commons Protein-Protein Interactions 1.0 null RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SF-0006-SM-3K2B6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4909 primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.54195 CPSF1 Pathway Commons Protein-Protein Interactions 1.0 null VSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.4968 STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nobox_18509161_newborn_ovary_lof_mouse_gpl1261_gds3254 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.443522 GTEX-QEG5-0826-SM-2I5GF GTEx Tissue Sample Gene Expression Profiles 1.0 1.06939 IZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.54298 Brain Lower Grade Glioma_LGG_TCGA-S9-A6WD-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ribosome COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 MRPL55 Pathway Commons Protein-Protein Interactions 1.0 null membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 ETS1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TFB2M Pathway Commons Protein-Protein Interactions 1.0 null layer 1 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.553 TAF1_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -2.07576 8190_SMU1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.552252 Lung adenocarcinoma_LUAD_TCGA-64-1677-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHD2 ENCODE Transcription Factor Targets 1.0 null CRCGN016_MCF10A.TP53.M_24H:A22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.8128 DAUDI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.85759 HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRPL15 Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5Q6-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UF-14-LK87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.236632 primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.846769 Uterine Cervical Neoplasms CTD Gene-Disease Associations 1.0 1.11606 GD-46-OD81_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.213338 GTEX-P44H-0426-SM-2XCEZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.965128 YME1L1 Pathway Commons Protein-Protein Interactions 1.0 null MOV10 Pathway Commons Protein-Protein Interactions 1.0 null REST_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NDUFA9 Pathway Commons Protein-Protein Interactions 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV7-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r8 part of inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.82373 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R7-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null mantle zone of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1768 H3K27ac_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null E2F4_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCLAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FC-22-VC55_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.576539 AE-43-UJ94_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.277266 CRCGN017_MCF10A.WT.HP_24H:A05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.23509 hsa-miR-96 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 mitochondrial matrix COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 EGR1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GLUD1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ChIP_MYC_19079543 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null HSC39 DepMap CRISPR Gene Dependency 1.0 2.10622 REG1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00510432 SLC25A11 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN014_HEPG2_3H:D13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.10465 GTEX-T5JC-0005-SM-4DM7B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31726 PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D4REFED48h_750_AR--Gene_Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null SF268 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.861829 PMC3485261-pone.0046600.s008.docx-0-JAZAG_TGFB1__SIGNALING_VIA__SMAD4_UP_SMAD4 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K99416393 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27355 BRD-K26273412 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.97083 GTEX-X585-0011-R2B-SM-46MVF GTEx Tissue Sample Gene Expression Profiles 1.0 2.22586 chr11_73780340_A_G_b38 GTEx eQTL 2025 1.0 1.06037 intermediate stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35927 H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE233679_5_v_3_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null AFG3L2 Pathway Commons Protein-Protein Interactions 1.0 null A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc_3Hour_None_GSE43204 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.53963 PRPF3 Pathway Commons Protein-Protein Interactions 1.0 null CNOT3-19339689-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null LD-69-ZV56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.990627 IC-80-CT90_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.435307 non-membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null Field CA3, stratum lucidum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23035 KP2_PANCREAS CCLE Cell Line Proteomics 1.0 3.36788 BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -2.08341 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3458-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE95685_2_v_5_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null BRD-K81586131 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.08731 REST_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null gigantocellular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1922 AKAP1 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_6353_KO_Smn_SRP253847 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.54189 MRPS23 Pathway Commons Protein-Protein Interactions 1.0 null Peroxisomal importomer complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.847 Anterior cingulate area, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.3182 intermediate stratum of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08386 SW756 DepMap CRISPR Gene Dependency 1.0 2.03417 Perturb_4233_KO_Pnky_SRP187847 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -18.2596 EE-03-SG02_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.231104 GTEX-QEG4-0006-SM-2I5FY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46358 striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.84478 TMC8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00546808 USF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null r8 part of the paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.09836 POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100504_TCx_probable Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.66622 r9 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.26614 GSC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13399 GSE121824,GSE121826_0_v_8_scaf8_human RummaGEO Gene Perturbation Signatures -1.0 null colon_8b HPA Tissue Sample Gene Expression Profiles 1.0 0.834032 ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CPS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29646 NELFE_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null HDAC6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE255432_4_v_0_imeglimin_mouse RummaGEO Drug Perturbation Signatures 1.0 null ELK4 ENCODE Transcription Factor Targets 1.0 null GTEX-WYJK-0005-SM-3NMA1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03313 BRD-K30628727 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.00177 BRD-K14383477 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46362 Lung squamous cell carcinoma_LUSC_TCGA-66-2766-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.26812 FOXA2 ENCODE Transcription Factor Targets 1.0 null Perturb_14688_KO_Pax6_ERP022747 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.01073 EP300_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE146687_2_v_6_eribulin_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC-22102868-BL-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null ERR2 (ESRRB) MotifMap Predicted Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-MN-A4N1-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RD-90-OY66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.216934 HOP-92 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08667 MYC ENCODE Transcription Factor Targets 1.0 null GABPA_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWO3-1026-SM-2I5F2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.887076 SLC25A10 Pathway Commons Protein-Protein Interactions 1.0 null Sarcoma_SARC_TCGA-HB-A3L4-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JUND_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_2019_KO_Parp1_SRP243891 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 13.4389 mitochondrial ribosome GO Cellular Component Annotations 2015 1.0 null GSE112760,GSE112767_1_v_5_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE237040_2_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null vestibular nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.837689 Brain Lower Grade Glioma_LGG_TCGA-HT-7693-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BC-26-LE04_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.241389 BRD-K88472400 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23041 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEWO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.60418 TCF3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K73695595 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16152 gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.332117 PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12 Rummagene Transcription Factor Associations 2026 1.0 null macromolecular complex GO Cellular Component Annotations 2015 1.0 null GTEX-WFG8-0006-SM-3GIKS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43968 HS 895.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.31707 Mitochondrial translation elongation Reactome Pathways 2014 1.0 null ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_13762_KO_Hotair_SRP026100 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.4746 9656_USP39_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.674448 LF-94-HB11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.232422 AD-16-HL96_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.34485 medial mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.895999 TCF3 ENCODE Transcription Factor Targets 1.0 null GTEX-QEL4-2126-SM-447AE GTEx Tissue Sample Gene Expression Profiles 1.0 1.09181 GTEX-QLQW-0005-SM-2S1RA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.922433 PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_12_GATA1 Rummagene Transcription Factor Associations 2026 1.0 null GSE201309_4_v_6_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_2232_KO_Rela_ERP122918 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.0284 H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null single-organism metabolic process GO Biological Process Annotations 2015 1.0 null TCF12_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PTCD1 Pathway Commons Protein-Protein Interactions 1.0 null SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Weight Gain CTD Gene-Disease Associations 1.0 1.07589 GSE213588_10_v_4_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null bonemarrow BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.0861 H3K27ac_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EIF2B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02515 POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null STAT3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mitochondrial matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.217511 CEBPB ENCODE Transcription Factor Targets 1.0 null CCT6A Pathway Commons Protein-Protein Interactions 1.0 null GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23436 DDX27 Pathway Commons Protein-Protein Interactions 1.0 null SCC-25 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.36065 DDX50 Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5973-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K52416366 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28628 GTEX-X4XX-0011-R8B-SM-46MWM GTEx Tissue Sample Gene Expression Profiles 1.0 1.14952 GTEX-UPK5-2026-SM-4JBIM GTEx Tissue Sample Gene Expression Profiles 1.0 0.935217 ALX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.7382 ADNP-35650610-MESC-MOUSE-STEM-AUTISM ChEA Transcription Factor Targets 2022 1.0 null GTEX-U8T8-1226-SM-4E3IH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61309 GSE210101,GSE210114_5_v_10_urod_human RummaGEO Gene Perturbation Signatures -1.0 null abnormality of the upper urinary tract GWASdb SNP-Phenotype Associations 1.0 0.135087 H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T2IS-0011-R2A-SM-32QPF GTEx Tissue Sample Gene Expression Profiles 1.0 1.0993 GTEX-S7SE-0011-R6A-SM-2XCD9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06813 PB-18-HD85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.52664 MRPS23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60288 mediodorsal nucleus of thalamus_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.03307 FSCN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00514555 BRD-K56738235 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07389 GTEX-XLM4-2926-SM-4AT59 GTEx Tissue Sample Gene Expression Profiles 1.0 0.910383 BRD-K56595246 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6133 Artery - Aorta GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.680493 MDM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67034 CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.85492 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SNRNP200 Pathway Commons Protein-Protein Interactions 1.0 null MCCC2 Pathway Commons Protein-Protein Interactions 1.0 null FBXO22 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00493245 MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_10_ZZZ3_ChIP-seq_in_shNT-Nearest_TSS_ZZZ3 Rummagene Transcription Factor Associations 2026 1.0 null NZOV9 DepMap CRISPR Gene Dependency 1.0 2.18439 TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K49656278 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13166 GTEX-S32W-0126-SM-4AD61 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0002 BRD-K20451745 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75914 organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 PRRX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.2216 Prostatic Diseases CTD Gene-Disease Associations 1.0 1.36791 stratum pyramidale of caudal CA3 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.898446 GSE145990_1_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null LC-12-VN85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.628352 H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null infection GAD High Level Gene-Disease Associations 1.0 0.293278 VRK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33865 H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_5888_KD_Ift88_SRP188845 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.65903 BC-54-ON71_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.730046 19351829-SuppTableC GeneSigDB Published Gene Signatures 1.0 null RUNX2-24655370-MC3T3E1-MOUSE-BONE ChEA Transcription Factor Targets 2022 1.0 null K562_Celecoxib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149448 FF-06-MO73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.249105 H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BF-10-IO69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.271337 Perturb_4474_OE_Smn_SRP258674 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.84006 GSE151612_0_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.34536 SF3B1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-RVPU-2326-SM-2TF6R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50595 BRD-K21955645 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44859 VAX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.3534 BRD-K01577807 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10758 BRD-K26163290 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5119 K562_Triamcinolone Acetonide_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0113728 H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A23K-01A-11R-A16R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01054 Perturb_15752_KO_Ezh2_SRP096837 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 NOP9 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN012_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.15486 SCC-25 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.15761 BRD-K89089981 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05057 Perturb_9525_Mut_Thra_SRP334033 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 PPP2R2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0059025 GSE57871_1_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_17711_KD_ZFP281_SRP068749 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.40522 DMS53 CCLE Cell Line Gene CNV Profiles 1.0 1.33606 VAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.0153 YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.839105 TCF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CIRBP Pathway Commons Protein-Protein Interactions 1.0 null RETSAT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00732093 SYT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00783239 GTEX-P4QS-1826-SM-2S1NI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.840628 POLR2AphosphoS5_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RUNX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6978 BRD-K43911180 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59801 H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Stomach GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.669606 SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU4F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.3695 NCI-H2023 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.861829 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4115-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_12077_KD_Tardbp_SRP170083 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.5657 PMC12585103-pbio.3003444.s013.xlsx-List_of_genes_for_GO_analysis-List_of_genes_undergoing_significant_MXE_upon_PRMT5_KD_under_hypoxia_AR Rummagene Transcription Factor Associations 2026 1.0 null WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lymph node HPA Tissue Protein Expression Profiles -1.0 -1.00836 central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GTEX-X5EB-2226-SM-46MW4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.843178 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04255 PMC5095001-oncotarget-07-36293-s002.xlsx-Table_S2-Table_S2_MYCN-correlated_genes_and_their_correlations_with_other_transcription_factors_MYCN Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SIRT6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ETS1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCLAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle LOCATE Curated Protein Localization Annotations 1.0 null Perturb_6176_KO_Opn1lw/Ep300_SRP201904 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.32398 BRD-K30462643 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56724 BRD-K08927194 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39154 GSE213588_8_v_3_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null LMX1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.0699 germ layer TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-UPIC-0002-SM-3NMDC GTEx Tissue Sample Gene Expression Profiles 1.0 0.95076 7338_RNF113A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.560674 GSE57871_8_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null CA2 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.34874 USF1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WYJK-0426-SM-3NM9G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.92883 GSE246461,GSE246463_5_v_0_mecp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K05001008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74274 Blood TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me1_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null DC-51-WE27_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.239453 RPS3 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QXCU-0626-SM-2TC69 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41615 GTEX-WWYW-3026-SM-3NB36 GTEx Tissue Sample Gene Expression Profiles 1.0 1.942 GSE228106_3_v_2_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MRPS22 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K29143088 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42283 TCF3_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein metabolic process GO Biological Process Annotations 2015 1.0 null Primary somatosensory area, unassigned, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35043 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7097-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell part LOCATE Curated Protein Localization Annotations 1.0 null BRD-K98153780 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52248 CHD7_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ribosome GO Cellular Component Annotations 2015 1.0 null H3K9me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MRPS35 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K76812105 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27593 Brain Lower Grade Glioma_LGG_TCGA-FG-A60L-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OHPL-0006-SM-3MJHB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57808 r1 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52691 BRD-K34009110 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52631 POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATP5H Pathway Commons Protein-Protein Interactions 1.0 null Perturb_14039_KO_Dnmt1/Dnmt3a/Dnmt3b/Creb1_SRP337936 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -10.4754 POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX ENCODE Transcription Factor Targets 1.0 null Perturb_13047_KO_YAP1/WWTR1_SRP212218 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -19.3979 MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45515 SNRPD1 Pathway Commons Protein-Protein Interactions 1.0 null APH1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00561987 QA-07-KC40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.459437 PMC8755441-mmc3.xlsx-IRF7-Up-stat1-hela_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null agranular insular cortex (area Iag) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.4998 CRCGN017_MCF10A.WT.HP_24H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.32825 posteroventral (inferior) parietal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.830867 MYOG ENCODE Transcription Factor Targets 1.0 null DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16206 u87 HPA Cell Line Gene Expression Profiles -1.0 -2.17243 GSE232223_1_v_0_letmd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S32W-2426-SM-2XCAT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08218 POU5F1-18692474-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null sublayer 6a of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32239 GSE186707_1_v_0_hdac4_mouse RummaGEO Gene Perturbation Signatures 1.0 null NFATC3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.0035 GSE95077_1_v_2_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null 496100484_FWM_no dementia_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.4598 GTEX-PWOO-0006-SM-2I3E3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13541 BRD-K81131499 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38411 Anterior cingulate area, dorsal part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07298 H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOXM1-26100407-CHIP-SEQ-HEK293-FLP-IN-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BF-97-LS55_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.767926 H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null osteoblasts BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.94807 preoptic area TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.741327 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K96745500 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13478 8666_TAF5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.677928 JUND ENCODE Transcription Factor Targets 1.0 null ALL-SIL Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.56233 H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null USF1_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null LHX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.1503 GSE211744_2_v_1_gdf15_mouse RummaGEO Gene Perturbation Signatures -1.0 null WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PML_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular component disassembly GO Biological Process Annotations 2015 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IG-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventromedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.951831 GSE223287,GSE223290_2_v_4_braf_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE129186,GSE129223_0_v_1_aicda_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_10248_KO_Ipr/Ldlr_SRP150735 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.67538 AR ChEA Transcription Factor Targets 1.0 null H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC10641274-mmc2.xlsx-FOXK1_Untreated-ENSEMBL_FOXK1 Rummagene Transcription Factor Associations 2026 1.0 null Paragigantocellular reticular nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03469 Lung squamous cell carcinoma_LUSC_TCGA-85-A53L-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CCNT2 ENCODE Transcription Factor Targets 1.0 null GTEX-QESD-0006-SM-2I5G6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.85088 GEMIN5 Pathway Commons Protein-Protein Interactions 1.0 null ZNF384 ENCODE Transcription Factor Targets 1.0 null DLX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43325 624 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.06445 HOXD4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.2556 H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZC3H11A Pathway Commons Protein-Protein Interactions 1.0 null USF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RALY Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null metabolic GAD High Level Gene-Disease Associations 1.0 0.295739 CRCGN015_HEPG2_48H:P22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3958 H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RPS20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51368 MB-15-ZF03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.859789 BRCA1 ENCODE Transcription Factor Targets 1.0 null K562_Sirtinol_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0163277 BRD-K07939054 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13025 BCL3 ENCODE Transcription Factor Targets 1.0 null AHNAK Pathway Commons Protein-Protein Interactions 1.0 null 18625725-TableS1 GeneSigDB Published Gene Signatures 1.0 null tonsil_8a1 HPA Tissue Sample Gene Expression Profiles 1.0 1.09538 PMC11193738-41467_2024_48647_MOESM8_ESM.xlsx-Data_S5-Data_S5_HNF4A-bound_gene_targets_identified_from_ChIP-Seq_in_hepatic_cells_D8_Hep_and_HepG2_cells_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null MRPS9 Pathway Commons Protein-Protein Interactions 1.0 null GABPA ENCODE Transcription Factor Targets 1.0 null Perturb_13457_OE_Smn1_SRP366489 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.58497 GTEX-XUZC-1126-SM-4BOPZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.876675 GSE135030_3_v_7_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K11571815 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22535 RIDA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00542979 PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-1_names_TP53 Rummagene Transcription Factor Associations 2026 1.0 null intermediate part of r7B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12484 NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.839105 FAM120A Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K16879434 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47908 superficial stratum of r4BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30473 GTEX-QXCU-0006-SM-2TC5K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11913 CRCGN014_HEPG2_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.5226 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Secondary motor area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08081 H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null FOXP3-21729870-TREG-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MF-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EP300 ChEA