association	dataset	threshold value	standardized value
BRD-K79106177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41252
CRCGN015_MCF10A.TP53.M_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0083
Plastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.77
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.43667
Sternum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.13
CRCGN009_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.56219
L3MBTL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49715
Cholera	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.174
BRD-K61491580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3439
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K18197334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80575
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.96246
CRCGN017_MCF10A.WT.HP_24H:P18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3762
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_1_ZZZ3_ChIP-seq_peaks-Nearest_TSS_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K29028138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79725
Seed coat	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.949
BRD-K82105167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58943
GSE190384,GSE190386_2_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mouth	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
7438_RPL14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.557611
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_1_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.50119
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8732
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.610471
PRDX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0077444
Urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.206
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.409776
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.502
A549_BRD4770_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140033
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7319
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.75765
GSE109530,GSE109531_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.52965
CRCGN011_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8249
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.3915
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0818
JA-23-QE71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.283722
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130676_0_v_2_suds3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SPOTS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.321
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7d4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.899
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.61746
Silique	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.12
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.15923
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXC8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.5833
GSE122215,GSE122217_5_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
carboplatin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03536
GSE203158_1_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-43-ZC52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255846
BRD-K30937829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0188
p92	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.722
dg2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.128
TGM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00443601
Inflorescence	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.082
GSE190384,GSE190386_3_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
Conjunctiva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.989
vp8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	3.112
Vacuolar transporter chaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.59
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.53
vh2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.857
GSE186005_1_v_2_klf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07173
BRD-K73027631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08946
Germ plasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.646
POLR3H	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00565629
Mitochondrial large ribosomal subunit - 2	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
Disc	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.904
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Extravillous trophoblast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.912
GSE119345_2_v_4_bexarotene_human	RummaGEO Drug Perturbation Signatures	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.55996
2132_DDX56_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.561391
SKA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37848
Malaria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.245
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.33104
Bolting stage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.714
PMC11615365-41467_2024_54246_MOESM6_ESM.xlsx-KK47-Numb-KD_vs_Ctr-KD-ensemblGeneId_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ipi1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.063
Pole plasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.644
496100410_TCx_possible Alzheimer's disease_TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.26701
Mitochondrial inner membrane peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.064
2124_DDX47_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.554134
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.08899
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.59736
AE-85-KE62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218044
PMC3669416-pone.0064838.s005.xls-mTP53-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gynoecium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.449
Floral primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.701
CRCGN017_MCF10A.TP53.M_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.11937
BRD-K59544784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22713
GSE113329,GSE113335_3_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
9841_WDR75_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.503657
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.7533
Plantlet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.70932
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.669
Retrotransposon nucleocapsid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.282
CRCGN012_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.773
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
LHX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.286
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.433
ls1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.818
BRD-K25645002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5227
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Leigh disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.277
Lower urinary tract calculus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5724
Nucleus reuniens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.511
UM-SCC-22A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.639
CRCGN016_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.50992
CRCGN017_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4528
BRD-K04378630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99752
DNAJC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09166
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.2796
CRCGN011_HEPG2_24H:C14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8036
BA-84-TD72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238744
BRD-K47254434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15681
GSE221004_1_v_2_prdm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.504737
GSE229671,GSE229673_2_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Radicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.87
IPO13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21491
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE86021_1_v_2_crenolanib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.66678
GSE77108_8_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.7803
BRD-K25942808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51857
Cell plate	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.654
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K74626943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94621
BRD-K80736363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11746
BRD-K72866723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19059
Transport vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.92
carbamoyl-phosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.74
GSE111247_11_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.18545
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
BRD-K14781269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41941
BRD-K81821040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5406
CRCGN011_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.86575
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.263
BRD-K39863565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01752
ABCF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02665
clathrin-coated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.08
AE-51-ZO26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244451
BRD-K51933590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08683
Guanfacine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.52
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.56785
Cytosolic small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.847
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190384,GSE190386_6_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ribonucleoprotein complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
i-AAA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.75
BRD-K00717406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.298
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K46562329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32331
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.26196
NDUFC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00488146
rescue of stalled ribosome	GO Biological Process Annotations 2025	1.0	null
CALCOCO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11242
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.44
BRD-K33454318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12738
K-562 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.23
KLF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41124
PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
PAX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5349
LMF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16757
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1925
Plastid inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.016
GSE211931_2_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Autoimmune disease of the nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.091
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.52543
BRD-K58194737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17198
BRD-K58277621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39755
AC-30-XU83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300639
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.49502
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.8672
HOXD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11301
Gastroenteritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	3.069
Primary biliary cholangitis 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
496100326_TCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07781
Artery - Aorta	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.719361
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
4208_ISG20L2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.526329
Bpe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.557
BRD-K05225561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09749
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.297
Presynaptic active zone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.358
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
naltriben-mesylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08203
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:G09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03113
Decidua	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.442
CRCGN013_HEPG2_24H:G17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30066
GSE146982_7_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186440,GSE186443_2_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mitochondrial ribosome	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.62419
GSE147056_4_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196540,GSE196542_2_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.436
Primary root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.951
PD-94-WO47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266021
BRD-K94921631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02639
Distal arthrogryposis type 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.733
PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Supplementary_Table_9A_The_effects_of_whole_blood_transcripts_on_COVID-19_severity_with_suggestive_Mendelian_randomization_evidence_P_0_05_using_Genomicc_data_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE198971_0_v_2_ncor2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE125403_7_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.49337
BRD-K36170990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39887
VRK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68677
AE-88-WQ63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256633
Pod	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.585
BRD-K62942008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04918
TMEM42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16155
Plant reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.715
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitochondrial ribonuclease P complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.883
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
Coleoptile	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.742
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.73703
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5033
Nr1h2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.5387
Panicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.171
NRP-154 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.948
CRCGN011_HEPG2_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38575
BRD-K87479423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19729
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.07661
2105_DDX18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.558994
Tergal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.401
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.35791
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mouth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
CRCGN017_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.84095
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42531
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7025
CD276	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19256
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.5119
NF-21-HQ00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285421
CRCGN015_MCF10A_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6304
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.97985
WM88_SKIN	CCLE Cell Line Proteomics	1.0	4.31765
Small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.241
HOXB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.746
PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Amp_AA-TCGA-Unnamed_20_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Tooth enamel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.784
6963_PWP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.584652
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3419980-leu201249x4.xls-H3K9Ac-RUNX1ETO_peaks_2fold-All_gene_regions_overlapping_with_RUNX1-ETO_peaks_changing_histone_acetylation_more_than_2-fold_after_knock-down_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K23670243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68308
BRD-K95160020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05848
CRCGN011_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24415
BRD-A80010944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19294
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.42084
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.44951
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.751
Anococcygeus muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.541
PANK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00501086
CRCGN008_HEPG2_24H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6377
105_ACTG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.510392
HA-22-CY42_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26453
EIF3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12489
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25815
BRD-K30661365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28216
GSE149124,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K26866198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27547
Chloroplast stroma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.107
7482_RPLP0_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.538714
NFE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03109
Labial palp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.73
Bipolar disorder	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.539794
translation release factor activity	GO Molecular Function Annotations 2023	1.0	null
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
10478_ZNF585A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.799243
CRCGN015_MCF10A_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6377
Medial entorhinal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.794
GATA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50374
EXOC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0767
Leukocyte disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
Chromosomal duplication syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.799
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
9971_ZBTB14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.69383
Intestinal juice	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.751
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.11876
ds19	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.982
PMC5651844-41467_2017_1173_MOESM7_ESM.xlsx-ZZZ3_ChIP-seq_peaks-Unnamed_7_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
AF-99-HA02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242652
Decidua parietalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.801
Ribonuclease P complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.036
BRD-K68328788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24783
Storage root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.711
CRCGN015_MCF10A.WT.HP_24H:G18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.29447
NF-21-HQ00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08751
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.68309
NMRK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00529856
CRCGN017_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.8897
CRCGN016_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.51246
BRD-K02087489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11232
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.6565
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
7458_RPL30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.626993
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8153
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.80743
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.19381
FA-88-II68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.367181
PXMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30627
APIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31393
BRD-K19969618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28658
GSE210655_1_v_7_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K50157358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77065
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K83487481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0147
CE-69-HJ13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.13802
GATA3-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
MYLK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00514043
BRD-K66985689	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13681
Protophloem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.007
AA-43-BW50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.313711
Final leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.182
6283_PHF19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.516986
CRCGN017_MCF10A.TP53.M_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.73529
GTF2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56098
BRD-K49656278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13498
GCNT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6361
BRD-K23435841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99547
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.40694
BRD-K49721311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37939
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.522233
ABCC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00319027
BRD-K84178323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14514
Large ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Organellar large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.377
7467_RPL37A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.519693
PRMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13046
AKAP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34066
Lateral meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.722
Plastid stroma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.167
COPS9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78105
mitochondrial membrane	GO Cellular Component Annotations 2023	1.0	null
CRCGN012_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0059
CRCGN017_MCF10A.TP53.M_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56268
RIPOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07547
GJB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00503682
BRD-K56057104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04364