Transcription Factor Targets 1.0 null H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Muscle - Skeletal GTEx Tissue Gene Expression Profiles 2023 1.0 3.21549 IRAK2_knockout_76_GSE24264 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.97091 GSE216274,GSE216292_4_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null Ribosome KEGG Pathways 2026 1.0 null GSE213588_10_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_16851_KO_Hnrnph1_SRP068520 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.63055 GTEX-WZTO-0011-R8A-SM-4E3II GTEx Tissue Sample Gene Expression Profiles 1.0 1.13564 ZNF263 ENCODE Transcription Factor Targets 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null anterior orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.29498 Perturb_15642_KD_Sf3a1_SRP043160 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.85532 16651409-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null CRCGN014_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.2432 H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE232714_0_v_1_raver1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-PWCY-1926-SM-3NB25 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.833716 CB-31-UO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -9.04736 OGA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24027 BA-68-FJ41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.212341 TAF7 ENCODE Transcription Factor Targets 1.0 null GSE153871_4_v_3_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null MPP-89 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.88982 AIMP2 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MEWO CCLE Cell Line Gene CNV Profiles 1.0 1.71057 PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_11_ZZZ3_ChIP-seq_in_shZZZ3-Genebody_ZZZ3 Rummagene Transcription Factor Associations 2026 1.0 null ME-31-RM40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.486254 GTEX-S7SF-1826-SM-3K2AD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0447 HNRNPA1 Pathway Commons Protein-Protein Interactions 1.0 null HNRNPL Pathway Commons Protein-Protein Interactions 1.0 null TARDBP Pathway Commons Protein-Protein Interactions 1.0 null PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE131649_4_v_5_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null DDX54 Pathway Commons Protein-Protein Interactions 1.0 null blood vessel TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE246461,GSE246463_5_v_2_mecp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CSTF3 Pathway Commons Protein-Protein Interactions 1.0 null JD-44-KF86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.251947 SW1783 GDSC Cell Line Gene Expression Profiles -1.0 -1.65617 SNU886 CCLE Cell Line Gene CNV Profiles -1.0 -2.5041 TAF1_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MZ in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28794 Mitochondrial translation elongation Reactome Pathways 2024 1.0 null DE-58-OW37_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.256204 Lung squamous cell carcinoma_LUSC_TCGA-37-4141-01A-02R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_AICAR_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.018213 HOXB6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.7274 POU6F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.0085 GABPA_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K13973870 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39355 PMC5651844-41467_2017_1173_MOESM10_ESM.xlsx-ZZZ3_occupied_genes-Supplementary_Data_7_ZZZ3_occupied_genes_and_overlaps_ZZZ3 Rummagene Transcription Factor Associations 2026 1.0 null Ebolavirus(EBOV)_6day_PBMCs_17725815_GSE8317 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.23738 GTEX-XAJ8-1326-SM-47JYT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.961235 SLC18A2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00527702 Acute Myeloid Leukemia_LAML_TCGA-AB-2986-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ERF::SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.9949 GSE195568_1_v_0_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.940933 interstitial nucleus of the posterior limb of the anterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42078 NKX2-4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.0989 CBX3_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS834T CCLE Cell Line Gene Expression Profiles -1.0 -1.75548 GSE227891_5_v_0_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null adrenal gland cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.32803 FF-86-NH56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.212625 H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K50315405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.65311 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10244410-41467_2023_39054_MOESM5_ESM.xlsx-PIE-LIN28B-GeneSymbol_LIN28B Rummagene Transcription Factor Associations 2026 1.0 null translation GO Biological Process Annotations 2023 1.0 null H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null lateral nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.990283 CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WC-09-GD62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.765044 BC-01-JL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.487366 HBQ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14029 U2AF1 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EIF4B Pathway Commons Protein-Protein Interactions 1.0 null LA-42-ER00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.222604 NF-21-HQ00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.278338 primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.15451 Secondary motor area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.26649 BRD-K69147598 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07624 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BB-62-MS83_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.240951 SKNAS CCLE Cell Line Gene CNV Profiles -1.0 -2.03013 A549_AICAR_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0190429 SCC-4 GDSC Cell Line Gene Expression Profiles 1.0 1.87244 rpmi8226 HPA Cell Line Gene Expression Profiles 1.0 1.07116 H3K4me1_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CD34+ BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.01226 H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T8EM-0226-SM-3DB7C GTEx Tissue Sample Gene Expression Profiles 1.0 0.874612 TJP1 Pathway Commons Protein-Protein Interactions 1.0 null umbilical cord blood TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-OHPK-0226-SM-3MJH6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11414 BRD-K18179332 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08717 SIX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRPL13 Pathway Commons Protein-Protein Interactions 1.0 null M-1 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.920973 BT-474 COSMIC Cell Line Gene CNV Profiles 1.0 2.49065 Lung squamous cell carcinoma_LUSC_TCGA-37-4133-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K89584810 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44012 macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K32535831 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05366 POU6F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.5512 ESF1 Pathway Commons Protein-Protein Interactions 1.0 null ATF3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.18609 GTEX-WWYW-0011-R11A-SM-3NB38 GTEx Tissue Sample Gene Expression Profiles 1.0 2.58428 MRPL46 Pathway Commons Protein-Protein Interactions 1.0 null RD-90-OY66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.4808 JAR DepMap CRISPR Gene Dependency 1.0 2.06987 LHX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4634 GSE210383_0_v_1_trim71_mouse RummaGEO Gene Perturbation Signatures -1.0 null Oligodendroglioma_CNS - Brain (MMHCC)_GSE2223 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.82842 BRD-K62202988 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01322 GTEX-SNOS-0006-SM-32PLH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4123 GTEX-N7MT-0011-R3a-SM-2I3GC GTEx Tissue Sample Gene Expression Profiles 1.0 2.43172 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05133 ZBED5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2264 EEF1D Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WL46-0011-R9A-SM-3MJFP GTEx Tissue Sample Gene Expression Profiles 1.0 2.23473 H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21337 GA-04-JM33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.378567 CRCGN015_MCF10A_48H:M22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.63406 Perturb_1983_KO_Nmp4_SRP137142 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 MGME1 Pathway Commons Protein-Protein Interactions 1.0 null CB-87-RB49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.231387 Lung squamous cell carcinoma_LUSC_TCGA-34-5234-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00575701 ZFP42-18358816-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.746654 POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE175787_11_v_10_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-PX3G-1626-SM-2S1PT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03271 OVTOKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.97037 E2F1-17053090-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.23822 rostral migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.888164 CDX2-20551321-CACO-2-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null DNAJA3 Pathway Commons Protein-Protein Interactions 1.0 null PMC8593586-mmc2.xlsx-LIN28A_interactome-Unnamed_1_LIN28A Rummagene Transcription Factor Associations 2026 1.0 null YY1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BTBD8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00522472 NCI-H2405 GDSC Cell Line Gene Expression Profiles -1.0 -1.43636 MCF7_TGX-221_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0138194 H3K36me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT1 ENCODE Transcription Factor Targets 1.0 null mantle zone of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15024 tardbp_19910924_hek293e_lof_human_gpl570_gds3730 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.434994 PKP3 Pathway Commons Protein-Protein Interactions 1.0 null GSE203362_0_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null PDK3 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN017_MCF10A.WT.HP_24H:P20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4065 abnormality of metabolism/homeostasis GWASdb SNP-Phenotype Associations 1.0 0.050995 PMC5651844-41467_2017_1173_MOESM7_ESM.xlsx-ZZZ3_ChIP-seq_peaks-Unnamed_6_ZZZ3 Rummagene Transcription Factor Associations 2026 1.0 null TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_6083_KD_UBE2I_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CHI3L2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00782611 macromolecular complex subunit organization GO Biological Process Annotations 2015 1.0 null Perturb_15607_KO_Dnmt1_SRP247926 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.32295 H3K9ac_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EIPA DeepCoverMOA Drug Mechanisms of Action -1.0 -0.57 DA-66-OE69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.200134 KCTD12 Pathway Commons Protein-Protein Interactions 1.0 null MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC3500769-srep00875-s3.xls-GATA3-Time_4_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A65D-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary somatosensory area, mouth, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01184 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR2F2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EIF3E Pathway Commons Protein-Protein Interactions 1.0 null IGR1 CCLE Cell Line Gene CNV Profiles -1.0 -1.42676 Ribonucleoprotein complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Posterior parietal association areas, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32044 DC-51-WE27_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.663173 Organelle envelope COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 MYC_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS 936.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.41475 CRCGN017_MCF10A.TP53.M_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.13112 SNRNP70 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-X8HC-0226-SM-4E3K1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25885 BRD-K67632894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69006 ME-31-RM40_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.440958 Prostate adenocarcinoma_PRAD_TCGA-EJ-A65M-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12809574-ao5c10968_si_001.pdf-19-MBD3_MBD3 Rummagene Transcription Factor Associations 2026 1.0 null POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1225-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GSE158834_11_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null Urinary system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mitochondrial translation Reactome Pathways 2024 1.0 null EXOSC4 Pathway Commons Protein-Protein Interactions 1.0 null Organelle biogenesis and maintenance Reactome Pathways 2014 1.0 null H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null AURKB_knockdown_92_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.65454 BRD-K24997610 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49798 laterodorsal subdivision of area 8 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0449 GTEX-TML8-0005-SM-32QPA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81885 ELF1 ENCODE Transcription Factor Targets 1.0 null POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary somatosensory area, mouth, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54991 GTEX-WHSE-0011-R8A-SM-3P5Z1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.1959 BRD-K12067186 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53541 Anterior cingulate area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26342 HS 695T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11341 55S ribosome, mitochondrial CORUM Protein Complexes 1.0 null kidney disease GWASdb SNP-Disease Associations 1.0 0.190317 CL11 DepMap CRISPR Gene Dependency 1.0 2.05859 H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null USF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null testis_7f HPA Tissue Sample Gene Expression Profiles -1.0 -1.3266 ITGA2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0063927 DKC1 Pathway Commons Protein-Protein Interactions 1.0 null ractopamine LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32104 Perturb_1982_KO_Nmp4_SRP137142 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 WC-59-RG09_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.55934 benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042161 BRD-K97746859 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62603 ZNF384_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR1 ENCODE Transcription Factor Targets 1.0 null CHD1 ENCODE Transcription Factor Targets 1.0 null GTEX-OXRO-0226-SM-3LK6F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.955444 BRD-K05248013 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76044 Retrosplenial area, dorsal part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09649 SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3164 SNRPE Pathway Commons Protein-Protein Interactions 1.0 null CCT2 Pathway Commons Protein-Protein Interactions 1.0 null A549_Roscovitine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160013 Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HF-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null r5 part of A5 noradrenergic cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20886 GDM-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.48519 PMC8043114-Table_7.xlsx-PE1-gene_name_s_ETV3 Rummagene Transcription Factor Associations 2026 1.0 null thyroid BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.62275 H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XV7Q-1626-SM-4BRWC GTEx Tissue Sample Gene Expression Profiles 1.0 0.835038 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QXCU-1926-SM-48FE4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.94332 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.21704 r10 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.89178 H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8094-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WT1-20215353-NEPHRON PROGENITOR-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-RWSA-0005-SM-2XCAO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.65341 Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SOD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06377 EGR1 ChEA Transcription Factor Targets 1.0 null GSE147943_0_v_3_cited2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZP-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HSPA1B Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-5429-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null A549_PCI-34051_10然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0108768 membrane GO Cellular Component Annotations 2015 1.0 null Microsporidian TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.583 Perturb_2897_KO_Il33_SRP076391 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.55945 GSE57871_1_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null KHDRBS1 Pathway Commons Protein-Protein Interactions 1.0 null H4K8ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null HNF4A Pathway Commons Protein-Protein Interactions 1.0 null BRD-K90103010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.83304 H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null esophagus_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.85533 TBX19 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.0719 H2AFZ ENCODE Transcription Factor Targets 1.0 null mantle zone of r10BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06289 Parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.12647 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TCF12 ENCODE Transcription Factor Targets 1.0 null POLR2H Pathway Commons Protein-Protein Interactions 1.0 null GSE216273,GSE216292_14_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null KA-29-AB08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.248443 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 RPLP2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K95672449 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.87741 RPL23A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.84447 BF-22-EP86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.329873 H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null CI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.15109 GABPA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K55489373 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39236 NCI-H23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.839105 intermediate part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0606 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ACAD9 Pathway Commons Protein-Protein Interactions 1.0 null H3ac_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Cystic Fibrosis_Intestinal Epithelium_GSE765 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.00448 viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052812 REC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.8427 H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null 2875_ANTKMT_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.578378 PLRG1 Pathway Commons Protein-Protein Interactions 1.0 null USF2 ENCODE Transcription Factor Targets 1.0 null GTEX-RWS6-2326-SM-2XCB4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18843 MYOD1_myocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.904984 GADD45GIP1 Pathway Commons Protein-Protein Interactions 1.0 null SA-32-CC58_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.423471 GSE216273,GSE216292_0_v_6_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null HNRNPD Pathway Commons Protein-Protein Interactions 1.0 null BRD-K96945247 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08353 KMS34 CCLE Cell Line Gene Expression Profiles 1.0 1.69831 GSE196699_7_v_3_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null Organellar large ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.113 BRD-U64521890_XMD16-144_HT29_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LMX1A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.2064 Dyskinetic cerebral palsy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.095 H3K4me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K96069147 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.53479 BAG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6692 DNAJC5B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00653293 NRF1 ENCODE Transcription Factor Targets 1.0 null CRCGN014_HEPG2_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.13685 PMPCB Pathway Commons Protein-Protein Interactions 1.0 null sublayer 6a of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34632 UQCRFS1 Pathway Commons Protein-Protein Interactions 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A8HY-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_10970_KO_Cd109_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.52482 GSE146045_1_v_0_lama3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_12696_KO_Ezh2_SRP222765 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.71521 chr11_73826194_T_A_b38 GTEx eQTL 2025 1.0 3.74656 CKAP4 Pathway Commons Protein-Protein Interactions 1.0 null NAA38 Pathway Commons Protein-Protein Interactions 1.0 null POLDIP2 Pathway Commons Protein-Protein Interactions 1.0 null GTF2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K74015591 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16633 r10 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53654 Perturb_2977_KD_H2A.Z_SRP043544 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.10186 nih 3T3 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.31836 MRPL16 Pathway Commons Protein-Protein Interactions 1.0 null EB1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.984503 GTEX-N7MS-0011-R8a-SM-2YUMK GTEx Tissue Sample Gene Expression Profiles 1.0 1.10168 GSE135030_11_v_7_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null AC-84-QG99_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.484047 HMGN3 ENCODE Transcription Factor Targets 1.0 null GTEX-Q2AH-1026-SM-48TZI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06878 MTIF2 Pathway Commons Protein-Protein Interactions 1.0 null BTS LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.93365 CA-48-SW47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.96643 Perturb_6561_KO_Stxbp5l_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.448 CRCGN011_HEPG2_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.344 H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null PC-62-AQ92_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.378143 HOXB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.7265 CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZFR Pathway Commons Protein-Protein Interactions 1.0 null GTEX-PWOO-2326-SM-2S1PQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.82891 H3K56ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 496100278_FWM_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.1575 MSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.3195 H3K4me1_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null DC-47-KV62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.219417 ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null dorsal thalamus_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.34396 PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-T6MN-0002-SM-3NMAH GTEx Tissue Sample Gene Expression Profiles 1.0 1.15225 RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.878544 4696_LSM6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.52459 fat_8b HPA Tissue Sample Gene Expression Profiles -1.0 -1.18429 GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01678 NCI-H2795 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00803 Clitoral gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.077 CBP-21632823-H3396-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Retrosplenial area, ventral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02345 H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE196671_6_v_1_obox4_mouse RummaGEO Gene Perturbation Signatures -1.0 null MRPL4 Pathway Commons Protein-Protein Interactions 1.0 null SMAD2/3-21741376-EPCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE188570,GSE188571_5_v_2_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null K562_ENMD-2076 L-Tartaric acid_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148409 CKMT1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00947747 GLDC Pathway Commons Protein-Protein Interactions 1.0 null mediodorsal nucleus of thalamus_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.39428 GTEX-S7PM-0426-SM-3NM91 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.918808 BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT474 CCLE Cell Line Gene Expression Profiles 1.0 1.7931 SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HL60 BioGPS Cell Line Gene Expression Profiles 1.0 1.34566 AB-09-EA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.584888 GTEX-Q2AH-1826-SM-2S1Q2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.875231 HOXC9 ChEA Transcription Factor Targets 1.0 null SUCLG1 Pathway Commons Protein-Protein Interactions 1.0 null 17009876-tableS1b GeneSigDB Published Gene Signatures 1.0 null BRD-K83481256 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08748 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EJ-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1954 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.954019 BRD-K47030799 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30621 YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4RV-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CP in caudal hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.67866 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE224131_3_v_1_mafb_human RummaGEO Gene Perturbation Signatures 1.0 null superficial stratum of r9Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52763 SP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.930136 H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE104022_1_v_0_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_1_ZZZ3_ChIP-seq_peaks-Genebody_ZZZ3 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K96243955 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26294 GSE211215_1_v_0_akr1b1_human RummaGEO Gene Perturbation Signatures -1.0 null WRNIP1 ENCODE Transcription Factor Targets 1.0 null GSE145323,GSE145324_1_v_0_rfx3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.1273 stratum radiatum of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.51495 intracellular organelle part GO Cellular Component Annotations 2015 1.0 null RPUSD4 Pathway Commons Protein-Protein Interactions 1.0 null ZNF217_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RERFLCAD2 CCLE Cell Line Gene CNV Profiles 1.0 1.64 AD-16-HL96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.80286 GTEX-WWYW-0011-R10A-SM-3NB35 GTEx Tissue Sample Gene Expression Profiles 1.0 1.29553 MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA ChEA Transcription Factor Targets 2022 1.0 null SUPT7L LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00526944 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 6 of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29714 FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.3834 MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.56657 hsa-miR-892b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GTEX-X5EB-2426-SM-4E3HX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.986434 oculomotor nucleus, main part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51879 H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TC-95-IR96_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.409474 HB-24-GP45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.588796 CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06134 SHOX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.3355 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.65944 BRD-K70940767 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03099 Perturb_10311_KO_Dkk3_SRP067265 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.95008 cerebellar cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.55781 Liver Neoplasms CTD Gene-Disease Associations 1.0 1.11639 Perturb_11019_KO_Prkcdbp_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.87817 Dimensional psychopathology (Cognitive) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.669897 GTEX-N7MT-0011-R2a-SM-2I3GI GTEx Tissue Sample Gene Expression Profiles 1.0 2.52692 BC-15-EL49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.267523 head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053676 EIF3A Pathway Commons Protein-Protein Interactions 1.0 null VF-79-GQ03_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.210378 Primary somatosensory area, trunk Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13196 EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03927 CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.32709 HD-62-KE69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.328528 ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.08782 Primary motor area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24878 Lung squamous cell carcinoma_LUSC_TCGA-37-5819-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-REY6-0626-SM-2TF4G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00775 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS751T CCLE Cell Line Gene Expression Profiles -1.0 -1.71875 APLN_KO_GDS3228_601_mouse_Heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null HARS2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K16727544 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37098 HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.24978 H3K79me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC12500496-262_2025_4178_MOESM2_ESM.xlsx-THP1_enriched_for_control-gene_name_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null K562_WP1066_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0194684 ZEB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hand1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.0311 H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-5068-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE217156_1_v_3_trpc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GABPA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.922992 Hepatic Cirrhosis_Hepatic Tissue_GSE1843 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.30325 OB glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38112 GTEX-QVUS-0011-R9A-SM-3GIJA GTEx Tissue Sample Gene Expression Profiles 1.0 1.46265 EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.96544 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:D02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.15365 TAF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE201309_1_v_0_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null SNU-668 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09512 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MRPS31 Pathway Commons Protein-Protein Interactions 1.0 null GSE182680,GSE182683_0_v_8_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null COV362 CCLE Cell Line Gene CNV Profiles 1.0 1.37971 H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN014_HEPG2_24H:J18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.708 H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles -1.0 -2.02293 CF-24-KQ98_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.993525 CRCGN015_MCF10A_48H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.83064 posterior cortical nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.954944 BRD-K24220535 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12111 DAZAP1 Pathway Commons Protein-Protein Interactions 1.0 null GSE226355,GSE226357_1_v_4_ybx1_human RummaGEO Gene Perturbation Signatures 1.0 null OCIM1 CCLE Cell Line Gene CNV Profiles 1.0 2.31899 GSE233183,GSE233187_2_v_9_larp1_human RummaGEO Gene Perturbation Signatures -1.0 null 9534_UBL5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.567738 BATF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null urinary bladder TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K47254434 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.88252 SLC25A18 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MRPS21 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K50046044 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2287 Perturb_7084_KO_Perk_SRP309948 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.34327 SHP77 CCLE Cell Line Gene Expression Profiles 1.0 1.4727 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null fulvestrant_homo sapiens_gpl570_gse22533 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null 16715129-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null BRD-K82376876 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21069 CAMA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.7572 ARID3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AD-72-RI24_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.211245 H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 USF1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4412 layer 5 of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35836 U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.00882 TEAD4_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_2841_OE_MUSK_SRP357777 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -9.3095 POU5F1 ChEA Transcription Factor Targets 1.0 null SW900 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.31364 TCF12_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VJYA-0001-SM-3NMDJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.905735 Perturb_3780_KD_POLR2D_SRP041162 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE220058,GSE220059_0_v_1_prrc2b_human RummaGEO Gene Perturbation Signatures 1.0 null GSE168602,GSE168604_2_v_6_selumetinib_human RummaGEO Drug Perturbation Signatures -1.0 null AD-16-HL96_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.73501 EPRS Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null mitochondrial inner membrane GO Cellular Component Annotations 2023 1.0 null AA-23-FM46_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.404712 YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X62O-0005-SM-46MV1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.988425 SUPV3L1 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2228 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.995996 r4 part of medial pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30277 6791_PRPF18_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.531823 wt1_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl1261_gse15325 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.967831 Organelle lumen COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2744-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 6708_PPWD1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.654973 BRD-K23241743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01791 Primary somatosensory area, upper limb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56781 POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CUX1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Field CA3, stratum pyramidale Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11246 MRPL53 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-V1D1-1926-SM-4JBGX GTEx Tissue Sample Gene Expression Profiles 1.0 1.00575 RPS7 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K26836050 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18573 BRD-K43981353 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33035 GTEX-RU72-0011-R6A-SM-2TF71 GTEx Tissue Sample Gene Expression Profiles 1.0 0.88632 AGK Pathway Commons Protein-Protein Interactions 1.0 null GSE182680,GSE182683_5_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K26790127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0626 H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BE-38-UW72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.358819 ventrolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.46755 Field CA3, stratum oriens Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00319 external part of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33132 PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG Rummagene Transcription Factor Associations 2026 1.0 null GANC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00511598 mitochondrion organization GO Biological Process Annotations 2015 1.0 null TEAD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.9521 BRD-K71726959_N9-isoproplyolomoucine_HA1E_24.0_h_122.55_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.327608 Perturb_17677_KO_Foxa2_SRP139796 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.36588 C1QBP Pathway Commons Protein-Protein Interactions 1.0 null OV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.937265 GSE178113,GSE178116_0_v_1_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCAR1 Pathway Commons Protein-Protein Interactions 1.0 null NCI-H3118 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.16369 BRD-K79547691 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02203 GTEX-TMMY-0005-SM-33HBN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35938 EP300_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null DDOST Pathway Commons Protein-Protein Interactions 1.0 null creb1_22108299_heart_left_ventricle_lof_mouse_gpl1261_gds3660 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.922443 MRPS27 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 8214_SNIP1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.530044 ventral claustrum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06464 BRD-K31939603 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.94008 GSE158834_1_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K81372179 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.85514 GTEX-RU72-0011-R11A-SM-2TF6J GTEx Tissue Sample Gene Expression Profiles 1.0 1.20046 RNF2 Pathway Commons Protein-Protein Interactions 1.0 null TIMM23B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12218 GTEX-N7MS-0007-SM-2D7W1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21331 POLD1 Pathway Commons Protein-Protein Interactions 1.0 null EGR1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of isBI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3783 HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.22613 496100457_TCx_dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.08955 CC-84-JQ48_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.240819 SDHA Pathway Commons Protein-Protein Interactions 1.0 null MIA PACA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15485 CECR5 Pathway Commons Protein-Protein Interactions 1.0 null striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.863044 RA-49-ZB08_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.424466 SUDHL5 DepMap CRISPR Gene Dependency 1.0 2.02862 GRSF1 Pathway Commons Protein-Protein Interactions 1.0 null Mitochondrial ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.47 CDX2 ChEA Transcription Factor Targets 1.0 null LNZ308 CCLE Cell Line Gene CNV Profiles -1.0 -1.42932 UBA52 Pathway Commons Protein-Protein Interactions 1.0 null FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BC-54-ON71_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.221893 Adipose - Subcutaneous GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.20151 GTEX-N7MS-0011-R4a-SM-2HMKW GTEx Tissue Sample Gene Expression Profiles 1.0 1.50932 hippocampus (hippocampal formation)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.44067 TMLHE Pathway Commons Protein-Protein Interactions 1.0 null BRD-K48389907 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08256 vagina TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.729797 BRD-K39668479 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09968 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A82B-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-O2-A52S-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFIC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN010_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.37785 VNN2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00550834 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LV-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE228413_2_v_3_mavs_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-T6MN-0011-R5A-SM-32QPD GTEx Tissue Sample Gene Expression Profiles 1.0 0.838469 GA-94-MC54_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.467578 GTEX-QV31-0726-SM-3GAEG GTEx Tissue Sample Gene Expression Profiles 1.0 0.954821 SK-MEL-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.19336 GSE193993_5_v_6_sstr2_human RummaGEO Gene Perturbation Signatures -1.0 null JC-06-ED36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.320206 1408_CDC5L_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.71523 GTEX-WL46-0011-R6A-SM-3LK6X GTEx Tissue Sample Gene Expression Profiles 1.0 0.877721 GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.46334 MYBL2 ENCODE Transcription Factor Targets 1.0 null MZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10217 BRD-K46119789 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17817 GSE216043_3_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null SUB1 Pathway Commons Protein-Protein Interactions 1.0 null GSE235066_4_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Tegmental reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09805 Perturb_5342_KO_Mbd1/Mbd2/Mbd4/Mecp2_SRP337936 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.97192 H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TRIM28_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-0011-R11A-SM-3DB7N GTEx Tissue Sample Gene Expression Profiles 1.0 1.06544 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3451-01A-02R-1188-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TRMT112 Pathway Commons Protein-Protein Interactions 1.0 null Dorsal part of the lateral geniculate complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41771 TRIM28_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of r9Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01247 GTEX-UTHO-0011-R1A-SM-3GIJO GTEx Tissue Sample Gene Expression Profiles 1.0 3.15284 AUH Pathway Commons Protein-Protein Interactions 1.0 null cerebellar cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.19544 K029AX_SKIN CCLE Cell Line Proteomics 1.0 2.37845 GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.914292 CALU-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.83036 POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEKTE CCLE Cell Line Gene Expression Profiles -1.0 -1.49044 HDAC1 ENCODE Transcription Factor Targets 1.0 null EP300 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00486333 lateral ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.874823 MCAT Pathway Commons Protein-Protein Interactions 1.0 null AC-35-CK01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.371375 posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.24954 GSE205316,GSE205317_0_v_1_nrip1_mouse RummaGEO Gene Perturbation Signatures 1.0 null WHSC1 ENCODE Transcription Factor Targets 1.0 null GTEX-RNOR-2226-SM-2TF5O GTEx Tissue Sample Gene Expression Profiles 1.0 0.90264 mitochondrial matrix GO Cellular Component Annotations 2023 1.0 null NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.41151 H3K4me1_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ATP5MC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41895 GTEX-N7MT-0011-R8a-SM-2I5GU GTEx Tissue Sample Gene Expression Profiles 1.0 1.46214 ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K24167233 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68384 H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EA-18-FP00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.220849 GSE62843,GSE64371_2_v_3_furan_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-S7SE-0011-R11A-SM-2XCDD GTEx Tissue Sample Gene Expression Profiles 1.0 1.90879 TK Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.456 PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-Normal_309_TCF7_rep1_sorted_pea-Gene_Name_TCF7 Rummagene Transcription Factor Associations 2026 1.0 null RAD21_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4XX-0011-R5A-SM-46MWN GTEx Tissue Sample Gene Expression Profiles 1.0 2.04962 Primary somatosensory area, mouth, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12546 muscle GTEx Tissue Gene Expression Profiles -1.0 -0.897792 SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.944736 Entorhinal area, lateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.79212 primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.67963 FF-86-NH56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.255788 BRD-K29842194 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16835 ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r10 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02636 6625_PPIE_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.531221 MRPS2 Pathway Commons Protein-Protein Interactions 1.0 null amygdaloid complex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.22015 Kidney Chromophobe_KICH_TCGA-KL-8342-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRPF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03404 501A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.11392 GABPA_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2810-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRPF6 Pathway Commons Protein-Protein Interactions 1.0 null TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null striatum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04201 A549_Tranylcypromine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0173887 Ebolavirus(ZEBOV)_5day_Liver_None_GSE57214 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.12413 mitochondrial translational initiation GO Biological Process Annotations 2015 1.0 null bewo HPA Cell Line Gene Expression Profiles -1.0 -0.831002 H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HEPACAM2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00698814 H3K79me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K35119180 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07488 PC-68-HN64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.219989 SNAI2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7437 external globus pallidum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15637 KARPAS-45 GDSC Cell Line Gene Expression Profiles 1.0 1.48269 MECP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00444325 PL-21 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.898611 primary motor-sensory cortex (samples)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.928944 USF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75236 CRCGN016_MCF10A.WT.HP_24H:L24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.00814 CRCGN017_MCF10A.TP53.M_24H:A24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.33077 RPL23 Pathway Commons Protein-Protein Interactions 1.0 null MEF2A JASPAR Predicted Transcription Factor Targets 1.0 null PAX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.3023 r10 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14874 POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VDAC3 Pathway Commons Protein-Protein Interactions 1.0 null E2F6_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE207914_2_v_7_nudt7_mouse RummaGEO Gene Perturbation Signatures 1.0 null SDS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00542058 SLC25A5 Pathway Commons Protein-Protein Interactions 1.0 null H2AC13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01629 Orbital area, lateral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11085 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AY-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K21332842 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04864 PF-39-DY68_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.2867 CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PB-09-OE00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203827 CA-68-KG29_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.878597 DMS79 CCLE Cell Line Gene Expression Profiles 1.0 1.3871 r9 portion of ambiguous motor nucleus (postmigratory) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5254 C6/36 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.66 GSE163240_3_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PWN1-1626-SM-2S1OL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.873954 Brain Lower Grade Glioma_LGG_TCGA-HT-A4DV-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K17840858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36426 Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66T-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null umbilical cord TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4 Rummagene Transcription Factor Associations 2026 1.0 null AC-36-TL21_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.18155 Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.962555 K562_PJ34_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.024462 POU2F2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS11 Pathway Commons Protein-Protein Interactions 1.0 null layer 5 of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07453 BRD-K02061146 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52093 BRD-K51323894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23814 MRPL20 Pathway Commons Protein-Protein Interactions 1.0 null IGF2BP1 Pathway Commons Protein-Protein Interactions 1.0 null ID-07-YY69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.226692 STAT5A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_3H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1498 MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00463437 sulpiride-1887 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_fibroblast of lung_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_13792_KD_Nup153_SRP108774 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.01966 PPP1R8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05188 H3K36me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Intrinsic component of postsynaptic membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.516 ML1 CCLE Cell Line Gene Expression Profiles -1.0 -2.27082 Duchenne muscular dystrophy (DMD)_Muscle - Striated (Skeletal) - Diaphragm (MMHCC)_GSE1026 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.31273 STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER ChEA Transcription Factor Targets 2022 1.0 null POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193588_3_v_2_pax3_mouse RummaGEO Gene Perturbation Signatures -1.0 null IE-38-FB31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.398099 GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54192 CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MN-2526-SM-32PMN GTEx Tissue Sample Gene Expression Profiles 1.0 1.15132 TAF1_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HESX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.7686 NFATC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.3 DHX15 Pathway Commons Protein-Protein Interactions 1.0 null GSE140965_1_v_4_mybpc3_human RummaGEO Gene Perturbation Signatures -1.0 null blood TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FXR MotifMap Predicted Transcription Factor Targets 1.0 null BRD-K07600484 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58036 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VH-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_1127_KO_Myc_SRP168941 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.75221 CRCGN010_HEPG2_24H:J06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.058 H3K79me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lingula (I) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16254 Perturb_5042_Mut_Adnp_SRP313259 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.31724 K562_TMP195_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0197264 BRD-K73830970 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59655 posteromedial visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21067 BRD-K18688395 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51358 CRCGN012_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.2564 SARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55316 FB-66-UU47_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.49656 Primary somatosensory area, trunk, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49462 SUCLA2 Pathway Commons Protein-Protein Interactions 1.0 null Paraflocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3783 Primary visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04117 NAGK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00554229 Mitochondrial large ribosomal subunit CM4AI U2OS Cell Map Protein Localization Assemblies 1.0 null AB-17-WP43_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.334252 Entorhinal area, lateral part, layer 2b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.69783 EGR1-23403033-LIVER-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CREB1-23762244-HIPPOCAMPUS-RAT ChEA Transcription Factor Targets 2022 1.0 null PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_10_ZZZ3_ChIP-seq_in_shNT-Genebody_ZZZ3 Rummagene Transcription Factor Associations 2026 1.0 null EP300_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WYBS-1926-SM-3NM8N GTEx Tissue Sample Gene Expression Profiles 1.0 0.85098 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE147613_1_v_0_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:P22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.30443 GSE134214_0_v_1_ell2_human RummaGEO Gene Perturbation Signatures -1.0 null HSF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3189 BRD-K60578515 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61422 AA-22-UI44_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.223532 SARS-CoV MA15_Day2-PFU-10^2_None_GSE33266 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.95878 4578_LIG1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.511659 17699763-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null BRD-K46494135 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05885 Primary somatosensory area, lower limb, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.8584 cortico-medial group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.65569 SIX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.7581 KAT2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_A-366_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0185783 H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null fallopiantube_8e HPA Tissue Sample Gene Expression Profiles 1.0 1.30559 K562_Baricitinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.02466 MRPL11 Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_3073_KO_Ccl9_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.89948 GSE155162,GSE155169_1_v_2_buparlisib_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09162 BRD-K69073616 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30614 431_AQR_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.533418 ChIP_JARID1A_20064375 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BE-31-XV38_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.943256 GTEX-T6MO-0226-SM-32QOL GTEx Tissue Sample Gene Expression Profiles 1.0 0.832751 HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.42985 Leber congenital amaurosis_Retina_GSE3249 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.30197 organelle inner membrane GO Cellular Component Annotations 2023 1.0 null GTEX-QVJO-1325-SM-2S1QX GTEx Tissue Sample Gene Expression Profiles 1.0 1.35475 POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A6S8-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K06439119 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50451 POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU2F2_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_14680_KO_P2Y14_SRP044222 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.97447 NR3C1 ChEA Transcription Factor Targets 1.0 null JUND_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.74313 GSE225218_2_v_3_abcb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CCLP1 DepMap CRISPR Gene Dependency 1.0 2.14535 CTCF_fibroblast of villous mesenchyme_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pancreas_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.14492 USF1 ENCODE Transcription Factor Targets 1.0 null GTEX-QCQG-1326-SM-48U24 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24008 GTEX-R55C-0626-SM-2TF4Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.829415 MTNR1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00457393 Catalytic step 2 spliceosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.731 BRD-K82394273 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1783 BRD-K08533345 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08726 mammillary body, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.54953 intermediate stratum of r9Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19401 BRD-K32949071 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12722 mitochondrial membrane GO Cellular