BRD-K75243062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57184
GSE193258,GSE193259_5_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2567_EIF4E_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.583201
BRD-K69349031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41007
Hemolymph	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.98
SLC39A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37424
Floral meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.717
BRD-K94744294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53527
GSE181517_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Attention deficit hyperactivity disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
GTEx AdiposeTissue 20-29 vs 30-39	GTEx Tissue-Specific Aging Signatures	-1.0	-5.62335
7474_RPL4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.674956
CRCGN016_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.58597
Mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Visceral hump	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.02678
CRCGN015_MCF10A.TP53.M_24H:C17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2629
Helab	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.602
7576_RSL1D1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.666863
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5675
ATR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.005826
SLC12A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00496034
BRD-K90901488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14511
Type IV pilus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.873
CRCGN016_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.07217
BRD-K27384243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04231
SUN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1697
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.401601
Rectus femoris	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.656
AP-2 adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.695
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.38
BRD-K67902591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25897
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Shoot tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.138
BRD-K54751293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26567
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.11399
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.510158
Mitochondrial inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CRCGN014_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0755
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Glucosidase II complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.431
plant-type cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.352
BRD-K35119180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17124
BB-20-UU03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.42909
CRCGN015_MCF10A.TP53.M_24H:G22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.6262
Nuclear lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K72317601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35078
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3208
GSE182179_0_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29034
CRCGN010_HEPG2_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15291
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
Floret	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.353
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
7480_RPL8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.56799
B cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.535
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
PMC8384902-mmc5.xlsx-H128_ASCL1_ChIP-Symbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K56739005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33435
GA-28-SS67_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.08749
Plastid ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.29
GSE201239_3_v_2_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K24669989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78638
CRCGN011_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1706
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.224
CRCGN014_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.31055
Androgen Independent Prostate Cancer	DisGeNET Gene-Disease Associations	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
BRD-K67478255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99363
RRP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.5614
GSE188570,GSE188571_3_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7461_RPL34_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.565383
BRD-K27911943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71251
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.244
FD-59-TC81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.350015
Transcription export complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.08
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23335
BRD-K35347834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34541
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.73887
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.18745
1792_COQ3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.704678
GSE111247_11_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.64299
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.37375
BRD-K35646839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01055
GSE216043_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.51478
IL1RAPL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00901969
Villous cytotrophoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.83
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20685
CE-15-YU05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.525783
BRD-K20451745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69083
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.412
GSE95077_5_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
Stem cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.574
CRCGN008_HEPG2_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65545
BE-42-IC00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.439602
HOXD8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6716
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.911
AA-48-XT80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249388
Multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
fs6	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.827
CRCGN017_MCF10A.WT.HP_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4237
Spinal column	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.185
7499_RPS11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.568538
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.04305
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01805
BRD-K30964167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25741
QE-00-EB96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346013
Exoskeleton	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.01
5089_NIFK_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.550285
CRCGN016_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.57261
BRD-K45398957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01004
GSE217105_0_v_1_gemcitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PIP5KL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00636226
CRCGN011_HEPG2_24H:H14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0193
GSE119345_0_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K01577807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35481
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.19931
PMC12405659-CTM2-15-e70437-s001.xlsx-Supplementary_Table_5-BioGrid-interaction_protein_with_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GA-77-MH38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255803
PPP3CB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61564
Combined oxidative phosphorylation deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
CRCGN016_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29441
BRD-K24965236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13501
Husk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.753
LBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3289
BRD-K30269093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68574
GSE183271_2_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
carboxylic ester hydrolase activity	GO Molecular Function Annotations 2023	1.0	null
S-layer	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.705
CRCGN017_MCF10A.WT.HP_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4934
Sensillum trichodeum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.424
BRD-K12801140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88463
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.74265
BRD-K80766355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06692
BRD-K83898111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49223
CRCGN010_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1512
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.501808
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Scutellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.918
9687_UTP6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.654683
BRD-K37850190	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43894
BRD-K13044705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.54704
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.3474
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.593
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.21037
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.23338
Mitochondrial ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.591
BRD-K25103635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08376
Developmental and epileptic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
Clathrin coat of coated pit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.694
CRCGN015_MCF10A.WT.HP_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.76268
KA-29-AB08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202133
AP-type membrane coat adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.083
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.43261
BRD-K15019832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30768
9909_XRCC6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.657848
translation release factor activity, codon nonspecific	GO Molecular Function Annotations 2025	1.0	null
GSE231648_0_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K35587518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27411
BRD-K41412255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09467
MSX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13395
DC-84-GJ21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.480882
6043_PAK1IP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.641637
Sporangiophore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.133
CRCGN008_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0467
CRCGN013_HEPG2_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5781
Hip joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.778
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8619
Petiole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.141
Synaptic vesicle protein transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.626
8660_TAF1D_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.538858
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208908
BRD-K67638302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3743
BRD-K08835142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46875
8252_SNX29_ENST00000306030.3,ENST00000323433.4	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.506361
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.7604
Bundle sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.73
CRCGN014_HEPG2_3H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1894
bc96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.664
BRD-K67979704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23374
yeast-form cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.006
C1QL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17504
Stomach Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Metabolism of proteins	Reactome Pathways 2024	1.0	null
Plastid nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.622
DPEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04777
translational elongation	GO Biological Process Annotations 2025	1.0	null
CRCGN015_MCF10A_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.25244
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.512
Spike	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.895
pi1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.388
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.433125
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K91225366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0142
Leukemia	DisGeNET Gene-Disease Associations	1.0	null
NRP-152 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.821
phi1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.442
COASY	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00378957
Bone marrow stromal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.629
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.017
BRD-K94082609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70953
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.518
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH358_LUNG	CCLE Cell Line Proteomics	1.0	2.7281
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Leaf tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.722
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.352
PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
IgM B cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.686
Rad51B-Rad51C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.609
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20707
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.706317
EMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8424
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
Endopeptidase Clp complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.722
toxin-antitoxin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.817
CRCGN011_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0225
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.3893
Lignifying cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.672
7512_RPS23_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.647161
BRD-K35193502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67127
7522_RPS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.507124
BRD-K32451879	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84901
ZA-63-AC60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205867
CRCGN017_MCF10A.TP53.M_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6007
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.364842
EYA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04154
IgG immunoglobulin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.651
LN229_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	5.72328
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.49968
BRD-K52383401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.419
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.771
cm86	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.921
CRCGN010_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5045
CRCGN015_HEPG2_48H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23936
Spongiome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.936
GSE84922,GSE84924_0_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mitochondrial inner membrane	GO Cellular Component Annotations 2025	1.0	null
Chromaffin granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.647
FAM111A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03619
RTL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03949
GSE193258,GSE193259_5_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Anal fin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.546
BRD-K34798837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15426
Golgi-associated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.262
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.30266
BRD-K04771555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49707
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.695091
496100456_TCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.32983
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.09789
ERBB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00362052
UBE2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04851
BRD-K89660028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50383
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
decreased bone mineral density	IMPC Knockout Mouse Phenotypes	1.0	null
GSE240386,GSE242143_1_v_4_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202284,GSE202289_5_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0316
BRD-K35421408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06507
mitochondrial matrix	GO Cellular Component Annotations 2025	1.0	null
CRCGN012_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47043
BRD-K93148720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1365
BRD-K91399333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8424
GTPBP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0059976
GSE210655_1_v_6_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H-NS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.62
CRCGN015_HEPG2_48H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33501
COPI-coated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.129
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.494
BRD-K81982648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23891
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PSKH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00456169
ME-11-OJ38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20028
BRD-K97869597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09919
PMC13137955-ijbsv22p4243s2.xlsx-Sheet1-hTFtarget_E2F3_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.879
AC-38-WM38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203366
BRD-K30467307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05312
GSE223893_2_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147662_3_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.503
BRD-K32593492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07664
GSE206784_3_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BF-22-EP86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237436
8517_STK24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.767884
CRCGN016_MCF10A.WT.HP_24H:A15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.92118
RPL7L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57641
ABHD15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31721
9396_TTF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.508121
HS3ST3B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15114
Subapical complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.767
Bhlha15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.9929
PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_right-x_TFEB_KOcon_VS_WTcon_UP_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K44521151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03124
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC2A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31531
NACAD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13295
BRD-K12460934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08127
Dental caries	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
Skeletal muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.186
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.659
PC-18-VX23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.543833
BRD-K42809349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09568
2567_EIF4E_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.512473
Contractile vacuole complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.227
Intestinal obstruction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.53
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3553
IgD B cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.507
Lower epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.898
PMC12513837-41588_2025_2336_MOESM4_ESM.xlsx-Supplementary_Table_1-Supplementary_Table_1_List_of_AR-only_and_p300_AR-shared_enhancer_regulated_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K11054031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59484
PMC8283158-mmc2.xlsx-TCF4_ChIP-symbol_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
Occipital pole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.579
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.951
Palmitoyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.271
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0897
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
HNRNPU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92107
CRCGN009_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31634
FMO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00567276
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Fatty acid beta-oxidation multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.542
CRCGN011_HEPG2_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1714
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.896
Golgi stack	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.16
RPS6KB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0067352
BRD-K24529791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43243
Prostate Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EB-67-WB79_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246739
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8966
BRD-A44990218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01252
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.721
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.785067
ESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0462
CRCGN016_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.60631
CRCGN015_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.20426
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.365
sse5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.726
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6984
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.54215
Bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.659
BRD-K18346873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17772
PMC4634137-ncomms9549-s7.xlsx-ZF_Hair_cell_data-Unnamed_1_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.64715
CRCGN008_HEPG2_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3234
gb95	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.499
Sotos syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.31
CRCGN011_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1869
CRCGN015_MCF10A.WT.HP_24H:C04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.97849
Systemic lupus erythematosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
BRD-K40804250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60884
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.2296
Rad51C-XRCC3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.686
SIGLEC14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0062264
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3989
CRCGN017_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.44065
Upper epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.732
PTPN23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08333
BRD-K75451592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22147
Hinge joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.174
CRCGN017_MCF10A.WT.HP_24H:A11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20665
7431_RPL10A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.695468
CRCGN017_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12266
KATNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10191
GSE186287_1_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213632_1_v_5_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.729
TRIM29	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00602197
GSE239578_0_v_6_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Flower bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.041
CB-87-RB49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208899
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.97765
BRD-K94516254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66959
BRD-K96737756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5678
BRD-K82198647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85314
BRD-K44260904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33738
Golgi trans cisterna	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.665
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
1200_KNL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.662927
GSE154767_1_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.591
PMC12260418-pnas.2425984122.sd01.xlsx-TEAD4_6fraction_test_result-Unnamed_3_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.7508
GSE245270_2_v_5_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.61889
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.85508
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.637489
BRD-K65054381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00485
GSE147366_1_v_4_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Primary leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.016
IFIT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00741298
CE-15-YU05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.620351
CDC23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33626
GSE158834_0_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SHP77_LUNG	CCLE Cell Line Proteomics	1.0	2.3738
A549_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122036
GSE252857_1_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Leaf sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.129
Organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Pupa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.739
Tassel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.798
6032_PAF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.51155
CRCGN015_MCF10A.WT.HP_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.72098
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4482
Mitochondrial complex IV deficiency nuclear type 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
Diffuse large B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.231
Internode	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.154
BRD-K38617061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3481
BRD-K34929471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00696
psi2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.129
MCHR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00568132
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TEAD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.129
CRCGN015_MCF10A.TP53.M_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4457
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim22_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8325
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.5278
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Parasitic infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
CRCGN014_HEPG2_3H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.90625
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.58432
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.6655
BRD-K60578515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45336
Orthogonal array	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.808
BRD-K13922961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07963
ASTRA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.76
CRCGN015_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3452
ETV2::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9227
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3061
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.67267
PMC3290552-pone.0032232.s006.xls-MUC4-KD_vs_Mock-Unnamed_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K83125173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16587
BRD-K97929312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04972
6605_PPAN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.575806
ZNF385C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10306
Asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
light-harvesting complex, core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.19
BD-96-HO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334881
OB-06-WW76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233198
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.33635
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7107
BRD-K87472370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06465
GSE125403_7_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.48711
CRCGN008_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03145
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.30981
Occipital lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.194
trans-Golgi network transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.981
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.165
CRCGN009_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65391
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.905991
BRD-K71604153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05263
Tarsal bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.516
pre-B cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.101
496100337_HIP_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13359
AB-80-CK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.626216
BRD-K88395026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25847
CRCGN014_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.18533
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
BRD-K62511698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12175
ATP-binding cassette (ABC) transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.683
MFNG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12386
BRD-K93990956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03587
BRD-K50094173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09422
Hamstring muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.294
mitochondrial translation	GO Biological Process Annotations 2023	1.0	null
Limbic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.297
BRD-K89638177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39009
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.85023
HE-22-JR80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227995
TNFRSF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06495
BRD-K28216304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79868
MRPL58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16743
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1514
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.394
Pleopod	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.769
BRD-A24524033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30719
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224558
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9643
BRD-K24108193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18059
GSE210476_2_v_1_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K42575648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22058
BRD-K69718434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28762
BRD-K38966099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40274
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Nucleoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.512419
CRCGN016_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.979
VAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.6268
KA-71-CQ35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225209
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.6671
BRD-K19962165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37542
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Leaf epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.355
Ankle joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.122
CX-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.665
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Clathrin vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.088
AHCY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05837
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.631
PMC5691083-41467_2017_859_MOESM6_ESM.xlsx-FDR_0_1_RELB_RNAi-Unnamed_1_RELB	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.05335
CRCGN015_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3713
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09223
GA-94-MC54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215517
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.74332
AP-4 adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.655
SLC2A12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00684
BRD-K91271834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11344
CRCGN008_HEPG2_24H:O23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6339
GSE114258_1_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0355
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.536
Sinus node	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.78
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.351
DCANP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66822
GSE158834_0_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE140092_0_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Borderline personality disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.094
Ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
DNA recombinase mediator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.012
Tic complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.021
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1006
BRD-K16109630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28225
substance-induced psychosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.191
PLS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0057751
7561_RRP12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.677083
CRCGN015_HEPG2_48H:E18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.18365
BRD-K64215435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69124
Stigma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.116
BRD-K47511177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02283
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_Jurkat_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.572
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28803
BRD-K29760532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21148
XBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00409055
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.08193
HEL-92.1.7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.09
Apoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.05
CRCGN014_HEPG2_3H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24673
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280264
BRD-K87794979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08512
SLX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1503
TSPAN9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00536205
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.579
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.99365
Sensillum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.238
CRCGN013_HEPG2_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17827
BRD-K51411441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47256
Major depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.272
5735_NOL6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.582485
BRD-K54262203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27241
CRCGN014_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16256
CRCGN016_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46997
8232_SNRPF_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.50361
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.32855
BDH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00389217
GSE231648_4_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mitochondrial gene expression	GO Biological Process Annotations 2023	1.0	null
Influenza	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.666
Pith	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.525
Lymph	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN008_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6659
CD226	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00508807
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.42535
abnormal embryo size	IMPC Knockout Mouse Phenotypes	1.0	null
Coronavirus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.663
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.84741
Rhox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.8797
7475_RPL5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.613365
BRD-K78931693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02318
GSE113106_2_v_1_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.09358
BRD-K71221636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36588
GSE184902_4_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211215_1_v_0_akr1b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Diarrhea	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.518
BRD-A70931301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38348
sc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.126
BRD-K37696710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11299
Cytosolic large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.042
Decidual stromal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.688
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BARX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8691
Juvenile	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.028
Decidual cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.51
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.326
Xcp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.757
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.821
PMC10928104-41419_2024_6576_MOESM4_ESM.xlsx-S14-E2F1_2_3_targets_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
Plant tumor tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.994
Hair root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.774
Splenocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.458
BRD-K67442425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36893
CAL33_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	2.89124
CRCGN016_MCF10A.TP53.M_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30839
CRCGN016_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.34668
HMGB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14208
CC-03-PW00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.831746
mitochondrial membrane	GO Cellular Component Annotations 2025	1.0	null
Stipe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.31
BRD-K64860758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08994
Breast - Mammary Tissue	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.848846
CRCGN017_MCF10A.TP53.M_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.66275
Extensor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.227
embryonic growth retardation	IMPC Knockout Mouse Phenotypes	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.42651
Desipramine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
BRD-K92356505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56374
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K27372445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27724
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7169_RBM28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.822383
874_BOP1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.546935
BRD-K74611044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53826
BRD-K46805838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66363
CRCGN010_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10207
BRD-K17303020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02371
22RV1_PROSTATE	CCLE Cell Line Proteomics	1.0	3.59194
amidopyrine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04809
BRD-K26217579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98529
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K17133642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37998
Rosette	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.243
CRCGN017_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.69131
CRCGN015_MCF10A.TP53.M_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.13735
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.22042
CRCGN011_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3703
BRD-K05125666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89573
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.47591
7561_RRP12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.510272
CRCGN012_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33365
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.459
9210_TPP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.55383
GSE140441_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.56213
BRD-K26091803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34615
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.58685
Plastid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.04
BRD-K72648699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3609
BRD-K78809123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17421
GTEx Lung 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-8.87696
CRCGN010_HEPG2_24H:N07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.11532
GSE223287,GSE223290_2_v_4_braf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OSR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3155
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lacrimal apparatus disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
BRD-K68060538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.589
Primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.608
BRD-A84867566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13689
BRD-K98135954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52595
GSE227891_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K55895855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14181
BRD-K06219419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5935
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.139
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
ASAP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.554
CRCGN015_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.71037
Dorsal fin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.797
CRCGN016_MCF10A.TP53.M_24H:B23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13942
FBXO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22927
CTTNBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00634415
Glioblastoma	DisGeNET Gene-Disease Associations	1.0	null
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
B875 antenna complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.19
GB-57-XV52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287067
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.506
INS-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.538
CRCGN016_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.73085
CRCGN011_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2547
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.31966
BRD-K24838542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36361
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.65805
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.656
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1869
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.29253
SETX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30284
BRD-K11442063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38724
CB-82-PL01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271896
FB-32-PY27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.934078
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:B09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.40292
Pitcher	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.959
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9395
mitochondrial translational termination	GO Biological Process Annotations 2023	1.0	null
Nucleolus organizer region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.638
CRCGN016_MCF10A.WT.HP_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.68377
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K76976010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68793
BtuCD complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.131
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE242290_1_v_8_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05135707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97415
CRCGN013_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.92493
Cytosolic ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.713
CRCGN016_MCF10A.TP53.M_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3241
PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4A-Down_Nanog_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.686474