Component Annotations 2015 1.0 null GTEX-UTHO-3026-SM-3GAFB GTEx Tissue Sample Gene Expression Profiles 1.0 1.2434 POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F1-17053090-MCF7-human ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_5216_KO_Bap1_SRP162521 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.7323 C4II DepMap CRISPR Gene Dependency 1.0 2.01538 GSE163862_0_v_3_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE166783_3_v_2_tp53_human RummaGEO Gene Perturbation Signatures 1.0 null GSE200673,GSE200691_1_v_0_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.37148 GSE102757_1_v_0_panobinostat_mouse RummaGEO Drug Perturbation Signatures -1.0 null BRD-K04771555 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25684 CRCGN017_MCF10A.WT.HP_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.2227 PDLIM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12903 GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05224 SIX5_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH211 CCLE Cell Line Gene Expression Profiles 1.0 1.57925 HOXB5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.9019 FOXM1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE202434,GSE202438_4_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null K562_Tie2 kinase inhibitor_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0153588 H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K64299311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11896 AE-39-DG66_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.286274 BD-04-NG34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.203353 PRKCDBP Pathway Commons Protein-Protein Interactions 1.0 null SSTR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34654 Perturb_2212_KO_Gpnmb_SRP298977 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.49968 HNRNPA2B1 Pathway Commons Protein-Protein Interactions 1.0 null GSE70499_3_v_1_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null EP300_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-VUSG-0426-SM-3GIKD GTEx Tissue Sample Gene Expression Profiles 1.0 0.890578 STING1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00562663 BRD-K22298558 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70338 POU3F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.1029 Parkinson's Disease_Substantia Nigra_GSE7621 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.43279 GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57337 outer CP in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09035 H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SMIM20 Pathway Commons Protein-Protein Interactions 1.0 null UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO-818 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01854 K562_JQ1_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0161793 TAF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.236 t60-adrenal_consensus MoTrPAC Rat Endurance Exercise Training 1.0 2.50454 USF1_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null EIF3B Pathway Commons Protein-Protein Interactions 1.0 null GSE63048_11_v_6_morc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U7-06A-21R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE201309_5_v_0_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null ChIP_ZFP42_18358816 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null MCM5 Pathway Commons Protein-Protein Interactions 1.0 null TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE235587_2_v_0_mitoxantrone_human RummaGEO Drug Perturbation Signatures -1.0 null APRT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00400511 BRD-K03713632 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45743 HDLBP Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null amygdalo-striatal transition Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01247 orbital frontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04964 ATF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27223 IZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.952178 HSD17B4 Pathway Commons Protein-Protein Interactions 1.0 null DGKK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00438 MSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.7358 HDAC6 ENCODE Transcription Factor Targets 1.0 null IC-28-HS37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.41169 CIAO2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09001 MITF ChEA Transcription Factor Targets 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7588-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NF-21-HQ00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.328938 REST_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsalstriatum BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.847268 CA1 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.21489 HE-22-JR80_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.219936 JUN_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K23956364 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31855 MYOG_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.25253 H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r3 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.01773 FLAD1 Pathway Commons Protein-Protein Interactions 1.0 null 496100555_TCx_no dementia_no TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.02047 Perturb_13448_OE|KD_PAX2|PTEN_SRP279768 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 10.2088 GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41537 TFEB ChEA Transcription Factor Targets 1.0 null GTEX-O5YV-2026-SM-2D7VS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.968783 H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SIX5_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K54606188_(+)-JQ1_HT29_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-R55E-0011-R11A-SM-2TC6I GTEx Tissue Sample Gene Expression Profiles 1.0 0.908106 orbital frontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.998238 K562_S3I-201_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0177066 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AF-16-IB77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.584832 YAE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 6.20024 Primary somatosensory area, lower limb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45776 fat_a.V1 HPA Tissue Sample Gene Expression Profiles -1.0 -0.911735 cytoplasmic part GO Cellular Component Annotations 2015 1.0 null PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null DDRGK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00554597 3635_HAUS2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.601671 PBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.0212 Nrf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 45.0626 RNMTL1 Pathway Commons Protein-Protein Interactions 1.0 null MAX_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HT-29 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.8481 Zic1::Zic2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.6514 GTEX-X88G-0004-SM-47JZ6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.23979 MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null gemcitabine_homo sapiens_gpl96_gse6914 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RPL6 Pathway Commons Protein-Protein Interactions 1.0 null ISX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.4746 ZC3HAV1 Pathway Commons Protein-Protein Interactions 1.0 null IL1RAP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00693928 NCI-H460 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.862691 GTEX-UTHO-0011-R6A-SM-3GIJW GTEx Tissue Sample Gene Expression Profiles 1.0 1.48167 T47D DepMap CRISPR Gene Dependency 1.0 2.04076 GSE206270_1_v_0_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null KYSE-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00483 PB-09-OE00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.214182 BRD-K30269093 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06617 mediodorsal nucleus of thalamus_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.11003 Perturb_16922_OE_miR26a_SRP216065 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.98942 GTEX-WFJO-0005-SM-3GIKY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26413 CHCHD2 Pathway Commons Protein-Protein Interactions 1.0 null CHD1-26751641-CHIP-SEQ-LNCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K66401298 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.93228 CDC16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20957 POU5F1-18692474-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CBX3_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1703 DepMap CRISPR Gene Dependency 1.0 2.00406 RPS6 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRPL38 Pathway Commons Protein-Protein Interactions 1.0 null PTBP1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K38240683 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05676 DHCR7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00456555 ZFP90 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00575887 FXR1 Pathway Commons Protein-Protein Interactions 1.0 null organelle lumen COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 ALDH2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QMR6-0011-R11A-SM-32PKK GTEx Tissue Sample Gene Expression Profiles 1.0 1.06868 Perturb_10365_KD_Setd2_SRP184682 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.13052 BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.429258 superficial stratum of r3BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.85607 GTEX-R55E-0011-R8A-SM-2TC66 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28352 496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.97999 GSE240386,GSE242143_1_v_6_morc2_human RummaGEO Gene Perturbation Signatures -1.0 null MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE139966_4_v_3_figla_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF24 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3219 CRCGN016_MCF10A.TP53.M_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.277 ZNF345 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69291 GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24643 ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.560943 ATF2 ENCODE Transcription Factor Targets 1.0 null MCF7 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.20944 Perturb_706_KD_SETDB1_SRP116955 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE246911,GSE246913_4_v_1_arid1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null GE-47-OO30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.439827 BCLAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null WC-16-IR43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.270192 Perturb_3119_KO_Scarf2_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.24055 Primary somatosensory area, trunk, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33031 GTEX-RVPV-1226-SM-2TF73 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08064 GSE224004,GSE224005_0_v_8_chd4_human RummaGEO Gene Perturbation Signatures -1.0 null organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.0524 upper (rostral) rhombic lip_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.9919 ChIP_ASH2L_23239880 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null EP300_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EIF3H Pathway Commons Protein-Protein Interactions 1.0 null TLCD3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57432 GTEX-TSE9-0526-SM-3DB7Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02008 Aiolos_NULL MUTATION_GDS3473_572_mouse_Bone marrow pre-BII cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K86228587 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.56713 BRD-K82126187 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73215 primary auditory cortex (core)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.178 FLO-1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.98431 nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05469 AC-44-UR36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.211705 GTEX-XBEC-0326-SM-4AT4M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.982235 API5 Pathway Commons Protein-Protein Interactions 1.0 null GABPA_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_11012_KO_Phtf1_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.66811 basolateral nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17938 MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE118766_1_v_0_ifng_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-U4B1-0006-SM-3DB8E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.961288 PSMA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29567 GSE158320,GSE183351_0_v_1_lin28b_human RummaGEO Gene Perturbation Signatures -1.0 null 5729_NOC2L_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.658109 CD-80-ZD47_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.280996 HNRNPA0 Pathway Commons Protein-Protein Interactions 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R3RS-0726-SM-3GIJR GTEx Tissue Sample Gene Expression Profiles 1.0 1.57593 GSE125219,GSE125221_4_v_8_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-MEL-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.02806 BRD-K81031146 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02141 TAF1 ENCODE Transcription Factor Targets 1.0 null KARPAS-299 GDSC Cell Line Gene Expression Profiles -1.0 -1.53406 GTEX-X4XX-0011-R10B-SM-46MWO GTEx Tissue Sample Gene Expression Profiles 1.0 0.874089 NEK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00393629 BRD-K18801549 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07794 GTEX-RVPV-0011-R11A-SM-2TF6F GTEx Tissue Sample Gene Expression Profiles 1.0 0.850262 cerebellar cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.56175 H3K27ac_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cerebellar vermis Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.976828 GTEX-TML8-0001-SM-3NMAF GTEx Tissue Sample Gene Expression Profiles 1.0 1.30128 FOXP3 ChEA Transcription Factor Targets 1.0 null gata3_22922362_treg_cd4poscd25posyfppos_lof_mouse_gpl8321_gse39864 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.050514 H3K27ac_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mantle zone of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02408 HOXA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.5079 IA-76-ZU47_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.669818 CMC1 Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_5482_KD_Ctnnb1_SRP130920 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.3167 GTEX-T5JW-1126-SM-4DM5V GTEx Tissue Sample Gene Expression Profiles 1.0 1.17462 BRD-K30589514 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55669 Pancreatic adenocarcinoma_PAAD_TCGA-FB-A5VM-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMC3 ENCODE Transcription Factor Targets 1.0 null BRD-K42828928 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46565 H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null HCFC1_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-JV-A5VF-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X585-0011-R4B-SM-46MVH GTEx Tissue Sample Gene Expression Profiles 1.0 1.94802 PC-87-OG75_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.333596 MDA-MB-415 GDSC Cell Line Gene Expression Profiles -1.0 -1.41894 PRPF4 Pathway Commons Protein-Protein Interactions 1.0 null HDAC2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00483 H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null WM88_SKIN CCLE Cell Line Proteomics 1.0 3.5999 hsa-miR-4680-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GFI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.6327 POLR2A Pathway Commons Protein-Protein Interactions 1.0 null TBCD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15795 GSE150669_2_v_1_roxadustat_mouse RummaGEO Drug Perturbation Signatures -1.0 null SJSA1_BONE CCLE Cell Line Proteomics 1.0 2.26045 BRD-K25982056 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64807 CRCGN017_MCF10A.TP53.M_24H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.01466 mantle zone of APal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26383 H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null mediodorsal nucleus of thalamus_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.57291 abnormality of the genitourinary system GWASdb SNP-Phenotype Associations 1.0 0.061367 r9 part of the vestibular column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00938 GSE190384,GSE190386_2_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XMD1-0011-R9A-SM-4AT49 GTEx Tissue Sample Gene Expression Profiles 1.0 2.35972 SRF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100412_FWM_possible Alzheimer's disease_TBI_87_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.40918 CASP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15559 PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE213588_8_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE77108_8_v_7_saha_human RummaGEO Drug Perturbation Signatures -1.0 null intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 HOXC13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.3374 A549_BMS-265246_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158461 DDX6 Pathway Commons Protein-Protein Interactions 1.0 null MZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.32422 CRCGN015_MCF10A.WT.HP_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.49226 PVRIG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2541 DLX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.8585 SIN3A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_DBP_ALL-SYMBOL_DBP Rummagene Transcription Factor Associations 2026 1.0 null BRD-K28488100 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.40832 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3473-01A-01R-1193-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SARS-dORF6_96Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.90062 PYCRL Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null paracentral lobule, posterior part, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.933521 ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.14912 SOX15 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K80897487 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54326 AP2M1 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_16898_KD_Taf15_SRP069788 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.79468 Perturb_11749_KO_Cxcr2_SRP252097 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.39537 PTCD3 Pathway Commons Protein-Protein Interactions 1.0 null YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.12529 Rectum adenocarcinoma_READ_TCGA-DC-4745-01A-01R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE211744_2_v_4_gdf15_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VDR-23849224-CD4+-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -2.54504 DUXA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.2171 Perturb_6559_KO_Rabl2_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 BRD-K01668149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85666 JF-84-QZ64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.26912 FLI1 ENCODE Transcription Factor Targets 1.0 null SSB Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K36282114 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47338 H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ATF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Perturb_4714_KO_Hnrnpu/Trp53_SRP331236 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 amygdaloid complex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.26187 BRD-K02362691 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.761 Perturb_707_KD_SETDB1_SRP116955 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null G3BP1 Pathway Commons Protein-Protein Interactions 1.0 null NDUFV1 Pathway Commons Protein-Protein Interactions 1.0 null FE-10-KQ78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.807618 abnormality of nitrogen compound homeostasis GWASdb SNP-Phenotype Associations 1.0 0.338564 BRD-K91766181 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14047 CEBPB_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null U937 DepMap CRISPR Gene Dependency 1.0 2.1058 GSE77108_6_v_7_saha_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K26552461 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68408 RPS29 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59266 MRPS24 Pathway Commons Protein-Protein Interactions 1.0 null K562_Mercaptopurine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0215436 GSE211286_4_v_6_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-7889-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2052 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.837585 K562_AMG-900_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160465 MTPAP Pathway Commons Protein-Protein Interactions 1.0 null DB-54-GQ68_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.235733 macromolecular complex disassembly GO Biological Process Annotations 2015 1.0 null APOL2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00453313 BRD-K89805365 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00308 BC-10-SB73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.32941 Prelimbic cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.683 GTEX-XPVG-2726-SM-4B66W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02824 POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLC25A3 Pathway Commons Protein-Protein Interactions 1.0 null Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.092 Primary somatosensory area, unassigned, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.13722 CPSF6 Pathway Commons Protein-Protein Interactions 1.0 null RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_5476_OE_Sox9_SRP375106 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.0113 CHD1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BE-79-QU25_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.248443 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null K562_AG-14361_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0199519 cellular biosynthetic process GO Biological Process Annotations 2015 1.0 null BT12 DepMap CRISPR Gene Dependency 1.0 2.19615 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 EMG1 Pathway Commons Protein-Protein Interactions 1.0 null non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null organelle GO Cellular Component Annotations 2015 1.0 null CCDC50 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00497178 POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QC-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AF4-26711339-SEM-HUMAN-BLOOD-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null BRD-K16551475 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16157 RFX5 ENCODE Transcription Factor Targets 1.0 null TIAL1 Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CD-01A-21R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null disease GWASdb SNP-Disease Associations 1.0 0.024622 VENTX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.5265 SMIM10L2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18798 BRD-K51577368 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23862 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.851105 TBC1D15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2357 BRD-K45799338 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11521 17660535-TableS4a GeneSigDB Published Gene Signatures 1.0 null PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SALE CCLE Cell Line Gene Expression Profiles -1.0 -1.99252 RPL7A Pathway Commons Protein-Protein Interactions 1.0 null mantle zone of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3218 JF-39-BZ76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.229864 H3K4me1_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null RPL10 Pathway Commons Protein-Protein Interactions 1.0 null globus pallidus, external segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0407 Primary somatosensory area, upper limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.69973 BRD-K89328601 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76694 DD-74-PJ26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.264605 MGP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00905754 Secondary motor area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25065 SCML2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.233 POLR2AphosphoS5_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ERBB2_druginhibition_8_GDS2139 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.39889 BRD-K66735566 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89202 16872506-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null GSE111881_0_v_1_znf768_human RummaGEO Gene Perturbation Signatures 1.0 null bed nucleus of stria terminalis, lateral amygdaloid division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57249 KMS20 CCLE Cell Line Gene CNV Profiles -1.0 -1.54567 TEAD4-22529382-TROPHECTODERM-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null IRF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JJ012 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.91391 YY1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KCL22 DepMap CRISPR Gene Dependency 1.0 2.13124 CTCF_fibroblast of upper leg skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70919 CRCGN016_MCF10A.WT.HP_24H:D03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.15936 YY1-33199912-293T-HUMAN-KIDNEYEMBRYO ChEA Transcription Factor Targets 2022 1.0 null MOLT-16 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.07395 GTF3C1 Pathway Commons Protein-Protein Interactions 1.0 null PANC-03-27 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.68483 BRD-A46317335 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02686 DC-70-EK34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.958497 E2F4 ENCODE Transcription Factor Targets 1.0 null SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null u266 HPA Cell Line Gene Expression Profiles -1.0 -1.01293 Primary somatosensory area, mouth Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62041 EP300_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.14616 CRCGN013_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.093 POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MYC-22102868-BL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null AKR1C1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00499449 BRD-K34311186 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.3553 REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.24512 BRD-K27139040 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19212 PUSL1 Pathway Commons Protein-Protein Interactions 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BN-01B-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE216043_7_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null TEAD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.21915 SARS-ddORF6_60Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.10323 GABPA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZCCHC3 Pathway Commons Protein-Protein Interactions 1.0 null EB-67-WB79_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.553155 HOXA5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.0271 U343 CCLE Cell Line Gene Expression Profiles -1.0 -1.62656 GTEX-TSE9-0011-R8A-SM-3DB7R GTEx Tissue Sample Gene Expression Profiles 1.0 1.02504 H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_6092_KD_YY2_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 MCF7_Barasertib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0127564 chr11_73780085_G_A_b38 GTEx eQTL 2025 1.0 1.29908 GABPA_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RL GDSC Cell Line Gene Expression Profiles 1.0 1.5816 IFT80 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17611 superficial stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.94752 BRD-K15940717 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48693 6555_POLR3A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.01368 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.78545 GTEX-RVPU-2226-SM-2XCAQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.867818 Perturb_1892_KO_Klf2_SRP257906 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.92252 H2AC12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24441 BRD-K92456318 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70353 HTC-C3 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.95716 496100346_FWM_no dementia_TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.47854 GTEX-RNOR-0011-R7A-SM-2TF4V GTEx Tissue Sample Gene Expression Profiles 1.0 0.832393 TEAD4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.1383 H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.044914 BRD-K31546068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45742 GTEX-NL3H-0011-R11A-SM-2I3E6 GTEx