BRD-K50474387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56411
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.24742
BE-66-UB12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28888
SUPT7L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0050003
BD-69-GX17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212758
CRCGN008_HEPG2_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.444
Chloroplast inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.017
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.23125
SLC5A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555581
Meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.33
BRD-K23361743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27854
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.11781
RRM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00677424
BRD-K48188521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.45329
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243229
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.61592
GSE169356_2_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
preribosome, small subunit precursor	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.406
dbsfrhl2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.799
GSE147876,GSE147877_2_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:B09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11565
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.7
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7318
BRD-K15099225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27399
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.938998
BRD-K13007223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43284
Mesophyll	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.937
496100379_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03872
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.9762
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
9366_TSR2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.578655
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.75456
Root cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.88
BRD-K56250581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09654
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-D-Enh_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K82432417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1662
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5572
translational termination	GO Biological Process Annotations 2023	1.0	null
AP-1 adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.001
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25146
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295536
GSE115395_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K13265046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33513
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.848098
CRCGN015_HEPG2_48H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25996
Juice	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.19
CRCGN014_HEPG2_3H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.58088
TTT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.696
Presynaptic cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.37
MDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20902
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.14735
BRD-K09993756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0497
Extravillous trophoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.973
GSE252857_2_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.31936
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.879
Colon - Sigmoid	GTEx Tissue Gene Expression Profiles 2023	1.0	2.80339
CRCGN012_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54811
9482_UBA52_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.556929
FNTB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00665047
BRD-K90625628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65699
CRCGN016_MCF10A.TP53.M_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08845
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.867
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7892
Palpus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.474
PMC9601604-NIHMS1841143-supplement-SuppTable-2.xlsx-FOXO3-specific_targets-FOXO3-specific_targets_1218_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal embryo size	MGI Mouse Phenotype Associations 2023	1.0	null
GSE118490_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bipolar disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.316
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.416695
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1264
BRD-K66735533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16833
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
BRD-K05411364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29363
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.48915
PMC12753515-Table2.XLSX-G5-specific_down_only_top_500-EGR2_EGR2	Rummagene Transcription Factor Associations 2026	1.0	null
Mastigoneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.099
Biceps	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.302
ITGA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00469638
Esophagus - Gastroesophageal Junction	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.98214
Tibialis anterior	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.138
BRD-K89328601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13276
H2AC12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00497166
Critical illness polyneuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
5548_NDUFAF5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.845777
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.298
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN008_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.6047
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.59203
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.85601
874_BOP1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.566069
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.829551
GSE158320,GSE183351_2_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K44760023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03238
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.313351
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.06755
BRD-K55853030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62627
7522_RPS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.556879
Endoplasmic reticulum-Golgi intermediate compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.984
FF-28-ES17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.763094
Xylem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.197
Toe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.778
GSE48812_7_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
ETFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12219
Heart - Left Ventricle	GTEx Tissue Gene Expression Profiles 2023	1.0	1.75418
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-GM12878_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K60437668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04063
GSE158320,GSE183351_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K21420222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01853
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.841
CRCGN011_HEPG2_24H:D24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38055
7449_RPL23A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.630804
CCDC88C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80771
BRD-K88200990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13102
Taproot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.706
DB-88-VW47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.408353
Chloroplast membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.046
BRD-K14778436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62533
Endodermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.589
GSE113106_2_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143406_1_v_0_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-99-SN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267797
CRCGN010_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10795
BRD-K92544320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28773
aminoacyl-tRNA hydrolase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K42605555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16164
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.30195
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16539
BRD-A69110668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01648
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.6223
Hodgkin's lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.071
Autosomal recessive spinocerebellar ataxia 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.45
Chromosomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.713
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.82747
PMC12769604-13402_2025_1147_MOESM6_ESM.xlsx-Table_S4_3_Venn-Scissor_AND_Prognosis_NOT_Tumor_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
SLC13A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00627462
XE-69-AT35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226485
BRD-K85055578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77359
CRCGN017_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.86695
CRCGN015_MCF10A_48H:E12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5103
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.97709
BRD-K25649458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50128
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9024
CRCGN015_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0261
GSE190384,GSE190386_3_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
2127_DDX51_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.501706
BRD-K22485581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20384
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56435
Hoof	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.509
CRCGN015_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.74597
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30725
GSE227891_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5339
PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Unnamed_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
DC-51-WE27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.381647
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2082
PMC8355885-gutjnl-2020-320652supp004.xlsx-RALY_KD_mRNA-seq-Table_3_RALY_Knockdown_in_HCT116_cells_mRNA-seq_log2_FC_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Connective tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K42671261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31921
Hair	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.378
GSE190076_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11615365-41467_2024_54246_MOESM6_ESM.xlsx-KK47-Numb-KD_vs_Ctr-KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K36252987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52713
rt1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.859
Mitochondrial large ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K19969409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26279
DF-00-DK69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.602902
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.70271
Urethral calculus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.4
BRD-K78907873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54979
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE62843,GSE64371_2_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.57876
PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Genes_up-regulated_in_Miz-1_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K17234088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41358
FA-88-II68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239975
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.522
Mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369869
5657_NFYB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.61994
BRD-K28080909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11431
CRCGN016_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27245
5731_NOC4L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.696776
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_2_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
TFDP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.0349
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.51705
GA-88-CF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.428038
GSE223893_11_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.18565
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.29694
BRD-K82394273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00522
CRCGN011_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5384
BRD-K62256869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07184
BRD-K09842906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26693
Adventitious root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.788
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.377079
HOXB13-26457646-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K27889081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33003
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.513
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
AB-18-YN11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.546776
Anterior cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.883
GSE167224,GSE168147_3_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.77868
Schizoaffective disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.286
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233914
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.50815
Aerial part	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.777
J558L cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.543
GSE137144_5_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TIM23 mitochondrial import inner membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.8
GSE217541,GSE217543_0_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
2225_UTP25_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.517823
CRCGN015_HEPG2_48H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0178
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HMGN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18699
Tepal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.083
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.96174
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-8.38175
GSE125403_3_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
PADI6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00473961
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Quadriceps	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.179
EFTUD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18392
BRD-K26559753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15753
CRCGN017_MCF10A.WT.HP_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3481
BRD-A21524347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40669
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.84645
BRD-K26872015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17036
BRD-K22093970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08683
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.535
BRD-K41809257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14188
Vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.379
BRD-K44624253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29625
BRD-K80888333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74227
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.646044
Insect labium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.312
Tongue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.4138
BRD-K30799912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94527
Lupus erythematosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
Cob	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.583
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pneumonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.298
hTERT-HPNE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.629
BRD-K84235037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95083
BRD-K82671459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81557
CRCGN014_HEPG2_24H:H21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0626
BRD-K95653016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22332
mc2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.896
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.31124
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0241
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9314
BRD-K12866026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20486
DCAF12L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34472
BRD-K17449871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15095
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.02008
BD-18-MM33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223659
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.544
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2547
COPII-coated ER to Golgi transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.967
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33973
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.585
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229078
AB-11-AY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264511
Plasma membrane light-harvesting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.987
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4647
CRCGN016_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.46363
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_9_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Eating disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92440102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1586
GSE143462_0_v_1_omipalisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259108
BRD-K21990363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36008
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AE-88-WQ63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233532
7459_RPL31_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.770274
CRCGN017_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.79115
CRCGN014_HEPG2_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56028
RQC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.982
BRD-K99529078	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0505
BRD-K49704392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49259
BRD-K80895505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15966
BRD-K86143816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14562
BRD-K24422491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78823
BRD-K32000549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06043
CNOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23735
WC-09-GD62_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336743
Pollen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.378
GSE110178_1_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11161988-12906_2024_4523_MOESM3_ESM.pdf-82-IRX3_IRX3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K46715415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29483
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.56859
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.41365
PMC10830421-41589_2023_1452_MOESM5_ESM.xlsx-HEK293T_MAX-Tg_tissues-Unnamed_0_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.642
CRCGN008_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.87775
CRCGN011_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1838
Plasmacytoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.83
BRD-A12894472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02165
Taurine dioxygenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.025
OB-78-PA58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.12576
CE-15-YU05_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.69756
peg16	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.392
CTTNBP2NL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0107
cls1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.953
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200008
BRD-K45112293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17679
BRD-K99859971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1713
GSE206270_2_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE256181_1_v_3_etv2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K93846199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21787
Stoma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.062
BRD-K60509482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0486
GSE189941_1_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K83801418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18329
GSE229309,GSE229314_4_v_1_elavl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.27262
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.1223
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.77276
DC-08-CM08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.753309
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5249
CRCGN015_MCF10A.TP53.M_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1747
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.41778
Large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.019
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.431
Mucocyst	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.507
SUPT3H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75178
BRD-K58242935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3803
Supportive connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.328
ARFIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76647
BRD-K28700379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7573
BRD-K26402831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37995
Follicular dendritic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.798
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7769
PMC4975902-12864_2016_2842_MOESM12_ESM.xlsx-targets_of_IRF8_in_NSCLC-COX7C_IRF8	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8593586-mmc2.xlsx-LIN28A_interactome-Unnamed_1_LIN28A	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1655
Brachial Amyotrophic Diplegia	DisGeNET Gene-Disease Associations	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.395
Preribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.291
BRD-K11003742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0027
MAP3K3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10533