Tissue Sample Gene Expression Profiles 1.0 2.1075 GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18264 PARG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00756862 GSE158834_7_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.21054 RPS28 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K06320746 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64831 16643655-1300GenesList GeneSigDB Published Gene Signatures 1.0 null r8 portion of ambiguous motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25949 GSE205729,GSE205731_2_v_3_tazemetostat_human RummaGEO Drug Perturbation Signatures -1.0 null YY2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.3294 mitochondrial inner membrane GO Cellular Component Annotations 2015 1.0 null BHLHE40 ENCODE Transcription Factor Targets 1.0 null H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Tofacitinib_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0178188 hsa-miR-4789-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 BRD-K39449566 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10385 ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null substantia nigra reticulata, m1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09213 Mitochondrial envelope COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 GSE126621,GSE126920_1_v_0_dppa4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE216043_10_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Central amygdalar nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02098 GTEX-WL46-2826-SM-3LK81 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18987 ETS1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XV7Q-2126-SM-4BRVX GTEx Tissue Sample Gene Expression Profiles 1.0 1.29121 JUN ENCODE Transcription Factor Targets 1.0 null GTEX-SN8G-0226-SM-4DM6B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17393 GSE216043_11_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null TECR Pathway Commons Protein-Protein Interactions 1.0 null Primary somatosensory area, mouth, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24316 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.030808 mitochondrial ribosome COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 BRD-K16432886 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73484 LARS Pathway Commons Protein-Protein Interactions 1.0 null TIM23 mitochondrial import inner membrane translocase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.009 GSE217552_3_v_0_fisetin_human RummaGEO Drug Perturbation Signatures -1.0 null Arrhythmogenic Right Ventricular Cardiomyopathy_Myocardial tissue_GSE4120 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.08968 GSE213588_9_v_5_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XMK1-0001-SM-4B64F GTEx Tissue Sample Gene Expression Profiles 1.0 1.76712 Perturb_13296_OE_Pik3ca_SRP173204 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.02654 SNU-C4 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.705 EP300-20729851-FORBRAIN-MIDBRAIN-LIMB-HEART-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-U8XE-0626-SM-3DB8U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12138 ER-23166858-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE111247_11_v_13_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null K562_Roscovitine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0164433 chr11_73859652_C_T_b38 GTEx eQTL 2025 1.0 1.43273 CTCF ENCODE Transcription Factor Targets 1.0 null GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44872 GSTM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49293 GSE95685_6_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null RPL36A Pathway Commons Protein-Protein Interactions 1.0 null Perturb_15678_KD_Srsf6_SRP313287 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 12.3293 PTRF Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.10853 BRD-K67661742 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.34136 GSE248858_1_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null ED-81-ZH14_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.374308 Insulinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.692 KDM5A ChEA Transcription Factor Targets 1.0 null mitochondrial membrane GO Cellular Component Annotations 2025 1.0 null A204 GDSC Cell Line Gene Expression Profiles -1.0 -1.84383 GSE193258,GSE193259_9_v_13_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_15670_KD_Sf3a1_SRP043160 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.79408 IB-56-JN40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.218675 TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-96-HO33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.24227 ZR75_1 BioGPS Cell Line Gene Expression Profiles 1.0 1.03907 GTEX-T6MN-0011-R8A-SM-32QP3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32579 r10 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.41687 GSE75976_3_v_4_abl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-U8T8-0426-SM-3DB8X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00385 BRD-K94888615 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69638 KHSRP Pathway Commons Protein-Protein Interactions 1.0 null BRD-K81949875 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.60991 inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.95183 H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K56126872 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.1459 SCC25 CCLE Cell Line Gene CNV Profiles 1.0 2.00758 NF-21-HQ00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.482127 BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.45822 Perturb_16484_KO_Ikk2_SRP131881 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.75675 GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.6029 BRD-K24838542 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65149 GSE125403_7_v_6_venetoclax_human RummaGEO Drug Perturbation Signatures 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LG-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AP-1 MotifMap Predicted Transcription Factor Targets 1.0 null RPS18 Pathway Commons Protein-Protein Interactions 1.0 null fh1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.927 RFX5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Roscovitine_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.022232 DB-73-BC12_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.320112 GSE135705_5_v_3_corticosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null SKMEL28 CCLE Cell Line Gene CNV Profiles -1.0 -1.64111 mitochondrial translation GO Biological Process Annotations 2025 1.0 null H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE182854_2_v_0_sirt1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE218060_7_v_0_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02856 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular_component LOCATE Curated Protein Localization Annotations 1.0 null FC-13-VS25_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.9737 STAT1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null kidney failure GWASdb SNP-Disease Associations 1.0 0.382855 Perturb_1824_KO_Ifnar_SRP371304 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.9609 KPNA2 Pathway Commons Protein-Protein Interactions 1.0 null DMS-53 GDSC Cell Line Gene Expression Profiles 1.0 2.84987 BRD-K54028343 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29544 macromolecule biosynthetic process GO Biological Process Annotations 2015 1.0 null Perturb_10408_KO_Eda_SRP197326 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.41601 Prostate adenocarcinoma_PRAD_TCGA-YL-A8S9-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IC-98-UO17_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.240896 H3K4me1_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TCF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37024 GSE130676_0_v_1_suds3_human RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.01562 GTEX-S7SE-0011-R2A-SM-2XCDC GTEx Tissue Sample Gene Expression Profiles 1.0 1.35455 NCOR1-26117541-K562-HUMAN ChEA Transcription Factor Targets 2022 1.0 null POLR2I Pathway Commons Protein-Protein Interactions 1.0 null MRPL24 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K92644013 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05122 striatum_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19421 GSE240386,GSE242143_1_v_4_morc2_human RummaGEO Gene Perturbation Signatures -1.0 null POLR1C Pathway Commons Protein-Protein Interactions 1.0 null GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78355 SRPRB Pathway Commons Protein-Protein Interactions 1.0 null GTEX-WL46-0011-R5A-SM-3LK6V GTEx Tissue Sample Gene Expression Profiles 1.0 1.09779 H3K23ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 2561_EIF4A3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.988154 PYCR2 Pathway Commons Protein-Protein Interactions 1.0 null GSE242290_1_v_0_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null HUP-T4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.97037 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8046-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UPK5-0006-SM-3GAD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.880954 Kidney Chromophobe_KICH_TCGA-KM-8476-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.1945 EPB41L1 Pathway Commons Protein-Protein Interactions 1.0 null E2F1 ENCODE Transcription Factor Targets 1.0 null head of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.47079 H4K91ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RPS23 Pathway Commons Protein-Protein Interactions 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A41B-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HNF4A ChEA Transcription Factor Targets 1.0 null H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XMK1-1726-SM-4B64Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.1537 GSE222758_0_v_3_clofazimine_human RummaGEO Drug Perturbation Signatures -1.0 null AE-85-KE62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.226445 U2SURP Pathway Commons Protein-Protein Interactions 1.0 null BRD-K23075656 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02686 A549_Sodium Phenylbutyrate_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150339 MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.947275 MTMR3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00739883 primary auditory cortex (core)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.87639 PBX3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CUX1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EW1 DepMap CRISPR Gene Dependency 1.0 2.18097 GTEX-WWYW-0011-R6A-SM-3NB3G GTEx Tissue Sample Gene Expression Profiles 1.0 0.852262 LSM7 Pathway Commons Protein-Protein Interactions 1.0 null CHD7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Arcuate hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30277 GTEX-VUSG-2726-SM-4KKZJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.48914 Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A654-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 105KC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.0191 DYNLL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48699 H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null artery TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null G28T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.20081 CRCGN008_HEPG2_24H:L14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3116 H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EXOSC5 Pathway Commons Protein-Protein Interactions 1.0 null AGBL1 Pathway Commons Protein-Protein Interactions 1.0 null Intercalated amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07642 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19T-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN009_HEPG2_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.07057 KRTAP4-11 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00649723 NMC-G1 GDSC Cell Line Gene Expression Profiles -1.0 -2.88343 IRF4 ENCODE Transcription Factor Targets 1.0 null MXI1 ENCODE Transcription Factor Targets 1.0 null ABCB7 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05133 Intracellular non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GTEX-WFG7-0005-SM-3GIKM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3588 SND1 Pathway Commons Protein-Protein Interactions 1.0 null PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Supplementary_Table_9A_The_effects_of_whole_blood_transcripts_on_COVID-19_severity_with_suggestive_Mendelian_randomization_evidence_P_0_05_using_Genomicc_data_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null MAX_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K27726273 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18776 BRD-K73831546 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60576 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WI4N-1126-SM-3LK7Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25447 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67W-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN008_HEPG2_24H:A04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.2874 HNRNPR Pathway Commons Protein-Protein Interactions 1.0 null PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_unique_ELK4 Rummagene Transcription Factor Associations 2026 1.0 null UBTF ENCODE Transcription Factor Targets 1.0 null GSE158834_10_v_8_palm_human RummaGEO Gene Perturbation Signatures -1.0 null adrenocortical carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.47755 SC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.64395 1941_CTPS1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.51733 SD-69-QA40_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.228952 JAK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01338 Perturb_1845_KO_Nos2_SRP371304 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.20957 MYC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210655_1_v_7_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE63048_11_v_8_morc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null TAL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NA-30-HS87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.06145 SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 9680_UTP14A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.546717 NELFE ENCODE Transcription Factor Targets 1.0 null LF-94-HB11_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.352241 BT474 CCLE Cell Line Gene CNV Profiles 1.0 2.07332 GTEX-P44H-1026-SM-3NM96 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04802 ATP5C1 Pathway Commons Protein-Protein Interactions 1.0 null GSE57871_11_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null K562_WP1066_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0167395 single-organism process GO Biological Process Annotations 2015 1.0 null connecting stalk TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MYC_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EN1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.9594 SERPINH1 Pathway Commons Protein-Protein Interactions 1.0 null LSM6 Pathway Commons Protein-Protein Interactions 1.0 null GSE193258,GSE193259_9_v_3_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null PHB2 Pathway Commons Protein-Protein Interactions 1.0 null MAX_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Small ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.927 CF-87-AS90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.219515 GSE233647_4_v_0_docetaxel_human RummaGEO Drug Perturbation Signatures -1.0 null corpus callosum Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.25238 r5 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18681 RPL35 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN012_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.06985 POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE145311_0_v_2_glutathione_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE196343_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null PMC10742386-pnas.2311372120.sd05.xlsx-DLX3_ST-Gene_Symbol_DLX3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XMD1-0011-R11A-SM-4AT5J GTEx Tissue Sample Gene Expression Profiles 1.0 1.15417 PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null Mitochondrial large ribosomal subunit COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 extracellular region LOCATE Predicted Protein Localization Annotations 1.0 null Entorhinal area, medial part, dorsal zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34547 PLS3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0054446 BRD-K02180800 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60515 POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CD-13-QZ32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.508662 GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.10097 SCC25 CCLE Cell Line Gene Expression Profiles 1.0 2.35869 SHMT2 Pathway Commons Protein-Protein Interactions 1.0 null FD-91-OK66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.27001 TCF7L2_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLIRP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44164 amygdaloid complex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.17306 ZC3H15 Pathway Commons Protein-Protein Interactions 1.0 null DA-83-IZ87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.566305 496100577_FWM_probable Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.31023 TMEM30B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67637 mitochondrial translational termination GO Biological Process Annotations 2015 1.0 null BRD-K10011427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55522 PBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.1667 Perturb_13968_KD_Ago2_ERP133202 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.21475 BRD-K39193666 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91917 NFE2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1PU-01A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WZTO-0011-R11A-SM-4E3K9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.93132 OAT Pathway Commons Protein-Protein Interactions 1.0 null GSE235587_2_v_1_mitoxantrone_human RummaGEO Drug Perturbation Signatures -1.0 null JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU2F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.8034 TRIM28 ENCODE Transcription Factor Targets 1.0 null BRD-K81568980 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74477 ASH2L ChEA Transcription Factor Targets 1.0 null KASUMI2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 3.04392 AD-40-WB93_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.265057 IGF2BP3 Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-7570-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.85567 GSE160001,GSE160670_0_v_2_lapatinib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K02946901 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.34527 ChIP_CNOT3_19339689 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null EE-08-SZ54_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.248616 levetiracetam_rattus norvegicus_gpl1355_brainstem_gds1864 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SK-MM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13801 PD-70-VS77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.541268 NCI-H1781 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.862715 GBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.0895 GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles -1.0 -2.18991 GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55327 MRPS30 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_13206_OE_Klf3_SRP281992 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.30159 GSE149621_0_v_1_olaparib_human RummaGEO Drug Perturbation Signatures -1.0 null RFC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.3513 HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 2120_DDX41_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.84461 H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.990761 MTA3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO680N CCLE Cell Line Gene CNV Profiles 1.0 1.78234 lateral hemisphere of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.54758 9656_USP39_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.765694 GTEX-P44H-0011-R11A-SM-2XCER GTEx Tissue Sample Gene Expression Profiles 1.0 0.895266 embryonic structure TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null JUND_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.03116 GSE143782_6_v_5_calcitriol_human RummaGEO Drug Perturbation Signatures -1.0 null GM1600 BioGPS Cell Line Gene Expression Profiles -1.0 -1.42067 orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.125 amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.55587 Mitochondrial respiratory chain complex I COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.052 MYC_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BICR22 CCLE Cell Line Gene CNV Profiles -1.0 -1.70915 BRD-K80807286 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13956 UQCC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0744 OE-18-ZX28_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.216434 Prostate BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.18295 H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC6225799-annrheumdis-2018-213524supp003.xlsx-Activated-state-LPS-Gene_Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null EVX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.6381 reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052232 CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LD-69-ZV56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.83039 Perturb_50_KO_Kat6a_SRP215863 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.32446 H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RBBP4 Pathway Commons Protein-Protein Interactions 1.0 null GSE168797_4_v_3_cannabidiol_human RummaGEO Drug Perturbation Signatures -1.0 null Primary somatosensory area, barrel field, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02345 E2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.918791 BRD-K95712112 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17736 medial geniculate complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.68188 Perturb_1846_KO_Nox2_SRP371304 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.38868 organic substance biosynthetic process GO Biological Process Annotations 2015 1.0 null GTEX-T5JW-0005-SM-3GADE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.79237 GTEX-VJWN-0005-SM-3GIKF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09432 P2RY8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00563601 RAB3IL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39822 GSE149124,GSE149128_3_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null VDR-23849224-CD4+-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null 15843827-TableS6 GeneSigDB Published Gene Signatures 1.0 null DDX21 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN011_HEPG2_24H:E11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.02275 gdm1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.883 SARS-CoV NSP16_Day4_None_GSE49263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.48514 JARID1A-20064375-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62777 TRPS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4836 pyramidal cells of caudal CA4 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.831282 Large ribosomal subunit COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GTEX-XBED-0926-SM-48TCE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.954523 RUNX1-27514584-CHIP-SEQ-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M8-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10769395-media-2.xlsx-S2E_EF_Activated_genes-Ebegboni_et_al_Supplemental_Table_S2E_Decreased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null K562_Pirarubicin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0165181 MDAMB175VII Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -2.33194 BRD-K86358396 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59332 GSE248858_6_v_0_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null principal sensory nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01029 BRD-K45916030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24707 HNF4A-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null MKN-45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.46458 BRD-K56520977 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06355 hsa-miR-4482 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 5762_NPAT_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.709657 H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Perturb_2037_KO_Arhgef2_SRP217239 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.02309 ventrolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.05124 UBAC2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00501654 Retrosplenial area, ventral part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14514 UQCRC1 Pathway Commons Protein-Protein Interactions 1.0 null BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.907133 GTEX-XAJ8-1226-SM-47JYS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.8528 BRD-K38858314 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10683 KCNQ2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29704 RCC10RGB Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.43462 Uterine leiomyoma_Uterus - Myometrium (MMHCC)_GSE593 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 3.3185 GSE111660_2_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A6UO-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Inclusion Body Myositides_Muscle tissue_GSE3112 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.79065 mesoderm TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SLC3A2 Pathway Commons Protein-Protein Interactions 1.0 null Entorhinal area, lateral part, layer 2a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.69117 GABPA_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Dasatinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0119909 Posterolateral visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59502 H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Respiratory chain complex I COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.861 BRD-K51898276 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41133 KYSE180 DepMap CRISPR Gene Dependency 1.0 2.08351 ZZZ3 ENCODE Transcription Factor Targets 1.0 null H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TCF12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_3112_KO_Ptpdc1_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.36796 TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRPS18A Pathway Commons Protein-Protein Interactions 1.0 null Rectum adenocarcinoma_READ_TCGA-DY-A1H8-01A-21R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100596_FWM_dementia_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.84556 ELOA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10335 GTF2F1 ENCODE Transcription Factor Targets 1.0 null ZBTB33_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Zic2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.0701 GTEX-WL46-0011-R2A-SM-3LK6O GTEx Tissue Sample Gene Expression Profiles 1.0 1.22706 Sensorineural hearing loss DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.027 FLI1::DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9041 GSE178714_1_v_4_smad2_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K54576503 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25471 Bed nuclei of the stria terminalis, anterior division, oval nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24892 RT-112 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.04621 Perturb_6015_KD_FYTTD1_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE152699,GSE152723_0_v_1_vemurafenib_human RummaGEO Drug Perturbation Signatures -1.0 null 16207381-Table1Sa GeneSigDB Published Gene Signatures 1.0 null 451LU COSMIC Cell Line Gene CNV Profiles 1.0 2.49065 BRD-K72675584 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23226 GTEX-PVOW-0006-SM-3NMB8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40813 ELF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATP5D Pathway Commons Protein-Protein Interactions 1.0 null BW-B70C-1132 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE157609,GSE158123_0_v_1_ifi16_human RummaGEO Gene Perturbation Signatures -1.0 null ARRDC5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00649924 GTEX-X8HC-1626-SM-46MWE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02018 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null biosynthetic process GO Biological Process Annotations 2015 1.0 null CCRF-CEM Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.62612 GSE157233_2_v_4_a1cf_mouse RummaGEO Gene Perturbation Signatures -1.0 null MRPL43 