BD-22-KS33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247562
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.757666
Ophthalmoplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
CBX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14091
High myopia-sensorineural deafness syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.178
Mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.486
CRCGN017_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.03157
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
8842_TFCP2L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.506036
Mitochondrial translation	Reactome Pathways 2024	1.0	null
PMC4332150-msb0011-0775-sd13.xlsx-JUN-Prey_Gene_Symbol_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A17831693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0274
GSE165071,GSE165072_1_v_0_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Bacterial degradosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.894
BRD-K16551475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04373
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.354534
5964_LTO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.532144
LY86	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00593355
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
aminoacyl-tRNA hydrolase activity	GO Molecular Function Annotations 2025	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7878
CRCGN016_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7312
BRD-K82175530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00149
GSE224131_3_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
Large B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.306
Alkanesulfonate monooxygenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.453
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.31142
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_10_ZZZ3_ChIP-seq_in_shNT-Nearest_TSS_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.80699
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.03621
BRD-K25709301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40433
GSE193993_1_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_12_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN010_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.01046
CRCGN009_HEPG2_24H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.35607
BRD-K35156336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10134
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.21976
bsc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.525
STK10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04069
BRD-K25907192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9279
Intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
TLK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532784
CRCGN008_HEPG2_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.32465
PMC12823428-43587_2025_1018_MOESM3_ESM.xlsx-ST12-Supplementary_Table_12_Main_mendelian_randomisation_results_of_plasma_proteins_on_delirium_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K25199508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77716
PC-62-AQ92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.21675
f7000	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.989
Bronchial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Dry eye syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.710439
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.05231
BRD-K92358687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92267
GSE114258_1_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.87483
BRD-K11423211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29206
BRD-K93747042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28707
GSE146982_7_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cellulosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.634
CB-06-FE89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24788
CRCGN016_MCF10A.WT.HP_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.1035
ae2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.611
small-subunit processome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.733
PMC12515692-MOL2-19-2882-s005.xlsx-Proteome_AKT1_AKT2_KD_vs_SCR-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
HOXA7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.4973
GFM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50252
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K54872884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32385
Leaf primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.675
BRD-K58688519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04612
Leaf epidermal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.904
BRD-K05475322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58652
Mitochondrion	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
BRD-K17553044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55753
Metatarsal bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.871
GPR162	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63849
GSE111247_11_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07479
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.339
Plastid acetyl-CoA carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.735
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9257
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.376
GSE198380_0_v_1_phgdh_human	RummaGEO Gene Perturbation Signatures	1.0	null
7476_RPL6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.832724
GSE159728,GSE159730_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Panic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
CRCGN017_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.69005
BRD-K31197843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81018
BRD-K84586608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3617
Parietal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.269
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.19645
GSE147876,GSE147877_2_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.117
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.32625
GSE148657_2_v_1_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4335056-pone.0116726.s005.xlsx-X-ChIP_NOT_TX100_QE-GENE_Official_symbol_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K16432886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25046
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13687
CRCGN012_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10821
B-lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.108
MT-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.902
CRCGN015_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.46305
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
GSE214931_4_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.94901
GSE129465_3_v_2_phf6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Rucaparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140817
Organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CRCGN010_HEPG2_24H:P18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06623
7450_RPL23_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.637872
CRCGN008_HEPG2_24H:E05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70085
GSE114258_3_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.473
Personality disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.658
interleukin-7 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.859
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21921
7569_RRS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.576494
KNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.822
CRCGN009_HEPG2_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33489
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5417
CRCGN016_MCF10A.TP53.M_24H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56335
BRD-K85919350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21772
BRD-K56188108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36889
Calcitonin family receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.743
Mitochondrial ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
MIS18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00923
6534_POLR1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.663633
GSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.1865
BRD-K68314790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11271
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
BF-44-HD37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333097
Mis6-Sim4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.727
CRCGN012_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.86433
PRRX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3559
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.223
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.603196
GSE124920_1_v_2_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.23785
Activin responsive factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.585
Ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.165
BRD-K07839394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17361
PMC6078963-41467_2018_5311_MOESM5_ESM.xlsx-48h_KD_UP_Vs_ATAC-mgi_database_human_gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Demyelinating disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
DA-81-VY50_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231593
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K08311368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19314
Fatty acid elongase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.675
Plant bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.093
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.346
GSE109140_2_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE208350_4_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K16954129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11434
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K13113551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7222
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.26797
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.54555
BRD-K01754917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46733
clone9	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.648
Dravet syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.145
1040_C1ORF131_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.609094
QD-39-YV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302927
BRD-K36298208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2327
CRCGN012_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1707
PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_0_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE113952,GSE113953_1_v_0_chtop_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6596
JD-10-HW02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207256
BRD-K79152256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14007
JE-55-OJ53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205661
Organellar ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.584
BRD-K89300187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50804
Corneal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
HOXD12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9797
GSE235701,GSE261434_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2545_EIF3B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.527781
BRD-K58248556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.72991
BRD-K44139682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26969
B800-820 antenna complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.536
PMC11511861-41420_2024_2216_MOESM2_ESM.xlsx-GSEA_siYAPsiTAZ-SITAZ_UP__MYC_EZH2_H3K27M3BOUND_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Chronic tic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.091
CRCGN015_MCF10A.WT.HP_24H:I22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.07061
BRD-K37510443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20905
CRCGN017_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.83329
Plant primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.88
GSE239844_6_v_12_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1686
BRD-K34620971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33604
BRD-K79965790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22947
8656_TAF1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.555605
BRD-A61014366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23262
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.906695
BRD-K02240568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08333
CRCGN017_MCF10A.TP53.M_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12558
GSE202434,GSE202438_3_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.90415
New cell pole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.512
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PC-18-VX23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.965306
Uths	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.073
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342489
LHX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5955
BRD-K35383890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.774
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.95564
7476_RPL6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505421
GSE235390_4_v_0_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7444_RPL19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.802882
CRCGN015_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.95395
Primary Malignant Neoplasm Of Lung	DisGeNET Gene-Disease Associations	1.0	null
Seedling	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.904
CRCGN014_HEPG2_3H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.98209
BRD-K20520611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27405
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.87483
BRD-K27540772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34278
Bile	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.918
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.192
BRD-K29143088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44986
BRD-K05940224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32943
CA9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00527581
Mitochondrial metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.245
Clathrin coat of endocytic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.695
GSE203158_0_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
l23	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.527
BRD-K14122415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0659
CRCGN012_HEPG2_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.52299
DA-27-BW20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.592427
DF-00-BX35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219104
Sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN012_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50156
CRCGN017_MCF10A.WT.HP_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5566
Root apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.741
Nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
7451_RPL24_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.653428
CRCGN016_MCF10A.WT.HP_24H:F23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65892
GSE203158_0_v_13_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PC14_LUNG	CCLE Cell Line Proteomics	1.0	2.00409
Tetanus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.284
BRD-K96652989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66263
Tail fin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.794
PMC12289921-41467_2025_62099_MOESM4_ESM.xlsx-MI-2-80-Gene_Symbol_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE192870_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mitochondrial translational termination	GO Biological Process Annotations 2025	1.0	null
HIPK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00499776
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.794362
Vastus lateralis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.768
BRD-K67715154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19545
Glume	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6515
GSE121866_0_v_2_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GD-46-BU97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.602251
FRAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64051
Pectic matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.888
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.34817
Anxiety disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.554
BRD-K92712225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30187
MWP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.817
Periplasmic flagellum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.751
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.60687
Nymph	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.835
GSE201668_0_v_1_ncor2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K43192646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26616
Distal arthrogryposis type 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
RISC-loading complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.656
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.680134
CBX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00433565
CRCGN014_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.19147
PMC5795782-supp_gad.302646.117_Supplemental_Table_S1.xlsx-Table_S1_2-Supplemental_Table_S1_2_Genes_significantly_upregulated_by_ARID5B_knockdown_ARID5B	Rummagene Transcription Factor Associations 2026	1.0	null
Mitochondrial fatty acid beta-oxidation multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.545
MCF7_Tucidinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130623
ml3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.635
90S preribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.178
BRD-K53354260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05274
PMC11511861-41420_2024_2216_MOESM2_ESM.xlsx-siTAZ_myc_bound-MYC_targets_from_chipseq_atlas_at_least_2_chip-seqs_over_4_in_A459_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.511261
BRD-K05704547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06401
BRD-K94378105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23711
BRD-K98276754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67345
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49323
BSX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.4422
TA-57-FF07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219191
PLEKHM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570994
Plasma membrane-derived chromatophore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.95
Endosperm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.105
BRD-K93998074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11824
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.48196
Mature stage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.183
CRCGN014_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2145
SMARCB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00428122
DC-23-UM36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.466304
GSE199606_1_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7902
Pellicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.61
Golgi transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.21
Stele	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.237
CRCGN016_MCF10A.WT.HP_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04801
BRD-K43108627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09162
translation	GO Biological Process Annotations 2023	1.0	null
GSE148321,GSE169423_2_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6811
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23475
CRCGN014_HEPG2_24H:A05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.39538
BRD-K65399214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68234
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.29015
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
SPECC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08191
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE255432_7_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CDK9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54447
CRCGN010_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05993
HB-75-KT12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299895
Gastrocnemius	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.237
Distal arthrogryposis type 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.798
Spikelet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.078
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.3021
Plant ovary	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.876
ARID1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00557417
Vermiform appendix	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.243
BRD-K92950328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36763
GSE90710_1_v_0_med13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.26816
Vascular bundle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.21
CRCGN016_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.339
BRD-K39131701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33359
phenylalanine-tRNA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.592
Corolla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.015
6534_POLR1B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.636138
EN2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5279
BRD-K12239796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18288
CRCGN013_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.65648
QA-07-KC40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.497555
Bardet-Biedl syndrome 13	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.874
Narcissistic personality disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.133
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.353
7466_RPL36_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.614591
Organellar large ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE184902_4_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.35477
BRD-K27997230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12524
MKS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.038
CRCGN017_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5145
Hepatoblastoma	DisGeNET Gene-Disease Associations	1.0	null
Prostate	GTEx Tissue Gene Expression Profiles 2023	1.0	2.96144
ribosome disassembly	GO Biological Process Annotations 2025	1.0	null
Human immunodeficiency virus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
FAM167B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90242
deferoxamine-mesylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61413