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-R53T-1326-SM-48FCQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.1773 RAD21_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_14809_OE_Ldah_SRP282425 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 FOXP3-21729870-TREG-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Perturb_3079_KO_Dlue7_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.30242 Acute Myeloid Leukemia_LAML_TCGA-AB-2904-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFYA JASPAR Predicted Transcription Factor Targets 1.0 null H3K79me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null C10orf2 Pathway Commons Protein-Protein Interactions 1.0 null Secondary motor area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.81366 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE200673,GSE200691_1_v_3_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE182680,GSE182683_7_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null PMC12697907-ADVS-12-e07451-s002.xlsx-ST4F_MR-pan-cancer-out-Unnamed_2_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GSE70499_5_v_1_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null RUNX1-27514584-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 CYP11A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0062782 YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.654 Pancreatic adenocarcinoma_PAAD_TCGA-OE-A75W-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.WT.HP_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.14495 GTEX-VUSG-0003-SM-3NMDK GTEx Tissue Sample Gene Expression Profiles 1.0 1.01034 POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55C-0726-SM-48FCN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.859595 TAF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA3 ENCODE Transcription Factor Targets 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A5U2-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.913292 DF-00-BX35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.612415 Adrenocortical carcinoma_ACC_TCGA-OR-A5J1-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SFXN1 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_3108_KO_Pate2_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.44988 BRD-K94082609 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91477 GTEX-P4QS-1626-SM-2S1NH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.871306 Perturb_8403_KD_Safb_SRP234723 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.17957 r5 part of the cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26383 GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17477 GTEX-R3RS-0005-SM-3GAEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01217 TOX4 Pathway Commons Protein-Protein Interactions 1.0 null Ribosomal subunit COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A34891365 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40226 GTEX-WL46-0011-R1A-SM-3LK6M GTEx Tissue Sample Gene Expression Profiles 1.0 1.17978 39S ribosomal subunit, mitochondrial CORUM Protein Complexes 1.0 null SP1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null r7 part of the posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.94772 PRMT1 Pathway Commons Protein-Protein Interactions 1.0 null intermediate stratum of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15012 MCF7_Ofloxacin_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0132224 ventral medial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.827968 Leigh disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.302 PFKL_OE_GDS1079_201_mouse_myoblasts GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K06219419 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21992 GSE232564,GSE232566_0_v_2_nsd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null r10 part of the trigeminal column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02254 BRD-K84761515 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00229 Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SF-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QK-01B-11R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOS ENCODE Transcription Factor Targets 1.0 null YBX1 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K21635266 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22518 Primary somatosensory area, lower limb, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.8584 CRCGN011_HEPG2_24H:I19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.20305 Perturb_14041_KO_Mbd1/Mbd2/Mbd4/Mecp2_SRP337936 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.46707 membrane-enclosed lumen COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 BRD-K09699976 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05012 GSE216043_11_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null 501A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30866 RELL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00733653 Adrenocortical carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.431 GSE87299_2_v_3_nr1d1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN014_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.2252 GTEX-X5EB-1826-SM-4E3K8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.922943 GTEX-PWN1-1826-SM-2S1PE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.943568 RAD21 ENCODE Transcription Factor Targets 1.0 null ACOT9 Pathway Commons Protein-Protein Interactions 1.0 null GSE211744_7_v_0_gdf15_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN013_HEPG2_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.00772 HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39075 IRF4_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HSPA9 Pathway Commons Protein-Protein Interactions 1.0 null LEF1-29337183-MESC-MOUSE-STEM ChEA Transcription Factor Targets 2022 1.0 null macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.044684 BRD-K68618894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4896 BRD-K36997940 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56579 GTEX-UPJH-0006-SM-3GACW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00117 GSTA4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00581976 TAF7_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A_48H:L19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.03479 MRPL14 Pathway Commons Protein-Protein Interactions 1.0 null limbic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.091647 H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null TMEM106A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18725 intracellular organelle lumen COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 EP300-20729851-FORBRAIN_MIDBRAIN_LIMB_HEART-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.07064 HIST1H1D Pathway Commons Protein-Protein Interactions 1.0 null GSE149264,GSE149267_9_v_1_trp53_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRCA1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLI1_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE95685_2_v_0_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null CHD7 ENCODE Transcription Factor Targets 1.0 null inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.826253 intracellular non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.078148 POLR2B Pathway Commons Protein-Protein Interactions 1.0 null ASH2L-23239880-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CDC25C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.005688 Mitochondrion COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.22486 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.77736 FBL Pathway Commons Protein-Protein Interactions 1.0 null SRPR Pathway Commons Protein-Protein Interactions 1.0 null GTEX-PSDG-0005-SM-3GADC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827497 GOLGA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13111 HOXC9-25013753-NEUROBLASTOMA-BE2-C-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE147240_3_v_6_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE102598_1_v_2_nmda_mouse RummaGEO Drug Perturbation Signatures 1.0 null Perturb_3081_KO_Dock11_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.83997 POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.40377 GTEX-S7PM-0006-SM-3NM8C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15448 Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A4U1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K26704304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74198 GSE197686,GSE197688_2_v_0_arid1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null AF-67-LZ82_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.312917 H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ELK1 ENCODE Transcription Factor Targets 1.0 null SNU1079 CCLE Cell Line Gene CNV Profiles 1.0 1.44438 POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null DLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.5499 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 308_ANAPC4_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.604701 GSE211744_8_v_5_gdf15_mouse RummaGEO Gene Perturbation Signatures -1.0 null cellular protein complex disassembly GO Biological Process Annotations 2015 1.0 null central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.886981 GTEX-SNOS-0003-SM-3NMAO GTEx Tissue Sample Gene Expression Profiles 1.0 1.1184 FC-20-EQ58_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.218585 striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.83966 CAMA1 CCLE Cell Line Gene CNV Profiles -1.0 -1.81986 BRD-K39498165 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17029 RPS25 Pathway Commons Protein-Protein Interactions 1.0 null ATF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.9734 KHM1B CCLE Cell Line Gene Expression Profiles 1.0 2.34025 PRDX4 Pathway Commons Protein-Protein Interactions 1.0 null CB-16-SY72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.233079 S100A12 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00497727 RBM39 Pathway Commons Protein-Protein Interactions 1.0 null RARS2 Pathway Commons Protein-Protein Interactions 1.0 null sublayer 6b of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02787 GSE193258,GSE193259_9_v_12_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE195568_1_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null DKMG CCLE Cell Line Gene Expression Profiles -1.0 -1.70186 translation GO Biological Process Annotations 2015 1.0 null CDC5L Pathway Commons Protein-Protein Interactions 1.0 null BA-39-OX47_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20986 BF-10-IO69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.337691 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null MYC_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARHGEF39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20209 Inferior olivary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.26662 POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Somatomotor areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25623 APC2 Pathway Commons Protein-Protein Interactions 1.0 null Secondary motor area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35043 vascular system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null AA-62-OC45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.989218 K562_2-Methoxyestradiol_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160102 POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOXB2::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.3336 H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TEAD4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRSF5 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4154-01A-01R-1188-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Urinary bladder TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 15735024-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null RPL22 Pathway Commons Protein-Protein Interactions 1.0 null Prostate adenocarcinoma_PRAD_TCGA-FC-A6HD-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FLO1 DepMap CRISPR Gene Dependency 1.0 2.03937 FOXL1 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K11113009 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17537 DAP3 Pathway Commons Protein-Protein Interactions 1.0 null A549_Amisulpride_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160717 BRD-K68617666 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4518 H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Organellar ribosome COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 NFIC_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOXB7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.8978 H3K79me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056509 H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RU72-0011-R9A-SM-2TF67 GTEx Tissue Sample Gene Expression Profiles 1.0 0.98935 GSE209898,GSE209899_0_v_1_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2 Rummagene Transcription Factor Associations 2026 1.0 null MAZ ENCODE Transcription Factor Targets 1.0 null GM97 BioGPS Cell Line Gene Expression Profiles -1.0 -2.7446 EIF3G Pathway Commons Protein-Protein Interactions 1.0 null pyramidal cells of rostral CA4 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07695 HOXB4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.6879 EBF1 ENCODE Transcription Factor Targets 1.0 null HOXB3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.2767 GSE201217_2_v_1_usf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null fallopian tube HPA Tissue Gene Expression Profiles 1.0 1.20028 GSE225218_8_v_3_abcb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_12537_KO_Pkd1_SRP388451 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.63814 SRSF3 Pathway Commons Protein-Protein Interactions 1.0 null GSE195568_6_v_0_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GA-10-WX15_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.298707 rostral subdivision of medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.899801 fluoxetine_mus musculus_gpl1261_gse35761 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null r3 part of medial pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.8584 PLCL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00513963 GSE200352_5_v_8_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_13748_KO_Pum1/Pum2_SRP100512 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.80311 GTEX-XMD1-0011-R8A-SM-4AT48 GTEx Tissue Sample Gene Expression Profiles 1.0 1.1817 RARS Pathway Commons Protein-Protein Interactions 1.0 null BRD-K08431704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5615 YY1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal lateral geniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50105 XC-81-LR46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.201703 RPL26L1 Pathway Commons Protein-Protein Interactions 1.0 null Chloroplast ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.634 organelle inner membrane GO Cellular Component Annotations 2015 1.0 null GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46673 Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A61V-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE115395_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null TCF7L2 ENCODE Transcription Factor Targets 1.0 null EA-93-KT88_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.26652 GM133 BioGPS Cell Line Gene Expression Profiles -1.0 -0.873041 KPNB1 Pathway Commons Protein-Protein Interactions 1.0 null ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.54971 HA-E2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE120612_7_v_3_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_3121_KO_Slc45a3_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.59539 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null F5 CCLE Cell Line Gene Expression Profiles -1.0 -2.21752 cingulate gyrus, parietal part, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.09491 POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYCN-27167114-CHIP-SEQ-NEUROBLASTOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K76661445 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22457 K562_ITSA-1_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016197 abnormal circulating creatinine level GWASdb SNP-Phenotype Associations 1.0 0.654545 primary motor cortex (area M1, area 4)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.14168 outer SZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.36828 RPL21 Pathway Commons Protein-Protein Interactions 1.0 null GTL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.829143 A549_Barasertib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.018914 SK-N-AS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.897483 SP1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null USF2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.91827 SETDB1 ENCODE Transcription Factor Targets 1.0 null ChIP_TRIM28_19339689 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null MDAMB415 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.830135 CA1 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.16648 CHD3 Pathway Commons Protein-Protein Interactions 1.0 null SLC25A13 Pathway Commons Protein-Protein Interactions 1.0 null central nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.995659 EPLC272H CCLE Cell Line Gene Expression Profiles 1.0 1.61749 H3K4me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K45979235 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44521 BRD-K19161227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24423 CRCGN009_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3528 GSE137144_5_v_6_nlrp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE151612_0_v_8_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE120612_6_v_0_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null AB-04-NN16_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20627 PMC10274745-media-4.xlsx-S3B-Table_S3_Reanalysis_of_publicly_available_data_to_identify_AR_and_ER_direct_target_genes_related_to_Figure_1_AR Rummagene Transcription Factor Associations 2026 1.0 null SNU-387 GDSC Cell Line Gene Expression Profiles 1.0 1.73882 rostral putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.26625 MYC-19079543-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GD-59-OG21_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.319642 CRCGN012_HEPG2_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06933 NB7 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.24717 Infertility, Female CTD Gene-Disease Associations 1.0 1.11081 GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64087 STAT3 MotifMap Predicted Transcription Factor Targets 1.0 null GSE138945,GSE138947_0_v_1_mboat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null SP1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-CoV_96Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.2014 EIF3K Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Ramelteon_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0165716 H3K27ac_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NEC8 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.8455 PMC3500769-srep00875-s3.xls-CEBP-Time_1_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39Y-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC ChEA Transcription Factor Targets 1.0 null mitochondrial translational elongation GO Biological Process Annotations 2015 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5326-01A-01R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HS255T CCLE Cell Line Gene Expression Profiles -1.0 -1.7803 r9 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19864 organellar ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.900426 DDX3X Pathway Commons Protein-Protein Interactions 1.0 null FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Senescence_CNS - Brain - Hippocampus (MMHCC)_GSE5078 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.50794 ED-05-LQ40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.668671 PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null GSE135030_8_v_7_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE149264,GSE149267_9_v_3_trp53_mouse RummaGEO Gene Perturbation Signatures -1.0 null TFEB-21752829-HELA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Leukemia_promyelocytic-HL-60 BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.33011 KF-18-RY71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.230352 GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.68893 GSE249893_1_v_0_tfam_mouse RummaGEO Gene Perturbation Signatures -1.0 null EC-01-PH79_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.265115 FB-39-CW59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.733648 Perturb_14232_Mut_Dpagt1_SRP230444 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 U87 BioGPS Cell Line Gene Expression Profiles -1.0 -1.13655 Prostate adenocarcinoma_PRAD_TCGA-KK-A59X-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH211 CCLE Cell Line Gene CNV Profiles 1.0 1.42071 CEBPB_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDX2-20551321-CACO-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE62843,GSE64371_4_v_3_furan_mouse RummaGEO Drug Perturbation Signatures -1.0 null mRNA_TCF3_20139965 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null Perturb_14040_KO_Mbd1/Mbd2/Mbd4/Mecp2_SRP337936 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.44007 GTEX-QLQ7-1526-SM-2S1QA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.98852 IZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.849309 BRD-K79303560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03061 Perturb_3101_KO_Mid2_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.77289 S117 CCLE Cell Line Gene CNV Profiles -1.0 -1.59617 gracile nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.883474 YY1-23942234-MYOBLASTS AND MYOTUBES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null HOXA7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.2169 PMC3500769-srep00875-s3.xls-CEBP-Time_4_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null QF-71-QI30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.517878 BRD-K13715646 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0596 GSE248858_6_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures 1.0 null THNSL1 Pathway Commons Protein-Protein Interactions 1.0 null GSE246660_1_v_0_glycerol_human RummaGEO Drug Perturbation Signatures -1.0 null U-698-M GDSC Cell Line Gene Expression Profiles 1.0 1.6571 DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.47223 BRD-K18984088 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22022 TAF1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SF-2226-SM-3K2BG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16556 CPT1A Pathway Commons Protein-Protein Interactions 1.0 null SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEL4-0826-SM-3GAF2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.837585 NOA1 Pathway Commons Protein-Protein Interactions 1.0 null GSE160083,GSE160084_1_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.98719 EIF4G1 Pathway Commons Protein-Protein Interactions 1.0 null RBM14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05314 RPS9 Pathway Commons Protein-Protein Interactions 1.0 null ESRRA ENCODE Transcription Factor Targets 1.0 null BA-84-TD72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.391799 FD-20-OG99_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.408771 K562_Gandotinib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0164531 medial (main) part of Med Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04995 Perturb_15664_KD_Srsf1_SRP313287 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.59905 H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_3097_KO_Lama4_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.38282 lymphnode_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.00232 MOG-G-UVW Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.41537 HOXA6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.0991 posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.02775 CC-49-CQ25_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.681292 SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.06393 GTEX-T5JC-0001-SM-3NMAK GTEx Tissue Sample Gene Expression Profiles 1.0 0.964475 SART1 Pathway Commons Protein-Protein Interactions 1.0 null LTA4H LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00416539 Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y8-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EXT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00468657 ZFAND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37382 OC-71-BZ81_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.238541 C14orf166 Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Amisulpride_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0155237 978_C14ORF178_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.513318 REST_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WQUQ-0006-SM-3MJF4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10437 NR4A1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6815 K562_PCI-34051_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0166891 H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null cardiovascular system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null LN319 CCLE Cell Line Gene Expression Profiles -1.0 -1.54325 EOMES-20176728-TSCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null mitochondrion COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 BRD-K06431647 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48504 GTEX-T5JC-0011-R8A-SM-32PLM GTEx Tissue Sample Gene Expression Profiles 1.0 0.857734 CRCGN013_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.33551 SFPQ Pathway Commons Protein-Protein Interactions 1.0 null GSE168458_1_v_3_disulfiram_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TUBB Pathway Commons Protein-Protein Interactions 1.0 null CHD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JAK2_activemutant_178_GSE44961 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.57571 THOC7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48603 ZBTB33_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBEC-1326-SM-4AT69 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27616 Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A767-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE93309_1_v_4_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NHP2L1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-R55E-2526-SM-2TC6H GTEx Tissue Sample Gene Expression Profiles 1.0 1.41563 GSE248045,GSE248046_6_v_1_runx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC3500769-srep00875-s3.xls-GATA3-Time_0_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null TFAM Pathway Commons Protein-Protein Interactions 1.0 null CREB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE172146_2_v_0_mettl1_human RummaGEO Gene Perturbation Signatures 1.0 null 7608_RUVBL2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.583968 BE-81-QL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.292369 BRD-K91268803 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41659 GTEX-T6MO-0003-SM-3NMAG GTEx Tissue Sample Gene Expression Profiles 1.0 1.48365 oculomotor nuclear complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.42373 Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.16174 REST_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_15320_OE_Nrf1_SRP298724 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.32858 RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWS6-1326-SM-47JXB GTEx Tissue Sample Gene Expression Profiles 1.0 0.890443 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E3-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1-23762244-HIPPOCAMPUS-RAT ChEA Transcription Factor Binding Site Profiles 1.0 null 496100590_FWM_probable Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.07453 RPL7 Pathway Commons Protein-Protein Interactions 1.0 null PPP1CA Pathway Commons Protein-Protein Interactions 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02929 EHHADH Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_4988_KO_Ythdc1_SRP212677 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.84382 BRD-K44509164 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72922 GB-73-QS80_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.410012 YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K51185182 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20374 LBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0276 TEAD4_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRPL9 Pathway Commons Protein-Protein Interactions 1.0 null cerebellum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.984483 BRD-K93993174 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34282 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null sublayer 6b of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29903 AP2A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.623 CRCGN011_HEPG2_24H:D04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1525 CAMLG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42513 MRPS5 Pathway Commons Protein-Protein Interactions 1.0 null inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.02392 BRD-K99036206 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.482 H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE115542_5_v_1_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null primary motor-sensory cortex (samples)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.20525 GSE95685_4_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null BRD-K07762528 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18422 COLO205 BioGPS Cell Line Gene Expression Profiles 1.0 1.51874 PRECLH CCLE Cell Line Gene Expression Profiles -1.0 -2.35686 SRSF11 Pathway Commons Protein-Protein Interactions 1.0 null GABPA_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PDGFRA_knockdown_117_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.97853 NFIA_Deficiency_GDS2775_639_mouse_Embryonic brains (at E18) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null TE-15 COSMIC Cell Line Gene CNV Profiles 1.0 2.49065 PMC10641274-mmc2.xlsx-FOXK1_Untreated-SYMBOL_FOXK1 Rummagene Transcription Factor Associations 2026 1.0 null H3K79me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AG-0011-R2A-SM-2HMIT GTEx Tissue Sample Gene Expression Profiles 1.0 1.78271 FARAGE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03927 BRD-K72501910 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13218 GTF3C2 ENCODE Transcription Factor Targets 1.0 null DA-10-HD17_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.251708 BRD-K92579151 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3958 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4075-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TIG3TD CCLE Cell Line Gene Expression Profiles -1.0 -1.47037 striatum_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.20608 GC-04-UF36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.783205 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_11_ZZZ3_ChIP-seq_in_shZZZ3-Nearest_TSS_ZZZ3 Rummagene Transcription Factor Associations 2026 1.0 null KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_191_KO_Phgdh_SRP363494 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.45355 SNRPB2 Pathway Commons Protein-Protein Interactions 1.0 null H3K79me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XOTO-0011-R11B-SM-4B64O GTEx Tissue Sample Gene Expression Profiles 1.0 1.30342 BRD-K35560933 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3021 periventricular stratum of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.67397 CRCGN015_HEPG2_48H:L20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.27266 REST_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null DPY30 Pathway Commons Protein-Protein Interactions 1.0 null RBFA Pathway Commons Protein-Protein Interactions 1.0 null Perturb_12137_OE_Wdr11_SRP113332 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.50193 LSG1 Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6020-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE211744_8_v_0_gdf15_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K06310280 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66884 BRD-K66748326 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47429 H3K9ac_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ILF3 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRPL41 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-WWYW-0005-SM-3NB3K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34728 MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LARP4 Pathway Commons Protein-Protein Interactions 1.0 null TRPM7_defectivemutant_306_GSE23102 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.96091 intracellular organelle GO Cellular Component Annotations 2015 1.0 null Weight Loss CTD Gene-Disease Associations 1.0 1.04794 BRD-K25600773 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30689 HOXA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.5056 Urinary tract TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 inner CP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07488 PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null FBXO42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36446 SKMEL30 CCLE Cell Line Gene CNV Profiles 1.0 1.5581 BRD-K80166820 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.21309 PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-942 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 NRF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPV-0006-SM-2TF6Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13046 thyroid GTEx Tissue Gene Expression Profiles 1.0 0.82691 GB-84-KP45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.597074 KC-32-GO33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.299853 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3328-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE95688_7_v_2_glutathione_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE124410_2_v_4_stk40_mouse RummaGEO Gene Perturbation Signatures -1.0 null CD300LG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00711149 BRD-K96637144 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16181 BICR31 CCLE Cell Line Gene CNV Profiles 1.0 1.89093 CREB1 ChEA Transcription Factor Targets 1.0 null MRPS26 Pathway Commons Protein-Protein Interactions 1.0 null ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.198325 CAMA1 CCLE Cell Line Gene Expression Profiles -1.0 -1.73105 BFTC-905 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.966978 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K28785305 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.73679 PHF5A Pathway Commons Protein-Protein Interactions 1.0 null SURF1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-RU1J-0226-SM-2TF5Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.827275 BRD-K25942808 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08275 BRD-K03662481 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45214 GTEX-NL4W-0011-R11A-SM-2I3DW GTEx Tissue Sample Gene Expression Profiles 1.0 2.50234 non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.075605 PMEPA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00564392 GSE112174_5_v_7_runx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null EIF3D Pathway Commons Protein-Protein Interactions 1.0 null PMC9307901-mmc2.xlsx-S5-GATA6-AS1_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null SKMM2 CCLE Cell Line Gene CNV Profiles 1.0 1.49089 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.41475 H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AASS Pathway Commons Protein-Protein Interactions 1.0 null MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.54478 K562_Aurora A Inhibitor I_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151844 BRD-A31962514 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84383 CHD2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DLD Pathway Commons Protein-Protein Interactions 1.0 null GSE179138_4_v_1_lama4_mouse RummaGEO Gene Perturbation Signatures -1.0 null ECH1 Pathway Commons Protein-Protein Interactions 1.0 null SIN3A ENCODE Transcription Factor Targets 1.0 null H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_HEPG2_48H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.39838 BAD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02983 MRPL32 Pathway Commons Protein-Protein Interactions 1.0 null CEBPD ENCODE Transcription Factor Targets 1.0 null ribonucleoprotein complex GO Cellular Component Annotations 2015 1.0 null Perturb_12856_OE_Eif2a_SRP306641 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.3779 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H3-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_6059_KD_RBM26_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 RPS10 Pathway Commons Protein-Protein Interactions 1.0 null KAT2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PSKH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.55992 blood vessel GTEx Tissue Gene Expression Profiles -1.0 -0.935196 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WHPG-0006-SM-3NMBV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.992078 H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null bladder TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SP1 ENCODE Transcription Factor Targets 1.0 null BRD-K83892314 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02647 intracellular organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Umbilical cord blood TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Brain Lower Grade Glioma_LGG_TCGA-S9-A7R2-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKMEL2 CCLE Cell Line Gene CNV Profiles -1.0 -2.06384 APLF Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.945319 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K57202089 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57985 BRD-K32856496 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23582 BRD-K83786559 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.66281 DA-27-BW20_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.627725 raphe obscurus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.839289 RPLP1 Pathway Commons Protein-Protein Interactions 1.0 null GSE120413,GSE120447_0_v_2_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.686486 PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1 Rummagene Transcription Factor Associations 2026 1.0 null HCV JFH-1_18Hour_20200238_GSE20948 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.71042 GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -3.81606 HIST1H1B Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null macromolecular complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-UTHO-0011-R4A-SM-3GIJP GTEx Tissue Sample Gene Expression Profiles 1.0 1.30397 UBF1/2-26484160-CHIP-SEQ-HMECS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null UFL1 Pathway Commons Protein-Protein Interactions 1.0 null HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05628 sublayer 6a of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23216 H3K4me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RL CCLE Cell Line Gene Expression Profiles 1.0 1.63589 superficial stratum of r7BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.83379 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E8-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM98B Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null PTK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00312836 SRSF4 Pathway Commons Protein-Protein Interactions 1.0 null POLR2AphosphoS5_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null laudanosine-1741 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K66590796 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19146 GSE205316,GSE205317_2_v_1_nrip1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K29652917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17177 EIF3I Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K56618252 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01851 lateral tuberal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.881127 GTEX-X4EO-0006-SM-3P5ZF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51083 RPL38 Pathway Commons Protein-Protein Interactions 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-H4-A2HQ-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null AR-20517297-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC3500769-srep00875-s3.xls-PAX2-Time_0_PAX2 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_5143_KO_Ring1B_ERP008873 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.11024 HOP92 BioGPS Cell Line Gene Expression Profiles -1.0 -1.22556 BRD-K51937785 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57223 BRD-K42809349 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25368 H3K27ac_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RNOR-0011-R9A-SM-2TF52 GTEx Tissue Sample Gene Expression Profiles 1.0 0.901677 PMC4335056-pone.0116726.s005.xlsx-X-ChIP_NOT_TX100_QE-GENE_Official_symbol_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null LGE-VZ border region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.34907 DB CCLE Cell Line Gene Expression Profiles 1.0 1.89788 BRD-K03606830 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19788 3634_HAUS1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.578988 ETS1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32479 RTCA Pathway Commons Protein-Protein Interactions 1.0 null RFX5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7186_RBMX2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.526155 CRCGN017_MCF10A.WT.HP_24H:O18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.36725 Perturb_285_KD_GPD1L_SRP303690 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 H2BK12ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Mitochondrion CM4AI U2OS Cell Map Protein Localization Assemblies 1.0 null BATF ENCODE Transcription Factor Targets 1.0 null SMC3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of APal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57249 Perturb_8498_OE_Sox9_SRP375106 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.19071 GTEX-QVJO-0011-R5A-SM-2S1QM GTEx Tissue Sample Gene Expression Profiles 1.0 0.944628 GTEX-RTLS-0006-SM-2TF58 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78347 superficial stratum of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.26614 H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-NJ-A4YF-01A-12R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K65725294 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09318 MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ME-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08156 H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-1184 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 CRCGN013_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1537 CRCGN017_MCF10A.WT.HP_24H:L22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.0325 BRD-K35347834 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30978 TCF7-22412390-EML-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K73577714 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47881 2291_DNAJC17_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.673024 GSE77108_4_v_1_saha_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN017_MCF10A.TP53.M_24H:H16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.30265 H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.027 PMC8173714-NIHMS1678410-supplement-Supplementary_Table_2.xls-OfficialIPEXsig-Supplementary_Table_2_-_IPEX_signature_genes_with_their_average_IPEX_HD_fold_change_in_Tregs_and_Tconvs_FOXP3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-REY6-0126-SM-48FDT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.973205 RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GB-46-CK08_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.245301 BB65-RCC GDSC Cell Line Gene Expression Profiles -1.0 -1.4517 primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.2624 inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.30528 POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06225 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ND-54-NO97_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.204767 SSH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5984 K562_Toremifene Citrate_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0168873 GSE112860_5_v_7_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SRF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FC-22-VC55_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.311272 ND-15-RC31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.53216 hsa-miR-4777-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4816_KO_Apex1_SRP193096 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.76241 BRD-K08458391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10011 GSE158834_7_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_1123_KO_Myc_SRP168941 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.4421 MRPL19 Pathway Commons Protein-Protein Interactions 1.0 null PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A Rummagene Transcription Factor Associations 2026 1.0 null GSE122067_2_v_1_mtch2_mouse RummaGEO Gene Perturbation Signatures -1.0 null SNRPD3 Pathway Commons Protein-Protein Interactions 1.0 null superficial stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.00534 6792_PRPF19_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.713497 HIPK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77327 TMEM223 Pathway Commons Protein-Protein Interactions 1.0 null TGFB1I1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00624723 RBM26 Pathway Commons Protein-Protein Interactions 1.0 null Fundus of striatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14112 CE-23-HP88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.307095 Aedesalbopictus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.149 H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lung BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.2111 GSE172494_3_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null OLR1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0088379 CD-35-BD44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.437546 GSE186287_2_v_0_ufm1_human RummaGEO Gene Perturbation Signatures 1.0 null Lymphoma_burkitts(Daudi) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.2603 YMB1 CCLE Cell Line Gene CNV Profiles -1.0 -1.50117 PGR-26153859-MCF-7-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null BRD-K55256232 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28925 RPS13 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null COLO 201 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.32848 SLC8A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05627 CDK5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32432 PMC4728380-ncomms10153-s11.xlsx-Seitz_Burkitt-SEITZ_MYC_TARGETS_BURKITT_MYC Rummagene Transcription Factor Associations 2026 1.0 null REST_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K94692455 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31358 H3K4me1_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Neurological pain disorder_CNS - Spinal Cord (MMHCC)_GSE18803 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -0.797763 III, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.95667 primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.24247 oculomotor nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.47403 NDUFS2 Pathway Commons Protein-Protein Interactions 1.0 null RPS15 Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_14231_KO_Dpagt1_SRP230444 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -9.80846 SRSF2 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_11829_KO_Pxdc1_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.47656 3050_FDPS_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.500548 Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 BT474 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.94383 EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_12129_KO_IslandsH/Lipsi/Sfaktiria_SRP136181 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.21576 NARS2 Pathway Commons Protein-Protein Interactions 1.0 null WE-48-PP43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.661049 PMC10279693-41389_2023_477_MOESM3_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_15_MYC Rummagene Transcription Factor Associations 2026 1.0 null BRD-K32019201 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28237 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IK-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE196540,GSE196542_4_v_0_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null TEFM Pathway Commons Protein-Protein Interactions 1.0 null KIAA0391 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K11476310 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77014 Perturb_3089_KO_Fkbp5_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.47684 10478_ZNF585A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.555867 Perturb_4711_KO_Sox9_ERP109172 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.25237 POU2F2_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MOR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.862691 supraoptic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.07009 icSARS CoV_60Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.09006 E2F1-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null mediodorsal nucleus of thalamus_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19707 GSE143643,GSE143644_2_v_0_hdac3_mouse RummaGEO Gene Perturbation Signatures -1.0 null MARK2 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_16856_KO_Hnrnph1_SRP068520 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 11.2669 REST_Panc1_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CF-24-KQ98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.25158 EP300_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null C19orf53 Pathway Commons Protein-Protein Interactions 1.0 null CE-18-CG29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.229948 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051182 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.11 Lung squamous cell carcinoma_LUSC_TCGA-37-4132-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null striatum_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.982187 RTN4IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11224 Bed nuclei of the stria terminalis, posterior division, strial extension Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22176 SRF_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null bed nucleus of the stria terminalis, laterocentral division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31224 PMC8497824-Table_4.xlsx-Stage_4_EOMES_vs_Ctrl-Unnamed_1_EOMES Rummagene Transcription Factor Associations 2026 1.0 null B-CPAP Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.98266 anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.2551 POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04157 CRCGN008_HEPG2_24H:G24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.63685 hsa-miR-3130-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 BRD-K31898235 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33809 CBR3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00388605 ATF1 ENCODE Transcription Factor Targets 1.0 null ATMIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79261 Primary somatosensory area, upper limb, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0777 ACHN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.918323 SCC15 CCLE Cell Line Gene CNV Profiles -1.0 -1.41202 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.095 H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAD2L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36532 COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.951223 molecular_function GO Molecular Function Annotations 2015 1.0 null SNU-387 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.678 BRD-K74842791 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80045 GSE176008_0_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null OCIM1 CCLE Cell Line Gene Expression Profiles 1.0 3.17537 HOXB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.3082 GSE193588_1_v_0_pax3_mouse RummaGEO Gene Perturbation Signatures 1.0 null EA-39-YN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.752613 Dorsal claustrum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07671 EP300_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03865 BRD-K29200961 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07237 Lung adenocarcinoma_LUAD_TCGA-35-5375-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HAVCR2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00644459 GSE213588_10_v_2_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K46401069 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15888 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA3_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ribonucleoprotein complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 ACLY Pathway Commons Protein-Protein Interactions 1.0 null GSE152432_6_v_0_zrsr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null MDAMB468 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.09074 BRD-A43076080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.81359 embryo TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CCHCR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01445 CTBP1-25329375-LNCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null TFR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16786 VA-ES-BJ GDSC Cell Line Gene Expression Profiles -1.0 -2.24417 EOL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 9.09613 ZMAT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02351 inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.904768 NDUFS8 Pathway Commons Protein-Protein Interactions 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null chr11_73787049_T_C_b38 GTEx eQTL 2025 1.0 1.6818 GTEX-UPIC-0005-SM-3GACV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22529 H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null fat_e HPA Tissue Sample Gene Expression Profiles -1.0 -0.8784 LSM2 Pathway Commons Protein-Protein Interactions 1.0 null HE-80-BQ08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.18036 CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.22537 GABPA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18667 GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24371 CRCGN008_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -5.8418 POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCAPD3 Pathway Commons Protein-Protein Interactions 1.0 null PTPLAD1 Pathway Commons Protein-Protein Interactions 1.0 null L3MBTL3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00614587 DBH_KO_GSE33906_53_mouse_heart (E10.5) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null DE-34-DT75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.323462 POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SK-N-AS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.05117 skin_6a HPA Tissue Sample Gene Expression Profiles -1.0 -0.955578 GTEX-X4XX-0011-R6B-SM-46MWP GTEx Tissue Sample Gene Expression Profiles 1.0 0.830962 intracellular organelle lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.069761 GTEX-QVUS-2926-SM-3GIJB GTEx Tissue Sample Gene Expression Profiles 1.0 1.00681 POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DD-89-WQ95_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201663 superficial stratum of OB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49988 periaqueductal gray substance, dorsolateral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.38903 Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-W5X1-0006-SM-3GIJZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.950131 CRCGN015_MCF10A.TP53.M_24H:P13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.44885 H3K79me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K23366960 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28904 NFATC1 ENCODE Transcription Factor Targets 1.0 null EEF1E1 Pathway Commons Protein-Protein Interactions 1.0 null DC-47-KV62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.36789 LYVE1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00729193 Intrinsic component of synaptic membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.325 NCI-H2596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.34587 sublayer 6a of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30667 GSE236454,GSE236456_0_v_1_angiotensin ii_mouse RummaGEO Drug Perturbation Signatures -1.0 null S0-EE-XMXE_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.523209 G124 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.830708 ELK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50051 GSE211744_8_v_1_gdf15_mouse RummaGEO Gene Perturbation Signatures -1.0 null WRNIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38895 PMC9013323-13577_2022_685_MOESM7_ESM.docx-6-KDM2A_KDM2A Rummagene Transcription Factor Associations 2026 1.0 null BRD-K72707702 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02831 GTEX-SJXC-0005-SM-2XCE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16679 GTEX-UPK5-1126-SM-3GAEJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.895448 GTEX-XMD1-0011-R10A-SM-4AT4A GTEx Tissue Sample Gene Expression Profiles 1.0 1.73121 COX14 Pathway Commons Protein-Protein Interactions 1.0 null ZNF217 ENCODE Transcription Factor Targets 1.0 null pineal_night BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.49429 A549_Ivosidenib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0168688 ATP5O Pathway Commons Protein-Protein Interactions 1.0 null GSE239541_5_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Cells - Cultured fibroblasts GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.02732 BRD-K51253991 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7597 DEOC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.36842 MRPL12 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-R3RS-1326-SM-48FE7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.30758 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.194 TMEM218 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8716 ALDH1L2 Pathway Commons Protein-Protein Interactions 1.0 null MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HC-74-HM63_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.00602 DMS53 CCLE Cell Line Gene Expression Profiles 1.0 1.89916 urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 mitochondrial ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.962627 LD-39-FL02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.219009 CREB1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null embryoday6.