Bursa copulatrix	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.981
Leaf collar	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.622
Organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Endoplasmic reticulum palmitoyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.288
BRD-K28995832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58811
GSE62843,GSE64371_4_v_0_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE183335,GSE183351_3_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
7481_RPL9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.50157
GSE158834_2_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.36237
CRCGN015_MCF10A.TP53.M_24H:D10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00285
Cytoplasmic exosome (RNase complex)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.937
CRCGN009_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2297
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.83599
CRCGN016_MCF10A.WT.HP_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14961
GSE112763,GSE112767_0_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500306
CRCGN009_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.44447
Fin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.021
BRD-K97741413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12716
GSE248770_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BE-68-PM13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271932
Stat6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.1825
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.105
BRD-K95459450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31236
BRD-K94766933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25344
GPR20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15046
BRD-K31250130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.25839
XC-61-SE50_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.561792
CRCGN016_MCF10A.WT.HP_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.15195
4684_LSG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.540574
NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.85531
Hybridoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.66
Contractile vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.647
LA-69-OL77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203975
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.327
CE-95-YX02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.353606
Adipose tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE206516,GSE206518_6_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Clathrin coat of trans-Golgi network vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.0
GSE73562,GSE73563_1_v_2_preb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Plastid pyruvate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.831
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
Dentin caries	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.612
WB-54-WD35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247912
Secondary cell wall cellulose synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.712
BRD-K27132686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06673
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.88051
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01515
GSE158834_0_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE138468_3_v_6_dyrk1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7469_RPL38_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.763399
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.9898
GD-46-BU97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212865
CRCGN013_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53073
MFE296_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	3.81383
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19045
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.275
CRCGN012_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12689
BRD-K51927648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47003
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.398329
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00939
BRD-K82619993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13019
CRCGN008_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1672
PMC3470785-NIHMS377161-supplement-3.pdf-273-ALX4_ALX4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Rto	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.831
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.28115
GSE252857_2_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K78762661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20561
CRCGN016_MCF10A.WT.HP_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.39786
BRD-A57536034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27529
BRD-K40221630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06456
BRD-K92456318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68277
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.37565
b18	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.894
BRD-K03476091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35677
496100594_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.47074
6798_PRPF40A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.653612
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.689297
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.2076
Caryopsis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.088
S0-EE-YC7H_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216531
FB-24-UT80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334213
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-81-VY50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269624
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.9443
archaeal-type flagellum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.944
GSE70499_3_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pectoral fin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.648
Tendril	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.594
CRCGN016_MCF10A.TP53.M_24H:P18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.44272
CRCGN015_MCF10A_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32435
Huh-7.5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.511
CRCGN015_MCF10A.TP53.M_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23936
PMC10311050-mmc2.pdf-107-ENSG00000171223_JUNB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K45172622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32303
Visual cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.034
Roe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.154
EA-18-FP00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.17152
IC-18-TY61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.419063
CRCGN017_MCF10A.WT.HP_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20255
BRD-K97348029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79676
BRD-K30462643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58907
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.31337
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6176
cytochrome-c oxidase deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.306
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDH11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00592351
NE-20-WM78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.66402
CRCGN017_MCF10A.TP53.M_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.5988
Exosome (RNase complex)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.929
BRD-K26435104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04983
BRD-K70407915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02409
Schizophreniform disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.227
BRD-K11399565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90597
Chloroplast envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.032
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K03381861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02028
preribosome, large subunit precursor	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.236
Thigh	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.363
Optic atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.509529
BRD-K01467488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42099
Communication disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
IFT80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53331
BRD-K12431811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42056
CRCGN015_HEPG2_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0087
Postpartum depression	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.007
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5559
ChaGo-K-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.958
CRCGN016_MCF10A.TP53.M_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03977
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.86119
CRCGN017_MCF10A.WT.HP_24H:M24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3673
Fruit	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.715
GSE137144_3_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K95672449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49743
PPP2R1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14774
CRCGN013_HEPG2_24H:F15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5801
BRD-K53548223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27524
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.307
Root tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.414
GSE153867_6_v_4_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Parasitic protozoa infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
7443_RPL18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.510879
NKX6-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.6267
PMC5692555-pnas.1708341114.sd04.xlsx-3TFs_no_GATA2-gene_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
PIGV	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00532004
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Golgi-associated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.322
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.64312
BRD-K60454848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02032
RAJI cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
Gluteal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.901
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.10875
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.707
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5323
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.04413
BRD-K19645475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82976
GSE168797_2_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K82774801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17712
MA-104 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.609
CRCGN014_HEPG2_3H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.39346
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.5707
CRCGN012_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.40863
BRD-K42139332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2508
BRD-K50190949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19136
TBCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.92253
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.15874
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.360884
CRCGN011_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.10155
BRD-K69585439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17867
BRD-K68119260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43568
T-REx 293 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.838
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.72858
AC-55-XA97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.37608
Rix1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.107
CRCGN015_MCF10A_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.43615
Carpel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.449
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.405
BB-23-PM31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225565
TAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19465
Acrosomal matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.828
CRCGN011_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0757
Gill raker	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.299
7463_RPL35_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.721133
embryonic growth retardation	MGI Mouse Phenotype Associations 2023	1.0	null
Rovs	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.092
BRD-K32706281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54611
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.2656
WC-82-YS26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.321506
7525_RPS3_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.602184
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.53782
BRD-K56075657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73241
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.6004
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Corpus cavernosum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.753
Petal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.234
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.403
PMC12529848-12967_2025_7217_MOESM3_ESM.xlsx-Table_S4-Table_S4_Associations_of_genetically_proxied_proteins_with_risk_of_atrial_fibrillation_by_MR-SPI_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
French Canadian Leigh disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
2983_FAU_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.543572
GSE202434,GSE202438_13_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.367
lm1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.084
COPI vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.131
BRD-K75410936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05007
Organelle inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Nrd1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.02
ac2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.574
Microspore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.858
RPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82686
Planktonic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.608
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.29926
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376688
BRD-A23193246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41069
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.366
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.548153
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
translational termination	GO Biological Process Annotations 2025	1.0	null
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.297
BRD-K40252598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24397
COVID-19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.652
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9831
CRCGN013_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53649
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cell cortex region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.351
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_1_ZZZ3_ChIP-seq_peaks-Genebody_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K62213484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22828
BRD-K22139757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3387
GSE216043_11_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_11_ZZZ3_ChIP-seq_in_shZZZ3-Nearest_TSS_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
Aleurone layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.086
AC-47-YZ27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.77186
SEZ6L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35767
Pulvinus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.509
CRCGN017_MCF10A.TP53.M_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5429
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.09955
Organellar small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.575
Plastid envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.024
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3015
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Acquired immunodeficiency syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
ZNF275	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24248
Non-Small Cell Lung Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K54112192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20816
GSE122509,GSE122513_2_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CENPV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1662
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.516
CRCGN013_HEPG2_24H:B07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49513
BRD-K19817946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2458
7312_RIOK2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.569931
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75483
TCF21-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.410554
GSE190384,GSE190386_1_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216147_0_v_3_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
ARID5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09464
Decidua basalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.656
IgM immunoglobulin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.011
Mitochondrial small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.576
BRD-K03675705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.43498
BRD-A27080191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1673
CRCGN008_HEPG2_24H:I15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.67075
BRD-K31275250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35888
Adrenomedullin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.522
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.427
GSE188869,GSE188871_2_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mandible	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.062
detroit551	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.772
GSE158834_10_v_8_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K11457257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98193
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Secondary cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.893
Chloroplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.682
BRD-K21196859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28386
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.51562
CRCGN017_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08603
Cuboid bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.741
7389_RNF34_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.542467
CRCGN010_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43615
GSDMD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22666
BRD-K78574327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05525
AA-58-FJ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.81466
PMC7576810-41419_2020_3099_MOESM9_ESM.xlsx-MS_analysis_EVI1-WT_vs_EVI1-S43-Unnamed_0_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
gk1.5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.665
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23884
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.530039
CRCGN016_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.31915
BRD-K69229416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40153
CRCGN015_MCF10A_48H:L06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8763
NME8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00582974
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.66941
CC-03-PW00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.80208
CRCGN015_MCF10A.TP53.M_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1499
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.68595
A549_Decitabine_1µM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0111883
BRD-K10459972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83461
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.793
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.07108
2543_EIF2S3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.596366
CRCGN011_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47605
Mesophyll cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.912
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K33497830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90428
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K69154646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72494
Carapace	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.194
Translation release factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.567
GSE125014_6_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MNX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.4988
Cotyledon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.127
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.532981
BRD-K21996934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20154
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8724
Arid3b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.2144
BRD-K61027868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68775
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.554463
CRCGN016_MCF10A.TP53.M_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30474
intracellular organelle lumen	GO Cellular Component Annotations 2023	1.0	null
BRD-K69152679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11819
BRD-K21355275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02901
BAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88505
Substance abuse	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.773673
Endoplasmic reticulum exit site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.791
GSE124410_3_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.72285
PMC11109217-41420_2024_2017_MOESM3_ESM.xlsx-Fig_4H_TAF2-bound_genes-Tag_dentsity_of_TBP_ChIP-seq_signal_for_TAF2-bound_genes_in_Fig_4H_TBP	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7504
AHDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18035
Golgi cisterna	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.005
3537_GRINA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.06369
POFUT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0059148
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.06459
BRD-K26161397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42288
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.08252
GSE158834_2_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7616986-EMS181817-supplement-Supplemenatry_tables.pdf-557-E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
7466_RPL36_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.665606
PSMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10003