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.03418 CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null PTRH2 Pathway Commons Protein-Protein Interactions 1.0 null 17452630-Table2 GeneSigDB Published Gene Signatures 1.0 null BRD-K16954129 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15722 RAD21_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WB-82-EL69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.358267 MOLT4 BioGPS Cell Line Gene Expression Profiles 1.0 1.42339 BCAS2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30101 BRD-K71671197 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09713 GSE140651,GSE140653_2_v_6_med1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RPS14 Pathway Commons Protein-Protein Interactions 1.0 null FAR1 Pathway Commons Protein-Protein Interactions 1.0 null A204_SOFT_TISSUE CCLE Cell Line Proteomics 1.0 2.06694 PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_unique_ELK4 Rummagene Transcription Factor Associations 2026 1.0 null central nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02757 MARS Pathway Commons Protein-Protein Interactions 1.0 null BRD-K78789413 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22805 PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_10_GATA1 Rummagene Transcription Factor Associations 2026 1.0 null Mitochondrial inner membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 BD-38-QC39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.385914 EE-03-SG02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.269923 ELAVL1 Pathway Commons Protein-Protein Interactions 1.0 null STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null mitochondrial inner membrane GO Cellular Component Annotations 2025 1.0 null HOP-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.01854 mantle zone of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26263 Perturb_1800_KO_Hif1a_SRP198677 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.63635 GSE97278,GSE97280_2_v_1_nsd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null NOP56 Pathway Commons Protein-Protein Interactions 1.0 null GSE202434,GSE202438_6_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null PIK3CA_knockdown_182_GSE46869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.29598 H3K79me2_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null icSARS CoV_48Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.84336 GTEX-X585-0002-SM-46MVA GTEx Tissue Sample Gene Expression Profiles 1.0 1.29871 HS 675.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.72002 GTEX-PX3G-0008-SM-48U2L GTEx Tissue Sample Gene Expression Profiles 1.0 0.928448 ZZZ3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TOM complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.786 BRD-K16598630 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1844 RPUSD3 Pathway Commons Protein-Protein Interactions 1.0 null organelle LOCATE Curated Protein Localization Annotations 1.0 null amygdaloid complex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.85866 globus pallidus, external segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.92059 SARS-BatSRBD_12Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.09348 Cells - EBV-transformed lymphocytes GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.00244 SU-DHL-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.37574 BRD-K53639581 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47755 GSE192689_0_v_1_ricin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OHPK-1826-SM-2YUMR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.93786 GSE153871_5_v_3_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null MRPS34 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K33956641 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21555 superficial stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.52611 X Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.882384 adrenocortical carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.42981 GSE199255,GSE199356_6_v_2_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary motor-sensory cortex (samples)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.03668 GSE119978,GSE180930_0_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null EZH2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL32 Pathway Commons Protein-Protein Interactions 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19W-06A-41R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA46 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.60415 BA-59-EN38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.390112 H3K4me1_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE95077_5_v_3_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null GM2313 BioGPS Cell Line Gene Expression Profiles -1.0 -1.19508 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.9148 A549_Celecoxib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0114107 AARS2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K58596567 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09336 DA-33-BM26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.259687 SOX2-27498859-CHIP-SEQ-STOMACH-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SP1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_PHA-680632_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0172577 r10 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09362 U251MGDM DepMap CRISPR Gene Dependency 1.0 2.03756 19351829-SuppTableA GeneSigDB Published Gene Signatures 1.0 null H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TRIM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37397 POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular non-membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.76388 tretinoin_homo sapiens_gpl6244_gds4180 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-N7MS-0011-R5a-SM-2HMK8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.974955 FOSL2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRPL18 Pathway Commons Protein-Protein Interactions 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.6011 Mitochondrial ribosome COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.987385 GSE109285_3_v_2_glucagon_mouse RummaGEO Drug Perturbation Signatures -1.0 null TestisGermCell BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.64764 posterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.986795 LRRTM4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00658122 PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR Rummagene Transcription Factor Associations 2026 1.0 null rosiglitazone_mus musculus_gpl8321_gds4021 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K9me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR3A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCC142 DepMap CRISPR Gene Dependency 1.0 2.00008 GSE228413_0_v_1_mavs_mouse RummaGEO Gene Perturbation Signatures -1.0 null MRPL51 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null PARP1 Pathway Commons Protein-Protein Interactions 1.0 null dactinomycin_mus musculus_gpl1261_wild type_gds2456 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GATA3_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE160817_5_v_6_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null cytoplasmic part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 DDX56 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE116810_5_v_3_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.867107 GTEX-WZTO-0006-SM-3NM9T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25294 MBD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL78 CCLE Cell Line Gene CNV Profiles 1.0 1.62412 MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBPJ JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7527 DF-00-BX35_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.49747 IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null ZBTB12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1557 POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K36289678 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23154 TEX41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02313 K562_WHI-P154_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0181641 POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null APOBEC3G LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00636206 IGF1_OE_GDS3484_538_human_MCF-7 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-N7MT-0011-R10A-SM-2I3E1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.948065 thyroid_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.81398 BRD-K88447092 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06824 hsa-miR-922 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 AA-46-GL76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.303275 PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null KD DepMap CRISPR Gene Dependency 1.0 2.12729 TAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null frontal cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15024 POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4LF-0006-SM-3NMCO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54969 HCC630 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.840971 PMC5578490-pgen.1006879.s017.xlsx-Top_ETV1_downregulated_genes-Gene_Symbol_ETV1 Rummagene Transcription Factor Associations 2026 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-7910-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adrenocortical carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.108 BRD-K45472595 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.60991 Adrenocortical carcinoma_ACC_TCGA-OR-A5K2-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.4488 BRD-K76450447 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5665 Main olfactory bulb, outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09944 H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN008_HEPG2_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5178 BRD-K19040732 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41729 organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.046058 NSG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46828 Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47509 GTEX-VJYA-0326-SM-3GAEX GTEx Tissue Sample Gene Expression Profiles 1.0 1.12635 RAD21_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-REY6-1426-SM-48FDK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.84376 r7 part of cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75236 CRCGN009_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.73195 PCBP2 Pathway Commons Protein-Protein Interactions 1.0 null Intramolecular phosphotransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.818 GTEX-T6MN-0011-R11A-SM-32QOX GTEx Tissue Sample Gene Expression Profiles 1.0 0.866601 GTEX-TSE9-0426-SM-3DB81 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1732 cell part LOCATE Predicted Protein Localization Annotations 1.0 null Perturb_8708_KD_Irf2_SRP193480 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.24183 Adenocarcinoma CTD Gene-Disease Associations 1.0 1.02336 Perturb_1126_KO_Myc_SRP168941 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.5827 PMC9336541-Table_3.XLSX-C-vs-H6-L_filter_annot-Unnamed_18_HMX1 Rummagene Transcription Factor Associations 2026 1.0 null pioglitazone_homo sapiens_gpl570_gds4132 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE186287_2_v_3_ufm1_human RummaGEO Gene Perturbation Signatures 1.0 null TAF7_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K95153342 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.05428 QE-79-XO29_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.338167 GTEX-P4QR-0426-SM-2S1NV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.946148 CRCGN016_MCF10A.TP53.M_24H:B18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.01658 H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mitochondrial translation GO Biological Process Annotations 2023 1.0 null dexamethasone_mus musculus_gpl6105_gse44208 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CD3EAP Pathway Commons Protein-Protein Interactions 1.0 null BRD-K58300049 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15579 496100626_FWM_no dementia_TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.8168 Adrenocortical carcinoma_ACC_TCGA-OR-A5JX-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3ES-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.968148 organelle part GO Cellular Component Annotations 2015 1.0 null PRPF19 Pathway Commons Protein-Protein Interactions 1.0 null PMC12171002-jcav16p2578s1.pdf-90-ARID2_ARID2 Rummagene Transcription Factor Associations 2026 1.0 null G112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05628 CB-99-OG76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.212723 CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.10716 dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.85277 MS4A5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00608994 anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.920377 RBM19 Pathway Commons Protein-Protein Interactions 1.0 null GSE147240_3_v_4_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null APECED - Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy_Thymic epithelial cell_GSE85 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.27 GSE158834_2_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG Rummagene Transcription Factor Associations 2026 1.0 null HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.61144 E2A-27217539-CHIP-SEQ-RAMOS-CELL-LINE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MRPL2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-S4Q7-0006-SM-3K2AT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40573 Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T3-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BB-79-AG41_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.348447 BRD-K54036439 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11907 sirolimus_mus musculus_gpl1261_gse5332 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null QA-50-YO37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.15325 H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTF2B ENCODE Transcription Factor Targets 1.0 null MD-91-JM80_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237884 K562_BRD4770_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0170193 RNF112 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00607551 RAJI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.63015 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A262-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T5JC-0011-R2A-SM-32PLZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.945798 GTEX-S32W-2326-SM-2XCAW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08843 BRD-K48670593 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37121 MRPL37 Pathway Commons Protein-Protein Interactions 1.0 null PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-66-QO48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.206031 DC-78-CM38_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.305507 496100327_PCx_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.18484 CE-18-AP15_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.494417 H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ANXA2 Pathway Commons Protein-Protein Interactions 1.0 null NCI-H522 GDSC Cell Line Gene Expression Profiles -1.0 -1.86882 CEBPD JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.4946 Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null globus pallidus, internal segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1357 DDX5 Pathway Commons Protein-Protein Interactions 1.0 null Streptococcal tonsillitis_Tonsillar Lymphoid Tissue_GSE11494 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.47545 GSE227592_8_v_1_adar_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43636 testis_7a HPA Tissue Sample Gene Expression Profiles -1.0 -2.05263 VD-88-MW70_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.30755 CAPRIN1 Pathway Commons Protein-Protein Interactions 1.0 null HSPA13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07565 GTEX-R55C-1626-SM-48FEG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.833525 GTEX-WVLH-2926-SM-3MJG5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25131 NR3C1-23031785-PC12-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE192870_2_v_0_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null Primary somatosensory area, mouth, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.28613 TAF7_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null AA-86-YY62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.308775 mitochondrial part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 BRD-K41814083 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.576 MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K95588139 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11096 urinarybladder_5c HPA Tissue Sample Gene Expression Profiles 1.0 0.989945 K562_Ki16425_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.016852 TA-19-YA45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.210177 GTEX-OIZI-1326-SM-3NB1B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.914978 POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-4_names_TP53 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PVOW-0011-R1A-SM-32PL6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.824215 SAP30 ENCODE Transcription Factor Targets 1.0 null PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Duodenum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.248 H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-O5YT-0007-SM-32PK7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3141 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mitochondrial translation initiation Reactome Pathways 2014 1.0 null GBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.5846 posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.50965 striatum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.42476 BRD-K31197843 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.85558 MRPL54 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN008_HEPG2_24H:O13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.62195 GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -2.25517 MCF7_Avagacestat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0144378 FOXM1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U4B1-1126-SM-4DXV3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.832081 Main olfactory bulb, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62407 GTEX-V955-0426-SM-3GAEL GTEx Tissue Sample Gene Expression Profiles 1.0 1.16614 GSE193402_0_v_2_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lymphnode_5c HPA Tissue Sample Gene Expression Profiles 1.0 1.09658 Perturb_8398_KD_Safb_SRP180874 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.17957 HCC78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.865051 HE-80-BQ08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.54578 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null adipose tissue GTEx Tissue Gene Expression Profiles -1.0 -1.15939 GSE160817_5_v_1_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null GLTSCR2 Pathway Commons Protein-Protein Interactions 1.0 null ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABP-19822575-HEPG2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K49029187 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3811 MRPL21 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K75672292 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13174 Primary motor area, Layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49462 GNL3 Pathway Commons Protein-Protein Interactions 1.0 null DUX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.7446 GSE158834_7_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YR-01A-12R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE211744_2_v_0_gdf15_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K59041191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59732 FUS Pathway Commons Protein-Protein Interactions 1.0 null NCR1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00521408 CRCGN008_HEPG2_24H:L15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1818 H3K4me1_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM10847_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K67638302 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.79288 Acquired Immunodeficiency Syndrome HuGE Navigator Gene-Phenotype Associations 1.0 null HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null gracile nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.865794 HT-144 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00483 BRD-K61087440 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13236 GTEX-XBED-0003-SM-47JWP GTEx Tissue Sample Gene Expression Profiles 1.0 1.61391 Perturb_3093_KO_H1foo_ERP017365 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.76546 NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.862691 EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BF-94-CQ58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.298164 TAL1 ENCODE Transcription Factor Targets 1.0 null emboliform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.64968 Preputial gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.701 STAT5A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 9969_ZBTB11_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.577509 CRCGN015_MCF10A.TP53.M_24H:M18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.26015 MAX_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70001 BRD4_knockdown_223_GSE50865 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.08709 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NF-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE213588_10_v_6_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.937854 BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 fetus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Primary somatosensory area, lower limb, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.87474 SK-MEL-28 GDSC Cell Line Gene Expression Profiles -1.0 -2.18601 Cardiovascular Diseases CTD Gene-Disease Associations 1.0 1.2208 creatinine GAD Gene-Disease Associations 1.0 null GSE108614,GSE108615_0_v_2_setd1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE153354_0_v_1_tcf19_human RummaGEO Gene Perturbation Signatures 1.0 null KA-75-LP02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.342596 DF-00-BU08_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.702601 MBL2 Pathway Commons Protein-Protein Interactions 1.0 null PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2 Rummagene Transcription Factor Associations 2026 1.0 null 9837_WDR70_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.632526 BRD-K83919473 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02187 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.043097 Perturb_5264_OE_Dcaf11_SRP328699 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.91693 ARGFX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.9461 GTEX-SNMC-0926-SM-4DM5U GTEx Tissue Sample Gene Expression Profiles 1.0 0.84043 GATA3_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE206270_2_v_0_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null PHF8 ENCODE Transcription Factor Targets 1.0 null HCC366 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30931 AB-97-BI36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20186 HIV - Human immunodeficiency virus infection_T lymphocyte_GSE6740 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.75491 JUN-26020271-SMOOTH-MUSCLE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BB-74-RX30_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.518179 dorsolateral part of Med Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07715 IL1RAPL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00730318 IGF2BP2 Pathway Commons Protein-Protein Interactions 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3HZ-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null piriform cortex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.866419 KARPAS299 CCLE Cell Line Gene CNV Profiles -1.0 -1.79338 TAF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 2114_DDX27_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.516994 hnf4a_16714383_e18dot5_liver_lof_mouse_gpl1261_gds1916 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.035543 MYC-18940864-HL60-human ChEA Transcription Factor Binding Site Profiles 1.0 null ME-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.86255 G130 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.6866 MAP3K7_knockdown_37_GDS5023 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -3.13327 EW-1 GDSC Cell Line Gene Expression Profiles 1.0 1.52307 GSE153341_2_v_3_atf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null KRAS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.005793 MRPL1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-RU72-1026-SM-46MUG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.981823 XRN2 Pathway Commons Protein-Protein Interactions 1.0 null MAX_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBX3 ENCODE Transcription Factor Targets 1.0 null H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.98585 YARS2 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K30615964 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04465 cerebellar cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0206 NRF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLC25A12 Pathway Commons Protein-Protein Interactions 1.0 null PRRC2C Pathway Commons Protein-Protein Interactions 1.0 null GSE95688_7_v_5_glutathione_mouse RummaGEO Drug Perturbation Signatures -1.0 null NS-0 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.94 MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null AB-71-CI37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.708157 HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE155162,GSE155169_1_v_3_buparlisib_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_13456_OE_Smn1_SRP366489 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.38224 eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ME1 CCLE Cell Line Gene CNV Profiles 1.0 1.42178 GTEX-WHSE-0006-SM-3NMBW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27799 POLR2E Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XLM4-0011-R8A-SM-4AT44 GTEx Tissue Sample Gene Expression Profiles 1.0 2.84727 AB-84-PK04_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.292904 SCC-25 COSMIC Cell Line Gene CNV Profiles 1.0 2.49065 EE-03-SG02_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.246247 HDDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7225 POMGNT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02163 MAFK_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR3C1 ENCODE Transcription Factor Targets 1.0 null superficial stratum of r1BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52737 GTEX-WHSE-1126-SM-3NMBU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.908948 DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.54417 JARID1A-20064375-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Primary visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19126 YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11C-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELK1::SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.5106 GSE149264,GSE149267_4_v_5_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.61714 TMEM214 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K37161540 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02062 LRRC59 Pathway Commons Protein-Protein Interactions 1.0 null POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NY GDSC Cell Line Gene Expression Profiles -1.0 -1.91525 ASPH Pathway Commons Protein-Protein Interactions 1.0 null