ENY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05466
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lateral root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.892
BRD-K24387453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0477
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.802
GSE217541,GSE217543_3_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K02290471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03533
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.14706
PCDHGC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07247
BRD-K86545229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22857
7450_RPL23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505378
7462_RPL35A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.561638
GSE158834_10_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Fruit capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.115
7432_RPL10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.609649
HSPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28328
6493_PNO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.742975
BRD-K91426044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01051
CRCGN016_MCF10A.WT.HP_24H:B06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4506
Ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
ANAPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18764
BRD-K86848211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37291
CRCGN015_MCF10A_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.90547
CRCGN017_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.39769
Combined oxidative phosphorylation deficiency 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.58
LMSU_STOMACH	CCLE Cell Line Proteomics	1.0	2.60759
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4221
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3781
BRD-K78828094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09123
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.011
d17	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.586
BRD-K31889353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43259
Anus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.755
BRD-K65969715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12176
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Salivary gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.079
CRCGN017_MCF10A.WT.HP_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.63747
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8952
PMC9136613-mmc2.xlsx-Supplementary_Table_S1B-Supplementary_Table_S1B_PRECOG_survival_score_for_HSF1_targets_in_the_OS_dataset_GSE16091_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09697
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-D-Enh_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Borrelia miyamotoi disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
X-linked cardiac valvular dysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
Apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.173
CRCGN015_MCF10A.WT.HP_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75008
GSE228413_2_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LMX1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6581
GSE182680,GSE182683_10_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11291976-41423_2024_1195_MOESM10_ESM.pdf-29-NFATC1_NFATC1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Distal arthrogryposis type 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
hFOB 1.19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.624
Behr syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RD-90-OY66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.01723
Mitochondrial matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.023
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
separase-securin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.804
Extrastriate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.579
GSE146045_1_v_0_lama3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.9747
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.93789
BRD-K44497547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7609
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3929
Autoimmune disease of central nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.33267
Hairy root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.974
7479_RPL7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.551823
Wart	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.512
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0918
BRD-K70533557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59913
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE247862,GSE247863_0_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K52094743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7507
BRD-K74987024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16124
MSC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23851
Mongolian spot	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.174
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2076
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_3_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223241_2_v_0_cdkn2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160304,GSE163392_0_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206516,GSE206518_3_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE144231_3_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8387919-mmc2.xlsx-ST2_NEUROG3_binding_sites-Unnamed_13_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K09388706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80633
BRD-K31273080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69831
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.52851
CRCGN016_MCF10A.TP53.M_24H:A21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03318
Temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.944
CRCGN015_MCF10A.TP53.M_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.11695
Adrenal Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.658427
CRCGN011_HEPG2_24H:N05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23755
PC-62-AQ92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.03023
RPAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0226
BRD-K79433629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58461
FB-66-UU47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.878094
GSE153443_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
c2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.503
Intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.455
CTDK-1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.671
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8885
GSE215351,GSE215794_4_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
translation	GO Biological Process Annotations 2025	1.0	null
louse-borne relapsing fever	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.289
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
b21	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.718
CRCGN014_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.7421
CRCGN014_HEPG2_3H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4889
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.384
DUS3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20478
Sclerenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.397
GSE224294_1_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	43.5981
Seta	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.426
BRD-K34931072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61033
CRCGN010_HEPG2_24H:E14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.48821
FD-29-MM50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222162
Shoot apical meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.961
BRD-K34009761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0084
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.93412
Cuticle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.315
L-1210 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.561
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.90125
BRD-K53647637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84406
Acrofacial dysostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
Somatic embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.526
GSE148066,GSE157787_11_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50171760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27615
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K25016708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13305
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.3776
VD-76-SO91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252898
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.517552
CRCGN014_HEPG2_24H:P09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01524
CCNA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11965
TNFRSF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00592984
BRD-K70935154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07456
Vegetative stage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.095
Axillary bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.549
Delta1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.132
GINS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14245
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TEAD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5005
GSE239541_11_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SLFN12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24511
GSE206784_2_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	3.46244
FB-39-CW59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289983
Leaf lamina	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.494
Acute diarrhea	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.18
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.523934
HOXB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0352
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7871
BRD-K39668479	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96199
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.0482
Fruit juice	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.758
CHD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00335404
PMC5651844-41467_2017_1173_MOESM7_ESM.xlsx-ZZZ3_ChIP-seq_peaks-Unnamed_6_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.622538
BRD-K72351789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21784
Organellar ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
AE-17-IZ62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256343
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE181003_1_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Osseous plate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.578
Sporangium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.032
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09593
Tear	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
monolayer-surrounded lipid storage body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.366
BRD-K93491540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61142
GSE213588_8_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Weyers acrofacial dysostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.328
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	4.22319
Nde	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.702
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
SA-31-VB03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.34766
SA-32-CC58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.459517
Biceps femoris	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.432
u	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.511
PMC4909989-ncomms11840-s2.xlsx-up-regulate-The_YAP_TEAD4-FL_YAP_TEAD4-S_and_YAP_RBM4_regulated_genes_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Tuberculosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.902
Semitendinosus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.582
Imago	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.764
GSE120413,GSE120447_4_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K12347309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58986
GSE140607_1_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lateral entorhinal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.698
carboxylic ester hydrolase activity	GO Molecular Function Annotations 2025	1.0	null
GSE211286_4_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lymphoid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.00172
BRD-K25761766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30583
CRCGN016_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.13586
Meningitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
BRD-K02946901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34815
RMI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95034
BRD-K15047839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78028
BRD-K88997070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2511
Inflorescence meristem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.751
CRCGN012_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8502
PSMG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44442
BRD-K44402256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07401
BRD-K70804088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27427
BE-79-QU25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.729489
CRCGN015_MCF10A.TP53.M_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.82585
Flag leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.206
Mitochondrial translation initiation	Reactome Pathways 2024	1.0	null
BRD-K76984291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15852
Grm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
ISL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.818
CRCGN016_MCF10A.TP53.M_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05004
CRCGN008_HEPG2_24H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2103
BRD-K74754874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65003
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
mopc31c	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.982
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.441
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04479
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2377
c16	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.554
BRD-K81206010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58904
BRD-K06174863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65409
catalytic activity, acting on a tRNA	GO Molecular Function Annotations 2025	1.0	null
GSE234637_3_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8494348-pone.0257161.s002.xlsx-only_OXT_NOT_ext-OXT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Tuber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.796
GSE62843,GSE64371_2_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PABPN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0068373
Noc complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.049
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200352_9_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.06987
BRD-K64425085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36801
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-Mor_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
THBD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00741549
CRCGN017_MCF10A.WT.HP_24H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.056
Exocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.079
RRAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1492
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4090731-bjc2014262x1.xls-Sheet1-CaSig3-HSF1_Positive_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
Mitochondrial translation termination	Reactome Pathways 2024	1.0	null
Ppes	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.662
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.2243
Childhood Leukemia	DisGeNET Gene-Disease Associations	1.0	null
WEHI-231 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.827
SOX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00087
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K67666705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73104
Autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.385
CRCGN015_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.62485
Social phobia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
BE-25-UR78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277097
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.171
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.92629
GSE101527_3_v_2_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OF-05-CB18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.849564
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.688619
CRCGN017_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.79035
7166_RBM25_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.675796
10029_ZC3H8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.549377
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CE-72-GF32_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202384
BRD-K60531990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09029
Golgi membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.565
BRD-K77797589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1513
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.55721
CRCGN014_HEPG2_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6334
n92	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.077
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.953
BRD-K10130686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60872
BRD-K31503053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06083
CRCGN017_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.0779
GSE111138,GSE111149_1_v_0_runx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_2_ZZZ3_occupied_genes-ATAC1_bound_genes_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
Sapling	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.013
6274_PHAX_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.511968
C3orf62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79681
LYRM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03407
BRD-A61778798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00687
BRD-K44935022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06661
GSE216043_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE232564,GSE232566_0_v_2_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.635
Bone marrow	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.006
BRD-K47998973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62346
STK17A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45664
Rce	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.852
BRD-K26479796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38857
Root caries	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.3255
BRD-K15876355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52544
BRD-K60781525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10298
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.506
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53319
GSE138672_0_v_1_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Flower	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.058
4149_INTS4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.58448
PMC10247733-41408_2023_863_MOESM4_ESM.pdf-600-ZNF174_ZNF174	Rummagene Transcription Factor Associations 2026	1.0	null
TADA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69777
BRD-K09468701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44216
BRD-K21412601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28761
CRCGN017_MCF10A.WT.HP_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.92633
GSE122509,GSE122513_3_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Sleep disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
decreased bone mineral density	MGI Mouse Phenotype Associations 2023	1.0	null
f96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.119
BRD-K23503923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61797
Guard cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.669
Pupal wing	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.604
BRD-K02625776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17735
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.03385
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1619
BRD-K45400577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37793
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.53816
Mitochondrial large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.382
CRCGN017_MCF10A.TP53.M_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.49115
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.333892
AA-56-JY17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236695
SLC47A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00488018
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.543643
CRCGN010_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4673
BRD-K82249895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42707
GSE48812_7_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Leaf disc	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.188
TF-77-DW08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.5495
DDX41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4417
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221633
BRD-K11705648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23296
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234711
Measles	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
BRD-K77869064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10595
GSE158834_7_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Elytron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.188
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
Mitochondrial matrix	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Nuclear pore linkers	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.658
GSE193541_0_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
Adult Diffuse Large B-Cell Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-A89471191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05353
BRD-K14534138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06591
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.594
GSE151782_3_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
QE-76-ST29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26318
BRD-K97526959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57673
BRD-K60161601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13595
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perianth	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.083
BF-94-CQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223542
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.59537
BRD-K84559549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0388
10722_ZSCAN2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.649892
Diffuse Large B-Cell Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
GSE184884_7_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.85008
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.30623
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
trans-Golgi network transport vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.0
GSE203158_0_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K47143916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53689
Coated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.371
JB-75-NC66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.387854
9656_USP39_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.585559
8826_TEX10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.708666
SIAH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00402234
CRCGN012_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.70732
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.5736
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.31444
KB-92-MK13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.276682
Vastus medialis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.869
496100297_FWM_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.09301
FD-86-NE74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.593419
CRCGN015_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.37185
decreased hematocrit	IMPC Knockout Mouse Phenotypes	1.0	null
HIF1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00282409
ZB-16-BR73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.423576
BRD-K00081911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.08036
Loeys-Dietz syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.395
BB-79-AG41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.360447
Foramen magnum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.73
BRD-K27373956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01983
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-20-UU03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.944782
mitochondrial gene expression	GO Biological Process Annotations 2025	1.0	null
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.32788
CRCGN015_MCF10A.WT.HP_24H:N22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2377
Neonate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.426
tick-borne relapsing fever	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
Column	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.163
Endocarp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.689
Plant candle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.755
BRD-A06149038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21855
PMC12824661-BLOOD_BLD-2024-027020-mmc6.xls-Table_S14-HES4_Down_HES4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE81796_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.3926
Macronucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.559
Egg white	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.796
BD-93-AM31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202716
CRCGN015_MCF10A.WT.HP_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.19214
PMC10928104-41419_2024_6576_MOESM4_ESM.xlsx-S14-E2F4_5_targets_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
RA-49-ZB08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305589
CRCGN017_MCF10A.WT.HP_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1698
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.38745
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.994
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.46201
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.712909
DPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.038
Distal arthrogryposis type 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.253
BRD-K11687039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.349
CRCGN017_MCF10A.TP53.M_24H:N18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40831
GSE112761,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
c96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.183
BRD-K88384015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01629
496100310_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01256
CRCGN014_HEPG2_3H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.71112
AKAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29046
BRD-K74600148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15031
GSE252857_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21549
Germinal center	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.256
BRD-K56650430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18956
Cytoskeleton of presynaptic active zone	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.371
GSE225218_0_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Claw	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.713
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.07308
Rind	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.526
Flexor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.422
Middle temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.545
Cervical mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.435
BRD-K05885800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18473
CRCGN009_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43865
Yy1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.3071
GSE201239_3_v_4_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NB-17-SQ59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.984296
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0254
GSE200673,GSE200691_1_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211262,GSE211263_3_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Leber congenital amaurosis 12	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.303
protein-cysteine S-palmitoyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.288
Acetolactate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.518
MRPL53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05833
Tibialis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.139
CRCGN015_MCF10A.TP53.M_24H:I07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.14295
Translation	Reactome Pathways 2024	1.0	null
ATG9A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04082
CRCGN015_MCF10A.TP53.M_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.01616
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27093
BRD-K20714346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00692
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.93064
CACNA1F	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00650002
BRD-K50721666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.58525
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.53199
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.818548
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.55679
BRD-K64135153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34588
GRK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49027
BRD-K68315360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64803
BRD-K67632894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16275
CRCGN009_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.74517
mitochondrial translation	GO Biological Process Annotations 2025	1.0	null
Noonan syndrome 3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.611
Ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.246
GSE200352_5_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_11_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CANX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00494158
BRD-K67740871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46098
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.604235
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mRNA cap methyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.53
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.23556
BRD-K86961579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62167
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205729,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.734641
CRCGN016_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.99252
mitochondrial inner membrane	GO Cellular Component Annotations 2023	1.0	null
GSE158834_10_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
PCDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20337
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.825
catalytic activity, acting on a tRNA	GO Molecular Function Annotations 2023	1.0	null
Pollen wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.671
CRCGN014_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7093
BRD-K55638368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04809
organelle inner membrane	GO Cellular Component Annotations 2023	1.0	null
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.988886
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.65577
BRD-K60192542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1416
decreased hematocrit	MGI Mouse Phenotype Associations 2023	1.0	null
Ovary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.757445
BRD-K63859730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0824
GSE102486,GSE102490_1_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Noc4p-Nop14p complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.414
FANCA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00628332
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:D21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13155
GSE123887,GSE123888_2_v_1_hpgd_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20005
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.59475
Superior temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.796
Exine	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.707
CRCGN012_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.30013
post-traumatic stress disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
CC-03-PW00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.719495
Serine C-palmitoyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.289
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K82909038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00688
MYCN-28898695-NB1643-HUMAN-NERVE-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Intussusception	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.807
ZNF211	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1851
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Asi complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.04
BRD-K14359942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0736
GATA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54697
TOMM20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54721
BRD-K59957885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3184
Clathrin adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.062
OB-17-DQ74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.338887
GSE147662_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5651844-41467_2017_1173_MOESM10_ESM.xlsx-ZZZ3_occupied_genes-Supplementary_Data_7_ZZZ3_occupied_genes_and_overlaps_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF-33576154-HUMAN-HILARLN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K95854766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49306
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9997
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.45637
Joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.88
CRCGN014_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18633
Chloroplast ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.393
7451_RPL24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.744401
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.95475
4017_MRPL58_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.712127
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_14_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322993
Alzheimer's disease or small vessel stroke	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.769897
XRCC2-RAD51D complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.66
Medial septum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.543
CRCGN009_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24052
CRCGN016_MCF10A.TP53.M_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.39496
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.07549
BRD-K85901675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30163
496100335_PCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02401
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.13005
PMC9859043-elife-78421-supp9.xlsx-LHX8_P-Gene_symbol_LHX8	Rummagene Transcription Factor Associations 2026	1.0	null
GSE224294_3_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8288
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
CKS1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00627361
GSE179880_10_v_3_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233183,GSE233187_3_v_6_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8384902-mmc5.xlsx-H2107_PROX1_ChIP-Symbol_PROX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K43295075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27557
CRCGN008_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0273
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
substance-related disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
BRD-K11554989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14189
Bt	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.699
BRD-A43409498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53528
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20285
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K61440521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.026
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.505693
BRD-A43076080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29869
a11	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.96
A549_WP1066_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122257
CRCGN009_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.173
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim29_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.99123
Phloem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.862
BRD-K30589514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11149
BRD-K99462197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17727
Set3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.411
CRCGN016_MCF10A.TP53.M_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.05103
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.12335
BRD-K05509844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4227
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.8613
FDPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57522
EID2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59376
BRD-K65005459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21585
AA-58-FJ71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.336571
DONSON	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04602
BRD-K67090705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06448
BRD-K66889220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78732
Columella	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.836
BRD-K60728944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00669
BRD-K20069402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20769
Fibula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.688
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2028
YY1-26981420-C2C12-MOUSE-MUSCLE	ChEA Transcription Factor Targets 2022	1.0	null
Mitochondrial translation elongation	Reactome Pathways 2024	1.0	null
GSE209582_1_v_0_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	1.22863
translation release factor activity, codon nonspecific	GO Molecular Function Annotations 2023	1.0	null
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K31747470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22901
BRD-K15975627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18337
CRCGN017_MCF10A.TP53.M_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.11522
GSE138945,GSE138947_0_v_1_mboat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.33
GSE138672_4_v_3_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GT1-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.756
8598_SUPT5H_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.525385
BRD-K89820077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28088
Mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Fc receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.255
COPI-coated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.131
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5419
GSE202434,GSE202438_15_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sexine	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.668
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pleural cavity	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.563
BC-82-PP66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302122
Talus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.482
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.471
Electroclinical syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
BRD-K73391462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05047
Autoimmune disease of musculoskeletal system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
Fruit peduncle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.692
HB611 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.886
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.503
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K81574470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09272
PMC12260418-pnas.2425984122.sd02.xlsx-TEAD1_6fraction_test_result-Unnamed_3_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K68980973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01188
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0464
CRCGN015_MCF10A_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36308
dg1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.302
GSE62843,GSE64370_0_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular organelle lumen	GO Cellular Component Annotations 2025	1.0	null
BRD-K83684822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18372
GSE178532_2_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K93488589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28964
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Endometrial glandular epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.512
Pericarp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.953
CRCGN015_MCF10A_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.14022
CCNA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00774158
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE144796_1_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.30258
PUF60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06737
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.47443
CRCGN015_HEPG2_48H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0415
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
AE-04-SN76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31588
BRD-K43798660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57608
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K05118964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42044
BB-41-XE67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.55187
Rarg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	59.821
mitochondrial matrix	GO Cellular Component Annotations 2023	1.0	null
BRD-K81318113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18671
Abductor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.655
DA-33-BM26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263328
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.29
7438_RPL14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51877
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.125
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.044
CRCGN008_HEPG2_24H:D14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13755
XAB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00963
FGFBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02753
HOXC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23327
BRD-K51253991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15341
BRD-K51322795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44083
CRCGN014_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8376
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Photosystem II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.794
OSRC2_KIDNEY	CCLE Cell Line Proteomics	1.0	3.67884
GSE181821_1_v_3_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AC-55-XA97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04516
BRD-K37866276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70799
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.95544
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K14868348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12932
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.6081
CD-96-HO43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206835
JC-02-ZR15_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.269193
GSE111247_14_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4004
Head capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.666
Presynaptic active zone cytoplasmic component	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.371
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.6006
CRCGN016_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50015
CRCGN017_MCF10A.WT.HP_24H:B16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6495
BRD-K61590534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14575
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
gl1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.089
Down syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.814
NVT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.844
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.3
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.66055
BRD-K14451397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18513
BRD-K94353570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02256
BE-27-RQ61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264078
Skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.006
Pericycle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.521
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.662216
GSE129287_0_v_1_cd200_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Erythroleukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.843